Eukaryotic cell signaling and transcriptional activation induced by bacterial porins (340 views visite)
Fems Microbiology Letters (ISSN: 0378-1097), 2003 Sep 12; 226(1): 57-64.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article,
Impact factor: 1.932, 5-year impact factor Impact factor a 5 anni: 2.448
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0642338941&partnerID=40&md5=7b3be2e0cfc939c6d1e424a9aa84d701
Keywords Parole chiave: Porin, Signal Transduction Pathway, Bacterial Antigen, Outer Membrane Protein, 2 (2 Amino 3 Methoxyphenyl)chromone, 4 (4 Fluorophenyl) 2 (4 Methylsulfinylphenyl) 5 (4 Pyridyl)imidazole, Bacterium Lipopolysaccharide, Forskolin, Immunoglobulin Enhancer Binding Protein, Mitogen Activated Protein Kinase 1, Mitogen Activated Protein Kinase Inhibitor, Permease, Raf Protein, Stress Activated Protein Kinase, Toll Like Receptor, Transcription Factor Ap 1, Animal, Eukaryotic Cell, Genetic Transcription, Gram Negative Bacterium, Human, Immunology, Metabolism, Microbiology, Physiology, Review, Transactivation, Bacterial Membrane, Gram Negative Infection, Host Cell, Host Pathogen Interaction, Nonhuman, Pathogenesis, Priority Journal, Protein Function, Protein Interaction, Protein Structure, Short Survey, Transcription Initiation, Bacterial Outer Membrane Proteins, Gram-Negative Bacteria, Trans-Activation (genetics), Bacteria (microorganisms), Negibacteria, 2 (2 Amino 3 Methoxyphenyl) Chromone, 4 (4 Fluorophenyl) 2 (4 Methylsulfinylphenyl) 5 (4 Pyridyl) Imidazole,
Affiliations Affiliazioni:
*** IBB - CNR ***
Dipto. di Medicina Sperimentale, Sezione Microbiol. Microbiol. Clin., Seconda Univ. degli Studi di Napoli, Via De Crecchio 7, 80138 Naples, Italy
Ctro. Interuniversitario Ric. Sui P., Univ. di Napoli 'Federico II', Via Mezzocannone 6-8, 80134 Naples, Italy
Dipartimento di Chimica Biologica, Ist. Biostrutture Bioimmagini - CNR, Univ. di Napoli 'Federico II', Via Mezzocannone, 80134 Naples, Italy
References Riferimenti:
Schulz, G.E., The structure of bacterial outer membrane proteins (2002) Biochim. Biophys. Acta, 1565, pp. 308-31
Koebnik, R., Locker, K.P., Van Gelder, P., Structure and function of bacterial outer membrane proteins: Barrels in a nutshell (2000) Mol. Microbiol., 37, pp. 239-253
Nikaido, H., Vaara, M., Outer membrane (1987) Escherichia coli and Salmonella typhimurium: Cellular and Molecular Biology, 1, pp. 7-22. , (Neidhardt, F.C., Ingraham, J.L., Low, K.B., Magasanik, B., Schaechter M. and Umbarger, H.E., Eds.), American Society for Microbiology, Washington, DC
Galdiero, F., Tufano, M.A., Galdiero, M., Masiello, S., Di Rosa, M., Inflammatory effects of Salmonella typhimurium porins (1990) Infect. Immun., 58, pp. 3183-3186
Vordermeier, H.M., Drexler, H., Bessler, W.G., Polyclonal activationof human peripheral blood lymphocytes by bacterial porins and defined porin fragments (1987) Immunol. Lett., 15, pp. 121-126
Massari, P., Ram, S., MacLeod, H., Wetzler, L.M., The role of porins in neisserial pathogenesis and immunity (2003) Trends Microbiol., 11, pp. 87-93
Galdiero, F., Sommese, L., Scarfogliero, P., Galdiero, M., Biological activities - Lethality, Shwartzman reaction and pyrogenicity - Of Salmonella typhimurium porins (1994) Microb. Pathogen., 16, pp. 111-119
Donnarumma, G., Brancaccio, F., Cipollaro De L'Ero, G., Folgore, A., Marcatili, A., Galdiero, M., Release of GM-CSF, sE-selectin and sICAM-1 by human vascular endothelium stimulated with gram-negative and gram-positive bacterial components (1996) Endothelium, 4, pp. 11-12
Galdiero, M., Folgore, A., Molitierno, M., Greco, R., Porins and lipopolysaccharide (LPS) from Salmonella typhimurium induce leukocyte transmigration through human endothelial cells in vitro (1999) Clin. Exp. Immunol., 116, pp. 453-461
Galdiero, F., Cipollaro De L'Ero, G., Benedetto, N., Galdiero, M., Tufano, M.A., Release of cytokines induced by Salmonella typhimurium porins (1993) Infect. Immun., 61, pp. 155-161
Henderson, B., Poole, S., Wilson, M., Bacterial modulins: A novel class of virulence factors which cause host tissue pathology by inducing cytokine synthesis (1996) Microbiol. Rev., 60, pp. 316-341
Galdiero, M., Palomba, E., De Martino, L., Vitiello, M., Pagnini, P., Effects of the major Pasteurella multocida porin on bovine neutrophils (1998) Am. J. Vet. Res., 59, pp. 1270-1274
Los, M., Wesselborg, S., Schulze-Osthoff, K., The role of caspases in development, immunity, and apoptotic signal transduction: Lesson from knockout mice (1999) Immunity, 10, pp. 629-639
Cory, S., Adams, J.M., The Bcl-2 family: Regulators of the cellular life-or-death switch (2002) Nat. Rev. Cancer, 2, pp. 647-656
Massari, P., Ho, Y., Wetzler, L.M., Neisseria meningitidis porin PorB interacts with mitochondrial and protects cells from apoptosis (2000) Proc. Natl. Acad. Sci. USA, 97, pp. 9070-9075
Alberti, S., Marques, G., Camprubi, S., Merino, S., Tomas, J.M., Vivanco, F., Benedi, V.J., C1q binding and activation of the complement classical pathway by Klebsiella pneumoniae outer membrane proteins (1993) Infect. Immun., 61, pp. 852-860
Alberti, S., Rodriquez-Quinones, F., Schirmer, T., Rummel, G., Tomas, J.M., Rosenbusch, J.P., Benedi, V.J., A porin from Klebsiella pneumoniae: Sequence homology, three-dimensional model, and complement binding (1995) Infect. Immun., 63, pp. 903-910
Neary, J.M., Yi, K., Karalus, R.J., Murphy, T.F., Antibodies to loop 6 of the P2 porin protein of nontypeable Haemophilus influenzae are bactericidal against multiple strains (2001) Infect. Immun., 69, pp. 773-778
Ram, S., McQuillen, D.P., Gulati, S., Elkins, C., Pangburn, M.K., Rice, P.A., Binding of complement factor H to loop 5 of porin protein 1A: A molecular mechanism of serum resistance of nonsialylated Neisseria gonorrhoeae (1998) J. Exp. Med., 188, pp. 671-680
Ram, S., Cullinane, M., Blom, A.M., Gulati, S., McQuillen, D.P., Monks, B.G., O'Connel, C., Rice, P.A., Binding of C4b-binding protein to porin: A molecular mechanism of serum resistance of Neisseria gonorrhoeae (2001) J. Exp. Med., 193, pp. 281-295
Wetzler, L.M., Immunopotentiating ability of neisserial major outer membrane proteins. Use as an adjuvant for poorly immunogenic substances and potential use in vaccines (1994) Ann. NY Acad. Sci., 730, pp. 367-370
Wetzler, L.M., Ho, Y., Reiser, H., Wetzler, L.W., Neisserial porins induce B lymphocytes to express costimulatory B7-2 molecules and to proliferate (1996) J. Exp. Med., 183, pp. 1151-1159
Matsui, K., Arai, T., The comparison of cell-mediated immunity induced by immunization with porin, viable cells and killed cells of Salmonella typhimurium (1992) Microbiol. Immunol., 36, pp. 269-278
Srikumar, R., Dahan, D., Gras, M.F., Saarinen, L., Kayhty, H., Sarvas, M., Vogel, L., Coulton, J.W., Immunological properties of recombinant porin of Haemophilus influenzae type b expressed in Bacillus subtilis (1993) Infect. Immun., 61, pp. 3334-3341
Sengupta, D.K., Sengupta, T.K., Ghose, A.C., Major outer membrane proteins of Vibrio cholerae and their role in induction of protective immunity through inhibition of intestinal colonization (1992) Infect. Immun., 60, pp. 4848-4855
Simpson, S.C., Ho, Y., Rice, P.A., Wetzler, L.M., T lymphocyte response to Neisseria gonorrhoeae porin in individuals with mucosal gonococcal infections (1999) J. Infect. Dis., 180, pp. 762-773
Galdiero, M., De Martino, L., Marcatili, A., Nuzzo, I., Vitiello, M., Cipollaro De L'Ero, G., Th1 and Th2 cell involvement in immune response to Salmonella typhimurium porins (1998) Immunology, 94, pp. 5-13
Wright, S.D., Ramos, R.A., Tobias, P.S., Ulevitch, R.J., Mathison, J.C., CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein (1990) Science, 249, pp. 1431-1433
Ingalls, R.R., Golenbock, D.T., CD11c/CD18, a transmembrane signaling receptor for lipopolysaccharide (1995) J. Exp. Med., 181, pp. 1473-1479
Hoshino, K., Takeuchi, O., Kawai, T., Sanjo, H., Ogawa, T., Takeda, Y., Takeda, K., Akira, S., Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product (1999) J. Immunol., 162, pp. 3749-3752
Massari, P., Henneke, P., Ho, Y., Latz, E., Golenbock, D.T., Wetzler, L.M., Cutting edge: Immune stimulation by neisserial porins is toll-like receptor 2 and MyD88 dependent (2002) J. Immunol., 168, pp. 1533-1537
Werling, D., Jungi, T.W., TOLL-like receptors linking innate and adaptive immune response (2003) Vet. Immun. Immunopathol., 91, pp. 1-12
An, H., Yu, Y., Zhang, M., Xu, H., Qi, R., Yan, X., Liu, S., Cao, X., Involvement of ERK, p38 and NF-kappaB signal transduction in regulation of TLR2, TLR4 and TLR9 gene expression induced by lipopolysaccharide in mouse dendritic cells (2002) Immunology, 106, pp. 38-45
Shuto, T., Xu, H., Wang, B., Han, J., Kai, H., Gu, X.X., Murphy, T., Li, J.D., Activation of NF-kappa B by nontypeable Haemophilus influenzae is mediated by toll-like receptor 2-TAK1-dependent NIK-IKK alpha/beta-I kappa B alpha and MKK3/6-p38 MAPkinase signaling pathways in epithelial cells (2001) Proc. Natl. Acad. Sci. USA, 98, pp. 8774-8779
Galdiero, M., D'Isanto, M., Vitiello, M., Finamore, E., Peluso, L., Galdiero, M., Porins from Salmonella enterica serovar Typhimurium induce TNF-alpha, IL-6 and IL-8 release by CD14-independent and CD11a/CD18-dependent mechanisms (2001) Microbiology, 147, pp. 2697-2704
Galdiero, F., Cioffi, S., Mattera, S., Galdiero, M., Tufano, M.A., Fluorescent detection of interactions of porins, lipopolysaccharides, muramic-acid and N-acetyl-muramyl-L-alanyl-D-isoglutamine with cell membrane (1993) Immunol. Infect. Dis., 3, pp. 27-31
Galdiero, M., Brancaccio, F., Nazzaro, C., De Martino, L., Salmonella typhimurium porin internalization by leukocytes (1998) Res. Microbiol., 149, pp. 625-630
Merz, A.J., So, M., Interactions of pathogenic Neisseriae with epithelial cell membranes (2000) Annu. Rev. Cell Dev. Biol., 16, pp. 423-457
Evans, D.J., Frank, D.W., Finck-Barbancon, V., Wu, C., Fleiszig, S.M., Pseudomonas aeruginosa invasion and cytotoxicity are independent events, both of which involve protein tyrosine kinase activity (1998) Infect. Immun., 66, pp. 1453-1459
Rosenshine, I., Donnenberg, M.S., Kaper, J.B., Finlay, B.B., Signal transduction between enteropathogenic Escherichia coli (EPEC) and epithelial cells: EPEC induces tyrosine phosphorylation of host cell proteins to initiate cytoskeletal rearrangement and bacterial uptake (1992) EMBO J., 11, pp. 3551-3560
Weinstein, S.L., Sanghera, J.S., Lemke, K., Defranco, A.L., Pelech, S.L., Bacterial lipopolysaccharide induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in macrophages (1992) J. Biol. Chem., 267, pp. 14955-14962
Bhat, N.R., Zhang, P., Lee, J.C., Hogan, E.L., Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures (1998) J. Neurosci., 18, pp. 1633-1641
Davis, R.J., Signal transduction by the JNK group of MAP kinases (2000) Cell, 103, pp. 239-252
Karin, M., Liu, Z., Zandi, E., AP-1 function and regulation (1997) Curr. Opin. Cell Biol., 9, pp. 240-246
Caamano, J., Hunter, C.A., NF-κB family of transcription factors: Central regulators of innate and adaptive immune functions (2002) Clin. Microbiol. Rev., 15, pp. 419-429
Gupta, S., Kumar, D., Vohra, H., Ganguly, N.K., Involvement of signal transduction pathways in Salmonella typhimurium porin activated gut macrophages (1999) Mol. Cell. Biochem., 194, pp. 235-243
Galdiero, M., Vitiello, M., D'Isanto, M., Peluso, L., Galdiero, M., Induction of tyrosine phosphorylated proteins in THP-1 cells by Salmonella typhimurium, Pasteurella haemolytica and Haemophilus influenzae porins (2001) FEMS Immunol. Med. Microbiol., 31, pp. 121-130
Procyk, K.J., Kovarik, P., Von Gabain, A., Baccarini, M., Salmonella typhimurium and lipopolysaccharide stimulate extracellularly regulated kinase activation in macrophages by a mechanism involving phosphatidylinositol 3-kinase and phospholipase D as novel intermediates (1999) Infect. Immun., 67, pp. 1011-1017
Beaty, C.D., Franklin, T.L., Uehara, Y., Wilson, C.B., Lipopolysaccharide-induced cytokine production in human monocytes: Role of tyrosine phosphorylation in transmembrane signal transduction (1994) Eur. J. Immunol., 24, pp. 1278-1284
Li, S., Sedivy, J.M., Raf-1 protein kinase activates the NF-kappa B transcription factor by dissociating the cytoplasmic NF-kappa B-I kappa B complex (1993) Proc. Natl. Acad. Sci. USA, 90, pp. 9247-9251
Galdiero, S., Capasso, D., Vitiello, M., D'Isanto, M., Pedone, C., Galdiero, M., Role of surface-exposed loops of Haemophilus influenzae protein P2 in the mitogen-activated protein kinase cascade (2003) Infect. Immun., 71, pp. 2798-2809
Schulz, G. E., The structure of bacterial outer membrane proteins (2002) Biochim. Biophys. Acta, 1565, pp. 308-31
Vordermeier, H. M., Drexler, H., Bessler, W. G., Polyclonal activationof human peripheral blood lymphocytes by bacterial porins and defined porin fragments (1987) Immunol. Lett., 15, pp. 121-126
Cory, S., Adams, J. M., The Bcl-2 family: Regulators of the cellular life-or-death switch (2002) Nat. Rev. Cancer, 2, pp. 647-656
Neary, J. M., Yi, K., Karalus, R. J., Murphy, T. F., Antibodies to loop 6 of the P2 porin protein of nontypeable Haemophilus influenzae are bactericidal against multiple strains (2001) Infect. Immun., 69, pp. 773-778
Wetzler, L. M., Immunopotentiating ability of neisserial major outer membrane proteins. Use as an adjuvant for poorly immunogenic substances and potential use in vaccines (1994) Ann. NY Acad. Sci., 730, pp. 367-370
Wetzler, L. M., Ho, Y., Reiser, H., Wetzler, L. W., Neisserial porins induce B lymphocytes to express costimulatory B7-2 molecules and to proliferate (1996) J. Exp. Med., 183, pp. 1151-1159
Sengupta, D. K., Sengupta, T. K., Ghose, A. C., Major outer membrane proteins of Vibrio cholerae and their role in induction of protective immunity through inhibition of intestinal colonization (1992) Infect. Immun., 60, pp. 4848-4855
Simpson, S. C., Ho, Y., Rice, P. A., Wetzler, L. M., T lymphocyte response to Neisseria gonorrhoeae porin in individuals with mucosal gonococcal infections (1999) J. Infect. Dis., 180, pp. 762-773
Wright, S. D., Ramos, R. A., Tobias, P. S., Ulevitch, R. J., Mathison, J. C., CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein (1990) Science, 249, pp. 1431-1433
Ingalls, R. R., Golenbock, D. T., CD11c/CD18, a transmembrane signaling receptor for lipopolysaccharide (1995) J. Exp. Med., 181, pp. 1473-1479
Merz, A. J., So, M., Interactions of pathogenic Neisseriae with epithelial cell membranes (2000) Annu. Rev. Cell Dev. Biol., 16, pp. 423-457
Evans, D. J., Frank, D. W., Finck-Barbancon, V., Wu, C., Fleiszig, S. M., Pseudomonas aeruginosa invasion and cytotoxicity are independent events, both of which involve protein tyrosine kinase activity (1998) Infect. Immun., 66, pp. 1453-1459
Weinstein, S. L., Sanghera, J. S., Lemke, K., Defranco, A. L., Pelech, S. L., Bacterial lipopolysaccharide induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in macrophages (1992) J. Biol. Chem., 267, pp. 14955-14962
Bhat, N. R., Zhang, P., Lee, J. C., Hogan, E. L., Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures (1998) J. Neurosci., 18, pp. 1633-1641
Davis, R. J., Signal transduction by the JNK group of MAP kinases (2000) Cell, 103, pp. 239-252
Procyk, K. J., Kovarik, P., Von Gabain, A., Baccarini, M., Salmonella typhimurium and lipopolysaccharide stimulate extracellularly regulated kinase activation in macrophages by a mechanism involving phosphatidylinositol 3-kinase and phospholipase D as novel intermediates (1999) Infect. Immun., 67, pp. 1011-1017
Beaty, C. D., Franklin, T. L., Uehara, Y., Wilson, C. B., Lipopolysaccharide-induced cytokine production in human monocytes: Role of tyrosine phosphorylation in transmembrane signal transduction (1994) Eur. J. Immunol., 24, pp. 1278-1284
Li, S., Sedivy, J. M., Raf-1 protein kinase activates the NF-kappa B transcription factor by dissociating the cytoplasmic NF-kappa B-I kappa B complex (1993) Proc. Natl. Acad. Sci. USA, 90, pp. 9247-9251
Fems Microbiology Letters (ISSN: 0378-1097), 2003 Sep 12; 226(1): 57-64.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article,
Impact factor: 1.932, 5-year impact factor Impact factor a 5 anni: 2.448
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0642338941&partnerID=40&md5=7b3be2e0cfc939c6d1e424a9aa84d701
Keywords Parole chiave: Porin, Signal Transduction Pathway, Bacterial Antigen, Outer Membrane Protein, 2 (2 Amino 3 Methoxyphenyl)chromone, 4 (4 Fluorophenyl) 2 (4 Methylsulfinylphenyl) 5 (4 Pyridyl)imidazole, Bacterium Lipopolysaccharide, Forskolin, Immunoglobulin Enhancer Binding Protein, Mitogen Activated Protein Kinase 1, Mitogen Activated Protein Kinase Inhibitor, Permease, Raf Protein, Stress Activated Protein Kinase, Toll Like Receptor, Transcription Factor Ap 1, Animal, Eukaryotic Cell, Genetic Transcription, Gram Negative Bacterium, Human, Immunology, Metabolism, Microbiology, Physiology, Review, Transactivation, Bacterial Membrane, Gram Negative Infection, Host Cell, Host Pathogen Interaction, Nonhuman, Pathogenesis, Priority Journal, Protein Function, Protein Interaction, Protein Structure, Short Survey, Transcription Initiation, Bacterial Outer Membrane Proteins, Gram-Negative Bacteria, Trans-Activation (genetics), Bacteria (microorganisms), Negibacteria, 2 (2 Amino 3 Methoxyphenyl) Chromone, 4 (4 Fluorophenyl) 2 (4 Methylsulfinylphenyl) 5 (4 Pyridyl) Imidazole,
Affiliations Affiliazioni:
*** IBB - CNR ***
Dipto. di Medicina Sperimentale, Sezione Microbiol. Microbiol. Clin., Seconda Univ. degli Studi di Napoli, Via De Crecchio 7, 80138 Naples, Italy
Ctro. Interuniversitario Ric. Sui P., Univ. di Napoli 'Federico II', Via Mezzocannone 6-8, 80134 Naples, Italy
Dipartimento di Chimica Biologica, Ist. Biostrutture Bioimmagini - CNR, Univ. di Napoli 'Federico II', Via Mezzocannone, 80134 Naples, Italy
References Riferimenti:
Schulz, G.E., The structure of bacterial outer membrane proteins (2002) Biochim. Biophys. Acta, 1565, pp. 308-31
Koebnik, R., Locker, K.P., Van Gelder, P., Structure and function of bacterial outer membrane proteins: Barrels in a nutshell (2000) Mol. Microbiol., 37, pp. 239-253
Nikaido, H., Vaara, M., Outer membrane (1987) Escherichia coli and Salmonella typhimurium: Cellular and Molecular Biology, 1, pp. 7-22. , (Neidhardt, F.C., Ingraham, J.L., Low, K.B., Magasanik, B., Schaechter M. and Umbarger, H.E., Eds.), American Society for Microbiology, Washington, DC
Galdiero, F., Tufano, M.A., Galdiero, M., Masiello, S., Di Rosa, M., Inflammatory effects of Salmonella typhimurium porins (1990) Infect. Immun., 58, pp. 3183-3186
Vordermeier, H.M., Drexler, H., Bessler, W.G., Polyclonal activationof human peripheral blood lymphocytes by bacterial porins and defined porin fragments (1987) Immunol. Lett., 15, pp. 121-126
Massari, P., Ram, S., MacLeod, H., Wetzler, L.M., The role of porins in neisserial pathogenesis and immunity (2003) Trends Microbiol., 11, pp. 87-93
Galdiero, F., Sommese, L., Scarfogliero, P., Galdiero, M., Biological activities - Lethality, Shwartzman reaction and pyrogenicity - Of Salmonella typhimurium porins (1994) Microb. Pathogen., 16, pp. 111-119
Donnarumma, G., Brancaccio, F., Cipollaro De L'Ero, G., Folgore, A., Marcatili, A., Galdiero, M., Release of GM-CSF, sE-selectin and sICAM-1 by human vascular endothelium stimulated with gram-negative and gram-positive bacterial components (1996) Endothelium, 4, pp. 11-12
Galdiero, M., Folgore, A., Molitierno, M., Greco, R., Porins and lipopolysaccharide (LPS) from Salmonella typhimurium induce leukocyte transmigration through human endothelial cells in vitro (1999) Clin. Exp. Immunol., 116, pp. 453-461
Galdiero, F., Cipollaro De L'Ero, G., Benedetto, N., Galdiero, M., Tufano, M.A., Release of cytokines induced by Salmonella typhimurium porins (1993) Infect. Immun., 61, pp. 155-161
Henderson, B., Poole, S., Wilson, M., Bacterial modulins: A novel class of virulence factors which cause host tissue pathology by inducing cytokine synthesis (1996) Microbiol. Rev., 60, pp. 316-341
Galdiero, M., Palomba, E., De Martino, L., Vitiello, M., Pagnini, P., Effects of the major Pasteurella multocida porin on bovine neutrophils (1998) Am. J. Vet. Res., 59, pp. 1270-1274
Los, M., Wesselborg, S., Schulze-Osthoff, K., The role of caspases in development, immunity, and apoptotic signal transduction: Lesson from knockout mice (1999) Immunity, 10, pp. 629-639
Cory, S., Adams, J.M., The Bcl-2 family: Regulators of the cellular life-or-death switch (2002) Nat. Rev. Cancer, 2, pp. 647-656
Massari, P., Ho, Y., Wetzler, L.M., Neisseria meningitidis porin PorB interacts with mitochondrial and protects cells from apoptosis (2000) Proc. Natl. Acad. Sci. USA, 97, pp. 9070-9075
Alberti, S., Marques, G., Camprubi, S., Merino, S., Tomas, J.M., Vivanco, F., Benedi, V.J., C1q binding and activation of the complement classical pathway by Klebsiella pneumoniae outer membrane proteins (1993) Infect. Immun., 61, pp. 852-860
Alberti, S., Rodriquez-Quinones, F., Schirmer, T., Rummel, G., Tomas, J.M., Rosenbusch, J.P., Benedi, V.J., A porin from Klebsiella pneumoniae: Sequence homology, three-dimensional model, and complement binding (1995) Infect. Immun., 63, pp. 903-910
Neary, J.M., Yi, K., Karalus, R.J., Murphy, T.F., Antibodies to loop 6 of the P2 porin protein of nontypeable Haemophilus influenzae are bactericidal against multiple strains (2001) Infect. Immun., 69, pp. 773-778
Ram, S., McQuillen, D.P., Gulati, S., Elkins, C., Pangburn, M.K., Rice, P.A., Binding of complement factor H to loop 5 of porin protein 1A: A molecular mechanism of serum resistance of nonsialylated Neisseria gonorrhoeae (1998) J. Exp. Med., 188, pp. 671-680
Ram, S., Cullinane, M., Blom, A.M., Gulati, S., McQuillen, D.P., Monks, B.G., O'Connel, C., Rice, P.A., Binding of C4b-binding protein to porin: A molecular mechanism of serum resistance of Neisseria gonorrhoeae (2001) J. Exp. Med., 193, pp. 281-295
Wetzler, L.M., Immunopotentiating ability of neisserial major outer membrane proteins. Use as an adjuvant for poorly immunogenic substances and potential use in vaccines (1994) Ann. NY Acad. Sci., 730, pp. 367-370
Wetzler, L.M., Ho, Y., Reiser, H., Wetzler, L.W., Neisserial porins induce B lymphocytes to express costimulatory B7-2 molecules and to proliferate (1996) J. Exp. Med., 183, pp. 1151-1159
Matsui, K., Arai, T., The comparison of cell-mediated immunity induced by immunization with porin, viable cells and killed cells of Salmonella typhimurium (1992) Microbiol. Immunol., 36, pp. 269-278
Srikumar, R., Dahan, D., Gras, M.F., Saarinen, L., Kayhty, H., Sarvas, M., Vogel, L., Coulton, J.W., Immunological properties of recombinant porin of Haemophilus influenzae type b expressed in Bacillus subtilis (1993) Infect. Immun., 61, pp. 3334-3341
Sengupta, D.K., Sengupta, T.K., Ghose, A.C., Major outer membrane proteins of Vibrio cholerae and their role in induction of protective immunity through inhibition of intestinal colonization (1992) Infect. Immun., 60, pp. 4848-4855
Simpson, S.C., Ho, Y., Rice, P.A., Wetzler, L.M., T lymphocyte response to Neisseria gonorrhoeae porin in individuals with mucosal gonococcal infections (1999) J. Infect. Dis., 180, pp. 762-773
Galdiero, M., De Martino, L., Marcatili, A., Nuzzo, I., Vitiello, M., Cipollaro De L'Ero, G., Th1 and Th2 cell involvement in immune response to Salmonella typhimurium porins (1998) Immunology, 94, pp. 5-13
Wright, S.D., Ramos, R.A., Tobias, P.S., Ulevitch, R.J., Mathison, J.C., CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein (1990) Science, 249, pp. 1431-1433
Ingalls, R.R., Golenbock, D.T., CD11c/CD18, a transmembrane signaling receptor for lipopolysaccharide (1995) J. Exp. Med., 181, pp. 1473-1479
Hoshino, K., Takeuchi, O., Kawai, T., Sanjo, H., Ogawa, T., Takeda, Y., Takeda, K., Akira, S., Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product (1999) J. Immunol., 162, pp. 3749-3752
Massari, P., Henneke, P., Ho, Y., Latz, E., Golenbock, D.T., Wetzler, L.M., Cutting edge: Immune stimulation by neisserial porins is toll-like receptor 2 and MyD88 dependent (2002) J. Immunol., 168, pp. 1533-1537
Werling, D., Jungi, T.W., TOLL-like receptors linking innate and adaptive immune response (2003) Vet. Immun. Immunopathol., 91, pp. 1-12
An, H., Yu, Y., Zhang, M., Xu, H., Qi, R., Yan, X., Liu, S., Cao, X., Involvement of ERK, p38 and NF-kappaB signal transduction in regulation of TLR2, TLR4 and TLR9 gene expression induced by lipopolysaccharide in mouse dendritic cells (2002) Immunology, 106, pp. 38-45
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Eukaryotic cell signaling and transcriptional activation induced by bacterial porins
The protein composition of the outer membrane of Gram-negative bacteria consists of about 20 immunochemically distinct proteins, termed outer membrane proteins (OMPs). Apart from their structural role, OMPs have been shown to have other functions, particularly with regard to transport, and have been classified as permeases and porins. Porins, during their interaction with the host, are immunogenic and also directly stimulate several cellular functions. Porins work both as molecules present on the bacterial surface and as molecules released by bacteria. Lipopolysaccharide and OMPs, the major structural macromolecular constituents of the outer membrane, carry out a fundamental role in the pathogenesis of Gram-negative infections. This brief review describes the multiple facets of the biological activities of porins both in vitro and in vivo, particularly focusing on their ability to induce the expression of cytokines and other factors that modulate cellular activities with either pathological or adaptive consequences. This brief discussion will focus on the signal transmission mechanisms induced by bacterial porins. (C) 2003 Published by Elsevier B.V. on behalf of the Federation of European Microbiological Societies.
The protein composition of the outer membrane of Gram-negative bacteria consists of about 20 immunochemically distinct proteins, termed outer membrane proteins (OMPs). Apart from their structural role, OMPs have been shown to have other functions, particularly with regard to transport, and have been classified as permeases and porins. Porins, during their interaction with the host, are immunogenic and also directly stimulate several cellular functions. Porins work both as molecules present on the bacterial surface and as molecules released by bacteria. Lipopolysaccharide and OMPs, the major structural macromolecular constituents of the outer membrane, carry out a fundamental role in the pathogenesis of Gram-negative infections. This brief review describes the multiple facets of the biological activities of porins both in vitro and in vivo, particularly focusing on their ability to induce the expression of cytokines and other factors that modulate cellular activities with either pathological or adaptive consequences. This brief discussion will focus on the signal transmission mechanisms induced by bacterial porins. (C) 2003 Published by Elsevier B.V. on behalf of the Federation of European Microbiological Societies.
Eukaryotic cell signaling and transcriptional activation induced by bacterial porins
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Eukaryotic cell signaling and transcriptional activation induced by bacterial porins
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Impact Factor: 1.826
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Grund ME, Choi SJ, Mcnitt DH, Barbier M, Hu G, Lasala PR, Cote CK, Berisio R, Lukomski S
* Burkholderia collagen-like protein 8, Bucl8, is a unique outer membrane component of a putative tetrapartite efflux pump in Burkholderia pseudomallei and Burkholderia mallei (18 visite)
Plos One (ISSN: 1932-6203linking), 2020 Nov 23; 15(11): e0242593-N/D.
Impact Factor: 2.74
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Wong J, Romano M, Kerry LE, Kwong H, Low W, Brett S, J , Clements A, Beis K, Frankel G
OmpK36-mediated Carbapenem resistance attenuates ST258 Klebsiella pneumoniae in vivo (92 visite)
Nature Communications, 2019 Sep; N/D: N/D-N/D.
Impact Factor: 12.121
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Magri A, Di Rosa MC, Tomasello MF, Guarino F, Reina S, Messina A, De Pinto V
* Overexpression of human SOD1 in VDAC1-less yeast restores mitochondrial functionality modulating beta-barrel outer membrane protein genes (311 visite)
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 1570-9639print), 2016 Mar 4; 1857(6): 789-798.
Impact Factor: 4.932
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Ciccarelli M, Rusciano MR, Sorriento D, Maione AS, Soprano M, Iaccarino G, Illario M
* Messages from the Border: Novel Insights in Signal Transduction Pathways Involved in Tumor Invasion and Metastasis (212 visite)
Journal Of Cancer Therapy (ISSN: 2151-1934), 2015 Feb 11; 6: 199-212.
Impact Factor: 0.56
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Tornatore L, Sandomenico A, Raimondo D, Low C, Rocci A, Tralau-Stewart C, Capece D, D'Andrea D, Bua M, Boyle E, van Duin M, Zoppoli P, Jaxa-Chamiec A, Thotakura AK, Dyson J, Walker BA, Leonardi A, Chambery A, Driessen C, Sonneveld P, Morgan G, Palumbo A, Tramontano A, Rahemtulla A, Ruvo M, Franzoso G
* Cancer-selective targeting of the NF-kappaB survival pathway with GADD45beta/MKK7 inhibitors (518 visite)
Cancer Cell (ISSN: 1535-6108), 2014 Oct 13; 26(4): 495-508.
Impact Factor: 23.523
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Sorriento D, Fusco A, Ciccarelli M, Rungi A, Anastasio A, Carillo A, Dorn II GW, Trimarco B, Iaccarino G
* Mitochondrial G protein coupled receptor kinase 2 regulates proinflammatory responses in macrophages (317 visite)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2013; 587(21): 3487-3494.
Impact Factor: 3.341
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Galdiero S, Falanga A, Cantisani M, Tarallo R, della Pepa ME, D'Oriano V, Galdiero M
* Microbe-Host Interactions: Structure and Role of Gram-Negative Bacterial Porins (292 visite)
Curr Protein Pept Sci (ISSN: 1389-2037), 2012 Dec; 13(8): 843-854.
Impact Factor: 2.326
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Calabrese V, Cornelius C, Dinkova-Kostova AT, Iavicoli I, Di Paola R, Koverech A, Cuzzocrea S, Rizzarelli E, Calabrese EJ
* Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity (2140 visite)
Bba-Gen Subjects (ISSN: 0006-3002, 0925-4439, 1570-9639), 2012 May; 1822(5): 753-783.
Impact Factor: 3.733
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Galdiero S, Vitiello M, Finamore E, Mansi R, Galdiero M, Morelli G, Tesauro D
* Activation of monocytic cells by immunostimulatory lipids conjugated to peptide antigens (331 visite)
Molecular Biosystems (ISSN: 1742-206x), 2012; 8(12): 3166-3177.
Impact Factor: 3.35
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Vitiello M, Galdiero M, Finamore E, Galdiero S, Galdiero M
* NF-κB as a potential therapeutic target in microbial diseases (347 visite)
Mol Biosyst (ISSN: 1742-206x), 2012; 8(4): 1108-1120.
Impact Factor: 3.35
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Cantisani M, Vitiello M, Falanga A, Finamore E, Galdiero M, Galdiero S
* Peptides complementary to the active loop of porin P2 from Haemophilus influenzae modulate its activity (426 visite)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1178-2013electronic), 2012; 7: 2361-2371.
Impact Factor: 3.463
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Palmieri G, Bergamo P, Luini A, Ruvo M, Gogliettino M, Langella E, Saviano M, Hegde RN, Sandomenico A, Rossi M
* Acylpeptide hydrolase inhibition as targeted strategy to induce proteasomal down-regulation (363 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2011 Oct 10; 6(10): e25888-e25888.
Impact Factor: 4.092
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Calabrese V, Cornelius C, Cuzzocrea S, Iavicoli I, Rizzarelli E, Calabrese EJ
* Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity (512 visite)
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 279-304.
Impact Factor: 9.97
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Janda E, Palmieri C, Pisano A, Pontoriero M, Iaccino E, Falcone C, Fiume G, Gaspari M, Nevolo M, Di Salle E, Rossi A, De Laurentiis A, Greco A, Di Napoli D, Verheij E, Britti D, Lavecchia L, Quinto I, Scala G
* Btk regulation in human and mouse B cells via protein kinase C phosphorylation of IBtkγ (307 visite)
Blood (ISSN: 0006-4971, 0006-6497, 0390-6078), 2011 Jun 16; 117(24): 6520-6531.
Impact Factor: 9.898
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Barile E, Leone M, Barile E, Dahl R, Pellecchia M
* Design and NMR Studies of Cyclic Peptides Targeting the N-Terminal Domain of the Protein Tyrosine Phosphatase YopH (2122 visite)
Chem Biol Drug Des Chemical Biology And Drug Design (ISSN: 1747-0277, 1747-0285), 2011 Jan; 77(1): 12-19.
Impact Factor: 2.282
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Ciccarelli M, Sorriento D, Cipolletta E, Santulli G, Fusco A, Zhou R-H, Eckhart AD, Peppel K, Koch WJ, Trimarco B, Iaccarino G
* Impaired neoangiogenesis in β2-adrenoceptor gene-deficient mice: Restoration by intravascular human β2-adrenoceptor gene transfer and role of NFkB and CREB transcription factors (320 visite)
Br J Pharmacol British Journal Of Pharmacology (ISSN: 0007-1188), 2011; 162(3): 712-721.
Impact Factor: 4.409
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Leone M, Barile E, Vazquez J, Mei A, Guiney D, Dahl R, Pellecchia M
* NMR-based design and evaluation of novel bidentate inhibitors of the protein tyrosine phosphatase YopH (372 visite)
Chem Biol Drug Des Chemical Biology And Drug Design (ISSN: 1747-0277, 1747-0285), 2010 Jul; 76(1): 10-16.
Impact Factor: 2.527
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Romano S, D'Angelillo A, Pacelli R, Staibano S, De Luna E, Bisogni R, Eskelinen EL, Mascolo M, Calì G, Arra C, Romano M
* Role of FK506-binding protein 51 in the control of apoptosis of irradiated melanoma cells (302 visite)
Cell Death Differ (ISSN: 1350-9047, 1476-5403electronic, 1350-9047linking), 2010 Jan; 17(1): 145-157.
Impact Factor: 9.05
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Sorriento D, Santulli G, Fusco A, Anastasio A, Trimarco B, Iaccarino G
* Intracardiac injection of AdGRK5-NT reduces left ventricular hypertrophy by inhibiting NF-κB-Dependent hypertrophic gene expression (327 visite)
Hypertensionhypertension (ISSN: 0194-911x), 2010; 56(4): 696-704.
Impact Factor: 6.908
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Sorriento D, Iaccarino G, Trimarco B
The role of the transcription factor nuclear factor kappa B in the regulation of cardiac hypertrophy (302 visite)
High Blood Press Cardiovasc Prev High Blood Pressure And Cardiovascular Prevention (ISSN: 1120-9879), 2010; 17(4): 209-217.
Impact Factor: 0
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Vitiello M, Finamore E, Falanga A, Raieta K, Cantisani M, Galdiero F, Pedone C, Galdiero M, Galdiero S
* Viral fusion peptides induce several signal transduction pathway activations that are essential for interleukin-10 and beta-interferon production (399 visite)
Intervirology (ISSN: 1423-0100, 0300-5526), 2010; 53(6): 381-389.
Impact Factor: 1.756
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Marasco D, Stilo R, Sandomenico A, Monti SM, Tizzano B, De Capua A, Varricchio E, Liguoro D, Zotti T, Formisano S, Ruvo M, Vito P
* Generation And Functional Characterization Of A Bcl10-Inhibitory Peptide That Represses Nf-Kappa B Activation (331 visite)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2009 Sep 15; 422(3): 553-561.
Impact Factor: 5.155
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Sandomenico A, Monti SM, Sabatella M, De Capua A, Tornatore L, Doti N, Viparelli F, Dathan NA, Pedone C, Ruvo M, Marasco D
* Protein-protein interactions: a simple strategy to identify binding sites and peptide antagonists (395 visite)
Chem Biol Drug Des Chemical Biology And Drug Design (ISSN: 1747-0285, 1747-0277), 2009 May; 73(5): 483-493.
Impact Factor: 2.473
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Sorriento D, Campanile A, Santulli G, Leggiero E, Pastore L, Trimarco B, Iaccarino G
* A new synthetic protein, TAT-RH, inhibits tumor growth through the regulation of NFκB activity (297 visite)
Mol Cancermolecular Cancer (ISSN: 1476-4598), 2009; 8: N/D-N/D.
Impact Factor: 4.16
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Chiechio S, Zammataro M, Morales ME, Busceti CL, Drago F, Th Gereau RW, Copani A, Nicoletti F
* Epigenetic modulation of mGlu2 receptors by histone deacetylase inhibitors in the treatment of inflammatory pain (308 visite)
Mol Pharmacol (ISSN: 0026-895x), 2009; 75(5): 1014-1020.
Impact Factor: 4.531
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Calabrese V, Cornelius C, Mancuso C, Pennisi G, Calafato S, Bellia F, Bates TE, Giuffrida Stella AM, Schapira T, Dinkova Kostova AT, Rizzarelli E
* Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity (651 visite)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2008 Dec; 33(12): 2444-2471.
Impact Factor: 2.26
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Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, Galasso G, Astone D, Piscione F, Pastore L, Trimarco B, Iaccarino G
* The G-protein-coupled receptor kinase 5 inhibits NFκB transcriptional activity by inducing nuclear accumulation of IκBα (312 visite)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2008; 105(46): 17818-17823.
Impact Factor: 9.38
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Galdiero S, Galdiero M, Pedone C
* Beta-Barrel Membrane Bacterial Proteins: Structure, Function, Assembly And Interaction With Lipids (304 visite)
Curr Protein Pept Sci (ISSN: 1389-2037), 2007 Feb; 8(1): 63-82.
Impact Factor: 3.259
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Borgatti M, Finotti A, Romanelli A, Saviano M, Bianchi N, Lampronti I, Lambertini E, Penolazzi L, Nastruzzi C, Mischiati C, Piva R, Pedone C, Gambari R
* Peptide nucleic acids (PNA)-DNA chimeras targeting transcription factors as a tool to modify gene expression (426 visite)
Curr Drug Targets (ISSN: 1389-4501), 2004 Nov; 5(8): 735-744.
Impact Factor: 4.104
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Mischiati C, Sereni A, Finotti A, Breda L, Cortesi R, Nastruzzi C, Romanelli A, Saviano M, Bianchi N, Pedone C, Borgatti M, Gambari R
* Complexation to cationic microspheres of double-stranded peptide nucleic acid-DNA chimeras exhibiting decoy activity (293 visite)
Journal Of Biomedical Science (ISSN: 1021-7770), 2004 Sep; 11(5): 697-704.
Impact Factor: 1.567
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Penolazzi L, Borgatti M, Lambertini E, Mischiati C, Finotti A, Romanelli A, Saviano M, Pedone C, Piva R, Gambari R
* Peptide nucleic acid-DNA decoy chimeras targeting NF-kappa B transcription factors: Induction of apoptosis in human primary osteoclasts (281 visite)
International Journal Of Molecular Medicine (ISSN: 1107-3756), 2004 Sep; 14(2): 145-152.
Impact Factor: 3.19
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Galdiero S, Vitiello M, D'Isanto M, Di Niola E, Peluso L, Raieta K, Pedone C, Galdiero M, Benedetti E
* Induction of signaling pathways by herpes simplex virus type 1 through glycoprotein H peptides (533 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 494-502.
Impact Factor: 2.863
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Galdiero S, Capasso D, Vitiello M, D'Isanto M, Pedone C, Galdiero M
* Protein P2 from Haemophilus influenzae: The role of its surface exposed loops on the mitogen-activated protein kinase cascade (303 visite)
Infection And Immunity (ISSN: 0019-9567), 2003 May; 71(5): 2798-2809.
Impact Factor: 3.875
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Borgatti M, Romanelli A, Saviano M, Pedone C, Lampronti I, Breda L, Nastruzzi C, Bianchi N, Mischiati C, Gambari R
* Resistance of decoy PNA-DNA chimeras to enzymatic degradation in cellular extracts and serum (258 visite)
Oncology Research (ISSN: 0965-0407), 2003; 13(5): 279-287.
Impact Factor: 1.794
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Borgatti M, Breda L, Cortesi R, Nastruzzi C, Romanelli A, Saviano M, Bianchi N, Mischiati C, Pedone C, Gambari R
* Cationic Liposomes As Delivery Systems For Double-Stranded Pna-Dna Chimeras Exhibiting Decoy Activity Against Nf-Kappab Transcription Factors (346 visite)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 1873-2968, 0006-2952), 2002 Sep 15; 64(4): 609-616.
Impact Factor: 3.542
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Romanelli A, Pedone C, Saviano M, Bianchi N, Borgatti M, Mischiati C, Gambari R
* Molecular interactions between nuclear factor κB (NF-κB) transcription factors and a PNA-DNA chimera mimicking NF-κB binding sites (315 visite)
Eur J Biochem (ISSN: 0014-2956, 0014-2956print, 0014-2956linking), 2001 Dec; 268(23): 6066-6075.
Impact Factor: 2.849
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Vitiello M, Finamore E, Falanga A, Raieta K, Cantisani M, Galdiero F, Pedone C, Galdiero M, Galdiero S
* Fusion in Coq (399 visite)
Lecture Notes In Computer Science (ISSN: 0302-9743, 0302-974335404636319783540463634, 0302-974335402975459783540297543), 2001; 2178LNCS: 583-596.
Impact Factor: 0.415
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Saviano M, Romanelli A, Bucci E, Pedone C, Mischiati C, Bianchi N, Feriotto G, Borgatti M, Gambari R
Computational procedures to explain the different biological activity of DNA/DNA, DNA/PNA and PNA/PNA hybrid molecules mimicking NF-κB binding sites (426 visite)
J Biomol Struct Dyn (ISSN: 0739-1102, 1538-0254electronic, 0739-1102linking), 2000 Dec; 18(3): 353-362.
Impact Factor: 1.826
Dettagli Esporta in BibTeX Esporta in EndNote
38 Records (38 escludendo Abstract e Conferenze).
Impact factor totale: 171.574 (171.574 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 184.507 (184.507 escludendo Abstract e Conferenze).
Impact factor totale: 171.574 (171.574 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 184.507 (184.507 escludendo Abstract e Conferenze).
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