In vivo and in vitro characterization of CCK8 bearing a histidine-based chelator labeled with Tc-99m-tricarbonyl(340 views visite) D'Andrea LD, Testa I, Panico M, Di Stasi R, Carac C, Tarallo L, Arra C, Barbieri A, Romanelli A, Aloj L
Istituto di Biostrutture e Bioimmagini, CNR, 80134 Napoli, Italy Area Funzionale di Medicina Nucleare, Istituto Nazionale Tumori, Fondazione G. Pascale, Via M. Semmola, 80131 Napoli, Italy UOS Sperimentazione Animale, Istituto Nazionale Tumori, Fondazione G. Pascale, 80131 Napoli, Italy Dipartimento delle Scienze Biologiche, Università di Napoli Federico II, 80134 Napoli, Italy
Laverman, P., Roosenburg, S., Gotthardt, M., Park, J., Oven, W.J., de Jong, M., Hellmich, M.R., Boerman, O.C., (2008) Eur J Nucl Med Mol Imaging, 35, pp. 386-392
Melis, M., Krenning, E.P., Bernard, B.F., de Visser, M., Rolleman, E., de Jong, M., (2007) Nucl Med Biol, 34, pp. 633-641
Agostini, S., Bolzati, C., Didone, E., Cavazza-Ceccato, M., Refosco, F., Aloj, L., Arra, C., Morelli, G., (2007) J Pept Sci, 13, pp. 211-219
Laverman, P., Behe, M., Oyen, W.J., Willems, P.H., Corstens, F.H., Behr, T.M., Boerman, O.C., (2004) Bioconjug Chem, 15, pp. 561-568
Alberto, R., Schibli, R., Egli, A., Schubiger, P.A., Abram, U., Kaden, T.A., (1998) J Am Chem Soc, 120, pp. 7987-7988
Waibel, R., Alberto, R., Willuda, J., Finnern, R., Schibli, R., Stichelberger, A., Egli, A., Schubiger, P.A., (1999) Nat Biotechnol, 17, pp. 897-901
Metzler-Nolte, N., (2001) Angew Chem Int Ed Engl, 40, pp. 1040-1043
Alberto, R., Pak, J.K., van Staveren, D., Mundwiler, S., Benny, P., (2004) Biopolymers, 76, pp. 324-333
von Guggenberg, E., Behe, M., Behr, T.M., Saurer, M., Seppi, T., Decristoforo, C., (2004) Bioconjug Chem, 15, pp. 864-871
Zhang, K., An, R., Gao, Z., Zhang, Y., Aruva, M.R., (2006) Nucl Med Biol, 33, pp. 505-512
Maes, V., Garcia-Garayoa, E., Blauenstein, P., Tourwe, D., (2006) J Med Chem, 49, pp. 1833-1836
Egli, A., Alberto, R., Tannahill, L., Schibli, R., Abram, U., Schaffland, A., Waibel, R., Schubiger, P.A., (1999) J Nucl Med, 40, pp. 1913-1917
La Bella, R., Garcia-Garayoa, E., Langer, M., Blauenstein, P., Beck-Sickinger, A.G., Schubiger, P.A., (2002) Nucl Med Biol, 29, pp. 553-560
Bullok, K.E., Dyszlewski, M., Prior, J.L., Pica, C.M., Sharma, V., Piwnica-Worms, D., (2002) Bioconjug Chem, 13, pp. 1226-1237
Di Blasio, B., Pavone, V., Lombardi, A., Pedone, C., Benedetti, E., (1993) Biopolymers, 33, pp. 1037-1049
Eckelman, W.C., (1994) Nucl Med Biol, 21, pp. 759-769
Wank, S. A., (1998) Am J Physiol, 274, pp. G607-G613
Reubi, J. C., Schaer, J. C., Waser, B., (1997) Cancer Res, 57, pp. 1377-1386
Reubi, J. C., Waser, B., Schaer, J. C., Laederach, U., Erion, J., Srinivasan, A., Schmidt, M. A., Bugaj, J. E., (1998) Eur J Nucl Med, 25, pp. 481-490
Bullok, K. E., Dyszlewski, M., Prior, J. L., Pica, C. M., Sharma, V., Piwnica-Worms, D., (2002) Bioconjug Chem, 13, pp. 1226-1237
Eckelman, W. C., (1994) Nucl Med Biol, 21, pp. 759-769
In vivo and in vitro characterization of CCK8 bearing a histidine-based chelator labeled with Tc-99m-tricarbonyl
The development of receptor targeting radiolabeled ligands has gained much interest in recent years for diagnostic and therapeutic applications in nuclear medicine. Cholecystokinin (CCK) receptors have been shown to be overexpressed in a subset of neuroendocrine and other tumors. We are evaluating binding and biodistribution properties of a CCK8 peptide derivative labeled with Tc-99m(I)-tricarbonyl. The CCK8 peptide was modified at its N-terminus by adding to its N-terminus two lysine-histidine modules (KH), where histidine is coupled to the side chain of the lysine ((KH)(2)-CCK8). Tc-99m(I)-tricarbonyl was generated with the IsoLink (TM) kit. A431 cells stably transfected with a cDNA encoding for the human CCK2 receptor were utilized to determine binding affinity, internalization, and retention of the labeled peptide, in comparison with wild-type A431 cells. A nude mouse tumor model was obtained by generating A431-CCK2R and A431-control tumors in opposite flanks of the animals. High specific activity labeling with 99(m)Tc was achieved. In A431-CCK2R cells, specific saturable binding was observed as well as evident internalization of the radiolabeled peptide after binding. Biodistribution experiments showed rapid, specific localization of (KH)(2)-CCK8 on A431-CCK2R xenografts compared with control tun-tors, although absolute uptake values were not markedly higher compared with background activity. Clearance of unbound radioactivity was both urinary and hepatobiliary. In imaging experiments, while targeting to CCK2R positive tumors could be appreciated, there was poor contrast between target and nontarget areas. (KH)2-CCK8 shows adequate in vitro and in vivo properties for CCK2R targeting although improvement of biodistribution warrant further development. (C) 2008 Wiley Periodicals, Inc.
In vivo and in vitro characterization of CCK8 bearing a histidine-based chelator labeled with Tc-99m-tricarbonyl
Schutz K, Alecsandru D, Grimbacher B, Haddock J, Bruining A, Driessen G, De Vries E, Van Hagen PM, Hartmann I, Fraioli F, Milito C, Mitrevski M, Quinti I, Serra G, Kelleher P, Loebinger M, Litzman J, Postranecka V, Thon V, Babar J, Condliffe AM, Exley A, Kumararatne D, Screaton N, Jones A, Bondioni MP, Lougaris V, Plebani A, Soresina A, Sirignano C, Spadaro G, Galal N, Gonzalez-granado LI, Dettmer S, Stirling R, Chapel H, Lucas M, Patel S, Farber CM, Meyts I, Banerjee AK, Hackett S, Hurst JR, Warnatz K, Gathmann B, Weidemann J, Berthold D, Baumann U * Correction to: Imaging of Bronchial Pathology in Antibody Deficiency: Data from the European Chest CT Group(110 visite) J Clin Immunol (ISSN: 0271-9142linking, 1573-2592), 2019 Feb; 39(2): 225-227. Impact Factor:2.654 DettagliEsporta in BibTeXEsporta in EndNote
Schutz K, Alecsandru D, Grimbacher B, Haddock J, Bruining A, Driessen G, De Vries E, Van Hagen PM, Hartmann I, Fraioli F, Milito C, Mitrevski M, Quinti I, Serra G, Kelleher P, Loebinger M, Litzman J, Postranecka V, Thon V, Babar J, Condliffe AM, Exley A, Kumararatne D, Screaton N, Jones A, Bondioni MP, Lougaris V, Plebani A, Soresina A, Sirignano C, Spadaro G, Galal N, Gonzalez-granado LI, Dettmer S, Stirling R, Chapel H, Lucas M, Patel S, Farber CM, Meyts I, Banerjee AK, Hackett S, Hurst JR, Warnatz K, Gathmann B, Weidemann J, Berthold D, Baumann U, Schutz K, Alecsandru D, Grimbacher B, Haddock J, Bruining A, Driessen G, De Vries E, Van Hagen PM, Hartmann I, Fraioli F, Milito C, Mitrevski M, Quinti I, Serra G, Kelleher P, Loebinger M, Litzman J, Postranecka V, Thon V, Babar J, Condliffe AM, Exley A, Kumararatne D, Screaton N, Jones A, Bondioni MP, Lougaris V, Plebani A, Soresina A, Sirignano C, Spadaro G, Galal N, Gonzalez-granado LI, Dettmer S, Stirling R, Chapel H, Lucas M, Patel S, Farber CM, Meyts I, B * Imaging of Bronchial Pathology in Antibody Deficiency: Data from the European Chest CT Group(123 visite) J Clin Immunol (ISSN: 0271-9142linking, 1573-2592), 2019 Jan; 3939(2): 45-54. Impact Factor:2.654 DettagliEsporta in BibTeXEsporta in EndNote
Antonini A, Vitale C, Barone P, Cilia R, Righini A, Bonuccelli U, Abbruzzese G, Ramat S, Petrone A, Quatrale R, Marconi R, Ceravolo R, Stefani A, Lopiano L, Zappia M, Capus L, Morgante L, Tamma F, Tinazzi M, Colosimo C, Guerra UP, Valzania F, Fagioli G, Distefano A, Bagnato A, Feggi L, Anna S, Maria Teresa Rosaria De Cr, Nobili F, Mazzuca N, Baldari S, Eleopra R, Bestetti A, Benti R, Varrone A, Volterrani D, Massa R, Stocchi F, Schillaci O, Dore F, Zibetti M, Castellano G, Battista SG, Giorgetti G * The relationship between cerebral vascular disease and parkinsonism: The VADO study(422 visite) Parkinsonism Relat D (ISSN: 1353-8020, 1873-5126, 1873-5126electronic), 2012; 18(6): 775-780. Impact Factor:3.274 DettagliEsporta in BibTeXEsporta in EndNote
Malvindi MA, Greco A, Conversano F, Figuerola A, Corti M, Bonora M, Lascialfari A, Doumari HA, Moscardini M, Cingolani R, Gigli G, Casciaro S, Pellegrino T, Ragusa A * MR Contrast Agents(230 visite) Small Animal Imaging, 2011 Jul 8; 21(13): 2548-2555. Impact Factor:1.784 DettagliEsporta in BibTeXEsporta in EndNote
Ntziachristos V, Cuénod CA, Fournier L, Balvay D, Pradel C, Siauve N, Clement O, Jouannot E, Lucidarme O, Vecchio SD, Salvatore M, Law B, Tung C-H, Jain RK, Fukumura D, Munn LL, Brown EB, Schellenberger E, Montet X, Weissleder R, Clerck ND, Postnov A * Tumor Imaging(299 visite) Textbook Of In Vivo Imaging In Vertebrates (ISSN: 9780-4700), 2007 Jul 16; 1: 277-309. Impact Factor:1.148 DettagliEsporta in BibTeXEsporta in EndNote
Cusanno F, Cisbani E, Colilli S, Fratoni R, Garibaldi F, Giuliani F, Gricia M, Lucentini M, Magliozzi ML, Santarivenere F, Torrioli S, Cinti MN, Pani R, Pellegrini R, Simonetti G, Schillaci O, Del Vecchio S, Salvatore M, Majewski S, De Vincentis G, Scopinaro F * Results of clinical trials with SPEM(236 visite) Nucl Instrum Methods Phys Res Sect A, 2007 Feb 1; 497(1): 46-50. Impact Factor:3.221 DettagliEsporta in BibTeXEsporta in EndNote
Hesse B, Tagil K, Cuocolo A, Anagnostopoulos C, Bardies M, Bax J, Bengel F, Busemann Sokole E, Davies G, Dondi M, Edenbrandt L, Franken P, Kjaer A, Knuuti J, Lassmann M, Ljungberg M, Marcassa C, Marie PY, Mckiddie F, O'connor M, Prvuolovich E, Underwood R * 3. 0 T perfusion MR imaging(551 visite) Rivista Di Neuroradiologia (ISSN: 1120-9976), 2004; 17(6): 807-812. Impact Factor:0.023 DettagliEsporta in BibTeXEsporta in EndNote