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Group I metabotropic glutamate receptors control proliferation, survival and differentiation of cultured neural progenitor cells isolated from the subventricular zone of adult mice (90 visite)

Castiglione M, Calafiore M, Costa L, Sortino MA, Nicoletti F, Copani A

Neuropharm (ISSN: 0028-3908, 1873-7064electronic, 0028-3908linking), 2008 Sep; 55(4): 560-567.

Tipo di articolo: Journal Article,

Impact factor: 3.383

Impact factor a 5 anni: 3.737


Parole chiave: Apoptosis, Differentiation, Metabotropic Glutamate Receptors, Neural Stem Cells, Proliferation, Subventricular Zone, 2 Methyl 6 (phenylethynyl)pyridine, 4 Carboxy 2 Methylphenylglycine, 6 Methyl 2 Phenylazo 3 Pyridinol, 7 (hydroxyimino)cyclopropa[b]chromen 1a Carboxylate Ethyl Ester, Ester Derivative, Metabotropic Receptor 1, Quisqualic Acid, Unclassified Drug, Animal Cell, Article, Brain Region, Cell Culture, Cell Cycle, Cell Differentiation, Cell Lineage, Cell Proliferation, Cell Survival, Controlled Study, Drug Activity, Gene Expression, Mouse, Nonhuman, Priority Journal, Protein Expression, Adult Stem Cells, Cell Count, Dose-Response Relationship, Excitatory Amino Acid Agonists, Excitatory Amino Acid Antagonists, Flow Cytometry, Lateral Ventricles, Nerve Tissue Proteins, Neural Cell Adhesion Molecule L1, Neurons, Sialic Acids, 2 Methyl 6 (phenylethynyl) Pyridine, 7 (hydroxyimino) Cyclopropa [b] Chromen 1a Carboxylate Ethyl Ester,

Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-49949100934&partnerID=40&md5=0c7b14bf8baf40bb10d8ce652795fcca

Neural progenitor cells (NPCs) are found in the subventricular zone (SVZ) of the adult brain, a specialized neurogenic niche that might provide a substrate for brain repair after injury. The incomplete knowledge of how NPCs in the niche respond to local signals limits the use of cultured NPCs in the development of cell transplantation strategies. We show that neurospheres obtained from the SVZ of the adult mouse expressed functional mGlu1 and mGlu5 metabotropic glutamate receptors. Pharmacological blockade of mGlu5 receptors promoted the apoptotic death of progenitors undergoing differentiation into neurons (PSA/NCAM+ cells for the most part), whereas blockade of mGlu1 receptors reduced the proliferation rate of NPCs, and promoted their differentiation towards the neuronal lineage. We conclude that endogenous activation of mGlu5 receptors might support specifically the survival of neuronal-restricted precursors, whereas endogenous activation of mGlu1 receptors might sustain the proliferation of earlier progenitors. Moreover, mGlu1 receptor antagonists increased the survival of NPCs, suggesting that endogenously activated mGlu1 receptors might play a role in the natural cell loss regulating the number or the type of progenitors. © 2008 Elsevier Ltd. All rights reserved.
*** IBB - CNR ***

Department of Pharmaceutical Sciences, University of Catania, Catania, Italy

Department of Physiological Sciences, University of Catania, Catania, Italy

Department of Experimental and Clinical Pharmacology, University of Catania, Catania, Italy

Department of Human Physiology and Pharmacology, University of Rome La Sapienza, Rome, Italy

I.N.M. Neuromed, Pozzilli, Italy

I.B.B., CNR-Catania, Catania, Italy

I. N. M. Neuromed, Pozzilli, Italy

I. B. B., CNR-Catania, Catania, Italy
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Brazel, C. Y., Nunez, J. L., Yang, Z., Levison, S. W., Glutamate enhances survival and proliferation of neural progenitors derived from the subventricular zone (2005) Neuroscience, 131, pp. 55-65

Cameron, H. A., McEwen, B. S., Gould, E., Regulation of adult neurogenesis by excitatory input and NMDA receptor activation in the dentate gyrus (1995) J. Neurosci., 15, pp. 4687-4692

Canudas, A. M., Di Giorgi-Gerevini, V., Iacovelli, L., Nano, G., D'Onofrio, M., Arcella, A., Giangaspero, F., Melchiorri, D., PHCCC, a specific enhancer of type 4 metabotropic glutamate receptors, reduces proliferation and promotes differentiation of cerebellar granule cell neuroprecursors (2004) J. Neurosci., 24, pp. 10343-10352

Catania, M. V., Bellomo, M., Di Giorgi-Gerevini, V., Seminara, G., Giuffrida, R., Romeo, R., De Blasi, A., Nicoletti, F., Endogenous activation of group-I metabotropic glutamate receptors is required for differentiation and survival of cerebellar Purkinje cells (2001) J. Neurosci., 21, pp. 7664-7673

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Gage, F. H., Mammalian neural stem cells (2000) Science, 287, pp. 1433-1438

Ge, S., Pradhan, D. A., Ming, G. -L., Song, H., GABA sets the tempo for activity-dependent adult neurogenesis (2007) Trends Neurosci., 30, pp. 1-8

Hampson, D. R., Theriault, E., Huang, X. P., Kristensen, P., Pickering, D. S., Franck, J. E., Mulvihill, E. R., Characterization of two alternatively spliced forms of a metabotropic glutamate receptor in the central nervous system of the rat (1994) Neuroscience, 60, pp. 325-336

Haydar, T. F., Wang, F., Schwartz, M. L., Rakic, P., Differential modulation of proliferation in the neocortical ventricular and subventricular zones (2000) J. Neurosci., 20, pp. 5764-5774

Kornack, D. R., Rakic, P., Continuation of neurogenesis in the hippocampus of the adult macaque monkey (1999) Proc. Natl. Acad. Sci. U. S. A., 96, pp. 5768-5773

LoTurco, J. J., Owens, D. F., Heath, M. J., Davis, M. B., Kriegstein, A. R., GABA and glutamate depolarize cortical progenitor cells and inhibit DNA synthesis (1995) Neuron, 15, pp. 1287-1298

Rao, V. R., Finkbeiner, S., NMDA and AMPA receptors: old channels, new tricks (2007) Trends Neurosci., 30, pp. 284-291

Ribak, C. E., Dashtipour, K., Neuroplasticity in the damaged dentate gyrus of the epileptic brain (2002) Prog. Brain Res., 136, pp. 319-328

Sharp, F. R., Liu, J., Bernabeu, R., Neurogenesis following brain ischemia (2002) Brain Res. Dev. Brain Res., 134, pp. 23-30

Varney, M. A., Cosford, N. D., Jachec, C., Rao, S. P., Sacaan, A., Lin, F. F., Bleicher, L., Johnson, E. C., SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5 (1999) J. Pharmacol. Exp. Ther., 290, pp. 170-181

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* Cellular and molecular effects of protons: Apoptosis induction and potential implications for cancer therapy (113 visite)
Apoptosis (ISSN: 1360-8185), 2006 Jan; 11(1): 57-66.
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Cozzolino R, Palladino P, Rossi F, Cali G, Benedetti E, Laccetti P
* Antineoplastic cyclic astin analogues kill tumour cells via caspase-mediated induction of apoptosis (157 visite)
Carcinogenesis (ISSN: 0143-3334), 2005 Apr; 26(4): 733-739.
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Del Vecchio S, Zannetti A, Salvatore B, Paone G, Fonti R, Iommelli F, De Renzo A, Rotoli B, Salvatore M
* 99mTc-MIBI uptake in Bcl-2 overexpressing non-Hodgkin's lymphoma patients during drug-induced apoptosis (90 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2004 Sep; 31: N/D-N/D.
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Penolazzi L, Borgatti M, Lambertini E, Mischiati C, Finotti A, Romanelli A, Saviano M, Pedone C, Piva R, Gambari R
* Peptide nucleic acid-DNA decoy chimeras targeting NF-kappa B transcription factors: Induction of apoptosis in human primary osteoclasts (109 visite)
International Journal Of Molecular Medicine (ISSN: 1107-3756), 2004 Sep; 14(2): 145-152.
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Spalletti-cernia D, Sorrentino R, Di Gaetano S, Arciello A, Garbi C, Piccoli R, D'Alessio G, Vecchio G, Laccetti P, Santoro M
* Antineoplastic ribonucleases selectively kill thyroid carcinoma cells via caspase-mediated induction of apoptosis (111 visite)
Journal Of Clinical Endocrinology & Metabolism (ISSN: 0021-972x), 2003 Jun; 88(6): 2900-2907.
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Russo M, Palumbo R, Mupo A, Tosto M, Iacomino G, Scognamiglio A, Tedesco I, Galano G, Russo GL
* Flavonoid quercetin sensitizes a CD95-resistant cell line to apoptosis by activating protein kinase Cα (135 visite)
Oncogene (ISSN: 0950-9232, 1476-5594), 2003; 22(21): 3330-3342.
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Aloj L, Zannetti A, Caraco C, Fonti R, Del Vecchio S, Salvatore M
* 99mTc-MIBI uptake in breast cancer cells during early phases of apoptosis induction with Staurosporine (89 visite)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2001 Sep; 28(8): N/D-N/D.
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Del Vecchio S, Ciarmiello A, Zannetti A, Fonti R, Botti G, D'Aiuto G, Salvatore M
Efflux rate of Tc-99m-MIBI and apoptosis in untreated breast cancer patients (94 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2000 May; 41(5): N/D-N/D.
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Russo M, Palumbo R, Tedesco I, Mazzarella G, Russo P, Iacomino G, Russo GL
Quercetin and anti-CD95(Fas/Apo1) enhance apoptosis in HPB-ALL cell line (90 visite)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 1999 Dec 3; 462(3): 322-328.
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Aloj L, Del Vecchio S, Damiano M, Zannetti A, Di Gennaro F, Imbriaco M, Salvatore M
Fractional retention of 99mTc-MIBI and proliferation in untreated breast cancer (86 visite)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1999 Sep; 26(9): N/D-N/D.
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Correale P, Caraglia M, Pepe S, Ricciardi B, Barile C, Montagnani S, Pacelli R, Bianco A, Tagliaferri P
PHORBOL 12-MYRISTATE 13-ACETATE (PMA) INDUCES NEUROENDOCRINE-LIKE DIFFERENTIATION AND REVERSES DOXORUBICIN-RESISTANCE OF HUMAN COLON-CARCINOMA CELLS IN-VITRO (67 visite)
Int J Oncol (ISSN: 1019-6439, 1791-2423electronic, 1019-6439linking), 1994 Feb; 4(2): 423-427.
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Fonti R, Latella G, Bises G, Magliocca F, Nobili F, Caprilli R, Sambuy Y
Human colonocytes in primary culture: a model to study epithelial growth, metabolism and differentiation (100 visite)
International Journal Of Colorectal Disease (ISSN: 0179-1958, 0179-1958linking), 1994; 9(1): 13-22.
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29 Records (22 escludendo Abstract e Conferenze).
Impact factor totale: 110.71 (80.735 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 113.317 (78.016 escludendo Abstract e Conferenze).







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