Tyrosine phosphorylation of phosphoinositide-dependent kinase 1 by the insulin receptor is necessary for insulin metabolic signaling (239 visite)
Mol Cell Biol (ISSN: 0270-7306, 1098-5549), 2005 Dec; 25(24): 10803-10814.
Tipo di articolo: Journal Article,
Impact factor: 7.093, Impact factor a 5 anni: 5.614
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-28544448231&partnerID=40&md5=1539c0b5e4b18c6076457b1823bea233
Parole chiave: Glucose, Insulin, Insulin Receptor, Phenylalanine, Phosphatidylinositide, Phosphatidylinositol 3 Kinase, Phosphoinositide Dependent Kinase 1, Protein Kinase B, Protein Tyrosine Kinase, Threonine, Unclassified Drug, Amino Acid Substitution, Animal Cell, Article, Carboxy Terminal Sequence, Controlled Study, Enzyme Activation, Gene Deletion, Glucose Metabolism, Glucose Transport, In Vitro Study, Insulin Metabolism, Myoblast, Nonhuman, Priority Journal, Protein Expression, Protein Phosphorylation, Signal Transduction, Cultured, Intracellular Signaling Peptides And Proteins, Phosphoproteins, Protein-Serine-Threonine Kinases, Sequence Deletion,
Affiliazioni:
*** IBB - CNR ***
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Università degli Studi di Napoli Federico II, Naples, Italy
Istituto di Biostrutture e Bioimmagini del CNR, Naples, Italy
Department of Clinical Biochemistry, Glostrup Hospital, DK 2600 Glostrup, Denmark
Mammalian Cell Technology, Novo Nordisk A/S, DK 2880 Bagsvaerd, Denmark
Riferimenti:
Alessi, D.R., Kozlowski, M.T., Weng, Q.P., Morrice, N., Avruch, J., 3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro (1998) Curr. Biol., 8, pp. 69-8
Anderson, K.E., Coadwell, J., Stephens, L.R., Hawkins, P.T., Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B (1998) Curr. Biol., 8, pp. 684-691
Belham, C., Wu, S., Avruch, J., Intracellular signalling: PDK-1-a kinase at the hub of things (1999) Curr. Biol., 9, pp. R93-R96
Cantrell, D.A., Phosphoinositide 3-kinase signalling pathways (2001) J. Cell Sci., 114, pp. 1439-1445
Caruso, M., Miele, C., Oriente, F., Maitan, M.A., Bifulco, G., Andreozzi, F., Condorelli, G., Beguinot, F., In L6 skeletal muscle cells, glucose induces cytosolic translocation of protein kinase C-alpha and transactivates the insulin receptor kinase (1999) J. Biol. Chem., 274, pp. 28637-28644
Caruso, M., Maitan, M.A., Bifulco, G., Miele, C., Vigliotta, G., Oriente, F., Formisano, P., Beguinot, F., Activation and mitochondrial translocation of protein kinase Cδ are necessary for insulin stimulation of pyruvate dehydrogenase complex activity in muscle and liver cells (2001) J. Biol. Chem., 276, pp. 45088-45097
Casamayor, A., Morrice, N.A., Alessi, D.R., Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: Identification of five sites of phosphorylation in vivo (1999) Biochem. J., 342, pp. 287-292
Chou, M.M., Hou, W., Johnson, J., Graham, L.K., Lee, M.H., Chen, C.S., Newton, A.C., Toker, A., Regulation of protein kinase C zeta by PI 3-kinase and PDK-1 (1998) Curr. Biol., 8, pp. 1069-1077
Dong, L.Q., Liu, F., PDK2: The missing piece in the receptor tyrosine kinase signaling pathway puzzle (2005) Am. J. Physiol. Endocrinol. Metab., 289, pp. E187-E196
Dong, L.Q., Zhang, R., Langlais, P., He, H., Clark, M., Zhu, L., Liu, F., Primary structure, tissue distribution, and expression of mouse phosphoinositide-dependent protein kinase-1, a protein kinase that phosphorylates and activates protein kinase C (1999) J. Biol. Chem., 274, pp. 8117-8122
Dutil, E.M., Toker, A., Newton, A.C., Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1) (1998) Curr. Biol., 8, pp. 1366-1375
Fields, G.B., Noble, R.L., Solid phase peptide synthesis utilizing 9-fluorenylmethoxycarbonyl amino acids (1990) Int. J. Pept. Protein Res., 35, pp. 161-214
Filippa, N., Sable, C.L., Hemmings, B.A., Van Obberghen, E., Effect of phosphoinositide-dependent kinase 1 on protein kinase B translocation and its subsequent activation (2000) Mol. Cell. Biol., 20, pp. 5712-5721
Fiory, F., Oriente, F., Miele, C., Romano, C., Trencia, A., Alberobello, A.T., Esposito, I., Formisano, P., Protein kinase C-zeta and protein kinase B regulate distinct steps of insulin endocytosis and intracellular sorting (2004) J. Biol. Chem., 279, pp. 11137-11145
Formisano, P., Oriente, F., Miele, C., Caruso, M., Auricchio, R., Vigliotta, G., Condorelli, G., Beguinot, F., In NIH-3T3 fibroblasts, insulin receptor interaction with specific protein kinase C isoforms controls receptor intracellular routing (1998) J. Biol. Chem., 273, pp. 13197-13202
Formisano, P., Sohn, K.J., Miele, C., Di Finizio, B., Petruzziello, A., Riccardi, G., Beguinot, L., Beguinot, F., Mutation in a conserved motif next to the insulin receptor key autophosphorylation sites de-regulates kinase activity and impairs insulin action (1993) J. Biol. Chem., 268, pp. 5241-5248
Foukas, L.C., Shepherd, P.R., Phosphoinositide 3-kinase: The protein kinase that time forgot (2004) Biochem. Soc. Trans., 32, pp. 330-331
Grillo, S., Gremeaux, T., Casamayor, A., Alessi, D.R., Le Marchand-Brustel, Y., Tanti, J.F., Peroxovanadate induces tyrosine phosphorylation of phosphoinositide- dependent protein kinase-1 potential involvement of src kinase (2000) Eur. J. Biochem., 267, pp. 6642-6649
Hresko, R.C., Murata, H., Mueckler, M., Phosphoinositide-dependent kinase-2 is a distinct protein kinase enriched in a novel cytoskeletal fraction associated with adipocyte plasma membranes (2003) J. Biol. Chem., 278, pp. 21615-21622
Kandel, E.S., Hay, N., The regulation and activities of the multi-functional serine/threonine kinase Akt/PKB (1999) Exp. Cell Res., 253, pp. 210-229
Klippel, A., Reinhard, C., Kavanaugh, W.M., Apell, G., Escobedo, M.A., Williams, L.T., Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways (1996) Mol. Cell. Biol., 16, pp. 4117-4127
Kobayashi, T., Cohen, P., Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2 (1999) Biochem. J., 339, pp. 319-328
Levy-Toledano, R., Taouis, M., Blaettler, D.H., Gorden, P., Taylor, S.I., Insulin-induced activation of phosphatidyl inositol 3-kinase. Demonstration that the p85 subunit binds directly to the COOH terminus of the insulin receptor in intact cells (1994) J. Biol. Chem., 269, pp. 31178-31182
Maegawa, H., McClain, D.A., Freidenberg, G., Olefsky, J.M., Napier, M., Lipari, T., Dull, T.J., Ullrich, A., Properties of a human insulin receptor with a COOH-terminal truncation. II. Truncated receptors have normal kinase activity but are defective in signaling metabolic effects (1988) J. Biol. Chem., 263, pp. 8912-8917
McManus, E.J., Collins, B.J., Ashby, P.R., Prescott, A.R., Murray-Tait, V., Armit, L.J., Arthur, J.S., Alessi, D.R., The in vivo role of PtdIns(3,4,5)P(3) binding to PDK1 PH domain defined by knockin mutation (2004) EMBO J., 23, pp. 2071-2082
More, A., Komander, D., Van Aalten, D.M., Alessi, D.R., PDK1, the master regulator of AGC kinase signal transduction (2004) Semin. Cell Dev. Biol., 15, pp. 161-170
Myers, M.G., Backer, J.M., Siddle, K., White, M.F., The insulin receptor functions normally in Chinese hamster ovary cells after truncation of the C terminus (1991) J. Biol. Chem., 266, pp. 10616-10623
Park, J., Hill, M.M., Hess, D., Brazil, D.P., Hofsteenge, J., Hemmings, B.A., Identification of tyrosine phosphorylation sites on 3-phosphoinositide- dependent protein kinase-1 and their role in regulating kinase activity (2001) J. Biol. Chem., 276, pp. 37459-37471
Prasad, N., Topping, R.S., Zhou, D., Decker, S.J., Oxidative stress and vanadate induce tyrosine phosphorylation of phosphoinositide-dependent kinase 1 (PDK1) (2000) Biochemistry, 39, pp. 6929-6935
Piper, R.C., Hess, L.J., James, D.E., Differential sorting of two glucose transporters expressed in insulin-sensitive cells (1991) Am. J. Physiol., 260, pp. C570-C580
Romanelli, A., Dreisbach, V.C., Blenis, J., Characterization of phosphatidylinositol 3-kinase-dependent phosphorylation of the hydrophobic motif site Thr(389) in p70 S6 kinase 1 (2002) J. Biol. Chem., 277, pp. 40281-40289
Ruderman, N.B., Kapeller, R., White, M.F., Cantley, L.C., Activation of phosphatidylinositol 3-kinase by insulin (1990) Proc. Natl. Acad. Sci. USA, 87, pp. 1411-1415
Sakaue, H., Nishizawa, A., Ogawa, W., Teshigawara, K., Mori, T., Takashima, Y., Noda, T., Kasuga, M., Requirement for 3-phosphoinositide-dependent kinase-1 (PDK-1) in insulin-induced glucose uptake in immortalized brown adipocytes (2003) J. Biol. Chem., 278, pp. 38870-38874
Sarbassov, D.D., Guertin, D.A., Ali, S.M., Sabatini, D.M., Phosphorylation and regulation of Akt/PKB by the Rictor-mTOR complex (2005) Science, 307, pp. 1098-1101
Simpson, I.A., Yver, D.R., Hissin, P.J., Wardzala, L.J., Karnieli, E., Salans, L.B., Cushman, S.W., Insulin-stimulated translocation of glucose transporters in the isolated rat adipose cells: Characterization of subcellular fractions (1983) Biochim. Biophys. Acta, 763, pp. 393-407
Storz, P., Toker, A., 3′-Phosphoinositide-dependent kinase-1 (PDK-1) in PI 3-kinase signaling (2002) Front Biosci., 7, pp. 886-902
Vanhaesebroeck, B., Alessi, D.R., The PI3K-PDK1 connection: More than just a road to PKB (2000) Biochem. J., 346, pp. 561-576
Van Horn, D.J., Myers Jr., M.G., Backer, J.M., Direct activation of the phosphatidylinositol 3′-kinase by the insulin receptor (1994) J. Biol. Chem., 269, pp. 29-32
Vigliotta, G., Miele, C., Santopietro, S., Portella, G., Perfetti, A., Maitan, M.A., Cassese, A., Beguinot, F., Overexpression of the ped/pea-15 gene causes diabetes by impairing glucose-stimulated insulin secretion in addition to insulin action (2004) Mol. Cell. Biol., 24, pp. 5005-5015
Wei, Q., Xia, Y., Roles of 3-phosphoinositide-dependent kinase 1 in the regulation of endothelial nitric-oxide synthase phosphorylation and function by heat shock protein 90 (2005) J. Biol. Chem., 280, pp. 18081-18086
Wick, K.L., Liu, F., A new molecular target of insulin action: Regulating the pivotal PDK1 (2001) Curr. Drug Targets Immune Endocr. Metabol. Disord., 1, pp. 209-221
Williams, M.R., Arthur, J.S., Balendran, A., Van Der Kaay, J., Poli, V., Cohen, P., Alessi, D.R., The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells (2000) Curr. Biol., 10, pp. 439-448
Alessi, D. R., Kozlowski, M. T., Weng, Q. P., Morrice, N., Avruch, J., 3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro (1998) Curr. Biol., 8, pp. 69-8
Anderson, K. E., Coadwell, J., Stephens, L. R., Hawkins, P. T., Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B (1998) Curr. Biol., 8, pp. 684-691
Cantrell, D. A., Phosphoinositide 3-kinase signalling pathways (2001) J. Cell Sci., 114, pp. 1439-1445
Chou, M. M., Hou, W., Johnson, J., Graham, L. K., Lee, M. H., Chen, C. S., Newton, A. C., Toker, A., Regulation of protein kinase C zeta by PI 3-kinase and PDK-1 (1998) Curr. Biol., 8, pp. 1069-1077
Dong, L. Q., Liu, F., PDK2: The missing piece in the receptor tyrosine kinase signaling pathway puzzle (2005) Am. J. Physiol. Endocrinol. Metab., 289, pp. E187-E196
Dong, L. Q., Zhang, R., Langlais, P., He, H., Clark, M., Zhu, L., Liu, F., Primary structure, tissue distribution, and expression of mouse phosphoinositide-dependent protein kinase-1, a protein kinase that phosphorylates and activates protein kinase C (1999) J. Biol. Chem., 274, pp. 8117-8122
Dutil, E. M., Toker, A., Newton, A. C., Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1) (1998) Curr. Biol., 8, pp. 1366-1375
Fields, G. B., Noble, R. L., Solid phase peptide synthesis utilizing 9-fluorenylmethoxycarbonyl amino acids (1990) Int. J. Pept. Protein Res., 35, pp. 161-214
Foukas, L. C., Shepherd, P. R., Phosphoinositide 3-kinase: The protein kinase that time forgot (2004) Biochem. Soc. Trans., 32, pp. 330-331
Hresko, R. C., Murata, H., Mueckler, M., Phosphoinositide-dependent kinase-2 is a distinct protein kinase enriched in a novel cytoskeletal fraction associated with adipocyte plasma membranes (2003) J. Biol. Chem., 278, pp. 21615-21622
Kandel, E. S., Hay, N., The regulation and activities of the multi-functional serine/threonine kinase Akt/PKB (1999) Exp. Cell Res., 253, pp. 210-229
McManus, E. J., Collins, B. J., Ashby, P. R., Prescott, A. R., Murray-Tait, V., Armit, L. J., Arthur, J. S., Alessi, D. R., The in vivo role of PtdIns (3, 4, 5) P (3) binding to PDK1 PH domain defined by knockin mutation (2004) EMBO J., 23, pp. 2071-2082
Myers, M. G., Backer, J. M., Siddle, K., White, M. F., The insulin receptor functions normally in Chinese hamster ovary cells after truncation of the C terminus (1991) J. Biol. Chem., 266, pp. 10616-10623
Park, J., Hill, M. M., Hess, D., Brazil, D. P., Hofsteenge, J., Hemmings, B. A., Identification of tyrosine phosphorylation sites on 3-phosphoinositide- dependent protein kinase-1 and their role in regulating kinase activity (2001) J. Biol. Chem., 276, pp. 37459-37471
Piper, R. C., Hess, L. J., James, D. E., Differential sorting of two glucose transporters expressed in insulin-sensitive cells (1991) Am. J. Physiol., 260, pp. C570-C580
Ruderman, N. B., Kapeller, R., White, M. F., Cantley, L. C., Activation of phosphatidylinositol 3-kinase by insulin (1990) Proc. Natl. Acad. Sci. USA, 87, pp. 1411-1415
Sarbassov, D. D., Guertin, D. A., Ali, S. M., Sabatini, D. M., Phosphorylation and regulation of Akt/PKB by the Rictor-mTOR complex (2005) Science, 307, pp. 1098-1101
Simpson, I. A., Yver, D. R., Hissin, P. J., Wardzala, L. J., Karnieli, E., Salans, L. B., Cushman, S. W., Insulin-stimulated translocation of glucose transporters in the isolated rat adipose cells: Characterization of subcellular fractions (1983) Biochim. Biophys. Acta, 763, pp. 393-407
Van Horn, D. J., Myers Jr., M. G., Backer, J. M., Direct activation of the phosphatidylinositol 3 -kinase by the insulin receptor (1994) J. Biol. Chem., 269, pp. 29-32
Wick, K. L., Liu, F., A new molecular target of insulin action: Regulating the pivotal PDK1 (2001) Curr. Drug Targets Immune Endocr. Metabol. Disord., 1, pp. 209-221
Williams, M. R., Arthur, J. S., Balendran, A., Van Der Kaay, J., Poli, V., Cohen, P., Alessi, D. R., The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells (2000) Curr. Biol., 10, pp. 439-448
Mol Cell Biol (ISSN: 0270-7306, 1098-5549), 2005 Dec; 25(24): 10803-10814.
Tipo di articolo: Journal Article,
Impact factor: 7.093, Impact factor a 5 anni: 5.614
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-28544448231&partnerID=40&md5=1539c0b5e4b18c6076457b1823bea233
Parole chiave: Glucose, Insulin, Insulin Receptor, Phenylalanine, Phosphatidylinositide, Phosphatidylinositol 3 Kinase, Phosphoinositide Dependent Kinase 1, Protein Kinase B, Protein Tyrosine Kinase, Threonine, Unclassified Drug, Amino Acid Substitution, Animal Cell, Article, Carboxy Terminal Sequence, Controlled Study, Enzyme Activation, Gene Deletion, Glucose Metabolism, Glucose Transport, In Vitro Study, Insulin Metabolism, Myoblast, Nonhuman, Priority Journal, Protein Expression, Protein Phosphorylation, Signal Transduction, Cultured, Intracellular Signaling Peptides And Proteins, Phosphoproteins, Protein-Serine-Threonine Kinases, Sequence Deletion,
Affiliazioni:
*** IBB - CNR ***
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Università degli Studi di Napoli Federico II, Naples, Italy
Istituto di Biostrutture e Bioimmagini del CNR, Naples, Italy
Department of Clinical Biochemistry, Glostrup Hospital, DK 2600 Glostrup, Denmark
Mammalian Cell Technology, Novo Nordisk A/S, DK 2880 Bagsvaerd, Denmark
Riferimenti:
Alessi, D.R., Kozlowski, M.T., Weng, Q.P., Morrice, N., Avruch, J., 3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro (1998) Curr. Biol., 8, pp. 69-8
Anderson, K.E., Coadwell, J., Stephens, L.R., Hawkins, P.T., Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B (1998) Curr. Biol., 8, pp. 684-691
Belham, C., Wu, S., Avruch, J., Intracellular signalling: PDK-1-a kinase at the hub of things (1999) Curr. Biol., 9, pp. R93-R96
Cantrell, D.A., Phosphoinositide 3-kinase signalling pathways (2001) J. Cell Sci., 114, pp. 1439-1445
Caruso, M., Miele, C., Oriente, F., Maitan, M.A., Bifulco, G., Andreozzi, F., Condorelli, G., Beguinot, F., In L6 skeletal muscle cells, glucose induces cytosolic translocation of protein kinase C-alpha and transactivates the insulin receptor kinase (1999) J. Biol. Chem., 274, pp. 28637-28644
Caruso, M., Maitan, M.A., Bifulco, G., Miele, C., Vigliotta, G., Oriente, F., Formisano, P., Beguinot, F., Activation and mitochondrial translocation of protein kinase Cδ are necessary for insulin stimulation of pyruvate dehydrogenase complex activity in muscle and liver cells (2001) J. Biol. Chem., 276, pp. 45088-45097
Casamayor, A., Morrice, N.A., Alessi, D.R., Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: Identification of five sites of phosphorylation in vivo (1999) Biochem. J., 342, pp. 287-292
Chou, M.M., Hou, W., Johnson, J., Graham, L.K., Lee, M.H., Chen, C.S., Newton, A.C., Toker, A., Regulation of protein kinase C zeta by PI 3-kinase and PDK-1 (1998) Curr. Biol., 8, pp. 1069-1077
Dong, L.Q., Liu, F., PDK2: The missing piece in the receptor tyrosine kinase signaling pathway puzzle (2005) Am. J. Physiol. Endocrinol. Metab., 289, pp. E187-E196
Dong, L.Q., Zhang, R., Langlais, P., He, H., Clark, M., Zhu, L., Liu, F., Primary structure, tissue distribution, and expression of mouse phosphoinositide-dependent protein kinase-1, a protein kinase that phosphorylates and activates protein kinase C (1999) J. Biol. Chem., 274, pp. 8117-8122
Dutil, E.M., Toker, A., Newton, A.C., Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1) (1998) Curr. Biol., 8, pp. 1366-1375
Fields, G.B., Noble, R.L., Solid phase peptide synthesis utilizing 9-fluorenylmethoxycarbonyl amino acids (1990) Int. J. Pept. Protein Res., 35, pp. 161-214
Filippa, N., Sable, C.L., Hemmings, B.A., Van Obberghen, E., Effect of phosphoinositide-dependent kinase 1 on protein kinase B translocation and its subsequent activation (2000) Mol. Cell. Biol., 20, pp. 5712-5721
Fiory, F., Oriente, F., Miele, C., Romano, C., Trencia, A., Alberobello, A.T., Esposito, I., Formisano, P., Protein kinase C-zeta and protein kinase B regulate distinct steps of insulin endocytosis and intracellular sorting (2004) J. Biol. Chem., 279, pp. 11137-11145
Formisano, P., Oriente, F., Miele, C., Caruso, M., Auricchio, R., Vigliotta, G., Condorelli, G., Beguinot, F., In NIH-3T3 fibroblasts, insulin receptor interaction with specific protein kinase C isoforms controls receptor intracellular routing (1998) J. Biol. Chem., 273, pp. 13197-13202
Formisano, P., Sohn, K.J., Miele, C., Di Finizio, B., Petruzziello, A., Riccardi, G., Beguinot, L., Beguinot, F., Mutation in a conserved motif next to the insulin receptor key autophosphorylation sites de-regulates kinase activity and impairs insulin action (1993) J. Biol. Chem., 268, pp. 5241-5248
Foukas, L.C., Shepherd, P.R., Phosphoinositide 3-kinase: The protein kinase that time forgot (2004) Biochem. Soc. Trans., 32, pp. 330-331
Grillo, S., Gremeaux, T., Casamayor, A., Alessi, D.R., Le Marchand-Brustel, Y., Tanti, J.F., Peroxovanadate induces tyrosine phosphorylation of phosphoinositide- dependent protein kinase-1 potential involvement of src kinase (2000) Eur. J. Biochem., 267, pp. 6642-6649
Hresko, R.C., Murata, H., Mueckler, M., Phosphoinositide-dependent kinase-2 is a distinct protein kinase enriched in a novel cytoskeletal fraction associated with adipocyte plasma membranes (2003) J. Biol. Chem., 278, pp. 21615-21622
Kandel, E.S., Hay, N., The regulation and activities of the multi-functional serine/threonine kinase Akt/PKB (1999) Exp. Cell Res., 253, pp. 210-229
Klippel, A., Reinhard, C., Kavanaugh, W.M., Apell, G., Escobedo, M.A., Williams, L.T., Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways (1996) Mol. Cell. Biol., 16, pp. 4117-4127
Kobayashi, T., Cohen, P., Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2 (1999) Biochem. J., 339, pp. 319-328
Levy-Toledano, R., Taouis, M., Blaettler, D.H., Gorden, P., Taylor, S.I., Insulin-induced activation of phosphatidyl inositol 3-kinase. Demonstration that the p85 subunit binds directly to the COOH terminus of the insulin receptor in intact cells (1994) J. Biol. Chem., 269, pp. 31178-31182
Maegawa, H., McClain, D.A., Freidenberg, G., Olefsky, J.M., Napier, M., Lipari, T., Dull, T.J., Ullrich, A., Properties of a human insulin receptor with a COOH-terminal truncation. II. Truncated receptors have normal kinase activity but are defective in signaling metabolic effects (1988) J. Biol. Chem., 263, pp. 8912-8917
McManus, E.J., Collins, B.J., Ashby, P.R., Prescott, A.R., Murray-Tait, V., Armit, L.J., Arthur, J.S., Alessi, D.R., The in vivo role of PtdIns(3,4,5)P(3) binding to PDK1 PH domain defined by knockin mutation (2004) EMBO J., 23, pp. 2071-2082
More, A., Komander, D., Van Aalten, D.M., Alessi, D.R., PDK1, the master regulator of AGC kinase signal transduction (2004) Semin. Cell Dev. Biol., 15, pp. 161-170
Myers, M.G., Backer, J.M., Siddle, K., White, M.F., The insulin receptor functions normally in Chinese hamster ovary cells after truncation of the C terminus (1991) J. Biol. Chem., 266, pp. 10616-10623
Park, J., Hill, M.M., Hess, D., Brazil, D.P., Hofsteenge, J., Hemmings, B.A., Identification of tyrosine phosphorylation sites on 3-phosphoinositide- dependent protein kinase-1 and their role in regulating kinase activity (2001) J. Biol. Chem., 276, pp. 37459-37471
Prasad, N., Topping, R.S., Zhou, D., Decker, S.J., Oxidative stress and vanadate induce tyrosine phosphorylation of phosphoinositide-dependent kinase 1 (PDK1) (2000) Biochemistry, 39, pp. 6929-6935
Piper, R.C., Hess, L.J., James, D.E., Differential sorting of two glucose transporters expressed in insulin-sensitive cells (1991) Am. J. Physiol., 260, pp. C570-C580
Romanelli, A., Dreisbach, V.C., Blenis, J., Characterization of phosphatidylinositol 3-kinase-dependent phosphorylation of the hydrophobic motif site Thr(389) in p70 S6 kinase 1 (2002) J. Biol. Chem., 277, pp. 40281-40289
Ruderman, N.B., Kapeller, R., White, M.F., Cantley, L.C., Activation of phosphatidylinositol 3-kinase by insulin (1990) Proc. Natl. Acad. Sci. USA, 87, pp. 1411-1415
Sakaue, H., Nishizawa, A., Ogawa, W., Teshigawara, K., Mori, T., Takashima, Y., Noda, T., Kasuga, M., Requirement for 3-phosphoinositide-dependent kinase-1 (PDK-1) in insulin-induced glucose uptake in immortalized brown adipocytes (2003) J. Biol. Chem., 278, pp. 38870-38874
Sarbassov, D.D., Guertin, D.A., Ali, S.M., Sabatini, D.M., Phosphorylation and regulation of Akt/PKB by the Rictor-mTOR complex (2005) Science, 307, pp. 1098-1101
Simpson, I.A., Yver, D.R., Hissin, P.J., Wardzala, L.J., Karnieli, E., Salans, L.B., Cushman, S.W., Insulin-stimulated translocation of glucose transporters in the isolated rat adipose cells: Characterization of subcellular fractions (1983) Biochim. Biophys. Acta, 763, pp. 393-407
Storz, P., Toker, A., 3′-Phosphoinositide-dependent kinase-1 (PDK-1) in PI 3-kinase signaling (2002) Front Biosci., 7, pp. 886-902
Vanhaesebroeck, B., Alessi, D.R., The PI3K-PDK1 connection: More than just a road to PKB (2000) Biochem. J., 346, pp. 561-576
Van Horn, D.J., Myers Jr., M.G., Backer, J.M., Direct activation of the phosphatidylinositol 3′-kinase by the insulin receptor (1994) J. Biol. Chem., 269, pp. 29-32
Vigliotta, G., Miele, C., Santopietro, S., Portella, G., Perfetti, A., Maitan, M.A., Cassese, A., Beguinot, F., Overexpression of the ped/pea-15 gene causes diabetes by impairing glucose-stimulated insulin secretion in addition to insulin action (2004) Mol. Cell. Biol., 24, pp. 5005-5015
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In L6 myoblasts, insulin receptors with deletion of the C-terminal 43 amino acids (IR Δ43) exhibited normal autophosphorylation and IRS-1/2 tyrosine phosphorylation. The L6 cells expressing IR Δ43 (L6 IRΔ43) also showed no inselin effect on glucose uptake and glycogen synthase, accompanied by a >80% decrease in insulin induction of 3-phosphoinositide-dependent protein kinase 1 (PDK-1) activity and tyrosine phosphorylation and of protein kinase B (PKB) phosphorylation at Thr 308. Insulin induced the phosphatidylinositol 3 kinase-dependent coprecipitation of PDK-1 with wild-type IR (IR WT), but not IR Δ43. Based on overlay blotting, PDK-1 directly bound IR WT, but not IR Δ43. Insulin-activated IR WT, and not IR Δ43, phosphorylated PDK-1 at tyrosines 9, 373, and 376. The IR C-terminal 43-amino-acid peptide (C-terminal peptide) inhibited in vitro PDK-1 tyrosine phosphorylation by the IR. Tyr→Phe substitution prevented this inhibitory action. In the L6 hIR cells, the C-terminal peptide coprecipitated with PDK-1 in an insulin-stimulated fashion. This peptide simultaneously impaired the insulin effect on PDK-1 coprecipitation with IR WT, on PDK-1 tyrosine phosphorylation, on PKB phosphorylation at Thr 308, and on glucose uptake. Upon insulin exposure, PDK-1 membrane persistence was significantly reduced in L6 IRΔ43 compared to control cells. In L6 cells expressing IR WT, the C-terminal peptide also impaired insulin-dependent PDK-1 membrane persistence. Thus, PDK-1 directly binds to the insulin receptor, followed by PDK-1 activation and insulin metabolic effects. Copyright © 2005, American Society for Microbiology. All Rights Reserved.
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Impact Factor: 1.724
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Cucinotta V, Giuffrida A, Grasso G, Maccarrone G, Messina M, Vecchio G
* High selectivity in new chiral separations of dansyl amino acids by cyclodextrin derivatives in electrokinetic chromatography (160 visite)
J Chromatogr A (ISSN: 0021-9673), 2007; 1155(2): 172-179.
Impact Factor: 3.641
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Menchise V, De Simone G, Di Fiore A, Scozzafava A, Supuran CT
* Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of 5-amino-1, 3, 4-thiadiazole-2-sulfonamide and 5-(4-amino-3-chloro-5-fluorophenylsulfonamido)1, 3, 4-thiadiazole-2-sulfon amide to human isoform II (143 visite)
Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2006 Dec 15; 16(24): 6204-6208.
Impact Factor: 2.538
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De Simone G, Vitale RM, Di Fiore A, Pedone C, Scozzafava A, Montero JL, Winum JY, Supuran CT
* Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX (183 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Sep 7; 49(18): 5544-5551.
Impact Factor: 5.115
Dettagli Esporta in BibTeX Esporta in EndNote
Alterio V, Vitale RM, Monti SM, Pedone C, Scozzafava A, Cecchi A, De Simone G, Supuran CT
* Carbonic anhydrase inhibitors: X-ray and molecular modeling study for the interaction of a fluorescent antitumor sulfonamide with isozyme II and IX (168 visite)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2006 Jun 28; 128(25): 8329-8335.
Impact Factor: 7.696
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De Capua A, Goodman M, Amino Y, Saviano M, Benedetti E
* Conformation analysis of aspartame-based sweeteners by NMR spectroscopy, molecular dynamics simulations, and X-ray diffraction studies (318 visite)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2006 Feb; 7(2): 377-387.
Impact Factor: 4.1
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Cittadini A, Monti MG, Iaccarino G, Di Rella F, Tsichlis PN, Di Gianni A, Strömer H, Sorriento D, Peschle C, Trimarco B, Saccà L, Condorelli G
* Adenoviral gene transfer of Akt enhances myocardial contractility and intracellular calcium handling (161 visite)
Gene Ther (ISSN: 0969-7128, 0969-7128linking), 2006; 13(1): 8-19.
Impact Factor: 4.782
Dettagli Esporta in BibTeX Esporta in EndNote
Menchise V, De Simone G, Alterio V, Di Fiore A, Pedone C, Scozzafava A, Supuran CT
* Carbonic anhydrase inhibitors: Stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II (205 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2005 Sep 8; 48(18): 5721-5727.
Impact Factor: 4.926
Dettagli Esporta in BibTeX Esporta in EndNote
La Mendola D, Bonomo RP, Impellizzeri G, Maccarrone G, Pappalardo G, Pietropaolo A, Rizzarelli E, Zito V
* Copper(II) complexes with chicken prion repeats: Influence of proline and tyrosine residues on the coordination features (145 visite)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2005 Sep; 10(5): 463-475.
Impact Factor: 3.224
Dettagli Esporta in BibTeX Esporta in EndNote
Foti D, Chiefari E, Fedele M, Iuliano R, Brunetti L, Paonessa F, Manfioletti G, Barbetti F, Brunetti A, Croce CM, Fusco A, Brunetti A
* Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice (158 visite)
Nat Med (ISSN: 1078-8956, 0034-7264), 2005 Jul; 11(7): 765-773.
Impact Factor: 28.878
Dettagli Esporta in BibTeX Esporta in EndNote
La Rosa C, Milardi D, Amato E, Pappalardo M, Grasso D
* Molecular mechanism of the inhibition of cytochrome c aggregation by Phe-Gly (253 visite)
Arch Biochem Biophys (ISSN: 0003-9861), 2005 Mar 1; 435(1): 182-189.
Impact Factor: 3.152
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Iaccarino G, Ciccarelli M, Sorriento D, Galasso G, Campanile A, Santulli G, Cipolletta E, Cerullo V, Cimini V, Altobelli GG, Piscione F, Priante O, Pastore L, Chiariello M, Salvatore F, Koch WJ, Trimarco B
* Ischemic neoangiogenesis enhanced by β2-adrenergic receptor overexpression: A novel role for the endothelial adrenergic system (178 visite)
Circ Res (ISSN: 0009-7330, 1524-4571electronic), 2005; 97(11): 1182-1189.
Impact Factor: 9.408
Dettagli Esporta in BibTeX Esporta in EndNote
Saviano M, Improta R, Benedetti E, Carrozzini B, Cascarano GL, Didierjean C, Toniolo C, Crisma M
* Benzophenone photophore flexibility and proximity: Molecular and crystal-state structure of a Bpa-containing trichogin dodecapeptide analogue (180 visite)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2004 Apr 2; 5(4): 541-544.
Impact Factor: 3.474
Dettagli Esporta in BibTeX Esporta in EndNote
Cucinotta V, Giuffrida A, La Mendola D, Maccarrone G, Puglisi A, Rizzarelli E, Vecchio G
* 3-Amino Derivative Of Beta-Cyclodextrin: Thermodynamics Of Copper (ii) Complexes And Exploitation Of Its Enantioselectivity In The Separation Of Amino Acid Racemates By Ligand Exchange Capillary Electrophoresis (175 visite)
And Life Sciencesjournal Of Chromatography B Analytical Technologies In The Biomedical, 2004 Feb 5; 800(1-2): 127-133.
Impact Factor: 1.403
Dettagli Esporta in BibTeX Esporta in EndNote
Iaccarino G, Ciccarelli M, Sorriento D, Cipolletta E, Cerullo V, Iovino GL, Paudice A, Elia A, Santulli G, Campanile A, Arcucci O, Pastore L, Salvatore F, Condorelli G, Trimarco B
* AKT participates in endothelial dysfunction in hypertension (144 visite)
Circulationcirculation (ISSN: 0009-7322), 2004; 109(21): 2587-2593.
Impact Factor: 12.563
Dettagli Esporta in BibTeX Esporta in EndNote
Mansi R, Tesauro D, De Capua A, Fattorusso R, Carac C, Aloj L, Benedetti E, Morelli G
* Peptide-chelating agent conjugate for selective targeting of somatostatin receptor type 1: Synthesis and characterization (238 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 527-534.
Impact Factor: 2.863
Dettagli Esporta in BibTeX Esporta in EndNote
Spalletti-cernia D, Sorrentino R, Di Gaetano S, Arciello A, Garbi C, Piccoli R, D'Alessio G, Vecchio G, Laccetti P, Santoro M
* Antineoplastic ribonucleases selectively kill thyroid carcinoma cells via caspase-mediated induction of apoptosis (169 visite)
Journal Of Clinical Endocrinology & Metabolism (ISSN: 0021-972x), 2003 Jun; 88(6): 2900-2907.
Impact Factor: 5.873
Dettagli Esporta in BibTeX Esporta in EndNote
Palladino P, Pedone C, Ragone R, Rossi F, Saviano M, Benedetti E
* A simplified model of the binding interaction between stromal cell-derived factor-1 chemokine and CXC chemokine receptor (190 visite)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2003 Apr; 10(2): 133-138.
Impact Factor: 0.46
Dettagli Esporta in BibTeX Esporta in EndNote
Palladino P, De Capua A, Pedone C, Ragone R, Rossi F, Limatola C, Ragozzino D, Benedetti E
* A simplified model of the interaction between SDF-1 chemokine and the CXCR4 receptor (196 visite)
Peptide Revolution, 2003 Apr; 10(2): 133-138.
Impact Factor: 4.659
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Meyer Lindenberg A, Miletich RS, Kohn PD, Esposito G, Carson RE, Quarantelli M, Weinberger DR, Berman KF
* Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia (285 visite)
Nat Neurosci (ISSN: 1097-6256), 2002 Mar; 5(3): 267-271.
Impact Factor: 14.857
Dettagli Esporta in BibTeX Esporta in EndNote
Lauceri R, Raudino A, Scolaro LM, Micali N, Purrello R
* From achiral porphyrins to template-imprinted chiral aggregates and further. Self-replication of chiral memory from scratch (196 visite)
J Am Chem Soc (ISSN: 0002-7863print, 0002-7863linking, 1520-5126electronic), 2002 Feb 13; 120(47): 894-895.
Impact Factor: 9.023
Dettagli Esporta in BibTeX Esporta in EndNote
Maccarrone G, Nardin G, Randaccio L, Tabbì G, Rosi M, Sgamellotti A, Rizzarelli E, Zangrando E
Structure Of Copper(ii) Complexes With L-Leucyl-D-Phenylalanine Or L-Leucyl-L-Phenylalanine And Lcao-Scf-Mo Calculations On The Stabilization Of Copper(ii) Complexes Due To D-π Interaction With Aromatic Ring (161 visite)
Dalton Trans, 1996; N/D: 3449-3453.
Impact Factor: 0
Dettagli Esporta in BibTeX Esporta in EndNote
Bonomo RP, De Flora A, Rizzarelli E, Santoro AM, Tabbì G, Tonetti M
Copper(II) complexes encapsulated in human red blood cells (200 visite)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1995 Sep; 59(4): 773-784.
Impact Factor: 1.342
Dettagli Esporta in BibTeX Esporta in EndNote
FRITTITTA L, VIGNERI R, PAPA V, GOLDFINE I, GRASSO G, TRISCHITTA V
Structural and functional studies of insulin receptors in human breast cancer (134 visite)
Breast Cancer Res Tr Kluwer Academic Publishers (ISSN: 0167-6806), 1993; 25(1): 73-82.
Impact Factor: 2.43
Dettagli Esporta in BibTeX Esporta in EndNote
Papa V, Reese CC, Brunetti A, Vigneri R, Siiteri PK, Goldfine ID
Progestins increase insulin receptor content and insulin stimulation of growth in human breast carcinoma cells (110 visite)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1990 Dec 15; 50(24): 7858-7862.
Impact Factor: 8.426
Dettagli Esporta in BibTeX Esporta in EndNote
Trischitta V, Brunetti A, Chiavetta A, Benzi L, Papa V, Vigneri R
Defects in insulin-receptor internalization and processing in monocytes of obese subjects and obese NIDDM patients (115 visite)
Diabetesdiabetes (ISSN: 0012-1797), 1989 Dec; 38(12): 1579-1584.
Impact Factor: 8.675
Dettagli Esporta in BibTeX Esporta in EndNote
Pezzino V, Papa V, Trischitta V, Brunetti A, Goodman PA, Treutelaar MK, Williams JA, Maddux BA, Vigneri R, Goldfine ID
Human insulin receptor radioimmunoassay: Applicability to insulin-resistant states (112 visite)
Am J Physiol Endocrinol Metab (ISSN: 0002-9513), 1989 Sep; 257(3): N/D-N/D.
Impact Factor: 3.116
Dettagli Esporta in BibTeX Esporta in EndNote
Trischitta V, Wong KY, Brunetti A, Scalisi R, Vigneri R, Goldfine ID
Endocytosis, recycling, and degradation of the insulin receptor. Studies with monoclonal antireceptor antibodies that do not activate receptor kinase (118 visite)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 1989 Mar 25; 264(9): 5041-5046.
Impact Factor: 6.963
Dettagli Esporta in BibTeX Esporta in EndNote
Marletta F, Rizzarelli E, Mangiameli A, Brogna A, Sammartano S, Monaco S, Blasi A
Effects of graded doses of copper complexes of L-aminoacids on gastric acid secretion in rats (174 visite)
Boll Soc Ital Biol Sper (ISSN: 0037-8771), 1979 Apr 30; 55(8): 769-775.
Impact Factor: 0
Dettagli Esporta in BibTeX Esporta in EndNote
72 Records (68 escludendo Abstract e Conferenze).
Impact factor totale: 393.422 (379.952 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 403.297 (396.678 escludendo Abstract e Conferenze).
Impact factor totale: 393.422 (379.952 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 403.297 (396.678 escludendo Abstract e Conferenze).
Esporta in BibTeX Esporta in EndNote
Ultima modifica di Marco Comerci in data Thursday 19 March 2015, 13:15:00
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