Clickable functionalization of liposomes with the gH625 peptide from herpes simplex virus type i for intracellular drug delivery (433 views visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Nov 4; 17(45): 12659-12668.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article,
Impact factor: 5.925, 5-year impact factor Impact factor a 5 anni: 5.866
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-80054928496&partnerID=40&md5=0b3bf6260df0754d7aabd2f10c9a226c
Keywords Parole chiave: Click Chemistry, Drug Delivery, Liposomes, Peptides, Viruses, 2-Dioleoyl-Sn-Glycero-3-Phosphocholine, Cellular Uptake, Chemotherapeutic Agents, Cytotoxic Drugs, Doxorubicin, Dynamic Light Scattering Measurement, Encapsulated Drugs, External Surfaces, Functionalizations, Herpes Simplex Virus, Intracellular Drug Delivery, Intracellular Uptake, Spin Label, Synthetic Strategies, Tumor Cells, Carboxylic Acids, Confocal Microscopy, Iodine, Paramagnetic Resonance, Phospholipids, Gh625 Peptide, Herpes Simplex Virus Type I, Virus Envelope Protein, Article, Drug Delivery System, Metabolism, Methodology, Herpesvirus 1, Human, Viral Envelope Proteins,
Affiliations Affiliazioni:
*** IBB - CNR ***
Department of Biological Sciences, CIRPeB and IBB CNR, University of Naples Federico II, Via Mezzocannone 16, 80134 Naples, Italy
IIT at CRIB, Center for Advanced Biomaterials in Health Care, Piazzale Tecchio 80, 80125 Naples, Italy
Department of Chemistry, University of Naples Federico II and Consorzio per Lo Studio Dei Sistemi A Grande Interfase, CSGI, Monte Sant'Angelo, 80126, Naples, Italy
References Riferimenti:
Bareford, L.M., Swaan, P.W., (2007) Adv. Drug Delivery Rev., 59, p. 74
Heitz, F., Morris, M.C., Divita, G., (2009) Br. J. Pharmacol., 157, p. 195
Galdiero, S., Vitiello, M., Falanga, A., Cantisani, M., Incoronato, N., Galdiero, M., (2011) Curr. Drug Metab., , DOI: BSP/CDM/E-PUB/00197
Galdiero, S., Falanga, A., Vitiello, M., Browne, H., Pedone, C., Galdiero, M., (2005) J. Biol. Chem., 280, p. 28632
Gregoriadis, G., Ryman, B.E., (1972) Biochem. J., 129, p. 123
Cukierman, E., Khan, D.R., (2010) Biochem. Pharmacol., 80, p. 762
Sharma, A., Sharma, U.S., (1997) Int. J. Pharm., 154, p. 123
Papisov, M.I., (1998) Adv. Drug Delivery Rev., 32, p. 119
Miller, C.R., Bondurant, B., McLean, S.D., McGovern, K.A., Obrien, D.F., (1998) Biochemistry, 37, p. 12875
Maeda, H., Wu, J., Sawa, T., Matsumura, Y., Hori, K., (2000) J. Controlled Release, 65, p. 271
Bally, M.B., Nayar, R., Masin, D., Hope, M.J., Cullis, P.R., Mayer, L.D., (1990) Biochim. Biophys. Acta Biomembr., 1023, p. 133
Allen, T.M., Moase, E.H., (1996) Adv. Drug Delivery Rev., 21, p. 117
Allen, T.M., (1997) Drugs, 54, p. 8
Coukell, A.J., Spencer, C.M., (1997) Drugs, 53, p. 520
Albrizio, S., Giusti, L., Derrico, G., Esposito, C., Porchia, F., Caliendo, G., Novellino, E., D'Ursi, A.M., (2007) J. Med. Chem., 50, p. 1458
Vives, E., Brodin, P., Lebleu, B., (1997) J. Biol. Chem., 272, p. 16010
Tseng, Y.L., Liu, J.J., Hong, R.L., (2002) Mol. Pharmacol., 62, p. 864
Drummond, D.C., Meyer, O., Hong, K., Kirpotin, D.B., Papahadjopoulos, D., (1999) Pharmacol. Rev., 51, p. 691
Kolb, H.C., Finn, M.G., Sharpless, K.B., (2001) Angew. Chem., 113, p. 2056
(2001) Angew. Chem. Int. Ed., 40, p. 2004
Kolb, H.C., Sharpless, K.B., (2003) Drug Discovery Today, 8, p. 1128
Said Hassane, F., Frish, B., Schuber, F., (2006) Bioconjugate Chem., 17, p. 849
Cavalli, S., Tipton, A.R., Overhand, M., Kros, A., (2006) Chem. Commun., p. 3193
Liu, Y., Zhang, L., Wan, J., Li, Y., Xu, Y., Pan, Y., (2008) Tetrahedron, 64, p. 10728
Schneggenburger, P.E., Worbs, B., Diederichsen, U., (2010) J. Pept. Sci., 16, p. 10
Yu, Y.G., Thorgeirsson, T., Shin, Y.K., (1994) Biochemistry, 33, p. 14221
Hanson, P., Millhauser, G., Formaggio, F., Crisma, M., Toniolo, C., (1996) J. Am. Chem. Soc., 118, p. 7618
Vergara, A., Paduano, L., Sartorio, R., (2001) J. Phys. Chem. B, 105, p. 328
Ertel, A., Marangoni, A.G., Marsh, J., Hallett, F.R., Woodt, J.M., (1993) Biophys. J., 64, p. 426
Tardi, P.G., Boman, N.L., Cullis, P.R., (1996) J. Drug Targeting, 4, p. 129
Fritze, A., Hens, F., Kimpfler, A., Schubert, R., Peschka-Süss, R., (2006) Biochim. Biophys. Acta Biomembr., 1758, p. 1633
Siwak, D.R., Tari, A.M., Lopez-Berestein, G., (2002) Clin. Cancer Res., 8, p. 1172
Lasic, D.D., (1998) Trends Biotechnol., 16, p. 307
(2003) Liposomes: A Practical Approach, , 2 nd ed. (Eds.: V. P. Torchilin, V. Weissing), Oxford University, Oxford
Gabizon, A.A., (1992) Cancer Res., 52, p. 891
Moghimi, S.M., Hunter, A.C., Murray, J.C., (2001) Pharmacol. Rev., 53, p. 283
Mot, C., Drummond, D.C., Hong, K., Kirpotin, D.B., Park, J.W., (2003) Drug Resist. Updates, 6, p. 271
Lee, E.S., Na, K., Bae, Y.H., (2005) J. Controlled Release, 103, p. 405
Nakaie, C.R., Schreier, S., Paiva, A.C.M., (1983) Biochim. Biophys. Acta Protein Struct. Mol. Enzymol., 742, p. 63
Barbosa, S.R., Cilli, E.M., Lamy-Freund, M.T., Castrucci, A.M.L., Nakaie, C.R., (1999) FEBS Lett., 446, p. 45
Rapaport, D., Shai, Y., (1991) J. Biol. Chem., 266, p. 23769
Schmitt, L., Dietrich, C., (1994) J. Am. Chem. Soc., 116, p. 8485
Berne, B.J., Pecora, R., (1975) Dynamic Light Scattering with Applications to Chemistry, Biology, and Physics, , Dover, New York
Brehm, G.A., Bloomfield, V.A., (1975) Macromolecules, 8, p. 663
Kveder, M., Pifat, G., Pecar, S., Schara, M., Ramos, P., Esterbauer, H., (1997) Chem. Phys. Lipids, 85, p. 1
Bareford, L. M., Swaan, P. W., (2007) Adv. Drug Delivery Rev., 59, p. 74
Papisov, M. I., (1998) Adv. Drug Delivery Rev., 32, p. 119
Miller, C. R., Bondurant, B., McLean, S. D., McGovern, K. A., Obrien, D. F., (1998) Biochemistry, 37, p. 12875
Bally, M. B., Nayar, R., Masin, D., Hope, M. J., Cullis, P. R., Mayer, L. D., (1990) Biochim. Biophys. Acta Biomembr., 1023, p. 133
Allen, T. M., Moase, E. H., (1996) Adv. Drug Delivery Rev., 21, p. 117
Allen, T. M., (1997) Drugs, 54, p. 8
Coukell, A. J., Spencer, C. M., (1997) Drugs, 53, p. 520
Tseng, Y. L., Liu, J. J., Hong, R. L., (2002) Mol. Pharmacol., 62, p. 864
Drummond, D. C., Meyer, O., Hong, K., Kirpotin, D. B., Papahadjopoulos, D., (1999) Pharmacol. Rev., 51, p. 691
Kolb, H. C., Finn, M. G., Sharpless, K. B., (2001) Angew. Chem., 113, p. 2056
Kolb, H. C., Sharpless, K. B., (2003) Drug Discovery Today, 8, p. 1128
Schneggenburger, P. E., Worbs, B., Diederichsen, U., (2010) J. Pept. Sci., 16, p. 10
Yu, Y. G., Thorgeirsson, T., Shin, Y. K., (1994) Biochemistry, 33, p. 14221
Tardi, P. G., Boman, N. L., Cullis, P. R., (1996) J. Drug Targeting, 4, p. 129
Siwak, D. R., Tari, A. M., Lopez-Berestein, G., (2002) Clin. Cancer Res., 8, p. 1172
Lasic, D. D., (1998) Trends Biotechnol., 16, p. 307
(2003) Liposomes: A Practical Approach, , 2 nd ed. (Eds.: V. P. Torchilin, V. Weissing), Oxford University, Oxford
Gabizon, A. A., (1992) Cancer Res., 52, p. 891
Moghimi, S. M., Hunter, A. C., Murray, J. C., (2001) Pharmacol. Rev., 53, p. 283
Lee, E. S., Na, K., Bae, Y. H., (2005) J. Controlled Release, 103, p. 405
Nakaie, C. R., Schreier, S., Paiva, A. C. M., (1983) Biochim. Biophys. Acta Protein Struct. Mol. Enzymol., 742, p. 63
Barbosa, S. R., Cilli, E. M., Lamy-Freund, M. T., Castrucci, A. M. L., Nakaie, C. R., (1999) FEBS Lett., 446, p. 45
Berne, B. J., Pecora, R., (1975) Dynamic Light Scattering with Applications to Chemistry, Biology, and Physics, , Dover, New York
Brehm, G. A., Bloomfield, V. A., (1975) Macromolecules, 8, p. 663
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Nov 4; 17(45): 12659-12668.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article,
Impact factor: 5.925, 5-year impact factor Impact factor a 5 anni: 5.866
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-80054928496&partnerID=40&md5=0b3bf6260df0754d7aabd2f10c9a226c
Keywords Parole chiave: Click Chemistry, Drug Delivery, Liposomes, Peptides, Viruses, 2-Dioleoyl-Sn-Glycero-3-Phosphocholine, Cellular Uptake, Chemotherapeutic Agents, Cytotoxic Drugs, Doxorubicin, Dynamic Light Scattering Measurement, Encapsulated Drugs, External Surfaces, Functionalizations, Herpes Simplex Virus, Intracellular Drug Delivery, Intracellular Uptake, Spin Label, Synthetic Strategies, Tumor Cells, Carboxylic Acids, Confocal Microscopy, Iodine, Paramagnetic Resonance, Phospholipids, Gh625 Peptide, Herpes Simplex Virus Type I, Virus Envelope Protein, Article, Drug Delivery System, Metabolism, Methodology, Herpesvirus 1, Human, Viral Envelope Proteins,
Affiliations Affiliazioni:
*** IBB - CNR ***
Department of Biological Sciences, CIRPeB and IBB CNR, University of Naples Federico II, Via Mezzocannone 16, 80134 Naples, Italy
IIT at CRIB, Center for Advanced Biomaterials in Health Care, Piazzale Tecchio 80, 80125 Naples, Italy
Department of Chemistry, University of Naples Federico II and Consorzio per Lo Studio Dei Sistemi A Grande Interfase, CSGI, Monte Sant'Angelo, 80126, Naples, Italy
References Riferimenti:
Bareford, L.M., Swaan, P.W., (2007) Adv. Drug Delivery Rev., 59, p. 74
Heitz, F., Morris, M.C., Divita, G., (2009) Br. J. Pharmacol., 157, p. 195
Galdiero, S., Vitiello, M., Falanga, A., Cantisani, M., Incoronato, N., Galdiero, M., (2011) Curr. Drug Metab., , DOI: BSP/CDM/E-PUB/00197
Galdiero, S., Falanga, A., Vitiello, M., Browne, H., Pedone, C., Galdiero, M., (2005) J. Biol. Chem., 280, p. 28632
Gregoriadis, G., Ryman, B.E., (1972) Biochem. J., 129, p. 123
Cukierman, E., Khan, D.R., (2010) Biochem. Pharmacol., 80, p. 762
Sharma, A., Sharma, U.S., (1997) Int. J. Pharm., 154, p. 123
Papisov, M.I., (1998) Adv. Drug Delivery Rev., 32, p. 119
Miller, C.R., Bondurant, B., McLean, S.D., McGovern, K.A., Obrien, D.F., (1998) Biochemistry, 37, p. 12875
Maeda, H., Wu, J., Sawa, T., Matsumura, Y., Hori, K., (2000) J. Controlled Release, 65, p. 271
Bally, M.B., Nayar, R., Masin, D., Hope, M.J., Cullis, P.R., Mayer, L.D., (1990) Biochim. Biophys. Acta Biomembr., 1023, p. 133
Allen, T.M., Moase, E.H., (1996) Adv. Drug Delivery Rev., 21, p. 117
Allen, T.M., (1997) Drugs, 54, p. 8
Coukell, A.J., Spencer, C.M., (1997) Drugs, 53, p. 520
Albrizio, S., Giusti, L., Derrico, G., Esposito, C., Porchia, F., Caliendo, G., Novellino, E., D'Ursi, A.M., (2007) J. Med. Chem., 50, p. 1458
Vives, E., Brodin, P., Lebleu, B., (1997) J. Biol. Chem., 272, p. 16010
Tseng, Y.L., Liu, J.J., Hong, R.L., (2002) Mol. Pharmacol., 62, p. 864
Drummond, D.C., Meyer, O., Hong, K., Kirpotin, D.B., Papahadjopoulos, D., (1999) Pharmacol. Rev., 51, p. 691
Kolb, H.C., Finn, M.G., Sharpless, K.B., (2001) Angew. Chem., 113, p. 2056
(2001) Angew. Chem. Int. Ed., 40, p. 2004
Kolb, H.C., Sharpless, K.B., (2003) Drug Discovery Today, 8, p. 1128
Said Hassane, F., Frish, B., Schuber, F., (2006) Bioconjugate Chem., 17, p. 849
Cavalli, S., Tipton, A.R., Overhand, M., Kros, A., (2006) Chem. Commun., p. 3193
Liu, Y., Zhang, L., Wan, J., Li, Y., Xu, Y., Pan, Y., (2008) Tetrahedron, 64, p. 10728
Schneggenburger, P.E., Worbs, B., Diederichsen, U., (2010) J. Pept. Sci., 16, p. 10
Yu, Y.G., Thorgeirsson, T., Shin, Y.K., (1994) Biochemistry, 33, p. 14221
Hanson, P., Millhauser, G., Formaggio, F., Crisma, M., Toniolo, C., (1996) J. Am. Chem. Soc., 118, p. 7618
Vergara, A., Paduano, L., Sartorio, R., (2001) J. Phys. Chem. B, 105, p. 328
Ertel, A., Marangoni, A.G., Marsh, J., Hallett, F.R., Woodt, J.M., (1993) Biophys. J., 64, p. 426
Tardi, P.G., Boman, N.L., Cullis, P.R., (1996) J. Drug Targeting, 4, p. 129
Fritze, A., Hens, F., Kimpfler, A., Schubert, R., Peschka-Süss, R., (2006) Biochim. Biophys. Acta Biomembr., 1758, p. 1633
Siwak, D.R., Tari, A.M., Lopez-Berestein, G., (2002) Clin. Cancer Res., 8, p. 1172
Lasic, D.D., (1998) Trends Biotechnol., 16, p. 307
(2003) Liposomes: A Practical Approach, , 2 nd ed. (Eds.: V. P. Torchilin, V. Weissing), Oxford University, Oxford
Gabizon, A.A., (1992) Cancer Res., 52, p. 891
Moghimi, S.M., Hunter, A.C., Murray, J.C., (2001) Pharmacol. Rev., 53, p. 283
Mot, C., Drummond, D.C., Hong, K., Kirpotin, D.B., Park, J.W., (2003) Drug Resist. Updates, 6, p. 271
Lee, E.S., Na, K., Bae, Y.H., (2005) J. Controlled Release, 103, p. 405
Nakaie, C.R., Schreier, S., Paiva, A.C.M., (1983) Biochim. Biophys. Acta Protein Struct. Mol. Enzymol., 742, p. 63
Barbosa, S.R., Cilli, E.M., Lamy-Freund, M.T., Castrucci, A.M.L., Nakaie, C.R., (1999) FEBS Lett., 446, p. 45
Rapaport, D., Shai, Y., (1991) J. Biol. Chem., 266, p. 23769
Schmitt, L., Dietrich, C., (1994) J. Am. Chem. Soc., 116, p. 8485
Berne, B.J., Pecora, R., (1975) Dynamic Light Scattering with Applications to Chemistry, Biology, and Physics, , Dover, New York
Brehm, G.A., Bloomfield, V.A., (1975) Macromolecules, 8, p. 663
Kveder, M., Pifat, G., Pecar, S., Schara, M., Ramos, P., Esterbauer, H., (1997) Chem. Phys. Lipids, 85, p. 1
Bareford, L. M., Swaan, P. W., (2007) Adv. Drug Delivery Rev., 59, p. 74
Papisov, M. I., (1998) Adv. Drug Delivery Rev., 32, p. 119
Miller, C. R., Bondurant, B., McLean, S. D., McGovern, K. A., Obrien, D. F., (1998) Biochemistry, 37, p. 12875
Bally, M. B., Nayar, R., Masin, D., Hope, M. J., Cullis, P. R., Mayer, L. D., (1990) Biochim. Biophys. Acta Biomembr., 1023, p. 133
Allen, T. M., Moase, E. H., (1996) Adv. Drug Delivery Rev., 21, p. 117
Allen, T. M., (1997) Drugs, 54, p. 8
Coukell, A. J., Spencer, C. M., (1997) Drugs, 53, p. 520
Tseng, Y. L., Liu, J. J., Hong, R. L., (2002) Mol. Pharmacol., 62, p. 864
Drummond, D. C., Meyer, O., Hong, K., Kirpotin, D. B., Papahadjopoulos, D., (1999) Pharmacol. Rev., 51, p. 691
Kolb, H. C., Finn, M. G., Sharpless, K. B., (2001) Angew. Chem., 113, p. 2056
Kolb, H. C., Sharpless, K. B., (2003) Drug Discovery Today, 8, p. 1128
Schneggenburger, P. E., Worbs, B., Diederichsen, U., (2010) J. Pept. Sci., 16, p. 10
Yu, Y. G., Thorgeirsson, T., Shin, Y. K., (1994) Biochemistry, 33, p. 14221
Tardi, P. G., Boman, N. L., Cullis, P. R., (1996) J. Drug Targeting, 4, p. 129
Siwak, D. R., Tari, A. M., Lopez-Berestein, G., (2002) Clin. Cancer Res., 8, p. 1172
Lasic, D. D., (1998) Trends Biotechnol., 16, p. 307
(2003) Liposomes: A Practical Approach, , 2 nd ed. (Eds.: V. P. Torchilin, V. Weissing), Oxford University, Oxford
Gabizon, A. A., (1992) Cancer Res., 52, p. 891
Moghimi, S. M., Hunter, A. C., Murray, J. C., (2001) Pharmacol. Rev., 53, p. 283
Lee, E. S., Na, K., Bae, Y. H., (2005) J. Controlled Release, 103, p. 405
Nakaie, C. R., Schreier, S., Paiva, A. C. M., (1983) Biochim. Biophys. Acta Protein Struct. Mol. Enzymol., 742, p. 63
Barbosa, S. R., Cilli, E. M., Lamy-Freund, M. T., Castrucci, A. M. L., Nakaie, C. R., (1999) FEBS Lett., 446, p. 45
Berne, B. J., Pecora, R., (1975) Dynamic Light Scattering with Applications to Chemistry, Biology, and Physics, , Dover, New York
Brehm, G. A., Bloomfield, V. A., (1975) Macromolecules, 8, p. 663
Clickable functionalization of liposomes with the gH625 peptide from herpes simplex virus type i for intracellular drug delivery
Liposomes externally modified with the nineteen residues gH625 peptide, previously identified as a membrane-perturbing domain in the gH glycoprotein of Herpes simplex virus type I, have been prepared in order to improve the intracellular uptake of an encapsulated drug. An easy and versatile synthetic strategy, based on click chemistry, has been used to bind, in a controlled way, several copies of the hydrophobic gH625 peptide on the external surface of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPG)-based liposomes. Electron paramagnetic resonance studies, on liposomes derivatized with gH625 peptides, which are modified with the 2,2,6,6-tetramethylpiperidine-1-oxyl-4-amino-4- carboxylic acid (TOAC) spin label in several peptide positions, confirm the positioning of the coupled peptides on the liposome external surface, whereas dynamic light scattering measurements indicate an increase of the diameter of the liposomes of approximately 30-% after peptide introduction. Liposomes have been loaded with the cytotoxic drug doxorubicin and their ability to penetrate inside cells has been evaluated by confocal microscopy experiments. Results suggest that liposomes functionalized with gH625 may act as promising intracellular targeting carriers for efficient delivery of drugs, such as chemotherapeutic agents, into tumor cells. Clickable liposomes for drug delivery: Liposomes, externally modified by click chemistry with the Herpes simplex virus type I derived peptide gH625 for improving cellular uptake of encapsulated drugs, are presented in this study (see picture). The results suggest that the functionalized liposomes may act as promising intracellular targeting carriers for efficient delivery of drugs, such as chemotherapeutic agents, into tumor cells. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Liposomes externally modified with the nineteen residues gH625 peptide, previously identified as a membrane-perturbing domain in the gH glycoprotein of Herpes simplex virus type I, have been prepared in order to improve the intracellular uptake of an encapsulated drug. An easy and versatile synthetic strategy, based on click chemistry, has been used to bind, in a controlled way, several copies of the hydrophobic gH625 peptide on the external surface of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPG)-based liposomes. Electron paramagnetic resonance studies, on liposomes derivatized with gH625 peptides, which are modified with the 2,2,6,6-tetramethylpiperidine-1-oxyl-4-amino-4- carboxylic acid (TOAC) spin label in several peptide positions, confirm the positioning of the coupled peptides on the liposome external surface, whereas dynamic light scattering measurements indicate an increase of the diameter of the liposomes of approximately 30-% after peptide introduction. Liposomes have been loaded with the cytotoxic drug doxorubicin and their ability to penetrate inside cells has been evaluated by confocal microscopy experiments. Results suggest that liposomes functionalized with gH625 may act as promising intracellular targeting carriers for efficient delivery of drugs, such as chemotherapeutic agents, into tumor cells. Clickable liposomes for drug delivery: Liposomes, externally modified by click chemistry with the Herpes simplex virus type I derived peptide gH625 for improving cellular uptake of encapsulated drugs, are presented in this study (see picture). The results suggest that the functionalized liposomes may act as promising intracellular targeting carriers for efficient delivery of drugs, such as chemotherapeutic agents, into tumor cells. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Clickable functionalization of liposomes with the gH625 peptide from herpes simplex virus type i for intracellular drug delivery
Clickable functionalization of liposomes with the gH625 peptide from herpes simplex virus type i for intracellular drug delivery
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* The impact of metabotropic glutamate receptors into active neurodegenerative processes: A "dark side" in the development of new symptomatic treatments for neurologic and psychiatric disorders (266 visite)
Neuropharm (ISSN: 0028-3908, 1873-7064electronic, 0028-3908linking), 2017 Mar 15; 115: 180-192.
Impact Factor: 5.012
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Greco A, Albanese S, Auletta L, De Carlo F, Salvatore M, Howard CM, Claudio PP
* Advances in molecular preclinical therapy mediated by imaging (245 visite) (PDF 202 visite)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1827-1936), 2017 Mar; 61(1): 76-94.
Impact Factor: 2.368
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Martínez-fernández L, Granucci G, Pollum M, Crespo-hernández CE, Persico M, Corral I
* Decoding the Molecular Basis for the Population Mechanism of the Triplet Phototoxic Precursors in UVA Light-Activated Pyrimidine Anticancer Drugs (212 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2017; 23(11): 2619-2627.
Impact Factor: 5.16
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Celentano V, Diana D, Di Salvo C, De Rosa L, Romanelli A, Fattorusso R, D'Andrea LD
* 1, 2, 3-Triazole Bridge as Conformational Constrain in beta-Hairpin Peptides: Analysis of Hydrogen-Bonded Positions (402 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2016 Apr 11; 22(16): 5534-5537.
Impact Factor: 5.317
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Accardo A, Arena F, Gianolio E, Marasco D, Ringhieri P, Boffa C, Bardini P, Aime S, Morelli G
* Diolein based nanostructures as targeted theranostics (408 visite)
J Biomed Nanotechnol (ISSN: 1550-7033), 2016; 12(5): 1076-1088.
Impact Factor: 4.521
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Ringhieri P, Pannunzio A, Boccarelli A, Morelli G, Coluccia M, Tesauro D
* Effect of cisplatin containing liposomes formulated by unsaturated chain-containing lipids on gynecological tumor cells (264 visite)
J Liposome Res (ISSN: 0898-2104), 2016; N/D: 1-6.
Impact Factor: 1.971
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Ringhieri P, Avitabile C, Saviano M, Morelli G, Romanelli A, Accardo A
* The influence of liposomal formulation on the incorporation and retention of PNA oligomers (156 visite)
Colloid Surface B (ISSN: 0927-7765), 2016; 145: 462-469.
Impact Factor: 3.887
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Vincenzi M, Accardo A, Costantini S, Scala S, Portella L, Trotta A, Ronga L, Guillon J, Leone M, Colonna G, Rossi F, Tesauro D
* Intrinsically disordered amphiphilic peptides as potential targets in drug delivery vehicles (375 visite)
Mol Biosyst (ISSN: 1742-206x), 2015 Oct 13; 11(11): 2925-2932.
Impact Factor: 2.829
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Calce E, Monfregola L, Saviano M, De Luca S
* HER2-mediated anticancer drug delivery: strategies to prepare targeting ligands highly specific for the receptor (532 visite)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2015 May 20; 22(21): 2525-2538.
Impact Factor: 3.455
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Galdiero S, Falanga A, Morelli G, Galdiero M
* gH625: A milestone in understanding the many roles of membranotropic peptides (469 visite)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2015 Jan; 1848(PA): 16-25.
Impact Factor: 5.158
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Roviello GN, Musumeci D, Roviello V
* Cationic peptides as RNA compaction agents: A study on the polyA compaction activity of a linear alpha, epsilon-oligo-l-lysine (457 visite)
Int J Pharm (ISSN: 0378-5173, 1873-3476), 2015; 485(1-2): 244-248.
Impact Factor: 3.994
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Nardon C, Boscutti G, Dalla Via L, Ringhieri P, Di Noto V, Morelli G, Accardo A, Fregona D
* CCK8 peptide-labeled Pluronic® F127 micelles as a targeted vehicle of gold-based anticancer chemotherapeutics (356 visite)
Medchemcomm (ISSN: 2040-2503), 2015; 6(1): 155-163.
Impact Factor: 2.319
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Avitabile C, Accardo A, Ringhieri P, Morelli G, Saviano M, Montagner G, Fabbri E, Gallerani E, Gambari R, Romanelli A
* Incorporation of Naked Peptide Nucleic Acids into Liposomes Leads to Fast and Efficient Delivery (411 visite)
Bioconjug Chem (ISSN: 1043-1802, 1520-4812), 2015; 26(8): 1533-1541.
Impact Factor: 4.5
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Ringhieri P, Diaferia C, Galdiero S, Palumbo R, Morelli G, Accardo A
* Liposomal doxorubicin doubly functionalized with CCK8 and R8 peptide sequences for selective intracellular drug delivery (419 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617linking), 2015; 21(5): 415-425.
Impact Factor: 1.951
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Ringhieri P, Iannitti R, Nardon C, Palumbo R, Fregona D, Morelli G, Accardo A
* Target selective micelles for bombesin receptors incorporating Au(III)-dithiocarbamato complexes (361 visite)
Int J Pharm (ISSN: 0378-5173, 1873-3476), 2014 Oct 1; 473(1-2): 194-202.
Impact Factor: 3.65
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Capasso D, De Paola I, Liguoro A, Del Gatto A, Di Gaetano S, Guarnieri D, Saviano M, Zaccaro L
* Rgdechi-Hcit: Alpha V Beta 3 Selective Pro-Apoptotic Peptide As Potential Carrier For Drug Delivery Into Melanoma Metastatic Cells (422 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2014 Sep 23; 9(9): e106441-e106441.
Impact Factor: 3.234
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Oliveri V, Attanasio F, Puglisi A, Spencer J, Sgarlata C, Vecchio G
* Multifunctional 8-hydroxyquinoline-appended cyclodextrins as new inhibitors of metal-induced protein aggregation (530 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2014 Jul 14; 20(29): 8954-8964.
Impact Factor: 5.731
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Galdiero S, Falanga A, Vitiello M, Grieco P, Caraglia M, Morelli G, Galdiero M
* Exploitation of viral properties for intracellular delivery (450 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617linking), 2014 Jul; 20(7): 468-478.
Impact Factor: 1.546
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Accardo A, Ringhieri P, Szekely N, Pipich V, Luchini A, Paduano L, Tesauro D
* Structural insights on nanoparticles containing gadolinium complexes as potential theranostic (402 visite)
Colloid Polym Sci (ISSN: 0303-402x), 2014 May; 292(5): 1121-1127.
Impact Factor: 1.865
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Accardo A, Aloj L, Aurilio M, Morelli G, Tesauro D
* Receptor binding peptides for target-selective delivery of nanoparticles encapsulated drugs (514 visite)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1176-9114linking), 2014 Mar 27; 9(1): 1537-1557.
Impact Factor: 4.383
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Roviello GN, Roviello GN, Musumeci D, Capasso D, Di Gaetano S, Costanzo M, Pedone C
* Synthesis and supramolecular assembly of 1, 3-bis(1 '-uracilyl)-2-propanone (358 visite)
Rsc Adv (ISSN: 2046-2069), 2014; 4(54): 28691-28698.
Impact Factor: 3.84
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Alterio V, Pan P, Parkkila S, Buonanno M, Supuran CT, Monti SM, De Simone G
* The Structural Comparison Between Membrane-Associated Human Carbonic Anhydrases Provides Insights Into Drug Design Of Selective Inhibitors (377 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2014; 101(7): 769-778.
Impact Factor: 2.385
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Clemente F, Arpaia P, Manna C
* Characterization of human skin impedance after electrical treatment for transdermal drug delivery (326 visite)
Measurement (ISSN: 0263-2241), 2013 Nov; 46(9): 3494-3501.
Impact Factor: 1.526
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Galdiero S, Falanga A, Cantisani M, Vitiello M, Morelli G, Galdiero M
* Peptide-Lipid Interactions: Experiments and Applications (801 visite)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067electronic), 2013 Sep; 14(9): 18758-18789.
Impact Factor: 2.339
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Nande R, Greco A, Gossman MS, Lopez JP, Claudio L, Salvatore M, Brunetti A, Denvir J, Howard CM, Claudio PP
* Microbubble-assisted p53, RB, and p130 gene transfer in combination with radiation therapy in prostate cancer (412 visite)
Current Gene Therapy (ISSN: 1875-5631, 1566-5232), 2013 Jun 1; 13(3): 163-174.
Impact Factor: 4.906
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Falciani C, Brunetti J, Lelli B, Accardo A, Tesauro D, Morelli G, Bracci L
* Nanoparticles exposing neurotensin tumor-specific drivers (399 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Apr; 19(4): 198-204.
Impact Factor: 1.862
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Accardo A, Mangiapia G, Paduano L, Morelli G, Tesauro D
* Octreotide labeled aggregates containing platinum complexes as nanovectors for drug delivery (362 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Apr; 19(4): 190-197.
Impact Factor: 1.862
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Calce E, Monfregola L, Sandomenico A, Saviano M, De Luca S
* Fluorescence study for selecting specific ligands toward HER2 receptor: An example of receptor fragment approach (402 visite)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2013 Mar; 61: 116-121.
Impact Factor: 3.432
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Travaglia A, Satriano C, Giuffrida ML, La Mendola D, Rampazzo E, Prodi L, Rizzarelli E
* Electrostatically driven interaction of silica-supported lipid bilayer nanoplatforms and a nerve growth factor-mimicking peptide (292 visite)
Soft Matter (ISSN: 1744-683x), 2013; 9(18): 4648-4654.
Impact Factor: 4.151
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Smaldone G, Falanga A, Capasso D, Guarnieri D, Correale S, Galdiero M, Netti PA, Zollo M, Galdiero S, Di Gaetano S, Pedone E
* gH625 is a viral derived peptide for effective delivery of intrinsically disordered proteins (407 visite)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1178-2013electronic), 2013; 8: 2555-2565.
Impact Factor: 4.195
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Accardo A, Ringhieri P, Tesauro D, Morelli G
* Liposomes derivatized with tetrabranched neurotensin peptides via click chemistry reactions (362 visite)
New J Chem (ISSN: 1144-0546), 2013; 37(11): 3528-3534.
Impact Factor: 3.159
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Berisio R
* Learning from pathogens: Exploiting host-pathogen liaison for therapeutic development (352 visite)
Curr Protein Pept Sci (ISSN: 1389-2037), 2012 Dec; 13(8): 697-698.
Impact Factor: 2.326
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Accardo A, Mansi R, Salzano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Ziaco B, Tesauro D, Aloj L, De Rosa G, Morelli G
* Bombesin peptide antagonist for target-selective delivery of liposomal doxorubicin on cancer cells (373 visite)
Journal Of Drug Targeting (ISSN: 1061-186x), 2012 Nov 21; 21(3): 240-249.
Impact Factor: 2.768
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Roviello GN, Roviello G, Musumeci D, Bucci EM, Pedone C
* Dakin-West reaction on 1-thyminyl acetic acid for the synthesis of 1, 3-bis(1-thyminyl)-2-propanone, a heteroaromatic compound with nucleopeptide-binding properties (393 visite)
Amino Acids (ISSN: 1438-2199, 0939-4451, 1438-2199electronic), 2012 Oct; 43(4): 1615-1623.
Impact Factor: 3.914
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Galdiero S, Vitiello M, Falanga A, Cantisani M, Incoronato N, Galdiero M
* Intracellular Delivery: Exploiting Viral Membranotropic Peptides (568 visite)
Current Drug Metabolism (ISSN: 1389-2002), 2012 Jan; 13(1): 93-104.
Impact Factor: 4.405
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Accardo A, Salsano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Tesauro D, Aloj L, De Rosa G, Morelli G
* Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells: A potential theranostic agent (339 visite)
Int J Nanomed (ISSN: 1176-9114, 1178-2013, 1178-2013electronic), 2012; 7: 2007-2017.
Impact Factor: 3.463
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Falanga A, Vitiello MT, Cantisani M, Tarallo R, Guarnieri D, Mignogna E, Netti P, Pedone C, Galdiero M, Galdiero S
* A peptide derived from herpes simplex virus type 1 glycoprotein H: membrane translocation and applications to the delivery of quantum dots (446 visite)
Nanomedicine (ISSN: 1549-9642, 1549-9634, 1549-9642electronic), 2011 Dec; 7(6): 925-934.
Impact Factor: 6.692
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Falciani C, Accardo A, Brunetti J, Tesauro D, Lelli B, Pini A, Bracci L, Morelli G
* Target-Selective Drug Delivery through Liposomes Labeled with Oligobranched Neurotensin Peptides (502 visite)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2011 Apr 4; 6(4): 678-685.
Impact Factor: 3.151
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Accardo A, Morisco A, Tesauro D, Pedone C, Morelli G
* Naposomes: A new class of peptide-derivatized, target-selective multimodal nanoparticles for imaging and therapeutic applications (387 visite)
Ther Deliv (ISSN: 2041-5990), 2011 Feb; 2(2): 235-257.
Impact Factor: 0
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Morisco A, Accardo A, Tesauro D, Palumbo R, Benedetti E, Morelli G
* Peptide-labeled supramolecular aggregates as selective doxorubicin carriers for delivery to tumor cells (348 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2011; 96(1): 88-96.
Impact Factor: 2.87
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Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment: Challenges and perspectives (560 visite)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 249-258.
Impact Factor: 1.724
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Moccia M, Musumeci D, Roviello GN, Fusco S, Valente M, Bucci EM, Sapio R, Pedonea C, Netti PA
* Preliminary studies on noncovalent hyperbranched polymers based on PNA and DNA building blocks (590 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Oct; 15(10): 647-653.
Impact Factor: 1.807
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Zaccaro L, Del Gatto A, Pedone C, Saviano M
* Peptides for tumour therapy and diagnosis: current status and future directions (785 visite)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2009 Mar; 16(7): 780-795.
Impact Factor: 4.708
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Accardo A, Tesauro D, Morelli G, Del Pozzo L, Pedone C, Tornesello AL, Benedetti E
* Supramolecular aggregates derivatized by CCK8 peptide as selective nanocarriers for drug delivery (339 visite)
Adv Exp Med Biol (ISSN: 0065-2598, 0065-2598print), 2009; 611: 603-604.
Impact Factor: 2.02
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Marasco D, Perretta G, Sabatella M, Ruvo M
* Past and Future Perspectives of Synthetic Peptide Libraries (499 visite)
Curr Protein Pept Sci (ISSN: 1389-2037), 2008 Oct; 9(5): 447-467.
Impact Factor: 3.011
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Accardo A, Tesauro D, Aloj L, Tarallo L, Arra C, Mangiapia G, Vaccaro M, Pedone C, Paduano L, Morelli G
* Peptide-containing aggregates as selective nanocarriers for therapeutics (349 visite)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2008 Apr; 3(4): 594-602.
Impact Factor: 3.15
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Zeni O, Palumbo R, Bernini R, Zeni L, Sarti M, Scarfi MR
* Cytotoxicity investigation on cultured human blood cells treated with single-wall carbon nanotubes (288 visite)
Sensors (ISSN: 1424-3210, 1424-8220, 1424-8220electronic), 2008 Jan; 8(1): 488-499.
Impact Factor: 1.87
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Maggi A, Salvatore M
Molecular imaging (312 visite)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 95-95.
Impact Factor: 1.724
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Del Vecchio S, Zannetti A, Fonti R, Pace L, Salvatore M
* Nuclear imaging in cancer theranostics (566 visite)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 152-163.
Impact Factor: 1.724
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Accardo A, Tesauro D, Mangiapia G, Pedone C, Morelli G
* Nanostructures by self-assembling peptide amphiphile as potential selective drug carriers (403 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2007; 88(2): 115-121.
Impact Factor: 2.389
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Pappalardo M, Milardi D, Grasso D, La Rosa C
* Phase behaviour of polymer-grafted DPPC membranes for drug delivery systems design (292 visite)
Journal Of Thermal Analysis And Calorimetry (ISSN: 1388-6150), 2005 May; 80(2): 413-418.
Impact Factor: 1.425
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Cortesi R, Mischiati C, Borgatti M, Breda L, Romanelli A, Saviano M, Pedone C, Gambari R, Nastruzzi C
* Formulations for natural and peptide nucleic acids based on cationic polymeric submicron particles (359 visite)
The Aaps Journal (ISSN: 1522-1059, 1550-7416), 2004 Jan 20; 6(1): N/D-N/D.
Impact Factor: 1.938
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Borgatti M, Breda L, Cortesi R, Nastruzzi C, Romanelli A, Saviano M, Bianchi N, Mischiati C, Pedone C, Gambari R
* Cationic Liposomes As Delivery Systems For Double-Stranded Pna-Dna Chimeras Exhibiting Decoy Activity Against Nf-Kappab Transcription Factors (371 visite)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 1873-2968, 0006-2952), 2002 Sep 15; 64(4): 609-616.
Impact Factor: 3.542
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62 Records (58 escludendo Abstract e Conferenze).
Impact factor totale: 210.78 (199.625 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 212.355 (196.884 escludendo Abstract e Conferenze).
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Caputo T, Cusano AM, Ruvo M, Aliberti A, Cusano A
* Human Serum Albumin Nanoparticles as a Carrier for On-Demand Sorafenib Delivery (2 visite)
Curr Pharm Biotechnol (ISSN: 1389-2010linking), 2021 Aug 26; N/D: N/D-N/D.
Impact Factor: 2.097
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Doti N, Mardirossian M, Sandomenico A, Ruvo M, Caporale A
* Recent Applications of Retro-Inverso Peptides (2 visite)
Int J Mol Sci (ISSN: 1422-0067linking), 2021 Aug 12; 22(16): N/D-N/D.
Impact Factor: 4.556
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Agnello L, Tortorella S, D’argenio A, Carbone C, Camorani S, Locatelli E, Auletta L, Sorrentino D, Fedele M, Zannetti A, Franchini MC, Cerchia L
* Optimizing cisplatin delivery to triple-negative breast cancer through novel EGFR aptamer-conjugated polymeric nanovectors (5 visite)
J Exp Clin Cancer Res (ISSN: 1756-9966electronic, 0392-9078linking), 2021 Jul 22; 40(1): 239-239.
Impact Factor: 11.161
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Monti A, Sturlese M, Caporale A, Roger JA, Mascanzoni F, Ruvo M, Doti N
* Design, synthesis, structural analysis and biochemical studies of stapled AIF(370-394) analogues as ligand of CypA (66 visite)
Biochim Biophys Acta Gen Subj (ISSN: 0304-4165linking), 2020 Dec; 1864(12): 129717-129717.
Impact Factor: 3.422
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Roviello GN
* Novel insights into nucleoamino acids: biomolecular recognition and aggregation studies of a thymine-conjugated L-phenyl alanine (359 visite)
Amino Acids (ISSN: 1438-2199electronic, 0939-4451linking), 2018 May 15; DOI10.1007/s00726-01: 933-941.
Impact Factor: 3.173
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Honarvar H, Calce E, Doti N, Langella E, Orlova A, Buijs J, D’amato V, Bianco R, Saviano M, Tolmachev V, De Luca S
* Evaluation of HER2-specific peptide ligand for its employment as radiolabeled imaging probe (266 visite)
Sci Rep (ISSN: 2045-2322linking), 2018 Feb 14; 8(1): 2998-2998.
Impact Factor: 4.259
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Riccardi C, Musumeci D, Capuozzo A, Irace C, King S, Russo Krauss I, Paduano L, Montesarchio D
* "dressing up" an Old Drug: An Aminoacyl Lipid for the Functionalization of Ru(III)-Based Anticancer Agents (165 visite)
Acs Biomater Sci Eng (ISSN: 2373-9878), 2018; 4(1): 163-174.
Impact Factor: 0
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Chino M, Leone L, Maglio O, D'Alonzo D, Pirro F, Pavone V, Nastri F, Lombardi A
* A De Novo Heterodimeric Due Ferri Protein Minimizes the Release of Reactive Intermediates in Dioxygen-Dependent Oxidation (223 visite) (PDF 166 visite)
Angew Chem Int Ed (ISSN: 1433-7851, 1521-3773electronic), 2017 Dec 4; 56(49): 15580-15583.
Impact Factor: 12.102
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Marchiori MF, Riul TB, Oliveira Bortot L, Andrade P, Junqueira GG, Foca G, Doti N, Ruvo M, Dias-baruffi M, Carvalho I, Campo VL
* Binding of triazole-linked galactosyl arylsulfonamides to galectin-3 affects Trypanosoma cruzi cell invasion (634 visite)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391), 2017 Nov 1; 25(21): 6049-6059.
Impact Factor: 2.881
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Caraci F, Bruno V, Copani A, Matrisciano F, Nicoletti F, Battaglia G
* The impact of metabotropic glutamate receptors into active neurodegenerative processes: A "dark side" in the development of new symptomatic treatments for neurologic and psychiatric disorders (266 visite)
Neuropharm (ISSN: 0028-3908, 1873-7064electronic, 0028-3908linking), 2017 Mar 15; 115: 180-192.
Impact Factor: 5.012
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Greco A, Albanese S, Auletta L, De Carlo F, Salvatore M, Howard CM, Claudio PP
* Advances in molecular preclinical therapy mediated by imaging (245 visite) (PDF 202 visite)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1827-1936), 2017 Mar; 61(1): 76-94.
Impact Factor: 2.368
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Martínez-fernández L, Granucci G, Pollum M, Crespo-hernández CE, Persico M, Corral I
* Decoding the Molecular Basis for the Population Mechanism of the Triplet Phototoxic Precursors in UVA Light-Activated Pyrimidine Anticancer Drugs (212 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2017; 23(11): 2619-2627.
Impact Factor: 5.16
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Celentano V, Diana D, Di Salvo C, De Rosa L, Romanelli A, Fattorusso R, D'Andrea LD
* 1, 2, 3-Triazole Bridge as Conformational Constrain in beta-Hairpin Peptides: Analysis of Hydrogen-Bonded Positions (402 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2016 Apr 11; 22(16): 5534-5537.
Impact Factor: 5.317
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Accardo A, Arena F, Gianolio E, Marasco D, Ringhieri P, Boffa C, Bardini P, Aime S, Morelli G
* Diolein based nanostructures as targeted theranostics (408 visite)
J Biomed Nanotechnol (ISSN: 1550-7033), 2016; 12(5): 1076-1088.
Impact Factor: 4.521
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Ringhieri P, Pannunzio A, Boccarelli A, Morelli G, Coluccia M, Tesauro D
* Effect of cisplatin containing liposomes formulated by unsaturated chain-containing lipids on gynecological tumor cells (264 visite)
J Liposome Res (ISSN: 0898-2104), 2016; N/D: 1-6.
Impact Factor: 1.971
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Ringhieri P, Avitabile C, Saviano M, Morelli G, Romanelli A, Accardo A
* The influence of liposomal formulation on the incorporation and retention of PNA oligomers (156 visite)
Colloid Surface B (ISSN: 0927-7765), 2016; 145: 462-469.
Impact Factor: 3.887
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Vincenzi M, Accardo A, Costantini S, Scala S, Portella L, Trotta A, Ronga L, Guillon J, Leone M, Colonna G, Rossi F, Tesauro D
* Intrinsically disordered amphiphilic peptides as potential targets in drug delivery vehicles (375 visite)
Mol Biosyst (ISSN: 1742-206x), 2015 Oct 13; 11(11): 2925-2932.
Impact Factor: 2.829
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Calce E, Monfregola L, Saviano M, De Luca S
* HER2-mediated anticancer drug delivery: strategies to prepare targeting ligands highly specific for the receptor (532 visite)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2015 May 20; 22(21): 2525-2538.
Impact Factor: 3.455
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Galdiero S, Falanga A, Morelli G, Galdiero M
* gH625: A milestone in understanding the many roles of membranotropic peptides (469 visite)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2015 Jan; 1848(PA): 16-25.
Impact Factor: 5.158
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Roviello GN, Musumeci D, Roviello V
* Cationic peptides as RNA compaction agents: A study on the polyA compaction activity of a linear alpha, epsilon-oligo-l-lysine (457 visite)
Int J Pharm (ISSN: 0378-5173, 1873-3476), 2015; 485(1-2): 244-248.
Impact Factor: 3.994
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Nardon C, Boscutti G, Dalla Via L, Ringhieri P, Di Noto V, Morelli G, Accardo A, Fregona D
* CCK8 peptide-labeled Pluronic® F127 micelles as a targeted vehicle of gold-based anticancer chemotherapeutics (356 visite)
Medchemcomm (ISSN: 2040-2503), 2015; 6(1): 155-163.
Impact Factor: 2.319
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Avitabile C, Accardo A, Ringhieri P, Morelli G, Saviano M, Montagner G, Fabbri E, Gallerani E, Gambari R, Romanelli A
* Incorporation of Naked Peptide Nucleic Acids into Liposomes Leads to Fast and Efficient Delivery (411 visite)
Bioconjug Chem (ISSN: 1043-1802, 1520-4812), 2015; 26(8): 1533-1541.
Impact Factor: 4.5
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Ringhieri P, Diaferia C, Galdiero S, Palumbo R, Morelli G, Accardo A
* Liposomal doxorubicin doubly functionalized with CCK8 and R8 peptide sequences for selective intracellular drug delivery (419 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617linking), 2015; 21(5): 415-425.
Impact Factor: 1.951
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Ringhieri P, Iannitti R, Nardon C, Palumbo R, Fregona D, Morelli G, Accardo A
* Target selective micelles for bombesin receptors incorporating Au(III)-dithiocarbamato complexes (361 visite)
Int J Pharm (ISSN: 0378-5173, 1873-3476), 2014 Oct 1; 473(1-2): 194-202.
Impact Factor: 3.65
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Capasso D, De Paola I, Liguoro A, Del Gatto A, Di Gaetano S, Guarnieri D, Saviano M, Zaccaro L
* Rgdechi-Hcit: Alpha V Beta 3 Selective Pro-Apoptotic Peptide As Potential Carrier For Drug Delivery Into Melanoma Metastatic Cells (422 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2014 Sep 23; 9(9): e106441-e106441.
Impact Factor: 3.234
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Oliveri V, Attanasio F, Puglisi A, Spencer J, Sgarlata C, Vecchio G
* Multifunctional 8-hydroxyquinoline-appended cyclodextrins as new inhibitors of metal-induced protein aggregation (530 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2014 Jul 14; 20(29): 8954-8964.
Impact Factor: 5.731
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Galdiero S, Falanga A, Vitiello M, Grieco P, Caraglia M, Morelli G, Galdiero M
* Exploitation of viral properties for intracellular delivery (450 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617linking), 2014 Jul; 20(7): 468-478.
Impact Factor: 1.546
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Accardo A, Ringhieri P, Szekely N, Pipich V, Luchini A, Paduano L, Tesauro D
* Structural insights on nanoparticles containing gadolinium complexes as potential theranostic (402 visite)
Colloid Polym Sci (ISSN: 0303-402x), 2014 May; 292(5): 1121-1127.
Impact Factor: 1.865
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Accardo A, Aloj L, Aurilio M, Morelli G, Tesauro D
* Receptor binding peptides for target-selective delivery of nanoparticles encapsulated drugs (514 visite)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1176-9114linking), 2014 Mar 27; 9(1): 1537-1557.
Impact Factor: 4.383
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Roviello GN, Roviello GN, Musumeci D, Capasso D, Di Gaetano S, Costanzo M, Pedone C
* Synthesis and supramolecular assembly of 1, 3-bis(1 '-uracilyl)-2-propanone (358 visite)
Rsc Adv (ISSN: 2046-2069), 2014; 4(54): 28691-28698.
Impact Factor: 3.84
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Alterio V, Pan P, Parkkila S, Buonanno M, Supuran CT, Monti SM, De Simone G
* The Structural Comparison Between Membrane-Associated Human Carbonic Anhydrases Provides Insights Into Drug Design Of Selective Inhibitors (377 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2014; 101(7): 769-778.
Impact Factor: 2.385
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Clemente F, Arpaia P, Manna C
* Characterization of human skin impedance after electrical treatment for transdermal drug delivery (326 visite)
Measurement (ISSN: 0263-2241), 2013 Nov; 46(9): 3494-3501.
Impact Factor: 1.526
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Galdiero S, Falanga A, Cantisani M, Vitiello M, Morelli G, Galdiero M
* Peptide-Lipid Interactions: Experiments and Applications (801 visite)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067electronic), 2013 Sep; 14(9): 18758-18789.
Impact Factor: 2.339
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Nande R, Greco A, Gossman MS, Lopez JP, Claudio L, Salvatore M, Brunetti A, Denvir J, Howard CM, Claudio PP
* Microbubble-assisted p53, RB, and p130 gene transfer in combination with radiation therapy in prostate cancer (412 visite)
Current Gene Therapy (ISSN: 1875-5631, 1566-5232), 2013 Jun 1; 13(3): 163-174.
Impact Factor: 4.906
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Falciani C, Brunetti J, Lelli B, Accardo A, Tesauro D, Morelli G, Bracci L
* Nanoparticles exposing neurotensin tumor-specific drivers (399 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Apr; 19(4): 198-204.
Impact Factor: 1.862
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Accardo A, Mangiapia G, Paduano L, Morelli G, Tesauro D
* Octreotide labeled aggregates containing platinum complexes as nanovectors for drug delivery (362 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Apr; 19(4): 190-197.
Impact Factor: 1.862
Dettagli Esporta in BibTeX Esporta in EndNote
Calce E, Monfregola L, Sandomenico A, Saviano M, De Luca S
* Fluorescence study for selecting specific ligands toward HER2 receptor: An example of receptor fragment approach (402 visite)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2013 Mar; 61: 116-121.
Impact Factor: 3.432
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Travaglia A, Satriano C, Giuffrida ML, La Mendola D, Rampazzo E, Prodi L, Rizzarelli E
* Electrostatically driven interaction of silica-supported lipid bilayer nanoplatforms and a nerve growth factor-mimicking peptide (292 visite)
Soft Matter (ISSN: 1744-683x), 2013; 9(18): 4648-4654.
Impact Factor: 4.151
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Smaldone G, Falanga A, Capasso D, Guarnieri D, Correale S, Galdiero M, Netti PA, Zollo M, Galdiero S, Di Gaetano S, Pedone E
* gH625 is a viral derived peptide for effective delivery of intrinsically disordered proteins (407 visite)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1178-2013electronic), 2013; 8: 2555-2565.
Impact Factor: 4.195
Dettagli Esporta in BibTeX Esporta in EndNote
Accardo A, Ringhieri P, Tesauro D, Morelli G
* Liposomes derivatized with tetrabranched neurotensin peptides via click chemistry reactions (362 visite)
New J Chem (ISSN: 1144-0546), 2013; 37(11): 3528-3534.
Impact Factor: 3.159
Dettagli Esporta in BibTeX Esporta in EndNote
Berisio R
* Learning from pathogens: Exploiting host-pathogen liaison for therapeutic development (352 visite)
Curr Protein Pept Sci (ISSN: 1389-2037), 2012 Dec; 13(8): 697-698.
Impact Factor: 2.326
Dettagli Esporta in BibTeX Esporta in EndNote
Accardo A, Mansi R, Salzano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Ziaco B, Tesauro D, Aloj L, De Rosa G, Morelli G
* Bombesin peptide antagonist for target-selective delivery of liposomal doxorubicin on cancer cells (373 visite)
Journal Of Drug Targeting (ISSN: 1061-186x), 2012 Nov 21; 21(3): 240-249.
Impact Factor: 2.768
Dettagli Esporta in BibTeX Esporta in EndNote
Roviello GN, Roviello G, Musumeci D, Bucci EM, Pedone C
* Dakin-West reaction on 1-thyminyl acetic acid for the synthesis of 1, 3-bis(1-thyminyl)-2-propanone, a heteroaromatic compound with nucleopeptide-binding properties (393 visite)
Amino Acids (ISSN: 1438-2199, 0939-4451, 1438-2199electronic), 2012 Oct; 43(4): 1615-1623.
Impact Factor: 3.914
Dettagli Esporta in BibTeX Esporta in EndNote
Galdiero S, Vitiello M, Falanga A, Cantisani M, Incoronato N, Galdiero M
* Intracellular Delivery: Exploiting Viral Membranotropic Peptides (568 visite)
Current Drug Metabolism (ISSN: 1389-2002), 2012 Jan; 13(1): 93-104.
Impact Factor: 4.405
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Accardo A, Salsano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Tesauro D, Aloj L, De Rosa G, Morelli G
* Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells: A potential theranostic agent (339 visite)
Int J Nanomed (ISSN: 1176-9114, 1178-2013, 1178-2013electronic), 2012; 7: 2007-2017.
Impact Factor: 3.463
Dettagli Esporta in BibTeX Esporta in EndNote
Falanga A, Vitiello MT, Cantisani M, Tarallo R, Guarnieri D, Mignogna E, Netti P, Pedone C, Galdiero M, Galdiero S
* A peptide derived from herpes simplex virus type 1 glycoprotein H: membrane translocation and applications to the delivery of quantum dots (446 visite)
Nanomedicine (ISSN: 1549-9642, 1549-9634, 1549-9642electronic), 2011 Dec; 7(6): 925-934.
Impact Factor: 6.692
Dettagli Esporta in BibTeX Esporta in EndNote
Falciani C, Accardo A, Brunetti J, Tesauro D, Lelli B, Pini A, Bracci L, Morelli G
* Target-Selective Drug Delivery through Liposomes Labeled with Oligobranched Neurotensin Peptides (502 visite)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2011 Apr 4; 6(4): 678-685.
Impact Factor: 3.151
Dettagli Esporta in BibTeX Esporta in EndNote
Accardo A, Morisco A, Tesauro D, Pedone C, Morelli G
* Naposomes: A new class of peptide-derivatized, target-selective multimodal nanoparticles for imaging and therapeutic applications (387 visite)
Ther Deliv (ISSN: 2041-5990), 2011 Feb; 2(2): 235-257.
Impact Factor: 0
Dettagli Esporta in BibTeX Esporta in EndNote
Morisco A, Accardo A, Tesauro D, Palumbo R, Benedetti E, Morelli G
* Peptide-labeled supramolecular aggregates as selective doxorubicin carriers for delivery to tumor cells (348 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2011; 96(1): 88-96.
Impact Factor: 2.87
Dettagli Esporta in BibTeX Esporta in EndNote
Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment: Challenges and perspectives (560 visite)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 249-258.
Impact Factor: 1.724
Dettagli Esporta in BibTeX Esporta in EndNote
Moccia M, Musumeci D, Roviello GN, Fusco S, Valente M, Bucci EM, Sapio R, Pedonea C, Netti PA
* Preliminary studies on noncovalent hyperbranched polymers based on PNA and DNA building blocks (590 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Oct; 15(10): 647-653.
Impact Factor: 1.807
Dettagli Esporta in BibTeX Esporta in EndNote
Zaccaro L, Del Gatto A, Pedone C, Saviano M
* Peptides for tumour therapy and diagnosis: current status and future directions (785 visite)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2009 Mar; 16(7): 780-795.
Impact Factor: 4.708
Dettagli Esporta in BibTeX Esporta in EndNote
Accardo A, Tesauro D, Morelli G, Del Pozzo L, Pedone C, Tornesello AL, Benedetti E
* Supramolecular aggregates derivatized by CCK8 peptide as selective nanocarriers for drug delivery (339 visite)
Adv Exp Med Biol (ISSN: 0065-2598, 0065-2598print), 2009; 611: 603-604.
Impact Factor: 2.02
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Marasco D, Perretta G, Sabatella M, Ruvo M
* Past and Future Perspectives of Synthetic Peptide Libraries (499 visite)
Curr Protein Pept Sci (ISSN: 1389-2037), 2008 Oct; 9(5): 447-467.
Impact Factor: 3.011
Dettagli Esporta in BibTeX Esporta in EndNote
Accardo A, Tesauro D, Aloj L, Tarallo L, Arra C, Mangiapia G, Vaccaro M, Pedone C, Paduano L, Morelli G
* Peptide-containing aggregates as selective nanocarriers for therapeutics (349 visite)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2008 Apr; 3(4): 594-602.
Impact Factor: 3.15
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Zeni O, Palumbo R, Bernini R, Zeni L, Sarti M, Scarfi MR
* Cytotoxicity investigation on cultured human blood cells treated with single-wall carbon nanotubes (288 visite)
Sensors (ISSN: 1424-3210, 1424-8220, 1424-8220electronic), 2008 Jan; 8(1): 488-499.
Impact Factor: 1.87
Dettagli Esporta in BibTeX Esporta in EndNote
Maggi A, Salvatore M
Molecular imaging (312 visite)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 95-95.
Impact Factor: 1.724
Dettagli Esporta in BibTeX Esporta in EndNote
Del Vecchio S, Zannetti A, Fonti R, Pace L, Salvatore M
* Nuclear imaging in cancer theranostics (566 visite)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 152-163.
Impact Factor: 1.724
Dettagli Esporta in BibTeX Esporta in EndNote
Accardo A, Tesauro D, Mangiapia G, Pedone C, Morelli G
* Nanostructures by self-assembling peptide amphiphile as potential selective drug carriers (403 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2007; 88(2): 115-121.
Impact Factor: 2.389
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Pappalardo M, Milardi D, Grasso D, La Rosa C
* Phase behaviour of polymer-grafted DPPC membranes for drug delivery systems design (292 visite)
Journal Of Thermal Analysis And Calorimetry (ISSN: 1388-6150), 2005 May; 80(2): 413-418.
Impact Factor: 1.425
Dettagli Esporta in BibTeX Esporta in EndNote
Cortesi R, Mischiati C, Borgatti M, Breda L, Romanelli A, Saviano M, Pedone C, Gambari R, Nastruzzi C
* Formulations for natural and peptide nucleic acids based on cationic polymeric submicron particles (359 visite)
The Aaps Journal (ISSN: 1522-1059, 1550-7416), 2004 Jan 20; 6(1): N/D-N/D.
Impact Factor: 1.938
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Borgatti M, Breda L, Cortesi R, Nastruzzi C, Romanelli A, Saviano M, Bianchi N, Mischiati C, Pedone C, Gambari R
* Cationic Liposomes As Delivery Systems For Double-Stranded Pna-Dna Chimeras Exhibiting Decoy Activity Against Nf-Kappab Transcription Factors (371 visite)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 1873-2968, 0006-2952), 2002 Sep 15; 64(4): 609-616.
Impact Factor: 3.542
Dettagli Esporta in BibTeX Esporta in EndNote
62 Records (58 escludendo Abstract e Conferenze).
Impact factor totale: 210.78 (199.625 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 212.355 (196.884 escludendo Abstract e Conferenze).
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