A straightforward synthetic access to symmetrical glycosyl disulfides and biological evaluation thereof(146 visite) Adinolfi M, Capasso D, Di Gaetano S, Iadonisi A, Leone L, Pastore A
*** IBB - CNR *** Dipartimento di Chimica Organica e Biochimica, Università Federico II di Napoli, via Cinthia 4, I-80126 Naples, Italy Facoltà di Scienze Biotecnologiche, Università di Napoli Federico II, via Mezzocannone 16, 80134 Naples, Italy Istituto di Biostrutture e Bioimmagini, CNR, via Mezzocannone 16, 80134 Naples, Italy Facolt di Scienze Biotecnologiche, Universit di Napoli Federico II, via Mezzocannone 16, 80134 Naples, Italy
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Symmetrical glycosyl disulfides can be prepared within a few hours from per-O-acetylated precursors via a sequential approach entailing short reactions and no purification of any intermediate. The final thiolate-to-disulfide oxidation step is noticeably accelerated by low amounts of phenyl diselenide under air. Applicability of the strategy to non-saccharidic symmetrical alkyl disulfides has also been examined. A preliminary assay of the cytotoxic activity of symmetrical 1,1'-disulfides was performed on two human tumor cell lines, and a noteworthy activity was recorded for a range of these synthetic compounds.
88 Records (82 escludendo Abstract e Conferenze). Impact factor totale: 347.772 (327.32 escludendo Abstract e Conferenze). Impact factor a 5 anni totale: 360.309 (336.443 escludendo Abstract e Conferenze).
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