Home Ricerca Sedi Chi siamo Organigramma Personale Contatti Didattica Login Documenti EN
Progetti in evidenza
(Link esterno)

(1209 visite)

Fondo Europeo Pesca
(622 visite)

(Link esterno)

Fondazione Veronesi
(Link esterno)

(1094 visite)

(1186 visite)

(Link esterno)

(1329 visite)

(1090 visite)

(1028 visite)

MFAG Grant
(1134 visite)

(Link esterno)


Contiene: [X]      Estesa     Autori: [X]  Tipo di lavoro: [X]
Data iniziale: Data finale: [X]      Sede: Affiliazione IBB     
[Pulisci modulo]

Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (107 visite)

Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G

Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.

Tipo di articolo: Journal Article, Comparative Study, Research Support, Non-U. S. Gov'T,

Impact factor: 1.995, Impact factor a 5 anni: 1.817

Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-23044437134&partnerID=40&md5=c106ba137fd297901c611eaa015605eb

Parole chiave: β-Amyloid, σ1 Receptor Agonists, Neuronal Apoptosis, 1 Phenylcyclohexanecarboxylic Acid 2 Morpholinoethyl Ester, 2 (4 Morpholinethyl)1 Phenylcyclohexanecarboxylate, 2 [4 Methoxy 3 (2 Phenylethoxy)phenyl] N, N Dipropylethylamine, 7 Dinitro 2, 3 Quinoxalinedione, Amyloid Beta Protein[25-35], Carboxylic Acid Derivative, Dizocilpine, Methyl 2 [1 Adamantyl(methyl)amino] Methyl 1 Phenylcyclopropanecarboxylate, Mr 22, Opiate Agonist, Opiate Antagonist, Protein Bax, Sigma Receptor Ligand, Unclassified Drug, Alzheimer Disease, Animal Cell, Article, Cell Death, Controlled Study, Cytotoxicity, Drug Antagonism, Drug Synthesis, Neuroprotection, Nonhuman, Priority Journal, Amyloid Beta-Protein, Anisoles, Bcl-2-Associated X Protein, Blotting, Western, Cell Count, Cell Survival, Cultured, Cerebral Cortex, Dose-Response Relationship, Drug Interactions, Embryo, Excitatory Amino Acid Antagonists, Neuroprotective Agents, Peptide Fragments, Propylamines, Proto-Oncogene Proteins C-Bcl-2, Amyloid Beta-Peptides, Inhibitors, Pharmacology, Drug Effects, Cytology, Mammalian, Metabolism,


*** IBB - CNR ***
Department of Pharmaceutical Sciences, University of Catania, Catania, Italy
I.B.B., CNR-Catania, Catania, Italy
Cellular Neurobiology Research Branch, NIDA, NIH, Baltimore, MD, United States


Hardy, J., Selkoe, D.J., The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics (2002) Science, 297, pp. 353-35

Loo, D.T., Copani, A., Pike, C.J., Whittemore, E.R., Walencewicz, A.J., Cotman, C.W., Apoptosis is induced by beta-amyloid in cultured central nervous system neurons (1993) Proc Natl Acad Sci USA, 90, pp. 7951-7955

Smale, G., Nichols, N.R., Brady, D.R., Finch, C.E., Horton Jr., W.E., Evidence for apoptotic cell death in Alzheimer's disease (1995) Exp Neurol, 133, pp. 225-230

Caricasole, A., Copani, A., Caraci, F., Aronica, E., Rozemuller, A.J., Caruso, A., Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (2004) J Neurosci, 24, pp. 6021-6027

Guitart, X., Codony, X., Monroy, X., Sigma receptors: Biology and therapeutic potential (2004) Psychopharmacology, 174, pp. 301-319

Maurice, T., Beneficial effect of the sigma1 receptor agonist PRE-084 against the spatial learning deficits in aged rats (2001) Eur J Pharmacol, 431, pp. 223-227

Maurice, T., Su, T.P., Privat, A., Sigma1 (σ1) receptor agonists and neurosteroids attenuate β25-35-amyloid peptide-induced amnesia in mice through a common mechanism (1998) Neuroscience, 83, pp. 413-428

Urani, A., Romieu, P., Roman, F.J., Maurice, T., Enhanced antidepressant effect of sigma1 (σ) receptor agonists in beta(25-35)-amyloid peptide-treated mice (2002) Behav Brain Res, 134, pp. 239-247

Kume, T., Nishikawa, H., Taguchi, R., Hashino, A., Katsuki, H., Kaneko, S., Antagonism of NMDA receptors by sigma receptor ligands attenuates chemical ischemia-induced neuronal death in vitro (2002) Eur J Pharmacol, 455, pp. 91-100

Takahashi, H., Kirsch, J.R., Hashimoto, K., London, E.D., Koehler, R.C., PPBP [4-phenyl-1-(4-phenylbutyl) piperidine] decreases brain injury after transient focal ischemia in rats (1996) Stroke, 27, pp. 2120-2123

Copani, A., Condorelli, F., Caruso, A., Vancheri, C., Sala, A., Giuffrida Stella, A.M., Mitotic signaling by beta-amyloid causes neuronal death (1999) FASEB J, 13, pp. 2225-2234

Marrazzo, A., Prezzavento, O., Pappalardo, M.S., Bousquet, E., Iadanza, M., Pike, V.W., Synthesis of (+)- And(-)-cis-2-[(1-adamantylamino)-methyl]-1 phenylcyclopropane derivatives as high affinity probes for sigma1 and sigma2 binding sites (2002) Farmaco, 57, pp. 45-53

Chaki, S., Okuyama, S., Ogawa, S., Tanaka, M., Muramatsu, M., Nakazato, Solubilization and characterization of binding sites for [3H]NE-100, a novel and potent sigma 1 ligand, from guinea pig brain (1996) Life Sci, 59, pp. 1331-1340

Su, T.P., Wu, X.Z., Cone, E.J., Shukla, K., Gund, T.M., Sigma compounds derived from phencyclidine: Identification of PRE-084, a new, selective sigma ligand (1991) J Pharmacol Exp Ther, 259, pp. 543-550

Church, J., Fletcher, E.J., Blockade by sigma site ligands of high voltage-activated Ca2+ channels in rat and mouse cultured, hippocampal pyramidal neurons (1995) Br J Pharmacol, 116, pp. 2801-2810

Morin-Surun, M.P., Collin, T., Denavit-Saubié, M., Baulieu, E.-E., Monnet, F.P., Intracellular σ1 receptor modulates phospholipase C and protein kinase C activities in the brainstem (1999) Proc Natl Acad Sci USA, 96, pp. 8196-8199

Ovalle, S., Zamanillo, D., Andreu, F., Farre, A.J., Guitart, X., Fibroblast growth factor-2 is selectively modulated in the rat brain by E-5842, a preferential sigma-1 receptor ligand and putative atypical antipsychotic (2001) Eur J Neurosci, 13, pp. 909-915

Copani, A., Bruno, V., Battaglia, G., Leanza, G., Pellitteri, R., Activation of metabotropic glutamate receptors protects cultured neurons against apoptosis induced by beta-amyloid peptide (1995) Mol Pharmacol, 47, pp. 890-897

Xie, J., Guo, Q., Zhu, H., Wooten, M.W., Mattson, M.P., Protein kinase C iota protects neural cells against apoptosis induced by amyloid beta-peptide (2000) Brain Res Mol Brain Res, 82, pp. 107-113

Mattson, M.P., Tomaselli, K.J., Rydel, R.E., Calcium-destabilizing and neurodegenerative effects of aggregated beta-amyloid peptide are attenuated by basic FGF (1993) Brain Res, 621, pp. 35-49

Maurice, T., Improving Alzheimer's disease-related cognitive deficits with sigmal receptor agonists (2002) Drug News Perspect, 15, pp. 617-625

Prolonged exposure of cultured cortical neurons to the residue 25-35 fragment of β-amyloid protein, in the presence of dizocilpine, an antagonist of the N-methyl-D-aspartate receptor, and of 6,7-dinitroquinoxaline- 2,3-dione, an antagonist of α-amino-3-hydroxy-5-methylisoxazole-4- propionate receptors, resulted in the expression of the proapoptotic protein Bax and neuronal death. Beta-amyloid protein(25-35)-induced neuronal death was substantially attenuated by the σ1 receptor agonist 2-(4-morpholinethyl)1-phenylcyclohexanecarboxylate. The neuroprotective action of 2-(4-morpholinethyl)1-phenylcyclohexanecarboxylate was mimicked by the σ1 ligand methyl (1S,2R)-2-[1-adamantyl(methyl)amino]methyl-1- phenylcyclopropanecarboxylate and was antagonized by the σ1 receptor antagonist N,N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy)-phenyl]- ethylamine monohydrochloride. These results suggest that σ1 receptor agonists might function as neuroprotectant agents in Alzheimer's disease. © 2005 Lippincott Williams & Wilkins.
Nessun risultato.
Nessun risultato.

Contiene: [X]      Estesa     Autori: [X]  Tipo di lavoro: [X]
Data iniziale: Data finale: [X]      Sede: Affiliazione IBB     
[Pulisci modulo]

Supuran CT, Alterio V, Di Fiore A, D'Ambrosio K, Carta F, Monti SM, De Simone G
* Inhibition of carbonic anhydrase IX targets primary tumors, metastases, and cancer stem cells: Three for the price of one (44 visite)
Med Res Rev (ISSN: 1098-1128electronic, 0198-6325linking), 2018 Sep; 38(6): 1799-1836.
Impact Factor: 8.29
Dettagli    Esporta in BibTeX    Esporta in EndNote

Leggio GM, Catania MV, Puzzo D, Spatuzza M, Pellitteri R, Gulisano W, Torrisi SA, Giurdanella G, Piazza C, Impellizzeri AR, Gozzo L, Navarria A, Bucolo C, Nicoletti F, Palmeri A, Salomone S, Copani A, Caraci F, Drago F
* The antineoplastic drug flavopiridol reverses memory impairment induced by Amyloid-ss1-42 oligomers in mice (112 visite)
Pharmacol Res (ISSN: 1096-1186electronic, 1043-6618linking), 2016 Apr; 106: 10-20.
Impact Factor: 4.48
Dettagli    Esporta in BibTeX    Esporta in EndNote

Palladino P, Aura AM, Spoto G
* Surface plasmon resonance for the label-free detection of Alzheimer's β-amyloid peptide aggregation (161 visite)
Analytical And Bioanalytical Chemistry (ISSN: 1618-2642), 2016; 408(3): 849-854.
Impact Factor: 3.431
Dettagli    Esporta in BibTeX    Esporta in EndNote

Giuffrida ML, Tomasello F, Caraci F, Chiechio S, Nicoletti F, Copani A
* Beta-Amyloid monomer and insulin/IGF-1 signaling in Alzheimer's disease (151 visite)
Mol Neurobiol (ISSN: 0893-7648), 2012 Dec; 46(3): 605-613.
Impact Factor: 5.471
Dettagli    Esporta in BibTeX    Esporta in EndNote

De Simone G, Supuran CT
* (In)organic anions as carbonic anhydrase inhibitors (133 visite)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2012 Jun; 111: 117-129.
Impact Factor: 3.197
Dettagli    Esporta in BibTeX    Esporta in EndNote

Calafiore M, Copani A, Deng W
* DNA polymerase-β mediates the neurogenic effect of β-amyloid protein in cultured subventricular zone neurospheres (154 visite)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2012 Mar; 90(3): 559-567.
Impact Factor: 2.974
Dettagli    Esporta in BibTeX    Esporta in EndNote

Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (234 visite)
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
Impact Factor: 3.677
Dettagli    Esporta in BibTeX    Esporta in EndNote

Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (267 visite)
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
Impact Factor: 4.883
Dettagli    Esporta in BibTeX    Esporta in EndNote

Ciaccio C, Tundo GR, Grasso G, Spoto G, Marasco D, Ruvo M, Gioia M, Rizzarelli E, Coletta M
* Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity (135 visite)
J Mol Biol (ISSN: 1089-8638, 0022-2836, 1089-8638electronic), 2009 Feb 6; 385(5): 1556-1567.
Impact Factor: 3.871
Dettagli    Esporta in BibTeX    Esporta in EndNote

Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA
* The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (128 visite)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
Impact Factor: 4.823
Dettagli    Esporta in BibTeX    Esporta in EndNote

Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
* The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (124 visite)
Biochim Biophys Acta (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
Impact Factor: 3.078
Dettagli    Esporta in BibTeX    Esporta in EndNote

Giuffrida ML, Grasso G, Ruvo M, Pedone C, Saporito A, Marasco D, Pignataro B, Cascio C, Copani A, Rizzarelli E
* Abeta(25-35) And Its C- And/Or N-Blocked Derivatives: Copper Driven Structural Features And Neurotoxicity (156 visite)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Feb 15; 85(3): 623-633.
Impact Factor: 3.268
Dettagli    Esporta in BibTeX    Esporta in EndNote

Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
* Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (140 visite)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2006; 26(43): 10949-10957.
Impact Factor: 2.117
Dettagli    Esporta in BibTeX    Esporta in EndNote

Calafiore M, Battaglia G, Zappal A, Trovato-Salinaro E, Caraci F, Caruso M, Vancheri C, Sortino MA, Nicoletti F, Copani A
* Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to β-amyloid (93 visite)
Neurobiol Aging (ISSN: 0197-4580, 1558-1497electronic), 2006; 27(4): 606-613.
Impact Factor: 5.599
Dettagli    Esporta in BibTeX    Esporta in EndNote

Filippo C, Mariangela C, Giuseppina F, Pier Luigi C, Angelo B, Marco C, Giuseppe B, Paolo B, Ferdinando N, Agata C, Maria Angela S
* Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against β-amyloid toxicity (249 visite)
Brain Res (ISSN: 0006-8993), 2005; 1047(1): 30-37.
Impact Factor: 2.296
Dettagli    Esporta in BibTeX    Esporta in EndNote

Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F
* Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (125 visite)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2004 Jun 30; 24(26): 6021-6027.
Impact Factor: 2.384
Dettagli    Esporta in BibTeX    Esporta in EndNote

Formaggio F, Bonchio M, Crisma M, Peggion C, Mezzato S, Polese A, Barazza A, Antonello S, Maran F, Broxterman QB, Kaptein B, Kamphuis J, Vitale RM, Saviano M, Benedetti E, Toniolo C
* Nitroxyl peptides as catalysts of enantioselective oxidations (143 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2002; 8(1): [d]84-93.
Impact Factor: 4.238
Dettagli    Esporta in BibTeX    Esporta in EndNote

17 Records (17 escludendo Abstract e Conferenze).
Impact factor totale: 68.077 (68.077 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 63.636 (63.636 escludendo Abstract e Conferenze).

    Esporta in BibTeX    Esporta in EndNote

Ultima modifica di Marco Comerci in data Thursday 19 March 2015, 17:16:33
107 visite. Ultima visita in data Friday 28 December 2018, 2:28:25

Webmaster and developer: Marco Comerci
Per problemi e suggerimenti: adminibb.cnr.it
Ultimo aggiornamento: Friday 15 February 2019, 13:06:47