How the binding and degrading capabilities of insulin degrading enzyme are affected by ubiquitin (252 views visite)
Bba-Gen Subjects (ISSN: 0006-3002, 1570-9639, 0925-4439), 2008 Jul; 1784(7-8): 1122-1126.
Paper type Tipo di articolo: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 2.233, 5-year impact factor Impact factor a 5 anni: 2.816
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-52449135535&partnerID=40&md5=2482a9385c0ad8bc529b77268e3a5fb7
Keywords Parole chiave: Insulin Degrading Enzyme, Mass Spectrometry, Noncovalent Interaction, Surface Plasmon Resonance, Ubiquitin, Insulinase, Article, Enzyme Activity, Enzyme Binding, Enzyme Degradation, Priority Journal, Protein Degradation, Protein Function, Animals, Insulysin, Protein Binding, Recombinant Proteins, Matrix-Assisted Laser Desorption-Ionization, Spodoptera,
Affiliations Affiliazioni:
*** IBB - CNR ***
Chemistry Department, Universita di Catania, Viale Andrea Doria 6, 95125, Catania, Italy.
Istituto Biostrutture e Bioimmagini, CNR, Viale A. Doria 6, Catania, Italy
References Riferimenti:
Farris, W., Mansourian, S., Chang, Y., Lindsley, L., Eckman, E.A., Frosch, M.P., Eckman, C.B., Guenette, S., Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo (2003) Proc. Natl. Acad. Sci. U. S. A., 100, pp. 4162-416
Shen, Y., Joachimiak, A., Rosner, M.R., Tang, W.-J., Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism (2006) Nature, 443, pp. 870-874
Soto, C., Unfolding the role of protein misfolding in neurodegenerative diseases (2003) Nat. Rev. Neurosci., 4, pp. 49-60
Chiti, F., Dobson, C.M., Protein misfolding, functional amyloid, and human disease (2006) Annu. Rev. Biochem., 75, pp. 333-366
Bertram, L., Blacker, D., Mullin, K., Keeney, D., Jones, J., Basu, S., Yhu, S., Tanzi, R.E., Evidence for genetic linkage of Alzheimer's disease to chromosome 10q (2000) Science, 290, pp. 2302-2303
Qiu, W.Q., Folstein, M.F., Insulin, insulin-degrading enzyme and amyloid-b peptide in Alzheimer's disease: review and hypothesis (2006) Neurobiol. aging, 27, pp. 190-198
Bennett, R.G., Hamel, F.G., Duckworth, W.C., Characterization of the insulin inhibition of the peptidolytic activities of the insulin-degrading enzyme-proteasome complex (1997) Diabetes, 46, pp. 197-203
Saric, T., Muller, D., Seitz, H.-J., Pavelic, K., Non-covalent interaction of ubiquitin with insulin-degrading enzyme (2003) Mol. Cell. Endocrinol., 204, pp. 11-20
Duckworth, W.C., Bennett, R.G., Hamel, F.G., Insulin acts intracellularly on proteasomes through insulin-degrading enzyme (1998) Biochem. Biophys. Res. Commun., 244, pp. 390-394
Bennett, E.J., Shaler, T.A., Woodman, B., Ryu, K.-Y., Zaitseva, T.S., Becker, C.H., Bates, G.P., Kopito, R.R., Global changes to the ubiquitin system in Huntington's disease (2007) Nature, 448, pp. 704-709
Ross, C.A., Pickart, C.M., The ubiquitin-proteasome pathway in Parkinson's disease and other neurodegenerative diseases (2004) Trends Cell Biol., 14, pp. 703-711
Lam, Y.A., Pickart, C.M., Alban, A., Landon, M., Jamieson, C., Ramage, R., Mayer, R.J., Layfield, R., Inhibition of the ubiquitin-proteasome system in Alzheimer's disease (2000) Proc. Natl. Acad. Sci. U. S. A., 97, pp. 9902-9906
Grasso, G., Rizzarelli, E., Spoto, G., AP/MALDI-MS complete characterization of insulin fragments produced by the interaction of IDE with bovine insulin (2007) J. Mass Spectrom., 42, pp. 1590-1598
Grasso, G., D'Agata, R., Rizzarelli, E., Spoto, G., D'Andrea, L., Pedone, C., Picardi, A., Yeo, K.J., Activity of anchored human matrix metalloproteinase-1 catalytic domain on Au (111) surfaces monitored by ESI-MS (2005) J. Mass Spectrom., 40, pp. 1565-1571
Shevchenko, A., Shevchenko, A., Evaluation of the efficiency of in-gel digestion of proteins by peptide isotopic labeling and MALDI mass spectrometry (2001) Anal. Biochem., 296, pp. 279-283
Hershko, A., Ciechanover, A., The ubiquitin system (1998) Annu. Rev. Biochem., 67, pp. 425-479
Qiu, W. Q., Folstein, M. F., Insulin, insulin-degrading enzyme and amyloid-b peptide in Alzheimer's disease: review and hypothesis (2006) Neurobiol. aging, 27, pp. 190-198
Bennett, R. G., Hamel, F. G., Duckworth, W. C., Characterization of the insulin inhibition of the peptidolytic activities of the insulin-degrading enzyme-proteasome complex (1997) Diabetes, 46, pp. 197-203
Duckworth, W. C., Bennett, R. G., Hamel, F. G., Insulin acts intracellularly on proteasomes through insulin-degrading enzyme (1998) Biochem. Biophys. Res. Commun., 244, pp. 390-394
Bennett, E. J., Shaler, T. A., Woodman, B., Ryu, K. -Y., Zaitseva, T. S., Becker, C. H., Bates, G. P., Kopito, R. R., Global changes to the ubiquitin system in Huntington's disease (2007) Nature, 448, pp. 704-709
Ross, C. A., Pickart, C. M., The ubiquitin-proteasome pathway in Parkinson's disease and other neurodegenerative diseases (2004) Trends Cell Biol., 14, pp. 703-711
Lam, Y. A., Pickart, C. M., Alban, A., Landon, M., Jamieson, C., Ramage, R., Mayer, R. J., Layfield, R., Inhibition of the ubiquitin-proteasome system in Alzheimer's disease (2000) Proc. Natl. Acad. Sci. U. S. A., 97, pp. 9902-9906
Bba-Gen Subjects (ISSN: 0006-3002, 1570-9639, 0925-4439), 2008 Jul; 1784(7-8): 1122-1126.
Paper type Tipo di articolo: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 2.233, 5-year impact factor Impact factor a 5 anni: 2.816
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-52449135535&partnerID=40&md5=2482a9385c0ad8bc529b77268e3a5fb7
Keywords Parole chiave: Insulin Degrading Enzyme, Mass Spectrometry, Noncovalent Interaction, Surface Plasmon Resonance, Ubiquitin, Insulinase, Article, Enzyme Activity, Enzyme Binding, Enzyme Degradation, Priority Journal, Protein Degradation, Protein Function, Animals, Insulysin, Protein Binding, Recombinant Proteins, Matrix-Assisted Laser Desorption-Ionization, Spodoptera,
Affiliations Affiliazioni:
*** IBB - CNR ***
Chemistry Department, Universita di Catania, Viale Andrea Doria 6, 95125, Catania, Italy.
Istituto Biostrutture e Bioimmagini, CNR, Viale A. Doria 6, Catania, Italy
References Riferimenti:
Farris, W., Mansourian, S., Chang, Y., Lindsley, L., Eckman, E.A., Frosch, M.P., Eckman, C.B., Guenette, S., Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo (2003) Proc. Natl. Acad. Sci. U. S. A., 100, pp. 4162-416
Shen, Y., Joachimiak, A., Rosner, M.R., Tang, W.-J., Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism (2006) Nature, 443, pp. 870-874
Soto, C., Unfolding the role of protein misfolding in neurodegenerative diseases (2003) Nat. Rev. Neurosci., 4, pp. 49-60
Chiti, F., Dobson, C.M., Protein misfolding, functional amyloid, and human disease (2006) Annu. Rev. Biochem., 75, pp. 333-366
Bertram, L., Blacker, D., Mullin, K., Keeney, D., Jones, J., Basu, S., Yhu, S., Tanzi, R.E., Evidence for genetic linkage of Alzheimer's disease to chromosome 10q (2000) Science, 290, pp. 2302-2303
Qiu, W.Q., Folstein, M.F., Insulin, insulin-degrading enzyme and amyloid-b peptide in Alzheimer's disease: review and hypothesis (2006) Neurobiol. aging, 27, pp. 190-198
Bennett, R.G., Hamel, F.G., Duckworth, W.C., Characterization of the insulin inhibition of the peptidolytic activities of the insulin-degrading enzyme-proteasome complex (1997) Diabetes, 46, pp. 197-203
Saric, T., Muller, D., Seitz, H.-J., Pavelic, K., Non-covalent interaction of ubiquitin with insulin-degrading enzyme (2003) Mol. Cell. Endocrinol., 204, pp. 11-20
Duckworth, W.C., Bennett, R.G., Hamel, F.G., Insulin acts intracellularly on proteasomes through insulin-degrading enzyme (1998) Biochem. Biophys. Res. Commun., 244, pp. 390-394
Bennett, E.J., Shaler, T.A., Woodman, B., Ryu, K.-Y., Zaitseva, T.S., Becker, C.H., Bates, G.P., Kopito, R.R., Global changes to the ubiquitin system in Huntington's disease (2007) Nature, 448, pp. 704-709
Ross, C.A., Pickart, C.M., The ubiquitin-proteasome pathway in Parkinson's disease and other neurodegenerative diseases (2004) Trends Cell Biol., 14, pp. 703-711
Lam, Y.A., Pickart, C.M., Alban, A., Landon, M., Jamieson, C., Ramage, R., Mayer, R.J., Layfield, R., Inhibition of the ubiquitin-proteasome system in Alzheimer's disease (2000) Proc. Natl. Acad. Sci. U. S. A., 97, pp. 9902-9906
Grasso, G., Rizzarelli, E., Spoto, G., AP/MALDI-MS complete characterization of insulin fragments produced by the interaction of IDE with bovine insulin (2007) J. Mass Spectrom., 42, pp. 1590-1598
Grasso, G., D'Agata, R., Rizzarelli, E., Spoto, G., D'Andrea, L., Pedone, C., Picardi, A., Yeo, K.J., Activity of anchored human matrix metalloproteinase-1 catalytic domain on Au (111) surfaces monitored by ESI-MS (2005) J. Mass Spectrom., 40, pp. 1565-1571
Shevchenko, A., Shevchenko, A., Evaluation of the efficiency of in-gel digestion of proteins by peptide isotopic labeling and MALDI mass spectrometry (2001) Anal. Biochem., 296, pp. 279-283
Hershko, A., Ciechanover, A., The ubiquitin system (1998) Annu. Rev. Biochem., 67, pp. 425-479
Qiu, W. Q., Folstein, M. F., Insulin, insulin-degrading enzyme and amyloid-b peptide in Alzheimer's disease: review and hypothesis (2006) Neurobiol. aging, 27, pp. 190-198
Bennett, R. G., Hamel, F. G., Duckworth, W. C., Characterization of the insulin inhibition of the peptidolytic activities of the insulin-degrading enzyme-proteasome complex (1997) Diabetes, 46, pp. 197-203
Duckworth, W. C., Bennett, R. G., Hamel, F. G., Insulin acts intracellularly on proteasomes through insulin-degrading enzyme (1998) Biochem. Biophys. Res. Commun., 244, pp. 390-394
Bennett, E. J., Shaler, T. A., Woodman, B., Ryu, K. -Y., Zaitseva, T. S., Becker, C. H., Bates, G. P., Kopito, R. R., Global changes to the ubiquitin system in Huntington's disease (2007) Nature, 448, pp. 704-709
Ross, C. A., Pickart, C. M., The ubiquitin-proteasome pathway in Parkinson's disease and other neurodegenerative diseases (2004) Trends Cell Biol., 14, pp. 703-711
Lam, Y. A., Pickart, C. M., Alban, A., Landon, M., Jamieson, C., Ramage, R., Mayer, R. J., Layfield, R., Inhibition of the ubiquitin-proteasome system in Alzheimer's disease (2000) Proc. Natl. Acad. Sci. U. S. A., 97, pp. 9902-9906
Insulin degrading enzyme (IDE) is known to play a pivotal role on amyloidogenic peptide degradation but little is known about the changes in the proteolytic activity of the enzyme upon modification of external factors. Particularly, although it has been reported that altered ubiquitin concentration and/or hyperinsulinaemia increase the risk of developing Alzheimer's disease (AD), the molecular mechanism involved is unclear. In this work, we study the role that ubiquitin plays on IDE capability of binding and degrading insulin molecules and the obtained results indicate that ubiquitin has an allosteric role for IDE and high ubiquitin levels impair IDE activity.
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* Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation (401 visite)
Nature Cell Biol Nature Cell Biology (ISSN: 1476-4679, 1465-7392), 2010 Feb; 12(2): 132-142.
Impact Factor: 19.407
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Galasso G, De Rosa R, Piscione F, Iaccarino G, Vosa C, Sorriento D, Piccolo R, Rapacciuolo A, Walsh K, Chiariello M
* Myocardial expression of FOXO3a-Atrogin-1 pathway in human heart failure (178 visite)
Eur J Heart Fail European Journal Of Heart Failure (ISSN: 1388-9842), 2010; 12(12): 1290-1296.
Impact Factor: 4.512
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Arnesano F, Scintilla S, Calò V, Bonfrate E, Ingrosso C, Losacco M, Pellegrino T, Rizzarelli E, Natile G
* Copper-triggered aggregation of ubiquitin (445 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2009 Sep 16; 4(9): e7052-e7052.
Impact Factor: 4.351
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Farina AR, Tacconelli A, Cappabianca L, Cea G, Panella S, Chioda A, Romanelli A, Pedone C, Gulino A, Mackay AR
* The alternative TrkAIII splice variant targets the centrosome and promotes genetic instability (278 visite)
Mol Cell Biol (ISSN: 1098-5549, 0270-7306), 2009 Sep 1; 29(17): 4812-4830.
Impact Factor: 6.057
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Grasso G, Rizzarelli E, Spoto G
* The proteolytic activity of insulin-degrading enzyme: a mass spectrometry study (309 visite)
J Mass Spectrom (ISSN: 1096-9888, 1076-5174), 2009 May; 44(5): 735-741.
Impact Factor: 3.411
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Grasso G, Bush AI, D'Agata R, Rizzarelli E, Spoto G
* Enzyme solid-state support assays: a surface plasmon resonance and mass spectrometry coupled study of immobilized insulin degrading enzyme (240 visite)
Eur Biophys J (ISSN: 1432-1017, 0175-7571), 2009 Apr; 38(4): 407-414.
Impact Factor: 2.437
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Ciaccio C, Tundo GR, Grasso G, Spoto G, Marasco D, Ruvo M, Gioia M, Rizzarelli E, Coletta M
* Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity (354 visite)
J Mol Biol (ISSN: 1089-8638, 0022-2836, 1089-8638electronic), 2009 Feb 6; 385(5): 1556-1567.
Impact Factor: 3.871
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Hilvo M, Baranauskiene L, Salzano AM, Scaloni A, Matulis D, Innocenti A, Scozzafava A, Monti SM, Di Fiore A, De Simone G, Lindfors M, Janis J, Valjakka J, Pastorekova S, Pastorek J, Kulomaa MS, Nordlund HR, Supuran CT, Parkkila S
* Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes (327 visite)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Oct 10; 283(41): 27799-27809.
Impact Factor: 5.52
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Viparelli F, Cassese A, Doti N, Paturzo F, Marasco D, Dathan NA, Monti SM, Basile G, Ungaro P, Sabatella M, Miele C, Teperino R, Consiglio E, Pedone C, Beguinot F, Formisano P, Ruvo M
* Targeting of PED/PEA-15 molecular interaction with phospholipase D1 enhances insulin sensitivity in skeletal muscle cells (325 visite)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Sep 1; 283(31): 21769-21778.
Impact Factor: 5.52
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Grasso G, Rizzarelli E, Spoto G
* AP/MALDI-MS complete characterization of the proteolytic fragments produced by the interaction of insulin degrading enzyme with bovine insulin (356 visite)
J Mass Spectrom (ISSN: 1076-5174, 1096-9888), 2007 Dec; 42(12): 1590-1598.
Impact Factor: 3.062
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Ragno R, Simeoni S, Castellano S, Vicidomini C, Mai A, Caroli A, Tramontano A, Bonaccini C, Trojer P, Bauer I, Brosch G, Sbardella G
* Small molecule inhibitors of histone arginine methyltransferases: Homology modeling, molecular docking, binding mode analysis, and biological evaluations (324 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2007 Mar 22; 50(6): 1241-1253.
Impact Factor: 4.895
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Di Fiore A, Scozzafava A, Winum JY, Montero JL, Pedone C, Supuran CT, De Simone G
* Carbonic anhydrase inhibitors: binding of an antiglaucoma glycosyl-sulfanilamide derivative to human isoform II and its consequences for the drug design of enzyme inhibitors incorporating sugar moieties (316 visite)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2007 Mar 15; 17(6): 1726-1731.
Impact Factor: 2.604
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Pellecchia MT, Varrone A, Annesi G, Amboni M, Cicarelli G, Sansone V, Annesi F, Rocca FE, Vitale C, Pappata S, Quattrone A, Barone P
* Parkinsonism and essential tremor in a family with pseudo-dominant inheritance of PARK2: An FP-CIT SPECT study (214 visite)
Mov Disord (ISSN: 0885-3185, 1531-8257), 2007 Mar 15; 22(4): 559-563.
Impact Factor: 3.207
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Milardi D, Arnesano F, Grasso G, Magrì A, Tabbì G, Scintilla S, Natile G, Rizzarelli E
* Ubiquitin stability and the Lys63-linked polyubiquitination site are compromised on copper binding (211 visite)
Angew Chem Int Ed (ISSN: 1433-7851, 1521-3773electronic), 2007; 46(42): 7993-7995.
Impact Factor: 10.031
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Sciacca MFM, Milardi D, Pappalardo M, La Rosa C, Grasso DM
* Role of electrostatics in the thermal stability of ubiquitin: A combined DSC and MM study (176 visite)
Journal Of Thermal Analysis And Calorimetry (ISSN: 1388-6150), 2006 Nov; 86(2): 311-314.
Impact Factor: 1.438
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Santelli E, Leone M, Li C, Fukushima T, Preece NE, Olson AJ, Ely KR, Reed JC, Pellecchia M, Liddington RC, Matsuzawa S-I
* Structural analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex (289 visite)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2005 Oct 7; 280(40): 34278-34287.
Impact Factor: 5.854
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Varrone A, Pellecchia MT, Amboni M, Sansone V, Salvatore E, Ghezzi D, Garavaglia B, Brice A, Brunetti A, Bonavita V, De Michele G, Salvatore M, Pappata S, Barone P
* Imaging of dopaminergic dysfunction with [123I]FP-CIT SPECT in early-onset parkin disease (3832 visite)
Neurology (ISSN: 0028-3878, 1526-632x, 1526-632xelectronic), 2004 Dec 14; 63(11): 2097-2103.
Impact Factor: 5.973
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De Simone G, Menchise V, Alterio V, Mandrich L, Rossi M, Manco G, Pedone C
* The crystal structure of an EST2 mutant unveils structural insights on the H group of the carboxylesterase/lipase family (311 visite)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2004 Oct 8; 343(1): 137-146.
Impact Factor: 5.542
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Ohlenschlager O, Wohnert J, Bucci E, Seitz S, Hafner S, Ramachandran R, Zell R, Gorlach M
* The Structure of the Stemloop D Subdomain of Coxsackievirus B3 Cloverleaf RNA and Its Interaction with the Proteinase 3C (351 visite)
Structure (ISSN: 0969-2126, 1878-4186), 2004; 12(2): 237-248.
Impact Factor: 5.185
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Esposito L, Bruno I, Sica F, Raia CA, Giordano A, Rossi M, Mazzarella L, Zagari A
* Crystal structure of a ternary complex of the alcohol dehydrogenase from Sulfolobus solfataricus (270 visite)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2003 Dec 16; 42(49): 14397-14407.
Impact Factor: 3.922
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Esposito L, Bruno I, Sica F, Raia CA, Giordano A, Rossi M, Mazzarella L, Zagari A
* Structural study of a single-point mutant of Sulfolobus solfataricus alcohol dehydrogenase with enhanced activity (234 visite)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2003 Mar 27; 539(1-3): 14-18.
Impact Factor: 3.609
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Esposito L, Sica F, Raia CA, Giordano A, Rossi M, Mazzarella L, Zagari A
* Crystal Structure Of The Alcohol Dehydrogenase From The Hyperthermophilic Archaeon Sulfolobus Solfataricus At 1. 85 Angstrom Resolution (293 visite)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2002 Apr 26; 318(2): 463-477.
Impact Factor: 5.359
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Vitagliano L, Merlino A, Zagari A, Mazzarella L
* Reversible substrate-induced domain motions in ribonuclease (211 visite)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2002 Jan 1; 46(1): 97-104.
Impact Factor: 4.096
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Vitagliano L, Merlino A, Zagari A, Mazzarella L
Productive and nonproductive binding to ribonuclease A: X-ray structure of two complexes with uridylyl(2 ', 5 ')guanosine (277 visite)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 2000 Jun; 9(6): 1217-1225.
Impact Factor: 3.869
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Vitagliano L, Adinolfi S, Sica F, Merlino A, Zagari A, Mazzarella L
A potential allosteric subsite generated by domain swapping in bovine seminal ribonuclease (232 visite)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 1999 Oct 29; 293(3): 569-577.
Impact Factor: 5.501
Dettagli Esporta in BibTeX Esporta in EndNote
Vitagliano L, Adinolfi S, Riccio A, Sica F, Zagari A, Mazzarella L
Binding of a substrate analog to a domain swapping protein: X-ray structure of the complex of bovine seminal ribonuclease with uridylyl(2 ', 5 ')adenosine (260 visite)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 1998 Sep; 7(8): 1691-1699.
Impact Factor: 4.44
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58 Records (56 escludendo Abstract e Conferenze).
Impact factor totale: 312.315 (304.73 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 309.681 (301.596 escludendo Abstract e Conferenze).
Impact factor totale: 312.315 (304.73 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 309.681 (301.596 escludendo Abstract e Conferenze).
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