Synthesis And Antioxidant Activity Of New Homocarnosine Beta-Cyclodextrin Conjugates (228 visite)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2007 Jul; 42(7): 910-920.
Tipo di articolo: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 2.301, Impact factor a 5 anni: 2.548
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-34250160541&partnerID=40&md5=a65d0b29e2713290019cc8a607581f9a
Parole chiave: β-Cylodextrin, Carnosine, Homocarnosine, Low Density Lipoprotein, Pulse Radiolysis, 3a [[4 [[1 Carboxy 2 (1h Imidazol 4 Yl)ethyl]amino] 4 Oxobutyl]amino] 3a Deoxy Beta Cyclodextrin, 6a [[4 [[1 Carboxy 2 (1h Imidazol 4 Yl)ethyl]amino] 4 Oxobutyl]amino] 6a Deoxy Beta Cyclodextrin, Cupric Ion, Reactive Oxygen Metabolite, Scavenger, Unclassified Drug, Antioxidant Activity, Article, Controlled Study, Drug Activity, Drug Structure, Drug Synthesis, Human, In Vitro Study, In Vivo Study, Nuclear Magnetic Resonance, Oxidation, Beta-Cyclodextrins, Hydrogen-Ion Concentration, Magnetic Resonance Spectroscopy, Molecular Structure, Oxidation-Reduction, 3a [[4 [[1 Carboxy 2 (1h Imidazol 4 Yl) Ethyl] Amino] 4 Oxobutyl] Amino] 3a Deoxy Beta Cyclodextrin, 6a [[4 [[1 Carboxy 2 (1h Imidazol 4 Yl) Ethyl] Amino] 4 Oxobutyl] Amino] 6a Deoxy Beta Cyclodextrin,
Affiliazioni:
*** IBB - CNR ***
Dipartimento di Scienze Chimiche, Università di Catania, V.le A. Doria 6, 95125 Catania, Italy
Istituto di Biochimica, Biochimica Clinica, Università Cattolica Sacro Cuore, Largo F. Vito 1, 00164 Roma, Italy
Istituto di Biostrutture e Bioimmagini, CNR, Catania, V.le A. Doria 6, 95125 Catania, Italy
Riferimenti:
Szejtli, J., (1998) Chem. Rev., 98, pp. 1743-175
Pralhad, T., Rajendrakumar, K., (2004) J. Pharm. Biomed. Anal., 34, pp. 333-339
Uekama, K., (2004) Chem. Pharm. Bull., 52, pp. 900-915
Di Blasio, B., Pavone, V., Nastri, F., Isernia, C., Saviano, M., Pedone, C., Cucinotta, V., Vecchio, G., (1992) Proc. Natl. Acad. Sci. USA, 89, pp. 7218-7221
Djedaini-Pilard, F., Desalos, J., Perly, B., (1993) Tetrahedron Lett., 34, pp. 2457-2460
Fernandez, M., Fragoso, A., Cao, R., Banos, M., Ansorge-Schumacher, M., Hartmeier, W., Villalonga, R., (2004) J. Mol. Catal. B Enzym., 31, pp. 47-52
Hristova-Kazmierski, M.K., Horan, P., Davis, P., Yamamura, H.I., Kramer, T., Horvath, R., Kazmierski, W.M., Hruby, V.J., (1993) Bioorg. Med. Chem. Lett., 3, pp. 831-834
Parrot-Lopez, H., Djedaini, F., Perly, B., Coleman, A.W., Galons, H., Miocque, M., (1990) Tetrahedron Lett., 31, pp. 1999-2002
Pean, C., Creminon, C., Wijkhuisen, A., Grassi, J., Guenot, P., Jehan, P., Dalbiez, J.-P., Djedaini-Pilard, F., (2000) J. Chem. Soc. Perkin Trans., 2, pp. 853-863
Schaschke, N., Fiori, S., Weyher, E., Escrieut, C., Fourmy, D., Mueller, G., Moroder, L., (1998) J. Am. Chem. Soc., 120, pp. 7030-7038
Boldyrev, A.A., Johnson, P., (2002) Oxidative Stress at Molecular, Cellular and Organ Levels, pp. 101-113. , Boldyrev A.A., and Johnson P. (Eds), Research Signpost, India
Skulachev, V.P., (2000) Biochemistry (Mosc), 65, pp. 749-750
Tabakman, R., Lazarovici, P., Kohen, R., (2002) J. Neurosci. Res., 68, pp. 463-469
Mzhelskaya, T.I., Boldyrev, A.A., (1999) Neirokhimiya, 16, pp. 133-144
Petroff, O.A., Hyder, F., Mattson, R.H., Rothman, D.L., (1999) Neurology, 52, pp. 473-478
Guiotto, A., Calderan, A., Ruzza, P., Borin, G., (2005) Curr. Med. Chem., 12, pp. 2293-2315
Teufel, M., Saudek, V., Ledig, J.-P., Bernhardt, A., Boularand, S., Carreau, A., Cairns, N.J., Smirnova, T., (2003) J. Biol. Chem., 278, pp. 6521-6531
Bonomo, R.P., Bruno, V., Conte, E., De Guidi, G., La Mendola, D., Maccarrone, G., Nicoletti, F., Vecchio, G., (2003) J. Chem. Soc. Dalton Trans., pp. 4406-4415
La Mendola, D., Sortino, S., Vecchio, G., Rizzarelli, E., (2002) Helv. Chim. Acta, 85, pp. 1633-1643
Bonomo, R.P., Cucinotta, V., D'Alessandro, F., Impellizzeri, G., Maccarrone, G., Vecchio, G., Rizzarelli, E., (1991) Inorg. Chem., 30, pp. 2708-2713
Teranishi, K., Watanabe, K., Hisamatsu, M., Yamada, T., (1998) J. Carbohydr. Chem., 17, pp. 489-494
Mulazzani, Q.G., D'Angelantonio, M., Venturi, M., Hoffman, M.Z., Rodgers, M.A.J., (1986) J. Phys. Chem., 90, pp. 5347-5352
Lazzarino, G., Di Pierro, D., Tavazzi, B., Cerroni, L., Giardina, B., (1991) Anal. Biochem., 197, pp. 191-196
Donze, C., Rizzarelli, E., Vecchio, G., (1998) Supramol. Chem., 10, pp. 33-42
Vecchio, G., La Mendola, D., Rizzarelli, E., (2001) J. Supramol. Chem., 1, pp. 87-95
Di Blasio, B., Galdiero, S., Saviano, M., Pedone, C., Benedetti, E., Rizzarelli, E., Pedotti, S., Gibbons, W.A., (1996) Carbohydr. Res., 282, pp. 41-52
Bonomo, R.P., Maccarrone, G., Rizzarelli, E., Vecchio, G., (2002) Inorg. Chim. Acta, 339, pp. 455-460
Cucinotta, V., Giuffrida, A., La Mendola, D., Maccarrone, G., Puglisi, A., Rizzarelli, E., Vecchio, G., (2004) J. Chromatogr. B Anal. Technol. Biomed. Life Sci., 800, pp. 127-133
Nogami, Y., Nasu, K., Koga, T., Ohta, K., Fujita, K., Immel, S., Lindner, H.J., Lichtenthaler, F.W., (1997) Angew. Chem. Int. Ed. Engl., 36, pp. 1899-1902
Chen, W.-H., Yuan, D.-Q., Fujita, K., (1996) Tetrahedron Lett., 37, pp. 7561-7564
Fujita, K., Chen, W.-H., Yuan, D.-Q., Nogami, Y., Koga, T., Fujioka, T., Mihashi, K., Lichtenthaler, F.W., (1999) Tetrahedron: Asymmetry, 10, pp. 1689-1696
Fujita, K., Ohta, K., Ikegami, Y., Shimada, H., Tahara, T., Nogami, Y., Koga, T., Nakajima, T., (1994) Tetrahedron Lett., 35, pp. 9577-9580
Buxton, G.V., Greenstock, C.L., Helman, W.P., Ross, A.B., (1988) J. Phys. Chem. Ref. Data, 17, pp. 513-886
Tamba, M., Torreggiani, A., (1998) Int. J. Radiat. Biol., 74, pp. 333-340
Bansal, K.M., Sellers, R.M., (1975) J. Phys. Chem., 79, pp. 1775-1780
Tsimikas, S., (2006) Curr. Atheroscler. Rep., 8, pp. 55-61
Patel, R.P., Darley-Usmar, V.M., (1999) Free Radic. Res., 30, pp. 1-9
Kuzuya, M., Yamada, K., Hayashi, T., Funaki, C., Naito, M., Asai, K., Kuzuya, F., (1992) Biochim. Biophys. Acta, 1123, pp. 334-341
Decker, E.A., Ivanov, V., Zhu, B.Z., Frei, B., (2001) J. Agric. Food Chem., 49, pp. 511-516
Sovago, I., Farkas, E., Bertalan, C., Lebkiri, A., Kowalik-Jankowska, T., Kozlowski, H., (1993) J. Inorg. Biochem., 51, pp. 715-726
Kritharides, L., Kus, M., Brown, A.J., Jessup, W., Dean, R.T., (1996) J. Biol. Chem., 271, pp. 27450-27455
Giessauf, A., Steiner, E., Esterbauer, H., (1995) Biochim. Biophys. Acta, 1256, pp. 221-232
Aachmann, F.L., Otzen, D.E., Larsen, K.L., Wimmer, R., (2003) Protein Eng., 16, pp. 905-912
Song, L.X., Teng, C.F., Yang, Y., (2006) J. Incl. Phenom. Macr. Chem., 54, pp. 221-232
Yi, Z., Qasim, M.A., Qasim, S., Warrington, T.L., Laskowski Jr., M., (2006) Biochim. Biophys. Acta, 1760, pp. 372-379
Boldyrev, A., Bulygina, E., Leinsoo, T., Petrushanko, I., Tsubone, S., Abe, H., (2004) Comp. Biochem. Physiol. Biochem. Mol. Biol., 137, pp. 81-88
Boldyrev, A. A., Johnson, P., (2002) Oxidative Stress at Molecular, Cellular and Organ Levels, pp. 101-113. , Boldyrev A. A., and Johnson P. (Eds), Research Signpost, India
Skulachev, V. P., (2000) Biochemistry (Mosc), 65, pp. 749-750
Mzhelskaya, T. I., Boldyrev, A. A., (1999) Neirokhimiya, 16, pp. 133-144
Petroff, O. A., Hyder, F., Mattson, R. H., Rothman, D. L., (1999) Neurology, 52, pp. 473-478
Bonomo, R. P., Bruno, V., Conte, E., De Guidi, G., La Mendola, D., Maccarrone, G., Nicoletti, F., Vecchio, G., (2003) J. Chem. Soc. Dalton Trans., pp. 4406-4415
Bonomo, R. P., Cucinotta, V., D'Alessandro, F., Impellizzeri, G., Maccarrone, G., Vecchio, G., Rizzarelli, E., (1991) Inorg. Chem., 30, pp. 2708-2713
Mulazzani, Q. G., D'Angelantonio, M., Venturi, M., Hoffman, M. Z., Rodgers, M. A. J., (1986) J. Phys. Chem., 90, pp. 5347-5352
Bonomo, R. P., Maccarrone, G., Rizzarelli, E., Vecchio, G., (2002) Inorg. Chim. Acta, 339, pp. 455-460
Chen, W. -H., Yuan, D. -Q., Fujita, K., (1996) Tetrahedron Lett., 37, pp. 7561-7564
Buxton, G. V., Greenstock, C. L., Helman, W. P., Ross, A. B., (1988) J. Phys. Chem. Ref. Data, 17, pp. 513-886
Bansal, K. M., Sellers, R. M., (1975) J. Phys. Chem., 79, pp. 1775-1780
Patel, R. P., Darley-Usmar, V. M., (1999) Free Radic. Res., 30, pp. 1-9
Decker, E. A., Ivanov, V., Zhu, B. Z., Frei, B., (2001) J. Agric. Food Chem., 49, pp. 511-516
Aachmann, F. L., Otzen, D. E., Larsen, K. L., Wimmer, R., (2003) Protein Eng., 16, pp. 905-912
Song, L. X., Teng, C. F., Yang, Y., (2006) J. Incl. Phenom. Macr. Chem., 54, pp. 221-232
Yi, Z., Qasim, M. A., Qasim, S., Warrington, T. L., Laskowski Jr., M., (2006) Biochim. Biophys. Acta, 1760, pp. 372-379
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2007 Jul; 42(7): 910-920.
Tipo di articolo: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 2.301, Impact factor a 5 anni: 2.548
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-34250160541&partnerID=40&md5=a65d0b29e2713290019cc8a607581f9a
Parole chiave: β-Cylodextrin, Carnosine, Homocarnosine, Low Density Lipoprotein, Pulse Radiolysis, 3a [[4 [[1 Carboxy 2 (1h Imidazol 4 Yl)ethyl]amino] 4 Oxobutyl]amino] 3a Deoxy Beta Cyclodextrin, 6a [[4 [[1 Carboxy 2 (1h Imidazol 4 Yl)ethyl]amino] 4 Oxobutyl]amino] 6a Deoxy Beta Cyclodextrin, Cupric Ion, Reactive Oxygen Metabolite, Scavenger, Unclassified Drug, Antioxidant Activity, Article, Controlled Study, Drug Activity, Drug Structure, Drug Synthesis, Human, In Vitro Study, In Vivo Study, Nuclear Magnetic Resonance, Oxidation, Beta-Cyclodextrins, Hydrogen-Ion Concentration, Magnetic Resonance Spectroscopy, Molecular Structure, Oxidation-Reduction, 3a [[4 [[1 Carboxy 2 (1h Imidazol 4 Yl) Ethyl] Amino] 4 Oxobutyl] Amino] 3a Deoxy Beta Cyclodextrin, 6a [[4 [[1 Carboxy 2 (1h Imidazol 4 Yl) Ethyl] Amino] 4 Oxobutyl] Amino] 6a Deoxy Beta Cyclodextrin,
Affiliazioni:
*** IBB - CNR ***
Dipartimento di Scienze Chimiche, Università di Catania, V.le A. Doria 6, 95125 Catania, Italy
Istituto di Biochimica, Biochimica Clinica, Università Cattolica Sacro Cuore, Largo F. Vito 1, 00164 Roma, Italy
Istituto di Biostrutture e Bioimmagini, CNR, Catania, V.le A. Doria 6, 95125 Catania, Italy
Riferimenti:
Szejtli, J., (1998) Chem. Rev., 98, pp. 1743-175
Pralhad, T., Rajendrakumar, K., (2004) J. Pharm. Biomed. Anal., 34, pp. 333-339
Uekama, K., (2004) Chem. Pharm. Bull., 52, pp. 900-915
Di Blasio, B., Pavone, V., Nastri, F., Isernia, C., Saviano, M., Pedone, C., Cucinotta, V., Vecchio, G., (1992) Proc. Natl. Acad. Sci. USA, 89, pp. 7218-7221
Djedaini-Pilard, F., Desalos, J., Perly, B., (1993) Tetrahedron Lett., 34, pp. 2457-2460
Fernandez, M., Fragoso, A., Cao, R., Banos, M., Ansorge-Schumacher, M., Hartmeier, W., Villalonga, R., (2004) J. Mol. Catal. B Enzym., 31, pp. 47-52
Hristova-Kazmierski, M.K., Horan, P., Davis, P., Yamamura, H.I., Kramer, T., Horvath, R., Kazmierski, W.M., Hruby, V.J., (1993) Bioorg. Med. Chem. Lett., 3, pp. 831-834
Parrot-Lopez, H., Djedaini, F., Perly, B., Coleman, A.W., Galons, H., Miocque, M., (1990) Tetrahedron Lett., 31, pp. 1999-2002
Pean, C., Creminon, C., Wijkhuisen, A., Grassi, J., Guenot, P., Jehan, P., Dalbiez, J.-P., Djedaini-Pilard, F., (2000) J. Chem. Soc. Perkin Trans., 2, pp. 853-863
Schaschke, N., Fiori, S., Weyher, E., Escrieut, C., Fourmy, D., Mueller, G., Moroder, L., (1998) J. Am. Chem. Soc., 120, pp. 7030-7038
Boldyrev, A.A., Johnson, P., (2002) Oxidative Stress at Molecular, Cellular and Organ Levels, pp. 101-113. , Boldyrev A.A., and Johnson P. (Eds), Research Signpost, India
Skulachev, V.P., (2000) Biochemistry (Mosc), 65, pp. 749-750
Tabakman, R., Lazarovici, P., Kohen, R., (2002) J. Neurosci. Res., 68, pp. 463-469
Mzhelskaya, T.I., Boldyrev, A.A., (1999) Neirokhimiya, 16, pp. 133-144
Petroff, O.A., Hyder, F., Mattson, R.H., Rothman, D.L., (1999) Neurology, 52, pp. 473-478
Guiotto, A., Calderan, A., Ruzza, P., Borin, G., (2005) Curr. Med. Chem., 12, pp. 2293-2315
Teufel, M., Saudek, V., Ledig, J.-P., Bernhardt, A., Boularand, S., Carreau, A., Cairns, N.J., Smirnova, T., (2003) J. Biol. Chem., 278, pp. 6521-6531
Bonomo, R.P., Bruno, V., Conte, E., De Guidi, G., La Mendola, D., Maccarrone, G., Nicoletti, F., Vecchio, G., (2003) J. Chem. Soc. Dalton Trans., pp. 4406-4415
La Mendola, D., Sortino, S., Vecchio, G., Rizzarelli, E., (2002) Helv. Chim. Acta, 85, pp. 1633-1643
Bonomo, R.P., Cucinotta, V., D'Alessandro, F., Impellizzeri, G., Maccarrone, G., Vecchio, G., Rizzarelli, E., (1991) Inorg. Chem., 30, pp. 2708-2713
Teranishi, K., Watanabe, K., Hisamatsu, M., Yamada, T., (1998) J. Carbohydr. Chem., 17, pp. 489-494
Mulazzani, Q.G., D'Angelantonio, M., Venturi, M., Hoffman, M.Z., Rodgers, M.A.J., (1986) J. Phys. Chem., 90, pp. 5347-5352
Lazzarino, G., Di Pierro, D., Tavazzi, B., Cerroni, L., Giardina, B., (1991) Anal. Biochem., 197, pp. 191-196
Donze, C., Rizzarelli, E., Vecchio, G., (1998) Supramol. Chem., 10, pp. 33-42
Vecchio, G., La Mendola, D., Rizzarelli, E., (2001) J. Supramol. Chem., 1, pp. 87-95
Di Blasio, B., Galdiero, S., Saviano, M., Pedone, C., Benedetti, E., Rizzarelli, E., Pedotti, S., Gibbons, W.A., (1996) Carbohydr. Res., 282, pp. 41-52
Bonomo, R.P., Maccarrone, G., Rizzarelli, E., Vecchio, G., (2002) Inorg. Chim. Acta, 339, pp. 455-460
Cucinotta, V., Giuffrida, A., La Mendola, D., Maccarrone, G., Puglisi, A., Rizzarelli, E., Vecchio, G., (2004) J. Chromatogr. B Anal. Technol. Biomed. Life Sci., 800, pp. 127-133
Nogami, Y., Nasu, K., Koga, T., Ohta, K., Fujita, K., Immel, S., Lindner, H.J., Lichtenthaler, F.W., (1997) Angew. Chem. Int. Ed. Engl., 36, pp. 1899-1902
Chen, W.-H., Yuan, D.-Q., Fujita, K., (1996) Tetrahedron Lett., 37, pp. 7561-7564
Fujita, K., Chen, W.-H., Yuan, D.-Q., Nogami, Y., Koga, T., Fujioka, T., Mihashi, K., Lichtenthaler, F.W., (1999) Tetrahedron: Asymmetry, 10, pp. 1689-1696
Fujita, K., Ohta, K., Ikegami, Y., Shimada, H., Tahara, T., Nogami, Y., Koga, T., Nakajima, T., (1994) Tetrahedron Lett., 35, pp. 9577-9580
Buxton, G.V., Greenstock, C.L., Helman, W.P., Ross, A.B., (1988) J. Phys. Chem. Ref. Data, 17, pp. 513-886
Tamba, M., Torreggiani, A., (1998) Int. J. Radiat. Biol., 74, pp. 333-340
Bansal, K.M., Sellers, R.M., (1975) J. Phys. Chem., 79, pp. 1775-1780
Tsimikas, S., (2006) Curr. Atheroscler. Rep., 8, pp. 55-61
Patel, R.P., Darley-Usmar, V.M., (1999) Free Radic. Res., 30, pp. 1-9
Kuzuya, M., Yamada, K., Hayashi, T., Funaki, C., Naito, M., Asai, K., Kuzuya, F., (1992) Biochim. Biophys. Acta, 1123, pp. 334-341
Decker, E.A., Ivanov, V., Zhu, B.Z., Frei, B., (2001) J. Agric. Food Chem., 49, pp. 511-516
Sovago, I., Farkas, E., Bertalan, C., Lebkiri, A., Kowalik-Jankowska, T., Kozlowski, H., (1993) J. Inorg. Biochem., 51, pp. 715-726
Kritharides, L., Kus, M., Brown, A.J., Jessup, W., Dean, R.T., (1996) J. Biol. Chem., 271, pp. 27450-27455
Giessauf, A., Steiner, E., Esterbauer, H., (1995) Biochim. Biophys. Acta, 1256, pp. 221-232
Aachmann, F.L., Otzen, D.E., Larsen, K.L., Wimmer, R., (2003) Protein Eng., 16, pp. 905-912
Song, L.X., Teng, C.F., Yang, Y., (2006) J. Incl. Phenom. Macr. Chem., 54, pp. 221-232
Yi, Z., Qasim, M.A., Qasim, S., Warrington, T.L., Laskowski Jr., M., (2006) Biochim. Biophys. Acta, 1760, pp. 372-379
Boldyrev, A., Bulygina, E., Leinsoo, T., Petrushanko, I., Tsubone, S., Abe, H., (2004) Comp. Biochem. Physiol. Biochem. Mol. Biol., 137, pp. 81-88
Boldyrev, A. A., Johnson, P., (2002) Oxidative Stress at Molecular, Cellular and Organ Levels, pp. 101-113. , Boldyrev A. A., and Johnson P. (Eds), Research Signpost, India
Skulachev, V. P., (2000) Biochemistry (Mosc), 65, pp. 749-750
Mzhelskaya, T. I., Boldyrev, A. A., (1999) Neirokhimiya, 16, pp. 133-144
Petroff, O. A., Hyder, F., Mattson, R. H., Rothman, D. L., (1999) Neurology, 52, pp. 473-478
Bonomo, R. P., Bruno, V., Conte, E., De Guidi, G., La Mendola, D., Maccarrone, G., Nicoletti, F., Vecchio, G., (2003) J. Chem. Soc. Dalton Trans., pp. 4406-4415
Bonomo, R. P., Cucinotta, V., D'Alessandro, F., Impellizzeri, G., Maccarrone, G., Vecchio, G., Rizzarelli, E., (1991) Inorg. Chem., 30, pp. 2708-2713
Mulazzani, Q. G., D'Angelantonio, M., Venturi, M., Hoffman, M. Z., Rodgers, M. A. J., (1986) J. Phys. Chem., 90, pp. 5347-5352
Bonomo, R. P., Maccarrone, G., Rizzarelli, E., Vecchio, G., (2002) Inorg. Chim. Acta, 339, pp. 455-460
Chen, W. -H., Yuan, D. -Q., Fujita, K., (1996) Tetrahedron Lett., 37, pp. 7561-7564
Buxton, G. V., Greenstock, C. L., Helman, W. P., Ross, A. B., (1988) J. Phys. Chem. Ref. Data, 17, pp. 513-886
Bansal, K. M., Sellers, R. M., (1975) J. Phys. Chem., 79, pp. 1775-1780
Patel, R. P., Darley-Usmar, V. M., (1999) Free Radic. Res., 30, pp. 1-9
Decker, E. A., Ivanov, V., Zhu, B. Z., Frei, B., (2001) J. Agric. Food Chem., 49, pp. 511-516
Aachmann, F. L., Otzen, D. E., Larsen, K. L., Wimmer, R., (2003) Protein Eng., 16, pp. 905-912
Song, L. X., Teng, C. F., Yang, Y., (2006) J. Incl. Phenom. Macr. Chem., 54, pp. 221-232
Yi, Z., Qasim, M. A., Qasim, S., Warrington, T. L., Laskowski Jr., M., (2006) Biochim. Biophys. Acta, 1760, pp. 372-379
Several in vitro and in vivo studies have suggested that carnosine (β-alanil-l-histidine) and homocarnosine (β-aminobutyril-l-histidine) can act as scavengers of reactive oxygen species. β-Cyclodextrin was functionalized with homocarnosine, obtaining the following new bioconjugate isomers: 6A-[(4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}-4-oxobutyl)amino]-6A-deoxy-β-cyclodextrin and (2AS,3AR)-3A-[(4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}-4-oxobutyl)amino]-3A-deoxy-β-cyclodextrin. Pulse radiolysis investigations show that the β-cyclodextrin homocarnosine bioconjugates are scavengers of {radical dot}OH radicals because of the formation of stable imidazole-centered radicals and the scavenger ability of glucose molecules of the macrocycle. The ability of these new β-cyclodextrin derivatives to inhibit the copper(II) driven LDL oxidation was determined in comparison with that displayed by the analogous carnosine derivatives. Both the β-cyclodextrin carnosine isomers show a higher protective effect than that of free dipeptide and homocarnosine derivatives, bringing into light the role of the β-CD cavity. The ability of these new β-cyclodextrin derivatives to inhibit the copper(II) driven LDL oxidation was determined in comparison with that displayed by the analogous carnosine derivatives. Both the β-cyclodextrin carnosine isomers show a higher protective effect than that of free dipeptide and homocarnosine derivatives, bringing into light the role of the β-CD cavity. © 2007 Elsevier Masson SAS. All rights reserved.
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Google Patents, 2016 Feb 04; CA2951808A1: CA2951808-CA2951808.
Impact Factor: 0
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Bellia F, Rizzarelli E, Vecchio G
* The chemistry of carnosine derivatives (188 visite)
Food And Nutritional Components In Focus (ISSN: 2045-1695), 2015; 2015-January(8): 61-83.
Impact Factor: 0
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Grasso GI, Arena G, Bellia F, Rizzarelli E, Vecchio G
* Copper(II)-chelating homocarnosine glycoconjugate as a new multifunctional compound (251 visite)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2014 Feb; 131: 56-63.
Impact Factor: 3.444
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Bellia F, Vecchio G, Rizzarelli E
* Carnosinases, Their Substrates And Diseases (251 visite)
Molecules (ISSN: 1420-3049, 1420-3049electronic, 1420-3049linking), 2014; 19(2): 2299-2329.
Impact Factor: 2.416
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Bellia F, Vecchio G, Rizzarelli E
* Carnosine and Cognitive Deficits (66 visite)
Diet And Nutr In Dement And Cogn Decline (ISSN: 9780-1240793979780124078246), 2014; N/D: 973-982.
Impact Factor: 0
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Villari V, Attanasio F, Micali N
* Control of the structural stability of α-crystallin under thermal and chemical stress: The role of carnosine (273 visite)
J Phys Chem B (ISSN: 1520-6106, 1520-5207), 2014; 118(47): 13770-13776.
Impact Factor: 3.302
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Bellia F, Oliveri V, Rizzarelli E, Vecchio G
* New derivative of carnosine for nanoparticle assemblies (277 visite)
Eur J Med Chem (ISSN: 1768-3254, 0223-5234, 1768-3254electronic), 2013 Dec; 70: 225-232.
Impact Factor: 3.432
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Attanasio F, Convertino M, Magno A, Caflisch A, Corazza A, Haridas H, Esposito G, Cataldo S, Pignataro B, Milardi D, Rizzarelli E
* Carnosine Inhibits Abeta(42) Aggregation By Perturbing The H-Bond Network In And Around The Central Hydrophobic Cluster (328 visite)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2013 Mar 18; 14(5): 583-592.
Impact Factor: 3.06
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Scalia M, Satriano C, Greca R, Stella AM, Rizzarelli E, Spina-Purrello V
* PARP-1 inhibitors DPQ and PJ-34 negatively modulate proinflammatory commitment of human glioblastoma cells (279 visite)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2013 Jan; 38(1): 50-58.
Impact Factor: 2.551
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Bellia F, Vecchio G, Rizzarelli E
* Carnosine derivatives: new multifunctional drug-like molecules (269 visite)
Amino Acids (ISSN: 1438-2199, 0939-4451, 1438-2199electronic), 2012 Jul; 43(1): 153-163.
Impact Factor: 3.914
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Perrone-Filardi P, Musella F, Savarese G, Cecere M, Marciano C, Scala O, Rengo G, Dellegrottaglie S, Cuocolo A, Leosco D
* Coronary computed tomography: current role and future perspectives for cardiovascular risk stratification (262 visite)
Eur Heart J-Card Img (ISSN: 2047-2412, 2047-2404, 2047-2412electronic), 2012 Jun; 13(6): 453-458.
Impact Factor: 3.669
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Santulli G, Cipolletta E, Sorriento D, Del Giudice C, Anastasio A, Monaco S, Maione AS, Condorelli G, Puca A, Trimarco B, Illario M, Iaccarino G
* CaMK4 gene deletion induces hypertension (228 visite)
J Am Heart Assoc Journal Of The American Heart Association (ISSN: 2047-9980), 2012; 1(4): N/D-N/D.
Impact Factor: 2.882
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Di Paola R, Impellizzeri D, Salinaro AT, Mazzon E, Bellia F, Cavallaro M, Cornelius C, Vecchio G, Calabrese V, Rizzarelli E, Cuzzocrea S
* Administration of carnosine in the treatment of acute spinal cord injury (306 visite)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 1873-2968, 0006-2952), 2011 Nov 15; 82(10): 1478-1489.
Impact Factor: 4.705
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Grasso GI, Arena G, Bellia F, Maccarrone G, Parrinello M, Pietropaolo A, Vecchio G, Rizzarelli E
* Intramolecular weak interactions in the thermodynamic stereoselectivity of copper(II) complexes with carnosine-trehalose conjugates (306 visite)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2011 Sep 16; 17(34): 9448-9455.
Impact Factor: 5.925
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Calabrese V, Cornelius C, Cuzzocrea S, Iavicoli I, Rizzarelli E, Calabrese EJ
* Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity (371 visite)
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 279-304.
Impact Factor: 9.97
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Bellia F, Vecchio G, Cuzzocrea S, Calabrese V, Rizzarelli E
* Neuroprotective features of carnosine in oxidative driven diseases (206 visite)
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 258-266.
Impact Factor: 9.97
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Grasso GI, Bellia F, Arena G, Vecchio G, Rizzarelli E
* Noncovalent interaction-driven stereoselectivity of copper(II) complexes with cyclodextrin derivatives of L- and D-carnosine (1088 visite)
Inorg Chem (ISSN: 1520-510x, 0020-1669, 1520-510xelectronic), 2011 Jun 6; 50(11): 4917-4924.
Impact Factor: 4.601
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Corona C, Frazzini V, Silvestri E, Lattanzio R, La Sorda R, Piantelli M, Canzoniero LM, Ciavardelli D, Rizzarelli E, Sensi SL
* Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice (301 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2011 Mar 15; 6(3): e17971-e17971.
Impact Factor: 4.092
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Lanza V, Bellia F, D'Agata R, Grasso G, Rizzarelli E, Vecchio G
* New glycoside derivatives of carnosine and analogs resistant to carnosinase hydrolysis: synthesis and characterization of their copper(II) complexes (264 visite)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2011 Feb; 105(2): 181-188.
Impact Factor: 3.354
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Spina-Purrello V, Giliberto S, Barresi V, Nicoletti VG, Giuffrida Stella AM, Rizzarelli E
* Modulation of PARP-1 and PARP-2 expression by L-carnosine and trehalose after LPS and INFγ-induced oxidative stress (265 visite)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2010 Dec; 35(12): 2144-2153.
Impact Factor: 2.608
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Giacco R, Clemente G, Cipriano D, Luongo D, Viscovo D, Patti L, Di Marino L, Giacco A, Naviglio D, Bianchi MA, Ciati R, Brighenti F, Rivellese AA, Riccardi G
* Effects of the regular consumption of wholemeal wheat foods on cardiovascular risk factors in healthy people (260 visite)
Nutrition (ISSN: 0939-4753, 1590-3729electronic), 2010 Mar; 20(3): 186-194.
Impact Factor: 3.438
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Capaccio D, Ciccodicola A, Sabatino L, Casamassimi A, Pancione M, Fucci A, Febbraro, Merlino A, Graziano G, Colantuoni V
* A novel germline mutation in Peroxisome Proliferator-Activated Receptor γ gene associated with large intestine polyp formation and dyslipidemia (204 visite)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2010; 1802(6): 572-581.
Impact Factor: 2.773
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Cigliano L, Pugliese CR, Spagnuolo MS, Palumbo R, Abrescia P
* Haptoglobin binds the antiatherogenic protein apolipoprotein e - Impairment of apolipoprotein e stimulation of both lecithin: Cholesterol acyltransferase activity and cholesterol uptake by hepatocytes (259 visite)
Febs J (ISSN: 1742-464x), 2009 Nov; 276(21): 6158-6171.
Impact Factor: 3.042
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Attanasio F, Cataldo S, Fisichella S, Nicoletti S, Nicoletti VG, Pignataro B, Savarino A, Rizzarelli E
* Protective effects of L- and D-carnosine on alpha-crystallin amyloid fibril formation: implications for cataract disease (206 visite)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2009 Jul 14; 48(27): 6522-6531.
Impact Factor: 3.226
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La Mendola D, Bonomo RP, Caminati S, Di Natale G, Emmi SS, Hansson O, Maccarrone G, Pappalardo G, Pietropaolo A, Rizzarelli E
* Copper(II) complexes with an avian prion N-terminal region and their potential SOD-like activity (259 visite)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2009 Feb; 103(2): 195-204.
Impact Factor: 3.252
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Calabrese V, Cornelius C, Mancuso C, Barone E, Calafato S, Bates T, Rizzarelli E, Kostova AT
* Vitagenes, dietary antioxidants and neuroprotection in neurodegenerative diseases (345 visite)
Frontiers In Bioscience (ISSN: 1093-4715, 1093-9946), 2009 Jan 1; 14: 376-397.
Impact Factor: 3.736
Dettagli Esporta in BibTeX Esporta in EndNote
Calabrese V, Cornelius C, Mancuso C, Pennisi G, Calafato S, Bellia F, Bates TE, Giuffrida Stella AM, Schapira T, Dinkova Kostova AT, Rizzarelli E
* Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity (476 visite)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2008 Dec; 33(12): 2444-2471.
Impact Factor: 2.26
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Bellia F, Amorini AM, La Mendola D, Vecchio G, Tavazzi B, Giardina B, Di Pietro V, Lazzarino G, Rizzarelli E
* New glycosidic derivatives of histidine-containing dipeptides with antioxidant properties and resistant to carnosinase activity (274 visite)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2008 Feb; 43(2): 373-380.
Impact Factor: 2.882
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Calabrese V, Mancuso C, Calvani M, Rizzarelli E, Butterfield DA, Stella AM
* Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity (327 visite)
Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775.
Impact Factor: 24.52
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Nicoletti VG, Santoro AM, Grasso G, Vagliasindi LI, Giuffrida ML, Cuppari C, Purrello VS, Stella AMG, Rizzarelli E
* Carnosine interaction with nitric oxide and astroglial cell protection (409 visite)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Sep 1; 85(10): 2239-2245.
Impact Factor: 3.268
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Cuzzocrea S, Genovese T, Failla M, Vecchio G, Fruciano M, Mazzon E, Di Paola R, Muià C, La Rosa C, Crimi N, Rizzarelli E, Vancheri C
* Protective effect of orally administered carnosine on bleomycin-induced lung injury (252 visite)
Am J Physiol Lung Cell Mol Physiol (ISSN: 1040-0605), 2007 May; 292(5): L1095-L1095.
Impact Factor: 4.214
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Bellia F, La Mendola D, Maccarrone G, Mineo P, Vitalini D, Scamporrino E, Sortino S, Vecchio G, Rizzarelli E
* Copper(II) Complexes With Beta-Cyclodextrin-Homocarnosine Conjugates And Their Antioxidant Activity (158 visite)
Inorg Chim Acta (ISSN: 0020-1693), 2007 Feb 15; 360(3): 945-954.
Impact Factor: 1.713
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Calabrese V, Colombrita C, Guagliano E, Sapienza M, Ravagna A, Cardile V, Scapagnini G, Santoro AM, Mangiameli A, Butterfield DA, Giuffrida Stella AM, Rizzarelli E
* Protective effect of carnosine during nitrosative stress in astroglial cell cultures (211 visite)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2005 Jun; 30(6-7): 797-807.
Impact Factor: 2.187
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La Rosa C, Milardi D, Amato E, Pappalardo M, Grasso D
* Molecular mechanism of the inhibition of cytochrome c aggregation by Phe-Gly (323 visite)
Arch Biochem Biophys (ISSN: 0003-9861), 2005 Mar 1; 435(1): 182-189.
Impact Factor: 3.152
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Giacco R, Clemente G, Luongo D, Lasorella G, Fiume I, Brouns F, Bornet F, Patti L, Cipriano P, Rivellese AA, Riccardi G
* Effects of short-chain fructo-oligosaccharides on glucose and lipid metabolism in mild hypercholesterolaemic individuals (257 visite)
Clin Nutr (ISSN: 0261-5614, 0261-5614linking), 2004 Jun; 23(3): 331-340.
Impact Factor: 2.019
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Mineo P, Vitalini D, La Mendola D, Rizzarelli E, Scamporrino E, Vecchio G
* Coordination Features Of Difunctionalized Beta-Cyclodextrins With Carnosine: Esi-Ms And Spectroscopic Investigations On 6a, 6d-Di-(beta-Alanyl-L-Histidine)-6a, 6d-Dideoxy-Beta-Cyclodextrin And 6a, 6c-Di-(beta-Alanyl-L-Histidine)-6a, 6c-Dideoxy-Beta-Cyclodextrin And Their Copper (ii) Complexes (211 visite)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2004 Feb; 98(2): 254-265.
Impact Factor: 2.225
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Pauciullo P, Giannino A, De Michele M, Gentile M, Liguori R, Argiriou A, Carlotto A, Faccenda F, Mancini M, Bond MG, De Simone V, Rubba P
* Increased carotid artery intima-media thickness is associated with a novel mutation of low-density lipoprotein receptor independently of major cardiovascular risk factors (340 visite)
Metab Clin Exp (ISSN: 0026-0495, 1532-8600), 2003; 52(11): 1433-1438.
Impact Factor: 2.013
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Bonomo RP, Bruno V, Conte E, De Guidi G, La Mendola D, Maccarrone G, Nicoletti F, Rizzarelli E, Sortino S, Vecchio G
* Potentiometric, spectroscopic and antioxidant activity studies of SOD mimics containing carnosine (262 visite)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2003; (23): 4406-4415.
Impact Factor: 2.908
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Colao A, Di Somma C, Pivonello R, Cuocolo A, Spinelli L, Bonaduce D, Salvatore M, Lombardi G
* The cardiovascular risk of adult GH deficiency (GHD) improved after GH replacement and worsened in untreated GHD: A 12-month prospective study (201 visite)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2002 Mar; 87(3): 1088-1093.
Impact Factor: 5.199
Dettagli Esporta in BibTeX Esporta in EndNote
Mineo P, Vitalini D, La Mendola D, Rizzarelli E, Scamporrino E, Vecchio G
* Electrospray mass spectrometric studies of L-carnosine (β-alanyl-L-histidine) complexes with copper(II) or zinc ions in aqueous solution (272 visite)
Rapid Commun Mass Sp (ISSN: 0951-4198, 1097-0231electronic, 0951-4198linking), 2002; 16(7): 722-729.
Impact Factor: 2.372
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La Mendola D, Sortino S, Rizzarelli E, Vecchiog
* Synthesis Of New Carnosine Derivatives Of R-Cyclodextrin And Their Hydroxyl Radical Scavanger Ability (189 visite)
Helvetica Chimica Acta, 2002; 85: 1633-1643.
Impact Factor: 1.394
Dettagli Esporta in BibTeX Esporta in EndNote
Vecchio G, La Mendola D, Rizzarelli E, Sortino S
* SOD-like activity of copper(II) complexes of beta-cyclodextrins functionalized with carnosine (188 visite)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2001 Sep; 86(1): N/D-N/D.
Impact Factor: 1.729
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Tabbì G, Nauser T, Koppenol WH, Reedijk J
A Pulse Radiolysis Study of an Imidazolato-Bridged Asymmetric Dicopper(II) Complex: A Structural and Functional Mimic of Superoxide Dismutase (175 visite)
Eur J Inorg Chem (ISSN: 1434-1948, 1099-0682e), 1998; (12): 1939-1943.
Impact Factor: 2.222
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45 Records (42 escludendo Abstract e Conferenze).
Impact factor totale: 167.327 (157.292 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 176.787 (164.54 escludendo Abstract e Conferenze).
Impact factor totale: 167.327 (157.292 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 176.787 (164.54 escludendo Abstract e Conferenze).
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Ultima modifica di Marco Comerci in data Thursday 19 March 2015, 14:22:36
228 visite. Ultima visita in data Monday 30 March 2020, 19:05:37
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