Interleukin (il)-6 And Receptor Activator Of Nuclear Factor (nf)-Kappab Ligand (rankl) Are Increased In The Serum Of A Patient With Primary Pachydermoperiostosis
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Interleukin (il)-6 And Receptor Activator Of Nuclear Factor (nf)-Kappab Ligand (rankl) Are Increased In The Serum Of A Patient With Primary Pachydermoperiostosis (128 visite)

Rendina D, De Filippo G, Viceconti R, Soscia E, Sirignano C, Salvatore M, Della Monica M, Scarano G, Mossetti G

Scand J Rheumatol (ISSN: 0300-9742), 2008 May; 37(3): 225-229.



Tipo di articolo: Journal Article,

Impact factor: 2.345, Impact factor a 5 anni: 2.455

Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-45549109228&partnerID=40&md5=852d3bd9b96f832855dd67049b0ef53b

Parole chiave: Interleukin 6, Osteoclast Differentiation Factor, Tnfsf11 Protein, Human, Alkaline Phosphatase Bone Isoenzyme, Colchicine, Nonsteroid Antiinflammatory Agent, Technetium 99m, Adolescent, Article, Blood, Case Report, Osteoarthropathy, Radiography, Scintiscanning, Adult, Anamnesis, Bone Scintiscanning, Bone Turnover, Capillaroscopy, Clinical Feature, Hormone Blood Level, Nuclear Magnetic Resonance Imaging, Osteolysis, Physical Examination, Primary Pachydermoperiostosis, Priority Journal, Primary Hypertrophic, Rank Ligand,

Affiliazioni:

*** IBB - CNR ***
Department of Clinical and Experimental Medicine, 'Federico II' University Medical School, Naples, Italy
Paediatric Endocrinology Unit, A.O.R.N. 'G. Rummo', Benevento, Italy
Department of Biomorphological and Functional Science, Department of Diagnostic Imaging and Radiotherapy, 'Federico II' University Medical School, Naples, Italy
National Research Council (CNR) Biostructures and Bioimaging Institute, 'Federico II' University Medical School, Naples, Italy
Medical Genetics Unit, A.O.R.N. 'G. Rummo', Benevento, Italy


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Silveira, L. H., Martinez-Lavin, M., Pineda, C., Fonseca, M. C., Navarro, C., Nava, A., Vascular endothelial growth factor and hypertrophic osteoarthropathy (2000) Clin Exp Rheumatol, 18, pp. 57-62

Fam, A. G., Chin-Sang, H., Ramsay, C. A., Pachydermoperiostosis: Scintigraphic, thermographic, plethysmographic, and capillaroscopic observations (1983) Ann Rheum Dis, 42, pp. 98-102

Kallen, K. J., The role of transsignalling via the agonistic soluble IL-6 receptor in human diseases (2002) Biochim Biophys Acta, 1592, pp. 323-334

Boyle, W. J., Simonet, W. S., Lacey, D. L., Osteoclast differentiation and activation (2003) Nature, 423, pp. 337-342

Jones, S. A., Rose-John, S., The role of soluble receptors in cytokine biology: The agonistic properties of the sIL-6R/IL-6 complex (2002) Biochim Biophys Acta, 1592, pp. 251-263

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Brandi, M. L., Collin-Osdoby, P., Vascular biology and the skeleton (2006) J Bone Miner Res, 21, pp. 183-192

Roodman, G. D., Treatment strategies for bone disease (2007) Bone Marrow Transplant, 4, pp. 1139-1146



Primary pachydermoperiostosis (PDP) is a rare syndrome, characterized by digital clubbing, periostosis, and pachydermia. We have evaluated biochemical bone turnover markers, including components of interleukin-6 (IL-6) and osteoprotegerin/receptor activator of nuclear factor (NF)-κB ligand (OPG/RANKL) systems, in an 18-year-old man affected by primary PDP. The acute phase of the disease was characterized in our patient by high serum levels of IL-6 and RANKL. The observed high serum levels of these parameters are associated with increased values in markers of bone resorption (degradation products of C-terminal telopeptides of type-I collagen and urinary hydroxyproline/creatinine ratio) and reduced serum levels of bone alkaline phosphatase, a marker of bone formation. Serum levels of osteotrophic hormones were in the normal range. Our data suggest that, despite the radiographic findings, the acute phase of primary PDP is characterized by increased bone resorption, probably mediated by IL-6 and RANKL. © 2008 Taylor & Francis on license from Scandinavian Rheumatology Research Foundation.
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Pace L, Cuocolo A, Nicolai E, Imbriaco M, Maurea S, Nappi A, Ricciardelli B, Salvatore M
REVERSE REDISTRIBUTION IN TL-201 STRESS-REDISTRIBUTION MYOCARDIAL SCINTIGRAPHY - EFFECT OF REST REINJECTION (117 visite)
Clin Nucl Med (ISSN: 0363-9762, 1536-0229, 1536-0229electronic), 1994 Nov; 19(11): 956-961.
Impact Factor: 0.34
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Maurea S, Cuocolo A, Pace L, Nicolai E, Nappi A, Imbriaco M, Trimarco B, Salvatore M
Left ventricular dysfunction in coronary artery disease: Comparison between rest-redistribution thallium 201 and resting technetium 99m methoxyisobutyl isonitrile cardiac imaging (126 visite)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 1994 Jan; 1(1): 65-71.
Impact Factor: 1.878
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Imbriaco M, Cuocolo A, Pace L, Nicolai E, Nappi A, Celentano L,  Palma G, Vosa C
Technetium-99m methoxy isobutyl isonitrile simultaneous evaluation of ventricular function and myocardial perfusion in patients with congenital heart disease (113 visite)
Clin Nucl Med (ISSN: 0363-9762, 1536-0229, 1536-0229electronic), 1994 Jan; 19(1): 28-32.
Impact Factor: 0.34
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Nappi A, Cuocolo A, Iazzetta N, Ferrara LA, Marotta T, Pace L, Nicolai E, De Michele G, Campanella G, Salvatore M, Postiglione A
Ambulatory monitoring of left ventricular function in patients with Parkinson's disease and postural hypotension (151 visite)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1994; 21(12): 1312-1317.
Impact Factor: 2.692
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Maurea S, Cuocolo A, Pace L, Nicolai E, Nappi A, Imbriaco M, Morisco C, Chiariello M, Trimarco B, Salvatore M
Rest-injected thallium-201 redistribution and resting technetium-99m methoxyisobutylisonitrile uptake in coronary artery disease: relation to the severity of coronary artery stenosis (114 visite)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1993 Jun; 20(6): 502-510.
Impact Factor: 2.692
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Mangoni Di Stefano SML, Pace L, Betocchi S, Imbriaco M, Cuocolo A, Chiariello M, Salvatore M
Left ventricular function related to age: Radionuclide angiography (91 visite)
Ital Curr Radiol (ISSN: 0394-1574), 1992; 11(1-2): 13-16.
Impact Factor: 0
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Pace L, Cuocolo A, Nappi A, Nicolai E, Imbriaco M, Mangoni di Santo Stefano ML, Salvatore M
Myocardial scintigraphy with technetium 99m methoxyisobutylisonitrile. A comparison with coronary arteriography in patients with suspected ischemic cardiopathy (101 visite)
Radiol Med (ISSN: 1826-6983, 0033-8362, 1826-6983electronic), 1992; 83(1-2): 97-100.
Impact Factor: 0.967
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Alfano B, Betocchi S, Pace L, Perrone-Filardi P, Chiariello M, Salvatore M
Quantitation of left ventricular asynchrony on radionuclide angiography phase images (147 visite) (PDF 117 visite)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1990 Jul; 16(11): 801-806.
Impact Factor: 2.692
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Vosa C, Lapenta L, Caianiello G, Esposito V,  de LucaL, D'Angelo TS, Salvatore M
Pre- and postoperative Tc 99m scanning in monitoring pulmonary perfusion in the tetralogy of Fallot (83 visite)
Ital J Surg Sci (ISSN: 0392-3525), 1984; 14(1): 21-24.
Impact Factor: 0
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47 Records (46 escludendo Abstract e Conferenze).
Impact factor totale: 110.22 (107.812 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 130.169 (127.711 escludendo Abstract e Conferenze).







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