Peptide-containing aggregates as selective nanocarriers for therapeutics (362 views)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2008 Apr; 3(4): 594-602.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 3.15, 5-year impact factor: 3.15
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-47249093699&partnerID=40&md5=7ee0adeb62fc391b7ae3d953996816a7
Keywords: Cck8 Peptide, Drug Delivery, Dynamic Light Scattering, Small Angle Neutron Scattering, Supramolecular Aggregates, Cholecystokinin, Cholecystokinin Octapeptide, Diagnostic Agent, Drug Carrier, Indium, Nanomaterial, Peptide Fragment, Animal, Article, Chemistry, Cryoelectron Microscopy, Female, Micelle, Mouse, Radiation Scattering, Tissue Distribution, Indium Radioisotopes, Nanostructures,
Affiliations:
*** IBB - CNR ***
Department of Chemistry, University of Naples Federico II, Via Cynthia, 80126 Napoli, Italy
CIRPeB, Department of Biological Sciences, University of Naples Federico II, Via Mezzocannone 16, 80134 Napoli, Italy
Department of Nuclear Medicine, Istituto Nazionale per lo Studio e la Cura dei Tumouri, Fondazione G. Pascale, Via M. Semmola, 80131 Napoli, Italy
Department of Animal Experimentation, Istituto Nazionale per lo Studio e la Cura dei Tumouri, Fondazione G. Pascale, Via M. Semmola, 80131 Napoli, Italy
References:
Langer, R., (1998) Nature, 392, pp. 5-1
Torchilin, V.P., (2005) Nat. Rev. Drug Discovery, 4, pp. 145-160
Ferrari, M., (2005) Nat. Rev. Cancer, 5, pp. 161-217
Allen, M.T., (2002) Nat. Rev. Cancer, 2, pp. 750-763
Lobo, E.D., Hansen, R.J., Balthasar, J.P., (2004) J. Pharm. Sci, 93, pp. 2645-2668
Aloj, L., Morelli, G., (2004) Curr. Pharm. Des, 10, pp. 3009-3031
Kwekkeboom, D., Krenning, E.P., De Jong, M., (2000) J. Nucl. Med, 41, pp. 1704-1713
Lamberts, S.W., Krenning, E.P., Reubi, J.C., (1991) Endocr. Rev, 12, pp. 450-482
Mulder, W.J.M., Strijkers, G.J., van Tilborg, G.A.F., Griffioen, A.W., Nicolay, K., (2006) NMR Biomed, 19, pp. 142-164
Accardo, A., Tesauro, D., Roscigno, P., Gianolio, E., Paduano, L., D'Errico, G., Pedone, C., Morelli, G., (2004) J. Am. Chem. Soc, 126, pp. 3097-3107
Tesauro, D., Accardo, A., Gianolio, E., Paduano, L., Texeira, J., Schillén, K., Aime, S., Morelli, G., (2007) ChemBioChem, 8, pp. 950-955
Mierke, D.F., Giragossian, C., (2001) Med. Res. Rev, 21, pp. 450-471
Reubi, J.C., Schaer, J.C., Waser, B., (1997) Cancer Res, 57, pp. 1377-1386
Torchilin, V.P., Omelyanenko, V.G., Papisov, M.I., Bogdanov, A.J., Trubetskoy, V.S., Herron, J.N., Gentry, C.A., (1994) Biochim. Biophys. Acta Biomembr, 1195, pp. 11-20
Trubetskoy, V.S., Torchilin, V.P., (1995) Adv. Drug Delivery Rev, 16, pp. 311-320
Liu, S., Edwards, D.S., (2001) Bioconjugate Chem, 12, pp. 7-34
Moghimi, S.M., Hunter, A.C., Murray, J.C., (2001) Pharmacol. Rev, 53, pp. 283-318
Vaccaro, M., Accardo, A., Tesauro, D., Mangiapia, G., Löf, D., Schillén, K., Söderman, O., Paduano, L., (2006) Langmuir, 22, pp. 6635-6643
Feigin, L.A., Svergun, D.I., (1987) Structure analysis by small-angle X-ray and neutron scattering, , Plenum, New York
Mangiapia, G., Accardo, A., LoCelso, F., Tesauro, D., Morelli, G., Radulescu, A., Paduano, L., (2004) J. Phys. Chem. B, 108, pp. 17611-17617
Vergara, A., Paduano, L., Vitagliano, V., Sartorio, R., (1999) Phys. Chem. Chem. Phys, 1, pp. 5377-5383
Aloj, L., Jagoda, E., Lang, L., Caraco, C., Neumann, R.D., Sung, C., Eckelman, W.C., (1999) J. Nucl. Med, 40, pp. 1547-1555
Fritze, A., Hens, F., Kimpfler, A., Schubert, R., Peschka-Süss, R., (2006) Biochim. Biophys. Acta Biomembr, 1758, pp. 1633-1640
Aloj, L., Caraco, C., Panico, M., Zannetti, A., Del Vecchio, S., Tesauro, D., De Luca, S., Salvatore, M., (2004) J. Nucl. Med, 45, pp. 485-494
Schmitt, L., Dietrich, C., (1994) J. Am. Chem. Soc, 116, pp. 8485-8491
Chang, W.C., White, P.D., (2000) Fmoc solid phase peptide synthesis, , Oxford University Press, Oxford
Kotlarchyk, A.M., Chen, S.H., (1983) J. Chem. Phys, 79, pp. 2461-2469
Schwahn, B.D., Richter, D., Lin, M., Fetters, L.J., Lewis, J., (2002) Macromolecules, 35, pp. 3762-3768
Ma, C.G., Barlow, D.J., Lawrence, M.J., Heenan, R.K., Timmins, P., (2000) J. Phys. Chem. B, 104, pp. 9081-9085
Jansson, J., Schillén, K., Olofsson, G., Cardoso da Silva, R., Loh, W.J.J., (2004) J. Phys. Chem. B, 108, pp. 82-92
Berne, B.J., Pecora, R., (2000) Dynamic Light Scattering: With Application to Chemistry, Biology and Physics, , Dover Mineola, New York
Young, R.J., Lovell, P.A., (1996) Introduction to Polymers, , Chapman & Hall, London
Stepánek, P., (1993) Dynamic Light Scattering, , Ed, W. Brown, Oxford University Press, Oxford
Johnsen, R., Brown, W., Bloomfield, (1992) Laser Light Scattering in Biochemistry, p. 77. , Eds, S. E. Harding, D. B. Sattelle, Royal Society of Chemistry, Cambridge
Glatter, O., Scherf, G., Schillén, K., Brown, W., (1994) Macromolecules, 27, pp. 6046-6054
Almgren, M., Edwards, K., Gustafsson, J.J., (1996) Curr. Opin. Colloid Interface Sci, 1, pp. 270-278
Skehan, P., Storeng, R., Scudiero, D., Monks, A., McMahon, J., Vistica, D., Warren, J.T., Boyd, M.R., (1990) J. Natl. Med. Assoc. J. Natl. Cancer Inst, 82, pp. 1107-1112
Torchilin, V. P., (2005) Nat. Rev. Drug Discovery, 4, pp. 145-160
Allen, M. T., (2002) Nat. Rev. Cancer, 2, pp. 750-763
Lobo, E. D., Hansen, R. J., Balthasar, J. P., (2004) J. Pharm. Sci, 93, pp. 2645-2668
Lamberts, S. W., Krenning, E. P., Reubi, J. C., (1991) Endocr. Rev, 12, pp. 450-482
Mulder, W. J. M., Strijkers, G. J., van Tilborg, G. A. F., Griffioen, A. W., Nicolay, K., (2006) NMR Biomed, 19, pp. 142-164
Mierke, D. F., Giragossian, C., (2001) Med. Res. Rev, 21, pp. 450-471
Reubi, J. C., Schaer, J. C., Waser, B., (1997) Cancer Res, 57, pp. 1377-1386
Torchilin, V. P., Omelyanenko, V. G., Papisov, M. I., Bogdanov, A. J., Trubetskoy, V. S., Herron, J. N., Gentry, C. A., (1994) Biochim. Biophys. Acta Biomembr, 1195, pp. 11-20
Trubetskoy, V. S., Torchilin, V. P., (1995) Adv. Drug Delivery Rev, 16, pp. 311-320
Moghimi, S. M., Hunter, A. C., Murray, J. C., (2001) Pharmacol. Rev, 53, pp. 283-318
Feigin, L. A., Svergun, D. I., (1987) Structure analysis by small-angle X-ray and neutron scattering, , Plenum, New York
Chang, W. C., White, P. D., (2000) Fmoc solid phase peptide synthesis, , Oxford University Press, Oxford
Kotlarchyk, A. M., Chen, S. H., (1983) J. Chem. Phys, 79, pp. 2461-2469
Schwahn, B. D., Richter, D., Lin, M., Fetters, L. J., Lewis, J., (2002) Macromolecules, 35, pp. 3762-3768
Ma, C. G., Barlow, D. J., Lawrence, M. J., Heenan, R. K., Timmins, P., (2000) J. Phys. Chem. B, 104, pp. 9081-9085
Berne, B. J., Pecora, R., (2000) Dynamic Light Scattering: With Application to Chemistry, Biology and Physics, , Dover Mineola, New York
Young, R. J., Lovell, P. A., (1996) Introduction to Polymers, , Chapman & Hall, London
Step nek, P., (1993) Dynamic Light Scattering, , Ed, W. Brown, Oxford University Press, Oxford
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2008 Apr; 3(4): 594-602.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 3.15, 5-year impact factor: 3.15
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-47249093699&partnerID=40&md5=7ee0adeb62fc391b7ae3d953996816a7
Keywords: Cck8 Peptide, Drug Delivery, Dynamic Light Scattering, Small Angle Neutron Scattering, Supramolecular Aggregates, Cholecystokinin, Cholecystokinin Octapeptide, Diagnostic Agent, Drug Carrier, Indium, Nanomaterial, Peptide Fragment, Animal, Article, Chemistry, Cryoelectron Microscopy, Female, Micelle, Mouse, Radiation Scattering, Tissue Distribution, Indium Radioisotopes, Nanostructures,
Affiliations:
*** IBB - CNR ***
Department of Chemistry, University of Naples Federico II, Via Cynthia, 80126 Napoli, Italy
CIRPeB, Department of Biological Sciences, University of Naples Federico II, Via Mezzocannone 16, 80134 Napoli, Italy
Department of Nuclear Medicine, Istituto Nazionale per lo Studio e la Cura dei Tumouri, Fondazione G. Pascale, Via M. Semmola, 80131 Napoli, Italy
Department of Animal Experimentation, Istituto Nazionale per lo Studio e la Cura dei Tumouri, Fondazione G. Pascale, Via M. Semmola, 80131 Napoli, Italy
References:
Langer, R., (1998) Nature, 392, pp. 5-1
Torchilin, V.P., (2005) Nat. Rev. Drug Discovery, 4, pp. 145-160
Ferrari, M., (2005) Nat. Rev. Cancer, 5, pp. 161-217
Allen, M.T., (2002) Nat. Rev. Cancer, 2, pp. 750-763
Lobo, E.D., Hansen, R.J., Balthasar, J.P., (2004) J. Pharm. Sci, 93, pp. 2645-2668
Aloj, L., Morelli, G., (2004) Curr. Pharm. Des, 10, pp. 3009-3031
Kwekkeboom, D., Krenning, E.P., De Jong, M., (2000) J. Nucl. Med, 41, pp. 1704-1713
Lamberts, S.W., Krenning, E.P., Reubi, J.C., (1991) Endocr. Rev, 12, pp. 450-482
Mulder, W.J.M., Strijkers, G.J., van Tilborg, G.A.F., Griffioen, A.W., Nicolay, K., (2006) NMR Biomed, 19, pp. 142-164
Accardo, A., Tesauro, D., Roscigno, P., Gianolio, E., Paduano, L., D'Errico, G., Pedone, C., Morelli, G., (2004) J. Am. Chem. Soc, 126, pp. 3097-3107
Tesauro, D., Accardo, A., Gianolio, E., Paduano, L., Texeira, J., Schillén, K., Aime, S., Morelli, G., (2007) ChemBioChem, 8, pp. 950-955
Mierke, D.F., Giragossian, C., (2001) Med. Res. Rev, 21, pp. 450-471
Reubi, J.C., Schaer, J.C., Waser, B., (1997) Cancer Res, 57, pp. 1377-1386
Torchilin, V.P., Omelyanenko, V.G., Papisov, M.I., Bogdanov, A.J., Trubetskoy, V.S., Herron, J.N., Gentry, C.A., (1994) Biochim. Biophys. Acta Biomembr, 1195, pp. 11-20
Trubetskoy, V.S., Torchilin, V.P., (1995) Adv. Drug Delivery Rev, 16, pp. 311-320
Liu, S., Edwards, D.S., (2001) Bioconjugate Chem, 12, pp. 7-34
Moghimi, S.M., Hunter, A.C., Murray, J.C., (2001) Pharmacol. Rev, 53, pp. 283-318
Vaccaro, M., Accardo, A., Tesauro, D., Mangiapia, G., Löf, D., Schillén, K., Söderman, O., Paduano, L., (2006) Langmuir, 22, pp. 6635-6643
Feigin, L.A., Svergun, D.I., (1987) Structure analysis by small-angle X-ray and neutron scattering, , Plenum, New York
Mangiapia, G., Accardo, A., LoCelso, F., Tesauro, D., Morelli, G., Radulescu, A., Paduano, L., (2004) J. Phys. Chem. B, 108, pp. 17611-17617
Vergara, A., Paduano, L., Vitagliano, V., Sartorio, R., (1999) Phys. Chem. Chem. Phys, 1, pp. 5377-5383
Aloj, L., Jagoda, E., Lang, L., Caraco, C., Neumann, R.D., Sung, C., Eckelman, W.C., (1999) J. Nucl. Med, 40, pp. 1547-1555
Fritze, A., Hens, F., Kimpfler, A., Schubert, R., Peschka-Süss, R., (2006) Biochim. Biophys. Acta Biomembr, 1758, pp. 1633-1640
Aloj, L., Caraco, C., Panico, M., Zannetti, A., Del Vecchio, S., Tesauro, D., De Luca, S., Salvatore, M., (2004) J. Nucl. Med, 45, pp. 485-494
Schmitt, L., Dietrich, C., (1994) J. Am. Chem. Soc, 116, pp. 8485-8491
Chang, W.C., White, P.D., (2000) Fmoc solid phase peptide synthesis, , Oxford University Press, Oxford
Kotlarchyk, A.M., Chen, S.H., (1983) J. Chem. Phys, 79, pp. 2461-2469
Schwahn, B.D., Richter, D., Lin, M., Fetters, L.J., Lewis, J., (2002) Macromolecules, 35, pp. 3762-3768
Ma, C.G., Barlow, D.J., Lawrence, M.J., Heenan, R.K., Timmins, P., (2000) J. Phys. Chem. B, 104, pp. 9081-9085
Jansson, J., Schillén, K., Olofsson, G., Cardoso da Silva, R., Loh, W.J.J., (2004) J. Phys. Chem. B, 108, pp. 82-92
Berne, B.J., Pecora, R., (2000) Dynamic Light Scattering: With Application to Chemistry, Biology and Physics, , Dover Mineola, New York
Young, R.J., Lovell, P.A., (1996) Introduction to Polymers, , Chapman & Hall, London
Stepánek, P., (1993) Dynamic Light Scattering, , Ed, W. Brown, Oxford University Press, Oxford
Johnsen, R., Brown, W., Bloomfield, (1992) Laser Light Scattering in Biochemistry, p. 77. , Eds, S. E. Harding, D. B. Sattelle, Royal Society of Chemistry, Cambridge
Glatter, O., Scherf, G., Schillén, K., Brown, W., (1994) Macromolecules, 27, pp. 6046-6054
Almgren, M., Edwards, K., Gustafsson, J.J., (1996) Curr. Opin. Colloid Interface Sci, 1, pp. 270-278
Skehan, P., Storeng, R., Scudiero, D., Monks, A., McMahon, J., Vistica, D., Warren, J.T., Boyd, M.R., (1990) J. Natl. Med. Assoc. J. Natl. Cancer Inst, 82, pp. 1107-1112
Torchilin, V. P., (2005) Nat. Rev. Drug Discovery, 4, pp. 145-160
Allen, M. T., (2002) Nat. Rev. Cancer, 2, pp. 750-763
Lobo, E. D., Hansen, R. J., Balthasar, J. P., (2004) J. Pharm. Sci, 93, pp. 2645-2668
Lamberts, S. W., Krenning, E. P., Reubi, J. C., (1991) Endocr. Rev, 12, pp. 450-482
Mulder, W. J. M., Strijkers, G. J., van Tilborg, G. A. F., Griffioen, A. W., Nicolay, K., (2006) NMR Biomed, 19, pp. 142-164
Mierke, D. F., Giragossian, C., (2001) Med. Res. Rev, 21, pp. 450-471
Reubi, J. C., Schaer, J. C., Waser, B., (1997) Cancer Res, 57, pp. 1377-1386
Torchilin, V. P., Omelyanenko, V. G., Papisov, M. I., Bogdanov, A. J., Trubetskoy, V. S., Herron, J. N., Gentry, C. A., (1994) Biochim. Biophys. Acta Biomembr, 1195, pp. 11-20
Trubetskoy, V. S., Torchilin, V. P., (1995) Adv. Drug Delivery Rev, 16, pp. 311-320
Moghimi, S. M., Hunter, A. C., Murray, J. C., (2001) Pharmacol. Rev, 53, pp. 283-318
Feigin, L. A., Svergun, D. I., (1987) Structure analysis by small-angle X-ray and neutron scattering, , Plenum, New York
Chang, W. C., White, P. D., (2000) Fmoc solid phase peptide synthesis, , Oxford University Press, Oxford
Kotlarchyk, A. M., Chen, S. H., (1983) J. Chem. Phys, 79, pp. 2461-2469
Schwahn, B. D., Richter, D., Lin, M., Fetters, L. J., Lewis, J., (2002) Macromolecules, 35, pp. 3762-3768
Ma, C. G., Barlow, D. J., Lawrence, M. J., Heenan, R. K., Timmins, P., (2000) J. Phys. Chem. B, 104, pp. 9081-9085
Berne, B. J., Pecora, R., (2000) Dynamic Light Scattering: With Application to Chemistry, Biology and Physics, , Dover Mineola, New York
Young, R. J., Lovell, P. A., (1996) Introduction to Polymers, , Chapman & Hall, London
Step nek, P., (1993) Dynamic Light Scattering, , Ed, W. Brown, Oxford University Press, Oxford
Peptide-containing aggregates as selective nanocarriers for therapeutics
New nanocarriers are obtained by assembling two amphiphilic monomers: one containing the bioactive peptide CCK8 spaced, by a polydisperse poly(ethylene glycol), from two hydrophobic tails ((C18)2PEG2000CCK8), and the other containing a chelating agent able to give stable radiolabeled indium-111 complexes linked to the same hydrophobic moiety ((C18)2DTPAGlu). The size and shape of the supramolecular aggregates were structurally characterized by dynamic light scattering, small-angle neutron scattering, and cryogenic transmission electronic microscopy. Under the experimental conditions we investigated (pH 7.4 and molar ratio between monomers 30:70), there is the presence of high polydisperse aggregates: rod-like micelles with a radius of ∼40 Å and length >700 Å, open bilayer fragments with thickness ∼65 Å, and probably vesicles. The presence of the bioactive peptide well exposed on the external surface of the aggregate allows selective targeting of nanocarriers towards the cholecystokinin receptors overexpressed by the cancerous cells. In vitro binding assays and in vivo biodistribution studies by nuclear medicine experiments using indium-111 are reported. Moreover, preliminary data concerning the drug loading capability of the aggregates and their drug efficiency on the target cells is reported by using the cytotoxic drug doxorubicin. Incubation of receptor-positive and control cells with peptide-containing aggregates filled with doxorubicin shows significantly lower cell survival in receptor-expressing cells relative to the control, for samples incubated in the presence of doxorubicin. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
New nanocarriers are obtained by assembling two amphiphilic monomers: one containing the bioactive peptide CCK8 spaced, by a polydisperse poly(ethylene glycol), from two hydrophobic tails ((C18)2PEG2000CCK8), and the other containing a chelating agent able to give stable radiolabeled indium-111 complexes linked to the same hydrophobic moiety ((C18)2DTPAGlu). The size and shape of the supramolecular aggregates were structurally characterized by dynamic light scattering, small-angle neutron scattering, and cryogenic transmission electronic microscopy. Under the experimental conditions we investigated (pH 7.4 and molar ratio between monomers 30:70), there is the presence of high polydisperse aggregates: rod-like micelles with a radius of ∼40 Å and length >700 Å, open bilayer fragments with thickness ∼65 Å, and probably vesicles. The presence of the bioactive peptide well exposed on the external surface of the aggregate allows selective targeting of nanocarriers towards the cholecystokinin receptors overexpressed by the cancerous cells. In vitro binding assays and in vivo biodistribution studies by nuclear medicine experiments using indium-111 are reported. Moreover, preliminary data concerning the drug loading capability of the aggregates and their drug efficiency on the target cells is reported by using the cytotoxic drug doxorubicin. Incubation of receptor-positive and control cells with peptide-containing aggregates filled with doxorubicin shows significantly lower cell survival in receptor-expressing cells relative to the control, for samples incubated in the presence of doxorubicin. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
Peptide-containing aggregates as selective nanocarriers for therapeutics
Peptide-containing aggregates as selective nanocarriers for therapeutics
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Impact Factor: 3.455
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Galdiero S, Falanga A, Morelli G, Galdiero M
* gH625: A milestone in understanding the many roles of membranotropic peptides (479 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2015 Jan; 1848(PA): 16-25.
Impact Factor: 5.158
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Roviello GN, Musumeci D, Roviello V
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Impact Factor: 3.994
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Nardon C, Boscutti G, Dalla Via L, Ringhieri P, Di Noto V, Morelli G, Accardo A, Fregona D
* CCK8 peptide-labeled Pluronic® F127 micelles as a targeted vehicle of gold-based anticancer chemotherapeutics (363 views)
Medchemcomm (ISSN: 2040-2503), 2015; 6(1): 155-163.
Impact Factor: 2.319
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Vitiello G, Falanga A, Petruk AA, Merlino A, Fragneto G, Paduano L, Galdiero S, D'Errico G
* Fusion of raft-like lipid bilayers operated by a membranotropic domain of the HSV-type I glycoprotein gH occurs through a cholesterol-dependent mechanism (357 views)
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Impact Factor: 3.798
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Avitabile C, Accardo A, Ringhieri P, Morelli G, Saviano M, Montagner G, Fabbri E, Gallerani E, Gambari R, Romanelli A
* Incorporation of Naked Peptide Nucleic Acids into Liposomes Leads to Fast and Efficient Delivery (421 views)
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Impact Factor: 4.5
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Ringhieri P, Diaferia C, Galdiero S, Palumbo R, Morelli G, Accardo A
* Liposomal doxorubicin doubly functionalized with CCK8 and R8 peptide sequences for selective intracellular drug delivery (432 views)
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Impact Factor: 1.951
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Ringhieri P, Iannitti R, Nardon C, Palumbo R, Fregona D, Morelli G, Accardo A
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Impact Factor: 3.65
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Capasso D, De Paola I, Liguoro A, Del Gatto A, Di Gaetano S, Guarnieri D, Saviano M, Zaccaro L
* Rgdechi-Hcit: Alpha V Beta 3 Selective Pro-Apoptotic Peptide As Potential Carrier For Drug Delivery Into Melanoma Metastatic Cells (431 views)
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Impact Factor: 3.234
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Oliveri V, Attanasio F, Puglisi A, Spencer J, Sgarlata C, Vecchio G
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Impact Factor: 5.731
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Galdiero S, Falanga A, Vitiello M, Grieco P, Caraglia M, Morelli G, Galdiero M
* Exploitation of viral properties for intracellular delivery (465 views)
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Impact Factor: 1.546
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Accardo A, Ringhieri P, Szekely N, Pipich V, Luchini A, Paduano L, Tesauro D
* Structural insights on nanoparticles containing gadolinium complexes as potential theranostic (410 views)
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Impact Factor: 1.865
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Accardo A, Ringhieri P, Palumbo R, Morelli G
* Influence of PEG length on conformational and binding properties of CCK peptides exposed by supramolecular aggregates (365 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2014 Apr; 101(4): 304-312.
Impact Factor: 2.385
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Accardo A, Aloj L, Aurilio M, Morelli G, Tesauro D
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Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1176-9114linking), 2014 Mar 27; 9(1): 1537-1557.
Impact Factor: 4.383
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Roviello GN, Roviello GN, Musumeci D, Capasso D, Di Gaetano S, Costanzo M, Pedone C
* Synthesis and supramolecular assembly of 1, 3-bis(1 '-uracilyl)-2-propanone (372 views)
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Impact Factor: 3.84
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Alterio V, Pan P, Parkkila S, Buonanno M, Supuran CT, Monti SM, De Simone G
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Impact Factor: 2.385
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Clemente F, Arpaia P, Manna C
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Measurement (ISSN: 0263-2241), 2013 Nov; 46(9): 3494-3501.
Impact Factor: 1.526
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Pica A, Merlino A, Buell AK, Knowles TJ, Pizzo E, D'Alessio G, Sica F, Mazzarella L
* Three-dimensional domain swapping and supramolecular protein assembly: insights from the X-ray structure of a dimeric swapped variant of human pancreatic RNase (847 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2013 Oct; 69: 2116-2123.
Impact Factor: 7.232
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Galdiero S, Falanga A, Cantisani M, Vitiello M, Morelli G, Galdiero M
* Peptide-Lipid Interactions: Experiments and Applications (950 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067electronic), 2013 Sep; 14(9): 18758-18789.
Impact Factor: 2.339
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Nande R, Greco A, Gossman MS, Lopez JP, Claudio L, Salvatore M, Brunetti A, Denvir J, Howard CM, Claudio PP
* Microbubble-assisted p53, RB, and p130 gene transfer in combination with radiation therapy in prostate cancer (430 views)
Current Gene Therapy (ISSN: 1875-5631, 1566-5232), 2013 Jun 1; 13(3): 163-174.
Impact Factor: 4.906
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Falciani C, Brunetti J, Lelli B, Accardo A, Tesauro D, Morelli G, Bracci L
* Nanoparticles exposing neurotensin tumor-specific drivers (407 views)
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Impact Factor: 1.862
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Accardo A, Mangiapia G, Paduano L, Morelli G, Tesauro D
* Octreotide labeled aggregates containing platinum complexes as nanovectors for drug delivery (374 views)
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Impact Factor: 1.862
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Calce E, Monfregola L, Sandomenico A, Saviano M, De Luca S
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Impact Factor: 3.432
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Travaglia A, Satriano C, Giuffrida ML, La Mendola D, Rampazzo E, Prodi L, Rizzarelli E
* Electrostatically driven interaction of silica-supported lipid bilayer nanoplatforms and a nerve growth factor-mimicking peptide (305 views)
Soft Matter (ISSN: 1744-683x), 2013; 9(18): 4648-4654.
Impact Factor: 4.151
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Smaldone G, Falanga A, Capasso D, Guarnieri D, Correale S, Galdiero M, Netti PA, Zollo M, Galdiero S, Di Gaetano S, Pedone E
* gH625 is a viral derived peptide for effective delivery of intrinsically disordered proteins (414 views)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1178-2013electronic), 2013; 8: 2555-2565.
Impact Factor: 4.195
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Berisio R
* Learning from pathogens: Exploiting host-pathogen liaison for therapeutic development (364 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2012 Dec; 13(8): 697-698.
Impact Factor: 2.326
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Accardo A, Mansi R, Salzano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Ziaco B, Tesauro D, Aloj L, De Rosa G, Morelli G
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Impact Factor: 2.768
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Roviello GN, Roviello G, Musumeci D, Bucci EM, Pedone C
* Dakin-West reaction on 1-thyminyl acetic acid for the synthesis of 1, 3-bis(1-thyminyl)-2-propanone, a heteroaromatic compound with nucleopeptide-binding properties (398 views)
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Impact Factor: 3.914
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Galdiero S, Vitiello M, Falanga A, Cantisani M, Incoronato N, Galdiero M
* Intracellular Delivery: Exploiting Viral Membranotropic Peptides (650 views)
Current Drug Metabolism (ISSN: 1389-2002), 2012 Jan; 13(1): 93-104.
Impact Factor: 4.405
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Accardo A, Salsano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Tesauro D, Aloj L, De Rosa G, Morelli G
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Int J Nanomed (ISSN: 1176-9114, 1178-2013, 1178-2013electronic), 2012; 7: 2007-2017.
Impact Factor: 3.463
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Falanga A, Vitiello MT, Cantisani M, Tarallo R, Guarnieri D, Mignogna E, Netti P, Pedone C, Galdiero M, Galdiero S
* A peptide derived from herpes simplex virus type 1 glycoprotein H: membrane translocation and applications to the delivery of quantum dots (822 views)
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Impact Factor: 6.692
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Tarallo R, Accardo A, Falanga A, Guarnieri D, Vitiello G, Netti P, D'Errico G, Morelli G, Galdiero S
* Clickable functionalization of liposomes with the gH625 peptide from herpes simplex virus type i for intracellular drug delivery (441 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Nov 4; 17(45): 12659-12668.
Impact Factor: 5.925
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Tornesello AL, Aurilio M, Accardo A, Tarallo L, Barbieri A, Arra C, Tesauro D, Morelli G, Aloj L
* Gastrin and cholecystokinin peptide-based radiopharmaceuticals: An in vivo and in vitro comparison (370 views)
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Impact Factor: 1.799
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Falciani C, Accardo A, Brunetti J, Tesauro D, Lelli B, Pini A, Bracci L, Morelli G
* Target-Selective Drug Delivery through Liposomes Labeled with Oligobranched Neurotensin Peptides (512 views)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2011 Apr 4; 6(4): 678-685.
Impact Factor: 3.151
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Accardo A, Morisco A, Palladino P, Palumbo R, Tesauro D, Morelli G
* Amphiphilic CCK peptides assembled in supramolecular aggregates: Structural investigations and in vitro studies (466 views)
Mol Biosyst (ISSN: 1742-206x), 2011 Mar; 7(3): 862-870.
Impact Factor: 3.534
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Accardo A, Morisco A, Gianolio E, Tesauro D, Mangiapia G, Radulescu A, Brandt A, Morelli G
* Nanoparticles containing octreotide peptides and gadolinium complexes for MRI applications (484 views)
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Impact Factor: 1.799
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Accardo A, Morisco A, Tesauro D, Pedone C, Morelli G
* Naposomes: A new class of peptide-derivatized, target-selective multimodal nanoparticles for imaging and therapeutic applications (400 views)
Ther Deliv (ISSN: 2041-5990), 2011 Feb; 2(2): 235-257.
Impact Factor: 0
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Morisco A, Accardo A, Tesauro D, Palumbo R, Benedetti E, Morelli G
* Peptide-labeled supramolecular aggregates as selective doxorubicin carriers for delivery to tumor cells (351 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2011; 96(1): 88-96.
Impact Factor: 2.87
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Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment: Challenges and perspectives (574 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 249-258.
Impact Factor: 1.724
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Moccia M, Musumeci D, Roviello GN, Fusco S, Valente M, Bucci EM, Sapio R, Pedonea C, Netti PA
* Preliminary studies on noncovalent hyperbranched polymers based on PNA and DNA building blocks (593 views)
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Impact Factor: 1.807
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Accardo A, Tesauro D, Aloj L, Pedone C, Morelli G
* Supramolecular aggregates containing lipophilic Gd(III) complexes as contrast agents in MRI (578 views)
Coord Chem Rev (ISSN: 0010-8545), 2009 Sep; 253(17-18): 2193-2213.
Impact Factor: 11.225
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Accardo A, Tesauro D, Morisco A, Mangiapia G, Vaccaro M, Gianolio E, Heenan RK, Paduano L, Morelli G
* Micelles obtained by aggregation of gemini surfactants containing the CCK8 peptide and a gadolinium complex (384 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257linking), 2009 May; 14(4): 587-599.
Impact Factor: 3.415
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Zaccaro L, Del Gatto A, Pedone C, Saviano M
* Peptides for tumour therapy and diagnosis: current status and future directions (908 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2009 Mar; 16(7): 780-795.
Impact Factor: 4.708
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Vaccaro M, Mangiapia G, Radulescu A, Schillen K, D'Errico G, Morelli G, Paduano L
* Colloidal particles composed of amphiphilic molecules binding gadolinium complexes and peptides as tumor-specific contrast agents in MRI: physico-chemical characterization (500 views)
Soft Matter (ISSN: 1744-683x), 2009; 5(13): 2504-2512.
Impact Factor: 4.869
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Accardo A, Tesauro D, Morelli G, Del Pozzo L, Pedone C, Tornesello AL, Benedetti E
* Supramolecular aggregates derivatized by CCK8 peptide as selective nanocarriers for drug delivery (342 views)
Adv Exp Med Biol (ISSN: 0065-2598, 0065-2598print), 2009; 611: 603-604.
Impact Factor: 2.02
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Vaccaro M, Mangiapia G, Accardo A, Tesauro D, Gianolio E, Frielinghaus H, Morelli G, Paduano L
* Polymerized mixed aggregates containing gadolinium complex and CCK8 peptide (346 views)
Colloid Polym Sci (ISSN: 0303-402x), 2008 Dec; 286(14-15): 1643-1652.
Impact Factor: 1.736
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Marasco D, Perretta G, Sabatella M, Ruvo M
* Past and Future Perspectives of Synthetic Peptide Libraries (512 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2008 Oct; 9(5): 447-467.
Impact Factor: 3.011
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Accardo A, Tesauro D, Del Pozzo L, Mangiapia G, Paduano L, Morelli G
* Micelles by self-assembling peptide-conjugate amphiphile: Synthesis and structural characterization (379 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): 903-910.
Impact Factor: 1.654
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Accardo A, Tesauro D, Benedetti E, Pedone C, Morelli G
* Naposomes: A new class of peptide containing supramolecular aggregates as target selective delivery systems (233 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
Impact Factor: 1.654
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Zeni O, Palumbo R, Bernini R, Zeni L, Sarti M, Scarfi MR
* Cytotoxicity investigation on cultured human blood cells treated with single-wall carbon nanotubes (297 views)
Sensors (ISSN: 1424-3210, 1424-8220, 1424-8220electronic), 2008 Jan; 8(1): 488-499.
Impact Factor: 1.87
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Maggi A, Salvatore M
Molecular imaging (318 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 95-95.
Impact Factor: 1.724
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Del Vecchio S, Zannetti A, Fonti R, Pace L, Salvatore M
* Nuclear imaging in cancer theranostics (592 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 152-163.
Impact Factor: 1.724
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Agostini S, Bolzati C, Didonè E, Cavazza-Ceccato M, Refosco F, Aloj L, Arra C, Aurilio M, Tornesello AL, Tesauro D, Morelli G
* The (Tc(N)(PNP))2+ metal fragment labeled cholecystokinin-8 (CCK8) peptide for CCK-2 receptors imaging: In vitro and in vivo studies (372 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2007 Apr; 13(4): 211-219.
Impact Factor: 1.768
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Accardo A, Tesauro D, Morelli G, Gianolio E, Aime S, Vaccaro M, Mangiapia G, Paduano L, Schillén K
* High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI (391 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2007 Feb; 12(2): 267-276.
Impact Factor: 3.325
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Accardo A, Tesauro D, Mangiapia G, Pedone C, Morelli G
* Nanostructures by self-assembling peptide amphiphile as potential selective drug carriers (414 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2007; 88(2): 115-121.
Impact Factor: 2.389
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Vaccaro M, Accardo A, Tesauro D, Mangiapia G, Loef D, Schillen K, Soederman O, Morelli G, Paduan L
* Supramolecular aggregates of amphiphilic gadolinium complexes as blood pool MRI/MRA contrast agents: Physicochemical characterization (380 views)
Langmuir (ISSN: 0743-7463), 2006 Jul 18; 22(15): 6635-6643.
Impact Factor: 3.902
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Pappalardo M, Milardi D, Grasso D, La Rosa C
* Phase behaviour of polymer-grafted DPPC membranes for drug delivery systems design (294 views)
Journal Of Thermal Analysis And Calorimetry (ISSN: 1388-6150), 2005 May; 80(2): 413-418.
Impact Factor: 1.425
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De Luca S, Sanseverino M, Zocchi I, Pedone C, Morelli G, Ragone R
* Receptor fragment approach to the binding between CCK8 peptide and cholecystokinin receptors: A fluorescence study on type B receptor fragment CCKB-R (352-379) (333 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2005 Mar; 77(4): 205-211.
Impact Factor: 2.545
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Cortesi R, Mischiati C, Borgatti M, Breda L, Romanelli A, Saviano M, Pedone C, Gambari R, Nastruzzi C
* Formulations for natural and peptide nucleic acids based on cationic polymeric submicron particles (370 views)
The Aaps Journal (ISSN: 1522-1059, 1550-7416), 2004 Jan 20; 6(1): N/D-N/D.
Impact Factor: 1.938
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Borgatti M, Breda L, Cortesi R, Nastruzzi C, Romanelli A, Saviano M, Bianchi N, Mischiati C, Pedone C, Gambari R
* Cationic Liposomes As Delivery Systems For Double-Stranded Pna-Dna Chimeras Exhibiting Decoy Activity Against Nf-Kappab Transcription Factors (393 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 1873-2968, 0006-2952), 2002 Sep 15; 64(4): 609-616.
Impact Factor: 3.542
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Morelli G, De Luca S, Tesauro D, Saviano M, Pedone C, Dolmella A, Visentin R, Mazzi U
* CCK8 peptide derivatized with diphenylphosphine for rhenium labelling: Synthesis and molecular mechanics calculations (307 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2002 Jul; 8(7): 373-381.
Impact Factor: 1.691
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Aloj L, Zannetti A, Caraco C, Del Vecchio S, Tasauro D, De Luca S, Brunetti A, Aime S, Morelli G, Pedone C
* Characterization of 111In labeled CCK8 peptide coupled to a novel DTPA-like derivative in CCK-B receptor overexpressing cells (364 views)
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Impact Factor: 3.464
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* Human Serum Albumin Nanoparticles as a Carrier for On-Demand Sorafenib Delivery (14 views)
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Impact Factor: 2.097
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Doti N, Mardirossian M, Sandomenico A, Ruvo M, Caporale A
* Recent Applications of Retro-Inverso Peptides (18 views)
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Impact Factor: 4.556
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Agnello L, Tortorella S, D’argenio A, Carbone C, Camorani S, Locatelli E, Auletta L, Sorrentino D, Fedele M, Zannetti A, Franchini MC, Cerchia L
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Impact Factor: 11.161
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Di Somma A, Avitabile C, Cirillo A, Moretta A, Merlino A, Paduano L, Duilio A, Romanelli A
* The antimicrobial peptide Temporin L impairs E. coli cell division by interacting with FtsZ and the divisome complex (54 views)
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Impact Factor: 3.422
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Roviello GN
* Novel insights into nucleoamino acids: biomolecular recognition and aggregation studies of a thymine-conjugated L-phenyl alanine (366 views)
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Impact Factor: 3.173
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Honarvar H, Calce E, Doti N, Langella E, Orlova A, Buijs J, D’amato V, Bianco R, Saviano M, Tolmachev V, De Luca S
* Evaluation of HER2-specific peptide ligand for its employment as radiolabeled imaging probe (277 views)
Sci Rep (ISSN: 2045-2322linking, 2045-2322electronic), 2018 Feb 14; 8(1): 2998-2998.
Impact Factor: 4.259
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Riccardi C, Musumeci D, Capuozzo A, Irace C, King S, Russo Krauss I, Paduano L, Montesarchio D
* "dressing up" an Old Drug: An Aminoacyl Lipid for the Functionalization of Ru(III)-Based Anticancer Agents (185 views)
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Impact Factor: 0
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Gaglione R, Smaldone G, Di Girolamo R, Piccoli R, Pedone E, Arciello A
* Cell milieu significantly affects the fate of AApoAI amyloidogenic variants: predestination or serendipity? (326 views)
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 1570-9639print), 2017 Nov 23; 1862(3): 377-384.
Impact Factor: 4.28
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Caraci F, Bruno V, Copani A, Matrisciano F, Nicoletti F, Battaglia G
* The impact of metabotropic glutamate receptors into active neurodegenerative processes: A "dark side" in the development of new symptomatic treatments for neurologic and psychiatric disorders (276 views)
Neuropharm (ISSN: 0028-3908, 1873-7064electronic, 0028-3908linking), 2017 Mar 15; 115: 180-192.
Impact Factor: 5.012
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Greco A, Albanese S, Auletta L, De Carlo F, Salvatore M, Howard CM, Claudio PP
* Advances in molecular preclinical therapy mediated by imaging (255 views) (PDF 205 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1827-1936), 2017 Mar; 61(1): 76-94.
Impact Factor: 2.368
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Oliveri V, Bellia F, Vecchio G
* Cyclodextrin Nanoparticles Bearing 8-Hydroxyquinoline Ligands as Multifunctional Biomaterials (654 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2017; 23(18): 4442-4449.
Impact Factor: 5.16
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Accardo A, Arena F, Gianolio E, Marasco D, Ringhieri P, Boffa C, Bardini P, Aime S, Morelli G
* Diolein based nanostructures as targeted theranostics (416 views)
J Biomed Nanotechnol (ISSN: 1550-7033), 2016; 12(5): 1076-1088.
Impact Factor: 4.521
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Ringhieri P, Pannunzio A, Boccarelli A, Morelli G, Coluccia M, Tesauro D
* Effect of cisplatin containing liposomes formulated by unsaturated chain-containing lipids on gynecological tumor cells (265 views)
J Liposome Res (ISSN: 0898-2104), 2016; N/D: 1-6.
Impact Factor: 1.971
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Ringhieri P, Avitabile C, Saviano M, Morelli G, Romanelli A, Accardo A
* The influence of liposomal formulation on the incorporation and retention of PNA oligomers (159 views)
Colloid Surface B (ISSN: 0927-7765), 2016; 145: 462-469.
Impact Factor: 3.887
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Vincenzi M, Accardo A, Costantini S, Scala S, Portella L, Trotta A, Ronga L, Guillon J, Leone M, Colonna G, Rossi F, Tesauro D
* Intrinsically disordered amphiphilic peptides as potential targets in drug delivery vehicles (375 views)
Mol Biosyst (ISSN: 1742-206x), 2015 Oct 13; 11(11): 2925-2932.
Impact Factor: 2.829
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Calce E, Monfregola L, Saviano M, De Luca S
* HER2-mediated anticancer drug delivery: strategies to prepare targeting ligands highly specific for the receptor (538 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2015 May 20; 22(21): 2525-2538.
Impact Factor: 3.455
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Galdiero S, Falanga A, Morelli G, Galdiero M
* gH625: A milestone in understanding the many roles of membranotropic peptides (479 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2015 Jan; 1848(PA): 16-25.
Impact Factor: 5.158
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Roviello GN, Musumeci D, Roviello V
* Cationic peptides as RNA compaction agents: A study on the polyA compaction activity of a linear alpha, epsilon-oligo-l-lysine (461 views)
Int J Pharm (ISSN: 0378-5173, 1873-3476), 2015; 485(1-2): 244-248.
Impact Factor: 3.994
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Nardon C, Boscutti G, Dalla Via L, Ringhieri P, Di Noto V, Morelli G, Accardo A, Fregona D
* CCK8 peptide-labeled Pluronic® F127 micelles as a targeted vehicle of gold-based anticancer chemotherapeutics (363 views)
Medchemcomm (ISSN: 2040-2503), 2015; 6(1): 155-163.
Impact Factor: 2.319
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Vitiello G, Falanga A, Petruk AA, Merlino A, Fragneto G, Paduano L, Galdiero S, D'Errico G
* Fusion of raft-like lipid bilayers operated by a membranotropic domain of the HSV-type I glycoprotein gH occurs through a cholesterol-dependent mechanism (357 views)
Soft Matter (ISSN: 1744-683x), 2015; 11(15): 3003-3016.
Impact Factor: 3.798
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Avitabile C, Accardo A, Ringhieri P, Morelli G, Saviano M, Montagner G, Fabbri E, Gallerani E, Gambari R, Romanelli A
* Incorporation of Naked Peptide Nucleic Acids into Liposomes Leads to Fast and Efficient Delivery (421 views)
Bioconjug Chem (ISSN: 1043-1802, 1520-4812), 2015; 26(8): 1533-1541.
Impact Factor: 4.5
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Ringhieri P, Diaferia C, Galdiero S, Palumbo R, Morelli G, Accardo A
* Liposomal doxorubicin doubly functionalized with CCK8 and R8 peptide sequences for selective intracellular drug delivery (432 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617linking), 2015; 21(5): 415-425.
Impact Factor: 1.951
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Ringhieri P, Iannitti R, Nardon C, Palumbo R, Fregona D, Morelli G, Accardo A
* Target selective micelles for bombesin receptors incorporating Au(III)-dithiocarbamato complexes (373 views)
Int J Pharm (ISSN: 0378-5173, 1873-3476), 2014 Oct 1; 473(1-2): 194-202.
Impact Factor: 3.65
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Capasso D, De Paola I, Liguoro A, Del Gatto A, Di Gaetano S, Guarnieri D, Saviano M, Zaccaro L
* Rgdechi-Hcit: Alpha V Beta 3 Selective Pro-Apoptotic Peptide As Potential Carrier For Drug Delivery Into Melanoma Metastatic Cells (431 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2014 Sep 23; 9(9): e106441-e106441.
Impact Factor: 3.234
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Oliveri V, Attanasio F, Puglisi A, Spencer J, Sgarlata C, Vecchio G
* Multifunctional 8-hydroxyquinoline-appended cyclodextrins as new inhibitors of metal-induced protein aggregation (538 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2014 Jul 14; 20(29): 8954-8964.
Impact Factor: 5.731
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Galdiero S, Falanga A, Vitiello M, Grieco P, Caraglia M, Morelli G, Galdiero M
* Exploitation of viral properties for intracellular delivery (465 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617linking), 2014 Jul; 20(7): 468-478.
Impact Factor: 1.546
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Accardo A, Ringhieri P, Szekely N, Pipich V, Luchini A, Paduano L, Tesauro D
* Structural insights on nanoparticles containing gadolinium complexes as potential theranostic (410 views)
Colloid Polym Sci (ISSN: 0303-402x), 2014 May; 292(5): 1121-1127.
Impact Factor: 1.865
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Accardo A, Ringhieri P, Palumbo R, Morelli G
* Influence of PEG length on conformational and binding properties of CCK peptides exposed by supramolecular aggregates (365 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2014 Apr; 101(4): 304-312.
Impact Factor: 2.385
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Accardo A, Aloj L, Aurilio M, Morelli G, Tesauro D
* Receptor binding peptides for target-selective delivery of nanoparticles encapsulated drugs (534 views)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1176-9114linking), 2014 Mar 27; 9(1): 1537-1557.
Impact Factor: 4.383
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Roviello GN, Roviello GN, Musumeci D, Capasso D, Di Gaetano S, Costanzo M, Pedone C
* Synthesis and supramolecular assembly of 1, 3-bis(1 '-uracilyl)-2-propanone (372 views)
Rsc Adv (ISSN: 2046-2069), 2014; 4(54): 28691-28698.
Impact Factor: 3.84
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Alterio V, Pan P, Parkkila S, Buonanno M, Supuran CT, Monti SM, De Simone G
* The Structural Comparison Between Membrane-Associated Human Carbonic Anhydrases Provides Insights Into Drug Design Of Selective Inhibitors (387 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2014; 101(7): 769-778.
Impact Factor: 2.385
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Clemente F, Arpaia P, Manna C
* Characterization of human skin impedance after electrical treatment for transdermal drug delivery (351 views)
Measurement (ISSN: 0263-2241), 2013 Nov; 46(9): 3494-3501.
Impact Factor: 1.526
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Pica A, Merlino A, Buell AK, Knowles TJ, Pizzo E, D'Alessio G, Sica F, Mazzarella L
* Three-dimensional domain swapping and supramolecular protein assembly: insights from the X-ray structure of a dimeric swapped variant of human pancreatic RNase (847 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2013 Oct; 69: 2116-2123.
Impact Factor: 7.232
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Galdiero S, Falanga A, Cantisani M, Vitiello M, Morelli G, Galdiero M
* Peptide-Lipid Interactions: Experiments and Applications (950 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067electronic), 2013 Sep; 14(9): 18758-18789.
Impact Factor: 2.339
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Nande R, Greco A, Gossman MS, Lopez JP, Claudio L, Salvatore M, Brunetti A, Denvir J, Howard CM, Claudio PP
* Microbubble-assisted p53, RB, and p130 gene transfer in combination with radiation therapy in prostate cancer (430 views)
Current Gene Therapy (ISSN: 1875-5631, 1566-5232), 2013 Jun 1; 13(3): 163-174.
Impact Factor: 4.906
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Falciani C, Brunetti J, Lelli B, Accardo A, Tesauro D, Morelli G, Bracci L
* Nanoparticles exposing neurotensin tumor-specific drivers (407 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Apr; 19(4): 198-204.
Impact Factor: 1.862
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Accardo A, Mangiapia G, Paduano L, Morelli G, Tesauro D
* Octreotide labeled aggregates containing platinum complexes as nanovectors for drug delivery (374 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Apr; 19(4): 190-197.
Impact Factor: 1.862
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Calce E, Monfregola L, Sandomenico A, Saviano M, De Luca S
* Fluorescence study for selecting specific ligands toward HER2 receptor: An example of receptor fragment approach (403 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2013 Mar; 61: 116-121.
Impact Factor: 3.432
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Travaglia A, Satriano C, Giuffrida ML, La Mendola D, Rampazzo E, Prodi L, Rizzarelli E
* Electrostatically driven interaction of silica-supported lipid bilayer nanoplatforms and a nerve growth factor-mimicking peptide (305 views)
Soft Matter (ISSN: 1744-683x), 2013; 9(18): 4648-4654.
Impact Factor: 4.151
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Smaldone G, Falanga A, Capasso D, Guarnieri D, Correale S, Galdiero M, Netti PA, Zollo M, Galdiero S, Di Gaetano S, Pedone E
* gH625 is a viral derived peptide for effective delivery of intrinsically disordered proteins (414 views)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1178-2013electronic), 2013; 8: 2555-2565.
Impact Factor: 4.195
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Berisio R
* Learning from pathogens: Exploiting host-pathogen liaison for therapeutic development (364 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2012 Dec; 13(8): 697-698.
Impact Factor: 2.326
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Accardo A, Mansi R, Salzano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Ziaco B, Tesauro D, Aloj L, De Rosa G, Morelli G
* Bombesin peptide antagonist for target-selective delivery of liposomal doxorubicin on cancer cells (380 views)
Journal Of Drug Targeting (ISSN: 1061-186x), 2012 Nov 21; 21(3): 240-249.
Impact Factor: 2.768
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Roviello GN, Roviello G, Musumeci D, Bucci EM, Pedone C
* Dakin-West reaction on 1-thyminyl acetic acid for the synthesis of 1, 3-bis(1-thyminyl)-2-propanone, a heteroaromatic compound with nucleopeptide-binding properties (398 views)
Amino Acids (ISSN: 1438-2199, 0939-4451, 1438-2199electronic), 2012 Oct; 43(4): 1615-1623.
Impact Factor: 3.914
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Galdiero S, Vitiello M, Falanga A, Cantisani M, Incoronato N, Galdiero M
* Intracellular Delivery: Exploiting Viral Membranotropic Peptides (650 views)
Current Drug Metabolism (ISSN: 1389-2002), 2012 Jan; 13(1): 93-104.
Impact Factor: 4.405
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Accardo A, Salsano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Tesauro D, Aloj L, De Rosa G, Morelli G
* Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells: A potential theranostic agent (349 views)
Int J Nanomed (ISSN: 1176-9114, 1178-2013, 1178-2013electronic), 2012; 7: 2007-2017.
Impact Factor: 3.463
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Falanga A, Vitiello MT, Cantisani M, Tarallo R, Guarnieri D, Mignogna E, Netti P, Pedone C, Galdiero M, Galdiero S
* A peptide derived from herpes simplex virus type 1 glycoprotein H: membrane translocation and applications to the delivery of quantum dots (822 views)
Nanomedicine (ISSN: 1549-9642, 1549-9634, 1549-9642electronic), 2011 Dec; 7(6): 925-934.
Impact Factor: 6.692
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Tarallo R, Accardo A, Falanga A, Guarnieri D, Vitiello G, Netti P, D'Errico G, Morelli G, Galdiero S
* Clickable functionalization of liposomes with the gH625 peptide from herpes simplex virus type i for intracellular drug delivery (441 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Nov 4; 17(45): 12659-12668.
Impact Factor: 5.925
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Tornesello AL, Aurilio M, Accardo A, Tarallo L, Barbieri A, Arra C, Tesauro D, Morelli G, Aloj L
* Gastrin and cholecystokinin peptide-based radiopharmaceuticals: An in vivo and in vitro comparison (370 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 May; 17(5): 405-412.
Impact Factor: 1.799
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Falciani C, Accardo A, Brunetti J, Tesauro D, Lelli B, Pini A, Bracci L, Morelli G
* Target-Selective Drug Delivery through Liposomes Labeled with Oligobranched Neurotensin Peptides (512 views)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2011 Apr 4; 6(4): 678-685.
Impact Factor: 3.151
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Accardo A, Morisco A, Palladino P, Palumbo R, Tesauro D, Morelli G
* Amphiphilic CCK peptides assembled in supramolecular aggregates: Structural investigations and in vitro studies (466 views)
Mol Biosyst (ISSN: 1742-206x), 2011 Mar; 7(3): 862-870.
Impact Factor: 3.534
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Accardo A, Morisco A, Gianolio E, Tesauro D, Mangiapia G, Radulescu A, Brandt A, Morelli G
* Nanoparticles containing octreotide peptides and gadolinium complexes for MRI applications (484 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 Feb; 17(2): 154-162.
Impact Factor: 1.799
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Accardo A, Morisco A, Tesauro D, Pedone C, Morelli G
* Naposomes: A new class of peptide-derivatized, target-selective multimodal nanoparticles for imaging and therapeutic applications (400 views)
Ther Deliv (ISSN: 2041-5990), 2011 Feb; 2(2): 235-257.
Impact Factor: 0
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Morisco A, Accardo A, Tesauro D, Palumbo R, Benedetti E, Morelli G
* Peptide-labeled supramolecular aggregates as selective doxorubicin carriers for delivery to tumor cells (351 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2011; 96(1): 88-96.
Impact Factor: 2.87
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Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment: Challenges and perspectives (574 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 249-258.
Impact Factor: 1.724
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Moccia M, Musumeci D, Roviello GN, Fusco S, Valente M, Bucci EM, Sapio R, Pedonea C, Netti PA
* Preliminary studies on noncovalent hyperbranched polymers based on PNA and DNA building blocks (593 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Oct; 15(10): 647-653.
Impact Factor: 1.807
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Accardo A, Tesauro D, Aloj L, Pedone C, Morelli G
* Supramolecular aggregates containing lipophilic Gd(III) complexes as contrast agents in MRI (578 views)
Coord Chem Rev (ISSN: 0010-8545), 2009 Sep; 253(17-18): 2193-2213.
Impact Factor: 11.225
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Accardo A, Tesauro D, Morisco A, Mangiapia G, Vaccaro M, Gianolio E, Heenan RK, Paduano L, Morelli G
* Micelles obtained by aggregation of gemini surfactants containing the CCK8 peptide and a gadolinium complex (384 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257linking), 2009 May; 14(4): 587-599.
Impact Factor: 3.415
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Zaccaro L, Del Gatto A, Pedone C, Saviano M
* Peptides for tumour therapy and diagnosis: current status and future directions (908 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2009 Mar; 16(7): 780-795.
Impact Factor: 4.708
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Vaccaro M, Mangiapia G, Radulescu A, Schillen K, D'Errico G, Morelli G, Paduano L
* Colloidal particles composed of amphiphilic molecules binding gadolinium complexes and peptides as tumor-specific contrast agents in MRI: physico-chemical characterization (500 views)
Soft Matter (ISSN: 1744-683x), 2009; 5(13): 2504-2512.
Impact Factor: 4.869
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Accardo A, Tesauro D, Morelli G, Del Pozzo L, Pedone C, Tornesello AL, Benedetti E
* Supramolecular aggregates derivatized by CCK8 peptide as selective nanocarriers for drug delivery (342 views)
Adv Exp Med Biol (ISSN: 0065-2598, 0065-2598print), 2009; 611: 603-604.
Impact Factor: 2.02
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Vaccaro M, Mangiapia G, Accardo A, Tesauro D, Gianolio E, Frielinghaus H, Morelli G, Paduano L
* Polymerized mixed aggregates containing gadolinium complex and CCK8 peptide (346 views)
Colloid Polym Sci (ISSN: 0303-402x), 2008 Dec; 286(14-15): 1643-1652.
Impact Factor: 1.736
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Marasco D, Perretta G, Sabatella M, Ruvo M
* Past and Future Perspectives of Synthetic Peptide Libraries (512 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2008 Oct; 9(5): 447-467.
Impact Factor: 3.011
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Accardo A, Tesauro D, Del Pozzo L, Mangiapia G, Paduano L, Morelli G
* Micelles by self-assembling peptide-conjugate amphiphile: Synthesis and structural characterization (379 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): 903-910.
Impact Factor: 1.654
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Accardo A, Tesauro D, Benedetti E, Pedone C, Morelli G
* Naposomes: A new class of peptide containing supramolecular aggregates as target selective delivery systems (233 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
Impact Factor: 1.654
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Zeni O, Palumbo R, Bernini R, Zeni L, Sarti M, Scarfi MR
* Cytotoxicity investigation on cultured human blood cells treated with single-wall carbon nanotubes (297 views)
Sensors (ISSN: 1424-3210, 1424-8220, 1424-8220electronic), 2008 Jan; 8(1): 488-499.
Impact Factor: 1.87
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Maggi A, Salvatore M
Molecular imaging (318 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 95-95.
Impact Factor: 1.724
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Del Vecchio S, Zannetti A, Fonti R, Pace L, Salvatore M
* Nuclear imaging in cancer theranostics (592 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 152-163.
Impact Factor: 1.724
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Agostini S, Bolzati C, Didonè E, Cavazza-Ceccato M, Refosco F, Aloj L, Arra C, Aurilio M, Tornesello AL, Tesauro D, Morelli G
* The (Tc(N)(PNP))2+ metal fragment labeled cholecystokinin-8 (CCK8) peptide for CCK-2 receptors imaging: In vitro and in vivo studies (372 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2007 Apr; 13(4): 211-219.
Impact Factor: 1.768
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Accardo A, Tesauro D, Morelli G, Gianolio E, Aime S, Vaccaro M, Mangiapia G, Paduano L, Schillén K
* High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI (391 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2007 Feb; 12(2): 267-276.
Impact Factor: 3.325
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Accardo A, Tesauro D, Mangiapia G, Pedone C, Morelli G
* Nanostructures by self-assembling peptide amphiphile as potential selective drug carriers (414 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2007; 88(2): 115-121.
Impact Factor: 2.389
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Vaccaro M, Accardo A, Tesauro D, Mangiapia G, Loef D, Schillen K, Soederman O, Morelli G, Paduan L
* Supramolecular aggregates of amphiphilic gadolinium complexes as blood pool MRI/MRA contrast agents: Physicochemical characterization (380 views)
Langmuir (ISSN: 0743-7463), 2006 Jul 18; 22(15): 6635-6643.
Impact Factor: 3.902
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Pappalardo M, Milardi D, Grasso D, La Rosa C
* Phase behaviour of polymer-grafted DPPC membranes for drug delivery systems design (294 views)
Journal Of Thermal Analysis And Calorimetry (ISSN: 1388-6150), 2005 May; 80(2): 413-418.
Impact Factor: 1.425
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De Luca S, Sanseverino M, Zocchi I, Pedone C, Morelli G, Ragone R
* Receptor fragment approach to the binding between CCK8 peptide and cholecystokinin receptors: A fluorescence study on type B receptor fragment CCKB-R (352-379) (333 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2005 Mar; 77(4): 205-211.
Impact Factor: 2.545
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Cortesi R, Mischiati C, Borgatti M, Breda L, Romanelli A, Saviano M, Pedone C, Gambari R, Nastruzzi C
* Formulations for natural and peptide nucleic acids based on cationic polymeric submicron particles (370 views)
The Aaps Journal (ISSN: 1522-1059, 1550-7416), 2004 Jan 20; 6(1): N/D-N/D.
Impact Factor: 1.938
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Borgatti M, Breda L, Cortesi R, Nastruzzi C, Romanelli A, Saviano M, Bianchi N, Mischiati C, Pedone C, Gambari R
* Cationic Liposomes As Delivery Systems For Double-Stranded Pna-Dna Chimeras Exhibiting Decoy Activity Against Nf-Kappab Transcription Factors (393 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 1873-2968, 0006-2952), 2002 Sep 15; 64(4): 609-616.
Impact Factor: 3.542
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Morelli G, De Luca S, Tesauro D, Saviano M, Pedone C, Dolmella A, Visentin R, Mazzi U
* CCK8 peptide derivatized with diphenylphosphine for rhenium labelling: Synthesis and molecular mechanics calculations (307 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2002 Jul; 8(7): 373-381.
Impact Factor: 1.691
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Aloj L, Zannetti A, Caraco C, Del Vecchio S, Tasauro D, De Luca S, Brunetti A, Aime S, Morelli G, Pedone C
* Characterization of 111In labeled CCK8 peptide coupled to a novel DTPA-like derivative in CCK-B receptor overexpressing cells (364 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2001 Sep; 28(8): N/D-N/D.
Impact Factor: 3.464
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77 Records (71 excluding Abstracts).
Total impact factor: 256.171 (239.898 excluding Abstracts).
Total 5 year impact factor: 265.644 (243.663 excluding Abstracts).
Total impact factor: 256.171 (239.898 excluding Abstracts).
Total 5 year impact factor: 265.644 (243.663 excluding Abstracts).
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