A randomized controlled clinical trial of growth hormone in amyotrophic lateral sclerosis: clinical, neuroimaging, and hormonal results (757 views)
J Neurol (ISSN: 1432-1459, 0340-5354, 1432-1459electronic), 2012 Jan; 259(1): 132-138.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Clinical Trial, Phase Ii, Randomized Controlled Trial, Research Support, Non-U. S. Gov'T,
Impact factor: 3.578, 5-year impact factor: 3.598
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84856701376&partnerID=40&md5=9adf7ccdcb1d74076ea7dad4ceb8723a
Keywords: Amyotrophic Lateral Sclerosis, Growth Hormone, Homa-Ir, Igf-I, Igfbp-3, Insulin, Arginine, Choline, Creatine, Gonadorelin, Human Growth Hormone, N Acetylaspartic Acid, Placebo, Riluzole, Somatomedin Binding Protein 3, Adult, Aged, Amyotrophic Lateral Sclerosis Functional Rating Scale Revised, Clinical Article, Controlled Study, Disease Course, Disease Duration, Disease Severity, Double Blind Procedure, Drug Dose Increase, Female, Glucose Blood Level, Growth Hormone Deficiency, Hormone Determination, Hypertension, Injection Site Reaction, Insulin Resistance, Joint Stiffness, Joint Swelling, Limb Weakness, Mortality, Motor Cortex, Motor Performance, Neuroimaging, Nuclear Magnetic Resonance Spectroscopy, Peripheral Edema, Phase 2 Clinical Trial, Priority Journal, Randomized Controlled Trial, Side Effect, 80 And Over, Double-Blind Method, Endpoint Determination, Image Processing, Computer-Assisted, Insulin-Like Growth Factor Binding Protein 3, Magnetic Resonance Imaging, Middle Aged, Neuroprotective Agents, Recombinant Proteins,
Affiliations:
*** IBB - CNR ***
Department of Neurological Sciences, University Federico II, Via Pansini, 5, 80131 Naples, NA, Italy. francesco.sacca@unina.it
Biostructure and Bioimaging Institute, National Research Council, Naples, Italy
U.O.C. Neurofisiopatologia, PO S. Gennaro ASL Napoli 1, Naples, Italy
U. O. C. Neurofisiopatologia, PO S. Gennaro ASL Napoli 1, Naples, Italy
References:
Bensimon, G., Lacomblez, L., Meininger, V., A controlled trial of riluzole in amyotrophic lateral sclerosis (1994) New England Journal of Medicine, 330 (9), pp. 585-591. , DOI 10.1056/NEJM19940303330090
Morselli, L.L., Bongioanni, P., Genovesi, M., Growth hormone secretion is impaired in amyotrophic lateral sclerosis (2006) Clin Endocrinol (Oxf), 65, pp. 385-388. , 10.1111/j.1365-2265.2006.02609.x 1:CAS:528:DC%2BD28XhtVOqtLjK
Lai, E.C., Felice, K.J., Festoff, B.W., Gawel, M.J., Gelinas, D.F., Kratz, R., Murphy, M.F., Rudnicki, S.A., Effect of recombinant human insulin-like growth factor-I on progression of ALS: A placebo-controlled study (1997) Neurology, 49 (6), pp. 1621-1630
Borasio, G.D., Robberecht, W., Leigh, P.N., Emile, J., Guiloff, R.J., Jerusalem, F., Silani, V., Dobbins, T., A placebo-controlled trial of insulin-like growth factor-I in amyotrophic lateral sclerosis (1998) Neurology, 51 (2), pp. 583-586
Sorenson, E.J., Windbank, A.J., Mandrekar, J.N., Subcutaneous IGF-1 is not beneficial in 2-year ALS trial (2008) Neurology, 71, pp. 1770-1775. , 19029516 10.1212/01.wnl.0000335970.78664.36 1:CAS:528:DC%2BD1cXhtlylurjK
Smith, R.A., Melmed, S., Sherman, B., Frane, J., Munsat, T.L., Festoff, B.W., Recombinant growth hormone treatment of amyotrophic lateral sclerosis (1993) Muscle and Nerve, 16 (6), pp. 624-633. , DOI 10.1002/mus.880160608
Cedarbaum, J.M., Stambler, N., Malta, E., Fuller, C., Hilt, D., Thurmond, B., Nakanishi, A., The ALSFRS-R: A revised ALS functional rating scale that incorporates assessments of respiratory function (1999) Journal of the Neurological Sciences, 169 (1-2), pp. 13-21. , DOI 10.1016/S0022-510X(99)00210-5, PII S0022510X99002105
Suhy, J., Miller, R.G., Rule, R., Schuff, N., Licht, J., Dronsky, V., Gelinas, D., Weiner, M.W., Early detection and longitudinal changes in amyotrophic lateral sclerosis by 1H MRSI (2002) Neurology, 58 (5), pp. 773-779
Matthews, D.R., Hosker, J.P., Rudenski, A.S., Homeostasis model assessment: Insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man (1985) Diabetologia, 28 (7), pp. 412-419. , DOI 10.1007/BF00280883
Aberg, N.D., Lind, J., Isgaard, J., Georg Kuhn, H., Peripheral growth hormone induces cell proliferation in the intect adult rat brain (2010) Growth Horm IGF Res, 20, pp. 264-269. , 10.1016/j.ghir.2009.12.003
Kaspar, B.K., Frost, L.M., Christian, L., Umapathi, P., Gage, F.H., Synergy of insulin-like growth factor-1 and exercise in amyotrophic lateral sclerosis (2005) Annals of Neurology, 57 (5), pp. 649-655. , DOI 10.1002/ana.20451
Kaspar, B.K., Llado, J., Sherkat, N., Rothstein, J.D., Gage, F.H., Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model (2003) Science, 301 (5634), pp. 839-842. , DOI 10.1126/science.1086137
Buckway, C.K., Guevara-Aguirre, J., Pratt, K.L., Burren, C.P., Rosenfeld, R.G., The IGF-I generation test revisited: A marker of GH sensitivity (2001) Journal of Clinical Endocrinology and Metabolism, 86 (11), pp. 5176-5183. , DOI 10.1210/jc.86.11.5176
Pellecchia, M.T., Pivonello, R., Monsurro, M.R., The GH-IGF system in amyotrophic lateral sclerosis: Correlations between pituitary GH secretion capacity, insulin-like growth factors and clinical features (2010) Eur J Neurol, 17, pp. 666-671. , 20002733 10.1111/j.1468-1331.2009.02896.x 1:STN:280: DC%2BC3czpsVKhsw%3D%3D
Salvatore, E., Rinaldi, C., Tucci, T., Growth hormone response to arginine test differentiates between two subgroups of Huntington's disease patients (2011) J Neurol Neurosurg Psychiatry, 82, pp. 543-547
Reyes, E.T., Perurena, O.H., Festoff, B.W., Insulin resistance in amyotrophic lateral sclerosis (1984) Journal of the Neurological Sciences, 63 (3), pp. 317-324. , DOI 10.1016/0022-510X(84)90154-0
Pradat, P.F., Bruneteau, G., Gordon, P.H., Impaired glucose tolerance in patients with amyotrophic lateral sclerosis (2010) Amyotroph Lateral Scler, 11, pp. 166-171. , 20184518 10.3109/17482960902822960 1:CAS:528:DC%2BC3cXisV2msbw%3D
Torres-Aleman, I., Barrios, V., Berciano, J., The peripheral insulin-like growth factor system in amyotrophic lateral sclerosis (1998) Neurology, 50, pp. 772-776. , 9521273 1:STN:280:DyaK1c7otVGluw%3D%3D
Corbo, M., Lunetta, C., Magni, P., Free insulin-like growth factor (IGF)-1 and IGF-binding proteins-2 and -3 in serum and cerebrospinal fluid of amyotrophic lateral sclerosis patients (2010) Eur J Neurol, 17, pp. 398-404. , 19845745 10.1111/j.1468-1331.2009.02815.x 1:STN:280: DC%2BC3czitlGquw%3D%3D
Hosback, S., Hardiman, O., Nolan, C.M., Doyle, M.A.C., Gorman, G., Lynch, C., O'Toole, O., Jakeman, P., Circulating insulin-like growth factors and related binding proteins are selectively altered in amyotrophic lateral sclerosis and multiple sclerosis (2007) Growth Hormone and IGF Research, 17 (6), pp. 472-479. , DOI 10.1016/j.ghir.2007.06.002, PII S109663740700086X
Olivecrona, H., Hilding, A., Ekstrom, C., Barle, H., Nyberg, B., Moller, C., Delhanty, P.J., Tally, M., Acute and short-term effects of growth hormone on insulin-like growth factors and their binding proteins: Serum levels and hepatic messenger ribonucleic acid responses in humans (1999) Journal of Clinical Endocrinology and Metabolism, 84 (2), pp. 553-560. , DOI 10.1210/jc.84.2.553
Butt, A.J., Firth, S.M., King, M.A., Baxter, R.C., Insulin-like growth factor-binding protein-3 modulates expression of Bax and Bcl-2 and potentiates p53-independent radiation-induced apoptosis in human breast cancer cells (2000) Journal of Biological Chemistry, 275 (50), pp. 39174-39181. , DOI 10.1074/jbc.M908888199
Liao, L., Dearth, R.K., Zhou, S., Britton, O.L., Lee, A.V., Xu, J., Liver-specific overexpression of the insulin-like growth factor-I enhances somatic growth and partially prevents the effects of growth hormone deficiency (2006) Endocrinology, 147 (8), pp. 3877-3888. , http://endo.endojournals.org/cgi/reprint/147/8/3877, DOI 10.1210/en.2005-1537
Niebroj-Dobosz, I., Janik, P., Soko-Çowska, B., Kwiecinski, H., Matrix metalloproteinases and their tissue inhibitors in serum and cerebrospinal fluid of patients with amyotrophic lateral sclerosis (2010) Eur J Neurol, 17, pp. 226-231. , 19796283 10.1111/j.1468-1331.2009.02775.x 1:STN:280: DC%2BC3czitlGjuw%3D%3D
Mitsui, Y., Mochizuki, S., Kodama, T., Shimoda, M., Ohtsuka, T., Shiomi, T., Chijiiwa, M., Okada, Y., ADAM28 is overexpressed in human breast carcinomas: Implications for carcinoma cell proliferation through cleavage of insulin-like growth factor binding protein-3 (2006) Cancer Research, 66 (20), pp. 9913-9920. , DOI 10.1158/0008-5472.CAN-06-0377
J Neurol (ISSN: 1432-1459, 0340-5354, 1432-1459electronic), 2012 Jan; 259(1): 132-138.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Clinical Trial, Phase Ii, Randomized Controlled Trial, Research Support, Non-U. S. Gov'T,
Impact factor: 3.578, 5-year impact factor: 3.598
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84856701376&partnerID=40&md5=9adf7ccdcb1d74076ea7dad4ceb8723a
Keywords: Amyotrophic Lateral Sclerosis, Growth Hormone, Homa-Ir, Igf-I, Igfbp-3, Insulin, Arginine, Choline, Creatine, Gonadorelin, Human Growth Hormone, N Acetylaspartic Acid, Placebo, Riluzole, Somatomedin Binding Protein 3, Adult, Aged, Amyotrophic Lateral Sclerosis Functional Rating Scale Revised, Clinical Article, Controlled Study, Disease Course, Disease Duration, Disease Severity, Double Blind Procedure, Drug Dose Increase, Female, Glucose Blood Level, Growth Hormone Deficiency, Hormone Determination, Hypertension, Injection Site Reaction, Insulin Resistance, Joint Stiffness, Joint Swelling, Limb Weakness, Mortality, Motor Cortex, Motor Performance, Neuroimaging, Nuclear Magnetic Resonance Spectroscopy, Peripheral Edema, Phase 2 Clinical Trial, Priority Journal, Randomized Controlled Trial, Side Effect, 80 And Over, Double-Blind Method, Endpoint Determination, Image Processing, Computer-Assisted, Insulin-Like Growth Factor Binding Protein 3, Magnetic Resonance Imaging, Middle Aged, Neuroprotective Agents, Recombinant Proteins,
Affiliations:
*** IBB - CNR ***
Department of Neurological Sciences, University Federico II, Via Pansini, 5, 80131 Naples, NA, Italy. francesco.sacca@unina.it
Biostructure and Bioimaging Institute, National Research Council, Naples, Italy
U.O.C. Neurofisiopatologia, PO S. Gennaro ASL Napoli 1, Naples, Italy
U. O. C. Neurofisiopatologia, PO S. Gennaro ASL Napoli 1, Naples, Italy
References:
Bensimon, G., Lacomblez, L., Meininger, V., A controlled trial of riluzole in amyotrophic lateral sclerosis (1994) New England Journal of Medicine, 330 (9), pp. 585-591. , DOI 10.1056/NEJM19940303330090
Morselli, L.L., Bongioanni, P., Genovesi, M., Growth hormone secretion is impaired in amyotrophic lateral sclerosis (2006) Clin Endocrinol (Oxf), 65, pp. 385-388. , 10.1111/j.1365-2265.2006.02609.x 1:CAS:528:DC%2BD28XhtVOqtLjK
Lai, E.C., Felice, K.J., Festoff, B.W., Gawel, M.J., Gelinas, D.F., Kratz, R., Murphy, M.F., Rudnicki, S.A., Effect of recombinant human insulin-like growth factor-I on progression of ALS: A placebo-controlled study (1997) Neurology, 49 (6), pp. 1621-1630
Borasio, G.D., Robberecht, W., Leigh, P.N., Emile, J., Guiloff, R.J., Jerusalem, F., Silani, V., Dobbins, T., A placebo-controlled trial of insulin-like growth factor-I in amyotrophic lateral sclerosis (1998) Neurology, 51 (2), pp. 583-586
Sorenson, E.J., Windbank, A.J., Mandrekar, J.N., Subcutaneous IGF-1 is not beneficial in 2-year ALS trial (2008) Neurology, 71, pp. 1770-1775. , 19029516 10.1212/01.wnl.0000335970.78664.36 1:CAS:528:DC%2BD1cXhtlylurjK
Smith, R.A., Melmed, S., Sherman, B., Frane, J., Munsat, T.L., Festoff, B.W., Recombinant growth hormone treatment of amyotrophic lateral sclerosis (1993) Muscle and Nerve, 16 (6), pp. 624-633. , DOI 10.1002/mus.880160608
Cedarbaum, J.M., Stambler, N., Malta, E., Fuller, C., Hilt, D., Thurmond, B., Nakanishi, A., The ALSFRS-R: A revised ALS functional rating scale that incorporates assessments of respiratory function (1999) Journal of the Neurological Sciences, 169 (1-2), pp. 13-21. , DOI 10.1016/S0022-510X(99)00210-5, PII S0022510X99002105
Suhy, J., Miller, R.G., Rule, R., Schuff, N., Licht, J., Dronsky, V., Gelinas, D., Weiner, M.W., Early detection and longitudinal changes in amyotrophic lateral sclerosis by 1H MRSI (2002) Neurology, 58 (5), pp. 773-779
Matthews, D.R., Hosker, J.P., Rudenski, A.S., Homeostasis model assessment: Insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man (1985) Diabetologia, 28 (7), pp. 412-419. , DOI 10.1007/BF00280883
Aberg, N.D., Lind, J., Isgaard, J., Georg Kuhn, H., Peripheral growth hormone induces cell proliferation in the intect adult rat brain (2010) Growth Horm IGF Res, 20, pp. 264-269. , 10.1016/j.ghir.2009.12.003
Kaspar, B.K., Frost, L.M., Christian, L., Umapathi, P., Gage, F.H., Synergy of insulin-like growth factor-1 and exercise in amyotrophic lateral sclerosis (2005) Annals of Neurology, 57 (5), pp. 649-655. , DOI 10.1002/ana.20451
Kaspar, B.K., Llado, J., Sherkat, N., Rothstein, J.D., Gage, F.H., Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model (2003) Science, 301 (5634), pp. 839-842. , DOI 10.1126/science.1086137
Buckway, C.K., Guevara-Aguirre, J., Pratt, K.L., Burren, C.P., Rosenfeld, R.G., The IGF-I generation test revisited: A marker of GH sensitivity (2001) Journal of Clinical Endocrinology and Metabolism, 86 (11), pp. 5176-5183. , DOI 10.1210/jc.86.11.5176
Pellecchia, M.T., Pivonello, R., Monsurro, M.R., The GH-IGF system in amyotrophic lateral sclerosis: Correlations between pituitary GH secretion capacity, insulin-like growth factors and clinical features (2010) Eur J Neurol, 17, pp. 666-671. , 20002733 10.1111/j.1468-1331.2009.02896.x 1:STN:280: DC%2BC3czpsVKhsw%3D%3D
Salvatore, E., Rinaldi, C., Tucci, T., Growth hormone response to arginine test differentiates between two subgroups of Huntington's disease patients (2011) J Neurol Neurosurg Psychiatry, 82, pp. 543-547
Reyes, E.T., Perurena, O.H., Festoff, B.W., Insulin resistance in amyotrophic lateral sclerosis (1984) Journal of the Neurological Sciences, 63 (3), pp. 317-324. , DOI 10.1016/0022-510X(84)90154-0
Pradat, P.F., Bruneteau, G., Gordon, P.H., Impaired glucose tolerance in patients with amyotrophic lateral sclerosis (2010) Amyotroph Lateral Scler, 11, pp. 166-171. , 20184518 10.3109/17482960902822960 1:CAS:528:DC%2BC3cXisV2msbw%3D
Torres-Aleman, I., Barrios, V., Berciano, J., The peripheral insulin-like growth factor system in amyotrophic lateral sclerosis (1998) Neurology, 50, pp. 772-776. , 9521273 1:STN:280:DyaK1c7otVGluw%3D%3D
Corbo, M., Lunetta, C., Magni, P., Free insulin-like growth factor (IGF)-1 and IGF-binding proteins-2 and -3 in serum and cerebrospinal fluid of amyotrophic lateral sclerosis patients (2010) Eur J Neurol, 17, pp. 398-404. , 19845745 10.1111/j.1468-1331.2009.02815.x 1:STN:280: DC%2BC3czitlGquw%3D%3D
Hosback, S., Hardiman, O., Nolan, C.M., Doyle, M.A.C., Gorman, G., Lynch, C., O'Toole, O., Jakeman, P., Circulating insulin-like growth factors and related binding proteins are selectively altered in amyotrophic lateral sclerosis and multiple sclerosis (2007) Growth Hormone and IGF Research, 17 (6), pp. 472-479. , DOI 10.1016/j.ghir.2007.06.002, PII S109663740700086X
Olivecrona, H., Hilding, A., Ekstrom, C., Barle, H., Nyberg, B., Moller, C., Delhanty, P.J., Tally, M., Acute and short-term effects of growth hormone on insulin-like growth factors and their binding proteins: Serum levels and hepatic messenger ribonucleic acid responses in humans (1999) Journal of Clinical Endocrinology and Metabolism, 84 (2), pp. 553-560. , DOI 10.1210/jc.84.2.553
Butt, A.J., Firth, S.M., King, M.A., Baxter, R.C., Insulin-like growth factor-binding protein-3 modulates expression of Bax and Bcl-2 and potentiates p53-independent radiation-induced apoptosis in human breast cancer cells (2000) Journal of Biological Chemistry, 275 (50), pp. 39174-39181. , DOI 10.1074/jbc.M908888199
Liao, L., Dearth, R.K., Zhou, S., Britton, O.L., Lee, A.V., Xu, J., Liver-specific overexpression of the insulin-like growth factor-I enhances somatic growth and partially prevents the effects of growth hormone deficiency (2006) Endocrinology, 147 (8), pp. 3877-3888. , http://endo.endojournals.org/cgi/reprint/147/8/3877, DOI 10.1210/en.2005-1537
Niebroj-Dobosz, I., Janik, P., Soko-Çowska, B., Kwiecinski, H., Matrix metalloproteinases and their tissue inhibitors in serum and cerebrospinal fluid of patients with amyotrophic lateral sclerosis (2010) Eur J Neurol, 17, pp. 226-231. , 19796283 10.1111/j.1468-1331.2009.02775.x 1:STN:280: DC%2BC3czitlGjuw%3D%3D
Mitsui, Y., Mochizuki, S., Kodama, T., Shimoda, M., Ohtsuka, T., Shiomi, T., Chijiiwa, M., Okada, Y., ADAM28 is overexpressed in human breast carcinomas: Implications for carcinoma cell proliferation through cleavage of insulin-like growth factor binding protein-3 (2006) Cancer Research, 66 (20), pp. 9913-9920. , DOI 10.1158/0008-5472.CAN-06-0377
A randomized controlled clinical trial of growth hormone in amyotrophic lateral sclerosis: clinical, neuroimaging, and hormonal results
Amyotrophic lateral sclerosis (ALS) is a fatal neurological disease with motor neuron degeneration. Riluzole is the only available treatment. Two-thirds of ALS patients present with growth hormone (GH) deficiency. The aim of this study is to determine if add-on of GH to riluzole, with an individually regulated dose based on Insulin-like growth factor 1 (IGF-I) production, was able to reduce neuronal loss in the motor cortex, reduce mortality, and improve motor function of ALS patients. Patients with definite/probable ALS, in treatment with riluzole, aged 40-85 years, and with disease duration ≥3 years were enrolled. The study was randomized, placebo controlled, and double blind. Before treatment, patients were tested with a GH releasing hormone (GHRH) + arginine test. The initial dose of GH was 2 IU s.c. every other day, and was progressively increased to a maximum of 8 IU. Primary endpoint was N-acetylaspartate/(creatine + choline) (NAA/Cre + Cho) ratio in motor cortex assessed by magnetic resonance spectroscopy performed at months 0, 6, and 12. Secondary endpoints were mortality and ALS functional rating scale revised (ALSFRS-R). The NAA/(Cre + Cho) ratio decreased in all patients who completed the trial. No significant difference was noted between treated and placebo group. At baseline, although IGF-I levels were within the normal range, 73% of patients had GH deficiency, being severe in half of them. Compared with bulbar onset, spinal-onset patients showed more depressed GH response to the GHRH + arginine stimulation test (10.4 ± 7.0 versus 15.5 ± 8.1 ng/mL; p < 0.05). Insulin resistance [homeostasis model assessment of insulin resistance (HOMA-IR)] increased from 2.1 ± 1.0 at baseline to 4.6 ± 1.9 at 12 months (p < 0.001). Insulin-like growth factor (IGF) binding protein 3 (IGFBP-3) decreased from 8,435 ± 4,477 ng/mL at baseline to 3,250 ± 1,780 ng/mL at 12 months (p < 0.001). The results show that GH exerted no effect on cerebral NAA or clinical progression assessed by ALSFRS-R. Two-thirds of ALS patients had GH deficit, with higher levels in the bulbar-onset group. During follow-up, patients showed progressive increase in HOMA-IR and decrease in IGFBP-3 levels. © 2011 Springer-Verlag.
Amyotrophic lateral sclerosis (ALS) is a fatal neurological disease with motor neuron degeneration. Riluzole is the only available treatment. Two-thirds of ALS patients present with growth hormone (GH) deficiency. The aim of this study is to determine if add-on of GH to riluzole, with an individually regulated dose based on Insulin-like growth factor 1 (IGF-I) production, was able to reduce neuronal loss in the motor cortex, reduce mortality, and improve motor function of ALS patients. Patients with definite/probable ALS, in treatment with riluzole, aged 40-85 years, and with disease duration ≥3 years were enrolled. The study was randomized, placebo controlled, and double blind. Before treatment, patients were tested with a GH releasing hormone (GHRH) + arginine test. The initial dose of GH was 2 IU s.c. every other day, and was progressively increased to a maximum of 8 IU. Primary endpoint was N-acetylaspartate/(creatine + choline) (NAA/Cre + Cho) ratio in motor cortex assessed by magnetic resonance spectroscopy performed at months 0, 6, and 12. Secondary endpoints were mortality and ALS functional rating scale revised (ALSFRS-R). The NAA/(Cre + Cho) ratio decreased in all patients who completed the trial. No significant difference was noted between treated and placebo group. At baseline, although IGF-I levels were within the normal range, 73% of patients had GH deficiency, being severe in half of them. Compared with bulbar onset, spinal-onset patients showed more depressed GH response to the GHRH + arginine stimulation test (10.4 ± 7.0 versus 15.5 ± 8.1 ng/mL; p < 0.05). Insulin resistance [homeostasis model assessment of insulin resistance (HOMA-IR)] increased from 2.1 ± 1.0 at baseline to 4.6 ± 1.9 at 12 months (p < 0.001). Insulin-like growth factor (IGF) binding protein 3 (IGFBP-3) decreased from 8,435 ± 4,477 ng/mL at baseline to 3,250 ± 1,780 ng/mL at 12 months (p < 0.001). The results show that GH exerted no effect on cerebral NAA or clinical progression assessed by ALSFRS-R. Two-thirds of ALS patients had GH deficit, with higher levels in the bulbar-onset group. During follow-up, patients showed progressive increase in HOMA-IR and decrease in IGFBP-3 levels. © 2011 Springer-Verlag.
A randomized controlled clinical trial of growth hormone in amyotrophic lateral sclerosis: clinical, neuroimaging, and hormonal results
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A randomized controlled clinical trial of growth hormone in amyotrophic lateral sclerosis: clinical, neuroimaging, and hormonal results
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De Leva MF, Filla A, Criscuolo C, Tessa A, Pappata S, Quarantelli M, Bilo L, Peluso S, Antenora A, Longo DL, Santorelli FM, De Michele G
* Complex phenotype in an Italian family with a novel mutation in SPG3A (700 views)
J Neurol (ISSN: 0340-5354, 1432-1459, 1432-1459electronic), 2010 Mar; 257(3): 328-331.
Impact Factor: 3.853
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Milardi D, Pappalardo M, Grasso DM, La Rosa C
* Unveiling the unfolding pathway of FALS associated G37R SOD1 mutant: A computational study (286 views)
Mol Biosyst (ISSN: 1742-206x), 2010; 6(6): 1032-1039.
Impact Factor: 3.825
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Cittadini A, Saldamarco L, Marra AM, Arcopinto M, Carlomagno G, Imbriaco M, Del Forno D, Vigorito C, Merola B, Oliviero U, Fazio S, Sacca L
* Growth Hormone Deficiency in Patients with Chronic Heart Failure and Beneficial Effects of Its Correction (544 views)
Journal Of Clinical Endocrinology & Metabolism (ISSN: 0021-972x), 2009 Sep; 94(9): 3329-3336.
Impact Factor: 6.202
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Sacca F, Quarantelli M, Rinaldi C, Tucci T, Piro R, Carotenuto B, Marsili A, Palma V, Bresciamorra V, Brunetti A, De Michele G, Filla A, Salvatore M
* A Double-Blind, Placebo-Controlled, Randomized Trial of Growth Hormone as Add-On Therapy to Riluzole in Patients with Amyotrophic Lateral Sclerosis: Preliminary MRS, Hormonal, and Population Analysis (369 views)
Neurology (ISSN: 0028-3878, 1526-632x, 1526-632xelectronic), 2009 Mar 17; 72(11): N/D-N/D.
Impact Factor: 8.172
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Sacca F, Quarantelli M, Rinaldi C, Tucci T, Piro R, Carotenuto B, Marsili A, Palma V, Bresciamorra V, Brunetti A, De Michele G, Filla A, Salvatore M
* A Randomized Trial of Growth Hormone as Add. On Therapy to Riluzole in Patients with Amyotrophic Lateral Sclerosis (297 views)
Neurology (ISSN: 0028-3878, 1526-632x, 1526-632xelectronic), 2009 Mar 17; 76(9): N/D-N/D.
Impact Factor: 8.172
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Colao A, Di Somma C, Cuocolo A, Spinelli L, Acampa W, Spiezia S, Rota F, Savanelli MC, Lombardi G
* Does a gender-related effect of growth hormone (GH) replacement exist on cardiovascular risk factors, cardiac morphology, and performance and atherosclerosis? Results of a two-year open, prospective study in young adult men and women with severe GH deficiency (403 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2005 Sep; 90(9): 5146-5155.
Impact Factor: 6.02
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Colao A, Di Somma C, Cuocolo A, Filippella M, Rota F, Acampa W, Savastano S, Salvatore M, Lombardi G
* The severity of growth hormone deficiency correlates with the severity of cardiac impairment in 100 adult patients with hypopituitarism: An observational, case-control study (271 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2004 Dec; 89(12): 5998-6004.
Impact Factor: 5.778
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Spinelli L, Petretta M, Verderame G, Carbone G, Venetucci AA, Petretta A, Acampa W, Bonaduce D, Colao A, Cuocolo A
* Left ventricular diastolic function and cardiac performance during exercise in patients with acromegaly (368 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2003 Sep; 88(9): 4105-4109.
Impact Factor: 5.873
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Colao A, Marzullo P, Cuocolo A, Spinelli L, Pivonello R, Bonaduce D, Salvatore M, Lombardi G
* Reversal of acromegalic cardiomyopathy in young but not in middle-aged patients after 12 months of treatment with the depot long-acting somatostatin analogue octreotide (407 views)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 2003 Feb; 58(2): 169-176.
Impact Factor: 2.767
View Export to BibTeX Export to EndNote
Colao A, Spinelli L, Cuocolo A, Spiezia S, Pivonello R, Di Somma C, Bonaduce D, Salvatore M, Lombardi G
* Cardiovascular consequences of early-onset growth hormone excess (362 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2002 Jul; 87(7): 3097-3104.
Impact Factor: 5.199
View Export to BibTeX Export to EndNote
Colao A, Di Somma C, Pivonello R, Cuocolo A, Spinelli L, Bonaduce D, Salvatore M, Lombardi G
* The cardiovascular risk of adult GH deficiency (GHD) improved after GH replacement and worsened in untreated GHD: A 12-month prospective study (357 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2002 Mar; 87(3): 1088-1093.
Impact Factor: 5.199
View Export to BibTeX Export to EndNote
Colao A, Di Somma C, Cuocolo A, Spinelli L, Tedesco N, Pivonello R, Bonaduce D, Salvatore M, Lombardi G
* Improved cardiovascular risk factors and cardiac performance after 12 months of growth hormone (GH) replacement in young adult patients, with GH deficiency (322 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2001 May; 86(5): 1874-1881.
Impact Factor: 5.16
View Export to BibTeX Export to EndNote
Colao A, Cuocolo A, Marzullo P, Nicolai E, Ferone D, Morte A, Pivonello R, Salvatore M, Lombardi G
* Is the acromegalic cardiomyopathy reversible? Effect of 5-year normalization of growth hormone and insulin-like growth factor I levels on cardiac performance (278 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2001 Apr; 86(4): 1551-1557.
Impact Factor: 5.16
View Export to BibTeX Export to EndNote
Colao A, Marzullo P, Ferone D, Spinelli L, Cuocolo A, Bonaduce D, Salvatore M, Boerlin V, Lancranjan I, Lombardi G
Cardiovascular effects of depot long-acting somatostatin analog sandostatin LAR in acromegaly (364 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2000 Sep; 85(9): 3132-3140.
Impact Factor: 5.447
View Export to BibTeX Export to EndNote
Marzullo P, Cuocolo A, Ferone D, Pivonello R, Salvatore M, Lombardi G, Colao A
Cardiac effect of thyrotoxicosis in acromegaly (358 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2000 Apr; 85(4): 1426-1432.
Impact Factor: 5.447
View Export to BibTeX Export to EndNote
Colao A, Cuocolo A, Di Somma C, Cerbone G, Della Morte A, Pivonello R, Nicolai E, Salvatore M, Lombardi G
Does the age of onset of growth hormone deficiency affect cardiac performance? A radionuclide angiography study (265 views)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 2000 Apr; 52(4): 447-455.
Impact Factor: 2.922
View Export to BibTeX Export to EndNote
Colao A, Cuocolo A, Di Somma C, Cerbone G, Della Morte A, Nicolai E, Lucci R, Salvatore M, Lombardi G
Impaired cardiac performance in elderly patients with growth hormone deficiency (289 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1999 Nov; 84(11): 3950-3955.
Impact Factor: 5.805
View Export to BibTeX Export to EndNote
Colao A, Cuocolo A, Marzullo P, Nicolai E, Ferone D, Della Morte A, Petretta M, Salvatore M, Lombardi G
Impact of patient's age and disease duration on cardiac performance in acromegaly: A radionuclide angiography study (257 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1999 May; 84(5): 1518-1523.
Impact Factor: 5.805
View Export to BibTeX Export to EndNote
Colao A, Lastoria S, Ferone D, Varrella P, Marzullo P, Pivonello R, Cerbone G, Acampa W, Salvatore M, Lombardi G
The pituitary uptake of In-111-DTPA-D-Phe(1)-octreotide in the normal pituitary and in pituitary adenomas (368 views)
J Endocrinol Invest (ISSN: 0391-4097, 1720-8386electronic), 1999 Mar; 22(3): 176-183.
Impact Factor: 0.957
View Export to BibTeX Export to EndNote
Colao A, Cuocolo A, Marzullo P, Nicolai E, Ferone D, Florimonte L, Salvatore M, Lombardi G
Effects of 1-year treatment with octreotide on cardiac performance in patients with acromegaly (324 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1999 Jan; 84(1): 17-23.
Impact Factor: 5.805
View Export to BibTeX Export to EndNote
Longobardi S, Cuocolo A, Merola B, Di Rella F, Colao A, Nicolai E, Cardei S, Salvatore M, Lombardi G
Left ventricular function in young adults with childhood and adulthood onset growth hormone deficiency (335 views)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 1998 Feb; 48(2): 137-143.
Impact Factor: 3.101
View Export to BibTeX Export to EndNote
Ferone D, Lastoria S, Colao A, Varrella P, Cerbone G, Acampa W, Merola B, Salvatore M, Lombardi G
Correlation of scintigraphic results using 123I-methoxybenzamide with hormone levels and tumor size response to quinagolide in patients with pituitary adenomas (298 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1998 Jan; 83(1): 248-252.
Impact Factor: 5.641
View Export to BibTeX Export to EndNote
Lombardi G, Colao A, Cuocolo A, Longobardi S, Di Somma C, Orio F, Merola B, Nicolai E, Salvatore M
Cardiological aspects of growth hormone and insulin-like growth factor- (326 views)
J Pediatr Endocrinol Metab (ISSN: 0334-018x), 1997 Nov; 10(6): 553-560.
Impact Factor: 0.481
View Export to BibTeX Export to EndNote
Sijens PE, Knopp MV, Brunetti A, Wicklow K, Alfano B, Bachert P, Sanders JA, Stillman AE, Kett H, Sauter R
1H MR spectroscopy in patients with metastatic brain tumors: A multicenter study (342 views)
Magn Reson Med (ISSN: 0740-3194, 1522-2594electronic, 0740-3194linking), 1995 Jun; 33(6): 818-826.
Impact Factor: 3.012
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* Growth hormone/IGF-1 axis longitudinal evaluation in clinically isolated syndrome patients on interferon beta-1b therapy: stimulation tests and correlations with clinical and radiological conversion to multiple sclerosis (248 views)
Eur J Neurol (ISSN: 1351-5101, 1468-1331electronic, 1351-5101linking), 2017 Feb; 24(2): 446-449.
Impact Factor: 4.621
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D'Andrea LD, Rosa LD, Vigliotti C, Cataldi M
* VEGF mimic peptides: Potential applications in central nervous system therapeutics (456 views)
New Horizons Transl Med (ISSN: 2307-5023), 2017; 3(5): 233-251.
Impact Factor: 0
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Gargiulo S, Gramanzini M, Coda ARD, Megna R, Panico M, Mancini M, Pappata S
* Animal Care in a Mouse Model of Amyotrophic Lateral Sclerosis Studied with [18F]DPA-714 Micro-PET/CT (243 views)
Comparative Medicine, 2016 Feb; 66(1): 76-76.
Impact Factor: 0
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Gargiulo S, Anzilotti S, Coda AR, Gramanzini M, Greco A, Panico M, Vinciguerra A, Zannetti A, Vicidomini C, Dolle F, Pignataro G, Quarantelli M, Annunziato L, Brunetti A, Salvatore M, Pappata S
* Imaging of brain TSPO expression in a mouse model of amyotrophic lateral sclerosis with (18)F-DPA-714 and micro-PET/CT (749 views) (PDF 294 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 1619-7070print), 2016 Jan 27; 43(7): 1348-1359.
Impact Factor: 7.277
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Cervo A, Cocozza S, Saccà F, Giorgio SM, Morra VB, Tedeschi E, Marsili A, Vacca G, Palma V, Brunetti A, Quarantelli M
* The combined use of conventional MRI and MR spectroscopic imaging increases the diagnostic accuracy in amyotrophic lateral sclerosis (389 views)
Eur J Radiol (ISSN: 0720-048x), 2015 Jan; 84(1): 151-157.
Impact Factor: 2.593
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Accardo A, Aloj L, Aurilio M, Morelli G, Tesauro D
* Receptor binding peptides for target-selective delivery of nanoparticles encapsulated drugs (529 views)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1176-9114linking), 2014 Mar 27; 9(1): 1537-1557.
Impact Factor: 4.383
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Dynkevich Y, Rother KI, Whitford I, Qureshi S, Galiveeti S, Szulc AL, Danoff A, Breen TL, Kaviani N, Shanik MH, LeRoith D, Vigneri R, Koch CA, Roth J
* Tumors, IGF-2, and Hypoglycemia: Insights From the Clinic, the Laboratory, and the Historical Archive (1418 views)
Endocrine Reviews (ISSN: 0163-769x), 2013 Dec; 34(6): 798-826.
Impact Factor: 19.358
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Caraci F, Battaglia G, Sortino MA, Spampinato S, Molinaro G, Copani A, Nicoletti F, Bruno V
* Metabotropic glutamate receptors in neurodegeneration/neuroprotection: Still a hot topic? (569 views)
Neurochem Int (ISSN: 0197-0186), 2012 Sep; 61(4): 559-565.
Impact Factor: 2.659
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Lanzillo R, Di Somma C, Quarantelli M, Ventrella G, Vacca G, Liuzzi R, Amato L, Orefice G, Colao A, Brescia Morra V
* Growth Hormone Axis In Early Multiple Sclerosis Patients Before And After 2 Years Treatment With Interferon Beta-1b - An Interim Analysis (246 views)
Proceedings Of The Xlii Meeting Of The Italian Society Of Neurology, 2011; nd: 360-360.
Impact Factor: 0
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De Leva MF, Filla A, Criscuolo C, Tessa A, Pappata S, Quarantelli M, Bilo L, Peluso S, Antenora A, Longo DL, Santorelli FM, De Michele G
* Complex phenotype in an Italian family with a novel mutation in SPG3A (700 views)
J Neurol (ISSN: 0340-5354, 1432-1459, 1432-1459electronic), 2010 Mar; 257(3): 328-331.
Impact Factor: 3.853
View Export to BibTeX Export to EndNote
Milardi D, Pappalardo M, Grasso DM, La Rosa C
* Unveiling the unfolding pathway of FALS associated G37R SOD1 mutant: A computational study (286 views)
Mol Biosyst (ISSN: 1742-206x), 2010; 6(6): 1032-1039.
Impact Factor: 3.825
View Export to BibTeX Export to EndNote
Cittadini A, Saldamarco L, Marra AM, Arcopinto M, Carlomagno G, Imbriaco M, Del Forno D, Vigorito C, Merola B, Oliviero U, Fazio S, Sacca L
* Growth Hormone Deficiency in Patients with Chronic Heart Failure and Beneficial Effects of Its Correction (544 views)
Journal Of Clinical Endocrinology & Metabolism (ISSN: 0021-972x), 2009 Sep; 94(9): 3329-3336.
Impact Factor: 6.202
View Export to BibTeX Export to EndNote
Sacca F, Quarantelli M, Rinaldi C, Tucci T, Piro R, Carotenuto B, Marsili A, Palma V, Bresciamorra V, Brunetti A, De Michele G, Filla A, Salvatore M
* A Double-Blind, Placebo-Controlled, Randomized Trial of Growth Hormone as Add-On Therapy to Riluzole in Patients with Amyotrophic Lateral Sclerosis: Preliminary MRS, Hormonal, and Population Analysis (369 views)
Neurology (ISSN: 0028-3878, 1526-632x, 1526-632xelectronic), 2009 Mar 17; 72(11): N/D-N/D.
Impact Factor: 8.172
View Export to BibTeX Export to EndNote
Sacca F, Quarantelli M, Rinaldi C, Tucci T, Piro R, Carotenuto B, Marsili A, Palma V, Bresciamorra V, Brunetti A, De Michele G, Filla A, Salvatore M
* A Randomized Trial of Growth Hormone as Add. On Therapy to Riluzole in Patients with Amyotrophic Lateral Sclerosis (297 views)
Neurology (ISSN: 0028-3878, 1526-632x, 1526-632xelectronic), 2009 Mar 17; 76(9): N/D-N/D.
Impact Factor: 8.172
View Export to BibTeX Export to EndNote
Colao A, Di Somma C, Cuocolo A, Spinelli L, Acampa W, Spiezia S, Rota F, Savanelli MC, Lombardi G
* Does a gender-related effect of growth hormone (GH) replacement exist on cardiovascular risk factors, cardiac morphology, and performance and atherosclerosis? Results of a two-year open, prospective study in young adult men and women with severe GH deficiency (403 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2005 Sep; 90(9): 5146-5155.
Impact Factor: 6.02
View Export to BibTeX Export to EndNote
Colao A, Di Somma C, Cuocolo A, Filippella M, Rota F, Acampa W, Savastano S, Salvatore M, Lombardi G
* The severity of growth hormone deficiency correlates with the severity of cardiac impairment in 100 adult patients with hypopituitarism: An observational, case-control study (271 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2004 Dec; 89(12): 5998-6004.
Impact Factor: 5.778
View Export to BibTeX Export to EndNote
Spinelli L, Petretta M, Verderame G, Carbone G, Venetucci AA, Petretta A, Acampa W, Bonaduce D, Colao A, Cuocolo A
* Left ventricular diastolic function and cardiac performance during exercise in patients with acromegaly (368 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2003 Sep; 88(9): 4105-4109.
Impact Factor: 5.873
View Export to BibTeX Export to EndNote
Colao A, Marzullo P, Cuocolo A, Spinelli L, Pivonello R, Bonaduce D, Salvatore M, Lombardi G
* Reversal of acromegalic cardiomyopathy in young but not in middle-aged patients after 12 months of treatment with the depot long-acting somatostatin analogue octreotide (407 views)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 2003 Feb; 58(2): 169-176.
Impact Factor: 2.767
View Export to BibTeX Export to EndNote
Colao A, Spinelli L, Cuocolo A, Spiezia S, Pivonello R, Di Somma C, Bonaduce D, Salvatore M, Lombardi G
* Cardiovascular consequences of early-onset growth hormone excess (362 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2002 Jul; 87(7): 3097-3104.
Impact Factor: 5.199
View Export to BibTeX Export to EndNote
Colao A, Di Somma C, Pivonello R, Cuocolo A, Spinelli L, Bonaduce D, Salvatore M, Lombardi G
* The cardiovascular risk of adult GH deficiency (GHD) improved after GH replacement and worsened in untreated GHD: A 12-month prospective study (357 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2002 Mar; 87(3): 1088-1093.
Impact Factor: 5.199
View Export to BibTeX Export to EndNote
Colao A, Di Somma C, Cuocolo A, Spinelli L, Tedesco N, Pivonello R, Bonaduce D, Salvatore M, Lombardi G
* Improved cardiovascular risk factors and cardiac performance after 12 months of growth hormone (GH) replacement in young adult patients, with GH deficiency (322 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2001 May; 86(5): 1874-1881.
Impact Factor: 5.16
View Export to BibTeX Export to EndNote
Colao A, Cuocolo A, Marzullo P, Nicolai E, Ferone D, Morte A, Pivonello R, Salvatore M, Lombardi G
* Is the acromegalic cardiomyopathy reversible? Effect of 5-year normalization of growth hormone and insulin-like growth factor I levels on cardiac performance (278 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2001 Apr; 86(4): 1551-1557.
Impact Factor: 5.16
View Export to BibTeX Export to EndNote
Colao A, Marzullo P, Ferone D, Spinelli L, Cuocolo A, Bonaduce D, Salvatore M, Boerlin V, Lancranjan I, Lombardi G
Cardiovascular effects of depot long-acting somatostatin analog sandostatin LAR in acromegaly (364 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2000 Sep; 85(9): 3132-3140.
Impact Factor: 5.447
View Export to BibTeX Export to EndNote
Marzullo P, Cuocolo A, Ferone D, Pivonello R, Salvatore M, Lombardi G, Colao A
Cardiac effect of thyrotoxicosis in acromegaly (358 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2000 Apr; 85(4): 1426-1432.
Impact Factor: 5.447
View Export to BibTeX Export to EndNote
Colao A, Cuocolo A, Di Somma C, Cerbone G, Della Morte A, Pivonello R, Nicolai E, Salvatore M, Lombardi G
Does the age of onset of growth hormone deficiency affect cardiac performance? A radionuclide angiography study (265 views)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 2000 Apr; 52(4): 447-455.
Impact Factor: 2.922
View Export to BibTeX Export to EndNote
Colao A, Cuocolo A, Di Somma C, Cerbone G, Della Morte A, Nicolai E, Lucci R, Salvatore M, Lombardi G
Impaired cardiac performance in elderly patients with growth hormone deficiency (289 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1999 Nov; 84(11): 3950-3955.
Impact Factor: 5.805
View Export to BibTeX Export to EndNote
Colao A, Cuocolo A, Marzullo P, Nicolai E, Ferone D, Della Morte A, Petretta M, Salvatore M, Lombardi G
Impact of patient's age and disease duration on cardiac performance in acromegaly: A radionuclide angiography study (257 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1999 May; 84(5): 1518-1523.
Impact Factor: 5.805
View Export to BibTeX Export to EndNote
Colao A, Lastoria S, Ferone D, Varrella P, Marzullo P, Pivonello R, Cerbone G, Acampa W, Salvatore M, Lombardi G
The pituitary uptake of In-111-DTPA-D-Phe(1)-octreotide in the normal pituitary and in pituitary adenomas (368 views)
J Endocrinol Invest (ISSN: 0391-4097, 1720-8386electronic), 1999 Mar; 22(3): 176-183.
Impact Factor: 0.957
View Export to BibTeX Export to EndNote
Colao A, Cuocolo A, Marzullo P, Nicolai E, Ferone D, Florimonte L, Salvatore M, Lombardi G
Effects of 1-year treatment with octreotide on cardiac performance in patients with acromegaly (324 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1999 Jan; 84(1): 17-23.
Impact Factor: 5.805
View Export to BibTeX Export to EndNote
Longobardi S, Cuocolo A, Merola B, Di Rella F, Colao A, Nicolai E, Cardei S, Salvatore M, Lombardi G
Left ventricular function in young adults with childhood and adulthood onset growth hormone deficiency (335 views)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 1998 Feb; 48(2): 137-143.
Impact Factor: 3.101
View Export to BibTeX Export to EndNote
Ferone D, Lastoria S, Colao A, Varrella P, Cerbone G, Acampa W, Merola B, Salvatore M, Lombardi G
Correlation of scintigraphic results using 123I-methoxybenzamide with hormone levels and tumor size response to quinagolide in patients with pituitary adenomas (298 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1998 Jan; 83(1): 248-252.
Impact Factor: 5.641
View Export to BibTeX Export to EndNote
Lombardi G, Colao A, Cuocolo A, Longobardi S, Di Somma C, Orio F, Merola B, Nicolai E, Salvatore M
Cardiological aspects of growth hormone and insulin-like growth factor- (326 views)
J Pediatr Endocrinol Metab (ISSN: 0334-018x), 1997 Nov; 10(6): 553-560.
Impact Factor: 0.481
View Export to BibTeX Export to EndNote
Sijens PE, Knopp MV, Brunetti A, Wicklow K, Alfano B, Bachert P, Sanders JA, Stillman AE, Kett H, Sauter R
1H MR spectroscopy in patients with metastatic brain tumors: A multicenter study (342 views)
Magn Reson Med (ISSN: 0740-3194, 1522-2594electronic, 0740-3194linking), 1995 Jun; 33(6): 818-826.
Impact Factor: 3.012
View Export to BibTeX Export to EndNote
33 Records (29 excluding Abstracts).
Total impact factor: 156.694 (140.35 excluding Abstracts).
Total 5 year impact factor: 125.674 (111.276 excluding Abstracts).
Total impact factor: 156.694 (140.35 excluding Abstracts).
Total 5 year impact factor: 125.674 (111.276 excluding Abstracts).
757 views. Last view on Tuesday 12 July 2022, 13:03:38
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