Benzophenone photophore flexibility and proximity: Molecular and crystal-state structure of a Bpa-containing trichogin dodecapeptide analogue(343 views visite) Saviano M, Improta R, Benedetti E, Carrozzini B, Cascarano GL, Didierjean C, Toniolo C, Crisma M
Keywords Parole chiave: Conformation Analysis, Donor-Acceptor Systems, Helical Structures, Lipopeptaibol Antibiotic, X-Ray Diffraction, Benzophenone, Peptide Derivative, 4 Benzoylphenylalanine, 4-Benzoylphenylalanine, Antiinfective Agent, Benzophenone Derivative, Drug Derivative, Glycopeptide, Oligopeptide, Trichogin Ga Iv, Article, Chemical Structure, Crystal Structure, Hydrogen Bond, Molecular Interaction, Priority Journal, Protein Protein Interaction, X Ray Diffraction, Chemistry, Crystallization, Photochemistry, Pliability, X Ray Crystallography, Anti-Bacterial Agents, Hydrogen Bonding, Models, Molecular Structure,
Affiliations Affiliazioni: *** IBB - CNR ***
Inst. of Biostructures/Bioimaging, CNR, via Mezzocannone 6, 80134 Napoli, Italy Department of Biological Chemistry, Universita di Napoli Federico II, via Mezzocannone 6, 80134 Napoli, Italy Institute of Crystallography, Department of Geomineralogy, University Campus, 70125 Bari, Italy Groupe de Biocristallographie, Universite Henri Poincare Nancy I, Faculté des Sciences, B.P. 239, 54506 Vandoeuvre-les-Nancy Cedex, France Institute of Biomolecular Chemistry, Department of Organic Chemistry, Università di Padova, via Marzolo 1, 35131 Padova, Italy
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Benzophenone photophore flexibility and proximity: Molecular and crystal-state structure of a Bpa-containing trichogin dodecapeptide analogue
Up close and flexible: An X-ray diffraction analysis of a Bpa-containing analogue of the lipopeptaibol trichogin GA IV strongly points to the conclusion that caution should be exercised in utilizing this highly flexible, benzophenone-based photoprobe acritically in biochemical and biophysical studies. As a result of the different side-chain conformations adopted by the Bpa residue, the distance of its ketone carbonyl carbon from the midpoint of the N-O bond of the nitroxide-containing side chain of the TOAC residue in the two crystallographically independent peptide molecules differs by as much as 11 Å as shown in the figure.
Benzophenone photophore flexibility and proximity: Molecular and crystal-state structure of a Bpa-containing trichogin dodecapeptide analogue
113 Records (111 escludendo Abstract e Conferenze). Impact factor totale: 363.206 (355.739 escludendo Abstract e Conferenze). Impact factor a 5 anni totale: 408.224 (400.552 escludendo Abstract e Conferenze).
Last modified by Ultima modifica di Marco Comerci on in data Sunday 12 July 2020, 13:15:10 343 views visite. Last view on Ultima visita in data Wednesday 24 February 2021, 23:56:45