Synthesis and biological evaluation of cyclic and branched peptide analogues as ligands for cholecystokinin type 1 receptor(334 views visite) De Luca S, De Capua A, Saviano M, Della Moglie R, Aloj L, Tarallo L, Pedone C, Morelli G
Istituto di Biostrutture e Bioimmagini CNR, & Centro Interuniversitario per la Ricerca sui Peptidi Bioattivi (CIRPeB), via Mezzocannone, Napoli, Italy. Department of Nuclear Medicine, Unit of Animal Experimentation, Istituto Nazionale per lo Studio e la Cura dei Tumori, via M. Semmola, 80131 Napoli, Italy
References Riferimenti: Mutt, V., Cholecystokinin: Isolation, Structure and Functions (1980) Gastrointestinal Hormones, pp. 169-221. , Glass G.B.J. (Ed), Raven Press, New Yor
Vanderhaeghen, J.J., Crawley, J.N., (1985) Ann. N. Y. Acad. Sci., p. 448
Crawley, J.N., Corwin, R.L., (1994) Peptides, 15, pp. 731-755
Dourish, C.T., Hill, D.R., (1987) Trends Pharmacol. Sci., 8, pp. 207-208
Wank, S.A., (1995) Am. J. Physiol., 269, pp. 628-646
Noble, F., Wank, S.A., Crawley, J.N., Bradwejn, J., Seroogy, K.B., Hamon, M., Roques, B.P., (1999) Pharmacol. Rev., 51, pp. 745-781
Dufresne, M., Seva, C., Fourmy, D., (2006) Physiol. Rev., 86, pp. 805-847
de Tullio, P., Delarge, J., Pirotte, B., (1999) Curr. Med. Chem., 6, pp. 433-455
Herranz, R., (2003) Med. Res. Rev., 23, pp. 559-605
Reubi, J.C., Schaer, J.C., Waser, B., (1997) Cancer Res., 57, pp. 1377-1386
Mierke, D.F., Pellegrini, M., (1999) Biochemistry, 38, pp. 14775-14783
Giragossian, C., Mierke, D.F., (2001) Biochemistry, 40, pp. 3804-3809
Harikumar, K.G., Clain, J., Pinon, D.I., Dong, M., Miller, L.J., (2005) J. Biol. Chem., 280, pp. 1044-1050
Fourmy, D., Escrieut, C., Archer, E., Gales, C., Gogoux, V., Maigret, B., Moroder, L., Pradayrol, L., (2002) Pharmacol. Toxicol., 9, pp. 313-320
De Luca, S., Ragone, R., Bracco, C., Digilio, G., Aloj, L., Tesauro, D., Saviano, M., Morelli, G., (2003) ChemBiolChem, 4, pp. 1176-1187
De Luca, S., Della Moglie, R., De Capua, A., Saviano, M., Morelli, G., (2005) Tetrahedron Lett., 46, pp. 6637-6640
Wüthrich, K., (1986) NMR of Proteins and Nucleic Acids, , Wiley, New York
Archer-Lahlou, E., Tikhonova, I., Escrieut, C., Dufresne, M., Seva, C., Pradayrol, L., Moroder, L., Fourmy, D., (2005) J. Med. Chem., 48, pp. 180-191
Hwang, T.L., Shaka, A.J., (1995) J. Magn. Reson., 65, pp. 275-279
Braunschwetler, R., Ernst, R., (1983) J. Magn. Reson., 53, pp. 521-528
Rance, M., Sorensen, O.W., Bodenhausen, G., Wagner, G., Ernst, R.R., Wuthrich, K., (1983) Biochem. Biophys. Res. Commun., 117, pp. 479-485
Kumar, A., Ernst, R.R., Wuthrich, K., (1980) Biochem. Biophys. Res. Commun., 95, pp. 1-6
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Vanderhaeghen, J. J., Crawley, J. N., (1985) Ann. N. Y. Acad. Sci., p. 448
Crawley, J. N., Corwin, R. L., (1994) Peptides, 15, pp. 731-755
Dourish, C. T., Hill, D. R., (1987) Trends Pharmacol. Sci., 8, pp. 207-208
Wank, S. A., (1995) Am. J. Physiol., 269, pp. 628-646
Noble, F., Wank, S. A., Crawley, J. N., Bradwejn, J., Seroogy, K. B., Hamon, M., Roques, B. P., (1999) Pharmacol. Rev., 51, pp. 745-781
Reubi, J. C., Schaer, J. C., Waser, B., (1997) Cancer Res., 57, pp. 1377-1386
Mierke, D. F., Pellegrini, M., (1999) Biochemistry, 38, pp. 14775-14783
Harikumar, K. G., Clain, J., Pinon, D. I., Dong, M., Miller, L. J., (2005) J. Biol. Chem., 280, pp. 1044-1050
W thrich, K., (1986) NMR of Proteins and Nucleic Acids, , Wiley, New York
Jensen, R. T., Wank, S. A., Rowley, W. H., Sato, S., Gardner, J. D., (1989) Trends Pharmacol. Sci., 10, pp. 418-423
Hwang, T. L., Shaka, A. J., (1995) J. Magn. Reson., 65, pp. 275-279
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Synthesis and biological evaluation of cyclic and branched peptide analogues as ligands for cholecystokinin type 1 receptor
A library of cyclic CCK8 analogues, containing unnatural amino acids in the peptide sequence, is prepared using solid-phase synthesis. The structure of these cyclic peptides is based on a previously synthesised compound, cyclo-CCK8, selective for CCK(1) receptor. Structure-activity investigations are performed by evaluating the binding properties of the new analogues. In particular, the binding ability of the cyclic CCK8 analogues is tested by nuclear medicine studies on cell line transfected with CCK(1) receptor. Compounds named cyclo-A4-cyclo-A7 show binding constant in the range 6.0-8.0 microM, with an improved affinity over the previous described cyclo-CCK8, but almost comparable IC(50) values among new analogues towards CCK(1) were obtained.
Synthesis and biological evaluation of cyclic and branched peptide analogues as ligands for cholecystokinin type 1 receptor
Aloj L, Aurilio M, Rinaldi V, D'Ambrosio L, Tesauro D, Peitl PK, Maina T, Mansi R, Von Guggenberg E, Joosten L, Sosabowski JK, Breeman WA, De Blois E, Koelewijn S, Melis M, Waser B, Beetschen K, Reubi JC, De Jong M * The EEE project(387 visite) Proc Int Cosm Ray Conf Icrc Universidad Nacional Autonoma De Mexico, 2007; 5(HEPART2): 977-980. Impact Factor:0 DettagliEsporta in BibTeXEsporta in EndNote
569 Records (560 escludendo Abstract e Conferenze). Impact factor totale: 2123.849 (2090.971 escludendo Abstract e Conferenze). Impact factor a 5 anni totale: 2169.039 (2129.169 escludendo Abstract e Conferenze).
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