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Complete Response To Preoperative Chemoradiation And Survival In Esophageal Cancer: A Pooled Analysis Of Three Single-Institution Phase Ii Trials (157 visite)

Orditura M, Galizia G, Morgillo F, Martinelli E, Lieto E, Vitiello F, Di Martino N, Pacelli R, Renda A, Ciardiello F, De Vita F

Diseases Of The Esophagus, 2012 Feb; 142(5): 130-136.



Tipo di articolo: Letter, Journal Article,

Impact factor: 2.057, Impact factor a 5 anni: 2.005

Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84857113777&partnerID=40&md5=97910941a8218bdc62cf539ac71b35cb

Parole chiave: Esophageal Cancer, Pooled Analysis, Preoperative Chemoradiotherapy, Cetuximab, Cisplatin, Fluorouracil, Folinic Acid, Oxaliplatin, Paclitaxel, Adult, Article, Cancer Combination Chemotherapy, Cancer Radiotherapy, Cancer Survival, Clinical Effectiveness, Continuous Infusion, Esophageal Adenocarcinoma, Esophageal Squamous Cell Carcinoma, Female, Histopathology, Human, Human Tissue, Major Clinical Study, Multiple Cycle Treatment, Outcome Assessment, Overall Survival, Phase 2 Clinical Trial, Preoperative Treatment, Priority Journal, Radiation Dose, Treatment Response, Antineoplastic Combined Chemotherapy Protocols, Esophageal Neoplasms, Middle Aged, Preoperative Period, Remission Induction, Survival Analysis, Treatment Outcome, Forced Vital Capacity, Letter, Mortality, Reference Value, Risk Assessment, Risk Factor, Total Lung Capacity,

Affiliazioni:

*** IBB - CNR ***
Division of Medical Oncology, Department of Clinical and Experimental Medicine and Surgery 'F. Magrassi - A. Lanzara', Second University of Naples School of Medicine, Italy
Division of Surgical Oncology, Department of Clinical and Experimental Medicine and Surgery 'F. Magrassi - A. Lanzara', Second University of Naples School of Medicine, Italy
Division of Radiotherapy, Federico II University of Naples School of Medicine, Naples, Italy
Division of General Surgery, Federico II University of Naples School of Medicine, Naples, Italy
Unit of Respiratory Pathophysiology, Universit Campus Biomedico, Via Alvaro del Portillo, 200, 00128 Rome, Italy
Alberto Sordi Foundation, Rome, Italy
Department of Epidemiology, Roma E. Health Authority, Rome, Italy
Fondazione San Raffaele, Cittadella della Carit, Taranto, Italy



Riferimenti:

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Siewert, J. R., Stein, H. J., Feith, M., Bruecher, B. L., Bartels, H., Fink, U., Histologic tumor type is an independent prognostic parameter in esophageal cancer: lessons from more than 1, 000 consecutive resections at a single center in the Western world (2001) Ann Surg, 234, pp. 360-369

Walsh, T. N., Noonan, N., Hollywood, D., Kelly, A., Keeling, N., Hennessy, T. P., A comparison of multimodal therapy and surgery for adenocarcinoma (1996) N Engl J Med, 335, pp. 462-467

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Urschel, J. D., Vasan, H., A meta-analysis of randomized controlled trials that compared neoadjuvant chemoradiation and surgery to surgery alone for resectable esophageal cancer (2003) Am J Surg, 185, pp. 538-543

Fiorica, F., Camm, C., Venturi, A., A preoperative chemotherapy and radiotherapy in patients with esophageal carcinoma: a meta-analysis (2004) Gut, 53, pp. 925-930

Gebsky, V., Burmeister, B., Smithers, B. M., Foo, K., Zalcberg, J., Simes, J., Survival benefit from neoadjuvant chemoradiotherapy or chemotherapy in esophageal carcinoma: a meta-analysis (2007) Lancet Oncol, 8, pp. 226-234

Graham, A. J., Scrive, F. M., Ghali, A., Defining the optimal treatment of locally advanced esophageal cancer: a systematic review and decision analysis (2007) Ann Thorac Surg, 83, pp. 1257-1264

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Berger, A. C., Farma, J., Scott, W. J., Complete response to neoadjuvant chemoradiotherapy in esophageal carcinoma is associated with significantly improved survival (2005) J Clin Oncol, 23, pp. 4330-4337

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Bosset, J., Gignoux, M., Triboulet, J., Chemoradiotherapy followed by surgery compared with surgery alone in squamous-cell cancer of the esophagus (1997) N Engl J Med, 337, pp. 161-167

Urba, S. G., Orringer, M. B., Turrisi, A., Iannettoni, M., Forastiere, A., Strawderman, M., Randomized trial of preoperative chemoradiation versus surgery alone in patients with locoregional esophageal carcinoma (2001) J Clin Oncol, 19, pp. 305-313

Lee, J. L., Park, S. I., Kim, S. B., A single institutional phase III trial of preoperative chemotherapy with hyperfractionation radiotherapy plus surgery versus surgery alone for resectable esophageal squamous cell carcinoma (2004) Ann Oncol, 15, pp. 947-954

Burmeister, B. H., Smithers, B. M., Gebski, V., Surgery alone versus chemoradiotherapy followed by surgery for resectable cancer of the oesophagus: a randomised controlled phase III trial (2005) Lancet Oncol, 6, pp. 659-668

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De Vita, F., Di Martino, N., Orditura, M., Preoperative chemoradiotherapy for squamous cell and adenocarcinoma of the esophagus: A phase II study (2002) Chest, 122, pp. 1302-1308

Orditura, M., Galizia, G., Napolitano, V., Weekly chemotherapy with cisplatin and paclitaxel and concurrent radiation therapy as preoperative treatment in locally advanced esophageal cancer (2010) Cancer Invest, 28, pp. 820-827

De Vita, F., Orditura, M., Martinelli, E., Neoadjuvant chemoradiation with FOLFOX 4 and Cetuximab in esophageal cancer: B152 phase II trial final results (2011) Br J Cancer, 104, pp. 427-432

Chan, Y. H., Biostatistics 203. Survival analysis (2004) Singapore Med J, 45, pp. 249-256

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Geh, J. I., Crellin, A. M., Glynne-Jones, R., Preoperative (neoadjuvant) chemoradiotherapy in oesophageal cancer (2001) Br J Surg, 88, pp. 338-356

Rice, T. W., Rusch, V. W., Apperson-Hansen, C., Worldwide esophageal cancer collaboration (2009) Dis Esophagus, 22, pp. 1-8

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Geh, J. I., Bond, S. J., Bentzen, S. M., Glynne-Jones, R., Systematic overview of preoperative (neoadjuvant) chemoradiation trials in oesophageal cancer: evidence of a radiation and chemotherapy dose-response (2006) Radiother Oncol, 78, pp. 236-244

Parkin, D.M., Bray, F.I., Devesa, S.S., Cancer burden in the year 2000. The global picture (2001) Eur J Cancer, 37 (8 SUPPL.), pp. 64-6

Siewert, J.R., Stein, H.J., Feith, M., Bruecher, B.L., Bartels, H., Fink, U., Histologic tumor type is an independent prognostic parameter in esophageal cancer: lessons from more than 1,000 consecutive resections at a single center in the Western world (2001) Ann Surg, 234, pp. 360-369

Walsh, T.N., Noonan, N., Hollywood, D., Kelly, A., Keeling, N., Hennessy, T.P., A comparison of multimodal therapy and surgery for adenocarcinoma (1996) N Engl J Med, 335, pp. 462-467

Urschel, J.D., Vasan, H., A meta-analysis of randomized controlled trials that compared neoadjuvant chemoradiation and surgery to surgery alone for resectable esophageal cancer (2003) Am J Surg, 185, pp. 538-543

Fiorica, F., Cammà, C., Venturi, A., A preoperative chemotherapy and radiotherapy in patients with esophageal carcinoma: a meta-analysis (2004) Gut, 53, pp. 925-930

Graham, A.J., Scrive, F.M., Ghali, A., Defining the optimal treatment of locally advanced esophageal cancer: a systematic review and decision analysis (2007) Ann Thorac Surg, 83, pp. 1257-1264

Lv, J., Cao, X.F., Zhu, B., Tao, L., Wang, D.D., Effect of neoadjuvant chemoradiotherapy on prognosis and surgery for esophageal carcinoma (2009) World J Gastroenterol, 15, pp. 4962-4968

Berger, A.C., Farma, J., Scott, W.J., Complete response to neoadjuvant chemoradiotherapy in esophageal carcinoma is associated with significantly improved survival (2005) J Clin Oncol, 23, pp. 4330-4337

Urba, S.G., Orringer, M.B., Turrisi, A., Iannettoni, M., Forastiere, A., Strawderman, M., Randomized trial of preoperative chemoradiation versus surgery alone in patients with locoregional esophageal carcinoma (2001) J Clin Oncol, 19, pp. 305-313

Lee, J.L., Park, S.I., Kim, S.B., A single institutional phase III trial of preoperative chemotherapy with hyperfractionation radiotherapy plus surgery versus surgery alone for resectable esophageal squamous cell carcinoma (2004) Ann Oncol, 15, pp. 947-954

Burmeister, B.H., Smithers, B.M., Gebski, V., Surgery alone versus chemoradiotherapy followed by surgery for resectable cancer of the oesophagus: a randomised controlled phase III trial (2005) Lancet Oncol, 6, pp. 659-668

Chan, Y.H., Biostatistics 203. Survival analysis (2004) Singapore Med J, 45, pp. 249-256

Gaast, A.V., van Hagen, P., Hulshof, M., Effect of preoperative concurrent chemoradiotherapy on survival of patients with resectable esophageal or esophagogastric junction cancer: results from a multicenter randomized phase III study (2010) J Clin Oncol, 28 (SUPPL.), pp. 15s. , abstract 4004)

Geh, J.I., Crellin, A.M., Glynne-Jones, R., Preoperative (neoadjuvant) chemoradiotherapy in oesophageal cancer (2001) Br J Surg, 88, pp. 338-356

Rice, T.W., Rusch, V.W., Apperson-Hansen, C., Worldwide esophageal cancer collaboration (2009) Dis Esophagus, 22, pp. 1-8

Geh, J.I., Bond, S.J., Bentzen, S.M., Glynne-Jones, R., Systematic overview of preoperative (neoadjuvant) chemoradiation trials in oesophageal cancer: evidence of a radiation and chemotherapy dose-response (2006) Radiother Oncol, 78, pp. 236-244



This pooled analysis was performed using individual patient data from three phase II trials that included on the whole 113 esophageal cancer treated preoperatively with chemoradiotherapy (CRT), in order to analyze the efficacy and survival outcomes according to the achievement of the pathologic complete response (pCR). Thirty-nine patients were treated with 5-fluorouracil/cisplatin and RT (40Gy), 33 patients received paclitaxel/cisplatin weekly during weeks 1-6 with and RT (46Gy), 41 patients were treated with induction bio-chemotherapy with cetuximab and FOLFOX-4 followed by concomitant cetuximab and RT of 50. 4Gy. One hundred and two out of 113 resected patients were included in the survival analysis. The median overall survival (OS) time for the whole population was 21. 5 months. The 12, 24, and 36 months OS rates were 85. 4, 45. 2, and 33%, respectively. The difference in survival probability between patients with pCR and patients with partial response or stable disease after treatment was significant (P= 0. 0002, hazard ratios = 0. 21, 95% CI 0. 18-0. 60). On multivariate analysis, the pathologic response and histology were the only covariates independently associated with OS (P= 0. 0157 and P= 0. 0212, respectively). In our series, complete responder patients had a significant longer survival probability after treatment when compared to patients with partial response or stable disease. 2011 the Authors. Journal compilation 2011, Wiley Periodicals, Inc. and the International Society for Diseases of the Esophagus
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D'Alterio C, Avallone A, Tatangelo F, Delrio P, Pecori B, Cella L, Pelella A, D'Armiento FP, Carlomagno C, Bianco F, Silvestro L, Pacelli R, Napolitano M, Iaffaioli RV, Scala S
* A prognostic model comprising pT stage, N status, and the chemokine receptors CXCR4 and CXCR7 powerfully predicts outcome in neoadjuvant resistant rectal cancer patients (111 visite)
International Journal Of Cancer (ISSN: 0020-7136), 2014 Jul 15; 135(2): 379-390.
Impact Factor: 5.085
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Gallicchio R, Giacomobono S, Nardelli A, Pellegrino T, Simeon V, Gattozzi D, Maddalena F, Mainenti PP, Storto G
* Palliative Treatment Of Bone Metastases With Samarium-153 Edtmp At Onset Of Pain (126 visite)
Journal Of Bone And Mineral Metabolism (ISSN: 1435-5604, 0914-8779, 0914-8779linking), 2014 Jul; 32(4): 434-440.
Impact Factor: 2.46
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Orditura M, Galizia G, Di Martino N, Ancona E, Castoro C, Pacelli R, Morgillo F, Rossetti S, Gambardella V, Farella A, Laterza MM, Ruol A, Fabozzi A, Napolitano V, Iovino F, Lieto E, Fei L, Conzo G, Ciardiello F, De Vita F
* Effect of preoperative chemoradiotherapy on outcome of patients with locally advanced esophagogastric junction adenocarcinoma-a pilot study (1644 visite)
Curr Oncol Multimed Inc (ISSN: 1198-0052), 2014 Jun; 21(3): 125-133.
Impact Factor: 1.785
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Cella L, Liuzzi R, D'Avino V, Conson M, Di Biase A, Picardi M, Pugliese N, Solla R, Salvatore M, Pacelli R
* Pulmonary damage in Hodgkin's lymphoma patients treated with sequential chemo-radiotherapy: Predictors of radiation-induced lung injury (121 visite)
Acta Oncol Acta Oncologica (ISSN: 0284-186x, 1651-226x), 2014 May; 53(5): 613-619.
Impact Factor: 2.997
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Cefalo G, Massimino M, Ruggiero A, Barone G, Ridola V, Spreafico F, Potepan P, Abate ME, Mascarin M, Garrè ML, Perilongo G, Madon E, Colosimo C, Riccardi R
* Temozolomide is an active agent in children with recurrent medulloblastoma/primitive neuroectodermal tumor: An Italian multi-institutional phase II trial (143 visite)
Neuro Oncology Oxford University Press (ISSN: 1522-8517), 2014 May; 16(5): 748-753.
Impact Factor: 6.776
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Accardo A, Aloj L, Aurilio M, Morelli G, Tesauro D
* Receptor binding peptides for target-selective delivery of nanoparticles encapsulated drugs (199 visite)
Int J Nanomed (ISSN: 1176-9114, 1178-2013, 1178-2013electronic), 2014 Mar 27; 9(1): 1537-1557.
Impact Factor: 4.383
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Pedicini P, Strigari L, Benassi M, Caivano R, Fiorentino A, Nappi A, Salvatore M, Storto G
* Critical dose and toxicity index of organs at risk in radiotherapy: analyzing the calculated effects of modified dose fractionation in non-small cell lung cancer (148 visite)
Med Dosim Medical Dosimetry (ISSN: 1873-4022, 0958-3947), 2014 Mar; 39(1): 23-30.
Impact Factor: 0.76
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Formisano L, Nappi L, Rosa R, Marciano R, D'Amato C, D'Amato V, Damiano V, Raimondo L, Iommelli F, Scorziello A, Troncone G, Veneziani BM, Parsons SJ, De Placido S, Bianco R
* Epidermal growth factor-receptor activation modulates Src-dependent resistance to lapatinib in breast cancer models (142 visite)
Breast Cancer Res Biomed Central Ltd (ISSN: 1465-5411), 2014; 16(3): R45-R45.
Impact Factor: 0.635
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Perri F, Dell'Oca I, Muto P, Schiavone C, Aversa C, Fulciniti F, Solla R, Scarpati GD, Buonerba C, Di Lorenzo G, Caponigro F
* Optimal management of a patient with recurrent nasopharyngeal carcinoma (87 visite)
World Journal Of Clinical Cases (ISSN: 2307-8960), 2014; 2(7): 297-300.
Impact Factor: 0.895
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Dynkevich Y, Rother KI, Whitford I, Qureshi S, Galiveeti S, Szulc AL, Danoff A, Breen TL, Kaviani N, Shanik MH, LeRoith D, Vigneri R, Koch CA, Roth J
* Tumors, IGF-2, and Hypoglycemia: Insights From the Clinic, the Laboratory, and the Historical Archive (690 visite)
Endocrine Reviews (ISSN: 0163-769x), 2013 Dec; 34(6): 798-826.
Impact Factor: 19.358
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Pedicini P, Fiorentino A, Improta G, Nappi A, Salvatore M, Storto G
* Estimate of the accelerated proliferation by protein tyrosine phosphatase (PTEN) over expression in postoperative radiotherapy of head and neck squamous cell carcinoma (125 visite)
Clin Transl Oncol (ISSN: 1699-048x), 2013 Nov; 15(11): 919-924.
Impact Factor: 1.6
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Cella L, D'Avino V, Liuzzi R, Conson M, Doria F, Faiella A, Loffredo F, Salvatore M, Pacelli R
* Multivariate normal tissue complication probability modeling of gastrointestinal toxicity after external beam radiotherapy for localized prostate cancer (130 visite)
Radiation Oncology (ISSN: 1748-717x), 2013 Sep 23; 8(1): 221-221.
Impact Factor: 2.36
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Passaro C, Abagnale A, Libertini S, Volpe M, Botta G, Cella L, Pacelli R, Halldèn G, Gillespie D, Portella G
* Ionizing radiation enhances dl922-947-mediated cell death of anaplastic thyroid carcinoma cells (137 visite)
Endocr Relat Cancerendocrine Related Cancer (ISSN: 1351-0088), 2013 Sep 19; 20(5): 633-647.
Impact Factor: 4.907
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Acampa W, Petretta MP, Daniele S, Perrone-Filardi P, Petretta M, Cuocolo A
* Myocardial perfusion imaging after coronary revascularization: A clinical appraisal (141 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2013 Sep; 40(8): 1275-1282.
Impact Factor: 5.217
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Storto G, Gallicchio R, Pellegrino T, Nardelli A,  De Luca S, Capacchione D, Sirignano C, Pace L
* Impact of F-18-fluoride PET-CT on implementing early treatment of painful bone metastases with Sm-153 EDTMP (111 visite)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897, 0969-8051linking), 2013 May; 40(4): 518-523.
Impact Factor: 2.408
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Maurea S, Fiumara G, Pellegrino T, Zampella E, Assante R, Mainenti PP, Cuocolo A
* MIBG molecular imaging for evaluating response to chemotherapy in patients with malignant pheochromocytoma: preliminary results (106 visite)
Cancer Imaging (ISSN: 1470-7330, 1470-7330electronic, 1470-7330linking), 2013 Apr 15; 13: 155-161.
Impact Factor: 1.286
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Accardo A, Mangiapia G, Paduano L, Morelli G, Tesauro D
* Octreotide labeled aggregates containing platinum complexes as nanovectors for drug delivery (159 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Apr; 19(4): 190-197.
Impact Factor: 1.862
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D'Angelo D, Borbone E, Palmieri D, Uboldi S, Esposito F, Frapolli R, Pacelli R, D'Incalci M, Fusco A
* The impairment of the High Mobility Group A (HMGA) protein function contributes to the anticancer activity of trabectedin (121 visite)
European Journal Of Cancer (ISSN: 0959-8049), 2013 Mar; 49(5): 1142-1151.
Impact Factor: 4.819
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Cella L, Conson M, Pressello MC, Molinelli S, Schneider U, Donato V, Orecchia R, Salvatore M, Pacelli R
* Hodgkin's lymphoma emerging radiation treatment techniques: Trade-offs between late radio-induced toxicities and secondary malignant neoplasms (126 visite)
Radiat Oncol Radiation Oncology (ISSN: 1748-717x), 2013 Jan 30; 8(1): 22-22.
Impact Factor: 2.36
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Rosa R, Marciano R, Malapelle U, Formisano L, Nappi L, D'Amato C, D'Amato V, Damiano V, Marf G, Del Vecchio S, Zannetti A, Greco A, De Stefano A, Carlomagno C, Veneziani BM, Troncone G, De Placido S, Bianco R
* Sphingosine Kinase 1 Overexpression Contributes to Cetuximab Resistance in Human Colorectal Cancer Models (145 visite)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2013 Jan 1; 19(1): 138-147.
Impact Factor: 8.193
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Messori L, Scaletti F, Massai L, Cinellu MA, Gabbiani C, Vergara A, Merlino A
* The mode of action of anticancer gold-based drugs: a structural perspective (108 visite)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2013; 49(86): 10100-10102.
Impact Factor: 6.718
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Cella L, Liuzzi R, Conson M, D'Avino V, Salvatore M, Pacelli R
* Development of multivariate NTCP models for radiation-induced hypothyroidism: A comparative analysis (155 visite) (PDF 132 visite)
Radiat Oncol Radiation Oncology (ISSN: 1748-717x), 2012 Dec 27; 7(1): 224-224.
Impact Factor: 2.107
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Fonti R, Larobina M, Del Vecchio S,  de Luca S, Fabbricini R, Catalano L, Pane F, Salvatore M, Pace L
* Metabolic tumor volume assessed by 18F-FDG PET/CT for the prediction of outcome in patients with multiple myeloma (155 visite)
J Nucl Med (ISSN: 1535-5667, 0161-5505, 1535-5667electronic), 2012 Dec; 53(12): 1829-1835.
Impact Factor: 5.774
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Pedicini P, Nappi A, Strigari L, Jereczek-Fossa BA, Alterio D, Cremonesi M, Botta F, Vischioni B, Caivano R, Fiorentino A, Improta G, Storto G, Benassi M, Orecchia R, Salvatore M
* Correlation between EGFr expression and accelerated proliferation during radiotherapy of head and neck squamous cell carcinoma (100 visite)
Radiation Oncology (ISSN: 1748-717x), 2012 Sep 24; 7: 143-143.
Impact Factor: 2.107
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Elefante A, Peca C, Del Basso DCM, Russo C, Formicola F, Mariniello G, Brunetti A, Maiuri F
* Symptomatic spinal cord metastasis from cerebral oligodendroglioma (116 visite)
Neurol Sci (ISSN: 1590-1874, 1590-3478), 2012 Jun; 33(3): 609-613.
Impact Factor: 1.412
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Cella L, Conson M, Caterino M, De Rosa N, Liuzzi R, Picardi M, Grimaldi F, Solla R, Farella A, Salvatore M, Pacelli R
* Thyroid V30 predicts radiation-induced hypothyroidism in patients treated with sequential chemo-radiotherapy for Hodgkin's lymphoma (163 visite) (PDF 132 visite)
Int J Radiat Oncol Biol Phys (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2012 Apr 1; 82(5): 1802-1808.
Impact Factor: 4.524
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Cella L, Liuzzi R, Conson M, Torre G, Caterino M, De Rosa N, Picardi M, Camera L, Solla R, Farella A, Salvatore M, Pacelli R
* Dosimetric predictors of asymptomatic heart valvular dysfunction following mediastinal irradiation for Hodgkin's lymphoma (122 visite)
Radiother Oncol (ISSN: 0167-8140, 1879-0887, 1879-0887electronic), 2011 Nov; 101(2): 316-321.
Impact Factor: 5.58
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Accardo A, Morisco A, Tesauro D, Pedone C, Morelli G
* Naposomes: A new class of peptide-derivatized, target-selective multimodal nanoparticles for imaging and therapeutic applications (181 visite)
Ther Deliv (ISSN: 2041-5990), 2011 Feb; 2(2): 235-257.
Impact Factor: 0
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Strianese D, Tranfa F, Finelli M, De Renzo A, Staibano S, Schiemer R, Cardone D, Pacelli R, Perna F, Mascolo M, De Rosa G, Bonavolonta G
* Hepatitis C virus infection in ocular adnexal lymphomas (80 visite)
Arch Ophthalmol (ISSN: 1538-3601, 0003-9950), 2010 Oct; 128(10): 1295-1299.
Impact Factor: 3.516
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Orditura M, Galizia G, Napolitano V, Martinelli E, Pacelli R, Lieto E, Aurilio G, Vecchione L, Morgillo F, Catalano G, Ciardiello F, Del Genio A, Di Martino N, De Vita F
* Weekly Chemotherapy with Cisplatin and Paclitaxel and Concurrent Radiation Therapy as Preoperative Treatment in Locally Advanced Esophageal Cancer: A Phase II Study (103 visite)
Cancer Investigation (ISSN: 0735-7907), 2010 Oct; 28(8): 820-827.
Impact Factor: 2.39
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Di Lorenzo G, Imbimbo M, Leopardo D, Marciano R, Federico P, Buonerba C, Salvatore B, Marinelli A, Palmieri G. A
* A long-lasting response to sorafenib treatment in an advanced hepatocellular carcinoma patient (91 visite)
Int J Immunopathol Pharmacol (ISSN: 0394-6320), 2010 Jul; 23(3): 951-954.
Impact Factor: 2.685
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Bombardieri E, Ambrosini V, Aktolun C, Baum RP, Bishof-delaloye A, Del Vecchio S, Maffioli L, Mortelmans L, Oyen W, Pepe G, Chiti A
* In-111-pentetreotide scintigraphy: procedure guidelines for tumour imaging (165 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2010 Jul; 37(7): 1441-1448.
Impact Factor: 5.036
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Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Pizzuti LM, Lettieri A, Salvatore M
* PET/CT in cancer research: From preclinical to clinical applications (172 visite)
Contrast Media Mol Imaging (ISSN: 1555-4309, 1555-4309linking), 2010 Jul; 5(4): 190-200.
Impact Factor: 4.02
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Cella L, Liuzzi R, Magliulo M, Conson M, Camera L, Salvatore M, Pacelli R
* Radiotherapy of large target volumes in Hodgkin's lymphoma: Normal tissue sparing capability of forward IMRT versus conventional techniques (160 visite) (PDF 132 visite)
Radiat Oncol Radiation Oncology (ISSN: 1748-717x), 2010 May 11; 5(1): 33-33.
Impact Factor: 2.409
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Kelly SE, Di Benedetto A, Greco A, Howard CM, Sollars VE, Primerano DA, Valluri JV, Claudio PP
* Rapid Selection and Proliferation of CD133(+) Cells from Cancer Cell Lines: Chemotherapeutic Implications (142 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2010 Apr 8; 5(4): N/D-N/D.
Impact Factor: 4.411
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Alberobello AT, D'Esposito V, Marasco D, Doti N, Ruvo M, Bianco R, Tortora G, Esposito I, Fiory F, Miele C, Beguinot F, Formisano P
* Selective Disruption of Insulin-like Growth Factor-1 (IGF-1) Signaling via Phosphoinositide-dependent Kinase-1 Prevents the Protective Effect of IGF-1 on Human Cancer Cell Death (108 visite)
J Biol Chem Journal Of Biological Chemistry (ISSN: 0021-9258, 1083-351x), 2010 Feb 26; 285(9): 6563-6572.
Impact Factor: 5.328
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Storto G, De Renzo A, Pellegrino T, Perna F, De Falco T, Erra P, Nardelli A, Speranza A, Klain M, Rotoli B, Pace L
* Assessment of Metabolic Response to Radioimmunotherapy with (90)Y-Ibritumomab Tiuxetan in Patients with Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma (112 visite)
Radiology (ISSN: 0033-8419, 1527-1315, 0033-8419linking), 2010 Jan; 254(1): 245-252.
Impact Factor: 6.069
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De Cicco L, Cella L, Liuzzi R, Solla R, Farella A, Punzo G, Tranfa F, Strianese D, Conson M, Bonavolontà G, Salvatore M, Pacelli R
* Radiation therapy in primary orbital lymphoma: A single institution retrospective analysis (145 visite)
Radiat Oncol Radiation Oncology (ISSN: 1748-717x), 2009 Dec 7; 4(1): 60-60.
Impact Factor: 2.36
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Peca C, Pacelli R, Elefante A, Del Basso De Caro ML, Vergara P, Mariniello G, Giamundo A, Maiuri F
* Early clinical and neuroradiological worsening after radiotherapy and concomitant temozolomide in patients with glioblastoma: Tumour progression or radionecrosis? (118 visite)
Clin Neurol Neurosurg (ISSN: 0303-8467), 2009 May; 111(4): 331-334.
Impact Factor: 1.303
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Carlomagno C, Farella A, Bucci L, D'Armiento FP, Pesce G, Pepe S, Cannella L, Pacelli R, De Stefano A, Solla R, D'Armiento MR, De Placido S
* Neo-adjuvant treatment of rectal cancer with capecitabine and oxaliplatin in combination with radiotherapy: A phase II study (120 visite)
Annals Of Oncology (ISSN: 0923-7534), 2009 May; 20(5): 906-912.
Impact Factor: 5.647
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Storto G, Nicolai E, Salvatore M
* [18F]FDG-PET-CT for early monitoring of tumor response: When and why (145 visite)
Q J Nucl Med Mol Imaging (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2009 Apr; 53(2): 167-180.
Impact Factor: 1.724
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Garzia L, Andolfo I, Cusanelli E, Marino N, Petrosino G, De Martino D, Esposito V, Galeone A, Navas L, Esposito S, Gargiulo S, Fattet S, Donofrio V, Cinalli G, Brunetti A, Del Vecchio L, Northcott PA, Delattre O, Taylor MD, Iolascon A, Zollo M
* MicroRNA-199b-5p Impairs Cancer Stem Cells through Negative Regulation of HES1 in Medulloblastoma (149 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2009 Mar 24; 4(3): e4998-e4998.
Impact Factor: 4.351
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De Bonis S, Rendina D, Vargas G, Minno DD, Piedimonte V, Gallotta G, Postiglione A
* Predictors of In-Hospital and Long-Term Clinical Outcome in Elderly Patients with Massive Pulmonary Embolism Receiving Thrombolytic Therapy (79 visite)
J Am Geriatr Soc (ISSN: 0002-8614), 2008 Dec; 56(12): 2273-2277.
Impact Factor: 3.805
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Picardi M, De Renzo A, Pane F, Nicolai E, Pacelli R, Salvatore M, Rotoli B
* Randomized comparison of consolidation radiation versus observation in bulky Hodgkin's lymphoma with post-chemotherapy negative positron emission tomography scans (132 visite)
Leuk Lymphoma (ISSN: 1042-8194, 1026-8022linking), 2007 Sep; 48(9): 1721-1727.
Impact Factor: 1.512
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Del Vecchio S, Zannetti A, Fonti R, Pace L, Salvatore M
* Nuclear imaging in cancer theranostics (194 visite)
Q J Nucl Med Mol Imaging (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 152-163.
Impact Factor: 1.724
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Catalano L, Del Vecchio S, Petruzziello F, Fonti R, Salvatore B, Martorelli C, Califano C, Caparrotti G, Segreto S, Pace L, Rotoli B
* Sestamibi and FDG-PET scans to support diagnosis of jaw osteonecrosis (138 visite)
Ann Hematol (ISSN: 0939-5555, 0939-5555linking), 2007 Jun; 86(6): 415-423.
Impact Factor: 2.342
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Gustavsson T, Sarkar N, Banyasz A, Markovitsi D, Improta R
* Solvent effects on the steady-state absorption and fluorescence spectra of uracil, thymine and 5-fluorouracil (91 visite)
Photochem Photobiol (ISSN: 0031-8655), 2007 May; 83(3): 595-599.
Impact Factor: 2.172
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Palmieri G, Marino M, Salvatore M, Budillon A, Meo G, Caraglia M, Montella L
* Cetuximab is an active treatment of metastatic and chemorefractory thymoma (92 visite)
Frontiers In Bioscience (ISSN: 1093-9946, 1093-4715), 2007 Jan 1; 12(2): 757-761.
Impact Factor: 2.989
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Santoro F, Barone V, Gustavsson T, Improta R
* Solvent effect on the singlet excited-state lifetimes of nucleic acid bases: A computational study of 5-fluorouracil and uracil in acetonitrile and water (87 visite)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2006 Dec 20; 128(50): 16312-16322.
Impact Factor: 7.696
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Gustavsson T, Sarkar N, Lazzarotto E, Markovitsi D, Barone V, Improta R
* Solvent effect on the singlet excited-state dynamics of 5-fluorouracil in acetonitrile as compared with water (128 visite)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2006 Jul 6; 110(26): 12843-12847.
Impact Factor: 4.115
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Iommelli F, Zannetti A, Pepe S, Sabbatino F, Laus G, Ghidelli L, Solla R, Scala S, Del Vecchio S, Salvatore M, Pacelli R
* Inhibition of NF-kappa B activity potentiates ionizing radiation and cisplatin induced cell killing of anaplastic thyroid carcinoma cells (119 visite)
Meetingproceedings Of The American Association For Cancer Research Annual (ISSN: 0197-016x), 2006 Apr; 47: N/D-N/D.
Impact Factor: 0
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Cuocolo A, Acampa W, Varrone A, Salvatore M
* Highlights of the Annual Congress of the European Association of Nuclear Medicine, Istanbul, 2005: The incremental value of nuclear medicine for patient management and care (216 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Mar; 33(3): 360-381.
Impact Factor: 4.041
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Gustavsson T, Banyasz A, Lazzarotto E, Markovitsi D, Scalmani G, Frisch MJ, Barone V, Improta R
* Singlet excited-state behavior of uracil and thymine in aqueous solution: A combined experimental and computational study of 11 uracil derivatives (137 visite)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2006 Jan 18; 128(2): 607-619.
Impact Factor: 7.696
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Tauchmanovà L, Pensabene M, Capuano I, Spagnoletti I, Zeppa P, Del Vecchio S, Mainenti PP, De Rosa G, Colao A, Contegiacomo A
* Poorly differentiated small cell neuroendocrine carcinoma localized in three different endocrine glands: Response to chemotherapy and octreotide LAR (110 visite)
J Endocrinol Invest (ISSN: 0391-4097, 1720-8386electronic), 2005 Apr; 28(4): 371-378.
Impact Factor: 1.496
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d'Alesio V, Pacelli R, Durante M, Canale Cama G, Cella L, Gialanella G, Grossi G, Pugliese M, Punzo G, Sardi I, Scampoli P, Solla R, Salvatore M
* Lymph nodes in the irradiated field influence the yield of radiation-induced chromosomal aberrations in lymphocytes from breast cancer patients (131 visite)
Int J Radiat Oncol Biol Phys (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2003 Nov 1; 57(3): 732-738.
Impact Factor: 4.285
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Mainenti PP, Romano L, Contegiacomo A, Romano M, Casella V, Cuccuru A, Insabato L, Salvatore M
* Rare diffuse peritoneal malignant neoplasms: CT findings in two cases (109 visite)
Abdom Imaging (ISSN: 0942-8925, 1432-0509), 2003 Nov; 28(6): 827-830.
Impact Factor: 0.996
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Portella G, Pacelli R, Libertini S, Cella L, Vecchio G, Salvatore M, Fusco A
* ONYX-015 Enhances Radiation-Induced Death of Human Anaplastic Thyroid Carcinoma Cells (144 visite)
J Clin Endocrinol Metab Journal Of Clinical Endocrinology And Metabolism (ISSN: 0021-972x), 2003 Oct 1; 88(10): 5027-5032.
Impact Factor: 5.873
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Del Vecchio S, Zannetti A, Aloj L, Caracò C, Ciarmiello A, Salvatore M
* Inhibition of early Tc-99m-MIBI uptake by Bcl-2 anti-apoptotic protein overexpression in untreated breast carcinoma (143 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2003 Jun; 30(6): 879-887.
Impact Factor: 3.324
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Tauchmanova L, De Rosa G, Serio B, Fazioli F, Mainolfi C, Lombardi G, Colao A, Salvatore M, Rotoli B, Selleri C
* Avascular necrosis in long-term survivors after allogeneic or autologous stem cell transplantation: A single center experience and a review (131 visite)
Cancer (ISSN: 0008-543x), 2003 May 15; 97(10): 2453-2461.
Impact Factor: 2.045
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Romano M, Giojelli A, Tamburrini O, Salvatore M
* Chemoembolization for hepatocellular carcinoma: Effect of intraarterial lidocaine in peri- and post-procedural pain and hospitalization (100 visite)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2003 Apr; 105(4): 350-355.
Impact Factor: 1.368
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Lomax AJ, Cella L, Weber D, Kurtz JM, Miralbell R
* Potential role of IMRT and protons in the treatment of the breast and regional nodes (103 visite)
Int J Rad Oncol Biol Phys, 2003 Mar 1; 48(3Supplement): 785-792.
Impact Factor: 0.155
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Del Vecchio S, Zannetti A, Aloj L, Salvatore M
* MIBI as prognostic factor in breast cancer (96 visite)
Q J Nucl Med (ISSN: 1124-3937, 1125-0135), 2003 Mar; 47(1): 46-50.
Impact Factor: 2.222
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Lomax AJ, Cella L, Weber D, Kurtz JM, Miralbell R
* Potential role of intensity-modulated photons and protons in the treatment of the breast and regional nodes (84 visite)
Int J Radiat Oncol Biol Phys (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2003; 55(3): 785-792.
Impact Factor: 4.285
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Cama G, Vassallo P, Alberti D, Cante D, Solla R, Punzo G, Cella L, Pacelli R
* Primary non-Hodgkin's lymphoma of the lacrimal sac: A case report (96 visite)
Tumori (ISSN: 0300-8916, 0300-8916print), 2002 Nov; 88(6): 530-531.
Impact Factor: 0.267
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Cante D, Solla R, Manzo R, Chianese E, Punzo G, Cella L, Vassallo P, Morra A, Alterio D, Alberti D, Pacelli R, Canale Cama G
* A case report of a primary NHL of the lacrimal sac (126 visite)
Tumori (ISSN: 0300-8916, 0300-8916print), 2001 Jul; 87(4): 530-531.
Impact Factor: 0.49
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Gridelli C, Manzione L, Perrone F, Veltri E, Cioffi R, Caprio MG, Frontini L, Rossi A, Barletta E, Barzelloni ML, Bilancia D, Gallo C
* Carboplatin plus paclitaxel in extensive small cell lung cancer: a multicentre phase 2 study (90 visite) (PDF 128 visite)
Br J Cancer (ISSN: 0007-0920print, 0007-0920linking), 2001 Jan 5; 84(1): 38-41.
Impact Factor: 3.942
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Cella L, Lomax A, Miralbell R
* New techniques in hadrontherapy: Intensity modulated proton beams (83 visite)
Phys Med (ISSN: 1120-1797, 1120-1797linking), 2001; 17(SUPPL.1): 100-102.
Impact Factor: 0.556
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Cella L, Lomax A, Miralbell R
* Potential role of intensity modulated proton beams in prostate cancer radiotherapy (86 visite)
Int J Radiat Oncol Biol Phys (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2001; 49(1): 217-223.
Impact Factor: 3.327
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Herscher LL, Cook JA, Pacelli R, Pass HI, Russo A, Mitchell JB
Principles of chemoradiation: Theoretical and practical considerations (104 visite)
Oncology (ISSN: 0890-9091), 1999 Oct; 13(10SUPPL.5): 11-22.
Impact Factor: 0.933
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Wink DA, Cook JA, Christodoulou D, Krishna MC, Pacelli R, Kim S, DeGraff W, Gamson J, Vodovotz Y, Russo A, Mitchell JB
Nitric oxide and some nitric oxide donor compounds enhance the cytotoxicity of cisplatin (92 visite)
Nitric Oxide Biology And Chemistry (ISSN: 1089-8603), 1997 Feb; 1(1): 88-94.
Impact Factor: 2.151
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Brunetti A, Alfano B, Soricelli A, Tedeschi E, Mainolfi C, Covelli EM, Aloj L, Panico M, Bazzicalupo L, Salvatore M
Functional characterization of brain tumors: An overview of the potential clinical value (159 visite) (PDF 133 visite)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1996 Sep; 23(6): 699-715.
Impact Factor: 1.042
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MAUREA S, LASTORIA S, CARACO C, INDOLFI P, CASALE F, DITULLIO M, SALVATORE M
IODINE-131-MIBG IMAGING TO MONITOR CHEMOTHERAPY RESPONSE IN ADVANCED NEUROBLASTOMA - COMPARISON WITH LABORATORY ANALYSIS (129 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1994 Sep; 35(9): 1429-1435.
Impact Factor: 3.491
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Iaffaioli RV, Frasci G, Facchini G, Pagliarulo C, Pacelli R, Scala S, Espinosa A, Bianco AR
Alpha 2b interferon (IFN) by intraperitoneal administration via temporary catheter in ovarian cancer. Preliminary data (69 visite)
Eur J Gynaecol Oncol (ISSN: 0392-2936), 1991; 12(1): 69-75.
Impact Factor: 0.397
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Alfano B, Coucourde F, Malgieri F, Ragozzino A
PET/CT and radiotherapy (138 visite)
Q J Nucl Med Mol Imaging, 1980 Oct; 50(1): 4-14.
Impact Factor: 0
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105 Records (97 escludendo Abstract e Conferenze).
Impact factor totale: 350.118 (329.942 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 374.658 (352.675 escludendo Abstract e Conferenze).







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