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The EEE project (111 visite)

Aloj L, Aurilio M, Rinaldi V, D'Ambrosio L, Tesauro D, Peitl PK, Maina T, Mansi R, Von Guggenberg E, Joosten L, Sosabowski JK, Breeman WA, De Blois E, Koelewijn S, Melis M, Waser B, Beetschen K, Reubi JC, De Jong M

Proc Int Cosm Ray Conf Icrc Universidad Nacional Autonoma De Mexico, 2007; 5(HEPART2): 977-980.



Tipo di articolo: Journal Article,

Impact factor: 0, Impact factor a 5 anni: 0

Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84899507056&partnerID=40&md5=1a5c63137254d5091ee5597590b626fe

Parole chiave: Charged Particles, Compensation (personnel), Societies And Institutions, Telescopes, European Organization For Nuclear Researches, Experimental Apparatus, Extensive Air Showers, High School, Multi-Gap Resistive Plate Chambers, Muon Telescope, Temporal Resolution, Tracking Detectors, Cosmic Rays, Cholecystokinin, Dota, Gastrin, Tumour, 10 Tetraazacyclododecane 1, 10 Tetraacetic Acid, Cholecystokinin B Receptor, Gastrin Receptor, Indium 111, Animal Cell, Autoradiography, Binding Affinity, Binding Site, Cancer Tissue, Comparative Study, Controlled Study, Dissociation Constant, Human, Human Cell, Human Tissue, In Vitro Study, Nonhuman, Protein Binding, Protein Localization, Protein Stability, Protein Transport, Receptor Affinity, Receptor Binding, Thyroid Medullary Carcinoma, Tissue Section, Amino Acid Sequence, Cell Line, Cooperative Behavior, Heterocyclic Compounds, 1-Ring, Indium Radioisotopes, Inhibitory Concentration 50, Molecular Sequence Data, Peptides,

Affiliazioni:

*** IBB - CNR ***
INFN, Department of Physics, University of Bologna, Italy
Centro Studi E Ricerche E. Fermi, Museo Storico della Fisica, Rome, Italy
INFN, Laboratori Nazionali di Frascati, Italy
World Laboratory, Lausanne, Switzerland
CERN Geneva, Switzerland
AF Medicina Nucleare, Istituto Nazionale Tumori, Fondazione G. Pascale, Via M. Semmola, 80131 Naples, Italy
CIRPeB, Università Federico II, Naples, Italy
Department of Nuclear Medicine, University Medical Centre Ljubljana, Ljubljana, Slovenia
Molecular Radiopharmacy, Institute of Radioisotopes-Radiodiagnostic Products, National Center for Scientific Research Demokritos, Athens, Greece
Centre for Molecular Oncology and Imaging, Institute of Cancer, Barts and the London Queen Mary's School of Medicine and Dentistry, London, United Kingdom
University of Berne, Berne, Switzerland
CIRPeB, Universit Federico II, Naples, Italy



Riferimenti:

Progetto, La scienza nelle scuole (2005) EEE Extreme Energy Events, , http://www.centrofermi.it/eee, Antonino Zichichi, Italian Physical Societ

Antolini, R., The EEE project (2005) 29th ICRC Proceedings, 8, p. 279. , Pune

Akindinov, A.N., (2000) Nucl. Instr. and Meth., A456, p. 16

Antolini, R., (2007) Nuclear Physics, B165, p. 333. , Proc. Suppl

An, S., (2007) Proceedings of the VCI2007 Conference, , Vienna, to be published on Nucl. Instr. and Meth. A

Abbrescia, M., Multigap resistive plate chambers for EAS study in the EEE project (2007) 30th ICRC, , these Proceedings

Anghinolfi, A., (2004) Nucl. Instr. and Meth., A533, p. 183

Abbrescia, M., (2007) Proceedings of the RICAP07 Conference, , Rome, to be published on Nucl. Instr. and Meth. A

Reubi, J.C., Peptide receptors as molecular targets for cancer diagnosis and therapy (2003) Endocrine Reviews, 24 (4), pp. 389-427. , DOI 10.1210/er.2002-000

Reubi, J.C., Schaer, J.-C., Waser, B., Cholecystokinin (CCK)-A and CCK-B/gastrin receptors in human tumors (1997) Cancer Research, 57 (7), pp. 1377-1386

Roman, S., Mehta, P., Sosa, J.A., Medullary thyroid cancer: Early detection and novel treatments (2009) Curr Opin Oncol, 21, pp. 5-10

Behe, M., Becker, W., Gotthardt, M., Angerstein, C., Behr, T.M., Improved kinetic stability of DTPA-DGlu as compared with conventional monofunctional DTPA in chelating indium and yttrium: Preclinical and initial clinical evaluation of radiometal labelled minigastrin derivatives (2003) European Journal of Nuclear Medicine and Molecular Imaging, 30 (8), pp. 1140-1146. , DOI 10.1007/s00259-003-1178-1

Behr, T.M., Behe, M., Becker, W., Diagnostic applications of radiolabeled peptides in nuclear endocrinology (1999) Quarterly Journal of Nuclear Medicine, 43 (3), pp. 268-280

Good, S., Walter, M.A., Waser, B., Wang, X., Müller-Brand, J., Béhé, M.P., Macrocyclic chelator-coupled gastrin-based radiopharmaceuticals for targeting of gastrin receptor-expressing tumours (2008) Eur J Nucl Med Mol Imaging, 35, pp. 1868-1877. , doi:10.1007/s00259-008-0803-4

Aloj, L., Caraco, C., Panico, M., Zannetti, A., Del Vecchio, S., Tesauro, D., De Luca, S., Salvatore, M., In vitro and in vivo evaluation of 111In-DTPAGlu-G-CCK8 for cholecystokinin-b receptor imaging (2004) Journal of Nuclear Medicine, 45 (3), pp. 485-494. , http://jnm.snmjournals.org/cgi/reprint/45/3/485

Reubi, J.C., Waser, B., Schaer, J.C., Laederach, U., Erion, J., Srinivasan, A., Schmidt, M.A., Bugaj, J.E., Unsulfated DTPA- and DOTA-CCK analogs as specific high-affinity ligands for CCK-B receptor-expressing human and rat tissues in vitro and in vivo (1998) European Journal of Nuclear Medicine, 25 (5), pp. 481-490. , DOI 10.1007/s002590050247

Von Guggenberg, E., Sallegger, W., Helbok, A., Ocak, M., King, R., Mather, S.J., Cyclic minigastrin analogues for gastrin receptor scintigraphy with technetium-99m: Preclinical evaluation (2009) J Med Chem, 52, pp. 4786-4793. , doi:10.1021/jm900400w

Roosenburg, S., Laverman, P., Joosten, L., Eek, A., Oyen, W.J., De Jong, M., Stabilized (111)In-labeled sCCK8 analogues for targeting CCK2-receptor positive tumors: Synthesis and evaluation (2010) Bioconjug Chem, 21, pp. 663-670. , doi:10.1021/bc900465y

Mather, S.J., McKenzie, A.J., Sosabowski, J.K., Morris, T.M., Ellison, D., Watson, S.A., Selection of radiolabeled gastrin analogs for peptide receptor-targeted radionuclide therapy (2007) Journal of Nuclear Medicine, 48 (4), pp. 615-622. , http://jnm.snmjournals.org/cgi/reprint/48/4/615, DOI 10.2967/jnumed.106.037085

Sosabowski, J.K., Matzow, T., Foster, J.M., Finucane, C., Ellison, D., Watson, S.A., Targeting of CCK-2 receptor-expressing tumors using a radiolabeled divalent gastrin peptide (2009) J Nucl Med, 50, pp. 2082-2089. , doi:10.2967/jnumed.109.064808

Nock, B.A., Maina, T., Behe, M., Nikolopoulou, A., Gotthardt, M., Schmitt, J.S., Behr, T.M., Macke, H.R., CCK-2/gastrin receptor-targeted tumor imaging with 99mTc- labeled minigastrin analogs (2005) Journal of Nuclear Medicine, 46 (10), pp. 1727-1736

Fröberg, A.C., De Jong, M., Nock, B.A., Breeman, W.A., Erion, J.L., Maina, T., Comparison of three radiolabelled peptide analogues for CCK-2 receptor scintigraphy in medullary thyroid carcinoma (2009) Eur J Nucl Med Mol Imaging, 36, pp. 1265-1272. , doi:10.1007/s00259-009-1098-9

Béhé, M., Behr, T.M., Cholecystokinin-B (CCK-B)/gastrin receptor targeting peptides for staging and therapy of medullary thyroid cancer and other CCK-B receptor expressing malignancies (2002) Biopolymers, 66, pp. 399-418. , doi:10.1002/bip.10356

Behe, M., Kluge, G., Becker, W., Gotthardt, M., Behr, T.M., Use of polyglutamic acids to reduce uptake of radiometal-labeled minigastrin in the kidneys (2005) Journal of Nuclear Medicine, 46 (6), pp. 1012-1015

Laverman, P., Roosenburg, S., Gotthardt, M., Park, J., Oyen, W.J., De Jong, M., Targeting of a CCK 2) receptor splice variant with 111)In-labelled cholecystokinin-8 (CCK8) and (111)In-labelled minigastrin (2008) Eur J Nucl Med Mol Imaging, 35, pp. 386-392. , doi:10.1007/s00259-007-0604-1

Ocak, M., Helbok, A., Rangger, C., Peitl, P.K., Nock, B., Morelli, G., Comparison of biological stability and metabolism of CCK2-receptor targeting peptides, a collaborative project under COST BM0607 (2011) Eur J Nucl Med Mol Imaging, , in press

Sosabowski, J.K., Finucane, C., Foster, J.M., Ellison, D., Burnet, J., Laverman, P., (2011) Comparison of 111In-Labelled CCK2-Receptor Targeting Peptides using NanoSPECT/CT imaging, , Submitted for publication

Giragossian, C., Mierke, D.F., Intermolecular interactions between cholecystokinin-8 and the third extracellular loop of the cholecystokinin-2 receptor (2002) Biochemistry, 41 (14), pp. 4560-4566. , DOI 10.1021/bi0160009

D'Andrea, L.D., Testa, I., Panico, M., Di Stasi, R., Caracó, C., Tarallo, L., In vivo and in vitro characterization of CCK8 bearing a histidine-based chelator labeled with 99mTc-tricarbonyl (2008) Biopolymers, 90, pp. 707-712. , doi:10.1002/bip.21041

Tornesello, A.L., Aurilio, M., Accardo, A., Tarallo, L., Barbieri, A., Arra, C., Gastrin and cholecystokinin peptide-based radiopharmaceuticals: An in vivo and in vitro comparison (2011) J Pept Sci, 17, pp. 405-412. , doi:10.1002/psc.1327

Marsouvanidis, P.J., Tatsi, A., Nock, B.A., Krenning, E.P., Maina, T., De Jong, M., [111In] Sargastrin, a Gastrin I-based radioligand targeting CCK2-R-positive tumors in vivo (2009) Eur J Nucl Med Mol Imaging, 36, pp. S259

Kolenc-Peitl, P., Mansi, R., Tamma, M.L., Gmeiner-Stopar, T., Sollner-Dolenc, M., Waser, B., Highly improved metabolic stability and pharmacokinetics of indium-111-DOTA-gastrin conjugates for targeting of the gastrin receptor (2011) J Med Chem, , In press

Reubi, J. C., Peptide receptors as molecular targets for cancer diagnosis and therapy (2003) Endocrine Reviews, 24 (4), pp. 389-427. , DOI 10. 1210/er. 2002-000

Reubi, J. C., Schaer, J. -C., Waser, B., Cholecystokinin (CCK) -A and CCK-B/gastrin receptors in human tumors (1997) Cancer Research, 57 (7), pp. 1377-1386

Behr, T. M., Behe, M., Becker, W., Diagnostic applications of radiolabeled peptides in nuclear endocrinology (1999) Quarterly Journal of Nuclear Medicine, 43 (3), pp. 268-280

Reubi, J. C., Waser, B., Schaer, J. C., Laederach, U., Erion, J., Srinivasan, A., Schmidt, M. A., Bugaj, J. E., Unsulfated DTPA- and DOTA-CCK analogs as specific high-affinity ligands for CCK-B receptor-expressing human and rat tissues in vitro and in vivo (1998) European Journal of Nuclear Medicine, 25 (5), pp. 481-490. , DOI 10. 1007/s002590050247

Mather, S. J., McKenzie, A. J., Sosabowski, J. K., Morris, T. M., Ellison, D., Watson, S. A., Selection of radiolabeled gastrin analogs for peptide receptor-targeted radionuclide therapy (2007) Journal of Nuclear Medicine, 48 (4), pp. 615-622. , http: //jnm. snmjournals. org/cgi/reprint/48/4/615, DOI 10. 2967/jnumed. 106. 037085

Nock, B. A., Maina, T., Behe, M., Nikolopoulou, A., Gotthardt, M., Schmitt, J. S., Behr, T. M., Macke, H. R., CCK-2/gastrin receptor-targeted tumor imaging with 99mTc- labeled minigastrin analogs (2005) Journal of Nuclear Medicine, 46 (10), pp. 1727-1736

Fr berg, A. C., De Jong, M., Nock, B. A., Breeman, W. A., Erion, J. L., Maina, T., Comparison of three radiolabelled peptide analogues for CCK-2 receptor scintigraphy in medullary thyroid carcinoma (2009) Eur J Nucl Med Mol Imaging, 36, pp. 1265-1272. , doi: 10. 1007/s00259-009-1098-9

B h, M., Behr, T. M., Cholecystokinin-B (CCK-B) /gastrin receptor targeting peptides for staging and therapy of medullary thyroid cancer and other CCK-B receptor expressing malignancies (2002) Biopolymers, 66, pp. 399-418. , doi: 10. 1002/bip. 10356

Sosabowski, J. K., Finucane, C., Foster, J. M., Ellison, D., Burnet, J., Laverman, P., (2011) Comparison of 111In-Labelled CCK2-Receptor Targeting Peptides using NanoSPECT/CT imaging, , Submitted for publication

D'Andrea, L. D., Testa, I., Panico, M., Di Stasi, R., Carac, C., Tarallo, L., In vivo and in vitro characterization of CCK8 bearing a histidine-based chelator labeled with 99mTc-tricarbonyl (2008) Biopolymers, 90, pp. 707-712. , doi: 10. 1002/bip. 21041

Tornesello, A. L., Aurilio, M., Accardo, A., Tarallo, L., Barbieri, A., Arra, C., Gastrin and cholecystokinin peptide-based radiopharmaceuticals: An in vivo and in vitro comparison (2011) J Pept Sci, 17, pp. 405-412. , doi: 10. 1002/psc. 1327

Marsouvanidis, P. J., Tatsi, A., Nock, B. A., Krenning, E. P., Maina, T., De Jong, M., [111In] Sargastrin, a Gastrin I-based radioligand targeting CCK2-R-positive tumors in vivo (2009) Eur J Nucl Med Mol Imaging, 36, pp. S259



The EEE (Extreme Energy Events) Project, conceived many years ago by its leader Antonino Zichichi [1], aims to study high-energy extensive air showers through the detection of the shower muon component by means of a network of tracking detectors, namely telescopes, installed in Italian High Schools. The Project is supported by the "Ministero dell'Istruzione, Universit̃A e Ricerca (MIUR)", "Museo Storico della Fisica e Centro Studi e Ricerche E. Fermi", "Istituto Nazionale di Fisica Nucleare (INFN)" and the European Organization for Nuclear Research (CERN). The single tracking telescope for a school is composed by 3 large (∼ 2 m2 each) Multi-gap Resistive Plate Chambers (MRPC). Using a very high precision particle detector based on MRPCs allows a very high accuracy direction reconstruction for energetic showers, together with a very good temporal resolution. In its first phase the telescopes are going to be installed in 23 High Schools located in seven pilot towns all over Italy. In the near future, as soon as new fundings will be provided, the network will be upgraded adding new High Schools and towns. The first muon telescopes have been installed in two schools nearby Rome and in one school nearby Bologna, and are successfully running. By the end of the year 2007, other telescopes will be installed. Here we present the experimental apparatus and its tasks.
Nessun risultato.
Nessun risultato.

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Pulcrano M, Camera L, Pagano L, Del Vecchio S, Ferone D, Bodei L, Murgia A, Pace L, Storto G, Paganelli G, Colao A, Salvatore M, Lombardi G, Biondi B
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Saviano M, De Luca S, Morelli G, Tesauro D, Pedone C
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D'Andrea LD, Testa I, Panico M, Di Stasi R, Carac C, Tarallo L, Arra C, Barbieri A, Romanelli A, Aloj L
* In vivo and in vitro characterization of CCK8 bearing a histidine-based chelator labeled with Tc-99m-tricarbonyl (188 visite)
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De Luca S, De Capua A, Saviano M, Della Moglie R, Aloj L, Tarallo L, Pedone C, Morelli G
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Vaccaro M, Accardo A, D'Errico G, Schillen K, Radulescu A, Tesauro D, Morelli G, Paduano L
* Peptides and gd complexes containing colloidal assemblies as tumor-specific contrast agents in MRI: Physicochemical characterization (128 visite)
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Tesauro D, Accardo A, Gianolio E, Paduano L, Teixeira J, Schillén K, Aime S, Morelli G
* Peptide derivatized lamellar aggregates as target-specific MRI contrast agents (145 visite)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 25; 8(8): 950-955.
Impact Factor: 3.446
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Agostini S, Bolzati C, Didonè E, Cavazza-Ceccato M, Refosco F, Aloj L, Arra C, Aurilio M, Tornesello AL, Tesauro D, Morelli G
* The (Tc(N)(PNP))2+ metal fragment labeled cholecystokinin-8 (CCK8) peptide for CCK-2 receptors imaging: In vitro and in vivo studies (148 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2007 Apr; 13(4): 211-219.
Impact Factor: 1.768
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Accardo A, Tesauro D, Morelli G, Gianolio E, Aime S, Vaccaro M, Mangiapia G, Paduano L, Schillén K
* High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI (140 visite)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2007 Feb; 12(2): 267-276.
Impact Factor: 3.325
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De Luca S, Saviano M, Della Moglie R, Digilio G, Bracco C, Aloj L, Tarallo L, Pedone C, Morelli G
* Conformationally constrained CCK8 analogues obtained from a rationally designed peptide library as ligands for cholecystokinin type B receptor (115 visite)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2006 Sep; 1(9): 997-1006.
Impact Factor: 3.046
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De Luca S, Saviano M, Lassiani L, Yannakopoulou K, Stefanidou P, Aloj L, Morelli G, Varnavas A
* Anthranilic acid based CCK1 receptor antagonists and CCK-8 have a common step in their "receptor desmodynamic processes" (148 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Apr 20; 49(8): 2456-2462.
Impact Factor: 5.115
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Cuocolo A, Acampa W, Varrone A, Salvatore M
* Highlights of the Annual Congress of the European Association of Nuclear Medicine, Istanbul, 2005: The incremental value of nuclear medicine for patient management and care (216 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Mar; 33(3): 360-381.
Impact Factor: 4.041
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De Luca S, Sanseverino M, Zocchi I, Pedone C, Morelli G, Ragone R
* Receptor fragment approach to the binding between CCK8 peptide and cholecystokinin receptors: A fluorescence study on type B receptor fragment CCKB-R (352-379) (106 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2005 Mar; 77(4): 205-211.
Impact Factor: 2.545
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De Luca S, Morelli G
* Synthesis and characterization of a sulfated and a non-sulfated cyclic CCK8 analogue functionalized with a chelating group for metal labelling (99 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2004 May; 10(5): 265-273.
Impact Factor: 1.652
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Accardo A, Tesauro D, Roscigno P, Gianolio E, Paduano L, D'Errico G, Pedone C, Morelli G
* Physicochemical Properties of Mixed Micellar Aggregates Containing CCK Peptides and Gd Complexes Designed as Tumor Specific Contrast Agents in MRI (136 visite)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2004 Mar 17; 126(10): 3097-3107.
Impact Factor: 6.903
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Aloj L, Caracò C, Panico M, Zannetti A, Del Vecchio S, Tesauro D, De Luca S, Arra C, Pedone C, Morelli G, Salvatore M
* In vitro and in vivo evaluation of In-111-DTPAGlu-G-CCK8 for cholecystokinin-B receptor imaging (169 visite)
J Nucl Med (ISSN: 1535-5667, 0161-5505, 1535-5667electronic), 2004 Mar; 45(3): 485-494.
Impact Factor: 5.362
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Aloj L, Panico M, Caraco C, Del Vecchio S, Arra C, Affuso A, Accardo A, Mansi R, Tesauro D, De Luca S, Pedone C, Visentin R, Mazzi U, Morelli G, Salvatore M
* In vitro and in vivo characterization of Indium-111 and Technetium-99m labeled CCK-8 derivatives for CCK-B receptor imaging (114 visite)
Cancer Biotherapy And Radiopharmaceuticals (ISSN: 1084-9785, 1084-4978), 2004 Feb; 19(1): 93-98.
Impact Factor: 1.091
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De Luca S, Ragone R, Bracco C, Digilio G, Aloj L, Tesauro D, Saviano M, Pedone C, Morelli G
* A cyclic CCK8 analogue selective for the cholecystokinin type A receptor: design, synthesis, NMR structure and binding measurements (128 visite)
Chembiochem (ISSN: 1439-7633, 1439-4227, 1439-7633electronic), 2003 Nov 7; 4(11): 1176-1187.
Impact Factor: 3.992
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De Luca S, Ragone R, Bracco C, Digilio G, Tesauro D, Saviano M, Pedone C, Morelli G
* The role of segment 32-47 of cholecystokinin receptor type A in CCK8 binding: Synthesis, nuclear magnetic resonance, circular dichroism and fluorescence studies (108 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2003 Mar; 9(3): 156-169.
Impact Factor: 1.377
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Morelli G, De Luca S, Tesauro D, Saviano M, Pedone C, Dolmella A, Visentin R, Mazzi U
* CCK8 peptide derivatized with diphenylphosphine for rhenium labelling: Synthesis and molecular mechanics calculations (100 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2002 Jul; 8(7): 373-381.
Impact Factor: 1.691
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Aloj L, Panico M, Caracó C, Zannetti A, Del Vecchio S, Di Nuzzo C, Arra C, Morelli G, Tesauro D, De Luca S, Pedone C, Salvatore M
* Radiolabeling approaches for cholecystokinin B receptor imaging (147 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2002; 66(6): 370-380.
Impact Factor: 2.372
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De Luca S, Tesauro D, Di Lello P, Fattorusso R, Saviano M, Pedone C, Morelli G
* Synthesis and solution characterization of a porphyrin-CCK8 conjugate (117 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2001 Jul; 7(7): 386-394.
Impact Factor: 1.451
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Ragone R, De Luca S, Tesauro D, Pedone C, Morelli G
Fluorescence studies on the binding between 1-47 fragment of cholecystokinin receptor CCKA-R(1-47) and nonsulfated cholecystokinin octapeptide CCK8 (123 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2000; 56(1): 47-53.
Impact Factor: 2.405
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Ferrara LA, Marotta T, Mainenti G, Fasano ML, Mancini M, Borrelli R, Soro S
Blood Pressure An Pre-High School Children (68 visite)
4th European Meeting On Hypertension Milan, 1989; N/D: 663-663.
Impact Factor: 0
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43 Records (42 escludendo Abstract e Conferenze).
Impact factor totale: 113.037 (113.037 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 121.994 (121.994 escludendo Abstract e Conferenze).







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