Clickable functionalization of liposomes with the gH625 peptide from herpes simplex virus type i for intracellular drug delivery (437 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Nov 4; 17(45): 12659-12668.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 5.925, 5-year impact factor: 5.866
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-80054928496&partnerID=40&md5=0b3bf6260df0754d7aabd2f10c9a226c
Keywords: Click Chemistry, Drug Delivery, Liposomes, Peptides, Viruses, 2-Dioleoyl-Sn-Glycero-3-Phosphocholine, Cellular Uptake, Chemotherapeutic Agents, Cytotoxic Drugs, Doxorubicin, Dynamic Light Scattering Measurement, Encapsulated Drugs, External Surfaces, Functionalizations, Herpes Simplex Virus, Intracellular Drug Delivery, Intracellular Uptake, Spin Label, Synthetic Strategies, Tumor Cells, Carboxylic Acids, Confocal Microscopy, Iodine, Paramagnetic Resonance, Phospholipids, Gh625 Peptide, Herpes Simplex Virus Type I, Virus Envelope Protein, Article, Drug Delivery System, Metabolism, Methodology, Herpesvirus 1, Human, Viral Envelope Proteins,
Affiliations:
*** IBB - CNR ***
Department of Biological Sciences, CIRPeB and IBB CNR, University of Naples Federico II, Via Mezzocannone 16, 80134 Naples, Italy
IIT at CRIB, Center for Advanced Biomaterials in Health Care, Piazzale Tecchio 80, 80125 Naples, Italy
Department of Chemistry, University of Naples Federico II and Consorzio per Lo Studio Dei Sistemi A Grande Interfase, CSGI, Monte Sant'Angelo, 80126, Naples, Italy
References:
Bareford, L.M., Swaan, P.W., (2007) Adv. Drug Delivery Rev., 59, p. 74
Heitz, F., Morris, M.C., Divita, G., (2009) Br. J. Pharmacol., 157, p. 195
Galdiero, S., Vitiello, M., Falanga, A., Cantisani, M., Incoronato, N., Galdiero, M., (2011) Curr. Drug Metab., , DOI: BSP/CDM/E-PUB/00197
Galdiero, S., Falanga, A., Vitiello, M., Browne, H., Pedone, C., Galdiero, M., (2005) J. Biol. Chem., 280, p. 28632
Gregoriadis, G., Ryman, B.E., (1972) Biochem. J., 129, p. 123
Cukierman, E., Khan, D.R., (2010) Biochem. Pharmacol., 80, p. 762
Sharma, A., Sharma, U.S., (1997) Int. J. Pharm., 154, p. 123
Papisov, M.I., (1998) Adv. Drug Delivery Rev., 32, p. 119
Miller, C.R., Bondurant, B., McLean, S.D., McGovern, K.A., Obrien, D.F., (1998) Biochemistry, 37, p. 12875
Maeda, H., Wu, J., Sawa, T., Matsumura, Y., Hori, K., (2000) J. Controlled Release, 65, p. 271
Bally, M.B., Nayar, R., Masin, D., Hope, M.J., Cullis, P.R., Mayer, L.D., (1990) Biochim. Biophys. Acta Biomembr., 1023, p. 133
Allen, T.M., Moase, E.H., (1996) Adv. Drug Delivery Rev., 21, p. 117
Allen, T.M., (1997) Drugs, 54, p. 8
Coukell, A.J., Spencer, C.M., (1997) Drugs, 53, p. 520
Albrizio, S., Giusti, L., Derrico, G., Esposito, C., Porchia, F., Caliendo, G., Novellino, E., D'Ursi, A.M., (2007) J. Med. Chem., 50, p. 1458
Vives, E., Brodin, P., Lebleu, B., (1997) J. Biol. Chem., 272, p. 16010
Tseng, Y.L., Liu, J.J., Hong, R.L., (2002) Mol. Pharmacol., 62, p. 864
Drummond, D.C., Meyer, O., Hong, K., Kirpotin, D.B., Papahadjopoulos, D., (1999) Pharmacol. Rev., 51, p. 691
Kolb, H.C., Finn, M.G., Sharpless, K.B., (2001) Angew. Chem., 113, p. 2056
(2001) Angew. Chem. Int. Ed., 40, p. 2004
Kolb, H.C., Sharpless, K.B., (2003) Drug Discovery Today, 8, p. 1128
Said Hassane, F., Frish, B., Schuber, F., (2006) Bioconjugate Chem., 17, p. 849
Cavalli, S., Tipton, A.R., Overhand, M., Kros, A., (2006) Chem. Commun., p. 3193
Liu, Y., Zhang, L., Wan, J., Li, Y., Xu, Y., Pan, Y., (2008) Tetrahedron, 64, p. 10728
Schneggenburger, P.E., Worbs, B., Diederichsen, U., (2010) J. Pept. Sci., 16, p. 10
Yu, Y.G., Thorgeirsson, T., Shin, Y.K., (1994) Biochemistry, 33, p. 14221
Hanson, P., Millhauser, G., Formaggio, F., Crisma, M., Toniolo, C., (1996) J. Am. Chem. Soc., 118, p. 7618
Vergara, A., Paduano, L., Sartorio, R., (2001) J. Phys. Chem. B, 105, p. 328
Ertel, A., Marangoni, A.G., Marsh, J., Hallett, F.R., Woodt, J.M., (1993) Biophys. J., 64, p. 426
Tardi, P.G., Boman, N.L., Cullis, P.R., (1996) J. Drug Targeting, 4, p. 129
Fritze, A., Hens, F., Kimpfler, A., Schubert, R., Peschka-Süss, R., (2006) Biochim. Biophys. Acta Biomembr., 1758, p. 1633
Siwak, D.R., Tari, A.M., Lopez-Berestein, G., (2002) Clin. Cancer Res., 8, p. 1172
Lasic, D.D., (1998) Trends Biotechnol., 16, p. 307
(2003) Liposomes: A Practical Approach, , 2 nd ed. (Eds.: V. P. Torchilin, V. Weissing), Oxford University, Oxford
Gabizon, A.A., (1992) Cancer Res., 52, p. 891
Moghimi, S.M., Hunter, A.C., Murray, J.C., (2001) Pharmacol. Rev., 53, p. 283
Mot, C., Drummond, D.C., Hong, K., Kirpotin, D.B., Park, J.W., (2003) Drug Resist. Updates, 6, p. 271
Lee, E.S., Na, K., Bae, Y.H., (2005) J. Controlled Release, 103, p. 405
Nakaie, C.R., Schreier, S., Paiva, A.C.M., (1983) Biochim. Biophys. Acta Protein Struct. Mol. Enzymol., 742, p. 63
Barbosa, S.R., Cilli, E.M., Lamy-Freund, M.T., Castrucci, A.M.L., Nakaie, C.R., (1999) FEBS Lett., 446, p. 45
Rapaport, D., Shai, Y., (1991) J. Biol. Chem., 266, p. 23769
Schmitt, L., Dietrich, C., (1994) J. Am. Chem. Soc., 116, p. 8485
Berne, B.J., Pecora, R., (1975) Dynamic Light Scattering with Applications to Chemistry, Biology, and Physics, , Dover, New York
Brehm, G.A., Bloomfield, V.A., (1975) Macromolecules, 8, p. 663
Kveder, M., Pifat, G., Pecar, S., Schara, M., Ramos, P., Esterbauer, H., (1997) Chem. Phys. Lipids, 85, p. 1
Bareford, L. M., Swaan, P. W., (2007) Adv. Drug Delivery Rev., 59, p. 74
Papisov, M. I., (1998) Adv. Drug Delivery Rev., 32, p. 119
Miller, C. R., Bondurant, B., McLean, S. D., McGovern, K. A., Obrien, D. F., (1998) Biochemistry, 37, p. 12875
Bally, M. B., Nayar, R., Masin, D., Hope, M. J., Cullis, P. R., Mayer, L. D., (1990) Biochim. Biophys. Acta Biomembr., 1023, p. 133
Allen, T. M., Moase, E. H., (1996) Adv. Drug Delivery Rev., 21, p. 117
Allen, T. M., (1997) Drugs, 54, p. 8
Coukell, A. J., Spencer, C. M., (1997) Drugs, 53, p. 520
Tseng, Y. L., Liu, J. J., Hong, R. L., (2002) Mol. Pharmacol., 62, p. 864
Drummond, D. C., Meyer, O., Hong, K., Kirpotin, D. B., Papahadjopoulos, D., (1999) Pharmacol. Rev., 51, p. 691
Kolb, H. C., Finn, M. G., Sharpless, K. B., (2001) Angew. Chem., 113, p. 2056
Kolb, H. C., Sharpless, K. B., (2003) Drug Discovery Today, 8, p. 1128
Yu, Y. G., Thorgeirsson, T., Shin, Y. K., (1994) Biochemistry, 33, p. 14221
Tardi, P. G., Boman, N. L., Cullis, P. R., (1996) J. Drug Targeting, 4, p. 129
Siwak, D. R., Tari, A. M., Lopez-Berestein, G., (2002) Clin. Cancer Res., 8, p. 1172
Lasic, D. D., (1998) Trends Biotechnol., 16, p. 307
(2003) Liposomes: A Practical Approach, , 2 nd ed. (Eds.: V. P. Torchilin, V. Weissing), Oxford University, Oxford
Gabizon, A. A., (1992) Cancer Res., 52, p. 891
Moghimi, S. M., Hunter, A. C., Murray, J. C., (2001) Pharmacol. Rev., 53, p. 283
Lee, E. S., Na, K., Bae, Y. H., (2005) J. Controlled Release, 103, p. 405
Nakaie, C. R., Schreier, S., Paiva, A. C. M., (1983) Biochim. Biophys. Acta Protein Struct. Mol. Enzymol., 742, p. 63
Barbosa, S. R., Cilli, E. M., Lamy-Freund, M. T., Castrucci, A. M. L., Nakaie, C. R., (1999) FEBS Lett., 446, p. 45
Berne, B. J., Pecora, R., (1975) Dynamic Light Scattering with Applications to Chemistry, Biology, and Physics, , Dover, New York
Brehm, G. A., Bloomfield, V. A., (1975) Macromolecules, 8, p. 663
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Nov 4; 17(45): 12659-12668.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 5.925, 5-year impact factor: 5.866
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-80054928496&partnerID=40&md5=0b3bf6260df0754d7aabd2f10c9a226c
Keywords: Click Chemistry, Drug Delivery, Liposomes, Peptides, Viruses, 2-Dioleoyl-Sn-Glycero-3-Phosphocholine, Cellular Uptake, Chemotherapeutic Agents, Cytotoxic Drugs, Doxorubicin, Dynamic Light Scattering Measurement, Encapsulated Drugs, External Surfaces, Functionalizations, Herpes Simplex Virus, Intracellular Drug Delivery, Intracellular Uptake, Spin Label, Synthetic Strategies, Tumor Cells, Carboxylic Acids, Confocal Microscopy, Iodine, Paramagnetic Resonance, Phospholipids, Gh625 Peptide, Herpes Simplex Virus Type I, Virus Envelope Protein, Article, Drug Delivery System, Metabolism, Methodology, Herpesvirus 1, Human, Viral Envelope Proteins,
Affiliations:
*** IBB - CNR ***
Department of Biological Sciences, CIRPeB and IBB CNR, University of Naples Federico II, Via Mezzocannone 16, 80134 Naples, Italy
IIT at CRIB, Center for Advanced Biomaterials in Health Care, Piazzale Tecchio 80, 80125 Naples, Italy
Department of Chemistry, University of Naples Federico II and Consorzio per Lo Studio Dei Sistemi A Grande Interfase, CSGI, Monte Sant'Angelo, 80126, Naples, Italy
References:
Bareford, L.M., Swaan, P.W., (2007) Adv. Drug Delivery Rev., 59, p. 74
Heitz, F., Morris, M.C., Divita, G., (2009) Br. J. Pharmacol., 157, p. 195
Galdiero, S., Vitiello, M., Falanga, A., Cantisani, M., Incoronato, N., Galdiero, M., (2011) Curr. Drug Metab., , DOI: BSP/CDM/E-PUB/00197
Galdiero, S., Falanga, A., Vitiello, M., Browne, H., Pedone, C., Galdiero, M., (2005) J. Biol. Chem., 280, p. 28632
Gregoriadis, G., Ryman, B.E., (1972) Biochem. J., 129, p. 123
Cukierman, E., Khan, D.R., (2010) Biochem. Pharmacol., 80, p. 762
Sharma, A., Sharma, U.S., (1997) Int. J. Pharm., 154, p. 123
Papisov, M.I., (1998) Adv. Drug Delivery Rev., 32, p. 119
Miller, C.R., Bondurant, B., McLean, S.D., McGovern, K.A., Obrien, D.F., (1998) Biochemistry, 37, p. 12875
Maeda, H., Wu, J., Sawa, T., Matsumura, Y., Hori, K., (2000) J. Controlled Release, 65, p. 271
Bally, M.B., Nayar, R., Masin, D., Hope, M.J., Cullis, P.R., Mayer, L.D., (1990) Biochim. Biophys. Acta Biomembr., 1023, p. 133
Allen, T.M., Moase, E.H., (1996) Adv. Drug Delivery Rev., 21, p. 117
Allen, T.M., (1997) Drugs, 54, p. 8
Coukell, A.J., Spencer, C.M., (1997) Drugs, 53, p. 520
Albrizio, S., Giusti, L., Derrico, G., Esposito, C., Porchia, F., Caliendo, G., Novellino, E., D'Ursi, A.M., (2007) J. Med. Chem., 50, p. 1458
Vives, E., Brodin, P., Lebleu, B., (1997) J. Biol. Chem., 272, p. 16010
Tseng, Y.L., Liu, J.J., Hong, R.L., (2002) Mol. Pharmacol., 62, p. 864
Drummond, D.C., Meyer, O., Hong, K., Kirpotin, D.B., Papahadjopoulos, D., (1999) Pharmacol. Rev., 51, p. 691
Kolb, H.C., Finn, M.G., Sharpless, K.B., (2001) Angew. Chem., 113, p. 2056
(2001) Angew. Chem. Int. Ed., 40, p. 2004
Kolb, H.C., Sharpless, K.B., (2003) Drug Discovery Today, 8, p. 1128
Said Hassane, F., Frish, B., Schuber, F., (2006) Bioconjugate Chem., 17, p. 849
Cavalli, S., Tipton, A.R., Overhand, M., Kros, A., (2006) Chem. Commun., p. 3193
Liu, Y., Zhang, L., Wan, J., Li, Y., Xu, Y., Pan, Y., (2008) Tetrahedron, 64, p. 10728
Schneggenburger, P.E., Worbs, B., Diederichsen, U., (2010) J. Pept. Sci., 16, p. 10
Yu, Y.G., Thorgeirsson, T., Shin, Y.K., (1994) Biochemistry, 33, p. 14221
Hanson, P., Millhauser, G., Formaggio, F., Crisma, M., Toniolo, C., (1996) J. Am. Chem. Soc., 118, p. 7618
Vergara, A., Paduano, L., Sartorio, R., (2001) J. Phys. Chem. B, 105, p. 328
Ertel, A., Marangoni, A.G., Marsh, J., Hallett, F.R., Woodt, J.M., (1993) Biophys. J., 64, p. 426
Tardi, P.G., Boman, N.L., Cullis, P.R., (1996) J. Drug Targeting, 4, p. 129
Fritze, A., Hens, F., Kimpfler, A., Schubert, R., Peschka-Süss, R., (2006) Biochim. Biophys. Acta Biomembr., 1758, p. 1633
Siwak, D.R., Tari, A.M., Lopez-Berestein, G., (2002) Clin. Cancer Res., 8, p. 1172
Lasic, D.D., (1998) Trends Biotechnol., 16, p. 307
(2003) Liposomes: A Practical Approach, , 2 nd ed. (Eds.: V. P. Torchilin, V. Weissing), Oxford University, Oxford
Gabizon, A.A., (1992) Cancer Res., 52, p. 891
Moghimi, S.M., Hunter, A.C., Murray, J.C., (2001) Pharmacol. Rev., 53, p. 283
Mot, C., Drummond, D.C., Hong, K., Kirpotin, D.B., Park, J.W., (2003) Drug Resist. Updates, 6, p. 271
Lee, E.S., Na, K., Bae, Y.H., (2005) J. Controlled Release, 103, p. 405
Nakaie, C.R., Schreier, S., Paiva, A.C.M., (1983) Biochim. Biophys. Acta Protein Struct. Mol. Enzymol., 742, p. 63
Barbosa, S.R., Cilli, E.M., Lamy-Freund, M.T., Castrucci, A.M.L., Nakaie, C.R., (1999) FEBS Lett., 446, p. 45
Rapaport, D., Shai, Y., (1991) J. Biol. Chem., 266, p. 23769
Schmitt, L., Dietrich, C., (1994) J. Am. Chem. Soc., 116, p. 8485
Berne, B.J., Pecora, R., (1975) Dynamic Light Scattering with Applications to Chemistry, Biology, and Physics, , Dover, New York
Brehm, G.A., Bloomfield, V.A., (1975) Macromolecules, 8, p. 663
Kveder, M., Pifat, G., Pecar, S., Schara, M., Ramos, P., Esterbauer, H., (1997) Chem. Phys. Lipids, 85, p. 1
Bareford, L. M., Swaan, P. W., (2007) Adv. Drug Delivery Rev., 59, p. 74
Papisov, M. I., (1998) Adv. Drug Delivery Rev., 32, p. 119
Miller, C. R., Bondurant, B., McLean, S. D., McGovern, K. A., Obrien, D. F., (1998) Biochemistry, 37, p. 12875
Bally, M. B., Nayar, R., Masin, D., Hope, M. J., Cullis, P. R., Mayer, L. D., (1990) Biochim. Biophys. Acta Biomembr., 1023, p. 133
Allen, T. M., Moase, E. H., (1996) Adv. Drug Delivery Rev., 21, p. 117
Allen, T. M., (1997) Drugs, 54, p. 8
Coukell, A. J., Spencer, C. M., (1997) Drugs, 53, p. 520
Tseng, Y. L., Liu, J. J., Hong, R. L., (2002) Mol. Pharmacol., 62, p. 864
Drummond, D. C., Meyer, O., Hong, K., Kirpotin, D. B., Papahadjopoulos, D., (1999) Pharmacol. Rev., 51, p. 691
Kolb, H. C., Finn, M. G., Sharpless, K. B., (2001) Angew. Chem., 113, p. 2056
Kolb, H. C., Sharpless, K. B., (2003) Drug Discovery Today, 8, p. 1128
Yu, Y. G., Thorgeirsson, T., Shin, Y. K., (1994) Biochemistry, 33, p. 14221
Tardi, P. G., Boman, N. L., Cullis, P. R., (1996) J. Drug Targeting, 4, p. 129
Siwak, D. R., Tari, A. M., Lopez-Berestein, G., (2002) Clin. Cancer Res., 8, p. 1172
Lasic, D. D., (1998) Trends Biotechnol., 16, p. 307
(2003) Liposomes: A Practical Approach, , 2 nd ed. (Eds.: V. P. Torchilin, V. Weissing), Oxford University, Oxford
Gabizon, A. A., (1992) Cancer Res., 52, p. 891
Moghimi, S. M., Hunter, A. C., Murray, J. C., (2001) Pharmacol. Rev., 53, p. 283
Lee, E. S., Na, K., Bae, Y. H., (2005) J. Controlled Release, 103, p. 405
Nakaie, C. R., Schreier, S., Paiva, A. C. M., (1983) Biochim. Biophys. Acta Protein Struct. Mol. Enzymol., 742, p. 63
Barbosa, S. R., Cilli, E. M., Lamy-Freund, M. T., Castrucci, A. M. L., Nakaie, C. R., (1999) FEBS Lett., 446, p. 45
Berne, B. J., Pecora, R., (1975) Dynamic Light Scattering with Applications to Chemistry, Biology, and Physics, , Dover, New York
Brehm, G. A., Bloomfield, V. A., (1975) Macromolecules, 8, p. 663
Clickable functionalization of liposomes with the gH625 peptide from herpes simplex virus type i for intracellular drug delivery
Liposomes externally modified with the nineteen residues gH625 peptide, previously identified as a membrane-perturbing domain in the gH glycoprotein of Herpes simplex virus type I, have been prepared in order to improve the intracellular uptake of an encapsulated drug. An easy and versatile synthetic strategy, based on click chemistry, has been used to bind, in a controlled way, several copies of the hydrophobic gH625 peptide on the external surface of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPG)-based liposomes. Electron paramagnetic resonance studies, on liposomes derivatized with gH625 peptides, which are modified with the 2,2,6,6-tetramethylpiperidine-1-oxyl-4-amino-4- carboxylic acid (TOAC) spin label in several peptide positions, confirm the positioning of the coupled peptides on the liposome external surface, whereas dynamic light scattering measurements indicate an increase of the diameter of the liposomes of approximately 30-% after peptide introduction. Liposomes have been loaded with the cytotoxic drug doxorubicin and their ability to penetrate inside cells has been evaluated by confocal microscopy experiments. Results suggest that liposomes functionalized with gH625 may act as promising intracellular targeting carriers for efficient delivery of drugs, such as chemotherapeutic agents, into tumor cells. Clickable liposomes for drug delivery: Liposomes, externally modified by click chemistry with the Herpes simplex virus type I derived peptide gH625 for improving cellular uptake of encapsulated drugs, are presented in this study (see picture). The results suggest that the functionalized liposomes may act as promising intracellular targeting carriers for efficient delivery of drugs, such as chemotherapeutic agents, into tumor cells. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Liposomes externally modified with the nineteen residues gH625 peptide, previously identified as a membrane-perturbing domain in the gH glycoprotein of Herpes simplex virus type I, have been prepared in order to improve the intracellular uptake of an encapsulated drug. An easy and versatile synthetic strategy, based on click chemistry, has been used to bind, in a controlled way, several copies of the hydrophobic gH625 peptide on the external surface of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPG)-based liposomes. Electron paramagnetic resonance studies, on liposomes derivatized with gH625 peptides, which are modified with the 2,2,6,6-tetramethylpiperidine-1-oxyl-4-amino-4- carboxylic acid (TOAC) spin label in several peptide positions, confirm the positioning of the coupled peptides on the liposome external surface, whereas dynamic light scattering measurements indicate an increase of the diameter of the liposomes of approximately 30-% after peptide introduction. Liposomes have been loaded with the cytotoxic drug doxorubicin and their ability to penetrate inside cells has been evaluated by confocal microscopy experiments. Results suggest that liposomes functionalized with gH625 may act as promising intracellular targeting carriers for efficient delivery of drugs, such as chemotherapeutic agents, into tumor cells. Clickable liposomes for drug delivery: Liposomes, externally modified by click chemistry with the Herpes simplex virus type I derived peptide gH625 for improving cellular uptake of encapsulated drugs, are presented in this study (see picture). The results suggest that the functionalized liposomes may act as promising intracellular targeting carriers for efficient delivery of drugs, such as chemotherapeutic agents, into tumor cells. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Clickable functionalization of liposomes with the gH625 peptide from herpes simplex virus type i for intracellular drug delivery
Clickable functionalization of liposomes with the gH625 peptide from herpes simplex virus type i for intracellular drug delivery
Other filter: ([btitle,keywords] "Click Chemistry" OR ...
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Impact Factor: 2.368
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Martínez-fernández L, Granucci G, Pollum M, Crespo-hernández CE, Persico M, Corral I
* Decoding the Molecular Basis for the Population Mechanism of the Triplet Phototoxic Precursors in UVA Light-Activated Pyrimidine Anticancer Drugs (233 views)
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Impact Factor: 5.16
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Celentano V, Diana D, Di Salvo C, De Rosa L, Romanelli A, Fattorusso R, D'Andrea LD
* 1, 2, 3-Triazole Bridge as Conformational Constrain in beta-Hairpin Peptides: Analysis of Hydrogen-Bonded Positions (403 views)
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Impact Factor: 5.317
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Accardo A, Arena F, Gianolio E, Marasco D, Ringhieri P, Boffa C, Bardini P, Aime S, Morelli G
* Diolein based nanostructures as targeted theranostics (414 views)
J Biomed Nanotechnol (ISSN: 1550-7033), 2016; 12(5): 1076-1088.
Impact Factor: 4.521
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Ringhieri P, Pannunzio A, Boccarelli A, Morelli G, Coluccia M, Tesauro D
* Effect of cisplatin containing liposomes formulated by unsaturated chain-containing lipids on gynecological tumor cells (265 views)
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Impact Factor: 1.971
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Ringhieri P, Avitabile C, Saviano M, Morelli G, Romanelli A, Accardo A
* The influence of liposomal formulation on the incorporation and retention of PNA oligomers (156 views)
Colloid Surface B (ISSN: 0927-7765), 2016; 145: 462-469.
Impact Factor: 3.887
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Vincenzi M, Accardo A, Costantini S, Scala S, Portella L, Trotta A, Ronga L, Guillon J, Leone M, Colonna G, Rossi F, Tesauro D
* Intrinsically disordered amphiphilic peptides as potential targets in drug delivery vehicles (375 views)
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Impact Factor: 2.829
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Calce E, Monfregola L, Saviano M, De Luca S
* HER2-mediated anticancer drug delivery: strategies to prepare targeting ligands highly specific for the receptor (535 views)
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Impact Factor: 3.455
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Galdiero S, Falanga A, Morelli G, Galdiero M
* gH625: A milestone in understanding the many roles of membranotropic peptides (477 views)
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Impact Factor: 5.158
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Roviello GN, Musumeci D, Roviello V
* Cationic peptides as RNA compaction agents: A study on the polyA compaction activity of a linear alpha, epsilon-oligo-l-lysine (460 views)
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Impact Factor: 3.994
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Nardon C, Boscutti G, Dalla Via L, Ringhieri P, Di Noto V, Morelli G, Accardo A, Fregona D
* CCK8 peptide-labeled Pluronic® F127 micelles as a targeted vehicle of gold-based anticancer chemotherapeutics (363 views)
Medchemcomm (ISSN: 2040-2503), 2015; 6(1): 155-163.
Impact Factor: 2.319
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Avitabile C, Accardo A, Ringhieri P, Morelli G, Saviano M, Montagner G, Fabbri E, Gallerani E, Gambari R, Romanelli A
* Incorporation of Naked Peptide Nucleic Acids into Liposomes Leads to Fast and Efficient Delivery (418 views)
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Impact Factor: 4.5
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Ringhieri P, Diaferia C, Galdiero S, Palumbo R, Morelli G, Accardo A
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Impact Factor: 1.951
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Ringhieri P, Iannitti R, Nardon C, Palumbo R, Fregona D, Morelli G, Accardo A
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Impact Factor: 3.65
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Capasso D, De Paola I, Liguoro A, Del Gatto A, Di Gaetano S, Guarnieri D, Saviano M, Zaccaro L
* Rgdechi-Hcit: Alpha V Beta 3 Selective Pro-Apoptotic Peptide As Potential Carrier For Drug Delivery Into Melanoma Metastatic Cells (428 views)
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Impact Factor: 3.234
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Oliveri V, Attanasio F, Puglisi A, Spencer J, Sgarlata C, Vecchio G
* Multifunctional 8-hydroxyquinoline-appended cyclodextrins as new inhibitors of metal-induced protein aggregation (535 views)
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Impact Factor: 5.731
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Galdiero S, Falanga A, Vitiello M, Grieco P, Caraglia M, Morelli G, Galdiero M
* Exploitation of viral properties for intracellular delivery (461 views)
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Impact Factor: 1.546
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Accardo A, Ringhieri P, Szekely N, Pipich V, Luchini A, Paduano L, Tesauro D
* Structural insights on nanoparticles containing gadolinium complexes as potential theranostic (406 views)
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Impact Factor: 1.865
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Accardo A, Aloj L, Aurilio M, Morelli G, Tesauro D
* Receptor binding peptides for target-selective delivery of nanoparticles encapsulated drugs (527 views)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1176-9114linking), 2014 Mar 27; 9(1): 1537-1557.
Impact Factor: 4.383
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Roviello GN, Roviello GN, Musumeci D, Capasso D, Di Gaetano S, Costanzo M, Pedone C
* Synthesis and supramolecular assembly of 1, 3-bis(1 '-uracilyl)-2-propanone (367 views)
Rsc Adv (ISSN: 2046-2069), 2014; 4(54): 28691-28698.
Impact Factor: 3.84
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Alterio V, Pan P, Parkkila S, Buonanno M, Supuran CT, Monti SM, De Simone G
* The Structural Comparison Between Membrane-Associated Human Carbonic Anhydrases Provides Insights Into Drug Design Of Selective Inhibitors (384 views)
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Impact Factor: 2.385
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Clemente F, Arpaia P, Manna C
* Characterization of human skin impedance after electrical treatment for transdermal drug delivery (349 views)
Measurement (ISSN: 0263-2241), 2013 Nov; 46(9): 3494-3501.
Impact Factor: 1.526
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Galdiero S, Falanga A, Cantisani M, Vitiello M, Morelli G, Galdiero M
* Peptide-Lipid Interactions: Experiments and Applications (880 views)
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Impact Factor: 2.339
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Nande R, Greco A, Gossman MS, Lopez JP, Claudio L, Salvatore M, Brunetti A, Denvir J, Howard CM, Claudio PP
* Microbubble-assisted p53, RB, and p130 gene transfer in combination with radiation therapy in prostate cancer (426 views)
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Impact Factor: 4.906
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Falciani C, Brunetti J, Lelli B, Accardo A, Tesauro D, Morelli G, Bracci L
* Nanoparticles exposing neurotensin tumor-specific drivers (403 views)
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Impact Factor: 1.862
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Accardo A, Mangiapia G, Paduano L, Morelli G, Tesauro D
* Octreotide labeled aggregates containing platinum complexes as nanovectors for drug delivery (371 views)
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Impact Factor: 1.862
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Calce E, Monfregola L, Sandomenico A, Saviano M, De Luca S
* Fluorescence study for selecting specific ligands toward HER2 receptor: An example of receptor fragment approach (402 views)
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Impact Factor: 3.432
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Travaglia A, Satriano C, Giuffrida ML, La Mendola D, Rampazzo E, Prodi L, Rizzarelli E
* Electrostatically driven interaction of silica-supported lipid bilayer nanoplatforms and a nerve growth factor-mimicking peptide (302 views)
Soft Matter (ISSN: 1744-683x), 2013; 9(18): 4648-4654.
Impact Factor: 4.151
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Smaldone G, Falanga A, Capasso D, Guarnieri D, Correale S, Galdiero M, Netti PA, Zollo M, Galdiero S, Di Gaetano S, Pedone E
* gH625 is a viral derived peptide for effective delivery of intrinsically disordered proteins (413 views)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1178-2013electronic), 2013; 8: 2555-2565.
Impact Factor: 4.195
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Accardo A, Ringhieri P, Tesauro D, Morelli G
* Liposomes derivatized with tetrabranched neurotensin peptides via click chemistry reactions (365 views)
New J Chem (ISSN: 1144-0546), 2013; 37(11): 3528-3534.
Impact Factor: 3.159
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Berisio R
* Learning from pathogens: Exploiting host-pathogen liaison for therapeutic development (362 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2012 Dec; 13(8): 697-698.
Impact Factor: 2.326
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Accardo A, Mansi R, Salzano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Ziaco B, Tesauro D, Aloj L, De Rosa G, Morelli G
* Bombesin peptide antagonist for target-selective delivery of liposomal doxorubicin on cancer cells (378 views)
Journal Of Drug Targeting (ISSN: 1061-186x), 2012 Nov 21; 21(3): 240-249.
Impact Factor: 2.768
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Roviello GN, Roviello G, Musumeci D, Bucci EM, Pedone C
* Dakin-West reaction on 1-thyminyl acetic acid for the synthesis of 1, 3-bis(1-thyminyl)-2-propanone, a heteroaromatic compound with nucleopeptide-binding properties (395 views)
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Impact Factor: 3.914
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Galdiero S, Vitiello M, Falanga A, Cantisani M, Incoronato N, Galdiero M
* Intracellular Delivery: Exploiting Viral Membranotropic Peptides (641 views)
Current Drug Metabolism (ISSN: 1389-2002), 2012 Jan; 13(1): 93-104.
Impact Factor: 4.405
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Accardo A, Salsano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Tesauro D, Aloj L, De Rosa G, Morelli G
* Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells: A potential theranostic agent (347 views)
Int J Nanomed (ISSN: 1176-9114, 1178-2013, 1178-2013electronic), 2012; 7: 2007-2017.
Impact Factor: 3.463
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Falanga A, Vitiello MT, Cantisani M, Tarallo R, Guarnieri D, Mignogna E, Netti P, Pedone C, Galdiero M, Galdiero S
* A peptide derived from herpes simplex virus type 1 glycoprotein H: membrane translocation and applications to the delivery of quantum dots (800 views)
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Impact Factor: 6.692
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Falciani C, Accardo A, Brunetti J, Tesauro D, Lelli B, Pini A, Bracci L, Morelli G
* Target-Selective Drug Delivery through Liposomes Labeled with Oligobranched Neurotensin Peptides (510 views)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2011 Apr 4; 6(4): 678-685.
Impact Factor: 3.151
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Accardo A, Morisco A, Tesauro D, Pedone C, Morelli G
* Naposomes: A new class of peptide-derivatized, target-selective multimodal nanoparticles for imaging and therapeutic applications (395 views)
Ther Deliv (ISSN: 2041-5990), 2011 Feb; 2(2): 235-257.
Impact Factor: 0
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Morisco A, Accardo A, Tesauro D, Palumbo R, Benedetti E, Morelli G
* Peptide-labeled supramolecular aggregates as selective doxorubicin carriers for delivery to tumor cells (349 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2011; 96(1): 88-96.
Impact Factor: 2.87
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Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment: Challenges and perspectives (567 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 249-258.
Impact Factor: 1.724
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Moccia M, Musumeci D, Roviello GN, Fusco S, Valente M, Bucci EM, Sapio R, Pedonea C, Netti PA
* Preliminary studies on noncovalent hyperbranched polymers based on PNA and DNA building blocks (593 views)
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Impact Factor: 1.807
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Zaccaro L, Del Gatto A, Pedone C, Saviano M
* Peptides for tumour therapy and diagnosis: current status and future directions (874 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2009 Mar; 16(7): 780-795.
Impact Factor: 4.708
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Accardo A, Tesauro D, Morelli G, Del Pozzo L, Pedone C, Tornesello AL, Benedetti E
* Supramolecular aggregates derivatized by CCK8 peptide as selective nanocarriers for drug delivery (340 views)
Adv Exp Med Biol (ISSN: 0065-2598, 0065-2598print), 2009; 611: 603-604.
Impact Factor: 2.02
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Marasco D, Perretta G, Sabatella M, Ruvo M
* Past and Future Perspectives of Synthetic Peptide Libraries (508 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2008 Oct; 9(5): 447-467.
Impact Factor: 3.011
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Accardo A, Tesauro D, Aloj L, Tarallo L, Arra C, Mangiapia G, Vaccaro M, Pedone C, Paduano L, Morelli G
* Peptide-containing aggregates as selective nanocarriers for therapeutics (360 views)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2008 Apr; 3(4): 594-602.
Impact Factor: 3.15
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Zeni O, Palumbo R, Bernini R, Zeni L, Sarti M, Scarfi MR
* Cytotoxicity investigation on cultured human blood cells treated with single-wall carbon nanotubes (293 views)
Sensors (ISSN: 1424-3210, 1424-8220, 1424-8220electronic), 2008 Jan; 8(1): 488-499.
Impact Factor: 1.87
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Maggi A, Salvatore M
Molecular imaging (315 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 95-95.
Impact Factor: 1.724
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Del Vecchio S, Zannetti A, Fonti R, Pace L, Salvatore M
* Nuclear imaging in cancer theranostics (582 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 152-163.
Impact Factor: 1.724
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Accardo A, Tesauro D, Mangiapia G, Pedone C, Morelli G
* Nanostructures by self-assembling peptide amphiphile as potential selective drug carriers (412 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2007; 88(2): 115-121.
Impact Factor: 2.389
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Pappalardo M, Milardi D, Grasso D, La Rosa C
* Phase behaviour of polymer-grafted DPPC membranes for drug delivery systems design (294 views)
Journal Of Thermal Analysis And Calorimetry (ISSN: 1388-6150), 2005 May; 80(2): 413-418.
Impact Factor: 1.425
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Cortesi R, Mischiati C, Borgatti M, Breda L, Romanelli A, Saviano M, Pedone C, Gambari R, Nastruzzi C
* Formulations for natural and peptide nucleic acids based on cationic polymeric submicron particles (369 views)
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Impact Factor: 1.938
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Borgatti M, Breda L, Cortesi R, Nastruzzi C, Romanelli A, Saviano M, Bianchi N, Mischiati C, Pedone C, Gambari R
* Cationic Liposomes As Delivery Systems For Double-Stranded Pna-Dna Chimeras Exhibiting Decoy Activity Against Nf-Kappab Transcription Factors (391 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 1873-2968, 0006-2952), 2002 Sep 15; 64(4): 609-616.
Impact Factor: 3.542
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* Human Serum Albumin Nanoparticles as a Carrier for On-Demand Sorafenib Delivery (11 views)
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Impact Factor: 2.097
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Doti N, Mardirossian M, Sandomenico A, Ruvo M, Caporale A
* Recent Applications of Retro-Inverso Peptides (15 views)
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Impact Factor: 4.556
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Agnello L, Tortorella S, D’argenio A, Carbone C, Camorani S, Locatelli E, Auletta L, Sorrentino D, Fedele M, Zannetti A, Franchini MC, Cerchia L
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Impact Factor: 11.161
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Monti A, Sturlese M, Caporale A, Roger JA, Mascanzoni F, Ruvo M, Doti N
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Impact Factor: 3.422
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Roviello GN
* Novel insights into nucleoamino acids: biomolecular recognition and aggregation studies of a thymine-conjugated L-phenyl alanine (366 views)
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Impact Factor: 3.173
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Honarvar H, Calce E, Doti N, Langella E, Orlova A, Buijs J, D’amato V, Bianco R, Saviano M, Tolmachev V, De Luca S
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Impact Factor: 4.259
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Riccardi C, Musumeci D, Capuozzo A, Irace C, King S, Russo Krauss I, Paduano L, Montesarchio D
* "dressing up" an Old Drug: An Aminoacyl Lipid for the Functionalization of Ru(III)-Based Anticancer Agents (183 views)
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Impact Factor: 0
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Chino M, Leone L, Maglio O, D'Alonzo D, Pirro F, Pavone V, Nastri F, Lombardi A
* A De Novo Heterodimeric Due Ferri Protein Minimizes the Release of Reactive Intermediates in Dioxygen-Dependent Oxidation (225 views) (PDF 167 views)
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Impact Factor: 12.102
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Marchiori MF, Riul TB, Oliveira Bortot L, Andrade P, Junqueira GG, Foca G, Doti N, Ruvo M, Dias-baruffi M, Carvalho I, Campo VL
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Impact Factor: 2.881
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Caraci F, Bruno V, Copani A, Matrisciano F, Nicoletti F, Battaglia G
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Impact Factor: 5.012
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Greco A, Albanese S, Auletta L, De Carlo F, Salvatore M, Howard CM, Claudio PP
* Advances in molecular preclinical therapy mediated by imaging (253 views) (PDF 204 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1827-1936), 2017 Mar; 61(1): 76-94.
Impact Factor: 2.368
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Martínez-fernández L, Granucci G, Pollum M, Crespo-hernández CE, Persico M, Corral I
* Decoding the Molecular Basis for the Population Mechanism of the Triplet Phototoxic Precursors in UVA Light-Activated Pyrimidine Anticancer Drugs (233 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2017; 23(11): 2619-2627.
Impact Factor: 5.16
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Celentano V, Diana D, Di Salvo C, De Rosa L, Romanelli A, Fattorusso R, D'Andrea LD
* 1, 2, 3-Triazole Bridge as Conformational Constrain in beta-Hairpin Peptides: Analysis of Hydrogen-Bonded Positions (403 views)
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Impact Factor: 5.317
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Accardo A, Arena F, Gianolio E, Marasco D, Ringhieri P, Boffa C, Bardini P, Aime S, Morelli G
* Diolein based nanostructures as targeted theranostics (414 views)
J Biomed Nanotechnol (ISSN: 1550-7033), 2016; 12(5): 1076-1088.
Impact Factor: 4.521
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Ringhieri P, Pannunzio A, Boccarelli A, Morelli G, Coluccia M, Tesauro D
* Effect of cisplatin containing liposomes formulated by unsaturated chain-containing lipids on gynecological tumor cells (265 views)
J Liposome Res (ISSN: 0898-2104), 2016; N/D: 1-6.
Impact Factor: 1.971
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Ringhieri P, Avitabile C, Saviano M, Morelli G, Romanelli A, Accardo A
* The influence of liposomal formulation on the incorporation and retention of PNA oligomers (156 views)
Colloid Surface B (ISSN: 0927-7765), 2016; 145: 462-469.
Impact Factor: 3.887
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Vincenzi M, Accardo A, Costantini S, Scala S, Portella L, Trotta A, Ronga L, Guillon J, Leone M, Colonna G, Rossi F, Tesauro D
* Intrinsically disordered amphiphilic peptides as potential targets in drug delivery vehicles (375 views)
Mol Biosyst (ISSN: 1742-206x), 2015 Oct 13; 11(11): 2925-2932.
Impact Factor: 2.829
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Calce E, Monfregola L, Saviano M, De Luca S
* HER2-mediated anticancer drug delivery: strategies to prepare targeting ligands highly specific for the receptor (535 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2015 May 20; 22(21): 2525-2538.
Impact Factor: 3.455
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Galdiero S, Falanga A, Morelli G, Galdiero M
* gH625: A milestone in understanding the many roles of membranotropic peptides (477 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2015 Jan; 1848(PA): 16-25.
Impact Factor: 5.158
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Roviello GN, Musumeci D, Roviello V
* Cationic peptides as RNA compaction agents: A study on the polyA compaction activity of a linear alpha, epsilon-oligo-l-lysine (460 views)
Int J Pharm (ISSN: 0378-5173, 1873-3476), 2015; 485(1-2): 244-248.
Impact Factor: 3.994
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Nardon C, Boscutti G, Dalla Via L, Ringhieri P, Di Noto V, Morelli G, Accardo A, Fregona D
* CCK8 peptide-labeled Pluronic® F127 micelles as a targeted vehicle of gold-based anticancer chemotherapeutics (363 views)
Medchemcomm (ISSN: 2040-2503), 2015; 6(1): 155-163.
Impact Factor: 2.319
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Avitabile C, Accardo A, Ringhieri P, Morelli G, Saviano M, Montagner G, Fabbri E, Gallerani E, Gambari R, Romanelli A
* Incorporation of Naked Peptide Nucleic Acids into Liposomes Leads to Fast and Efficient Delivery (418 views)
Bioconjug Chem (ISSN: 1043-1802, 1520-4812), 2015; 26(8): 1533-1541.
Impact Factor: 4.5
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Ringhieri P, Diaferia C, Galdiero S, Palumbo R, Morelli G, Accardo A
* Liposomal doxorubicin doubly functionalized with CCK8 and R8 peptide sequences for selective intracellular drug delivery (429 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617linking), 2015; 21(5): 415-425.
Impact Factor: 1.951
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Ringhieri P, Iannitti R, Nardon C, Palumbo R, Fregona D, Morelli G, Accardo A
* Target selective micelles for bombesin receptors incorporating Au(III)-dithiocarbamato complexes (368 views)
Int J Pharm (ISSN: 0378-5173, 1873-3476), 2014 Oct 1; 473(1-2): 194-202.
Impact Factor: 3.65
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Capasso D, De Paola I, Liguoro A, Del Gatto A, Di Gaetano S, Guarnieri D, Saviano M, Zaccaro L
* Rgdechi-Hcit: Alpha V Beta 3 Selective Pro-Apoptotic Peptide As Potential Carrier For Drug Delivery Into Melanoma Metastatic Cells (428 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2014 Sep 23; 9(9): e106441-e106441.
Impact Factor: 3.234
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Oliveri V, Attanasio F, Puglisi A, Spencer J, Sgarlata C, Vecchio G
* Multifunctional 8-hydroxyquinoline-appended cyclodextrins as new inhibitors of metal-induced protein aggregation (535 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2014 Jul 14; 20(29): 8954-8964.
Impact Factor: 5.731
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Galdiero S, Falanga A, Vitiello M, Grieco P, Caraglia M, Morelli G, Galdiero M
* Exploitation of viral properties for intracellular delivery (461 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617linking), 2014 Jul; 20(7): 468-478.
Impact Factor: 1.546
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Accardo A, Ringhieri P, Szekely N, Pipich V, Luchini A, Paduano L, Tesauro D
* Structural insights on nanoparticles containing gadolinium complexes as potential theranostic (406 views)
Colloid Polym Sci (ISSN: 0303-402x), 2014 May; 292(5): 1121-1127.
Impact Factor: 1.865
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Accardo A, Aloj L, Aurilio M, Morelli G, Tesauro D
* Receptor binding peptides for target-selective delivery of nanoparticles encapsulated drugs (527 views)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1176-9114linking), 2014 Mar 27; 9(1): 1537-1557.
Impact Factor: 4.383
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Roviello GN, Roviello GN, Musumeci D, Capasso D, Di Gaetano S, Costanzo M, Pedone C
* Synthesis and supramolecular assembly of 1, 3-bis(1 '-uracilyl)-2-propanone (367 views)
Rsc Adv (ISSN: 2046-2069), 2014; 4(54): 28691-28698.
Impact Factor: 3.84
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Alterio V, Pan P, Parkkila S, Buonanno M, Supuran CT, Monti SM, De Simone G
* The Structural Comparison Between Membrane-Associated Human Carbonic Anhydrases Provides Insights Into Drug Design Of Selective Inhibitors (384 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2014; 101(7): 769-778.
Impact Factor: 2.385
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Clemente F, Arpaia P, Manna C
* Characterization of human skin impedance after electrical treatment for transdermal drug delivery (349 views)
Measurement (ISSN: 0263-2241), 2013 Nov; 46(9): 3494-3501.
Impact Factor: 1.526
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Galdiero S, Falanga A, Cantisani M, Vitiello M, Morelli G, Galdiero M
* Peptide-Lipid Interactions: Experiments and Applications (880 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067electronic), 2013 Sep; 14(9): 18758-18789.
Impact Factor: 2.339
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Nande R, Greco A, Gossman MS, Lopez JP, Claudio L, Salvatore M, Brunetti A, Denvir J, Howard CM, Claudio PP
* Microbubble-assisted p53, RB, and p130 gene transfer in combination with radiation therapy in prostate cancer (426 views)
Current Gene Therapy (ISSN: 1875-5631, 1566-5232), 2013 Jun 1; 13(3): 163-174.
Impact Factor: 4.906
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Falciani C, Brunetti J, Lelli B, Accardo A, Tesauro D, Morelli G, Bracci L
* Nanoparticles exposing neurotensin tumor-specific drivers (403 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Apr; 19(4): 198-204.
Impact Factor: 1.862
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Accardo A, Mangiapia G, Paduano L, Morelli G, Tesauro D
* Octreotide labeled aggregates containing platinum complexes as nanovectors for drug delivery (371 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Apr; 19(4): 190-197.
Impact Factor: 1.862
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Calce E, Monfregola L, Sandomenico A, Saviano M, De Luca S
* Fluorescence study for selecting specific ligands toward HER2 receptor: An example of receptor fragment approach (402 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2013 Mar; 61: 116-121.
Impact Factor: 3.432
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Travaglia A, Satriano C, Giuffrida ML, La Mendola D, Rampazzo E, Prodi L, Rizzarelli E
* Electrostatically driven interaction of silica-supported lipid bilayer nanoplatforms and a nerve growth factor-mimicking peptide (302 views)
Soft Matter (ISSN: 1744-683x), 2013; 9(18): 4648-4654.
Impact Factor: 4.151
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Smaldone G, Falanga A, Capasso D, Guarnieri D, Correale S, Galdiero M, Netti PA, Zollo M, Galdiero S, Di Gaetano S, Pedone E
* gH625 is a viral derived peptide for effective delivery of intrinsically disordered proteins (413 views)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1178-2013electronic), 2013; 8: 2555-2565.
Impact Factor: 4.195
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Accardo A, Ringhieri P, Tesauro D, Morelli G
* Liposomes derivatized with tetrabranched neurotensin peptides via click chemistry reactions (365 views)
New J Chem (ISSN: 1144-0546), 2013; 37(11): 3528-3534.
Impact Factor: 3.159
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Berisio R
* Learning from pathogens: Exploiting host-pathogen liaison for therapeutic development (362 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2012 Dec; 13(8): 697-698.
Impact Factor: 2.326
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Accardo A, Mansi R, Salzano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Ziaco B, Tesauro D, Aloj L, De Rosa G, Morelli G
* Bombesin peptide antagonist for target-selective delivery of liposomal doxorubicin on cancer cells (378 views)
Journal Of Drug Targeting (ISSN: 1061-186x), 2012 Nov 21; 21(3): 240-249.
Impact Factor: 2.768
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Roviello GN, Roviello G, Musumeci D, Bucci EM, Pedone C
* Dakin-West reaction on 1-thyminyl acetic acid for the synthesis of 1, 3-bis(1-thyminyl)-2-propanone, a heteroaromatic compound with nucleopeptide-binding properties (395 views)
Amino Acids (ISSN: 1438-2199, 0939-4451, 1438-2199electronic), 2012 Oct; 43(4): 1615-1623.
Impact Factor: 3.914
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Galdiero S, Vitiello M, Falanga A, Cantisani M, Incoronato N, Galdiero M
* Intracellular Delivery: Exploiting Viral Membranotropic Peptides (641 views)
Current Drug Metabolism (ISSN: 1389-2002), 2012 Jan; 13(1): 93-104.
Impact Factor: 4.405
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Accardo A, Salsano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Tesauro D, Aloj L, De Rosa G, Morelli G
* Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells: A potential theranostic agent (347 views)
Int J Nanomed (ISSN: 1176-9114, 1178-2013, 1178-2013electronic), 2012; 7: 2007-2017.
Impact Factor: 3.463
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Falanga A, Vitiello MT, Cantisani M, Tarallo R, Guarnieri D, Mignogna E, Netti P, Pedone C, Galdiero M, Galdiero S
* A peptide derived from herpes simplex virus type 1 glycoprotein H: membrane translocation and applications to the delivery of quantum dots (800 views)
Nanomedicine (ISSN: 1549-9642, 1549-9634, 1549-9642electronic), 2011 Dec; 7(6): 925-934.
Impact Factor: 6.692
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Falciani C, Accardo A, Brunetti J, Tesauro D, Lelli B, Pini A, Bracci L, Morelli G
* Target-Selective Drug Delivery through Liposomes Labeled with Oligobranched Neurotensin Peptides (510 views)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2011 Apr 4; 6(4): 678-685.
Impact Factor: 3.151
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Accardo A, Morisco A, Tesauro D, Pedone C, Morelli G
* Naposomes: A new class of peptide-derivatized, target-selective multimodal nanoparticles for imaging and therapeutic applications (395 views)
Ther Deliv (ISSN: 2041-5990), 2011 Feb; 2(2): 235-257.
Impact Factor: 0
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Morisco A, Accardo A, Tesauro D, Palumbo R, Benedetti E, Morelli G
* Peptide-labeled supramolecular aggregates as selective doxorubicin carriers for delivery to tumor cells (349 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2011; 96(1): 88-96.
Impact Factor: 2.87
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Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment: Challenges and perspectives (567 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 249-258.
Impact Factor: 1.724
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Moccia M, Musumeci D, Roviello GN, Fusco S, Valente M, Bucci EM, Sapio R, Pedonea C, Netti PA
* Preliminary studies on noncovalent hyperbranched polymers based on PNA and DNA building blocks (593 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Oct; 15(10): 647-653.
Impact Factor: 1.807
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Zaccaro L, Del Gatto A, Pedone C, Saviano M
* Peptides for tumour therapy and diagnosis: current status and future directions (874 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2009 Mar; 16(7): 780-795.
Impact Factor: 4.708
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Accardo A, Tesauro D, Morelli G, Del Pozzo L, Pedone C, Tornesello AL, Benedetti E
* Supramolecular aggregates derivatized by CCK8 peptide as selective nanocarriers for drug delivery (340 views)
Adv Exp Med Biol (ISSN: 0065-2598, 0065-2598print), 2009; 611: 603-604.
Impact Factor: 2.02
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Marasco D, Perretta G, Sabatella M, Ruvo M
* Past and Future Perspectives of Synthetic Peptide Libraries (508 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2008 Oct; 9(5): 447-467.
Impact Factor: 3.011
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Accardo A, Tesauro D, Aloj L, Tarallo L, Arra C, Mangiapia G, Vaccaro M, Pedone C, Paduano L, Morelli G
* Peptide-containing aggregates as selective nanocarriers for therapeutics (360 views)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2008 Apr; 3(4): 594-602.
Impact Factor: 3.15
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Zeni O, Palumbo R, Bernini R, Zeni L, Sarti M, Scarfi MR
* Cytotoxicity investigation on cultured human blood cells treated with single-wall carbon nanotubes (293 views)
Sensors (ISSN: 1424-3210, 1424-8220, 1424-8220electronic), 2008 Jan; 8(1): 488-499.
Impact Factor: 1.87
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Maggi A, Salvatore M
Molecular imaging (315 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 95-95.
Impact Factor: 1.724
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Del Vecchio S, Zannetti A, Fonti R, Pace L, Salvatore M
* Nuclear imaging in cancer theranostics (582 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 152-163.
Impact Factor: 1.724
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Accardo A, Tesauro D, Mangiapia G, Pedone C, Morelli G
* Nanostructures by self-assembling peptide amphiphile as potential selective drug carriers (412 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2007; 88(2): 115-121.
Impact Factor: 2.389
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Pappalardo M, Milardi D, Grasso D, La Rosa C
* Phase behaviour of polymer-grafted DPPC membranes for drug delivery systems design (294 views)
Journal Of Thermal Analysis And Calorimetry (ISSN: 1388-6150), 2005 May; 80(2): 413-418.
Impact Factor: 1.425
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Cortesi R, Mischiati C, Borgatti M, Breda L, Romanelli A, Saviano M, Pedone C, Gambari R, Nastruzzi C
* Formulations for natural and peptide nucleic acids based on cationic polymeric submicron particles (369 views)
The Aaps Journal (ISSN: 1522-1059, 1550-7416), 2004 Jan 20; 6(1): N/D-N/D.
Impact Factor: 1.938
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Borgatti M, Breda L, Cortesi R, Nastruzzi C, Romanelli A, Saviano M, Bianchi N, Mischiati C, Pedone C, Gambari R
* Cationic Liposomes As Delivery Systems For Double-Stranded Pna-Dna Chimeras Exhibiting Decoy Activity Against Nf-Kappab Transcription Factors (391 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 1873-2968, 0006-2952), 2002 Sep 15; 64(4): 609-616.
Impact Factor: 3.542
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62 Records (58 excluding Abstracts).
Total impact factor: 210.78 (199.625 excluding Abstracts).
Total 5 year impact factor: 212.355 (196.884 excluding Abstracts).
Total impact factor: 210.78 (199.625 excluding Abstracts).
Total 5 year impact factor: 212.355 (196.884 excluding Abstracts).
437 views. Last view on Monday 18 July 2022, 6:57:43
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