A short PNA targeting coxsackievirus B3 5′-nontranslated region prevents virus-induced cytolysis (126 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Mar; 12(3): 161-170.
Tipo di articolo: Journal Article, Comparative Study,
Impact factor: 1.801, Impact factor a 5 anni: 1.715
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-33644801965&partnerID=40&md5=32660e12ee16bbcab8d097667a27c17d
Parole chiave: 3c Protease, Coxsackievirus B3, Rhinovirus, Viral Rna, Genomic Rna, Oligonucleotide, Peptide Nucleic Acid, Untranslated Region, Article, Base Pairing, Cell Transport, Chemosensitivity, Complex Formation, Controlled Study, Coxsackie Virus B3, Cytolysis, Drug Design, Drug Purification, Drug Synthesis, Enzyme Degradation, Gene Targeting, Human, Human Cell, Kinetics, Molecular Recognition, Nonhuman, Peptide Analysis, Priority Journal, Protein Stability, Protein Synthesis, Protein Targeting, Regulatory Rna Sequence, Rna Binding, Rna Structure, Thermodynamics, Virus Inhibition, Antiviral Agents, Cell Proliferation, Cultured, Coxsackievirus Infections, Cytopathogenic Effect, Dose-Response Relationship, Enterovirus B, Hela Cells, Microbial Sensitivity Tests, Structure-Activity Relationship, Chemical Synthesis, Chemistry, Pharmacology, Drug Effects, Virology, Genetics,
Affiliazioni:
*** IBB - CNR ***
Instituto di Biostrutture e Bioimmagini, CNR, Via Mezzocannone 16, I-80134 Naples, Italy
Abteilung Molekulare Biophysik and NMR-Spektrikopie, Institut für Molekulare Biotechnologie, D-07741 Jena, Germany
Institut für Virologie und Antivirale Therapie, Friedrich-Schiller-Universität, D-07445 Jena, Germany
Institut f r Virologie und Antivirale Therapie, Friedrich-Schiller-Universit t, D-07445 Jena, Germany
Istituto di Biostrutture e Bioimmagini, CNR, I-80134 Naples, Italy.,
Riferimenti:
Dean, N.M., Functional genomics and target validation approaches using antisense oligonucleotide, technology (2001) Curr. Opin. Biotechnol., 12, pp. 622-62
Gao, W.Y., Han, F.S., Storm, C., Egan, W., Cheng, Y.C., Phosphorothioate oligonucleotides are inhibitors of human DNA polymerases and RNase H: Implications for antisense technology (1992) Mol. Pharmacol., 41, pp. 223-229
Armitage, B.A., The impact of nucleic acid secondary structure on PNA hybridization (2003) Drug Discov. Today, 8, pp. 222-228
Nielsen, P.E., Peptide nucleic acids as therapeutic agents (1999) Curr. Opin. Struct. Biol., 9, pp. 353-357
Rebuffat, A.G., Nawrocki, A.R., Nielsen, P.E., Bernasconi, A.G., Bernal-Mendez, E., Frey, B.M., Frey, F.J., Gene delivery by a steroid-peptide nucleic acid conjugate (2002) FASEB J., 16, pp. 1426-1428
Lewis, M.R., Jia, F., Gallazzi, F., Wang, Y., Zhang, J., Shenoy, N., Lever, S.Z., Hannink, M., Radiometal-labeled peptide-PNA conjugates for targeting bcl-2 expression: Preparation, characterization, and in vitro mRNA binding (2002) Bioconjug. Chem., 13, pp. 1176-1180
Eriksson, M., Nielsen, P.E., Good, L., Cell permeabilization and uptake of antisense peptide-peptide nucleic acid (PNA) into Escherichia coli (2002) J. Biol. Chem., 277, pp. 7144-7147
Svanvik, N., Nygren, J., Westman, G., Kubista, M., Free-probe fluorescence of light-up probes (2001) J. Am. Chem. Soc., 123, pp. 803-809
Friebe, P., Lohmann, V., Krieger, N., Bartenschlager, R., Sequences in the 5′ nontranslated region of hepatitis C virus required for RNA replication (2001) J. Virol., 75, pp. 12047-12057
Becher, P., Orlich, M., Thiel, H.J., Mutations in the 5′ nontranslated region of bovine viral diarrhea virus result in altered growth characteristics (2000) J. Virol., 74, pp. 7884-7894
Kusov, Y.Y., Gauss-Muller, V., In vitro RNA binding of the hepatitis A virus protienase 3C (HAV 3Cpro) to secondary structure elements within the 5′ terminus of the HAV genome (1997) RNA, 3, pp. 291-302
Kim, K.H., Hemenway, C., The 5′ nontranslated region of potato virus X RNA affects both genomic and subgenomic RNA synthesis (1996) J. Virol., 70, pp. 5533-5540
Basso, J., Dallaire, P., Charest, P.J., Devantier, Y., Laliberte, J.F., Evidence for an internal ribosome entry site within the 5′ non-translated region of turnip mosaic potyvirus RNA (1994) J. Gen. Virol., 75 (PART 11), pp. 3157-3165
Lyons, T., Murray, K.E., Roberts, A.W., Barton, D.J., Poliovirus 5′-terminal cloverleaf RNA is required in cis for VPg uridylylation and the initiation of negative-strand RNA synthesis (2001) J. Virol., 75, pp. 10696-10708
Richards, O.C., Ehrenfeld, E., Poliovirus RNA replication (1990) Curr. Top. Microbiol. Immunol., 161, pp. 89-119
Wimmer, E., Kuhn, R.J., Pincus, S., Yang, C.F., Toyoda, H., Nicklin, M.D., Takeda, N., Molecular events leading to picornavirus genome replication (1987) J. Cell Sci. Suppl., 7, pp. 251-276
Santti, J., Vainionpaa, R., Hyypia, T., Molecular detection and typing of human picornaviruses (1999) Virus Res., 62, pp. 177-183
Wang, Q.M., Protease inhibitors as potential antiviral agents for the treatment of picornaviral infections (2001) Prog. Drug Res., 52 (SPEC. ISSUE), pp. 229-253
Kong, J.S., Venkatraman, S., Furness, K., Nimkar, S., Shepherd, T.A., Wang, Q.M., Aube, J., Hanzlik, R.P., Synthesis and evaluation of peptidyl Michael acceptors that inactivate human rhinovirus 3C protease and inhibit virus replication (1998) J. Med. Chem., 41, pp. 2579-2587
Andino, R., Rieckhof, G.E., Baltimore, D., A functional ribonucleoprotein complex forms around the 5′ end of poliovirus RNA (1990) Cell, 63, pp. 369-380
Zell, R., Sidigi, K., Bucci, E., Stelzner, A., Gorlach, M., Determinants of the recognition of enteroviral cloverleaf RNA by coxsackievirus B3 proteinase 3C (2002) RNA, 8, pp. 188-201
Ohlenschlager, O., Wohnert, J., Bucci, E., Seitz, S., Hafner, S., Ramachandran, R., Zell, R., Gorlach, M., The structure of the stemloop D subdomain of coxsackievirus B3 cloverleaf RNA and its interaction with the proteinase 3C (2004) Structure, 12, pp. 237-248
Hingamp, P., van den Brock, A.E., Stoesser, G., Baker, W., The EMBL nucleotide sequence database. Contributing and accessing data (1999) Mol. Biotechnol., 12, pp. 255-267
Skripkin, E.A., Jacobson, A.B., A two-dimensional model at the nucleotide level for the central hairpin of coliphage Q β RNA (1993) J. Mol. Biol., 233, pp. 245-260
Pace, C.N., Vajdos, F., Fee, L., Grimsley, G., Gray, T., How to measure and predict the molar absorption coefficient of a protein (1995) Protein Sci., 4, pp. 2411-2423
Schmidtke, M., Schnittler, U., Jahn, B., Dahse, H., Stelzner, A., A rapid assay for evaluation of antiviral activity against coxsackievirus B3, influenza virus A, and herpes simplex virus type 1 (2001) J. Virol. Methods, 95, pp. 133-143
Isernia, C., Bucci, E., Leone, M., Zaccaro, L., Di Lello, P., Digilio, G., Esposito, S., Fattorusso, R., NMR structure of the single QALGGH zinc finger domain from the Arabidopsis thaliana SUPERMAN protein (2003) Chem Biochem, 4, pp. 171-180
Sosnick, T.R., Fang, X., Shelton, V.M., Application of circular dichroism to study RNA folding transitions (2000) Meth. Enzymol., 317, pp. 393-409
Koppelhus, U., Nielsen, P.E., Cellular delivery of peptide nucleic acid (PNA) (2003) Adv. Drug Deliv. Rev., 55, pp. 267-280
Wang, G., Xu, X.S., Peptide nucleic acid (PNA) binding-mediated gene regulation (2004) Cell Res., 14, pp. 111-116
Filipovska, A., Eccles, M.R., Smith, R.A., Murphy, M.P., Delivery of antisense peptide nucleic acids (PNAs) to the cytosol by disulphide conjugation to a lipophilic cation (2004) FEBS Lett., 556, pp. 180-186
Sazani, P., Kang, S.H., Mauer, M.A., Wie, C., Dillman, J., Summerton, J., Manoharan, M., Kole, R., Nuclear antisense effects of neutral, anionic and cationic oligonucleotide analogs (2001) Nucleic Acids Res., 29, pp. 3965-3974
Kole, R., Williams, T., Cohen, L., RNA modulation, repair and remodeling by splice switching oligonucleotides (2004) Acta Biochim Pol., 51, pp. 373-378
Moulton, H., Moulton, J.D., Peptide-assisted delivery of steric-blocking antisense oligomers (2003) Curr. Opin. Mol. Ther., 5, pp. 123-132
Koppelhus, U., Zachar, V., Nielsen, P.E., Liu, X., Eugen-Olsen, J., Ebbesen, P., Efficient in vitro inhibition of HIV-1 gag reverse transcription by peptide nucleic acid (PNA) at minimal ratios of PNA/RNA (1997) Nucleic Acids Res., 25, pp. 2167-2173
Terreux, R., Pairot, S., Cabrol-Bass, D., Patino, N., Condom, R., Interaction of new PNA-based molecules with TAR RNA of HIV-1: Molecular modelling and biological evaluation (2001) J. Mol. Graph., 19, pp. 579-585
Lee, R., Kaushik, N., Modak, M.J., Vinayak, R., Pandey, V.N., Polyamide nucleic acid targeted to the primer binding site of the HIV-1 RNA genome blocks in vitro HIV-1 reverse transcription (1998) Biochemistry, 37, pp. 900-910
Rozhon, E., Cox, S., Buontempo, P., O'Connell, J., Slater, W., De Martino, J., Schwartz, J., Zhang, A., SCH 38057: A picornavirus capsid-binding molecule with antiviral activity after the initial stage of viral uncoating (1993) Antiviral Res., 21, pp. 15-35
Dean, N. M., Functional genomics and target validation approaches using antisense oligonucleotide, technology (2001) Curr. Opin. Biotechnol., 12, pp. 622-62
Gao, W. Y., Han, F. S., Storm, C., Egan, W., Cheng, Y. C., Phosphorothioate oligonucleotides are inhibitors of human DNA polymerases and RNase H: Implications for antisense technology (1992) Mol. Pharmacol., 41, pp. 223-229
Armitage, B. A., The impact of nucleic acid secondary structure on PNA hybridization (2003) Drug Discov. Today, 8, pp. 222-228
Nielsen, P. E., Peptide nucleic acids as therapeutic agents (1999) Curr. Opin. Struct. Biol., 9, pp. 353-357
Rebuffat, A. G., Nawrocki, A. R., Nielsen, P. E., Bernasconi, A. G., Bernal-Mendez, E., Frey, B. M., Frey, F. J., Gene delivery by a steroid-peptide nucleic acid conjugate (2002) FASEB J., 16, pp. 1426-1428
Lewis, M. R., Jia, F., Gallazzi, F., Wang, Y., Zhang, J., Shenoy, N., Lever, S. Z., Hannink, M., Radiometal-labeled peptide-PNA conjugates for targeting bcl-2 expression: Preparation, characterization, and in vitro mRNA binding (2002) Bioconjug. Chem., 13, pp. 1176-1180
Kusov, Y. Y., Gauss-Muller, V., In vitro RNA binding of the hepatitis A virus protienase 3C (HAV 3Cpro) to secondary structure elements within the 5 terminus of the HAV genome (1997) RNA, 3, pp. 291-302
Kim, K. H., Hemenway, C., The 5 nontranslated region of potato virus X RNA affects both genomic and subgenomic RNA synthesis (1996) J. Virol., 70, pp. 5533-5540
Richards, O. C., Ehrenfeld, E., Poliovirus RNA replication (1990) Curr. Top. Microbiol. Immunol., 161, pp. 89-119
Wang, Q. M., Protease inhibitors as potential antiviral agents for the treatment of picornaviral infections (2001) Prog. Drug Res., 52 (SPEC. ISSUE), pp. 229-253
Kong, J. S., Venkatraman, S., Furness, K., Nimkar, S., Shepherd, T. A., Wang, Q. M., Aube, J., Hanzlik, R. P., Synthesis and evaluation of peptidyl Michael acceptors that inactivate human rhinovirus 3C protease and inhibit virus replication (1998) J. Med. Chem., 41, pp. 2579-2587
Skripkin, E. A., Jacobson, A. B., A two-dimensional model at the nucleotide level for the central hairpin of coliphage Q RNA (1993) J. Mol. Biol., 233, pp. 245-260
Pace, C. N., Vajdos, F., Fee, L., Grimsley, G., Gray, T., How to measure and predict the molar absorption coefficient of a protein (1995) Protein Sci., 4, pp. 2411-2423
Sosnick, T. R., Fang, X., Shelton, V. M., Application of circular dichroism to study RNA folding transitions (2000) Meth. Enzymol., 317, pp. 393-409
Wang, G., Xu, X. S., Peptide nucleic acid (PNA) binding-mediated gene regulation (2004) Cell Res., 14, pp. 111-116
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Mar; 12(3): 161-170.
Tipo di articolo: Journal Article, Comparative Study,
Impact factor: 1.801, Impact factor a 5 anni: 1.715
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-33644801965&partnerID=40&md5=32660e12ee16bbcab8d097667a27c17d
Parole chiave: 3c Protease, Coxsackievirus B3, Rhinovirus, Viral Rna, Genomic Rna, Oligonucleotide, Peptide Nucleic Acid, Untranslated Region, Article, Base Pairing, Cell Transport, Chemosensitivity, Complex Formation, Controlled Study, Coxsackie Virus B3, Cytolysis, Drug Design, Drug Purification, Drug Synthesis, Enzyme Degradation, Gene Targeting, Human, Human Cell, Kinetics, Molecular Recognition, Nonhuman, Peptide Analysis, Priority Journal, Protein Stability, Protein Synthesis, Protein Targeting, Regulatory Rna Sequence, Rna Binding, Rna Structure, Thermodynamics, Virus Inhibition, Antiviral Agents, Cell Proliferation, Cultured, Coxsackievirus Infections, Cytopathogenic Effect, Dose-Response Relationship, Enterovirus B, Hela Cells, Microbial Sensitivity Tests, Structure-Activity Relationship, Chemical Synthesis, Chemistry, Pharmacology, Drug Effects, Virology, Genetics,
Affiliazioni:
*** IBB - CNR ***
Instituto di Biostrutture e Bioimmagini, CNR, Via Mezzocannone 16, I-80134 Naples, Italy
Abteilung Molekulare Biophysik and NMR-Spektrikopie, Institut für Molekulare Biotechnologie, D-07741 Jena, Germany
Institut für Virologie und Antivirale Therapie, Friedrich-Schiller-Universität, D-07445 Jena, Germany
Institut f r Virologie und Antivirale Therapie, Friedrich-Schiller-Universit t, D-07445 Jena, Germany
Istituto di Biostrutture e Bioimmagini, CNR, I-80134 Naples, Italy.,
Riferimenti:
Dean, N.M., Functional genomics and target validation approaches using antisense oligonucleotide, technology (2001) Curr. Opin. Biotechnol., 12, pp. 622-62
Gao, W.Y., Han, F.S., Storm, C., Egan, W., Cheng, Y.C., Phosphorothioate oligonucleotides are inhibitors of human DNA polymerases and RNase H: Implications for antisense technology (1992) Mol. Pharmacol., 41, pp. 223-229
Armitage, B.A., The impact of nucleic acid secondary structure on PNA hybridization (2003) Drug Discov. Today, 8, pp. 222-228
Nielsen, P.E., Peptide nucleic acids as therapeutic agents (1999) Curr. Opin. Struct. Biol., 9, pp. 353-357
Rebuffat, A.G., Nawrocki, A.R., Nielsen, P.E., Bernasconi, A.G., Bernal-Mendez, E., Frey, B.M., Frey, F.J., Gene delivery by a steroid-peptide nucleic acid conjugate (2002) FASEB J., 16, pp. 1426-1428
Lewis, M.R., Jia, F., Gallazzi, F., Wang, Y., Zhang, J., Shenoy, N., Lever, S.Z., Hannink, M., Radiometal-labeled peptide-PNA conjugates for targeting bcl-2 expression: Preparation, characterization, and in vitro mRNA binding (2002) Bioconjug. Chem., 13, pp. 1176-1180
Eriksson, M., Nielsen, P.E., Good, L., Cell permeabilization and uptake of antisense peptide-peptide nucleic acid (PNA) into Escherichia coli (2002) J. Biol. Chem., 277, pp. 7144-7147
Svanvik, N., Nygren, J., Westman, G., Kubista, M., Free-probe fluorescence of light-up probes (2001) J. Am. Chem. Soc., 123, pp. 803-809
Friebe, P., Lohmann, V., Krieger, N., Bartenschlager, R., Sequences in the 5′ nontranslated region of hepatitis C virus required for RNA replication (2001) J. Virol., 75, pp. 12047-12057
Becher, P., Orlich, M., Thiel, H.J., Mutations in the 5′ nontranslated region of bovine viral diarrhea virus result in altered growth characteristics (2000) J. Virol., 74, pp. 7884-7894
Kusov, Y.Y., Gauss-Muller, V., In vitro RNA binding of the hepatitis A virus protienase 3C (HAV 3Cpro) to secondary structure elements within the 5′ terminus of the HAV genome (1997) RNA, 3, pp. 291-302
Kim, K.H., Hemenway, C., The 5′ nontranslated region of potato virus X RNA affects both genomic and subgenomic RNA synthesis (1996) J. Virol., 70, pp. 5533-5540
Basso, J., Dallaire, P., Charest, P.J., Devantier, Y., Laliberte, J.F., Evidence for an internal ribosome entry site within the 5′ non-translated region of turnip mosaic potyvirus RNA (1994) J. Gen. Virol., 75 (PART 11), pp. 3157-3165
Lyons, T., Murray, K.E., Roberts, A.W., Barton, D.J., Poliovirus 5′-terminal cloverleaf RNA is required in cis for VPg uridylylation and the initiation of negative-strand RNA synthesis (2001) J. Virol., 75, pp. 10696-10708
Richards, O.C., Ehrenfeld, E., Poliovirus RNA replication (1990) Curr. Top. Microbiol. Immunol., 161, pp. 89-119
Wimmer, E., Kuhn, R.J., Pincus, S., Yang, C.F., Toyoda, H., Nicklin, M.D., Takeda, N., Molecular events leading to picornavirus genome replication (1987) J. Cell Sci. Suppl., 7, pp. 251-276
Santti, J., Vainionpaa, R., Hyypia, T., Molecular detection and typing of human picornaviruses (1999) Virus Res., 62, pp. 177-183
Wang, Q.M., Protease inhibitors as potential antiviral agents for the treatment of picornaviral infections (2001) Prog. Drug Res., 52 (SPEC. ISSUE), pp. 229-253
Kong, J.S., Venkatraman, S., Furness, K., Nimkar, S., Shepherd, T.A., Wang, Q.M., Aube, J., Hanzlik, R.P., Synthesis and evaluation of peptidyl Michael acceptors that inactivate human rhinovirus 3C protease and inhibit virus replication (1998) J. Med. Chem., 41, pp. 2579-2587
Andino, R., Rieckhof, G.E., Baltimore, D., A functional ribonucleoprotein complex forms around the 5′ end of poliovirus RNA (1990) Cell, 63, pp. 369-380
Zell, R., Sidigi, K., Bucci, E., Stelzner, A., Gorlach, M., Determinants of the recognition of enteroviral cloverleaf RNA by coxsackievirus B3 proteinase 3C (2002) RNA, 8, pp. 188-201
Ohlenschlager, O., Wohnert, J., Bucci, E., Seitz, S., Hafner, S., Ramachandran, R., Zell, R., Gorlach, M., The structure of the stemloop D subdomain of coxsackievirus B3 cloverleaf RNA and its interaction with the proteinase 3C (2004) Structure, 12, pp. 237-248
Hingamp, P., van den Brock, A.E., Stoesser, G., Baker, W., The EMBL nucleotide sequence database. Contributing and accessing data (1999) Mol. Biotechnol., 12, pp. 255-267
Skripkin, E.A., Jacobson, A.B., A two-dimensional model at the nucleotide level for the central hairpin of coliphage Q β RNA (1993) J. Mol. Biol., 233, pp. 245-260
Pace, C.N., Vajdos, F., Fee, L., Grimsley, G., Gray, T., How to measure and predict the molar absorption coefficient of a protein (1995) Protein Sci., 4, pp. 2411-2423
Schmidtke, M., Schnittler, U., Jahn, B., Dahse, H., Stelzner, A., A rapid assay for evaluation of antiviral activity against coxsackievirus B3, influenza virus A, and herpes simplex virus type 1 (2001) J. Virol. Methods, 95, pp. 133-143
Isernia, C., Bucci, E., Leone, M., Zaccaro, L., Di Lello, P., Digilio, G., Esposito, S., Fattorusso, R., NMR structure of the single QALGGH zinc finger domain from the Arabidopsis thaliana SUPERMAN protein (2003) Chem Biochem, 4, pp. 171-180
Sosnick, T.R., Fang, X., Shelton, V.M., Application of circular dichroism to study RNA folding transitions (2000) Meth. Enzymol., 317, pp. 393-409
Koppelhus, U., Nielsen, P.E., Cellular delivery of peptide nucleic acid (PNA) (2003) Adv. Drug Deliv. Rev., 55, pp. 267-280
Wang, G., Xu, X.S., Peptide nucleic acid (PNA) binding-mediated gene regulation (2004) Cell Res., 14, pp. 111-116
Filipovska, A., Eccles, M.R., Smith, R.A., Murphy, M.P., Delivery of antisense peptide nucleic acids (PNAs) to the cytosol by disulphide conjugation to a lipophilic cation (2004) FEBS Lett., 556, pp. 180-186
Sazani, P., Kang, S.H., Mauer, M.A., Wie, C., Dillman, J., Summerton, J., Manoharan, M., Kole, R., Nuclear antisense effects of neutral, anionic and cationic oligonucleotide analogs (2001) Nucleic Acids Res., 29, pp. 3965-3974
Kole, R., Williams, T., Cohen, L., RNA modulation, repair and remodeling by splice switching oligonucleotides (2004) Acta Biochim Pol., 51, pp. 373-378
Moulton, H., Moulton, J.D., Peptide-assisted delivery of steric-blocking antisense oligomers (2003) Curr. Opin. Mol. Ther., 5, pp. 123-132
Koppelhus, U., Zachar, V., Nielsen, P.E., Liu, X., Eugen-Olsen, J., Ebbesen, P., Efficient in vitro inhibition of HIV-1 gag reverse transcription by peptide nucleic acid (PNA) at minimal ratios of PNA/RNA (1997) Nucleic Acids Res., 25, pp. 2167-2173
Terreux, R., Pairot, S., Cabrol-Bass, D., Patino, N., Condom, R., Interaction of new PNA-based molecules with TAR RNA of HIV-1: Molecular modelling and biological evaluation (2001) J. Mol. Graph., 19, pp. 579-585
Lee, R., Kaushik, N., Modak, M.J., Vinayak, R., Pandey, V.N., Polyamide nucleic acid targeted to the primer binding site of the HIV-1 RNA genome blocks in vitro HIV-1 reverse transcription (1998) Biochemistry, 37, pp. 900-910
Rozhon, E., Cox, S., Buontempo, P., O'Connell, J., Slater, W., De Martino, J., Schwartz, J., Zhang, A., SCH 38057: A picornavirus capsid-binding molecule with antiviral activity after the initial stage of viral uncoating (1993) Antiviral Res., 21, pp. 15-35
Dean, N. M., Functional genomics and target validation approaches using antisense oligonucleotide, technology (2001) Curr. Opin. Biotechnol., 12, pp. 622-62
Gao, W. Y., Han, F. S., Storm, C., Egan, W., Cheng, Y. C., Phosphorothioate oligonucleotides are inhibitors of human DNA polymerases and RNase H: Implications for antisense technology (1992) Mol. Pharmacol., 41, pp. 223-229
Armitage, B. A., The impact of nucleic acid secondary structure on PNA hybridization (2003) Drug Discov. Today, 8, pp. 222-228
Nielsen, P. E., Peptide nucleic acids as therapeutic agents (1999) Curr. Opin. Struct. Biol., 9, pp. 353-357
Rebuffat, A. G., Nawrocki, A. R., Nielsen, P. E., Bernasconi, A. G., Bernal-Mendez, E., Frey, B. M., Frey, F. J., Gene delivery by a steroid-peptide nucleic acid conjugate (2002) FASEB J., 16, pp. 1426-1428
Lewis, M. R., Jia, F., Gallazzi, F., Wang, Y., Zhang, J., Shenoy, N., Lever, S. Z., Hannink, M., Radiometal-labeled peptide-PNA conjugates for targeting bcl-2 expression: Preparation, characterization, and in vitro mRNA binding (2002) Bioconjug. Chem., 13, pp. 1176-1180
Kusov, Y. Y., Gauss-Muller, V., In vitro RNA binding of the hepatitis A virus protienase 3C (HAV 3Cpro) to secondary structure elements within the 5 terminus of the HAV genome (1997) RNA, 3, pp. 291-302
Kim, K. H., Hemenway, C., The 5 nontranslated region of potato virus X RNA affects both genomic and subgenomic RNA synthesis (1996) J. Virol., 70, pp. 5533-5540
Richards, O. C., Ehrenfeld, E., Poliovirus RNA replication (1990) Curr. Top. Microbiol. Immunol., 161, pp. 89-119
Wang, Q. M., Protease inhibitors as potential antiviral agents for the treatment of picornaviral infections (2001) Prog. Drug Res., 52 (SPEC. ISSUE), pp. 229-253
Kong, J. S., Venkatraman, S., Furness, K., Nimkar, S., Shepherd, T. A., Wang, Q. M., Aube, J., Hanzlik, R. P., Synthesis and evaluation of peptidyl Michael acceptors that inactivate human rhinovirus 3C protease and inhibit virus replication (1998) J. Med. Chem., 41, pp. 2579-2587
Skripkin, E. A., Jacobson, A. B., A two-dimensional model at the nucleotide level for the central hairpin of coliphage Q RNA (1993) J. Mol. Biol., 233, pp. 245-260
Pace, C. N., Vajdos, F., Fee, L., Grimsley, G., Gray, T., How to measure and predict the molar absorption coefficient of a protein (1995) Protein Sci., 4, pp. 2411-2423
Sosnick, T. R., Fang, X., Shelton, V. M., Application of circular dichroism to study RNA folding transitions (2000) Meth. Enzymol., 317, pp. 393-409
Wang, G., Xu, X. S., Peptide nucleic acid (PNA) binding-mediated gene regulation (2004) Cell Res., 14, pp. 111-116
Targeting regulatory RNA regions to interfere with the biosynthesis of a protein is an intriguing alternative to targeting a protein itself. Regulatory regions are often unique in sequence and/or structure and, thus, ideally suited for specific recognition with a low risk of undesired side effects. Targeting regulatory RNA elements, however, is complicated by their complex three-dimensional structure, which poses kinetic and thermodynamic constraints to the recognition by a complementary oligonucleotide. Oligonucleotide mimics, which shift the thermodynamic equilibrium towards complex formation and yield stable complexes with a target RNA, can overcome this problem. Peptide nucleic acids (PNA) represent such a promising class of molecules. PNA are very stable, non-ionic compounds and they are not sensitive to enzymatic degradation. Yet, PNA form specific base pairs with a target sequence. We have designed, synthesised and characterised PNA able to enter infected cells and to bind specifically to a control region of the genomic RNA of coxsackievirus B3 (CV133), which is an important human pathogen. The results obtained by studying the interaction of such PNA with their RNA target, the entrance into the cell and the viral inhibition are herein presented. Copyright © 2005 European Peptide Society and John Wiley & Sons, Ltd.
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* New G-quadruplex-forming oligodeoxynucleotides incorporating a bifunctional Double-Ended Linker (DEL): effects of DEL size and ODNs orientation on the topology, stability and molecularity of DEL-G-quadruplexes (58 visite)
Molecules (ISSN: 1420-3049linking, 1420-3049electronic), 2019 Feb 12; 24(3): 654-654.
Impact Factor: 3.06
Dettagli Esporta in BibTeX Esporta in EndNote
Camorani S, Fedele M, Zannetti A, Cerchia L
* TNBC Challenge: Oligonucleotide Aptamers for New Imaging and Therapy Modalities (156 visite) (PDF 36 visite)
Pharmaceuticals (ISSN: 1424-8247print, 1424-8247linking), 2018 Nov 13; 11(4): N/D-N/D.
Impact Factor: 0
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Avitabile C, Diaferia C, Della Ventura B, Mercurio FA, Leone M, Roviello V, Saviano M, Velotta R, Morelli G, Accardo A, Romanelli A
* Self-Assembling of Fmoc-GC Peptide Nucleic Acid Dimers into Highly Fluorescent Aggregates (137 visite)
Chemistry (ISSN: 1521-3765electronic, 0947-6539linking), 2018 Mar 26; 24(18): 4729-4735.
Impact Factor: 5.476
Dettagli Esporta in BibTeX Esporta in EndNote
Martinez Fernandez L, Muñoz-losa A, Esposito L, Improta R
* The optical properties of adenine cation in different oligonucleotides: a PCM/TD‑DFT study (46 visite) (PDF 29 visite)
Theor Chem Acc (ISSN: 1432-881x), 2018; 137(3): N/D-N/D.
Impact Factor: 1.545
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Piras L, Avitabile C, D'Andrea LD, Saviano M, Romanelli A
* Detection of oligonucleotides by PNA-peptide conjugates recognizing the biarsenical fluorescein complex FlAsH-EDT2 (115 visite)
Biochem Bioph Res Co (ISSN: 0006-291x), 2017 Sep 15; N/D: N/D-N/D.
Impact Factor: 2.559
Dettagli Esporta in BibTeX Esporta in EndNote
Improta R, Santoro F, Blancafort L
* Quantum Mechanical Studies on the Photophysics and the Photochemistry of Nucleic Acids and Nucleobases (161 visite)
Chem Rev (ISSN: 0009-2665), 2016; 116(6): 3540-3593.
Impact Factor: 47.928
Dettagli Esporta in BibTeX Esporta in EndNote
Roviello GN, Vicidomini C, Di Gaetano S, Capasso D, Musumeci D, Roviello V
* Solid phase synthesis and RNA-binding activity of an arginine-containing nucleopeptide (170 visite)
Rsc Adv (ISSN: 2046-2069), 2016; 6(17): 14140-14148.
Impact Factor: 3.108
Dettagli Esporta in BibTeX Esporta in EndNote
Ringhieri P, Avitabile C, Saviano M, Morelli G, Romanelli A, Accardo A
* The influence of liposomal formulation on the incorporation and retention of PNA oligomers (29 visite)
Colloid Surface B (ISSN: 0927-7765), 2016; 145: 462-469.
Impact Factor: 3.887
Dettagli Esporta in BibTeX Esporta in EndNote
Autiero I, Saviano M, Langella E
* Conformational studies of chiral D-Lys-PNA and achiral PNA system in binding with DNA or RNA through a molecular dynamics approach (212 visite)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2015 Feb 16; 91: 109-117.
Impact Factor: 3.902
Dettagli Esporta in BibTeX Esporta in EndNote
Avitabile C, D'Andrea LD, Romanelli A
* Exploring the dark matter of the human genome using oligonucleotide-based molecules (82 visite)
Future Med Chem (ISSN: 1756-8919, 1756-8919linking, 1756-8927electronic), 2015; 7(13): 1627-1630.
Impact Factor: 3.345
Dettagli Esporta in BibTeX Esporta in EndNote
Avitabile C, Accardo A, Ringhieri P, Morelli G, Saviano M, Montagner G, Fabbri E, Gallerani E, Gambari R, Romanelli A
* Incorporation of Naked Peptide Nucleic Acids into Liposomes Leads to Fast and Efficient Delivery (136 visite)
Bioconjug Chem (ISSN: 1043-1802, 1520-4812), 2015; 26(8): 1533-1541.
Impact Factor: 4.5
Dettagli Esporta in BibTeX Esporta in EndNote
Musumeci D, Rozza L, Merlino A, Paduano L, Marzo T, Massai L, Messori L, Montesarchio D
* Interaction of anticancer Ru(III) complexes with single stranded and duplex DNA model systems (171 visite)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9226linking), 2015; 44(31): 13914-13925.
Impact Factor: 4.177
Dettagli Esporta in BibTeX Esporta in EndNote
Zhang Y, Dood J, Beckstead AA, Li X-B, Nguyen KV, Burrows CJ, Improta R, Kohler B
* Efficient UV-induced charge separation and recombination in an 8-oxoguanine-containing dinucleotide (149 visite)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2014 Sep 12; 111(32): 11612-11617.
Impact Factor: 9.674
Dettagli Esporta in BibTeX Esporta in EndNote
Musumeci D, Roviello GN, Montesarchio D
* An overview on HMGB1 inhibitors as potential therapeutic agents in HMGB1-related pathologies (204 visite)
Pharmacol Therapeut (ISSN: 0163-7258), 2014 Mar; 141(3): 347-357.
Impact Factor: 9.723
Dettagli Esporta in BibTeX Esporta in EndNote
Romanucci V, Milardi D, Campagna T, Gaglione M, Messere A, D'Urso A, Crisafi E, La Rosa C, Zarrelli A, Balzarini J, Di Fabio G
* Synthesis, biophysical characterization and anti-HIV activity of d(TG(3)AG) Quadruplexes bearing hydrophobic tails at the 5 '-end (187 visite)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391), 2014 Feb 1; 22(3): 960-966.
Impact Factor: 2.793
Dettagli Esporta in BibTeX Esporta in EndNote
Russo Krauss I, Parkinson GN, Merlino A, Mattia CA, Randazzo A, Novellino E, Mazzarella L, Sica F
* A regular thymine tetrad and a peculiar supramolecular assembly in the first crystal structure of an all-LNA G-quadruplex (147 visite)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2014 Feb; 70(2): 362-370.
Impact Factor: 7.232
Dettagli Esporta in BibTeX Esporta in EndNote
Autiero I, Saviano M, Langella E
* Molecular Dynamics Simulations Of Pna-Pna And Pna-Dna Duplexes By The Use Of New Parameters Implemented In The Gromacs Package: A Conformational And Dynamics Study (189 visite)
Phys Chem Chem Phys (ISSN: 1463-9076, 1463-3907, 1463-9084electronic), 2014; 16(5): 1868-1874.
Impact Factor: 4.493
Dettagli Esporta in BibTeX Esporta in EndNote
Malgieri G, Palmieri M, Esposito S, Maione V, Russo L, Baglivo I, De Paola I, Milardi D, Diana D, Zaccaro L, Pedone PV, Fattorusso R, Isernia C
* Zinc To Cadmium Replacement In The Prokaryotic Zinc-Finger Domain (205 visite)
Metallomics (ISSN: 1756-591x, 1756-5901, 1756-591xelectronic), 2013 Dec 18; 6(1): 96-104.
Impact Factor: 3.978
Dettagli Esporta in BibTeX Esporta in EndNote
Roviello GN, Musumeci D, D'Alessandro C, Pedone C
* Synthesis of a thymine-functionalized nucleoamino acid for the solid phase assembly of cationic nucleopeptides (231 visite)
Amino Acids (ISSN: 1438-2199, 0939-4451, 1438-2199electronic), 2013 Oct; 45(4): 779-784.
Impact Factor: 3.653
Dettagli Esporta in BibTeX Esporta in EndNote
Zanoli LM, Licciardello M, D'Agata R, Lantano C, Calabretta A, Corradini R, Marchelli R, Spoto G
* Peptide nucleic acid molecular beacons for the detection of PCR amplicons in droplet-based microfluidic devices (117 visite)
Anal Bioanal Chem (ISSN: 1618-2642), 2013 Jan; 405(2-3): 615-624.
Impact Factor: 3.578
Dettagli Esporta in BibTeX Esporta in EndNote
Roviello GN, Musumeci D, Bucci EM, Pedone C
* Synthesis of a diaminopropanoic acid-based nucleoamino acid and assembly of cationic nucleopeptides for biomedical applications (203 visite)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2012 Dec; 43(6): 2537-2543.
Impact Factor: 3.914
Dettagli Esporta in BibTeX Esporta in EndNote
Roviello GN, Roviello G, Musumeci D, Bucci EM, Pedone C
* Dakin-West reaction on 1-thyminyl acetic acid for the synthesis of 1, 3-bis(1-thyminyl)-2-propanone, a heteroaromatic compound with nucleopeptide-binding properties (162 visite)
Amino Acids (ISSN: 1438-2199, 0939-4451, 1438-2199electronic), 2012 Oct; 43(4): 1615-1623.
Impact Factor: 3.914
Dettagli Esporta in BibTeX Esporta in EndNote
Avitabile C, Moggio L, Malgieri G, Capasso D, Di Gaetano S, Saviano M, Pedone C, Romanelli A
* Gamma Sulphate Pna (pna S): Highly Selective Dna Binding Molecule Showing Promising Antigene Activity (169 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2012 May 7; 7(5): e35774-e35774.
Impact Factor: 3.73
Dettagli Esporta in BibTeX Esporta in EndNote
D'Agata R, Spoto G
* Artificial DNA and surface plasmon resonance (275 visite)
Artificial Dna Pna & Xna (ISSN: 1949-095x), 2012 Apr; 3(2): N/D-N/D.
Impact Factor: 0
Dettagli Esporta in BibTeX Esporta in EndNote
Avitabile C, Saviano M, D'Andrea LD, Bianchi N, Fabbri E, Brognara E, Gambari R, Romanelli A
* Targeting pre-miRNA by peptide nucleic acids: a new strategy to interfere in the miRNA maturation (204 visite)
Artif Dna Pna Xnaartificial Dna Pna & Xna (ISSN: 1949-9096, 1949-0968, 1949-095x), 2012 Apr; 3(2): 88-96.
Impact Factor: 0
Dettagli Esporta in BibTeX Esporta in EndNote
Musumeci D, Oliviero G, Roviello GN, Bucci EM, Piccialli G
* G-quadruplex-forming oligonucleotide conjugated to magnetic nanoparticles: Synthesis, characterization, and enzymatic stability assays (188 visite)
Bioconjug Chem (ISSN: 1043-1802, 1520-4812, 1520-4812electronic), 2012 Mar 21; 23(3): 382-391.
Impact Factor: 4.58
Dettagli Esporta in BibTeX Esporta in EndNote
Improta R, Barone V
* Interplay between "neutral" and "charge-transfer" excimers rules the excited state decay in adenine-rich polynucleotides (99 visite)
Angew Chem Int Ed (ISSN: 1433-7851, 1521-3773electronic), 2011 Dec 9; 50(50): 12016-12019.
Impact Factor: 13.455
Dettagli Esporta in BibTeX Esporta in EndNote
Roviello GN, Musumeci D, Bucci EM, Pedone C
* Synthesis and characterization of a novel ester-based nucleoamino acid for the assembly of aromatic nucleopeptides for biomedical applications (266 visite)
Int J Pharm (ISSN: 0378-5173, 1873-3476), 2011 Sep 30; 415(1-2): 206-210.
Impact Factor: 3.35
Dettagli Esporta in BibTeX Esporta in EndNote
Musumeci D, Bucci EM, Roviello GN, Sapio R, Valente M, Moccia M, Bianchi ME, Pedone C
* DNA-based strategies for blocking HMGB1 cytokine activity: Design, synthesis and preliminary in vitro/in vivo assays of DNA and DNA-like duplexes (179 visite)
Mol Biosyst (ISSN: 1742-206x, 1742-2051, 1742-2051electronic), 2011 May; 7(5): 1742-1752.
Impact Factor: 3.534
Dettagli Esporta in BibTeX Esporta in EndNote
Roviello GN, Ricci A, Bucci EM, Pedone C
* Synthesis, biological evaluation and supramolecular assembly of novel analogues of peptidyl nucleosides (507 visite)
Mol Biosyst (ISSN: 1742-206x, 1742-2051, 1742-2051electronic), 2011 May; 7(5): 1773-1778.
Impact Factor: 3.534
Dettagli Esporta in BibTeX Esporta in EndNote
Roviello GN, Musumeci D, Bucci EM, Pedone C
* Evidences for supramolecular organization of nucleopeptides: Synthesis, spectroscopic and biological studies of a novel dithymine l-serine tetrapeptide (202 visite)
Mol Biosyst (ISSN: 1742-206x, 1742-2051, 1742-2051electronic), 2011 Apr; 7(4): 1073-1080.
Impact Factor: 3.534
Dettagli Esporta in BibTeX Esporta in EndNote
D'Auria G, Esposito C, Falcigno L, Calvanese L, Iaccarino E, Ruggiero A, Pedone C, Pedone E, Berisio R
* Dynamical properties of cold shock protein A from Mycobacterium tuberculosis (135 visite)
Biochem Biophys Res Commun (ISSN: 0006-291x, 1090-2104, 1090-2104electronic), 2010 Nov 26; 402(4): 693-698.
Impact Factor: 2.595
Dettagli Esporta in BibTeX Esporta in EndNote
Pensato S, Saviano M, Bianchi N, Borgatti M, Fabbri E, Gambari R, Romanelli A
* Gamma-Hydroxymethyl Pnas: Synthesis, Interaction With Dna And Inhibition Of Protein/Dna Interactions (159 visite)
Bioorg Chem, 2010 Sep; 38(5): 196-201.
Impact Factor: 2.141
Dettagli Esporta in BibTeX Esporta in EndNote
Roviello GN, Crescenzo C, Capasso D, Di Gaetano S, Franco S, Bucci EM, Pedone C
* Synthesis of a novel Fmoc-protected nucleoaminoacid for the solid phase assembly of 4-piperidyl glycine/L-arginine-containing nucleopeptides and preliminary RNA interaction studies (201 visite)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 Sep; 39(3): 795-800.
Impact Factor: 4.106
Dettagli Esporta in BibTeX Esporta in EndNote
Russo Krauss I, Merlino A, Randazzo A, Mazzarella L, Sica F
* Crystallization and preliminary X-ray analysis of the complex of human alpha-thrombin with a modified thrombin-binding aptamer (164 visite)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309, 1532-2335electronic), 2010 Aug 1; 66(Pt8): 961-963.
Impact Factor: 0.563
Dettagli Esporta in BibTeX Esporta in EndNote
Avitabile C, Moggio L, D'Andrea LD, Pedone C, Romanelli A
* Development of an efficient and low-cost protocol for the manual PNA synthesis by Fmoc chemistry (172 visite)
Tetrahedron Lett (ISSN: 0040-4039), 2010 Jul 21; 51(29): 3716-3718.
Impact Factor: 2.618
Dettagli Esporta in BibTeX Esporta in EndNote
D'Agata R, Corradini R, Ferretti C, Zanoli L, Gatti M, Marchelli R, Spoto G
* Ultrasensitive detection of non-amplified genomic DNA (204 visite)
Lect Notes Electr Eng, 2010 May 15; 91LNEE: 485-488.
Impact Factor: 0
Dettagli Esporta in BibTeX Esporta in EndNote
D'Agata R, Corradini R, Ferretti C, Zanoli L, Gatti M, Marchelli R, Spoto G
* Ultrasensitive detection of non-amplified genomic DNA by nanoparticle-enhanced surface plasmon resonance imaging (139 visite)
Biosens Bioelectron (ISSN: 0956-5663, 1873-4235electronic), 2010 May 15; 25(9): 2095-2100.
Impact Factor: 5.361
Dettagli Esporta in BibTeX Esporta in EndNote
Pensato S, Renda M, Leccia F, Saviano M, D'Andrea LD, Pedone C, Pedone PV, Romanelli A
* PNA zipper as a dimerization tool: development of a bZip mimic (205 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2010 May; 93(5): 434-441.
Impact Factor: 2.572
Dettagli Esporta in BibTeX Esporta in EndNote
Roviello GN, Gröschel S, Pedone C, Diederichsen U
* Synthesis of novel MMT/acyl-protected nucleo alanine monomers for the preparation of DNA/alanyl-PNA chimeras (159 visite)
Amino Acids (ISSN: 1438-2199, 0939-4451, 1438-2199electronic), 2010 May; 38(5): 1301-1309.
Impact Factor: 4.106
Dettagli Esporta in BibTeX Esporta in EndNote
Roviello GN, Di Gaetano S, Capasso D, Cesarani A, Bucci EM, Pedone C
* Synthesis, spectroscopic studies and biological activity of a novel nucleopeptide with Moloney murine leukemia virus reverse transcriptase inhibitory activity (176 visite)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 May; 38(5): 1489-1496.
Impact Factor: 4.106
Dettagli Esporta in BibTeX Esporta in EndNote
Roviello GN, Musumeci D, Pedone C, Bucci EM
* Synthesis, Characterization And Hybridization Studies Of An Alternate Nucleo-Epsilon/Gamma-Peptide: Complexes Formation With Natural Nucleic Acids (180 visite)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 Jan; 38(1): 103-111.
Impact Factor: 4.106
Dettagli Esporta in BibTeX Esporta in EndNote
D'Agata R, Breveglieri G, Zanoli L, Borgatti M, Spoto G, Gambari R
* Surface Plasmon Resonance Imaging (SPR-I), peptide nucleic acid (PNA) probes and nanoparticle-enhancement for PCR-free ultrasensitive detection of beta-thalassemia mutations in human genomic DNA (129 visite)
International Journal Of Molecular Medicine (ISSN: 1107-3756), 2010; 26: N/D-N/D.
Impact Factor: 1.814
Dettagli Esporta in BibTeX Esporta in EndNote
Moccia M, Musumeci D, Roviello GN, Fusco S, Valente M, Bucci EM, Sapio R, Pedonea C, Netti PA
* Preliminary studies on noncovalent hyperbranched polymers based on PNA and DNA building blocks (247 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Oct; 15(10): 647-653.
Impact Factor: 1.807
Dettagli Esporta in BibTeX Esporta in EndNote
Roviello GN, Musumeci D, Moccia M, Castiglione M, Cesarani A, Bucci EM, Saviano M, Pedone C, Benedetti E
* Evidences Of Complex Formation Between Daba-Based Nucleo-Gamma-Peptides With Alternate Configuration Backbone (213 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 147-154.
Impact Factor: 1.807
Dettagli Esporta in BibTeX Esporta in EndNote
Roviello GN, Musumeci D, Castiglione M, Bucci EM, Pedone C, Benedetti E
* Solid Phase Synthesis And Rna-Binding Studies Of A Serum-Resistant Nucleo-Epsilon-Peptide (171 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 155-160.
Impact Factor: 1.807
Dettagli Esporta in BibTeX Esporta in EndNote
Roviello GN, Musumeci D, Bucci EM, Castiglione M, Cesarani A, Pedone C, Piccialli G
* Evidences for complex formation between l-dabPNA and aegPNA (136 visite)
Bioorg Med Chem Lett (ISSN: 0960-894x, 1464-3405, 1464-3405electronic), 2008 Sep 1; 18(17): 4757-4760.
Impact Factor: 2.531
Dettagli Esporta in BibTeX Esporta in EndNote
D'Agata R, Corradini R, Grasso G, Marchelli R, Spoto G
* Ultrasensitive detection of DNA by PNA and nanoparticle-enhanced surface plasmon resonance imaging (206 visite)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2008 Sep 1; 9(13): 2067-2070.
Impact Factor: 3.322
Dettagli Esporta in BibTeX Esporta in EndNote
Prato S, Vitale RM, Contursi P, Lipps G, Saviano M, Rossi M, Bartolucci S
* Molecular modeling and functional characterization of the monomeric primase-polymerase domain from the Sulfolobus solfataricus plasmid pIT3 (167 visite)
Febs J (ISSN: 1742-464x), 2008; 275(17): 4389-4402.
Impact Factor: 3.139
Dettagli Esporta in BibTeX Esporta in EndNote
Pensato S, D'Andrea LD, Pedone C, Romanelli A
* New synthetic route to gamma-mercaptomethyl PNA monomers (160 visite)
Synth Commun Synthetic Communications (ISSN: 0039-7911), 2008; 38(15): 2499-2506.
Impact Factor: 0.981
Dettagli Esporta in BibTeX Esporta in EndNote
Breveglieri G, Pensato S, Salvatori F, Saviano M, Pedone C, Romanelli A, Gambari R
* PNA-mediated alteration of mRNA splicing (136 visite)
Minerva Biotecnol (ISSN: 1120-4826), 2008; 20(4): 175-181.
Impact Factor: 0.1
Dettagli Esporta in BibTeX Esporta in EndNote
Marchelli R, Saviano M, Licandro E, Spoto G, Borgatti M, Gambari R
* PNAs targeting the "RNA world": Micro RNA next? (160 visite)
Minerva Biotecnol (ISSN: 1120-4826), 2008; 20(4): 183-188.
Impact Factor: 0.1
Dettagli Esporta in BibTeX Esporta in EndNote
Zanoli L, Dagata R, Spoto G
* Surface plasmon-based optical detection of DNA peptide nucleic acids (144 visite)
Minerva Biotecnol (ISSN: 1120-4826), 2008; 20(4): 165-174.
Impact Factor: 0.1
Dettagli Esporta in BibTeX Esporta in EndNote
Pensato S, Saviano M, Romanelli A
* New peptide nucleic acid analogues: synthesis and applications (194 visite)
Expert Opinion On Biological Therapy (ISSN: 1471-2598), 2007 Sep; 7(8): 1219-1232.
Impact Factor: 2.815
Dettagli Esporta in BibTeX Esporta in EndNote
Musumeci D, Roviello GN, Moccia M, Pedone C, Bucci EM, Sapio R, Valente M, Fumero S
* Bent oligonucleotide duplexes as HMGB1 inhibitors: A comparative study (197 visite)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1525-7770), 2007; 26(10-12): 1447-1450.
Impact Factor: 0.723
Dettagli Esporta in BibTeX Esporta in EndNote
Roviello GN, Musumeci D, Moccia M, Castiglione M, Sapio R, Valente M, Bucci EM, Perretta G, Pedone C
* Dabpna: Design, Synthesis And Nucleic Acids Binding Studies (179 visite)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1525-7770), 2007; 26(10-12): 1307-1310.
Impact Factor: 0.723
Dettagli Esporta in BibTeX Esporta in EndNote
Bucci EM, Valente M, Musumeci D, Sapio R, Anrò V, Roviello GN, Moccia M
* ODN-based drugs for targeting of extracellular proteins (136 visite)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1525-7770), 2007; 26(8-9): 1047-1050.
Impact Factor: 0.723
Dettagli Esporta in BibTeX Esporta in EndNote
Moccia M, Musumeci D, Valente M, Roviello GN, Sapio R, Pedone C, Bucci EM
* Thermodynamic studies on PNA and PNA/DNA dendrimer formation (112 visite)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1525-7770), 2007; 26(8-9): 1173-1176.
Impact Factor: 0.723
Dettagli Esporta in BibTeX Esporta in EndNote
Roviello GN, Moccia M, Sapio R, Valente M, Bucci EM, Castiglione M, Pedone C, Perretta G, Benedetti E, Musumeci D
* Synthesis, Characterization And Hybridization Studies Of New Nucleo-Gamma-Peptides Based On Diaminobutyric Acid (199 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Dec; 12(12): 829-835.
Impact Factor: 1.801
Dettagli Esporta in BibTeX Esporta in EndNote
Zannetti A, Del Vecchio S, Romanelli A, Scala S, Saviano M, Cali' G, Stoppelli MP, Pedone C, Salvatore M
* Inhibition of Sp1 activity by a decoy PNA-DNA chimera prevents urokinase receptor expression and migration of breast cancer cells (241 visite)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 0006-2952, 1873-2968), 2005 Nov 1; 70(9): 1277-1287.
Impact Factor: 3.617
Dettagli Esporta in BibTeX Esporta in EndNote
Borgatti M, Boyd DD, Lampronti I, Bianchi N, Fabbri E, Saviano M, Romanelli A, Pedone C, Gambari R
* Decoy molecules based on PNA-DNA chimeras and targeting Sp1 transcription factors inhibit the activity of urokinase-type plasminogen activator receptor (uPAR) promoter (167 visite)
Oncology Research (ISSN: 0965-0407), 2005; 15(7-8): 373-383.
Impact Factor: 1.844
Dettagli Esporta in BibTeX Esporta in EndNote
Borgatti M, Finotti A, Romanelli A, Saviano M, Bianchi N, Lampronti I, Lambertini E, Penolazzi L, Nastruzzi C, Mischiati C, Piva R, Pedone C, Gambari R
* Peptide nucleic acids (PNA)-DNA chimeras targeting transcription factors as a tool to modify gene expression (163 visite)
Curr Drug Targets (ISSN: 1389-4501), 2004 Nov; 5(8): 735-744.
Impact Factor: 4.104
Dettagli Esporta in BibTeX Esporta in EndNote
Mischiati C, Sereni A, Finotti A, Breda L, Cortesi R, Nastruzzi C, Romanelli A, Saviano M, Bianchi N, Pedone C, Borgatti M, Gambari R
* Complexation to cationic microspheres of double-stranded peptide nucleic acid-DNA chimeras exhibiting decoy activity (131 visite)
Journal Of Biomedical Science (ISSN: 1021-7770), 2004 Sep; 11(5): 697-704.
Impact Factor: 1.567
Dettagli Esporta in BibTeX Esporta in EndNote
Penolazzi L, Borgatti M, Lambertini E, Mischiati C, Finotti A, Romanelli A, Saviano M, Pedone C, Piva R, Gambari R
* Peptide nucleic acid-DNA decoy chimeras targeting NF-kappa B transcription factors: Induction of apoptosis in human primary osteoclasts (153 visite)
International Journal Of Molecular Medicine (ISSN: 1107-3756), 2004 Sep; 14(2): 145-152.
Impact Factor: 3.19
Dettagli Esporta in BibTeX Esporta in EndNote
Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F
* Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (235 visite)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2004 Jun 30; 24(26): 6021-6027.
Impact Factor: 2.384
Dettagli Esporta in BibTeX Esporta in EndNote
Cortesi R, Mischiati C, Borgatti M, Breda L, Romanelli A, Saviano M, Pedone C, Gambari R, Nastruzzi C
* Formulations for natural and peptide nucleic acids based on cationic polymeric submicron particles (188 visite)
The Aaps Journal (ISSN: 1522-1059, 1550-7416), 2004 Jan 20; 6(1): N/D-N/D.
Impact Factor: 1.938
Dettagli Esporta in BibTeX Esporta in EndNote
Musumeci D, Roviello GN, Valente M, Sapio R, Pedone C, Bucci EM
* New synthesis of PNA-3′DNA linker monomers, useful building blocks to obtain PNA/DNA chimeras (163 visite)
Biopolymers, 2004; 76(6): 535-542.
Impact Factor: 2.248
Dettagli Esporta in BibTeX Esporta in EndNote
Ohlenschlager O, Wohnert J, Bucci E, Seitz S, Hafner S, Ramachandran R, Zell R, Gorlach M
* The Structure of the Stemloop D Subdomain of Coxsackievirus B3 Cloverleaf RNA and Its Interaction with the Proteinase 3C (161 visite)
Structure (ISSN: 0969-2126, 1878-4186), 2004; 12(2): 237-248.
Impact Factor: 5.185
Dettagli Esporta in BibTeX Esporta in EndNote
Menchise V, De Simone G, Tedeschi T, Corradini R, Sforza S, Marchelli R, Capasso D, Saviano M, Pedone C
* Insights into peptide nucleic acid (PNA) structural features: The crystal structure of a D-lysine-based chiral PNA-DNA duplex (219 visite)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2003 Oct 14; 100(21): 12021-12026.
Impact Factor: 10.272
Dettagli Esporta in BibTeX Esporta in EndNote
Borgatti M, Lampronti I, Romanelli A, Pedone C, Saviano M, Bianchi N, Mischiati C, Gambari R
* Transcription factor decoy molecules based on a peptide nucleic acid (PNA)-DNA chimera mimicking Sp1 binding sites (179 visite)
J Biol Chem (ISSN: 0021-9258, 1083-351x), 2003 Feb 28; 278(9): 7500-7509.
Impact Factor: 6.482
Dettagli Esporta in BibTeX Esporta in EndNote
Borgatti M, Romanelli A, Saviano M, Pedone C, Lampronti I, Breda L, Nastruzzi C, Bianchi N, Mischiati C, Gambari R
* Resistance of decoy PNA-DNA chimeras to enzymatic degradation in cellular extracts and serum (121 visite)
Oncology Research (ISSN: 0965-0407), 2003; 13(5): 279-287.
Impact Factor: 1.794
Dettagli Esporta in BibTeX Esporta in EndNote
Gambari R, Borgatti M, Romanelli A, Capasso D, Saviano M, Bianchi N, Lampronti I, Mischiati C, Pedone C
* Transcription factor decoy (TFD) activity of peptide nucleic acids (PNA)-DNA chimeras (124 visite)
International Journal Of Molecular Medicine (ISSN: 1107-3756), 2003; 12(Supplement1): N/D-N/D.
Impact Factor: 1.94
Dettagli Esporta in BibTeX Esporta in EndNote
Borgatti M, Breda L, Cortesi R, Nastruzzi C, Romanelli A, Saviano M, Bianchi N, Mischiati C, Pedone C, Gambari R
* Cationic Liposomes As Delivery Systems For Double-Stranded Pna-Dna Chimeras Exhibiting Decoy Activity Against Nf-Kappab Transcription Factors (130 visite)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 1873-2968, 0006-2952), 2002 Sep 15; 64(4): 609-616.
Impact Factor: 3.542
Dettagli Esporta in BibTeX Esporta in EndNote
Menchise V, De Simone G, Corradini R, Sforza S, Sorrentino N, Romanelli A, Saviano M, Pedone C
* Crystallization and preliminary X-ray diffraction studies of a D-lysine-based chiral PNA-DNA duplex (133 visite)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2002 Mar; 58(3): 553-555.
Impact Factor: 1.76
Dettagli Esporta in BibTeX Esporta in EndNote
Zell R, Sidigi K, Bucci E, Stelzner A, Goerlach M
* Determinants of the recognition of enteroviral cloverleaf RNA by coxsackievirus B3 proteinase 3C (156 visite)
Rna (ISSN: 1355-8382), 2002; 8(2): 188-201.
Impact Factor: 5.099
Dettagli Esporta in BibTeX Esporta in EndNote
Romanelli A, Pedone C, Saviano M, Bianchi N, Borgatti M, Mischiati C, Gambari R
* Molecular interactions between nuclear factor κB (NF-κB) transcription factors and a PNA-DNA chimera mimicking NF-κB binding sites (143 visite)
Eur J Biochem (ISSN: 0014-2956, 0014-2956print, 0014-2956linking), 2001 Dec; 268(23): 6066-6075.
Impact Factor: 2.849
Dettagli Esporta in BibTeX Esporta in EndNote
Romanelli A, Pedone C, Saviano M, Bianchi N, Borgatti M, Mischiati C, Gambari R
* Molecular interactions with nuclear factor kappaB (NF-kappaB) transcription factors of a PNA-DNA chimera mimicking NF-kappaB binding sites (122 visite)
Eur J Biochem (ISSN: 0014-2956print, 0014-2956linking), 2001 Dec; 268(23): 6066-6075.
Impact Factor: 4.779
Dettagli Esporta in BibTeX Esporta in EndNote
Saviano M, Romanelli A, Bucci E, Pedone C, Mischiati C, Bianchi N, Feriotto G, Borgatti M, Gambari R
Computational procedures to explain the different biological activity of DNA/DNA, DNA/PNA and PNA/PNA hybrid molecules mimicking NF-κB binding sites (131 visite)
J Biomol Struct Dyn (ISSN: 0739-1102, 1538-0254electronic), 2000 Dec; 18(3): 353-362.
Impact Factor: 1.826
Dettagli Esporta in BibTeX Esporta in EndNote
Zannetti A, Del Vecchio S, Carriero MV, Fonti R, Franco P, Botti G, D'Aiuto G, Stoppelli MP, Salvatore M
Coordinate up-regulation of Sp1 DNA-binding activity and urokinase receptor expression in breast carcinoma (208 visite)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 2000 Mar 15; 60(6): 1546-1551.
Impact Factor: 8.46
Dettagli Esporta in BibTeX Esporta in EndNote
De Napoli L, De Luca S, Di Fabio G, Messere A, Montesarchio D, Morelli G, Piccialli G, Tesauro D
A facile solid-phase strategy for the synthesis of oligonucleotide- tetraphenylporphyrin conjugates (124 visite)
European Journal Of Organic Chemistry (ISSN: 1434-193x), 2000; (6): 1013-1018.
Impact Factor: 2.15
Dettagli Esporta in BibTeX Esporta in EndNote
Romanelli A, De Napoli L, Messere A, Montesarchio D, Piccialli G, Zaccaro L, Pedone C, Rossi F, Benedetti E
Fully automated synthesis of peptide-oligonucleotide conjugates (162 visite)
Peptides For The New Millennium, 2000; N/D: N/D-N/D.
Impact Factor: 2.614
Dettagli Esporta in BibTeX Esporta in EndNote
82 Records (75 escludendo Abstract e Conferenze).
Impact factor totale: 312.99 (300.391 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 332.282 (316.316 escludendo Abstract e Conferenze).
Impact factor totale: 312.99 (300.391 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 332.282 (316.316 escludendo Abstract e Conferenze).
Esporta in BibTeX Esporta in EndNote
Ultima modifica di Marco Comerci in data Friday 26 May 2017, 11:20:53
126 visite. Ultima visita in data Friday 29 November 2019, 2:22:28
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