Tyrosine phosphorylation of phosphoinositide-dependent kinase 1 by the insulin receptor is necessary for insulin metabolic signaling (439 views visite)
Mol Cell Biol (ISSN: 0270-7306, 1098-5549), 2005 Dec; 25(24): 10803-10814.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article,
Impact factor: 7.093, 5-year impact factor Impact factor a 5 anni: 5.614
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-28544448231&partnerID=40&md5=1539c0b5e4b18c6076457b1823bea233
Keywords Parole chiave: Glucose, Insulin, Insulin Receptor, Phenylalanine, Phosphatidylinositide, Phosphatidylinositol 3 Kinase, Phosphoinositide Dependent Kinase 1, Protein Kinase B, Protein Tyrosine Kinase, Threonine, Unclassified Drug, Amino Acid Substitution, Animal Cell, Article, Carboxy Terminal Sequence, Controlled Study, Enzyme Activation, Gene Deletion, Glucose Metabolism, Glucose Transport, In Vitro Study, Insulin Metabolism, Myoblast, Nonhuman, Priority Journal, Protein Expression, Protein Phosphorylation, Signal Transduction, Cultured, Intracellular Signaling Peptides And Proteins, Phosphoproteins, Protein-Serine-Threonine Kinases, Sequence Deletion,
Affiliations Affiliazioni:
*** IBB - CNR ***
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Università degli Studi di Napoli Federico II, Naples, Italy
Istituto di Biostrutture e Bioimmagini del CNR, Naples, Italy
Department of Clinical Biochemistry, Glostrup Hospital, DK 2600 Glostrup, Denmark
Mammalian Cell Technology, Novo Nordisk A/S, DK 2880 Bagsvaerd, Denmark
References Riferimenti:
Alessi, D.R., Kozlowski, M.T., Weng, Q.P., Morrice, N., Avruch, J., 3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro (1998) Curr. Biol., 8, pp. 69-8
Anderson, K.E., Coadwell, J., Stephens, L.R., Hawkins, P.T., Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B (1998) Curr. Biol., 8, pp. 684-691
Belham, C., Wu, S., Avruch, J., Intracellular signalling: PDK-1-a kinase at the hub of things (1999) Curr. Biol., 9, pp. R93-R96
Cantrell, D.A., Phosphoinositide 3-kinase signalling pathways (2001) J. Cell Sci., 114, pp. 1439-1445
Caruso, M., Miele, C., Oriente, F., Maitan, M.A., Bifulco, G., Andreozzi, F., Condorelli, G., Beguinot, F., In L6 skeletal muscle cells, glucose induces cytosolic translocation of protein kinase C-alpha and transactivates the insulin receptor kinase (1999) J. Biol. Chem., 274, pp. 28637-28644
Caruso, M., Maitan, M.A., Bifulco, G., Miele, C., Vigliotta, G., Oriente, F., Formisano, P., Beguinot, F., Activation and mitochondrial translocation of protein kinase Cδ are necessary for insulin stimulation of pyruvate dehydrogenase complex activity in muscle and liver cells (2001) J. Biol. Chem., 276, pp. 45088-45097
Casamayor, A., Morrice, N.A., Alessi, D.R., Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: Identification of five sites of phosphorylation in vivo (1999) Biochem. J., 342, pp. 287-292
Chou, M.M., Hou, W., Johnson, J., Graham, L.K., Lee, M.H., Chen, C.S., Newton, A.C., Toker, A., Regulation of protein kinase C zeta by PI 3-kinase and PDK-1 (1998) Curr. Biol., 8, pp. 1069-1077
Dong, L.Q., Liu, F., PDK2: The missing piece in the receptor tyrosine kinase signaling pathway puzzle (2005) Am. J. Physiol. Endocrinol. Metab., 289, pp. E187-E196
Dong, L.Q., Zhang, R., Langlais, P., He, H., Clark, M., Zhu, L., Liu, F., Primary structure, tissue distribution, and expression of mouse phosphoinositide-dependent protein kinase-1, a protein kinase that phosphorylates and activates protein kinase C (1999) J. Biol. Chem., 274, pp. 8117-8122
Dutil, E.M., Toker, A., Newton, A.C., Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1) (1998) Curr. Biol., 8, pp. 1366-1375
Fields, G.B., Noble, R.L., Solid phase peptide synthesis utilizing 9-fluorenylmethoxycarbonyl amino acids (1990) Int. J. Pept. Protein Res., 35, pp. 161-214
Filippa, N., Sable, C.L., Hemmings, B.A., Van Obberghen, E., Effect of phosphoinositide-dependent kinase 1 on protein kinase B translocation and its subsequent activation (2000) Mol. Cell. Biol., 20, pp. 5712-5721
Fiory, F., Oriente, F., Miele, C., Romano, C., Trencia, A., Alberobello, A.T., Esposito, I., Formisano, P., Protein kinase C-zeta and protein kinase B regulate distinct steps of insulin endocytosis and intracellular sorting (2004) J. Biol. Chem., 279, pp. 11137-11145
Formisano, P., Oriente, F., Miele, C., Caruso, M., Auricchio, R., Vigliotta, G., Condorelli, G., Beguinot, F., In NIH-3T3 fibroblasts, insulin receptor interaction with specific protein kinase C isoforms controls receptor intracellular routing (1998) J. Biol. Chem., 273, pp. 13197-13202
Formisano, P., Sohn, K.J., Miele, C., Di Finizio, B., Petruzziello, A., Riccardi, G., Beguinot, L., Beguinot, F., Mutation in a conserved motif next to the insulin receptor key autophosphorylation sites de-regulates kinase activity and impairs insulin action (1993) J. Biol. Chem., 268, pp. 5241-5248
Foukas, L.C., Shepherd, P.R., Phosphoinositide 3-kinase: The protein kinase that time forgot (2004) Biochem. Soc. Trans., 32, pp. 330-331
Grillo, S., Gremeaux, T., Casamayor, A., Alessi, D.R., Le Marchand-Brustel, Y., Tanti, J.F., Peroxovanadate induces tyrosine phosphorylation of phosphoinositide- dependent protein kinase-1 potential involvement of src kinase (2000) Eur. J. Biochem., 267, pp. 6642-6649
Hresko, R.C., Murata, H., Mueckler, M., Phosphoinositide-dependent kinase-2 is a distinct protein kinase enriched in a novel cytoskeletal fraction associated with adipocyte plasma membranes (2003) J. Biol. Chem., 278, pp. 21615-21622
Kandel, E.S., Hay, N., The regulation and activities of the multi-functional serine/threonine kinase Akt/PKB (1999) Exp. Cell Res., 253, pp. 210-229
Klippel, A., Reinhard, C., Kavanaugh, W.M., Apell, G., Escobedo, M.A., Williams, L.T., Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways (1996) Mol. Cell. Biol., 16, pp. 4117-4127
Kobayashi, T., Cohen, P., Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2 (1999) Biochem. J., 339, pp. 319-328
Levy-Toledano, R., Taouis, M., Blaettler, D.H., Gorden, P., Taylor, S.I., Insulin-induced activation of phosphatidyl inositol 3-kinase. Demonstration that the p85 subunit binds directly to the COOH terminus of the insulin receptor in intact cells (1994) J. Biol. Chem., 269, pp. 31178-31182
Maegawa, H., McClain, D.A., Freidenberg, G., Olefsky, J.M., Napier, M., Lipari, T., Dull, T.J., Ullrich, A., Properties of a human insulin receptor with a COOH-terminal truncation. II. Truncated receptors have normal kinase activity but are defective in signaling metabolic effects (1988) J. Biol. Chem., 263, pp. 8912-8917
McManus, E.J., Collins, B.J., Ashby, P.R., Prescott, A.R., Murray-Tait, V., Armit, L.J., Arthur, J.S., Alessi, D.R., The in vivo role of PtdIns(3,4,5)P(3) binding to PDK1 PH domain defined by knockin mutation (2004) EMBO J., 23, pp. 2071-2082
More, A., Komander, D., Van Aalten, D.M., Alessi, D.R., PDK1, the master regulator of AGC kinase signal transduction (2004) Semin. Cell Dev. Biol., 15, pp. 161-170
Myers, M.G., Backer, J.M., Siddle, K., White, M.F., The insulin receptor functions normally in Chinese hamster ovary cells after truncation of the C terminus (1991) J. Biol. Chem., 266, pp. 10616-10623
Park, J., Hill, M.M., Hess, D., Brazil, D.P., Hofsteenge, J., Hemmings, B.A., Identification of tyrosine phosphorylation sites on 3-phosphoinositide- dependent protein kinase-1 and their role in regulating kinase activity (2001) J. Biol. Chem., 276, pp. 37459-37471
Prasad, N., Topping, R.S., Zhou, D., Decker, S.J., Oxidative stress and vanadate induce tyrosine phosphorylation of phosphoinositide-dependent kinase 1 (PDK1) (2000) Biochemistry, 39, pp. 6929-6935
Piper, R.C., Hess, L.J., James, D.E., Differential sorting of two glucose transporters expressed in insulin-sensitive cells (1991) Am. J. Physiol., 260, pp. C570-C580
Romanelli, A., Dreisbach, V.C., Blenis, J., Characterization of phosphatidylinositol 3-kinase-dependent phosphorylation of the hydrophobic motif site Thr(389) in p70 S6 kinase 1 (2002) J. Biol. Chem., 277, pp. 40281-40289
Ruderman, N.B., Kapeller, R., White, M.F., Cantley, L.C., Activation of phosphatidylinositol 3-kinase by insulin (1990) Proc. Natl. Acad. Sci. USA, 87, pp. 1411-1415
Sakaue, H., Nishizawa, A., Ogawa, W., Teshigawara, K., Mori, T., Takashima, Y., Noda, T., Kasuga, M., Requirement for 3-phosphoinositide-dependent kinase-1 (PDK-1) in insulin-induced glucose uptake in immortalized brown adipocytes (2003) J. Biol. Chem., 278, pp. 38870-38874
Sarbassov, D.D., Guertin, D.A., Ali, S.M., Sabatini, D.M., Phosphorylation and regulation of Akt/PKB by the Rictor-mTOR complex (2005) Science, 307, pp. 1098-1101
Simpson, I.A., Yver, D.R., Hissin, P.J., Wardzala, L.J., Karnieli, E., Salans, L.B., Cushman, S.W., Insulin-stimulated translocation of glucose transporters in the isolated rat adipose cells: Characterization of subcellular fractions (1983) Biochim. Biophys. Acta, 763, pp. 393-407
Storz, P., Toker, A., 3′-Phosphoinositide-dependent kinase-1 (PDK-1) in PI 3-kinase signaling (2002) Front Biosci., 7, pp. 886-902
Vanhaesebroeck, B., Alessi, D.R., The PI3K-PDK1 connection: More than just a road to PKB (2000) Biochem. J., 346, pp. 561-576
Van Horn, D.J., Myers Jr., M.G., Backer, J.M., Direct activation of the phosphatidylinositol 3′-kinase by the insulin receptor (1994) J. Biol. Chem., 269, pp. 29-32
Vigliotta, G., Miele, C., Santopietro, S., Portella, G., Perfetti, A., Maitan, M.A., Cassese, A., Beguinot, F., Overexpression of the ped/pea-15 gene causes diabetes by impairing glucose-stimulated insulin secretion in addition to insulin action (2004) Mol. Cell. Biol., 24, pp. 5005-5015
Wei, Q., Xia, Y., Roles of 3-phosphoinositide-dependent kinase 1 in the regulation of endothelial nitric-oxide synthase phosphorylation and function by heat shock protein 90 (2005) J. Biol. Chem., 280, pp. 18081-18086
Wick, K.L., Liu, F., A new molecular target of insulin action: Regulating the pivotal PDK1 (2001) Curr. Drug Targets Immune Endocr. Metabol. Disord., 1, pp. 209-221
Williams, M.R., Arthur, J.S., Balendran, A., Van Der Kaay, J., Poli, V., Cohen, P., Alessi, D.R., The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells (2000) Curr. Biol., 10, pp. 439-448
Alessi, D. R., Kozlowski, M. T., Weng, Q. P., Morrice, N., Avruch, J., 3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro (1998) Curr. Biol., 8, pp. 69-8
Anderson, K. E., Coadwell, J., Stephens, L. R., Hawkins, P. T., Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B (1998) Curr. Biol., 8, pp. 684-691
Cantrell, D. A., Phosphoinositide 3-kinase signalling pathways (2001) J. Cell Sci., 114, pp. 1439-1445
Chou, M. M., Hou, W., Johnson, J., Graham, L. K., Lee, M. H., Chen, C. S., Newton, A. C., Toker, A., Regulation of protein kinase C zeta by PI 3-kinase and PDK-1 (1998) Curr. Biol., 8, pp. 1069-1077
Dong, L. Q., Liu, F., PDK2: The missing piece in the receptor tyrosine kinase signaling pathway puzzle (2005) Am. J. Physiol. Endocrinol. Metab., 289, pp. E187-E196
Dong, L. Q., Zhang, R., Langlais, P., He, H., Clark, M., Zhu, L., Liu, F., Primary structure, tissue distribution, and expression of mouse phosphoinositide-dependent protein kinase-1, a protein kinase that phosphorylates and activates protein kinase C (1999) J. Biol. Chem., 274, pp. 8117-8122
Dutil, E. M., Toker, A., Newton, A. C., Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1) (1998) Curr. Biol., 8, pp. 1366-1375
Fields, G. B., Noble, R. L., Solid phase peptide synthesis utilizing 9-fluorenylmethoxycarbonyl amino acids (1990) Int. J. Pept. Protein Res., 35, pp. 161-214
Foukas, L. C., Shepherd, P. R., Phosphoinositide 3-kinase: The protein kinase that time forgot (2004) Biochem. Soc. Trans., 32, pp. 330-331
Hresko, R. C., Murata, H., Mueckler, M., Phosphoinositide-dependent kinase-2 is a distinct protein kinase enriched in a novel cytoskeletal fraction associated with adipocyte plasma membranes (2003) J. Biol. Chem., 278, pp. 21615-21622
Kandel, E. S., Hay, N., The regulation and activities of the multi-functional serine/threonine kinase Akt/PKB (1999) Exp. Cell Res., 253, pp. 210-229
McManus, E. J., Collins, B. J., Ashby, P. R., Prescott, A. R., Murray-Tait, V., Armit, L. J., Arthur, J. S., Alessi, D. R., The in vivo role of PtdIns (3, 4, 5) P (3) binding to PDK1 PH domain defined by knockin mutation (2004) EMBO J., 23, pp. 2071-2082
Myers, M. G., Backer, J. M., Siddle, K., White, M. F., The insulin receptor functions normally in Chinese hamster ovary cells after truncation of the C terminus (1991) J. Biol. Chem., 266, pp. 10616-10623
Park, J., Hill, M. M., Hess, D., Brazil, D. P., Hofsteenge, J., Hemmings, B. A., Identification of tyrosine phosphorylation sites on 3-phosphoinositide- dependent protein kinase-1 and their role in regulating kinase activity (2001) J. Biol. Chem., 276, pp. 37459-37471
Piper, R. C., Hess, L. J., James, D. E., Differential sorting of two glucose transporters expressed in insulin-sensitive cells (1991) Am. J. Physiol., 260, pp. C570-C580
Ruderman, N. B., Kapeller, R., White, M. F., Cantley, L. C., Activation of phosphatidylinositol 3-kinase by insulin (1990) Proc. Natl. Acad. Sci. USA, 87, pp. 1411-1415
Sarbassov, D. D., Guertin, D. A., Ali, S. M., Sabatini, D. M., Phosphorylation and regulation of Akt/PKB by the Rictor-mTOR complex (2005) Science, 307, pp. 1098-1101
Simpson, I. A., Yver, D. R., Hissin, P. J., Wardzala, L. J., Karnieli, E., Salans, L. B., Cushman, S. W., Insulin-stimulated translocation of glucose transporters in the isolated rat adipose cells: Characterization of subcellular fractions (1983) Biochim. Biophys. Acta, 763, pp. 393-407
Van Horn, D. J., Myers Jr., M. G., Backer, J. M., Direct activation of the phosphatidylinositol 3 -kinase by the insulin receptor (1994) J. Biol. Chem., 269, pp. 29-32
Wick, K. L., Liu, F., A new molecular target of insulin action: Regulating the pivotal PDK1 (2001) Curr. Drug Targets Immune Endocr. Metabol. Disord., 1, pp. 209-221
Williams, M. R., Arthur, J. S., Balendran, A., Van Der Kaay, J., Poli, V., Cohen, P., Alessi, D. R., The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells (2000) Curr. Biol., 10, pp. 439-448
Mol Cell Biol (ISSN: 0270-7306, 1098-5549), 2005 Dec; 25(24): 10803-10814.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article,
Impact factor: 7.093, 5-year impact factor Impact factor a 5 anni: 5.614
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-28544448231&partnerID=40&md5=1539c0b5e4b18c6076457b1823bea233
Keywords Parole chiave: Glucose, Insulin, Insulin Receptor, Phenylalanine, Phosphatidylinositide, Phosphatidylinositol 3 Kinase, Phosphoinositide Dependent Kinase 1, Protein Kinase B, Protein Tyrosine Kinase, Threonine, Unclassified Drug, Amino Acid Substitution, Animal Cell, Article, Carboxy Terminal Sequence, Controlled Study, Enzyme Activation, Gene Deletion, Glucose Metabolism, Glucose Transport, In Vitro Study, Insulin Metabolism, Myoblast, Nonhuman, Priority Journal, Protein Expression, Protein Phosphorylation, Signal Transduction, Cultured, Intracellular Signaling Peptides And Proteins, Phosphoproteins, Protein-Serine-Threonine Kinases, Sequence Deletion,
Affiliations Affiliazioni:
*** IBB - CNR ***
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Università degli Studi di Napoli Federico II, Naples, Italy
Istituto di Biostrutture e Bioimmagini del CNR, Naples, Italy
Department of Clinical Biochemistry, Glostrup Hospital, DK 2600 Glostrup, Denmark
Mammalian Cell Technology, Novo Nordisk A/S, DK 2880 Bagsvaerd, Denmark
References Riferimenti:
Alessi, D.R., Kozlowski, M.T., Weng, Q.P., Morrice, N., Avruch, J., 3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro (1998) Curr. Biol., 8, pp. 69-8
Anderson, K.E., Coadwell, J., Stephens, L.R., Hawkins, P.T., Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B (1998) Curr. Biol., 8, pp. 684-691
Belham, C., Wu, S., Avruch, J., Intracellular signalling: PDK-1-a kinase at the hub of things (1999) Curr. Biol., 9, pp. R93-R96
Cantrell, D.A., Phosphoinositide 3-kinase signalling pathways (2001) J. Cell Sci., 114, pp. 1439-1445
Caruso, M., Miele, C., Oriente, F., Maitan, M.A., Bifulco, G., Andreozzi, F., Condorelli, G., Beguinot, F., In L6 skeletal muscle cells, glucose induces cytosolic translocation of protein kinase C-alpha and transactivates the insulin receptor kinase (1999) J. Biol. Chem., 274, pp. 28637-28644
Caruso, M., Maitan, M.A., Bifulco, G., Miele, C., Vigliotta, G., Oriente, F., Formisano, P., Beguinot, F., Activation and mitochondrial translocation of protein kinase Cδ are necessary for insulin stimulation of pyruvate dehydrogenase complex activity in muscle and liver cells (2001) J. Biol. Chem., 276, pp. 45088-45097
Casamayor, A., Morrice, N.A., Alessi, D.R., Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: Identification of five sites of phosphorylation in vivo (1999) Biochem. J., 342, pp. 287-292
Chou, M.M., Hou, W., Johnson, J., Graham, L.K., Lee, M.H., Chen, C.S., Newton, A.C., Toker, A., Regulation of protein kinase C zeta by PI 3-kinase and PDK-1 (1998) Curr. Biol., 8, pp. 1069-1077
Dong, L.Q., Liu, F., PDK2: The missing piece in the receptor tyrosine kinase signaling pathway puzzle (2005) Am. J. Physiol. Endocrinol. Metab., 289, pp. E187-E196
Dong, L.Q., Zhang, R., Langlais, P., He, H., Clark, M., Zhu, L., Liu, F., Primary structure, tissue distribution, and expression of mouse phosphoinositide-dependent protein kinase-1, a protein kinase that phosphorylates and activates protein kinase C (1999) J. Biol. Chem., 274, pp. 8117-8122
Dutil, E.M., Toker, A., Newton, A.C., Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1) (1998) Curr. Biol., 8, pp. 1366-1375
Fields, G.B., Noble, R.L., Solid phase peptide synthesis utilizing 9-fluorenylmethoxycarbonyl amino acids (1990) Int. J. Pept. Protein Res., 35, pp. 161-214
Filippa, N., Sable, C.L., Hemmings, B.A., Van Obberghen, E., Effect of phosphoinositide-dependent kinase 1 on protein kinase B translocation and its subsequent activation (2000) Mol. Cell. Biol., 20, pp. 5712-5721
Fiory, F., Oriente, F., Miele, C., Romano, C., Trencia, A., Alberobello, A.T., Esposito, I., Formisano, P., Protein kinase C-zeta and protein kinase B regulate distinct steps of insulin endocytosis and intracellular sorting (2004) J. Biol. Chem., 279, pp. 11137-11145
Formisano, P., Oriente, F., Miele, C., Caruso, M., Auricchio, R., Vigliotta, G., Condorelli, G., Beguinot, F., In NIH-3T3 fibroblasts, insulin receptor interaction with specific protein kinase C isoforms controls receptor intracellular routing (1998) J. Biol. Chem., 273, pp. 13197-13202
Formisano, P., Sohn, K.J., Miele, C., Di Finizio, B., Petruzziello, A., Riccardi, G., Beguinot, L., Beguinot, F., Mutation in a conserved motif next to the insulin receptor key autophosphorylation sites de-regulates kinase activity and impairs insulin action (1993) J. Biol. Chem., 268, pp. 5241-5248
Foukas, L.C., Shepherd, P.R., Phosphoinositide 3-kinase: The protein kinase that time forgot (2004) Biochem. Soc. Trans., 32, pp. 330-331
Grillo, S., Gremeaux, T., Casamayor, A., Alessi, D.R., Le Marchand-Brustel, Y., Tanti, J.F., Peroxovanadate induces tyrosine phosphorylation of phosphoinositide- dependent protein kinase-1 potential involvement of src kinase (2000) Eur. J. Biochem., 267, pp. 6642-6649
Hresko, R.C., Murata, H., Mueckler, M., Phosphoinositide-dependent kinase-2 is a distinct protein kinase enriched in a novel cytoskeletal fraction associated with adipocyte plasma membranes (2003) J. Biol. Chem., 278, pp. 21615-21622
Kandel, E.S., Hay, N., The regulation and activities of the multi-functional serine/threonine kinase Akt/PKB (1999) Exp. Cell Res., 253, pp. 210-229
Klippel, A., Reinhard, C., Kavanaugh, W.M., Apell, G., Escobedo, M.A., Williams, L.T., Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways (1996) Mol. Cell. Biol., 16, pp. 4117-4127
Kobayashi, T., Cohen, P., Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2 (1999) Biochem. J., 339, pp. 319-328
Levy-Toledano, R., Taouis, M., Blaettler, D.H., Gorden, P., Taylor, S.I., Insulin-induced activation of phosphatidyl inositol 3-kinase. Demonstration that the p85 subunit binds directly to the COOH terminus of the insulin receptor in intact cells (1994) J. Biol. Chem., 269, pp. 31178-31182
Maegawa, H., McClain, D.A., Freidenberg, G., Olefsky, J.M., Napier, M., Lipari, T., Dull, T.J., Ullrich, A., Properties of a human insulin receptor with a COOH-terminal truncation. II. Truncated receptors have normal kinase activity but are defective in signaling metabolic effects (1988) J. Biol. Chem., 263, pp. 8912-8917
McManus, E.J., Collins, B.J., Ashby, P.R., Prescott, A.R., Murray-Tait, V., Armit, L.J., Arthur, J.S., Alessi, D.R., The in vivo role of PtdIns(3,4,5)P(3) binding to PDK1 PH domain defined by knockin mutation (2004) EMBO J., 23, pp. 2071-2082
More, A., Komander, D., Van Aalten, D.M., Alessi, D.R., PDK1, the master regulator of AGC kinase signal transduction (2004) Semin. Cell Dev. Biol., 15, pp. 161-170
Myers, M.G., Backer, J.M., Siddle, K., White, M.F., The insulin receptor functions normally in Chinese hamster ovary cells after truncation of the C terminus (1991) J. Biol. Chem., 266, pp. 10616-10623
Park, J., Hill, M.M., Hess, D., Brazil, D.P., Hofsteenge, J., Hemmings, B.A., Identification of tyrosine phosphorylation sites on 3-phosphoinositide- dependent protein kinase-1 and their role in regulating kinase activity (2001) J. Biol. Chem., 276, pp. 37459-37471
Prasad, N., Topping, R.S., Zhou, D., Decker, S.J., Oxidative stress and vanadate induce tyrosine phosphorylation of phosphoinositide-dependent kinase 1 (PDK1) (2000) Biochemistry, 39, pp. 6929-6935
Piper, R.C., Hess, L.J., James, D.E., Differential sorting of two glucose transporters expressed in insulin-sensitive cells (1991) Am. J. Physiol., 260, pp. C570-C580
Romanelli, A., Dreisbach, V.C., Blenis, J., Characterization of phosphatidylinositol 3-kinase-dependent phosphorylation of the hydrophobic motif site Thr(389) in p70 S6 kinase 1 (2002) J. Biol. Chem., 277, pp. 40281-40289
Ruderman, N.B., Kapeller, R., White, M.F., Cantley, L.C., Activation of phosphatidylinositol 3-kinase by insulin (1990) Proc. Natl. Acad. Sci. USA, 87, pp. 1411-1415
Sakaue, H., Nishizawa, A., Ogawa, W., Teshigawara, K., Mori, T., Takashima, Y., Noda, T., Kasuga, M., Requirement for 3-phosphoinositide-dependent kinase-1 (PDK-1) in insulin-induced glucose uptake in immortalized brown adipocytes (2003) J. Biol. Chem., 278, pp. 38870-38874
Sarbassov, D.D., Guertin, D.A., Ali, S.M., Sabatini, D.M., Phosphorylation and regulation of Akt/PKB by the Rictor-mTOR complex (2005) Science, 307, pp. 1098-1101
Simpson, I.A., Yver, D.R., Hissin, P.J., Wardzala, L.J., Karnieli, E., Salans, L.B., Cushman, S.W., Insulin-stimulated translocation of glucose transporters in the isolated rat adipose cells: Characterization of subcellular fractions (1983) Biochim. Biophys. Acta, 763, pp. 393-407
Storz, P., Toker, A., 3′-Phosphoinositide-dependent kinase-1 (PDK-1) in PI 3-kinase signaling (2002) Front Biosci., 7, pp. 886-902
Vanhaesebroeck, B., Alessi, D.R., The PI3K-PDK1 connection: More than just a road to PKB (2000) Biochem. J., 346, pp. 561-576
Van Horn, D.J., Myers Jr., M.G., Backer, J.M., Direct activation of the phosphatidylinositol 3′-kinase by the insulin receptor (1994) J. Biol. Chem., 269, pp. 29-32
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Tyrosine phosphorylation of phosphoinositide-dependent kinase 1 by the insulin receptor is necessary for insulin metabolic signaling
In L6 myoblasts, insulin receptors with deletion of the C-terminal 43 amino acids (IR Δ43) exhibited normal autophosphorylation and IRS-1/2 tyrosine phosphorylation. The L6 cells expressing IR Δ43 (L6 IRΔ43) also showed no inselin effect on glucose uptake and glycogen synthase, accompanied by a >80% decrease in insulin induction of 3-phosphoinositide-dependent protein kinase 1 (PDK-1) activity and tyrosine phosphorylation and of protein kinase B (PKB) phosphorylation at Thr 308. Insulin induced the phosphatidylinositol 3 kinase-dependent coprecipitation of PDK-1 with wild-type IR (IR WT), but not IR Δ43. Based on overlay blotting, PDK-1 directly bound IR WT, but not IR Δ43. Insulin-activated IR WT, and not IR Δ43, phosphorylated PDK-1 at tyrosines 9, 373, and 376. The IR C-terminal 43-amino-acid peptide (C-terminal peptide) inhibited in vitro PDK-1 tyrosine phosphorylation by the IR. Tyr→Phe substitution prevented this inhibitory action. In the L6 hIR cells, the C-terminal peptide coprecipitated with PDK-1 in an insulin-stimulated fashion. This peptide simultaneously impaired the insulin effect on PDK-1 coprecipitation with IR WT, on PDK-1 tyrosine phosphorylation, on PKB phosphorylation at Thr 308, and on glucose uptake. Upon insulin exposure, PDK-1 membrane persistence was significantly reduced in L6 IRΔ43 compared to control cells. In L6 cells expressing IR WT, the C-terminal peptide also impaired insulin-dependent PDK-1 membrane persistence. Thus, PDK-1 directly binds to the insulin receptor, followed by PDK-1 activation and insulin metabolic effects. Copyright © 2005, American Society for Microbiology. All Rights Reserved.
In L6 myoblasts, insulin receptors with deletion of the C-terminal 43 amino acids (IR Δ43) exhibited normal autophosphorylation and IRS-1/2 tyrosine phosphorylation. The L6 cells expressing IR Δ43 (L6 IRΔ43) also showed no inselin effect on glucose uptake and glycogen synthase, accompanied by a >80% decrease in insulin induction of 3-phosphoinositide-dependent protein kinase 1 (PDK-1) activity and tyrosine phosphorylation and of protein kinase B (PKB) phosphorylation at Thr 308. Insulin induced the phosphatidylinositol 3 kinase-dependent coprecipitation of PDK-1 with wild-type IR (IR WT), but not IR Δ43. Based on overlay blotting, PDK-1 directly bound IR WT, but not IR Δ43. Insulin-activated IR WT, and not IR Δ43, phosphorylated PDK-1 at tyrosines 9, 373, and 376. The IR C-terminal 43-amino-acid peptide (C-terminal peptide) inhibited in vitro PDK-1 tyrosine phosphorylation by the IR. Tyr→Phe substitution prevented this inhibitory action. In the L6 hIR cells, the C-terminal peptide coprecipitated with PDK-1 in an insulin-stimulated fashion. This peptide simultaneously impaired the insulin effect on PDK-1 coprecipitation with IR WT, on PDK-1 tyrosine phosphorylation, on PKB phosphorylation at Thr 308, and on glucose uptake. Upon insulin exposure, PDK-1 membrane persistence was significantly reduced in L6 IRΔ43 compared to control cells. In L6 cells expressing IR WT, the C-terminal peptide also impaired insulin-dependent PDK-1 membrane persistence. Thus, PDK-1 directly binds to the insulin receptor, followed by PDK-1 activation and insulin metabolic effects. Copyright © 2005, American Society for Microbiology. All Rights Reserved.
Tyrosine phosphorylation of phosphoinositide-dependent kinase 1 by the insulin receptor is necessary for insulin metabolic signaling
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Tyrosine phosphorylation of phosphoinositide-dependent kinase 1 by the insulin receptor is necessary for insulin metabolic signaling
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Alterio V, Vitale RM, Monti SM, Pedone C, Scozzafava A, Cecchi A, De Simone G, Supuran CT
* Carbonic anhydrase inhibitors: X-ray and molecular modeling study for the interaction of a fluorescent antitumor sulfonamide with isozyme II and IX (384 visite)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2006 Jun 28; 128(25): 8329-8335.
Impact Factor: 7.696
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De Capua A, Goodman M, Amino Y, Saviano M, Benedetti E
* Conformation analysis of aspartame-based sweeteners by NMR spectroscopy, molecular dynamics simulations, and X-ray diffraction studies (595 visite)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2006 Feb; 7(2): 377-387.
Impact Factor: 4.1
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Menchise V, De Simone G, Alterio V, Di Fiore A, Pedone C, Scozzafava A, Supuran CT
* Carbonic anhydrase inhibitors: Stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II (450 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2005 Sep 8; 48(18): 5721-5727.
Impact Factor: 4.926
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La Mendola D, Bonomo RP, Impellizzeri G, Maccarrone G, Pappalardo G, Pietropaolo A, Rizzarelli E, Zito V
* Copper(II) complexes with chicken prion repeats: Influence of proline and tyrosine residues on the coordination features (282 visite)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2005 Sep; 10(5): 463-475.
Impact Factor: 3.224
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Foti D, Chiefari E, Fedele M, Iuliano R, Brunetti L, Paonessa F, Manfioletti G, Barbetti F, Brunetti A, Croce CM, Fusco A, Brunetti A
* Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice (365 visite)
Nat Med (ISSN: 1078-8956, 0034-7264), 2005 Jul; 11(7): 765-773.
Impact Factor: 28.878
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La Rosa C, Milardi D, Amato E, Pappalardo M, Grasso D
* Molecular mechanism of the inhibition of cytochrome c aggregation by Phe-Gly (463 visite)
Arch Biochem Biophys (ISSN: 0003-9861), 2005 Mar 1; 435(1): 182-189.
Impact Factor: 3.152
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Iaccarino G, Ciccarelli M, Sorriento D, Galasso G, Campanile A, Santulli G, Cipolletta E, Cerullo V, Cimini V, Altobelli GG, Piscione F, Priante O, Pastore L, Chiariello M, Salvatore F, Koch WJ, Trimarco B
* Ischemic neoangiogenesis enhanced by β2-adrenergic receptor overexpression: A novel role for the endothelial adrenergic system (326 visite)
Circ Res (ISSN: 0009-7330, 1524-4571electronic), 2005; 97(11): 1182-1189.
Impact Factor: 9.408
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Saviano M, Improta R, Benedetti E, Carrozzini B, Cascarano GL, Didierjean C, Toniolo C, Crisma M
* Benzophenone photophore flexibility and proximity: Molecular and crystal-state structure of a Bpa-containing trichogin dodecapeptide analogue (365 visite)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2004 Apr 2; 5(4): 541-544.
Impact Factor: 3.474
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Cucinotta V, Giuffrida A, La Mendola D, Maccarrone G, Puglisi A, Rizzarelli E, Vecchio G
* 3-Amino Derivative Of Beta-Cyclodextrin: Thermodynamics Of Copper (ii) Complexes And Exploitation Of Its Enantioselectivity In The Separation Of Amino Acid Racemates By Ligand Exchange Capillary Electrophoresis (332 visite)
And Life Sciencesjournal Of Chromatography B Analytical Technologies In The Biomedical, 2004 Feb 5; 800(1-2): 127-133.
Impact Factor: 1.403
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Mansi R, Tesauro D, De Capua A, Fattorusso R, Carac C, Aloj L, Benedetti E, Morelli G
* Peptide-chelating agent conjugate for selective targeting of somatostatin receptor type 1: Synthesis and characterization (425 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 527-534.
Impact Factor: 2.863
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Palladino P, Pedone C, Ragone R, Rossi F, Saviano M, Benedetti E
* A simplified model of the binding interaction between stromal cell-derived factor-1 chemokine and CXC chemokine receptor (318 visite)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2003 Apr; 10(2): 133-138.
Impact Factor: 0.46
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Palladino P, De Capua A, Pedone C, Ragone R, Rossi F, Limatola C, Ragozzino D, Benedetti E
* A simplified model of the interaction between SDF-1 chemokine and the CXCR4 receptor (362 visite)
Peptide Revolution, 2003 Apr; 10(2): 133-138.
Impact Factor: 4.659
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Meyer Lindenberg A, Miletich RS, Kohn PD, Esposito G, Carson RE, Quarantelli M, Weinberger DR, Berman KF
* Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia (470 visite)
Nat Neurosci (ISSN: 1097-6256), 2002 Mar; 5(3): 267-271.
Impact Factor: 14.857
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Lauceri R, Raudino A, Scolaro LM, Micali N, Purrello R
* From achiral porphyrins to template-imprinted chiral aggregates and further. Self-replication of chiral memory from scratch (466 visite)
J Am Chem Soc (ISSN: 0002-7863print, 0002-7863linking, 1520-5126electronic), 2002 Feb 13; 120(47): 894-895.
Impact Factor: 9.023
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Maccarrone G, Nardin G, Randaccio L, Tabbì G, Rosi M, Sgamellotti A, Rizzarelli E, Zangrando E
Structure Of Copper(ii) Complexes With L-Leucyl-D-Phenylalanine Or L-Leucyl-L-Phenylalanine And Lcao-Scf-Mo Calculations On The Stabilization Of Copper(ii) Complexes Due To D-π Interaction With Aromatic Ring (337 visite)
Dalton Trans, 1996; N/D: 3449-3453.
Impact Factor: 0
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Bonomo RP, De Flora A, Rizzarelli E, Santoro AM, Tabbì G, Tonetti M
Copper(II) complexes encapsulated in human red blood cells (558 visite)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1995 Sep; 59(4): 773-784.
Impact Factor: 1.342
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FRITTITTA L, VIGNERI R, PAPA V, GOLDFINE I, GRASSO G, TRISCHITTA V
Structural and functional studies of insulin receptors in human breast cancer (401 visite)
Breast Cancer Res Tr Kluwer Academic Publishers (ISSN: 0167-6806), 1993; 25(1): 73-82.
Impact Factor: 2.43
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Papa V, Reese CC, Brunetti A, Vigneri R, Siiteri PK, Goldfine ID
Progestins increase insulin receptor content and insulin stimulation of growth in human breast carcinoma cells (416 visite)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1990 Dec 15; 50(24): 7858-7862.
Impact Factor: 8.426
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Trischitta V, Brunetti A, Chiavetta A, Benzi L, Papa V, Vigneri R
Defects in insulin-receptor internalization and processing in monocytes of obese subjects and obese NIDDM patients (285 visite)
Diabetesdiabetes (ISSN: 0012-1797), 1989 Dec; 38(12): 1579-1584.
Impact Factor: 8.675
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Pezzino V, Papa V, Trischitta V, Brunetti A, Goodman PA, Treutelaar MK, Williams JA, Maddux BA, Vigneri R, Goldfine ID
Human insulin receptor radioimmunoassay: Applicability to insulin-resistant states (237 visite)
Am J Physiol Endocrinol Metab (ISSN: 0002-9513), 1989 Sep; 257(3): N/D-N/D.
Impact Factor: 3.116
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Trischitta V, Wong KY, Brunetti A, Scalisi R, Vigneri R, Goldfine ID
Endocytosis, recycling, and degradation of the insulin receptor. Studies with monoclonal antireceptor antibodies that do not activate receptor kinase (304 visite)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 1989 Mar 25; 264(9): 5041-5046.
Impact Factor: 6.963
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Marletta F, Rizzarelli E, Mangiameli A, Brogna A, Sammartano S, Monaco S, Blasi A
Effects of graded doses of copper complexes of L-aminoacids on gastric acid secretion in rats (1273 visite)
Boll Soc Ital Biol Sper (ISSN: 0037-8771), 1979 Apr 30; 55(8): 769-775.
Impact Factor: 0
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63 Records (60 escludendo Abstract e Conferenze).
Impact factor totale: 315.066 (302.231 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 330.776 (324.732 escludendo Abstract e Conferenze).
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Diaferia C, Avitabile C, Leone M, Gallo E, Saviano M, Accardo A, Romanelli A
* Diphenylalanine Motif Drives Self-Assembling in Hybrid PNA-Peptide Conjugates (2 visite)
Chemistry (ISSN: 0947-6539linking), 2021 Jul 27; N/D: N/D-N/D.
Impact Factor: 5.236
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Fik-jaskółkaa MA, Mkrtchyand AF, Saghyand AS, Palumbo R, Belter A, Hayriyand LA, Simonyane H, Roviello V, Roviello GN
* Biological macromolecule binding and anticancer activity of synthetic alkyne-containing L-phenylalanine derivatives (128 visite)
Amino Acids (ISSN: 0939-4451linking), 2020 May; 52(5): 755-769.
Impact Factor: 3.063
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Avitabile C, Diaferia C, Roviello V, Altamura D, Giannini C, Vitagliano L, Accardo A, Romanelli A
* Fluorescence and Morphology of Self-Assembled Nucleobases and Their Diphenylalanine Hybrid Aggregates (153 visite)
Chemistry (ISSN: 0947-6539linking), 2019 Nov 22; 25(65): 14850-14857.
Impact Factor: 5.476
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Diaferia C, Balasco N, Altamura D, Sibillano T, Gallo E, Roviello V, Giannini C, Morelli G, Vitagliano L, Accardo A
* Assembly modes of hexaphenylalanine variants as function of the charge states of their terminal ends (35 visite)
Soft Matter (ISSN: 1744-683xlinking), 2018 Oct 17; 14 (40 ): 8219-8230.
Impact Factor:
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Roviello GN
* Novel insights into nucleoamino acids: biomolecular recognition and aggregation studies of a thymine-conjugated L-phenyl alanine (359 visite)
Amino Acids (ISSN: 1438-2199electronic, 0939-4451linking), 2018 May 15; DOI10.1007/s00726-01: 933-941.
Impact Factor: 3.173
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Diaferia C, Sibillano T, Altamura D, Roviello V, Vitagliano L, Giannini C, Morelli G, Accardo A
* Structural Characterization of PEGylated Hexaphenylalanine Nanostructures Exhibiting Green Photoluminescence Emission (870 visite) (PDF 217 visite)
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Impact Factor: 5.16
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Accardo A, Morelli G, Diaferia C, Vitagliano L, Giannini C, Sibillano T, Roviello V
* Photoluminescent peptide based nanostructures as FRET donor for fluorophore dye (351 visite)
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Impact Factor: 5.16
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Troise AD, Buonanno M, Fiore A, Monti SM, Fogliano V
* Evolution of protein bound Maillard reaction end-products and free Amadori compounds in low lactose milk in presence of fructosamine oxidase (304 visite)
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Impact Factor: 4.529
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Vigneri R, Goldfine ID, Frittitta L
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J Endocrinol Invest (ISSN: 1720-8386, 0391-4097, 1720-8386electronic), 2016 Dec; 39(12): 1365-1376.
Impact Factor: 2.633
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Diaferia C, Sibillano T, Balasco N, Giannini C, Roviello V, Vitagliano L, Morelli G, Accardo A
* Hierarchical Analysis of Self-Assembled PEGylated Hexaphenylalanine Photoluminescent Nanostructures (365 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2016 Nov 7; 22(46): 16586-16597.
Impact Factor: 5.317
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Diaferia C, Mercurio FA, Giannini C, Sibillano T, Morelli G, Leone M, Accardo A
* Self-assembly of PEGylated tetra-phenylalanine derivatives: structural insights from solution and solid state studies (257 visite)
Sci Rep (ISSN: 2045-2322, 2045-2322electronic, 2045-2322linking), 2016 May 25; 6: 26638-26638.
Impact Factor: 4.259
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Troise AD, Fiore A, Roviello GN, Monti SM, Fogliano V
* Simultaneous quantification of amino acids and Amadori products in foods through ion-pairing liquid chromatography-high-resolution mass spectrometry (808 visite)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2015 Jan; 47(1): 111-124.
Impact Factor: 3.196
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Braccini L, Ciraolo E, Campa CC, Perino A, Longo DL, Tibolla G, Pregnolato M, Cao Y, Tassone B, Damilano F, Laffargue M, Calautti E, Falasca M, Norata GD, Backer JM, Hirsch E
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Perri F, Pacelli R, Della Vittoria Scarpati G, Cella L, Giuliano M, Caponigro F, Pepe S
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Impact Factor: 2.385
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DeRosa A, Carducci C, Carducci C, Peluso S, Lieto M, Mazzella A, Saccà F, Brescia Morra V, Pappata S, Leuzzi V, De Michele G
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Impact Factor: 3.377
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Milardi D, Sciacca MF, Randazzo L, Raudino A, La Rosa C
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Impact Factor: 19.358
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Chembiochem (ISSN: 1439-4227, 1439-9422, 1439-7633), 2013 Jan 2; 14(1): 100-106.
Impact Factor: 2.92
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Tedesco I, Russo M, Bilotto S, Spagnuolo C, Scognamiglio A, Palumbo R, Nappo A, Iacomino G, Moio L, Russo GL
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Food Chem Toxicol (ISSN: 0278-6915), 2013; 60: 377-384.
Impact Factor: 2.61
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Kaprelyants AS, Mukamolova GV, Ruggiero A, Makarov VA, Demina GR, Shleeva MO, Potapov VD, Shramko PA
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Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2012 Oct; 19(10): 1026-1034.
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J Struct Biol (ISSN: 1047-8477), 2012 Feb; 177(2): 506-512.
Impact Factor: 3.361
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Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2012; 3(12): N/D-N/D.
Impact Factor: 6.044
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Cucinotta V, Giuffrida A, Grasso G, MacCarrone G, Mazzaglia A, Messina M, Vecchio G
* Diaminotrehalose-capped β-cyclodextrin, a new member of hemispherodextrins: Synthesis, thermodynamic and spectroscopic characterization and its exploitation in chiral electrokinetic chromatography (355 visite)
J Sep Sci (ISSN: 1615-9306), 2011 Jan; 34(1): 70-76.
Impact Factor: 2.733
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Milardi D, Sciacca MFM, Pappalardo M, Grasso DM, La Rosa C
* The Role Of Aromatic Side-Chains In Amyloid Growth And Membrane Interaction Of The Islet Amyloid Polypeptide Fragment Lanflvh (403 visite)
Eur Biophys J, 2011 Jan; 40(1): 1-12.
Impact Factor: 3.832
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Di Fiore A, Monti SM, Innocenti A, Winum J-Y, De Simone G, Supuran CT
* Carbonic anhydrase inhibitors: Crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV (320 visite)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2010 Jun 15; 20(12): 3601-3605.
Impact Factor: 2.661
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Giuffrida ML, Caraci F, Pignataro B, Cataldo S, De Bona P, Bruno V, Molinaro G, Pappalardo G, Messina A, Palmigiano A, Garozzo D, Nicoletti F, Rizzarelli E, Copani A
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J Neurosci (ISSN: 1529-2401, 0270-6474), 2009 Sep 26; 29(34): 10582-10587.
Impact Factor: 3.669
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Carriero MV, Longanesi-cattani I, Bifulco K, Maglio O, Lista L, Barbieri A, Votta G, Masucci MT, Arra C, Franco R, De Rosa M, Stoppelli MP, Pavone V
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Impact Factor: 4.953
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Illario M, Monaco S, Cavallo AL, Esposito I, Formisano P, D'Andrea LD, Cipolletta E, Trimarco B, Fenzi G, Rossi G, Vitale M
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Cell Signal (ISSN: 0898-6568), 2009 May; 21(5): 786-792.
Impact Factor: 4.094
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Daniele A, Scala I, Cardillo G, Pennino C, Ungaro C, Sibilio M, Parenti G, Esposito L, Zagari A, Andria G, Salvatore F
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Febs Journal (ISSN: 1742-464x), 2009 Apr; 276(7): 2048-2059.
Impact Factor: 3.042
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J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 166-174.
Impact Factor: 1.807
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Lauceri R, Fasciglione G, D'Urso A, Marini S, Purrello R, Coletta M
* Kinetic investigation of porphyrin interaction with chiral templates reveals unexpected features of the induction and self-propagation mechanism of chiral memory (388 visite)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2008 Sep 13; 130(32): 10476-10477.
Impact Factor: 8.091
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Daniele A, Cardillo G, Pennino C, Carbone MT, Scognamiglio D, Esposito L, Correra A, Castaldo G, Zagari A, Salvatore F
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Impact Factor: 2.233
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Caraci F, Battaglia G, Busceti C, Biagioni F, Mastroiacovo F, Bosco P, Drago F, Nicoletti F, Sortino MA, Copani A
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Neurobiology Of Disease (ISSN: 0969-9961), 2008 May; 30(2): 234-242.
Impact Factor: 4.852
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De Simone A, Pedone C, Vitagliano L
* Structure, dynamics, and stability of assemblies of the human prion fragment SNQNNF (456 visite)
Biochem Biophys Res Commun (ISSN: 1090-2104, 0006-291x, 1090-2104electronic), 2008 Feb 15; 366(3): 800-806.
Impact Factor: 2.648
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Frasca F, Pandini G, Sciacca L, Pezzino V, Squatrito S, Belfiore A, Vigneri R
* The role of insulin receptors and IGF-I receptors in cancer and other diseases (1521 visite)
Archives Of Physiology And Biochemistry (ISSN: 1381-3455), 2008 Feb; 114(1): 23-37.
Impact Factor: 2.028
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Goldfine ID, Maddux BA, Youngren JF, Reaven G, Accili D, Trischitta V, Vigneri R, Frittitta L
* The role of membrane glycoprotein plasma cell antigen 1 ectonucleotide pyrophosphatase phosphodiesterase 1 in the pathogenesis of insulin resistance and related abnormalities (512 visite)
Endocrine Reviews (ISSN: 0163-769x), 2008 Feb; 29(1): 62-75.
Impact Factor: 18.562
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De Rosa A, Carducci C, Antonozzi I, Giovanniello T, Xhoxhi E, Criscuolo C, Menchise V, Striano S, Filla A, De Michele G
* A novel mutation in GCH-1 gene in a case of dopa-responsive dystonia [9] (288 visite)
J Neurol (ISSN: 0340-5354, 1432-1459, 1432-1459electronic), 2007 Sep; 254(8): 1133-1134.
Impact Factor: 2.477
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Cucinotta V, Giuffrida A, Grasso G, Maccarrone G, Messina M, Vecchio G
* High selectivity in new chiral separations of dansyl amino acids by cyclodextrin derivatives in electrokinetic chromatography (260 visite)
J Chromatogr A (ISSN: 0021-9673), 2007; 1155(2): 172-179.
Impact Factor: 3.641
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Menchise V, De Simone G, Di Fiore A, Scozzafava A, Supuran CT
* Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of 5-amino-1, 3, 4-thiadiazole-2-sulfonamide and 5-(4-amino-3-chloro-5-fluorophenylsulfonamido)1, 3, 4-thiadiazole-2-sulfon amide to human isoform II (285 visite)
Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2006 Dec 15; 16(24): 6204-6208.
Impact Factor: 2.538
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De Simone G, Vitale RM, Di Fiore A, Pedone C, Scozzafava A, Montero JL, Winum JY, Supuran CT
* Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX (445 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Sep 7; 49(18): 5544-5551.
Impact Factor: 5.115
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Alterio V, Vitale RM, Monti SM, Pedone C, Scozzafava A, Cecchi A, De Simone G, Supuran CT
* Carbonic anhydrase inhibitors: X-ray and molecular modeling study for the interaction of a fluorescent antitumor sulfonamide with isozyme II and IX (384 visite)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2006 Jun 28; 128(25): 8329-8335.
Impact Factor: 7.696
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De Capua A, Goodman M, Amino Y, Saviano M, Benedetti E
* Conformation analysis of aspartame-based sweeteners by NMR spectroscopy, molecular dynamics simulations, and X-ray diffraction studies (595 visite)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2006 Feb; 7(2): 377-387.
Impact Factor: 4.1
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Menchise V, De Simone G, Alterio V, Di Fiore A, Pedone C, Scozzafava A, Supuran CT
* Carbonic anhydrase inhibitors: Stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II (450 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2005 Sep 8; 48(18): 5721-5727.
Impact Factor: 4.926
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La Mendola D, Bonomo RP, Impellizzeri G, Maccarrone G, Pappalardo G, Pietropaolo A, Rizzarelli E, Zito V
* Copper(II) complexes with chicken prion repeats: Influence of proline and tyrosine residues on the coordination features (282 visite)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2005 Sep; 10(5): 463-475.
Impact Factor: 3.224
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Foti D, Chiefari E, Fedele M, Iuliano R, Brunetti L, Paonessa F, Manfioletti G, Barbetti F, Brunetti A, Croce CM, Fusco A, Brunetti A
* Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice (365 visite)
Nat Med (ISSN: 1078-8956, 0034-7264), 2005 Jul; 11(7): 765-773.
Impact Factor: 28.878
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La Rosa C, Milardi D, Amato E, Pappalardo M, Grasso D
* Molecular mechanism of the inhibition of cytochrome c aggregation by Phe-Gly (463 visite)
Arch Biochem Biophys (ISSN: 0003-9861), 2005 Mar 1; 435(1): 182-189.
Impact Factor: 3.152
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Iaccarino G, Ciccarelli M, Sorriento D, Galasso G, Campanile A, Santulli G, Cipolletta E, Cerullo V, Cimini V, Altobelli GG, Piscione F, Priante O, Pastore L, Chiariello M, Salvatore F, Koch WJ, Trimarco B
* Ischemic neoangiogenesis enhanced by β2-adrenergic receptor overexpression: A novel role for the endothelial adrenergic system (326 visite)
Circ Res (ISSN: 0009-7330, 1524-4571electronic), 2005; 97(11): 1182-1189.
Impact Factor: 9.408
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Saviano M, Improta R, Benedetti E, Carrozzini B, Cascarano GL, Didierjean C, Toniolo C, Crisma M
* Benzophenone photophore flexibility and proximity: Molecular and crystal-state structure of a Bpa-containing trichogin dodecapeptide analogue (365 visite)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2004 Apr 2; 5(4): 541-544.
Impact Factor: 3.474
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Cucinotta V, Giuffrida A, La Mendola D, Maccarrone G, Puglisi A, Rizzarelli E, Vecchio G
* 3-Amino Derivative Of Beta-Cyclodextrin: Thermodynamics Of Copper (ii) Complexes And Exploitation Of Its Enantioselectivity In The Separation Of Amino Acid Racemates By Ligand Exchange Capillary Electrophoresis (332 visite)
And Life Sciencesjournal Of Chromatography B Analytical Technologies In The Biomedical, 2004 Feb 5; 800(1-2): 127-133.
Impact Factor: 1.403
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Mansi R, Tesauro D, De Capua A, Fattorusso R, Carac C, Aloj L, Benedetti E, Morelli G
* Peptide-chelating agent conjugate for selective targeting of somatostatin receptor type 1: Synthesis and characterization (425 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 527-534.
Impact Factor: 2.863
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Palladino P, Pedone C, Ragone R, Rossi F, Saviano M, Benedetti E
* A simplified model of the binding interaction between stromal cell-derived factor-1 chemokine and CXC chemokine receptor (318 visite)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2003 Apr; 10(2): 133-138.
Impact Factor: 0.46
Dettagli Esporta in BibTeX Esporta in EndNote
Palladino P, De Capua A, Pedone C, Ragone R, Rossi F, Limatola C, Ragozzino D, Benedetti E
* A simplified model of the interaction between SDF-1 chemokine and the CXCR4 receptor (362 visite)
Peptide Revolution, 2003 Apr; 10(2): 133-138.
Impact Factor: 4.659
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Meyer Lindenberg A, Miletich RS, Kohn PD, Esposito G, Carson RE, Quarantelli M, Weinberger DR, Berman KF
* Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia (470 visite)
Nat Neurosci (ISSN: 1097-6256), 2002 Mar; 5(3): 267-271.
Impact Factor: 14.857
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Lauceri R, Raudino A, Scolaro LM, Micali N, Purrello R
* From achiral porphyrins to template-imprinted chiral aggregates and further. Self-replication of chiral memory from scratch (466 visite)
J Am Chem Soc (ISSN: 0002-7863print, 0002-7863linking, 1520-5126electronic), 2002 Feb 13; 120(47): 894-895.
Impact Factor: 9.023
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Maccarrone G, Nardin G, Randaccio L, Tabbì G, Rosi M, Sgamellotti A, Rizzarelli E, Zangrando E
Structure Of Copper(ii) Complexes With L-Leucyl-D-Phenylalanine Or L-Leucyl-L-Phenylalanine And Lcao-Scf-Mo Calculations On The Stabilization Of Copper(ii) Complexes Due To D-π Interaction With Aromatic Ring (337 visite)
Dalton Trans, 1996; N/D: 3449-3453.
Impact Factor: 0
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Bonomo RP, De Flora A, Rizzarelli E, Santoro AM, Tabbì G, Tonetti M
Copper(II) complexes encapsulated in human red blood cells (558 visite)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1995 Sep; 59(4): 773-784.
Impact Factor: 1.342
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FRITTITTA L, VIGNERI R, PAPA V, GOLDFINE I, GRASSO G, TRISCHITTA V
Structural and functional studies of insulin receptors in human breast cancer (401 visite)
Breast Cancer Res Tr Kluwer Academic Publishers (ISSN: 0167-6806), 1993; 25(1): 73-82.
Impact Factor: 2.43
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Papa V, Reese CC, Brunetti A, Vigneri R, Siiteri PK, Goldfine ID
Progestins increase insulin receptor content and insulin stimulation of growth in human breast carcinoma cells (416 visite)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1990 Dec 15; 50(24): 7858-7862.
Impact Factor: 8.426
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Trischitta V, Brunetti A, Chiavetta A, Benzi L, Papa V, Vigneri R
Defects in insulin-receptor internalization and processing in monocytes of obese subjects and obese NIDDM patients (285 visite)
Diabetesdiabetes (ISSN: 0012-1797), 1989 Dec; 38(12): 1579-1584.
Impact Factor: 8.675
Dettagli Esporta in BibTeX Esporta in EndNote
Pezzino V, Papa V, Trischitta V, Brunetti A, Goodman PA, Treutelaar MK, Williams JA, Maddux BA, Vigneri R, Goldfine ID
Human insulin receptor radioimmunoassay: Applicability to insulin-resistant states (237 visite)
Am J Physiol Endocrinol Metab (ISSN: 0002-9513), 1989 Sep; 257(3): N/D-N/D.
Impact Factor: 3.116
Dettagli Esporta in BibTeX Esporta in EndNote
Trischitta V, Wong KY, Brunetti A, Scalisi R, Vigneri R, Goldfine ID
Endocytosis, recycling, and degradation of the insulin receptor. Studies with monoclonal antireceptor antibodies that do not activate receptor kinase (304 visite)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 1989 Mar 25; 264(9): 5041-5046.
Impact Factor: 6.963
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Marletta F, Rizzarelli E, Mangiameli A, Brogna A, Sammartano S, Monaco S, Blasi A
Effects of graded doses of copper complexes of L-aminoacids on gastric acid secretion in rats (1273 visite)
Boll Soc Ital Biol Sper (ISSN: 0037-8771), 1979 Apr 30; 55(8): 769-775.
Impact Factor: 0
Dettagli Esporta in BibTeX Esporta in EndNote
63 Records (60 escludendo Abstract e Conferenze).
Impact factor totale: 315.066 (302.231 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 330.776 (324.732 escludendo Abstract e Conferenze).
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