Peptide-containing aggregates as selective nanocarriers for therapeutics (183 visite)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2008 Apr; 3(4): 594-602.
Tipo di articolo: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 3.15, Impact factor a 5 anni: 3.15
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-47249093699&partnerID=40&md5=7ee0adeb62fc391b7ae3d953996816a7
Parole chiave: Cck8 Peptide, Drug Delivery, Dynamic Light Scattering, Small Angle Neutron Scattering, Supramolecular Aggregates, Cholecystokinin, Cholecystokinin Octapeptide, Diagnostic Agent, Drug Carrier, Indium, Nanomaterial, Peptide Fragment, Animal, Article, Chemistry, Cryoelectron Microscopy, Female, Micelle, Mouse, Radiation Scattering, Tissue Distribution, Indium Radioisotopes, Nanostructures,
Affiliazioni:
*** IBB - CNR ***
Department of Chemistry, University of Naples Federico II, Via Cynthia, 80126 Napoli, Italy
CIRPeB, Department of Biological Sciences, University of Naples Federico II, Via Mezzocannone 16, 80134 Napoli, Italy
Department of Nuclear Medicine, Istituto Nazionale per lo Studio e la Cura dei Tumouri, Fondazione G. Pascale, Via M. Semmola, 80131 Napoli, Italy
Department of Animal Experimentation, Istituto Nazionale per lo Studio e la Cura dei Tumouri, Fondazione G. Pascale, Via M. Semmola, 80131 Napoli, Italy
Riferimenti:
Langer, R., (1998) Nature, 392, pp. 5-1
Torchilin, V.P., (2005) Nat. Rev. Drug Discovery, 4, pp. 145-160
Ferrari, M., (2005) Nat. Rev. Cancer, 5, pp. 161-217
Allen, M.T., (2002) Nat. Rev. Cancer, 2, pp. 750-763
Lobo, E.D., Hansen, R.J., Balthasar, J.P., (2004) J. Pharm. Sci, 93, pp. 2645-2668
Aloj, L., Morelli, G., (2004) Curr. Pharm. Des, 10, pp. 3009-3031
Kwekkeboom, D., Krenning, E.P., De Jong, M., (2000) J. Nucl. Med, 41, pp. 1704-1713
Lamberts, S.W., Krenning, E.P., Reubi, J.C., (1991) Endocr. Rev, 12, pp. 450-482
Mulder, W.J.M., Strijkers, G.J., van Tilborg, G.A.F., Griffioen, A.W., Nicolay, K., (2006) NMR Biomed, 19, pp. 142-164
Accardo, A., Tesauro, D., Roscigno, P., Gianolio, E., Paduano, L., D'Errico, G., Pedone, C., Morelli, G., (2004) J. Am. Chem. Soc, 126, pp. 3097-3107
Tesauro, D., Accardo, A., Gianolio, E., Paduano, L., Texeira, J., Schillén, K., Aime, S., Morelli, G., (2007) ChemBioChem, 8, pp. 950-955
Mierke, D.F., Giragossian, C., (2001) Med. Res. Rev, 21, pp. 450-471
Reubi, J.C., Schaer, J.C., Waser, B., (1997) Cancer Res, 57, pp. 1377-1386
Torchilin, V.P., Omelyanenko, V.G., Papisov, M.I., Bogdanov, A.J., Trubetskoy, V.S., Herron, J.N., Gentry, C.A., (1994) Biochim. Biophys. Acta Biomembr, 1195, pp. 11-20
Trubetskoy, V.S., Torchilin, V.P., (1995) Adv. Drug Delivery Rev, 16, pp. 311-320
Liu, S., Edwards, D.S., (2001) Bioconjugate Chem, 12, pp. 7-34
Moghimi, S.M., Hunter, A.C., Murray, J.C., (2001) Pharmacol. Rev, 53, pp. 283-318
Vaccaro, M., Accardo, A., Tesauro, D., Mangiapia, G., Löf, D., Schillén, K., Söderman, O., Paduano, L., (2006) Langmuir, 22, pp. 6635-6643
Feigin, L.A., Svergun, D.I., (1987) Structure analysis by small-angle X-ray and neutron scattering, , Plenum, New York
Mangiapia, G., Accardo, A., LoCelso, F., Tesauro, D., Morelli, G., Radulescu, A., Paduano, L., (2004) J. Phys. Chem. B, 108, pp. 17611-17617
Vergara, A., Paduano, L., Vitagliano, V., Sartorio, R., (1999) Phys. Chem. Chem. Phys, 1, pp. 5377-5383
Aloj, L., Jagoda, E., Lang, L., Caraco, C., Neumann, R.D., Sung, C., Eckelman, W.C., (1999) J. Nucl. Med, 40, pp. 1547-1555
Fritze, A., Hens, F., Kimpfler, A., Schubert, R., Peschka-Süss, R., (2006) Biochim. Biophys. Acta Biomembr, 1758, pp. 1633-1640
Aloj, L., Caraco, C., Panico, M., Zannetti, A., Del Vecchio, S., Tesauro, D., De Luca, S., Salvatore, M., (2004) J. Nucl. Med, 45, pp. 485-494
Schmitt, L., Dietrich, C., (1994) J. Am. Chem. Soc, 116, pp. 8485-8491
Chang, W.C., White, P.D., (2000) Fmoc solid phase peptide synthesis, , Oxford University Press, Oxford
Kotlarchyk, A.M., Chen, S.H., (1983) J. Chem. Phys, 79, pp. 2461-2469
Schwahn, B.D., Richter, D., Lin, M., Fetters, L.J., Lewis, J., (2002) Macromolecules, 35, pp. 3762-3768
Ma, C.G., Barlow, D.J., Lawrence, M.J., Heenan, R.K., Timmins, P., (2000) J. Phys. Chem. B, 104, pp. 9081-9085
Jansson, J., Schillén, K., Olofsson, G., Cardoso da Silva, R., Loh, W.J.J., (2004) J. Phys. Chem. B, 108, pp. 82-92
Berne, B.J., Pecora, R., (2000) Dynamic Light Scattering: With Application to Chemistry, Biology and Physics, , Dover Mineola, New York
Young, R.J., Lovell, P.A., (1996) Introduction to Polymers, , Chapman & Hall, London
Stepánek, P., (1993) Dynamic Light Scattering, , Ed, W. Brown, Oxford University Press, Oxford
Johnsen, R., Brown, W., Bloomfield, (1992) Laser Light Scattering in Biochemistry, p. 77. , Eds, S. E. Harding, D. B. Sattelle, Royal Society of Chemistry, Cambridge
Glatter, O., Scherf, G., Schillén, K., Brown, W., (1994) Macromolecules, 27, pp. 6046-6054
Almgren, M., Edwards, K., Gustafsson, J.J., (1996) Curr. Opin. Colloid Interface Sci, 1, pp. 270-278
Skehan, P., Storeng, R., Scudiero, D., Monks, A., McMahon, J., Vistica, D., Warren, J.T., Boyd, M.R., (1990) J. Natl. Med. Assoc. J. Natl. Cancer Inst, 82, pp. 1107-1112
Torchilin, V. P., (2005) Nat. Rev. Drug Discovery, 4, pp. 145-160
Allen, M. T., (2002) Nat. Rev. Cancer, 2, pp. 750-763
Lobo, E. D., Hansen, R. J., Balthasar, J. P., (2004) J. Pharm. Sci, 93, pp. 2645-2668
Lamberts, S. W., Krenning, E. P., Reubi, J. C., (1991) Endocr. Rev, 12, pp. 450-482
Mulder, W. J. M., Strijkers, G. J., van Tilborg, G. A. F., Griffioen, A. W., Nicolay, K., (2006) NMR Biomed, 19, pp. 142-164
Mierke, D. F., Giragossian, C., (2001) Med. Res. Rev, 21, pp. 450-471
Reubi, J. C., Schaer, J. C., Waser, B., (1997) Cancer Res, 57, pp. 1377-1386
Torchilin, V. P., Omelyanenko, V. G., Papisov, M. I., Bogdanov, A. J., Trubetskoy, V. S., Herron, J. N., Gentry, C. A., (1994) Biochim. Biophys. Acta Biomembr, 1195, pp. 11-20
Trubetskoy, V. S., Torchilin, V. P., (1995) Adv. Drug Delivery Rev, 16, pp. 311-320
Moghimi, S. M., Hunter, A. C., Murray, J. C., (2001) Pharmacol. Rev, 53, pp. 283-318
Feigin, L. A., Svergun, D. I., (1987) Structure analysis by small-angle X-ray and neutron scattering, , Plenum, New York
Chang, W. C., White, P. D., (2000) Fmoc solid phase peptide synthesis, , Oxford University Press, Oxford
Kotlarchyk, A. M., Chen, S. H., (1983) J. Chem. Phys, 79, pp. 2461-2469
Schwahn, B. D., Richter, D., Lin, M., Fetters, L. J., Lewis, J., (2002) Macromolecules, 35, pp. 3762-3768
Ma, C. G., Barlow, D. J., Lawrence, M. J., Heenan, R. K., Timmins, P., (2000) J. Phys. Chem. B, 104, pp. 9081-9085
Jansson, J., Schill n, K., Olofsson, G., Cardoso da Silva, R., Loh, W. J. J., (2004) J. Phys. Chem. B, 108, pp. 82-92
Berne, B. J., Pecora, R., (2000) Dynamic Light Scattering: With Application to Chemistry, Biology and Physics, , Dover Mineola, New York
Young, R. J., Lovell, P. A., (1996) Introduction to Polymers, , Chapman & Hall, London
Step nek, P., (1993) Dynamic Light Scattering, , Ed, W. Brown, Oxford University Press, Oxford
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2008 Apr; 3(4): 594-602.
Tipo di articolo: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 3.15, Impact factor a 5 anni: 3.15
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-47249093699&partnerID=40&md5=7ee0adeb62fc391b7ae3d953996816a7
Parole chiave: Cck8 Peptide, Drug Delivery, Dynamic Light Scattering, Small Angle Neutron Scattering, Supramolecular Aggregates, Cholecystokinin, Cholecystokinin Octapeptide, Diagnostic Agent, Drug Carrier, Indium, Nanomaterial, Peptide Fragment, Animal, Article, Chemistry, Cryoelectron Microscopy, Female, Micelle, Mouse, Radiation Scattering, Tissue Distribution, Indium Radioisotopes, Nanostructures,
Affiliazioni:
*** IBB - CNR ***
Department of Chemistry, University of Naples Federico II, Via Cynthia, 80126 Napoli, Italy
CIRPeB, Department of Biological Sciences, University of Naples Federico II, Via Mezzocannone 16, 80134 Napoli, Italy
Department of Nuclear Medicine, Istituto Nazionale per lo Studio e la Cura dei Tumouri, Fondazione G. Pascale, Via M. Semmola, 80131 Napoli, Italy
Department of Animal Experimentation, Istituto Nazionale per lo Studio e la Cura dei Tumouri, Fondazione G. Pascale, Via M. Semmola, 80131 Napoli, Italy
Riferimenti:
Langer, R., (1998) Nature, 392, pp. 5-1
Torchilin, V.P., (2005) Nat. Rev. Drug Discovery, 4, pp. 145-160
Ferrari, M., (2005) Nat. Rev. Cancer, 5, pp. 161-217
Allen, M.T., (2002) Nat. Rev. Cancer, 2, pp. 750-763
Lobo, E.D., Hansen, R.J., Balthasar, J.P., (2004) J. Pharm. Sci, 93, pp. 2645-2668
Aloj, L., Morelli, G., (2004) Curr. Pharm. Des, 10, pp. 3009-3031
Kwekkeboom, D., Krenning, E.P., De Jong, M., (2000) J. Nucl. Med, 41, pp. 1704-1713
Lamberts, S.W., Krenning, E.P., Reubi, J.C., (1991) Endocr. Rev, 12, pp. 450-482
Mulder, W.J.M., Strijkers, G.J., van Tilborg, G.A.F., Griffioen, A.W., Nicolay, K., (2006) NMR Biomed, 19, pp. 142-164
Accardo, A., Tesauro, D., Roscigno, P., Gianolio, E., Paduano, L., D'Errico, G., Pedone, C., Morelli, G., (2004) J. Am. Chem. Soc, 126, pp. 3097-3107
Tesauro, D., Accardo, A., Gianolio, E., Paduano, L., Texeira, J., Schillén, K., Aime, S., Morelli, G., (2007) ChemBioChem, 8, pp. 950-955
Mierke, D.F., Giragossian, C., (2001) Med. Res. Rev, 21, pp. 450-471
Reubi, J.C., Schaer, J.C., Waser, B., (1997) Cancer Res, 57, pp. 1377-1386
Torchilin, V.P., Omelyanenko, V.G., Papisov, M.I., Bogdanov, A.J., Trubetskoy, V.S., Herron, J.N., Gentry, C.A., (1994) Biochim. Biophys. Acta Biomembr, 1195, pp. 11-20
Trubetskoy, V.S., Torchilin, V.P., (1995) Adv. Drug Delivery Rev, 16, pp. 311-320
Liu, S., Edwards, D.S., (2001) Bioconjugate Chem, 12, pp. 7-34
Moghimi, S.M., Hunter, A.C., Murray, J.C., (2001) Pharmacol. Rev, 53, pp. 283-318
Vaccaro, M., Accardo, A., Tesauro, D., Mangiapia, G., Löf, D., Schillén, K., Söderman, O., Paduano, L., (2006) Langmuir, 22, pp. 6635-6643
Feigin, L.A., Svergun, D.I., (1987) Structure analysis by small-angle X-ray and neutron scattering, , Plenum, New York
Mangiapia, G., Accardo, A., LoCelso, F., Tesauro, D., Morelli, G., Radulescu, A., Paduano, L., (2004) J. Phys. Chem. B, 108, pp. 17611-17617
Vergara, A., Paduano, L., Vitagliano, V., Sartorio, R., (1999) Phys. Chem. Chem. Phys, 1, pp. 5377-5383
Aloj, L., Jagoda, E., Lang, L., Caraco, C., Neumann, R.D., Sung, C., Eckelman, W.C., (1999) J. Nucl. Med, 40, pp. 1547-1555
Fritze, A., Hens, F., Kimpfler, A., Schubert, R., Peschka-Süss, R., (2006) Biochim. Biophys. Acta Biomembr, 1758, pp. 1633-1640
Aloj, L., Caraco, C., Panico, M., Zannetti, A., Del Vecchio, S., Tesauro, D., De Luca, S., Salvatore, M., (2004) J. Nucl. Med, 45, pp. 485-494
Schmitt, L., Dietrich, C., (1994) J. Am. Chem. Soc, 116, pp. 8485-8491
Chang, W.C., White, P.D., (2000) Fmoc solid phase peptide synthesis, , Oxford University Press, Oxford
Kotlarchyk, A.M., Chen, S.H., (1983) J. Chem. Phys, 79, pp. 2461-2469
Schwahn, B.D., Richter, D., Lin, M., Fetters, L.J., Lewis, J., (2002) Macromolecules, 35, pp. 3762-3768
Ma, C.G., Barlow, D.J., Lawrence, M.J., Heenan, R.K., Timmins, P., (2000) J. Phys. Chem. B, 104, pp. 9081-9085
Jansson, J., Schillén, K., Olofsson, G., Cardoso da Silva, R., Loh, W.J.J., (2004) J. Phys. Chem. B, 108, pp. 82-92
Berne, B.J., Pecora, R., (2000) Dynamic Light Scattering: With Application to Chemistry, Biology and Physics, , Dover Mineola, New York
Young, R.J., Lovell, P.A., (1996) Introduction to Polymers, , Chapman & Hall, London
Stepánek, P., (1993) Dynamic Light Scattering, , Ed, W. Brown, Oxford University Press, Oxford
Johnsen, R., Brown, W., Bloomfield, (1992) Laser Light Scattering in Biochemistry, p. 77. , Eds, S. E. Harding, D. B. Sattelle, Royal Society of Chemistry, Cambridge
Glatter, O., Scherf, G., Schillén, K., Brown, W., (1994) Macromolecules, 27, pp. 6046-6054
Almgren, M., Edwards, K., Gustafsson, J.J., (1996) Curr. Opin. Colloid Interface Sci, 1, pp. 270-278
Skehan, P., Storeng, R., Scudiero, D., Monks, A., McMahon, J., Vistica, D., Warren, J.T., Boyd, M.R., (1990) J. Natl. Med. Assoc. J. Natl. Cancer Inst, 82, pp. 1107-1112
Torchilin, V. P., (2005) Nat. Rev. Drug Discovery, 4, pp. 145-160
Allen, M. T., (2002) Nat. Rev. Cancer, 2, pp. 750-763
Lobo, E. D., Hansen, R. J., Balthasar, J. P., (2004) J. Pharm. Sci, 93, pp. 2645-2668
Lamberts, S. W., Krenning, E. P., Reubi, J. C., (1991) Endocr. Rev, 12, pp. 450-482
Mulder, W. J. M., Strijkers, G. J., van Tilborg, G. A. F., Griffioen, A. W., Nicolay, K., (2006) NMR Biomed, 19, pp. 142-164
Mierke, D. F., Giragossian, C., (2001) Med. Res. Rev, 21, pp. 450-471
Reubi, J. C., Schaer, J. C., Waser, B., (1997) Cancer Res, 57, pp. 1377-1386
Torchilin, V. P., Omelyanenko, V. G., Papisov, M. I., Bogdanov, A. J., Trubetskoy, V. S., Herron, J. N., Gentry, C. A., (1994) Biochim. Biophys. Acta Biomembr, 1195, pp. 11-20
Trubetskoy, V. S., Torchilin, V. P., (1995) Adv. Drug Delivery Rev, 16, pp. 311-320
Moghimi, S. M., Hunter, A. C., Murray, J. C., (2001) Pharmacol. Rev, 53, pp. 283-318
Feigin, L. A., Svergun, D. I., (1987) Structure analysis by small-angle X-ray and neutron scattering, , Plenum, New York
Chang, W. C., White, P. D., (2000) Fmoc solid phase peptide synthesis, , Oxford University Press, Oxford
Kotlarchyk, A. M., Chen, S. H., (1983) J. Chem. Phys, 79, pp. 2461-2469
Schwahn, B. D., Richter, D., Lin, M., Fetters, L. J., Lewis, J., (2002) Macromolecules, 35, pp. 3762-3768
Ma, C. G., Barlow, D. J., Lawrence, M. J., Heenan, R. K., Timmins, P., (2000) J. Phys. Chem. B, 104, pp. 9081-9085
Jansson, J., Schill n, K., Olofsson, G., Cardoso da Silva, R., Loh, W. J. J., (2004) J. Phys. Chem. B, 108, pp. 82-92
Berne, B. J., Pecora, R., (2000) Dynamic Light Scattering: With Application to Chemistry, Biology and Physics, , Dover Mineola, New York
Young, R. J., Lovell, P. A., (1996) Introduction to Polymers, , Chapman & Hall, London
Step nek, P., (1993) Dynamic Light Scattering, , Ed, W. Brown, Oxford University Press, Oxford
New nanocarriers are obtained by assembling two amphiphilic monomers: one containing the bioactive peptide CCK8 spaced, by a polydisperse poly(ethylene glycol), from two hydrophobic tails ((C18)2PEG2000CCK8), and the other containing a chelating agent able to give stable radiolabeled indium-111 complexes linked to the same hydrophobic moiety ((C18)2DTPAGlu). The size and shape of the supramolecular aggregates were structurally characterized by dynamic light scattering, small-angle neutron scattering, and cryogenic transmission electronic microscopy. Under the experimental conditions we investigated (pH 7.4 and molar ratio between monomers 30:70), there is the presence of high polydisperse aggregates: rod-like micelles with a radius of ∼40 Å and length >700 Å, open bilayer fragments with thickness ∼65 Å, and probably vesicles. The presence of the bioactive peptide well exposed on the external surface of the aggregate allows selective targeting of nanocarriers towards the cholecystokinin receptors overexpressed by the cancerous cells. In vitro binding assays and in vivo biodistribution studies by nuclear medicine experiments using indium-111 are reported. Moreover, preliminary data concerning the drug loading capability of the aggregates and their drug efficiency on the target cells is reported by using the cytotoxic drug doxorubicin. Incubation of receptor-positive and control cells with peptide-containing aggregates filled with doxorubicin shows significantly lower cell survival in receptor-expressing cells relative to the control, for samples incubated in the presence of doxorubicin. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
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Capasso D, De Paola I, Liguoro A, Del Gatto A, Di Gaetano S, Guarnieri D, Saviano M, Zaccaro L
* Rgdechi-Hcit: Alpha V Beta 3 Selective Pro-Apoptotic Peptide As Potential Carrier For Drug Delivery Into Melanoma Metastatic Cells (202 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2014 Sep 23; 9(9): e106441-e106441.
Impact Factor: 3.234
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Oliveri V, Attanasio F, Puglisi A, Spencer J, Sgarlata C, Vecchio G
* Multifunctional 8-hydroxyquinoline-appended cyclodextrins as new inhibitors of metal-induced protein aggregation (249 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2014 Jul 14; 20(29): 8954-8964.
Impact Factor: 5.731
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Galdiero S, Falanga A, Vitiello M, Grieco P, Caraglia M, Morelli G, Galdiero M
* Exploitation of viral properties for intracellular delivery (200 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617linking), 2014 Jul; 20(7): 468-478.
Impact Factor: 1.546
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Accardo A, Ringhieri P, Szekely N, Pipich V, Luchini A, Paduano L, Tesauro D
* Structural insights on nanoparticles containing gadolinium complexes as potential theranostic (184 visite)
Colloid Polym Sci (ISSN: 0303-402x), 2014 May; 292(5): 1121-1127.
Impact Factor: 1.865
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Accardo A, Ringhieri P, Palumbo R, Morelli G
* Influence of PEG length on conformational and binding properties of CCK peptides exposed by supramolecular aggregates (200 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2014 Apr; 101(4): 304-312.
Impact Factor: 2.385
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Accardo A, Aloj L, Aurilio M, Morelli G, Tesauro D
* Receptor binding peptides for target-selective delivery of nanoparticles encapsulated drugs (296 visite)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1176-9114linking), 2014 Mar 27; 9(1): 1537-1557.
Impact Factor: 4.383
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Roviello GN, Roviello GN, Musumeci D, Capasso D, Di Gaetano S, Costanzo M, Pedone C
* Synthesis and supramolecular assembly of 1, 3-bis(1 '-uracilyl)-2-propanone (180 visite)
Rsc Adv (ISSN: 2046-2069), 2014; 4(54): 28691-28698.
Impact Factor: 3.84
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Alterio V, Pan P, Parkkila S, Buonanno M, Supuran CT, Monti SM, De Simone G
* The Structural Comparison Between Membrane-Associated Human Carbonic Anhydrases Provides Insights Into Drug Design Of Selective Inhibitors (162 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2014; 101(7): 769-778.
Impact Factor: 2.385
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Clemente F, Arpaia P, Manna C
* Characterization of human skin impedance after electrical treatment for transdermal drug delivery (143 visite)
Measurement (ISSN: 0263-2241), 2013 Nov; 46(9): 3494-3501.
Impact Factor: 1.526
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Pica A, Merlino A, Buell AK, Knowles TJ, Pizzo E, D'Alessio G, Sica F, Mazzarella L
* Three-dimensional domain swapping and supramolecular protein assembly: insights from the X-ray structure of a dimeric swapped variant of human pancreatic RNase (173 visite)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2013 Oct; 69: 2116-2123.
Impact Factor: 7.232
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Galdiero S, Falanga A, Cantisani M, Vitiello M, Morelli G, Galdiero M
* Peptide-Lipid Interactions: Experiments and Applications (296 visite)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067electronic), 2013 Sep; 14(9): 18758-18789.
Impact Factor: 2.339
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Nande R, Greco A, Gossman MS, Lopez JP, Claudio L, Salvatore M, Brunetti A, Denvir J, Howard CM, Claudio PP
* Microbubble-assisted p53, RB, and p130 gene transfer in combination with radiation therapy in prostate cancer (239 visite)
Current Gene Therapy (ISSN: 1875-5631, 1566-5232), 2013 Jun 1; 13(3): 163-174.
Impact Factor: 4.906
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Falciani C, Brunetti J, Lelli B, Accardo A, Tesauro D, Morelli G, Bracci L
* Nanoparticles exposing neurotensin tumor-specific drivers (212 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Apr; 19(4): 198-204.
Impact Factor: 1.862
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Accardo A, Mangiapia G, Paduano L, Morelli G, Tesauro D
* Octreotide labeled aggregates containing platinum complexes as nanovectors for drug delivery (211 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Apr; 19(4): 190-197.
Impact Factor: 1.862
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Calce E, Monfregola L, Sandomenico A, Saviano M, De Luca S
* Fluorescence study for selecting specific ligands toward HER2 receptor: An example of receptor fragment approach (196 visite)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2013 Mar; 61: 116-121.
Impact Factor: 3.432
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Travaglia A, Satriano C, Giuffrida ML, La Mendola D, Rampazzo E, Prodi L, Rizzarelli E
* Electrostatically driven interaction of silica-supported lipid bilayer nanoplatforms and a nerve growth factor-mimicking peptide (158 visite)
Soft Matter (ISSN: 1744-683x), 2013; 9(18): 4648-4654.
Impact Factor: 4.151
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Smaldone G, Falanga A, Capasso D, Guarnieri D, Correale S, Galdiero M, Netti PA, Zollo M, Galdiero S, Di Gaetano S, Pedone E
* gH625 is a viral derived peptide for effective delivery of intrinsically disordered proteins (201 visite)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1178-2013electronic), 2013; 8: 2555-2565.
Impact Factor: 4.195
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Berisio R
* Learning from pathogens: Exploiting host-pathogen liaison for therapeutic development (159 visite)
Curr Protein Pept Sci (ISSN: 1389-2037), 2012 Dec; 13(8): 697-698.
Impact Factor: 2.326
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Accardo A, Mansi R, Salzano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Ziaco B, Tesauro D, Aloj L, De Rosa G, Morelli G
* Bombesin peptide antagonist for target-selective delivery of liposomal doxorubicin on cancer cells (198 visite)
Journal Of Drug Targeting (ISSN: 1061-186x), 2012 Nov 21; 21(3): 240-249.
Impact Factor: 2.768
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Roviello GN, Roviello G, Musumeci D, Bucci EM, Pedone C
* Dakin-West reaction on 1-thyminyl acetic acid for the synthesis of 1, 3-bis(1-thyminyl)-2-propanone, a heteroaromatic compound with nucleopeptide-binding properties (177 visite)
Amino Acids (ISSN: 1438-2199, 0939-4451, 1438-2199electronic), 2012 Oct; 43(4): 1615-1623.
Impact Factor: 3.914
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Galdiero S, Vitiello M, Falanga A, Cantisani M, Incoronato N, Galdiero M
* Intracellular Delivery: Exploiting Viral Membranotropic Peptides (281 visite)
Current Drug Metabolism (ISSN: 1389-2002), 2012 Jan; 13(1): 93-104.
Impact Factor: 4.405
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Accardo A, Salsano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Tesauro D, Aloj L, De Rosa G, Morelli G
* Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells: A potential theranostic agent (184 visite)
Int J Nanomed (ISSN: 1176-9114, 1178-2013, 1178-2013electronic), 2012; 7: 2007-2017.
Impact Factor: 3.463
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Falanga A, Vitiello MT, Cantisani M, Tarallo R, Guarnieri D, Mignogna E, Netti P, Pedone C, Galdiero M, Galdiero S
* A peptide derived from herpes simplex virus type 1 glycoprotein H: membrane translocation and applications to the delivery of quantum dots (157 visite)
Nanomedicine (ISSN: 1549-9642, 1549-9634, 1549-9642electronic), 2011 Dec; 7(6): 925-934.
Impact Factor: 6.692
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Tarallo R, Accardo A, Falanga A, Guarnieri D, Vitiello G, Netti P, D'Errico G, Morelli G, Galdiero S
* Clickable functionalization of liposomes with the gH625 peptide from herpes simplex virus type i for intracellular drug delivery (194 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Nov 4; 17(45): 12659-12668.
Impact Factor: 5.925
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Ocak M, Helbok A, Rangger C, Peitl PK, Nock BA, Morelli G, Eek A, Sosabowskijk, Breeman WA, Reubi JC, Decristoforo C
* Comparison of biological stability and metabolism of CCK2 receptor targeting peptides, a collaborative project under COST BM0607 (259 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2011 Sep; 38(8): 1426-1435.
Impact Factor: 4.991
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Tornesello AL, Aurilio M, Accardo A, Tarallo L, Barbieri A, Arra C, Tesauro D, Morelli G, Aloj L
* Gastrin and cholecystokinin peptide-based radiopharmaceuticals: An in vivo and in vitro comparison (191 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 May; 17(5): 405-412.
Impact Factor: 1.799
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Falciani C, Accardo A, Brunetti J, Tesauro D, Lelli B, Pini A, Bracci L, Morelli G
* Target-Selective Drug Delivery through Liposomes Labeled with Oligobranched Neurotensin Peptides (243 visite)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2011 Apr 4; 6(4): 678-685.
Impact Factor: 3.151
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Accardo A, Morisco A, Palladino P, Palumbo R, Tesauro D, Morelli G
* Amphiphilic CCK peptides assembled in supramolecular aggregates: Structural investigations and in vitro studies (238 visite)
Mol Biosyst (ISSN: 1742-206x), 2011 Mar; 7(3): 862-870.
Impact Factor: 3.534
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Accardo A, Morisco A, Gianolio E, Tesauro D, Mangiapia G, Radulescu A, Brandt A, Morelli G
* Nanoparticles containing octreotide peptides and gadolinium complexes for MRI applications (244 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 Feb; 17(2): 154-162.
Impact Factor: 1.799
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Accardo A, Morisco A, Tesauro D, Pedone C, Morelli G
* Naposomes: A new class of peptide-derivatized, target-selective multimodal nanoparticles for imaging and therapeutic applications (224 visite)
Ther Deliv (ISSN: 2041-5990), 2011 Feb; 2(2): 235-257.
Impact Factor: 0
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Morisco A, Accardo A, Tesauro D, Palumbo R, Benedetti E, Morelli G
* Peptide-labeled supramolecular aggregates as selective doxorubicin carriers for delivery to tumor cells (169 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2011; 96(1): 88-96.
Impact Factor: 2.87
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Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment: Challenges and perspectives (302 visite)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 249-258.
Impact Factor: 1.724
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Moccia M, Musumeci D, Roviello GN, Fusco S, Valente M, Bucci EM, Sapio R, Pedonea C, Netti PA
* Preliminary studies on noncovalent hyperbranched polymers based on PNA and DNA building blocks (262 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Oct; 15(10): 647-653.
Impact Factor: 1.807
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Accardo A, Tesauro D, Aloj L, Pedone C, Morelli G
* Supramolecular aggregates containing lipophilic Gd(III) complexes as contrast agents in MRI (142 visite)
Coord Chem Rev (ISSN: 0010-8545), 2009 Sep; 253(17-18): 2193-2213.
Impact Factor: 11.225
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Accardo A, Tesauro D, Morisco A, Mangiapia G, Vaccaro M, Gianolio E, Heenan RK, Paduano L, Morelli G
* Micelles obtained by aggregation of gemini surfactants containing the CCK8 peptide and a gadolinium complex (213 visite)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257linking), 2009 May; 14(4): 587-599.
Impact Factor: 3.415
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Zaccaro L, Del Gatto A, Pedone C, Saviano M
* Peptides for tumour therapy and diagnosis: current status and future directions (272 visite)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2009 Mar; 16(7): 780-795.
Impact Factor: 4.708
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Vaccaro M, Mangiapia G, Radulescu A, Schillen K, D'Errico G, Morelli G, Paduano L
* Colloidal particles composed of amphiphilic molecules binding gadolinium complexes and peptides as tumor-specific contrast agents in MRI: physico-chemical characterization (293 visite)
Soft Matter (ISSN: 1744-683x), 2009; 5(13): 2504-2512.
Impact Factor: 4.869
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Accardo A, Tesauro D, Morelli G, Del Pozzo L, Pedone C, Tornesello AL, Benedetti E
* Supramolecular aggregates derivatized by CCK8 peptide as selective nanocarriers for drug delivery (119 visite)
Adv Exp Med Biol (ISSN: 0065-2598, 0065-2598print), 2009; 611: 603-604.
Impact Factor: 2.02
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Vaccaro M, Mangiapia G, Accardo A, Tesauro D, Gianolio E, Frielinghaus H, Morelli G, Paduano L
* Polymerized mixed aggregates containing gadolinium complex and CCK8 peptide (170 visite)
Colloid Polym Sci (ISSN: 0303-402x), 2008 Dec; 286(14-15): 1643-1652.
Impact Factor: 1.736
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Marasco D, Perretta G, Sabatella M, Ruvo M
* Past and Future Perspectives of Synthetic Peptide Libraries (183 visite)
Curr Protein Pept Sci (ISSN: 1389-2037), 2008 Oct; 9(5): 447-467.
Impact Factor: 3.011
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Accardo A, Tesauro D, Del Pozzo L, Mangiapia G, Paduano L, Morelli G
* Micelles by self-assembling peptide-conjugate amphiphile: Synthesis and structural characterization (210 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): 903-910.
Impact Factor: 1.654
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Accardo A, Tesauro D, Benedetti E, Pedone C, Morelli G
* Naposomes: A new class of peptide containing supramolecular aggregates as target selective delivery systems (121 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
Impact Factor: 1.654
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Saviano M, De Luca S, Morelli G, Tesauro D, Pedone C
* Preparation and use of cyclic and branched peptides and their labelled derivatives as therapeutic agents, cholecystokinin agonists or antagonists, and diagnostic agents to identify and locate tumours (200 visite)
Patents Official Gazette Of The United States Patent And Trademark Office (ISSN: 0098-1133), 2008 Feb 12; N/D: N/D-N/D.
Impact Factor: 0
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Zeni O, Palumbo R, Bernini R, Zeni L, Sarti M, Scarfi MR
* Cytotoxicity investigation on cultured human blood cells treated with single-wall carbon nanotubes (153 visite)
Sensors (ISSN: 1424-3210, 1424-8220, 1424-8220electronic), 2008 Jan; 8(1): 488-499.
Impact Factor: 1.87
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D'Andrea LD, Testa I, Panico M, Di Stasi R, Carac C, Tarallo L, Arra C, Barbieri A, Romanelli A, Aloj L
* In vivo and in vitro characterization of CCK8 bearing a histidine-based chelator labeled with Tc-99m-tricarbonyl (214 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2008; 90(5): 707-712.
Impact Factor: 2.823
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De Luca S, De Capua A, Saviano M, Della Moglie R, Aloj L, Tarallo L, Pedone C, Morelli G
* Synthesis and biological evaluation of cyclic and branched peptide analogues as ligands for cholecystokinin type 1 receptor (180 visite)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2007 Sep 1; 15(17): 5845-5853.
Impact Factor: 2.662
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Vaccaro M, Accardo A, D'Errico G, Schillen K, Radulescu A, Tesauro D, Morelli G, Paduano L
* Peptides and gd complexes containing colloidal assemblies as tumor-specific contrast agents in MRI: Physicochemical characterization (189 visite)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2007 Sep; 93(5): 1736-1746.
Impact Factor: 4.627
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Maggi A, Salvatore M
Molecular imaging (185 visite)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 95-95.
Impact Factor: 1.724
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Del Vecchio S, Zannetti A, Fonti R, Pace L, Salvatore M
* Nuclear imaging in cancer theranostics (320 visite)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 152-163.
Impact Factor: 1.724
Dettagli Esporta in BibTeX Esporta in EndNote
Tesauro D, Accardo A, Gianolio E, Paduano L, Teixeira J, Schillén K, Aime S, Morelli G
* Peptide derivatized lamellar aggregates as target-specific MRI contrast agents (210 visite)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 25; 8(8): 950-955.
Impact Factor: 3.446
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Agostini S, Bolzati C, Didonè E, Cavazza-Ceccato M, Refosco F, Aloj L, Arra C, Aurilio M, Tornesello AL, Tesauro D, Morelli G
* The (Tc(N)(PNP))2+ metal fragment labeled cholecystokinin-8 (CCK8) peptide for CCK-2 receptors imaging: In vitro and in vivo studies (200 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2007 Apr; 13(4): 211-219.
Impact Factor: 1.768
Dettagli Esporta in BibTeX Esporta in EndNote
Accardo A, Tesauro D, Morelli G, Gianolio E, Aime S, Vaccaro M, Mangiapia G, Paduano L, Schillén K
* High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI (194 visite)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2007 Feb; 12(2): 267-276.
Impact Factor: 3.325
Dettagli Esporta in BibTeX Esporta in EndNote
Accardo A, Tesauro D, Mangiapia G, Pedone C, Morelli G
* Nanostructures by self-assembling peptide amphiphile as potential selective drug carriers (207 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2007; 88(2): 115-121.
Impact Factor: 2.389
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Aloj L, Aurilio M, Rinaldi V, D'Ambrosio L, Tesauro D, Peitl PK, Maina T, Mansi R, Von Guggenberg E, Joosten L, Sosabowski JK, Breeman WA, De Blois E, Koelewijn S, Melis M, Waser B, Beetschen K, Reubi JC, De Jong M
* The EEE project (223 visite)
Proc Int Cosm Ray Conf Icrc Universidad Nacional Autonoma De Mexico, 2007; 5(HEPART2): 977-980.
Impact Factor: 0
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De Luca S, Saviano M, Della Moglie R, Digilio G, Bracco C, Aloj L, Tarallo L, Pedone C, Morelli G
* Conformationally constrained CCK8 analogues obtained from a rationally designed peptide library as ligands for cholecystokinin type B receptor (178 visite)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2006 Sep; 1(9): 997-1006.
Impact Factor: 3.046
Dettagli Esporta in BibTeX Esporta in EndNote
Vaccaro M, Accardo A, Tesauro D, Mangiapia G, Loef D, Schillen K, Soederman O, Morelli G, Paduan L
* Supramolecular aggregates of amphiphilic gadolinium complexes as blood pool MRI/MRA contrast agents: Physicochemical characterization (179 visite)
Langmuir (ISSN: 0743-7463), 2006 Jul 18; 22(15): 6635-6643.
Impact Factor: 3.902
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De Luca S, Saviano M, Lassiani L, Yannakopoulou K, Stefanidou P, Aloj L, Morelli G, Varnavas A
* Anthranilic acid based CCK1 receptor antagonists and CCK-8 have a common step in their "receptor desmodynamic processes" (175 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Apr 20; 49(8): 2456-2462.
Impact Factor: 5.115
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Pappalardo M, Milardi D, Grasso D, La Rosa C
* Phase behaviour of polymer-grafted DPPC membranes for drug delivery systems design (129 visite)
Journal Of Thermal Analysis And Calorimetry (ISSN: 1388-6150), 2005 May; 80(2): 413-418.
Impact Factor: 1.425
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De Luca S, Sanseverino M, Zocchi I, Pedone C, Morelli G, Ragone R
* Receptor fragment approach to the binding between CCK8 peptide and cholecystokinin receptors: A fluorescence study on type B receptor fragment CCKB-R (352-379) (165 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2005 Mar; 77(4): 205-211.
Impact Factor: 2.545
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De Luca S, Morelli G
* Synthesis and characterization of a sulfated and a non-sulfated cyclic CCK8 analogue functionalized with a chelating group for metal labelling (169 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2004 May; 10(5): 265-273.
Impact Factor: 1.652
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Accardo A, Tesauro D, Roscigno P, Gianolio E, Paduano L, D'Errico G, Pedone C, Morelli G
* Physicochemical Properties of Mixed Micellar Aggregates Containing CCK Peptides and Gd Complexes Designed as Tumor Specific Contrast Agents in MRI (199 visite)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2004 Mar 17; 126(10): 3097-3107.
Impact Factor: 6.903
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Aloj L, Caracò C, Panico M, Zannetti A, Del Vecchio S, Tesauro D, De Luca S, Arra C, Pedone C, Morelli G, Salvatore M
* In vitro and in vivo evaluation of In-111-DTPAGlu-G-CCK8 for cholecystokinin-B receptor imaging (278 visite)
J Nucl Med (ISSN: 1535-5667, 0161-5505, 1535-5667electronic), 2004 Mar; 45(3): 485-494.
Impact Factor: 5.362
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Aloj L, Panico M, Caraco C, Del Vecchio S, Arra C, Affuso A, Accardo A, Mansi R, Tesauro D, De Luca S, Pedone C, Visentin R, Mazzi U, Morelli G, Salvatore M
* In vitro and in vivo characterization of Indium-111 and Technetium-99m labeled CCK-8 derivatives for CCK-B receptor imaging (220 visite)
Cancer Biotherapy And Radiopharmaceuticals (ISSN: 1084-9785, 1084-4978), 2004 Feb; 19(1): 93-98.
Impact Factor: 1.091
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Cortesi R, Mischiati C, Borgatti M, Breda L, Romanelli A, Saviano M, Pedone C, Gambari R, Nastruzzi C
* Formulations for natural and peptide nucleic acids based on cationic polymeric submicron particles (191 visite)
The Aaps Journal (ISSN: 1522-1059, 1550-7416), 2004 Jan 20; 6(1): N/D-N/D.
Impact Factor: 1.938
Dettagli Esporta in BibTeX Esporta in EndNote
De Luca S, Ragone R, Bracco C, Digilio G, Aloj L, Tesauro D, Saviano M, Pedone C, Morelli G
* A cyclic CCK8 analogue selective for the cholecystokinin type A receptor: design, synthesis, NMR structure and binding measurements (199 visite)
Chembiochem (ISSN: 1439-7633, 1439-4227, 1439-7633electronic), 2003 Nov 7; 4(11): 1176-1187.
Impact Factor: 3.992
Dettagli Esporta in BibTeX Esporta in EndNote
De Luca S, Ragone R, Bracco C, Digilio G, Tesauro D, Saviano M, Pedone C, Morelli G
* The role of segment 32-47 of cholecystokinin receptor type A in CCK8 binding: Synthesis, nuclear magnetic resonance, circular dichroism and fluorescence studies (143 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2003 Mar; 9(3): 156-169.
Impact Factor: 1.377
Dettagli Esporta in BibTeX Esporta in EndNote
Borgatti M, Breda L, Cortesi R, Nastruzzi C, Romanelli A, Saviano M, Bianchi N, Mischiati C, Pedone C, Gambari R
* Cationic Liposomes As Delivery Systems For Double-Stranded Pna-Dna Chimeras Exhibiting Decoy Activity Against Nf-Kappab Transcription Factors (134 visite)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 1873-2968, 0006-2952), 2002 Sep 15; 64(4): 609-616.
Impact Factor: 3.542
Dettagli Esporta in BibTeX Esporta in EndNote
Morelli G, De Luca S, Tesauro D, Saviano M, Pedone C, Dolmella A, Visentin R, Mazzi U
* CCK8 peptide derivatized with diphenylphosphine for rhenium labelling: Synthesis and molecular mechanics calculations (132 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2002 Jul; 8(7): 373-381.
Impact Factor: 1.691
Dettagli Esporta in BibTeX Esporta in EndNote
Aloj L, Panico M, Caracó C, Zannetti A, Del Vecchio S, Di Nuzzo C, Arra C, Morelli G, Tesauro D, De Luca S, Pedone C, Salvatore M
* Radiolabeling approaches for cholecystokinin B receptor imaging (245 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2002; 66(6): 370-380.
Impact Factor: 2.372
Dettagli Esporta in BibTeX Esporta in EndNote
Aloj L, Zannetti A, Caraco C, Del Vecchio S, Tasauro D, De Luca S, Brunetti A, Aime S, Morelli G, Pedone C
* Characterization of 111In labeled CCK8 peptide coupled to a novel DTPA-like derivative in CCK-B receptor overexpressing cells (219 visite)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2001 Sep; 28(8): N/D-N/D.
Impact Factor: 3.464
Dettagli Esporta in BibTeX Esporta in EndNote
De Luca S, Tesauro D, Di Lello P, Fattorusso R, Saviano M, Pedone C, Morelli G
* Synthesis and solution characterization of a porphyrin-CCK8 conjugate (175 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2001 Jul; 7(7): 386-394.
Impact Factor: 1.451
Dettagli Esporta in BibTeX Esporta in EndNote
Ragone R, De Luca S, Tesauro D, Pedone C, Morelli G
Fluorescence studies on the binding between 1-47 fragment of cholecystokinin receptor CCKA-R(1-47) and nonsulfated cholecystokinin octapeptide CCK8 (191 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2000; 56(1): 47-53.
Impact Factor: 2.405
Dettagli Esporta in BibTeX Esporta in EndNote
89 Records (84 escludendo Abstract e Conferenze).
Impact factor totale: 278.979 (266.965 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 303.485 (286.351 escludendo Abstract e Conferenze).
Impact factor totale: 278.979 (266.965 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 303.485 (286.351 escludendo Abstract e Conferenze).
Esporta in BibTeX Esporta in EndNote
Ultima modifica di Marco Comerci in data Thursday 19 March 2015, 14:45:53
183 visite. Ultima visita in data Sunday 08 December 2019, 15:40:41
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