Inhibition of Sp1 activity by a decoy PNA-DNA chimera prevents urokinase receptor expression and migration of breast cancer cells (256 visite)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 0006-2952, 1873-2968), 2005 Nov 1; 70(9): 1277-1287.
Tipo di articolo: Journal Article,
Impact factor: 3.617, Impact factor a 5 anni: 4.772
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-25644442324&partnerID=40&md5=ee6ad4844b2546aad2114f23c7770227
Parole chiave: Breast Cancer, Peptide Nucleic Acid, Pna-Dna Chimera, Sp1 Transcription Factor, Urokinase Receptor, Complementary Dna, Liposome, Oligonucleotide, Transcription Factor Sp1, Amino Acid Sequence, Article, Cancer Cell, Cancer Inhibition, Cell Migration, Cell Motility, Covalent Bond, Dna Strand, Down Regulation, Genetic Transfection, Human, Human Cell, In Vitro Study, Inhibition Kinetics, Metastasis, Priority Journal, Protein Binding, Protein Expression, Protein Function, Receptor Upregulation, Breast Neoplasms, Cell Line, Tumor, Cell Movement, Female, Cell Surface,
Affiliazioni:
*** IBB - CNR ***
Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale Delle Ricerche, Via S. Pansini 5, 80131 Naples, Italy
Istituto di Endocrinologia Ed Oncologia Sperimentale, Consiglio Nazionale Delle Ricerche, Naples, Italy
Istituto Internazionale di Genetica e Biofisica, Consiglio Nazionale Delle Ricerche, Naples, Italy
Dipartimento di Scienze Biomorfologiche e Funzionali, Universita' Federico II, Naples, Italy
Riferimenti:
Chambers, A.F., Groom, A.C., MacDonald, I.C., Dissemination and growth of cancer cells in metastatic sites (2002) Nat Rev Cancer, 2, pp. 563-57
Andreasen, P.A., Egelund, R., Petersen, H.H., The plasminogen activation system in tumor growth, invasion, and metastasis (2000) Cell Mol Life Sci, 57, pp. 25-40
Blasi, F., Carmeliet, P., UPAR: A versatile signalling orchestrator (2002) Nat Rev Mol Cell Biol, 3, pp. 932-943
Ossowski, L., Aguirre-Ghiso, J.A., Urokinase receptor and integrin partnership: Coordination of signaling for cell adhesion, migration and growth (2000) Curr Opin Cell Biol, 12, pp. 613-620
Harbeck, N., Kates, R.E., Look, M.P., Meijer-Van Gelder, M.E., Klijn, J.G., Kruger, A., Enhanced benefit from adjuvant chemotherapy in breast cancer patients classified high-risk according to urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor type 1 (n = 3424) (2002) Cancer Res, 62, pp. 4617-4622
Look, M.P., Van Putten, W.L., Duffy, M.J., Harbeck, N., Christensen, I.J., Thomssen, C., Pooled analysis of prognostic impact of urokinase-type plasminogen activator and its inhibitor PAI-1 in 8377 breast cancer patients (2002) J Natl Cancer Inst, 94, pp. 116-128
Fuchs, T., Allgayer, H., Transcriptional regulation of the urokinase receptor (u-PAR) - A central molecule of invasion and metastasis (2003) Biol Chem, 384, pp. 755-761
Soravia, E., Grebe, A., De Luca, P., Helin, K., Suh, T.T., Degen, J.L., A conserved TATA-less proximal promoter drives basal transcription from the urokinase-type plasminogen activator receptor gene (1995) Blood, 86, pp. 624-635
Allgayer, H., Wang, H., Gallick, G.E., Crabtree, A., Mazar, A., Jones, T., Transcriptional induction of the urokinase receptor gene by a constitutively active Src. Requirement of an upstream motif (-152/-135) bound with Sp1 (1999) J Biol Chem, 274, pp. 18428-18437
Black, A.R., Black, J.D., Azizkhan-Clifford, J., Sp1 and kruppel-like factor family of transcription factors in cell growth regulation and cancer (2001) J Cell Physiol, 188, pp. 143-160
Samson, S.L., Wong, N.C., Role of Sp1 in insulin regulation of gene expression (2002) J Mol Endocrinol, 29, pp. 265-729
Bouwman, P., Philipsen, S., Regulation of the activity of Sp1-related transcription factors (2002) Mol Cell Endocrinol, 195, pp. 27-38
Borellini, F., He, Y.F., Aquino, A., Yu, G., Josephs, S.F., Glazer, R.I., Increased DNA binding and transcriptional activity associated with transcription factor Sp1 in K562 cells transfected with the myeloid-specific c-fes tyrosine kinase gene (1991) J Biol Chem, 266, pp. 15850-15854
Kim, S.J., Onwuta, U.S., Lee, Y.I., Li, R., Botchan, M.R., Robbins, P.D., The retinoblastoma gene product regulates Sp1-mediated transcription (1992) Mol Cell Biol, 12, pp. 2455-2463
Sif, S., Capobianco, A.J., Gilmore, T.D., The v-Rel oncoprotein increases expression from Sp1 site-containing promoters in chicken embryo fibroblasts (1993) Oncogene, 8, pp. 2501-2509
Zannetti, A., Del Vecchio, S., Carriero, M.V., Fonti, R., Franco, P., Botti, G., Coordinate up-regulation of Sp1 DNA-binding activity and urokinase receptor expression in breast carcinoma (2000) Cancer Res, 60, pp. 1546-1551
Schewe, D.M., Leupold, J.H., Boyd, D.D., Lengyel, E.R., Wang, H., Gruetzner, K.U., Tumor-specific transcription factor binding to an activator protein-2/Sp1 element of the urokinase-type plasminogen activator receptor promoter in a first large series of resected gastrointestinal cancers (2003) Clin Cancer Res, 9, pp. 2267-2276
Ibanez-Tallon, I., Ferrai, C., Longobardi, E., Facetti, I., Blasi, F., Crippa, M.P., Binding of Sp1 to the proximal promoter links constitutive expression of the human uPA gene and invasive potential of PC3 cells (2002) Blood, 100, pp. 3325-3332
Benasciutti, E., Pages, G., Kenzior, O., Folk, W., Blasi, F., Crippa, M.P., MAPK and JNK transduction pathways can phosphorylate Sp1 to activate the uPA minimal promoter elements and endogenous gene transcription (2004) Blood, 104, pp. 256-262
Ray, A., Norden, B., Peptide nucleic acid (PNA): Its medical and biotechnical applications and promise for the future (2000) Faseb J, 14, pp. 1041-1060
Romanelli, A., Saviano, M., Pedone, C., Synthetic strategies for obtaining PNA and PNA conjugates (2004) Recent Res Dev Org Chem, 8, pp. 237-254
Dignam, J.D., Lebovitz, R.M., Roeder, R.G., Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei (1983) Nucleic Acids Res, 11, pp. 1475-1489
Darnell Jr., J.E., Transcription factors as targets for cancer therapy (2002) Nat Rev Cancer, 2, pp. 740-749
Mann, M.J., Dzau, V.J., Therapeutic applications of transcription factor decoy oligonucleotides (2000) J Clin Invest, 106, pp. 1071-1075
Cho, Y.S., Kim, M.K., Cheadle, C., Neary, C., Park, Y.G., Becker, K.G., A genomic-scale view of the cAMP response element-enhancer decoy: A tumor target-based genetic tool (2002) Proc Natl Acad Sci USA, 99, pp. 15626-15631
Morishita, R., Tomita, N., Kaneda, Y., Ogihara, T., Molecular therapy to inhibit NFkappaB activation by transcription factor decoy oligonucleotides (2004) Curr Opin Pharmacol, 4, pp. 139-146
Penolazzi, L., Lambertini, E., Borgatti, M., Piva, R., Cozzani, M., Giovannini, I., Decoy oligodeoxynucleotides targeting NF-kappaB transcription factors: Induction of apoptosis in human primary osteoclasts (2003) Biochem Pharmacol, 66, pp. 1189-1198
Wang, L.H., Yang, X.Y., Zhang, X., Mihalic, K., Xiao, W., Farrar, W.L., The cis decoy against the estrogen response element suppresses breast cancer cells via target disrupting c-fos not mitogen-activated protein kinase activity (2003) Cancer Res, 63, pp. 2046-2051
Borgatti, M., Lampronti, I., Romanelli, A., Pedone, C., Saviano, M., Bianchi, N., Transcription factor decoy molecules based on a peptide nucleic acid (PNA)-DNA chimera mimicking Sp1 binding sites (2003) J Biol Chem, 278, pp. 7500-7509
Borgatti, M., Romanelli, A., Saviano, M., Pedone, C., Lampronti, I., Breda, L., Resistance of decoy PNA-DNA chimeras to enzymatic degradation in cellular extracts and serum (2003) Oncol Res, 13, pp. 279-287
Uhlmann, E., Peptide nucleic acids (PNA) and PNA-DNA chimeras: From high binding affinity towards biological function (1998) Biol Chem, 379, pp. 1045-1052
Mann, M.J., Whittemore, A.D., Donaldson, M.C., Belkin, M., Conte, M.S., Polak, J.F., Ex-vivo gene therapy of human vascular bypass grafts with E2F decoy: The PREVENT single-centre, randomised, controlled trial (1999) Lancet, 354, pp. 1493-1498
Novak, E.M., Metzger, M., Chammas, R., Da Costa, M., Dantas, K., Manabe, C., Downregulation of TNF-alpha and VEGF expression by Sp1 decoy oligodeoxynucleotides in mouse melanoma tumor (2003) Gene Ther, 10, pp. 1992-1997
Kubo, T., Kinjyo, N., Ikezawa, A., Kambe, T., Fukumori, R., Sp1 decoy oligodeoxynucleotide decreases angiotensin receptor expression and blood pressure in spontaneously hypertensive rats (2003) Brain Res, 992, pp. 1-8
Kawamura, I., Morishita, R., Tsujimoto, S., Manda, T., Tomoi, M., Tomita, N., Intravenous injection of oligodeoxynucleotides to the NF-kappaB binding site inhibits hepatic metastasis of M5076 reticulosarcoma in mice (2001) Gene Ther, 8, pp. 905-912
Matrisian, L.M., Sledge Jr., G.W., Mohla, S., Extracellular proteolysis and cancer: Meeting summary and future directions (2003) Cancer Res, 63, pp. 6105-6109
Coussens, L.M., Fingleton, B., Matrisian, L.M., Matrix metalloproteinase inhibitors and cancer: Trials and tribulations (2002) Science, 295, pp. 2387-2392
Chambers, A. F., Groom, A. C., MacDonald, I. C., Dissemination and growth of cancer cells in metastatic sites (2002) Nat Rev Cancer, 2, pp. 563-57
Andreasen, P. A., Egelund, R., Petersen, H. H., The plasminogen activation system in tumor growth, invasion, and metastasis (2000) Cell Mol Life Sci, 57, pp. 25-40
Look, M. P., Van Putten, W. L., Duffy, M. J., Harbeck, N., Christensen, I. J., Thomssen, C., Pooled analysis of prognostic impact of urokinase-type plasminogen activator and its inhibitor PAI-1 in 8377 breast cancer patients (2002) J Natl Cancer Inst, 94, pp. 116-128
Black, A. R., Black, J. D., Azizkhan-Clifford, J., Sp1 and kruppel-like factor family of transcription factors in cell growth regulation and cancer (2001) J Cell Physiol, 188, pp. 143-160
Samson, S. L., Wong, N. C., Role of Sp1 in insulin regulation of gene expression (2002) J Mol Endocrinol, 29, pp. 265-729
Kim, S. J., Onwuta, U. S., Lee, Y. I., Li, R., Botchan, M. R., Robbins, P. D., The retinoblastoma gene product regulates Sp1-mediated transcription (1992) Mol Cell Biol, 12, pp. 2455-2463
Schewe, D. M., Leupold, J. H., Boyd, D. D., Lengyel, E. R., Wang, H., Gruetzner, K. U., Tumor-specific transcription factor binding to an activator protein-2/Sp1 element of the urokinase-type plasminogen activator receptor promoter in a first large series of resected gastrointestinal cancers (2003) Clin Cancer Res, 9, pp. 2267-2276
Dignam, J. D., Lebovitz, R. M., Roeder, R. G., Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei (1983) Nucleic Acids Res, 11, pp. 1475-1489
Darnell Jr., J. E., Transcription factors as targets for cancer therapy (2002) Nat Rev Cancer, 2, pp. 740-749
Mann, M. J., Dzau, V. J., Therapeutic applications of transcription factor decoy oligonucleotides (2000) J Clin Invest, 106, pp. 1071-1075
Cho, Y. S., Kim, M. K., Cheadle, C., Neary, C., Park, Y. G., Becker, K. G., A genomic-scale view of the cAMP response element-enhancer decoy: A tumor target-based genetic tool (2002) Proc Natl Acad Sci USA, 99, pp. 15626-15631
Wang, L. H., Yang, X. Y., Zhang, X., Mihalic, K., Xiao, W., Farrar, W. L., The cis decoy against the estrogen response element suppresses breast cancer cells via target disrupting c-fos not mitogen-activated protein kinase activity (2003) Cancer Res, 63, pp. 2046-2051
Mann, M. J., Whittemore, A. D., Donaldson, M. C., Belkin, M., Conte, M. S., Polak, J. F., Ex-vivo gene therapy of human vascular bypass grafts with E2F decoy: The PREVENT single-centre, randomised, controlled trial (1999) Lancet, 354, pp. 1493-1498
Novak, E. M., Metzger, M., Chammas, R., Da Costa, M., Dantas, K., Manabe, C., Downregulation of TNF-alpha and VEGF expression by Sp1 decoy oligodeoxynucleotides in mouse melanoma tumor (2003) Gene Ther, 10, pp. 1992-1997
Matrisian, L. M., Sledge Jr., G. W., Mohla, S., Extracellular proteolysis and cancer: Meeting summary and future directions (2003) Cancer Res, 63, pp. 6105-6109
Coussens, L. M., Fingleton, B., Matrisian, L. M., Matrix metalloproteinase inhibitors and cancer: Trials and tribulations (2002) Science, 295, pp. 2387-2392
Biochem Pharmacol Biochemical Pharmacology (ISSN: 0006-2952, 1873-2968), 2005 Nov 1; 70(9): 1277-1287.
Tipo di articolo: Journal Article,
Impact factor: 3.617, Impact factor a 5 anni: 4.772
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-25644442324&partnerID=40&md5=ee6ad4844b2546aad2114f23c7770227
Parole chiave: Breast Cancer, Peptide Nucleic Acid, Pna-Dna Chimera, Sp1 Transcription Factor, Urokinase Receptor, Complementary Dna, Liposome, Oligonucleotide, Transcription Factor Sp1, Amino Acid Sequence, Article, Cancer Cell, Cancer Inhibition, Cell Migration, Cell Motility, Covalent Bond, Dna Strand, Down Regulation, Genetic Transfection, Human, Human Cell, In Vitro Study, Inhibition Kinetics, Metastasis, Priority Journal, Protein Binding, Protein Expression, Protein Function, Receptor Upregulation, Breast Neoplasms, Cell Line, Tumor, Cell Movement, Female, Cell Surface,
Affiliazioni:
*** IBB - CNR ***
Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale Delle Ricerche, Via S. Pansini 5, 80131 Naples, Italy
Istituto di Endocrinologia Ed Oncologia Sperimentale, Consiglio Nazionale Delle Ricerche, Naples, Italy
Istituto Internazionale di Genetica e Biofisica, Consiglio Nazionale Delle Ricerche, Naples, Italy
Dipartimento di Scienze Biomorfologiche e Funzionali, Universita' Federico II, Naples, Italy
Riferimenti:
Chambers, A.F., Groom, A.C., MacDonald, I.C., Dissemination and growth of cancer cells in metastatic sites (2002) Nat Rev Cancer, 2, pp. 563-57
Andreasen, P.A., Egelund, R., Petersen, H.H., The plasminogen activation system in tumor growth, invasion, and metastasis (2000) Cell Mol Life Sci, 57, pp. 25-40
Blasi, F., Carmeliet, P., UPAR: A versatile signalling orchestrator (2002) Nat Rev Mol Cell Biol, 3, pp. 932-943
Ossowski, L., Aguirre-Ghiso, J.A., Urokinase receptor and integrin partnership: Coordination of signaling for cell adhesion, migration and growth (2000) Curr Opin Cell Biol, 12, pp. 613-620
Harbeck, N., Kates, R.E., Look, M.P., Meijer-Van Gelder, M.E., Klijn, J.G., Kruger, A., Enhanced benefit from adjuvant chemotherapy in breast cancer patients classified high-risk according to urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor type 1 (n = 3424) (2002) Cancer Res, 62, pp. 4617-4622
Look, M.P., Van Putten, W.L., Duffy, M.J., Harbeck, N., Christensen, I.J., Thomssen, C., Pooled analysis of prognostic impact of urokinase-type plasminogen activator and its inhibitor PAI-1 in 8377 breast cancer patients (2002) J Natl Cancer Inst, 94, pp. 116-128
Fuchs, T., Allgayer, H., Transcriptional regulation of the urokinase receptor (u-PAR) - A central molecule of invasion and metastasis (2003) Biol Chem, 384, pp. 755-761
Soravia, E., Grebe, A., De Luca, P., Helin, K., Suh, T.T., Degen, J.L., A conserved TATA-less proximal promoter drives basal transcription from the urokinase-type plasminogen activator receptor gene (1995) Blood, 86, pp. 624-635
Allgayer, H., Wang, H., Gallick, G.E., Crabtree, A., Mazar, A., Jones, T., Transcriptional induction of the urokinase receptor gene by a constitutively active Src. Requirement of an upstream motif (-152/-135) bound with Sp1 (1999) J Biol Chem, 274, pp. 18428-18437
Black, A.R., Black, J.D., Azizkhan-Clifford, J., Sp1 and kruppel-like factor family of transcription factors in cell growth regulation and cancer (2001) J Cell Physiol, 188, pp. 143-160
Samson, S.L., Wong, N.C., Role of Sp1 in insulin regulation of gene expression (2002) J Mol Endocrinol, 29, pp. 265-729
Bouwman, P., Philipsen, S., Regulation of the activity of Sp1-related transcription factors (2002) Mol Cell Endocrinol, 195, pp. 27-38
Borellini, F., He, Y.F., Aquino, A., Yu, G., Josephs, S.F., Glazer, R.I., Increased DNA binding and transcriptional activity associated with transcription factor Sp1 in K562 cells transfected with the myeloid-specific c-fes tyrosine kinase gene (1991) J Biol Chem, 266, pp. 15850-15854
Kim, S.J., Onwuta, U.S., Lee, Y.I., Li, R., Botchan, M.R., Robbins, P.D., The retinoblastoma gene product regulates Sp1-mediated transcription (1992) Mol Cell Biol, 12, pp. 2455-2463
Sif, S., Capobianco, A.J., Gilmore, T.D., The v-Rel oncoprotein increases expression from Sp1 site-containing promoters in chicken embryo fibroblasts (1993) Oncogene, 8, pp. 2501-2509
Zannetti, A., Del Vecchio, S., Carriero, M.V., Fonti, R., Franco, P., Botti, G., Coordinate up-regulation of Sp1 DNA-binding activity and urokinase receptor expression in breast carcinoma (2000) Cancer Res, 60, pp. 1546-1551
Schewe, D.M., Leupold, J.H., Boyd, D.D., Lengyel, E.R., Wang, H., Gruetzner, K.U., Tumor-specific transcription factor binding to an activator protein-2/Sp1 element of the urokinase-type plasminogen activator receptor promoter in a first large series of resected gastrointestinal cancers (2003) Clin Cancer Res, 9, pp. 2267-2276
Ibanez-Tallon, I., Ferrai, C., Longobardi, E., Facetti, I., Blasi, F., Crippa, M.P., Binding of Sp1 to the proximal promoter links constitutive expression of the human uPA gene and invasive potential of PC3 cells (2002) Blood, 100, pp. 3325-3332
Benasciutti, E., Pages, G., Kenzior, O., Folk, W., Blasi, F., Crippa, M.P., MAPK and JNK transduction pathways can phosphorylate Sp1 to activate the uPA minimal promoter elements and endogenous gene transcription (2004) Blood, 104, pp. 256-262
Ray, A., Norden, B., Peptide nucleic acid (PNA): Its medical and biotechnical applications and promise for the future (2000) Faseb J, 14, pp. 1041-1060
Romanelli, A., Saviano, M., Pedone, C., Synthetic strategies for obtaining PNA and PNA conjugates (2004) Recent Res Dev Org Chem, 8, pp. 237-254
Dignam, J.D., Lebovitz, R.M., Roeder, R.G., Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei (1983) Nucleic Acids Res, 11, pp. 1475-1489
Darnell Jr., J.E., Transcription factors as targets for cancer therapy (2002) Nat Rev Cancer, 2, pp. 740-749
Mann, M.J., Dzau, V.J., Therapeutic applications of transcription factor decoy oligonucleotides (2000) J Clin Invest, 106, pp. 1071-1075
Cho, Y.S., Kim, M.K., Cheadle, C., Neary, C., Park, Y.G., Becker, K.G., A genomic-scale view of the cAMP response element-enhancer decoy: A tumor target-based genetic tool (2002) Proc Natl Acad Sci USA, 99, pp. 15626-15631
Morishita, R., Tomita, N., Kaneda, Y., Ogihara, T., Molecular therapy to inhibit NFkappaB activation by transcription factor decoy oligonucleotides (2004) Curr Opin Pharmacol, 4, pp. 139-146
Penolazzi, L., Lambertini, E., Borgatti, M., Piva, R., Cozzani, M., Giovannini, I., Decoy oligodeoxynucleotides targeting NF-kappaB transcription factors: Induction of apoptosis in human primary osteoclasts (2003) Biochem Pharmacol, 66, pp. 1189-1198
Wang, L.H., Yang, X.Y., Zhang, X., Mihalic, K., Xiao, W., Farrar, W.L., The cis decoy against the estrogen response element suppresses breast cancer cells via target disrupting c-fos not mitogen-activated protein kinase activity (2003) Cancer Res, 63, pp. 2046-2051
Borgatti, M., Lampronti, I., Romanelli, A., Pedone, C., Saviano, M., Bianchi, N., Transcription factor decoy molecules based on a peptide nucleic acid (PNA)-DNA chimera mimicking Sp1 binding sites (2003) J Biol Chem, 278, pp. 7500-7509
Borgatti, M., Romanelli, A., Saviano, M., Pedone, C., Lampronti, I., Breda, L., Resistance of decoy PNA-DNA chimeras to enzymatic degradation in cellular extracts and serum (2003) Oncol Res, 13, pp. 279-287
Uhlmann, E., Peptide nucleic acids (PNA) and PNA-DNA chimeras: From high binding affinity towards biological function (1998) Biol Chem, 379, pp. 1045-1052
Mann, M.J., Whittemore, A.D., Donaldson, M.C., Belkin, M., Conte, M.S., Polak, J.F., Ex-vivo gene therapy of human vascular bypass grafts with E2F decoy: The PREVENT single-centre, randomised, controlled trial (1999) Lancet, 354, pp. 1493-1498
Novak, E.M., Metzger, M., Chammas, R., Da Costa, M., Dantas, K., Manabe, C., Downregulation of TNF-alpha and VEGF expression by Sp1 decoy oligodeoxynucleotides in mouse melanoma tumor (2003) Gene Ther, 10, pp. 1992-1997
Kubo, T., Kinjyo, N., Ikezawa, A., Kambe, T., Fukumori, R., Sp1 decoy oligodeoxynucleotide decreases angiotensin receptor expression and blood pressure in spontaneously hypertensive rats (2003) Brain Res, 992, pp. 1-8
Kawamura, I., Morishita, R., Tsujimoto, S., Manda, T., Tomoi, M., Tomita, N., Intravenous injection of oligodeoxynucleotides to the NF-kappaB binding site inhibits hepatic metastasis of M5076 reticulosarcoma in mice (2001) Gene Ther, 8, pp. 905-912
Matrisian, L.M., Sledge Jr., G.W., Mohla, S., Extracellular proteolysis and cancer: Meeting summary and future directions (2003) Cancer Res, 63, pp. 6105-6109
Coussens, L.M., Fingleton, B., Matrisian, L.M., Matrix metalloproteinase inhibitors and cancer: Trials and tribulations (2002) Science, 295, pp. 2387-2392
Chambers, A. F., Groom, A. C., MacDonald, I. C., Dissemination and growth of cancer cells in metastatic sites (2002) Nat Rev Cancer, 2, pp. 563-57
Andreasen, P. A., Egelund, R., Petersen, H. H., The plasminogen activation system in tumor growth, invasion, and metastasis (2000) Cell Mol Life Sci, 57, pp. 25-40
Look, M. P., Van Putten, W. L., Duffy, M. J., Harbeck, N., Christensen, I. J., Thomssen, C., Pooled analysis of prognostic impact of urokinase-type plasminogen activator and its inhibitor PAI-1 in 8377 breast cancer patients (2002) J Natl Cancer Inst, 94, pp. 116-128
Black, A. R., Black, J. D., Azizkhan-Clifford, J., Sp1 and kruppel-like factor family of transcription factors in cell growth regulation and cancer (2001) J Cell Physiol, 188, pp. 143-160
Samson, S. L., Wong, N. C., Role of Sp1 in insulin regulation of gene expression (2002) J Mol Endocrinol, 29, pp. 265-729
Kim, S. J., Onwuta, U. S., Lee, Y. I., Li, R., Botchan, M. R., Robbins, P. D., The retinoblastoma gene product regulates Sp1-mediated transcription (1992) Mol Cell Biol, 12, pp. 2455-2463
Schewe, D. M., Leupold, J. H., Boyd, D. D., Lengyel, E. R., Wang, H., Gruetzner, K. U., Tumor-specific transcription factor binding to an activator protein-2/Sp1 element of the urokinase-type plasminogen activator receptor promoter in a first large series of resected gastrointestinal cancers (2003) Clin Cancer Res, 9, pp. 2267-2276
Dignam, J. D., Lebovitz, R. M., Roeder, R. G., Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei (1983) Nucleic Acids Res, 11, pp. 1475-1489
Darnell Jr., J. E., Transcription factors as targets for cancer therapy (2002) Nat Rev Cancer, 2, pp. 740-749
Mann, M. J., Dzau, V. J., Therapeutic applications of transcription factor decoy oligonucleotides (2000) J Clin Invest, 106, pp. 1071-1075
Cho, Y. S., Kim, M. K., Cheadle, C., Neary, C., Park, Y. G., Becker, K. G., A genomic-scale view of the cAMP response element-enhancer decoy: A tumor target-based genetic tool (2002) Proc Natl Acad Sci USA, 99, pp. 15626-15631
Wang, L. H., Yang, X. Y., Zhang, X., Mihalic, K., Xiao, W., Farrar, W. L., The cis decoy against the estrogen response element suppresses breast cancer cells via target disrupting c-fos not mitogen-activated protein kinase activity (2003) Cancer Res, 63, pp. 2046-2051
Mann, M. J., Whittemore, A. D., Donaldson, M. C., Belkin, M., Conte, M. S., Polak, J. F., Ex-vivo gene therapy of human vascular bypass grafts with E2F decoy: The PREVENT single-centre, randomised, controlled trial (1999) Lancet, 354, pp. 1493-1498
Novak, E. M., Metzger, M., Chammas, R., Da Costa, M., Dantas, K., Manabe, C., Downregulation of TNF-alpha and VEGF expression by Sp1 decoy oligodeoxynucleotides in mouse melanoma tumor (2003) Gene Ther, 10, pp. 1992-1997
Matrisian, L. M., Sledge Jr., G. W., Mohla, S., Extracellular proteolysis and cancer: Meeting summary and future directions (2003) Cancer Res, 63, pp. 6105-6109
Coussens, L. M., Fingleton, B., Matrisian, L. M., Matrix metalloproteinase inhibitors and cancer: Trials and tribulations (2002) Science, 295, pp. 2387-2392
Sp1 regulates the activation of many genes involved in tumor growth, apoptosis, and angiogenesis. We have previously shown the involvement of Sp1 in the up-regulation of urokinase receptor (uPAR) expression, a key molecule in tumor invasion and metastasis. Here, we investigated whether a marked down-regulation of Sp1 activity may inhibit uPAR expression and migration ability of MDA-MB-231 breast cancer cells. To this end, we tested the decoy ability of a novel peptide nucleic acid (PNA)-DNA chimera which carries a central DNA strand, containing Sp1-binding sequence, covalently linked to two PNA fragments at both ends (PNA-DNA-PNA, PDP). The chimera was synthesized, annealed with complementary DNA (PDP-DNA), and then tested for its ability to bind Sp1 both in vitro and in living MDA-MB-231 breast cancer cells in the presence of urokinase (uPA). This PDP-DNA decoy molecule efficiently competes for the binding to endogenous Sp1 in nuclear extracts, and upon transfection with liposomal vectors, causes a marked decrease of available Sp1 in both untreated and uPA-treated MDA-MB-231 cells. Accordingly, both uPA-dependent enhancement of uPAR expression and cell migration were strongly reduced in transfected cells. Interestingly, a detectable inhibitory effect is also observed in breast cancer cells exposed to PDP-DNA in the absence of transfection reagents. Finally, the inhibitory effect of PDP-DNA appeared to be stronger than that observed with oligonucleotides carrying Sp1 consensus sequence. Our findings show that this novel PNA-DNA chimera, containing Sp1 consensus sequence, effectively inhibits Sp1 activity, uPAR expression, and motility of breast cancer cells indicating its potential therapeutic use to prevent tumor dissemination. (c) 2005 Elsevier Inc. All rights reserved.
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Salvatore B, Caprio MG, Hill BS, Sarnella A, Roviello GN, Zannetti A
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D'Agata R, Spoto G
* Artificial DNA and surface plasmon resonance (279 visite)
Artificial Dna Pna & Xna (ISSN: 1949-095x), 2012 Apr; 3(2): N/D-N/D.
Impact Factor: 0
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Avitabile C, Saviano M, D'Andrea LD, Bianchi N, Fabbri E, Brognara E, Gambari R, Romanelli A
* Targeting pre-miRNA by peptide nucleic acids: a new strategy to interfere in the miRNA maturation (208 visite)
Artif Dna Pna Xnaartificial Dna Pna & Xna (ISSN: 1949-9096, 1949-0968, 1949-095x), 2012 Apr; 3(2): 88-96.
Impact Factor: 0
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Folgiero V, Di Carlo SE, Bossi G, Spugnini E, Di Benedetto A, Bon G, Milella M, Fabi A, Accardo A, Morelli G, Mottolese M, Falcioni R
* Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells (200 visite)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2012; 3(12): N/D-N/D.
Impact Factor: 6.044
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Accardo A, Salsano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Tesauro D, Aloj L, De Rosa G, Morelli G
* Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells: A potential theranostic agent (184 visite)
Int J Nanomed (ISSN: 1176-9114, 1178-2013, 1178-2013electronic), 2012; 7: 2007-2017.
Impact Factor: 3.463
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Cantisani M, Vitiello M, Falanga A, Finamore E, Galdiero M, Galdiero S
* Peptides complementary to the active loop of porin P2 from Haemophilus influenzae modulate its activity (277 visite)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1178-2013electronic), 2012; 7: 2361-2371.
Impact Factor: 3.463
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Pacelli R, Conson M, Cella L, Liuzzi R, Solla R, Iorio V, Farella A, Salvatore M
* Prediction Of Relapse And Contralateral Tumor Using Breast Cancer Clinical Variables And Histochemical Subtypes (150 visite)
Radiother Oncol (ISSN: 0167-8140, 1879-0887, 1879-0887electronic), 2012; 103: s246-s246.
Impact Factor: 4.52
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D'Errico G, Ercole C, Lista M, Pizzo E, Falanga A, Galdiero S, Spadaccini R, Picone D
* Enforcing the positive charge of N-termini enhances membrane interaction and antitumor activity of bovine seminal ribonuclease (214 visite)
Bba-Mol Basis Dis (ISSN: 0005-2736, 0006-3002, 0925-4439), 2011 Dec; 1808(12): 3007-3015.
Impact Factor: 3.99
Dettagli Esporta in BibTeX Esporta in EndNote
Tarallo R, Accardo A, Falanga A, Guarnieri D, Vitiello G, Netti P, D'Errico G, Morelli G, Galdiero S
* Clickable functionalization of liposomes with the gH625 peptide from herpes simplex virus type i for intracellular drug delivery (194 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Nov 4; 17(45): 12659-12668.
Impact Factor: 5.925
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Roviello GN, Musumeci D, Bucci EM, Pedone C
* Synthesis and characterization of a novel ester-based nucleoamino acid for the assembly of aromatic nucleopeptides for biomedical applications (281 visite)
Int J Pharm (ISSN: 0378-5173, 1873-3476), 2011 Sep 30; 415(1-2): 206-210.
Impact Factor: 3.35
Dettagli Esporta in BibTeX Esporta in EndNote
Musumeci D, Bucci EM, Roviello GN, Sapio R, Valente M, Moccia M, Bianchi ME, Pedone C
* DNA-based strategies for blocking HMGB1 cytokine activity: Design, synthesis and preliminary in vitro/in vivo assays of DNA and DNA-like duplexes (195 visite)
Mol Biosyst (ISSN: 1742-206x, 1742-2051, 1742-2051electronic), 2011 May; 7(5): 1742-1752.
Impact Factor: 3.534
Dettagli Esporta in BibTeX Esporta in EndNote
Roviello GN, Ricci A, Bucci EM, Pedone C
* Synthesis, biological evaluation and supramolecular assembly of novel analogues of peptidyl nucleosides (523 visite)
Mol Biosyst (ISSN: 1742-206x, 1742-2051, 1742-2051electronic), 2011 May; 7(5): 1773-1778.
Impact Factor: 3.534
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Terreno E, Boffa C, Menchise V, Fedeli F, Carrera C, Castelli DD, Digilio G, Aime S
* Gadolinium-doped LipoCEST agents: A potential novel class of dual 1H-MRI probes (158 visite)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2011 Apr 28; 47(16): 4667-4669.
Impact Factor: 6.169
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Falciani C, Accardo A, Brunetti J, Tesauro D, Lelli B, Pini A, Bracci L, Morelli G
* Target-Selective Drug Delivery through Liposomes Labeled with Oligobranched Neurotensin Peptides (243 visite)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2011 Apr 4; 6(4): 678-685.
Impact Factor: 3.151
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Troise F, Monti M, Merlino A, Cozzolino F, Fedele C, Russo Krauss I, Sica F, Pucci P, D'Alessio G, De Lorenzo C
* A novel ErbB2 epitope targeted by human antitumor immunoagents (158 visite)
Febs Journal (ISSN: 1742-464x), 2011 Apr; 278(7): 1156-1166.
Impact Factor: 3.79
Dettagli Esporta in BibTeX Esporta in EndNote
Roviello GN, Musumeci D, Bucci EM, Pedone C
* Evidences for supramolecular organization of nucleopeptides: Synthesis, spectroscopic and biological studies of a novel dithymine l-serine tetrapeptide (218 visite)
Mol Biosyst (ISSN: 1742-206x, 1742-2051, 1742-2051electronic), 2011 Apr; 7(4): 1073-1080.
Impact Factor: 3.534
Dettagli Esporta in BibTeX Esporta in EndNote
Accardo A, Morisco A, Tesauro D, Pedone C, Morelli G
* Naposomes: A new class of peptide-derivatized, target-selective multimodal nanoparticles for imaging and therapeutic applications (224 visite)
Ther Deliv (ISSN: 2041-5990), 2011 Feb; 2(2): 235-257.
Impact Factor: 0
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Morisco A, Accardo A, Tesauro D, Palumbo R, Benedetti E, Morelli G
* Peptide-labeled supramolecular aggregates as selective doxorubicin carriers for delivery to tumor cells (169 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2011; 96(1): 88-96.
Impact Factor: 2.87
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Gallucci G, Coccaro M, Storto G, Lapadula L, Tartarone A, Nappi A, Cammarota A, Buonerba C, Di Lorenzo G, Fusco V, Aieta M
* The clinical impact of a cardiologic follow-up in breast cancer survivors: an observational study (143 visite)
Int J Immunopathol Pharmacol (ISSN: 0394-6320), 2010 Oct; 23(4): 1221-1227.
Impact Factor: 2.685
Dettagli Esporta in BibTeX Esporta in EndNote
Pensato S, Saviano M, Bianchi N, Borgatti M, Fabbri E, Gambari R, Romanelli A
* Gamma-Hydroxymethyl Pnas: Synthesis, Interaction With Dna And Inhibition Of Protein/Dna Interactions (175 visite)
Bioorg Chem, 2010 Sep; 38(5): 196-201.
Impact Factor: 2.141
Dettagli Esporta in BibTeX Esporta in EndNote
Roviello GN, Crescenzo C, Capasso D, Di Gaetano S, Franco S, Bucci EM, Pedone C
* Synthesis of a novel Fmoc-protected nucleoaminoacid for the solid phase assembly of 4-piperidyl glycine/L-arginine-containing nucleopeptides and preliminary RNA interaction studies (217 visite)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 Sep; 39(3): 795-800.
Impact Factor: 4.106
Dettagli Esporta in BibTeX Esporta in EndNote
Avitabile C, Moggio L, D'Andrea LD, Pedone C, Romanelli A
* Development of an efficient and low-cost protocol for the manual PNA synthesis by Fmoc chemistry (176 visite)
Tetrahedron Lett (ISSN: 0040-4039), 2010 Jul 21; 51(29): 3716-3718.
Impact Factor: 2.618
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Bombardieri E, Ambrosini V, Aktolun C, Baum RP, Bishof-delaloye A, Del Vecchio S, Maffioli L, Mortelmans L, Oyen W, Pepe G, Chiti A
* In-111-pentetreotide scintigraphy: procedure guidelines for tumour imaging (204 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2010 Jul; 37(7): 1441-1448.
Impact Factor: 5.036
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Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Pizzuti LM, Lettieri A, Salvatore M
* PET/CT in cancer research: From preclinical to clinical applications (346 visite)
Contrast Media Mol Imaging (ISSN: 1555-4309, 1555-4309linking), 2010 Jul; 5(4): 190-200.
Impact Factor: 4.02
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Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment (216 visite)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 243-258.
Impact Factor: 1.724
Dettagli Esporta in BibTeX Esporta in EndNote
Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment: Challenges and perspectives (302 visite)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 249-258.
Impact Factor: 1.724
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Galdiero S, Falanga A, Vitiello M, Raiola L, Russo L, Pedone C, Isernia C, Galdiero M
* The presence of a single N-terminal histidine residue enhances the fusogenic properties of a Membranotropic peptide derived from herpes simplex virus type 1 glycoprotein (144 visite)
J Biol Chem (ISSN: 1083-351x, 0021-9258), 2010 May 28; 285(22): 17123-17136.
Impact Factor: 5.328
Dettagli Esporta in BibTeX Esporta in EndNote
D'Agata R, Corradini R, Ferretti C, Zanoli L, Gatti M, Marchelli R, Spoto G
* Ultrasensitive detection of non-amplified genomic DNA (208 visite)
Lect Notes Electr Eng, 2010 May 15; 91LNEE: 485-488.
Impact Factor: 0
Dettagli Esporta in BibTeX Esporta in EndNote
D'Agata R, Corradini R, Ferretti C, Zanoli L, Gatti M, Marchelli R, Spoto G
* Ultrasensitive detection of non-amplified genomic DNA by nanoparticle-enhanced surface plasmon resonance imaging (142 visite)
Biosens Bioelectron (ISSN: 0956-5663, 1873-4235electronic), 2010 May 15; 25(9): 2095-2100.
Impact Factor: 5.361
Dettagli Esporta in BibTeX Esporta in EndNote
Accardo A, Mansi R, Morisco A, Mangiapia G, Paduano L, Tesauro D, Radulescu A, Aurilio M, Aloj L, Arra C, Morelli G
* Peptide modified nanocarriers for selective targeting of bombesin receptors (145 visite)
Mol Biosyst (ISSN: 1742-206x), 2010 May; 6(5): 878-887.
Impact Factor: 3.825
Dettagli Esporta in BibTeX Esporta in EndNote
Pensato S, Renda M, Leccia F, Saviano M, D'Andrea LD, Pedone C, Pedone PV, Romanelli A
* PNA zipper as a dimerization tool: development of a bZip mimic (209 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2010 May; 93(5): 434-441.
Impact Factor: 2.572
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Roviello GN, Gröschel S, Pedone C, Diederichsen U
* Synthesis of novel MMT/acyl-protected nucleo alanine monomers for the preparation of DNA/alanyl-PNA chimeras (163 visite)
Amino Acids (ISSN: 1438-2199, 0939-4451, 1438-2199electronic), 2010 May; 38(5): 1301-1309.
Impact Factor: 4.106
Dettagli Esporta in BibTeX Esporta in EndNote
Roviello GN, Di Gaetano S, Capasso D, Cesarani A, Bucci EM, Pedone C
* Synthesis, spectroscopic studies and biological activity of a novel nucleopeptide with Moloney murine leukemia virus reverse transcriptase inhibitory activity (180 visite)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 May; 38(5): 1489-1496.
Impact Factor: 4.106
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Conson M, D'Amato G, Nieddu V, Pagliarulo C, Iorio V, Vernieri C, Farella A, Solla R, Cella L, Liuzzi R, Punzo G, Salvatore M, Pacelli R
* Patterns of distant and local relapses in breast cancer patients and triple negative subgroup (166 visite)
Meetingproceedings Of The American Association For Cancer Research Annual (ISSN: 0197-016x), 2010 Apr; 51: N/D-N/D.
Impact Factor: 0
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Alberobello AT, D'Esposito V, Marasco D, Doti N, Ruvo M, Bianco R, Tortora G, Esposito I, Fiory F, Miele C, Beguinot F, Formisano P
* Selective Disruption of Insulin-like Growth Factor-1 (IGF-1) Signaling via Phosphoinositide-dependent Kinase-1 Prevents the Protective Effect of IGF-1 on Human Cancer Cell Death (169 visite)
J Biol Chem (ISSN: 0021-9258, 1083-351x), 2010 Feb 26; 285(9): 6563-6572.
Impact Factor: 5.328
Dettagli Esporta in BibTeX Esporta in EndNote
Roviello GN, Musumeci D, Pedone C, Bucci EM
* Synthesis, Characterization And Hybridization Studies Of An Alternate Nucleo-Epsilon/Gamma-Peptide: Complexes Formation With Natural Nucleic Acids (195 visite)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 Jan; 38(1): 103-111.
Impact Factor: 4.106
Dettagli Esporta in BibTeX Esporta in EndNote
D'Agata R, Breveglieri G, Zanoli L, Borgatti M, Spoto G, Gambari R
* Surface Plasmon Resonance Imaging (SPR-I), peptide nucleic acid (PNA) probes and nanoparticle-enhancement for PCR-free ultrasensitive detection of beta-thalassemia mutations in human genomic DNA (133 visite)
International Journal Of Molecular Medicine (ISSN: 1107-3756), 2010; 26: N/D-N/D.
Impact Factor: 1.814
Dettagli Esporta in BibTeX Esporta in EndNote
Moccia M, Musumeci D, Roviello GN, Fusco S, Valente M, Bucci EM, Sapio R, Pedonea C, Netti PA
* Preliminary studies on noncovalent hyperbranched polymers based on PNA and DNA building blocks (262 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Oct; 15(10): 647-653.
Impact Factor: 1.807
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Carriero MV, Longanesi-cattani I, Bifulco K, Maglio O, Lista L, Barbieri A, Votta G, Masucci MT, Arra C, Franco R, De Rosa M, Stoppelli MP, Pavone V
* Structure-based design of an urokinase-type plasminogen activator receptor-derived peptide inhibiting cell migration and lung metastasis (206 visite)
Mol Cancer Ther (ISSN: 1535-7163, 1538-8514electronic, 1535-7163linking), 2009 Sep; 8(9): 2708-2717.
Impact Factor: 4.953
Dettagli Esporta in BibTeX Esporta in EndNote
Accardo A, Tesauro D, Aloj L, Pedone C, Morelli G
* Supramolecular aggregates containing lipophilic Gd(III) complexes as contrast agents in MRI (142 visite)
Coord Chem Rev (ISSN: 0010-8545), 2009 Sep; 253(17-18): 2193-2213.
Impact Factor: 11.225
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Imbriaco M, Pisani A, Spinelli L, Cuocolo A, Messalli G, Capuano E, Marmo M, Liuzzi R, Visciano B, Cianciaruso B, Salvatore M
* Effects of enzyme-replacement therapy in patients with Anderson-Fabry disease: a prospective long-term cardiac magnetic resonance imaging study (152 visite)
Heart (ISSN: 1355-6037, 1468-201x), 2009 Jul; 95(13): 1103-1107.
Impact Factor: 5.385
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Storto G, Nicolai E, Salvatore M
* [18F]FDG-PET-CT for early monitoring of tumor response: When and why (179 visite)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2009 Apr; 53(2): 167-180.
Impact Factor: 1.724
Dettagli Esporta in BibTeX Esporta in EndNote
Roviello GN, Musumeci D, Moccia M, Castiglione M, Cesarani A, Bucci EM, Saviano M, Pedone C, Benedetti E
* Evidences Of Complex Formation Between Daba-Based Nucleo-Gamma-Peptides With Alternate Configuration Backbone (217 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 147-154.
Impact Factor: 1.807
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Zaccaro L, Del Gatto A, Pedone C, Saviano M
* Peptides for tumour therapy and diagnosis: current status and future directions (272 visite)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2009 Mar; 16(7): 780-795.
Impact Factor: 4.708
Dettagli Esporta in BibTeX Esporta in EndNote
Roviello GN, Musumeci D, Castiglione M, Bucci EM, Pedone C, Benedetti E
* Solid Phase Synthesis And Rna-Binding Studies Of A Serum-Resistant Nucleo-Epsilon-Peptide (174 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 155-160.
Impact Factor: 1.807
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Insabato L, Amelio I, Quarto M, Zannetti A, Tolino F, De Mauro G, Cerchia L, Riccio P, Baumhoer D, Condorelli G, Terracciano L, De Franciscis V
* Elevated Expression of the Tyrosine Phosphatase SHP-1 Defines a Subset of High-Grade Breast Tumors (219 visite)
Oncology (ISSN: 0030-2414), 2009; 77(6): 378-384.
Impact Factor: 2.112
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Marasco D, Perretta G, Sabatella M, Ruvo M
* Past and Future Perspectives of Synthetic Peptide Libraries (183 visite)
Curr Protein Pept Sci (ISSN: 1389-2037), 2008 Oct; 9(5): 447-467.
Impact Factor: 3.011
Dettagli Esporta in BibTeX Esporta in EndNote
Roviello GN, Musumeci D, Bucci EM, Castiglione M, Cesarani A, Pedone C, Piccialli G
* Evidences for complex formation between l-dabPNA and aegPNA (152 visite)
Bioorg Med Chem Lett (ISSN: 0960-894x, 1464-3405, 1464-3405electronic), 2008 Sep 1; 18(17): 4757-4760.
Impact Factor: 2.531
Dettagli Esporta in BibTeX Esporta in EndNote
D'Agata R, Corradini R, Grasso G, Marchelli R, Spoto G
* Ultrasensitive detection of DNA by PNA and nanoparticle-enhanced surface plasmon resonance imaging (222 visite)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2008 Sep 1; 9(13): 2067-2070.
Impact Factor: 3.322
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Woo LWL, Fischer DS, Sharland CM, Trusselle M, Foster PA, Chander SK, Di Fiore A, Supuran CT, De Simone G, Purohit A, Reed MJ, Potter BVL
* Anticancer steroid sulfatase inhibitors: synthesis of a potent fluorinated second-generation agent, in vitro and in vivo activities, molecular modeling, and protein crystallography (196 visite)
Mol Cancer Ther (ISSN: 1535-7163, 1538-8514electronic), 2008 Sep; 7(8): 2435-2444.
Impact Factor: 5.003
Dettagli Esporta in BibTeX Esporta in EndNote
Dalla Serra M, Cirioni O, Vitale RM, Renzone G, Coraiola M, Giacometti A, Potrich C, Baroni E, Guella G, Sanseverino M, De Luca S, Scalise G, Amodeo P, Scaloni A
* Structural features of distinctin affecting peptide biological and biochemical properties (212 visite)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2008 Jul 29; 47(30): 7888-7899.
Impact Factor: 3.379
Dettagli Esporta in BibTeX Esporta in EndNote
Sinibaldi F, Fiorucci L, Patriarca A, Lauceri R, Ferri T, Coletta M, Santucci R
* Insights into cytochrome c-cardiolipin interaction. Role played by ionic strength (151 visite)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2008 Jul 1; 47(26): 6928-6935.
Impact Factor: 3.379
Dettagli Esporta in BibTeX Esporta in EndNote
Bifulco K, Longanesi-cattani I, Gargiulo L, Maglio O, Cataldi M, De Rosa M, Stoppelli MP, Pavone V, Carriero MV
* An urokinase receptor antagonist that inhibits cell migration by blocking the formyl peptide receptor (151 visite)
Febs Lett (ISSN: 0014-5793print, 0014-5793linking, 1873-3468electronic), 2008 Apr 2; 582(7): 1141-1146.
Impact Factor: 3.264
Dettagli Esporta in BibTeX Esporta in EndNote
Galdiero S, Vitiello M, D'Isanto M, Falanga A, Cantisani M, Browne H, Pedone C, Galdiero M
* The identification and characterization of fusogenic domains in herpes virus glycoprotein B molecules (177 visite)
Chembiochem (ISSN: 1439-7633, 1439-4227, 1439-7633electronic), 2008 Mar 25; 9(5): 758-767.
Impact Factor: 3.322
Dettagli Esporta in BibTeX Esporta in EndNote
Pensato S, D'Andrea LD, Pedone C, Romanelli A
* New synthetic route to gamma-mercaptomethyl PNA monomers (175 visite)
Synth Commun Synthetic Communications (ISSN: 0039-7911), 2008; 38(15): 2499-2506.
Impact Factor: 0.981
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Breveglieri G, Pensato S, Salvatori F, Saviano M, Pedone C, Romanelli A, Gambari R
* PNA-mediated alteration of mRNA splicing (140 visite)
Minerva Biotecnol (ISSN: 1120-4826), 2008; 20(4): 175-181.
Impact Factor: 0.1
Dettagli Esporta in BibTeX Esporta in EndNote
Marchelli R, Saviano M, Licandro E, Spoto G, Borgatti M, Gambari R
* PNAs targeting the "RNA world": Micro RNA next? (163 visite)
Minerva Biotecnol (ISSN: 1120-4826), 2008; 20(4): 183-188.
Impact Factor: 0.1
Dettagli Esporta in BibTeX Esporta in EndNote
Zanoli L, Dagata R, Spoto G
* Surface plasmon-based optical detection of DNA peptide nucleic acids (148 visite)
Minerva Biotecnol (ISSN: 1120-4826), 2008; 20(4): 165-174.
Impact Factor: 0.1
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Salvatore A, Cigliano L, Bucci EM, Corpillo D, Velasco S, Carlucci A, Pedone C, Abrescia P
* Haptoglobin binding to apolipoprotein A-I prevents damage from hydroxyl radicals on its stimulatory activity of the enzyme lecithin-cholesterol acyl-transferase (164 visite)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2007 Oct 2; 46(39): 11158-11168.
Impact Factor: 3.368
Dettagli Esporta in BibTeX Esporta in EndNote
Pensato S, Saviano M, Romanelli A
* New peptide nucleic acid analogues: synthesis and applications (210 visite)
Expert Opinion On Biological Therapy (ISSN: 1471-2598), 2007 Sep; 7(8): 1219-1232.
Impact Factor: 2.815
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Chambery A, Pisante M, Di Maro A, Di Zazzo E, Ruvo M, Costantini S, Colonna G, Parente A
* Invariant Ser211 is involved in the catalysis of PD-L4, type I RIP from Phytolacca dioica leaves (143 visite)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2007 Apr 1; 67(1): 209-218.
Impact Factor: 3.354
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Cusanno F, Cisbani E, Colilli S, Fratoni R, Garibaldi F, Giuliani F, Gricia M, Lucentini M, Magliozzi ML, Santarivenere F, Torrioli S, Cinti MN, Pani R, Pellegrini R, Simonetti G, Schillaci O, Del Vecchio S, Salvatore M, Majewski S, De Vincentis G, Scopinaro F
* Results of clinical trials with SPEM (149 visite)
Nucl Instrum Methods Phys Res Sect A, 2007 Feb 1; 497(1): 46-50.
Impact Factor: 3.221
Dettagli Esporta in BibTeX Esporta in EndNote
Roviello GN, Musumeci D, Moccia M, Castiglione M, Sapio R, Valente M, Bucci EM, Perretta G, Pedone C
* Dabpna: Design, Synthesis And Nucleic Acids Binding Studies (195 visite)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1525-7770), 2007; 26(10-12): 1307-1310.
Impact Factor: 0.723
Dettagli Esporta in BibTeX Esporta in EndNote
Moccia M, Musumeci D, Valente M, Roviello GN, Sapio R, Pedone C, Bucci EM
* Thermodynamic studies on PNA and PNA/DNA dendrimer formation (116 visite)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1525-7770), 2007; 26(8-9): 1173-1176.
Impact Factor: 0.723
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Garibaldi F, Cisbani E, Colilli S, Cusanno F, Fratoni R, Giuliani F, Gricia M, Lucentini M, Fratoni R, Lo Meo S, Magliozzi ML, Santanvenere F, Cinti MN, Pani R, Pellegrini R, Simonetti G, Schillaci O, Del Vecchio S, Salvatore M, Majewski S, Lanza RC, De Vincentis G, Scopinaro F
* Molecular imaging: High-resolution detectors for early diagnosis and therapy monitoring of breast cancer (193 visite)
Nucl Instrum Meth A (ISSN: 0168-9002), 2006 Dec 20; 569(2SPEC.ISS.): 286-290.
Impact Factor: 1.185
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Roviello GN, Moccia M, Sapio R, Valente M, Bucci EM, Castiglione M, Pedone C, Perretta G, Benedetti E, Musumeci D
* Synthesis, Characterization And Hybridization Studies Of New Nucleo-Gamma-Peptides Based On Diaminobutyric Acid (215 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Dec; 12(12): 829-835.
Impact Factor: 1.801
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Musumeci D, Valente M, Capasso D, Palumbo R, Gorlach M, Schmidtke M, Zell R, Roviello GN, Sapio R, Pedone C, Bucci EM
* A short PNA targeting coxsackievirus B3 5′-nontranslated region prevents virus-induced cytolysis (129 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Mar; 12(3): 161-170.
Impact Factor: 1.801
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Del Vecchio S, Zannetti A, Salvatore B, Paone G, Fonti R, Salvatore M
* Functional imaging of multidrug resistance in breast cancer (221 visite)
Phys Med (ISSN: 1120-1797, 1120-1797linking), 2006; 21(SUPPL.1): 24-27.
Impact Factor: 0.313
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Galdiero S, Falanga A, Vitiello M, Browne H, Pedone C, Galdiero M
* Fusogenic domains in herpes simplex virus type 1 glycoprotein (198 visite)
J Biol Chem (ISSN: 0021-9258, 1083-351x), 2005 Sep 5; 280(31): 28632-28643.
Impact Factor: 5.854
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Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Sommella I, Potena A, Salvatore M
* 99mTc-MIBI uptake in Bcl-2 overexpressing breast cancer cells during treatment with gefitinib, a selective tyrosine kinase inhibitor (207 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2005 Sep; 32: N/D-N/D.
Impact Factor: 3.883
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Lauria A, Palmiero R, Forni G, Fantacci ME, Imbriaco M, Sodano A, Indovina PL
* A Study On Two Different Cad Systems For Mmammography As An Aid To Radiological Diagnosis In The Search Of Microcalcification Clusters (150 visite)
Eur J Radiol (ISSN: 0720-048x), 2005; 55(2): 264-269.
Impact Factor: 1.888
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Borgatti M, Boyd DD, Lampronti I, Bianchi N, Fabbri E, Saviano M, Romanelli A, Pedone C, Gambari R
* Decoy molecules based on PNA-DNA chimeras and targeting Sp1 transcription factors inhibit the activity of urokinase-type plasminogen activator receptor (uPAR) promoter (171 visite)
Oncology Research (ISSN: 0965-0407), 2005; 15(7-8): 373-383.
Impact Factor: 1.844
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Russo M, Tedesco I, Iacomino G, Palumbo R, Galano G, Russo GL
* Dietary phytochemicals in chemoprevention of cancer (145 visite)
Curr Med Chem (ISSN: 1568-0134), 2005; 5(1): 61-72.
Impact Factor: 3.715
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Zannetti A, Del Vecchio S, Fonti R, Iommelli F, Sommella J, Potena A, Salvatore M
* Gefitinib, A Selective, Tyrosine Kinase Inhibitor Increases 99mtc-Mibi Uptake In Bcl-2 Overexpressing Breast Cancer Cells (205 visite)
Mol Immunol, 2005; 4: 355-355.
Impact Factor: 3.003
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Borgatti M, Finotti A, Romanelli A, Saviano M, Bianchi N, Lampronti I, Lambertini E, Penolazzi L, Nastruzzi C, Mischiati C, Piva R, Pedone C, Gambari R
* Peptide nucleic acids (PNA)-DNA chimeras targeting transcription factors as a tool to modify gene expression (178 visite)
Curr Drug Targets (ISSN: 1389-4501), 2004 Nov; 5(8): 735-744.
Impact Factor: 4.104
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Mischiati C, Sereni A, Finotti A, Breda L, Cortesi R, Nastruzzi C, Romanelli A, Saviano M, Bianchi N, Pedone C, Borgatti M, Gambari R
* Complexation to cationic microspheres of double-stranded peptide nucleic acid-DNA chimeras exhibiting decoy activity (135 visite)
Journal Of Biomedical Science (ISSN: 1021-7770), 2004 Sep; 11(5): 697-704.
Impact Factor: 1.567
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Penolazzi L, Borgatti M, Lambertini E, Mischiati C, Finotti A, Romanelli A, Saviano M, Pedone C, Piva R, Gambari R
* Peptide nucleic acid-DNA decoy chimeras targeting NF-kappa B transcription factors: Induction of apoptosis in human primary osteoclasts (157 visite)
International Journal Of Molecular Medicine (ISSN: 1107-3756), 2004 Sep; 14(2): 145-152.
Impact Factor: 3.19
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Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Salvatore M
* Tc-99m-MIBI in the evaluation of breast cancer biology (348 visite)
Breast Cancer (ISSN: 9783-540367802), 2004 Jun; 1: 71-81.
Impact Factor: 0.635
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Del Vecchio S, Salvatore M
* Tc-99m-MIBI in the evaluation of breast cancer biology (254 visite) (PDF 103 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2004 Jun; 31(SUPPL.1): S88-S88.
Impact Factor: 3.935
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Esposito G, Vitagliano L, Costanzo P, Borrelli L, Barone R, Pavone L, Izzo P, Zagari A, Salvatore F
* Human aldolase A natural mutants: relationship between flexibility of the C-terminal region and enzyme function (129 visite)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2004 May 15; 380: 51-56.
Impact Factor: 4.278
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Cortesi R, Mischiati C, Borgatti M, Breda L, Romanelli A, Saviano M, Pedone C, Gambari R, Nastruzzi C
* Formulations for natural and peptide nucleic acids based on cationic polymeric submicron particles (191 visite)
The Aaps Journal (ISSN: 1522-1059, 1550-7416), 2004 Jan 20; 6(1): N/D-N/D.
Impact Factor: 1.938
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Aloj L, Zannetti A, Caracó C, Del Vecchio S, Salvatore M
* Bcl-2 overexpression prevents 99mTc-MIBI uptake in breast cancer cell lines (253 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2004; 31(4): 521-527.
Impact Factor: 3.935
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Musumeci D, Roviello GN, Valente M, Sapio R, Pedone C, Bucci EM
* New synthesis of PNA-3′DNA linker monomers, useful building blocks to obtain PNA/DNA chimeras (179 visite)
Biopolymers, 2004; 76(6): 535-542.
Impact Factor: 2.248
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d'Alesio V, Pacelli R, Durante M, Canale Cama G, Cella L, Gialanella G, Grossi G, Pugliese M, Punzo G, Sardi I, Scampoli P, Solla R, Salvatore M
* Lymph nodes in the irradiated field influence the yield of radiation-induced chromosomal aberrations in lymphocytes from breast cancer patients (181 visite)
Int J Radiat Oncol (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2003 Nov 1; 57(3): 732-738.
Impact Factor: 4.285
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Menchise V, De Simone G, Tedeschi T, Corradini R, Sforza S, Marchelli R, Capasso D, Saviano M, Pedone C
* Insights into peptide nucleic acid (PNA) structural features: The crystal structure of a D-lysine-based chiral PNA-DNA duplex (223 visite)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2003 Oct 14; 100(21): 12021-12026.
Impact Factor: 10.272
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Del Vecchio S, Zannetti A, Aloj L, Caracò C, Ciarmiello A, Salvatore M
* Inhibition of early Tc-99m-MIBI uptake by Bcl-2 anti-apoptotic protein overexpression in untreated breast carcinoma (246 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2003 Jun; 30(6): 879-887.
Impact Factor: 3.324
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Lomax AJ, Cella L, Weber D, Kurtz JM, Miralbell R
* Potential role of IMRT and protons in the treatment of the breast and regional nodes (172 visite)
Int J Rad Oncol Biol Phys, 2003 Mar 1; 48(3Supplement): 785-792.
Impact Factor: 0.155
Dettagli Esporta in BibTeX Esporta in EndNote
Del Vecchio S, Zannetti A, Aloj L, Salvatore M
* MIBI as prognostic factor in breast cancer (224 visite)
Q J Nucl Med (ISSN: 1124-3937, 1125-0135), 2003 Mar; 47(1): 46-50.
Impact Factor: 2.222
Dettagli Esporta in BibTeX Esporta in EndNote
Borgatti M, Lampronti I, Romanelli A, Pedone C, Saviano M, Bianchi N, Mischiati C, Gambari R
* Transcription factor decoy molecules based on a peptide nucleic acid (PNA)-DNA chimera mimicking Sp1 binding sites (182 visite)
J Biol Chem (ISSN: 0021-9258, 1083-351x), 2003 Feb 28; 278(9): 7500-7509.
Impact Factor: 6.482
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Pauciullo P, Giannino A, De Michele M, Gentile M, Liguori R, Argiriou A, Carlotto A, Faccenda F, Mancini M, Bond MG, De Simone V, Rubba P
* Increased carotid artery intima-media thickness is associated with a novel mutation of low-density lipoprotein receptor independently of major cardiovascular risk factors (213 visite)
Metab Clin Exp (ISSN: 0026-0495, 1532-8600), 2003; 52(11): 1433-1438.
Impact Factor: 2.013
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Lomax AJ, Cella L, Weber D, Kurtz JM, Miralbell R
* Potential role of intensity-modulated photons and protons in the treatment of the breast and regional nodes (132 visite)
Int J Radiat Oncol (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2003; 55(3): 785-792.
Impact Factor: 4.285
Dettagli Esporta in BibTeX Esporta in EndNote
Borgatti M, Romanelli A, Saviano M, Pedone C, Lampronti I, Breda L, Nastruzzi C, Bianchi N, Mischiati C, Gambari R
* Resistance of decoy PNA-DNA chimeras to enzymatic degradation in cellular extracts and serum (124 visite)
Oncology Research (ISSN: 0965-0407), 2003; 13(5): 279-287.
Impact Factor: 1.794
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Gambari R, Borgatti M, Romanelli A, Capasso D, Saviano M, Bianchi N, Lampronti I, Mischiati C, Pedone C
* Transcription factor decoy (TFD) activity of peptide nucleic acids (PNA)-DNA chimeras (127 visite)
International Journal Of Molecular Medicine (ISSN: 1107-3756), 2003; 12(Supplement1): N/D-N/D.
Impact Factor: 1.94
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Borgatti M, Breda L, Cortesi R, Nastruzzi C, Romanelli A, Saviano M, Bianchi N, Mischiati C, Pedone C, Gambari R
* Cationic Liposomes As Delivery Systems For Double-Stranded Pna-Dna Chimeras Exhibiting Decoy Activity Against Nf-Kappab Transcription Factors (134 visite)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 1873-2968, 0006-2952), 2002 Sep 15; 64(4): 609-616.
Impact Factor: 3.542
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Del Vecchio S, Zannetti A, Ciarmiello A, Aloj L, Caracò C, Fonti R, Botti G, D'Aiuto G, Salvatore M
* Dynamic coupling of Tc-99m-MIBI efflux and apoptotic pathway activation in untreated breast cancer patients (223 visite)
Eur J Nucl Med (ISSN: 1619-7070, 0340-6997, 1619-7089), 2002 Jun; 29(6): 809-814.
Impact Factor: 3.568
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Salvatore M, Fonti R
* New frontiers of nuclear medicine (245 visite)
Tumori (ISSN: 0300-8916, 0300-8916print), 2002 May; 88(3): S60-S60.
Impact Factor: 0.267
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Fonti R, Limite G, Sodano A, Riccardi A, Forestieri P, De Cristofaro G, Pettinato G, Salvatore M
* Sentinel lymph node identification in breast cancer patients (187 visite)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2002 Apr; 103(4): 370-377.
Impact Factor: 1.368
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Menchise V, De Simone G, Corradini R, Sforza S, Sorrentino N, Romanelli A, Saviano M, Pedone C
* Crystallization and preliminary X-ray diffraction studies of a D-lysine-based chiral PNA-DNA duplex (136 visite)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2002 Mar; 58(3): 553-555.
Impact Factor: 1.76
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Zell R, Sidigi K, Bucci E, Stelzner A, Goerlach M
* Determinants of the recognition of enteroviral cloverleaf RNA by coxsackievirus B3 proteinase 3C (171 visite)
Rna (ISSN: 1355-8382), 2002; 8(2): 188-201.
Impact Factor: 5.099
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Danforth Dn JR, Aloj L, Carrasquillo JA, Bacharach SL, Chow C, Zujewski J, Whatley M, Galen B, Merino M, Neumann RD
* The role of 18F-FDG-PET in the local/regional evaluation of women with breast cancer (120 visite)
Breast Cancer Res Tr Kluwer Academic Publishers (ISSN: 0167-6806), 2002; 75(2): 135-146.
Impact Factor: 3.132
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Romanelli A, Pedone C, Saviano M, Bianchi N, Borgatti M, Mischiati C, Gambari R
* Molecular interactions between nuclear factor κB (NF-κB) transcription factors and a PNA-DNA chimera mimicking NF-κB binding sites (147 visite)
Eur J Biochem (ISSN: 0014-2956, 0014-2956print, 0014-2956linking), 2001 Dec; 268(23): 6066-6075.
Impact Factor: 2.849
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Romanelli A, Pedone C, Saviano M, Bianchi N, Borgatti M, Mischiati C, Gambari R
* Molecular interactions with nuclear factor kappaB (NF-kappaB) transcription factors of a PNA-DNA chimera mimicking NF-kappaB binding sites (138 visite)
Eur J Biochem (ISSN: 0014-2956print, 0014-2956linking), 2001 Dec; 268(23): 6066-6075.
Impact Factor: 4.779
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De Falco S, Ruvoletto MG, Verdoliva A, Ruvo M, Raucci A, Marino M, Senatore S, Cassani G, Alberti A, Pontisso P, Fassina G
* Cloning and Expression of a Novel Hepatitis B Virus-binding Protein from HepG2 Cells (207 visite)
J Biol Chem (ISSN: 0021-9258, 1083-351x), 2001 Sep 28; 276(39): 36613-36623.
Impact Factor: 7.258
Dettagli Esporta in BibTeX Esporta in EndNote
Del Vecchio S, Zannetti A, Ciarmiello A, Aloj L, Fonti R, Caraco C, Salvatore M
* 99mTc-MIBI uptake and Bcl-2 overexpression in untreated breast cancer patients (200 visite)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2001 Sep; 28(8): N/D-N/D.
Impact Factor: 3.464
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Aloj L, Zannetti A, Caraco C, Fonti R, Del Vecchio S, Salvatore M
* 99mTc-MIBI uptake in breast cancer cells during early phases of apoptosis induction with Staurosporine (198 visite)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2001 Sep; 28(8): N/D-N/D.
Impact Factor: 3.464
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Aloj L, Del Vecchio S, Zannetti A, Caracò C, Salvatore M
* 99mTc-MIBI uptake is reduced in Bcl-2 overexpressing MCF-7 breast cancer cells (180 visite)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2001 Sep; 28(8): N/D-N/D.
Impact Factor: 3.464
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Imbriaco M, Del Vecchio S, Riccardi A, Pace L, Di Salle F, Di Gennaro F, Salvatore M, Sodano A
* Scintimammography with Tc-99m-MIBI versus dynamic MRI for non-invasive characterization of breast masses (195 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2001 Jan; 28(1): 56-63.
Impact Factor: 3.464
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Saviano M, Romanelli A, Bucci E, Pedone C, Mischiati C, Bianchi N, Feriotto G, Borgatti M, Gambari R
Computational procedures to explain the different biological activity of DNA/DNA, DNA/PNA and PNA/PNA hybrid molecules mimicking NF-κB binding sites (134 visite)
J Biomol Struct Dyn (ISSN: 0739-1102, 1538-0254electronic), 2000 Dec; 18(3): 353-362.
Impact Factor: 1.826
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Del Vecchio S, Ciarmiello A, Zannetti A, Fonti R, Botti G, D'Aiuto G, Salvatore M
Efflux rate of Tc-99m-MIBI and apoptosis in untreated breast cancer patients (202 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2000 May; 41(5): N/D-N/D.
Impact Factor: 3.617
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Aloj L, Del Vecchio S, Damiano M, Borrelli G, Di Gennaro F, Imbriaco M, Panico L, Bifano D, Pettinato G, Salvatore M
Washout of Tc-99m-MIBI and prognostic factors in untreated breast cancer patients (149 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2000 May; 41(5): N/D-N/D.
Impact Factor: 3.617
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Zannetti A, Del Vecchio S, Carriero MV, Fonti R, Franco P, Botti G, D'Aiuto G, Stoppelli MP, Salvatore M
Coordinate up-regulation of Sp1 DNA-binding activity and urokinase receptor expression in breast carcinoma (212 visite)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 2000 Mar 15; 60(6): 1546-1551.
Impact Factor: 8.46
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De Napoli L, De Luca S, Di Fabio G, Messere A, Montesarchio D, Morelli G, Piccialli G, Tesauro D
A facile solid-phase strategy for the synthesis of oligonucleotide- tetraphenylporphyrin conjugates (140 visite)
European Journal Of Organic Chemistry (ISSN: 1434-193x), 2000; (6): 1013-1018.
Impact Factor: 2.15
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Formisano C, Limite G, Lamberti M, Fonti R, Forestieri P
Lymph node mapping and sentinel lymph node biopsy for evaluation of axillary lymph node status in early invasive breast cancer. Our experience (194 visite)
Przegl Lek (ISSN: 0033-2240print, 0033-2240linking), 2000; 57Suppl5: 113-115.
Impact Factor: 0
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Carriero M, Del Vecchio S, Capozzoli M, Franco P, Fontana L, Zannetti A, Botti G, D'Aiuto G, Salvatore M, Stoppelli M
Urokinase receptor interacts with alpha(v)beta(5) vitronectin receptor, promoting urokinase-dependent cell migration in breast cancer (216 visite)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1999 Oct 15; 59(20): N/D-N/D.
Impact Factor: 8.614
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Aloj L, Del Vecchio S, Damiano M, Zannetti A, Di Gennaro F, Imbriaco M, Salvatore M
Fractional retention of 99mTc-MIBI and proliferation in untreated breast cancer (186 visite)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1999 Sep; 26(9): N/D-N/D.
Impact Factor: 3.239
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Salvatore M, Del Vecchio S
Dynamic imaging: Scintimammography (189 visite)
Eur J Radiol Elsevier Sci Ireland Ltd (ISSN: 0720-048x), 1998 May; 27(SUPPL.2): S259-S259.
Impact Factor: 0.537
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Ciarmiello A, Del Vecchio S, Silvestro P, Potena MI, Carriero MV, Thomas R, Botti G, D'Aiuto G, Salvatore M
Tumor clearance of technetium 99m-sestamibi as a predictor of response to neoadjuvant chemotherapy for locally advanced breast cancer (170 visite)
Journal Of Clinical Oncology (ISSN: 0732-183x), 1998 May; 16(5): 1677-1683.
Impact Factor: 8.228
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Mansi L, Rambaldi PF, Cuccurullo V, Pecori B, Quarantelli M, Fallanca F, Del Vecchio E
Diagnostic and prognostic role of 99mTc-Tetrofosmin in breast cancer (140 visite)
Q J Nucl Med (ISSN: 1124-3937, 1125-0135), 1997 Sep; 41(3): 239-250.
Impact Factor: 2.125
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Del Vecchio S, Ciarmiello A, Pace L, Potena MI, Carriero MV, Mainolfi C, Thomas R, D'Aiuto G, Tsuruo T, Salvatore M
Fractional retention of technetium-99m-sestamibi as an index of P- glycoprotein expression in untreated breast cancer patients (145 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1997 Sep; 38(9): 1348-1351.
Impact Factor: 3.491
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Cook JA, Krishna MC, Pacelli R, DeGraff W, Liebmann J, Mitchell JB, Russo A, Wink DA
Nitric oxide enhancement of melphalan-induced cytotoxicity (169 visite)
Br J Cancer (ISSN: 0007-0920, 0007-0920print, 0007-0920linking), 1997 Sep; 76(3): 325-334.
Impact Factor: 2.938
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Carriero MV, Del Vecchio S, Franco P, Potena MI, Chiaradonna F, Botti G, Stoppelli MP, Salvatore M
Vitronectin binding to urokinase receptor in human breast cancer (180 visite)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 1997 Sep; 3(8): 1299-1308.
Impact Factor: 3.419
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Lastoria S, Varrella P, Mainolfi C, Piccolo S, Acampa W, Apicella A, Muto P, Thomas R, DAiuto G, Panico R, Salvatore M
Fluorine-18 PET imaging of primary breast cancer: Preliminary results (95 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1997 May; 38(5SUPPL.): N/D-N/D.
Impact Factor: 3.491
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Vecchio SD, Ciarmiello A, Potena MI, Carriero MV, Mainolfi C, Botti G, Thomas R, Cerra M, D'Aiuto G, Tsuruo T, Salvatore M
In vivo detection of multidrug-resistant (MDR1) phenotype by technetium-99m sestamibi scan in untreated breast cancer patients (157 visite)
Eur J Nucl Med (ISSN: 0340-6997print, 0340-6997linking), 1997 Feb; 24(2): 150-159.
Impact Factor: 5.036
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Lastoria S, Varrella P, Thomas R, DAiuto G, Acampa W, Vergara E, Piccolo S, Muto P, Salvatore M
Planning and monitoring the treatment in breast cancer by scintimammography with Tc-99m MIBI (144 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1996 May; 37(5SUPPL.): N/D-N/D.
Impact Factor: 3.491
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Costanzo LL, De Guidi G, Giuffrida S, Sortino S, Condorelli G, Pappalardo G
Antioxidant effect of copper(II) on photosensitized lipid peroxidation (185 visite)
J Chem Res (ISSN: 0162-0134print, 0162-0134linking, 1873-3344), 1995 Feb; 57(2): 115-125.
Impact Factor: 1.342
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Varrella P, Lastoria S, Vergara E, Acampa W, Maurea S, Salvatore M
Tc-99m MIBI Scintimammography for monitoring tumor response in patients with advanced breast cancer (94 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1995; 36(5SUPPL.): N/D-N/D.
Impact Factor: 3.491
Dettagli Esporta in BibTeX Esporta in EndNote
Carriero MV, Franco P, Del Vecchio S, Massa O, Botti G, D'Aiuto G, Stoppelli MP, Salvatore M
Tissue distribution of soluble and receptor-bound urokinase in human breast cancer using a panel of monoclonal antibodies (183 visite)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1994 Oct 15; 54(20): 5445-5454.
Impact Factor: 8.426
Dettagli Esporta in BibTeX Esporta in EndNote
Del Vecchio S, Stoppelli MP, Carriero MV, Fonti R, Massa O, Li PY, Botti G, Cerra M, D'Aiuto G, Esposito G, Salvatore M
IN-VITRO RECEPTOR IMAGING FOR CHARACTERIZATION OF HUMAN SOLID TUMORS (125 visite)
Nucl Med Biol (ISSN: 0883-2897, 0969-8051), 1994 Jul; 21(5): 771-774.
Impact Factor: 1.042
Dettagli Esporta in BibTeX Esporta in EndNote
Carriero MV, Stoppelli MP, Del Vecchio S, Franco P, Massa O, Fonti R, Salvatore M
Comparative distribution of urokinase receptor and urokinase in human breast cancer (151 visite)
Meetingproceedings Of The American Association For Cancer Research Annual (ISSN: 0197-016x), 1994; 35(0): N/D-N/D.
Impact Factor: 0
Dettagli Esporta in BibTeX Esporta in EndNote
Del Vecchio S, Stoppelli MP, Carriere MV, Fonti R, Massa O, Li PY, Botti G, Cerra M, D'Aiuto G, Esposito G, Salvatore M
Human urokinase receptor concentration in malignant and benign breast tumors by in vitro quantitative autoradiography: Comparison with urokinase levels (129 visite)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1993 Jul 1; 53(13): 3198-3206.
Impact Factor: 8.426
Dettagli Esporta in BibTeX Esporta in EndNote
FRITTITTA L, VIGNERI R, PAPA V, GOLDFINE I, GRASSO G, TRISCHITTA V
Structural and functional studies of insulin receptors in human breast cancer (131 visite)
Breast Cancer Res Tr Kluwer Academic Publishers (ISSN: 0167-6806), 1993; 25(1): 73-82.
Impact Factor: 2.43
Dettagli Esporta in BibTeX Esporta in EndNote
Del Vecchio S, Stoppelli P, Fonti R, Carriero MV, Li P, Salvatore M
Urokinase and urokinase receptor overexpression in breast carcinoma as compared to benign lesions (109 visite)
Meetingproceedings Of The American Association For Cancer Research Annual (ISSN: 0197-016x), 1993; 34(0): N/D-N/D.
Impact Factor: 0
Dettagli Esporta in BibTeX Esporta in EndNote
D'Aiuto G, Del Vecchio S, Mansi L, D'Aprile M, Botti G, Salvatore M
Malignant melanoma of the nipple: A case studied with radiolabeled monoclonal antibody (151 visite)
Tumori (ISSN: 0300-8916, 0300-8916print), 1991 Oct 31; 77(5): 449-451.
Impact Factor: 0.408
Dettagli Esporta in BibTeX Esporta in EndNote
Iaffaioli RV, Frasci G, Tortora G, Ciardiello F, Nuzzo F, Scala S, Pacelli R, Bianco AR
Effect of thymic extract 'thymostimulin' on the incidence of infections and myelotoxicity during adjuvant chemotherapy for breast cancer (117 visite)
Thymus (ISSN: 0165-6090), 1988; 12(2): 69-75.
Impact Factor: 0.643
Dettagli Esporta in BibTeX Esporta in EndNote
Alfano B, Coucourde F, Malgieri F, Ragozzino A
PET/CT and radiotherapy (192 visite)
Q J Nucl Med Mol Imaging, 1980 Oct; 50(1): 4-14.
Impact Factor: 0
Dettagli Esporta in BibTeX Esporta in EndNote
195 Records (166 escludendo Abstract e Conferenze).
Impact factor totale: 660.894 (578.134 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 693.545 (587.042 escludendo Abstract e Conferenze).
Impact factor totale: 660.894 (578.134 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 693.545 (587.042 escludendo Abstract e Conferenze).
Esporta in BibTeX Esporta in EndNote
Ultima modifica di Marco Comerci in data Thursday 19 March 2015, 12:24:55
256 visite. Ultima visita in data Saturday 07 December 2019, 20:45:36
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