Tyrosine phosphorylation of phosphoinositide-dependent kinase 1 by the insulin receptor is necessary for insulin metabolic signaling(409 views visite) Fiory F, Alberobello AT, Miele C, Oriente F, Esposito I, Corbo V, Ruvo M, Tizzano B, Rasmussen TE, Gammeltoft S, Formisano P, Beguinot F
Keywords Parole chiave: Glucose, Insulin, Insulin Receptor, Phenylalanine, Phosphatidylinositide, Phosphatidylinositol 3 Kinase, Phosphoinositide Dependent Kinase 1, Protein Kinase B, Protein Tyrosine Kinase, Threonine, Unclassified Drug, Amino Acid Substitution, Animal Cell, Article, Carboxy Terminal Sequence, Controlled Study, Enzyme Activation, Gene Deletion, Glucose Metabolism, Glucose Transport, In Vitro Study, Insulin Metabolism, Myoblast, Nonhuman, Priority Journal, Protein Expression, Protein Phosphorylation, Signal Transduction, Cultured, Intracellular Signaling Peptides And Proteins, Phosphoproteins, Protein-Serine-Threonine Kinases, Sequence Deletion,
Affiliations Affiliazioni: *** IBB - CNR ***
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Università degli Studi di Napoli Federico II, Naples, Italy Istituto di Biostrutture e Bioimmagini del CNR, Naples, Italy Department of Clinical Biochemistry, Glostrup Hospital, DK 2600 Glostrup, Denmark Mammalian Cell Technology, Novo Nordisk A/S, DK 2880 Bagsvaerd, Denmark
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Dutil, E.M., Toker, A., Newton, A.C., Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1) (1998) Curr. Biol., 8, pp. 1366-1375
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Wick, K.L., Liu, F., A new molecular target of insulin action: Regulating the pivotal PDK1 (2001) Curr. Drug Targets Immune Endocr. Metabol. Disord., 1, pp. 209-221
Williams, M.R., Arthur, J.S., Balendran, A., Van Der Kaay, J., Poli, V., Cohen, P., Alessi, D.R., The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells (2000) Curr. Biol., 10, pp. 439-448
Alessi, D. R., Kozlowski, M. T., Weng, Q. P., Morrice, N., Avruch, J., 3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro (1998) Curr. Biol., 8, pp. 69-8
Anderson, K. E., Coadwell, J., Stephens, L. R., Hawkins, P. T., Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B (1998) Curr. Biol., 8, pp. 684-691
Cantrell, D. A., Phosphoinositide 3-kinase signalling pathways (2001) J. Cell Sci., 114, pp. 1439-1445
Chou, M. M., Hou, W., Johnson, J., Graham, L. K., Lee, M. H., Chen, C. S., Newton, A. C., Toker, A., Regulation of protein kinase C zeta by PI 3-kinase and PDK-1 (1998) Curr. Biol., 8, pp. 1069-1077
Dong, L. Q., Liu, F., PDK2: The missing piece in the receptor tyrosine kinase signaling pathway puzzle (2005) Am. J. Physiol. Endocrinol. Metab., 289, pp. E187-E196
Dong, L. Q., Zhang, R., Langlais, P., He, H., Clark, M., Zhu, L., Liu, F., Primary structure, tissue distribution, and expression of mouse phosphoinositide-dependent protein kinase-1, a protein kinase that phosphorylates and activates protein kinase C (1999) J. Biol. Chem., 274, pp. 8117-8122
Dutil, E. M., Toker, A., Newton, A. C., Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1) (1998) Curr. Biol., 8, pp. 1366-1375
Fields, G. B., Noble, R. L., Solid phase peptide synthesis utilizing 9-fluorenylmethoxycarbonyl amino acids (1990) Int. J. Pept. Protein Res., 35, pp. 161-214
Foukas, L. C., Shepherd, P. R., Phosphoinositide 3-kinase: The protein kinase that time forgot (2004) Biochem. Soc. Trans., 32, pp. 330-331
Hresko, R. C., Murata, H., Mueckler, M., Phosphoinositide-dependent kinase-2 is a distinct protein kinase enriched in a novel cytoskeletal fraction associated with adipocyte plasma membranes (2003) J. Biol. Chem., 278, pp. 21615-21622
Kandel, E. S., Hay, N., The regulation and activities of the multi-functional serine/threonine kinase Akt/PKB (1999) Exp. Cell Res., 253, pp. 210-229
McManus, E. J., Collins, B. J., Ashby, P. R., Prescott, A. R., Murray-Tait, V., Armit, L. J., Arthur, J. S., Alessi, D. R., The in vivo role of PtdIns (3, 4, 5) P (3) binding to PDK1 PH domain defined by knockin mutation (2004) EMBO J., 23, pp. 2071-2082
Myers, M. G., Backer, J. M., Siddle, K., White, M. F., The insulin receptor functions normally in Chinese hamster ovary cells after truncation of the C terminus (1991) J. Biol. Chem., 266, pp. 10616-10623
Park, J., Hill, M. M., Hess, D., Brazil, D. P., Hofsteenge, J., Hemmings, B. A., Identification of tyrosine phosphorylation sites on 3-phosphoinositide- dependent protein kinase-1 and their role in regulating kinase activity (2001) J. Biol. Chem., 276, pp. 37459-37471
Piper, R. C., Hess, L. J., James, D. E., Differential sorting of two glucose transporters expressed in insulin-sensitive cells (1991) Am. J. Physiol., 260, pp. C570-C580
Ruderman, N. B., Kapeller, R., White, M. F., Cantley, L. C., Activation of phosphatidylinositol 3-kinase by insulin (1990) Proc. Natl. Acad. Sci. USA, 87, pp. 1411-1415
Sarbassov, D. D., Guertin, D. A., Ali, S. M., Sabatini, D. M., Phosphorylation and regulation of Akt/PKB by the Rictor-mTOR complex (2005) Science, 307, pp. 1098-1101
Simpson, I. A., Yver, D. R., Hissin, P. J., Wardzala, L. J., Karnieli, E., Salans, L. B., Cushman, S. W., Insulin-stimulated translocation of glucose transporters in the isolated rat adipose cells: Characterization of subcellular fractions (1983) Biochim. Biophys. Acta, 763, pp. 393-407
Van Horn, D. J., Myers Jr., M. G., Backer, J. M., Direct activation of the phosphatidylinositol 3 -kinase by the insulin receptor (1994) J. Biol. Chem., 269, pp. 29-32
Wick, K. L., Liu, F., A new molecular target of insulin action: Regulating the pivotal PDK1 (2001) Curr. Drug Targets Immune Endocr. Metabol. Disord., 1, pp. 209-221
Williams, M. R., Arthur, J. S., Balendran, A., Van Der Kaay, J., Poli, V., Cohen, P., Alessi, D. R., The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells (2000) Curr. Biol., 10, pp. 439-448
Tyrosine phosphorylation of phosphoinositide-dependent kinase 1 by the insulin receptor is necessary for insulin metabolic signaling
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