A randomized controlled clinical trial of growth hormone in amyotrophic lateral sclerosis: clinical, neuroimaging, and hormonal results
CNR Ibb | back to homepage
CNR Ibb | back to homepage
▲NavBar
Ricerca avanzata▼
Contiene: [X]      Estesa     Autori: [X]  Tipo di lavoro: [X]   Data iniziale: Data finale: [X]      Sede: Affiliazione IBB     
    
[Pulisci modulo]


A randomized controlled clinical trial of growth hormone in amyotrophic lateral sclerosis: clinical, neuroimaging, and hormonal results (262 visite)

Saccà F, Quarantelli M, Rinaldi C, Tucci T, Piro R, Perrotta G, Carotenuto B, Marsili A, Palma V, De Michele G, Brunetti A, Brescia Morra V, Filla A, Salvatore M

J Neurol (ISSN: 1432-1459, 0340-5354, 1432-1459electronic), 2012 Jan; 259(1): 132-138.



Tipo di articolo: Journal Article, Clinical Trial, Phase Ii, Randomized Controlled Trial, Research Support, Non-U. S. Gov'T,

Impact factor: 3.578, Impact factor a 5 anni: 3.598

Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84856701376&partnerID=40&md5=9adf7ccdcb1d74076ea7dad4ceb8723a

Parole chiave: Amyotrophic Lateral Sclerosis, Growth Hormone, Homa-Ir, Igf-I, Igfbp-3, Insulin, Arginine, Choline, Creatine, Gonadorelin, Human Growth Hormone, N Acetylaspartic Acid, Placebo, Riluzole, Somatomedin Binding Protein 3, Adult, Aged, Amyotrophic Lateral Sclerosis Functional Rating Scale Revised, Clinical Article, Controlled Study, Disease Course, Disease Duration, Disease Severity, Double Blind Procedure, Drug Dose Increase, Female, Glucose Blood Level, Growth Hormone Deficiency, Hormone Determination, Hypertension, Injection Site Reaction, Insulin Resistance, Joint Stiffness, Joint Swelling, Limb Weakness, Mortality, Motor Cortex, Motor Performance, Neuroimaging, Nuclear Magnetic Resonance Spectroscopy, Peripheral Edema, Phase 2 Clinical Trial, Priority Journal, Randomized Controlled Trial, Side Effect, 80 And Over, Double-Blind Method, Endpoint Determination, Image Processing, Computer-Assisted, Insulin-Like Growth Factor Binding Protein 3, Magnetic Resonance Imaging, Middle Aged, Neuroprotective Agents, Recombinant Proteins,

Affiliazioni:

*** IBB - CNR ***
Department of Neurological Sciences, University Federico II, Via Pansini, 5, 80131 Naples, NA, Italy. francesco.sacca@unina.it
Biostructure and Bioimaging Institute, National Research Council, Naples, Italy
U.O.C. Neurofisiopatologia, PO S. Gennaro ASL Napoli 1, Naples, Italy
U. O. C. Neurofisiopatologia, PO S. Gennaro ASL Napoli 1, Naples, Italy


Riferimenti:

Bensimon, G., Lacomblez, L., Meininger, V., A controlled trial of riluzole in amyotrophic lateral sclerosis (1994) New England Journal of Medicine, 330 (9), pp. 585-591. , DOI 10.1056/NEJM19940303330090

Morselli, L.L., Bongioanni, P., Genovesi, M., Growth hormone secretion is impaired in amyotrophic lateral sclerosis (2006) Clin Endocrinol (Oxf), 65, pp. 385-388. , 10.1111/j.1365-2265.2006.02609.x 1:CAS:528:DC%2BD28XhtVOqtLjK

Lai, E.C., Felice, K.J., Festoff, B.W., Gawel, M.J., Gelinas, D.F., Kratz, R., Murphy, M.F., Rudnicki, S.A., Effect of recombinant human insulin-like growth factor-I on progression of ALS: A placebo-controlled study (1997) Neurology, 49 (6), pp. 1621-1630

Borasio, G.D., Robberecht, W., Leigh, P.N., Emile, J., Guiloff, R.J., Jerusalem, F., Silani, V., Dobbins, T., A placebo-controlled trial of insulin-like growth factor-I in amyotrophic lateral sclerosis (1998) Neurology, 51 (2), pp. 583-586

Sorenson, E.J., Windbank, A.J., Mandrekar, J.N., Subcutaneous IGF-1 is not beneficial in 2-year ALS trial (2008) Neurology, 71, pp. 1770-1775. , 19029516 10.1212/01.wnl.0000335970.78664.36 1:CAS:528:DC%2BD1cXhtlylurjK

Smith, R.A., Melmed, S., Sherman, B., Frane, J., Munsat, T.L., Festoff, B.W., Recombinant growth hormone treatment of amyotrophic lateral sclerosis (1993) Muscle and Nerve, 16 (6), pp. 624-633. , DOI 10.1002/mus.880160608

Cedarbaum, J.M., Stambler, N., Malta, E., Fuller, C., Hilt, D., Thurmond, B., Nakanishi, A., The ALSFRS-R: A revised ALS functional rating scale that incorporates assessments of respiratory function (1999) Journal of the Neurological Sciences, 169 (1-2), pp. 13-21. , DOI 10.1016/S0022-510X(99)00210-5, PII S0022510X99002105

Suhy, J., Miller, R.G., Rule, R., Schuff, N., Licht, J., Dronsky, V., Gelinas, D., Weiner, M.W., Early detection and longitudinal changes in amyotrophic lateral sclerosis by 1H MRSI (2002) Neurology, 58 (5), pp. 773-779

Matthews, D.R., Hosker, J.P., Rudenski, A.S., Homeostasis model assessment: Insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man (1985) Diabetologia, 28 (7), pp. 412-419. , DOI 10.1007/BF00280883

Aberg, N.D., Lind, J., Isgaard, J., Georg Kuhn, H., Peripheral growth hormone induces cell proliferation in the intect adult rat brain (2010) Growth Horm IGF Res, 20, pp. 264-269. , 10.1016/j.ghir.2009.12.003

Kaspar, B.K., Frost, L.M., Christian, L., Umapathi, P., Gage, F.H., Synergy of insulin-like growth factor-1 and exercise in amyotrophic lateral sclerosis (2005) Annals of Neurology, 57 (5), pp. 649-655. , DOI 10.1002/ana.20451

Kaspar, B.K., Llado, J., Sherkat, N., Rothstein, J.D., Gage, F.H., Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model (2003) Science, 301 (5634), pp. 839-842. , DOI 10.1126/science.1086137

Buckway, C.K., Guevara-Aguirre, J., Pratt, K.L., Burren, C.P., Rosenfeld, R.G., The IGF-I generation test revisited: A marker of GH sensitivity (2001) Journal of Clinical Endocrinology and Metabolism, 86 (11), pp. 5176-5183. , DOI 10.1210/jc.86.11.5176

Pellecchia, M.T., Pivonello, R., Monsurro, M.R., The GH-IGF system in amyotrophic lateral sclerosis: Correlations between pituitary GH secretion capacity, insulin-like growth factors and clinical features (2010) Eur J Neurol, 17, pp. 666-671. , 20002733 10.1111/j.1468-1331.2009.02896.x 1:STN:280: DC%2BC3czpsVKhsw%3D%3D

Salvatore, E., Rinaldi, C., Tucci, T., Growth hormone response to arginine test differentiates between two subgroups of Huntington's disease patients (2011) J Neurol Neurosurg Psychiatry, 82, pp. 543-547

Reyes, E.T., Perurena, O.H., Festoff, B.W., Insulin resistance in amyotrophic lateral sclerosis (1984) Journal of the Neurological Sciences, 63 (3), pp. 317-324. , DOI 10.1016/0022-510X(84)90154-0

Pradat, P.F., Bruneteau, G., Gordon, P.H., Impaired glucose tolerance in patients with amyotrophic lateral sclerosis (2010) Amyotroph Lateral Scler, 11, pp. 166-171. , 20184518 10.3109/17482960902822960 1:CAS:528:DC%2BC3cXisV2msbw%3D

Torres-Aleman, I., Barrios, V., Berciano, J., The peripheral insulin-like growth factor system in amyotrophic lateral sclerosis (1998) Neurology, 50, pp. 772-776. , 9521273 1:STN:280:DyaK1c7otVGluw%3D%3D

Corbo, M., Lunetta, C., Magni, P., Free insulin-like growth factor (IGF)-1 and IGF-binding proteins-2 and -3 in serum and cerebrospinal fluid of amyotrophic lateral sclerosis patients (2010) Eur J Neurol, 17, pp. 398-404. , 19845745 10.1111/j.1468-1331.2009.02815.x 1:STN:280: DC%2BC3czitlGquw%3D%3D

Hosback, S., Hardiman, O., Nolan, C.M., Doyle, M.A.C., Gorman, G., Lynch, C., O'Toole, O., Jakeman, P., Circulating insulin-like growth factors and related binding proteins are selectively altered in amyotrophic lateral sclerosis and multiple sclerosis (2007) Growth Hormone and IGF Research, 17 (6), pp. 472-479. , DOI 10.1016/j.ghir.2007.06.002, PII S109663740700086X

Olivecrona, H., Hilding, A., Ekstrom, C., Barle, H., Nyberg, B., Moller, C., Delhanty, P.J., Tally, M., Acute and short-term effects of growth hormone on insulin-like growth factors and their binding proteins: Serum levels and hepatic messenger ribonucleic acid responses in humans (1999) Journal of Clinical Endocrinology and Metabolism, 84 (2), pp. 553-560. , DOI 10.1210/jc.84.2.553

Butt, A.J., Firth, S.M., King, M.A., Baxter, R.C., Insulin-like growth factor-binding protein-3 modulates expression of Bax and Bcl-2 and potentiates p53-independent radiation-induced apoptosis in human breast cancer cells (2000) Journal of Biological Chemistry, 275 (50), pp. 39174-39181. , DOI 10.1074/jbc.M908888199

Liao, L., Dearth, R.K., Zhou, S., Britton, O.L., Lee, A.V., Xu, J., Liver-specific overexpression of the insulin-like growth factor-I enhances somatic growth and partially prevents the effects of growth hormone deficiency (2006) Endocrinology, 147 (8), pp. 3877-3888. , http://endo.endojournals.org/cgi/reprint/147/8/3877, DOI 10.1210/en.2005-1537

Niebroj-Dobosz, I., Janik, P., Soko-Çowska, B., Kwiecinski, H., Matrix metalloproteinases and their tissue inhibitors in serum and cerebrospinal fluid of patients with amyotrophic lateral sclerosis (2010) Eur J Neurol, 17, pp. 226-231. , 19796283 10.1111/j.1468-1331.2009.02775.x 1:STN:280: DC%2BC3czitlGjuw%3D%3D

Mitsui, Y., Mochizuki, S., Kodama, T., Shimoda, M., Ohtsuka, T., Shiomi, T., Chijiiwa, M., Okada, Y., ADAM28 is overexpressed in human breast carcinomas: Implications for carcinoma cell proliferation through cleavage of insulin-like growth factor binding protein-3 (2006) Cancer Research, 66 (20), pp. 9913-9920. , DOI 10.1158/0008-5472.CAN-06-0377



Amyotrophic lateral sclerosis (ALS) is a fatal neurological disease with motor neuron degeneration. Riluzole is the only available treatment. Two-thirds of ALS patients present with growth hormone (GH) deficiency. The aim of this study is to determine if add-on of GH to riluzole, with an individually regulated dose based on Insulin-like growth factor 1 (IGF-I) production, was able to reduce neuronal loss in the motor cortex, reduce mortality, and improve motor function of ALS patients. Patients with definite/probable ALS, in treatment with riluzole, aged 40-85 years, and with disease duration ≥3 years were enrolled. The study was randomized, placebo controlled, and double blind. Before treatment, patients were tested with a GH releasing hormone (GHRH) + arginine test. The initial dose of GH was 2 IU s.c. every other day, and was progressively increased to a maximum of 8 IU. Primary endpoint was N-acetylaspartate/(creatine + choline) (NAA/Cre + Cho) ratio in motor cortex assessed by magnetic resonance spectroscopy performed at months 0, 6, and 12. Secondary endpoints were mortality and ALS functional rating scale revised (ALSFRS-R). The NAA/(Cre + Cho) ratio decreased in all patients who completed the trial. No significant difference was noted between treated and placebo group. At baseline, although IGF-I levels were within the normal range, 73% of patients had GH deficiency, being severe in half of them. Compared with bulbar onset, spinal-onset patients showed more depressed GH response to the GHRH + arginine stimulation test (10.4 ± 7.0 versus 15.5 ± 8.1 ng/mL; p < 0.05). Insulin resistance [homeostasis model assessment of insulin resistance (HOMA-IR)] increased from 2.1 ± 1.0 at baseline to 4.6 ± 1.9 at 12 months (p < 0.001). Insulin-like growth factor (IGF) binding protein 3 (IGFBP-3) decreased from 8,435 ± 4,477 ng/mL at baseline to 3,250 ± 1,780 ng/mL at 12 months (p < 0.001). The results show that GH exerted no effect on cerebral NAA or clinical progression assessed by ALSFRS-R. Two-thirds of ALS patients had GH deficit, with higher levels in the bulbar-onset group. During follow-up, patients showed progressive increase in HOMA-IR and decrease in IGFBP-3 levels. © 2011 Springer-Verlag.
Nessun risultato.

Ricerca avanzata▼
Contiene: [X]      Estesa     Autori: [X]  Tipo di lavoro: [X]   Data iniziale: Data finale: [X]      Sede: Affiliazione IBB     
    
[Pulisci modulo]
Vai a fine pagina   Versione per copia e incolla facile   Esporta tutto in BibTeX   Esporta tutto in EndNote


Balasco N, Smaldone G, Vigorita M, Del Vecchio P, Graziano G, Ruggiero A, Vitagliano L
* The characterization of Thermotoga maritima Arginine Binding Protein variants demonstrates that minimal local strains have an important impact on protein stability (9 visite)
Sci Rep (ISSN: 2045-2322linking), 2019 Apr 29; 9(1): 6617-6617.
Impact Factor: 5.078
Dettagli    Esporta in BibTeX    Esporta in EndNote

Smaldone G, Balasco N, Vigorita M, Ruggiero A, Cozzolino S, Berisio R, Del Vecchio P, Graziano G, Vitagliano L
* Domain communication in Thermotoga maritima Arginine Binding Protein unraveled through protein dissection (94 visite)
Int J Biol Macromol (ISSN: 0141-8130linking, 1879-0003electronic), 2018 Nov; 119: 758-769.
Impact Factor: 3.909
Dettagli    Esporta in BibTeX    Esporta in EndNote

Smaldone G, Berisio R, Balasco N, D'Auria S, Vitagliano L, Ruggiero A
* Domain swapping dissection in Thermotoga maritima arginine binding protein: How structural flexibility may compensate destabilization (90 visite)
Bba-Gen Subjects (ISSN: 1570-9639print, 1570-9639linking, 0005-2728), 2018 May 31; 1866(9): 952-962.
Impact Factor: 2.773
Dettagli    Esporta in BibTeX    Esporta in EndNote

Goerke S, Breitling J, Zaiss M, Windschuh J, Kunz P, Schuenke P, Paech D, Longo DL, Klika KD, Ladd ME, Bachert P
* Dual-frequency irradiation CEST-MRI of endogenous bulk mobile proteins (125 visite)
Nmr Biomed (ISSN: 0952-3480, 1099-1492electronic, 0952-3480linking), 2018 Apr; 31(6): N/D-N/D.
Impact Factor: 2.872
Dettagli    Esporta in BibTeX    Esporta in EndNote

Depalo N, Corricelli M, De Paola I, Valente G, Iacobazzi RM, Altamura E, Debellis D, Comegna D, Fanizza E, Denora N, Laquintana V, Mavelli F, Striccoli M, Saviano M, Agostiano A, Del Gatto A, Zaccaro L, Curri ML
* NIR Emitting Nanoprobes Based on Cyclic RGD Motif Conjugated PbS Quantum Dots for Integrin-Targeted Optical Bioimaging (202 visite) (PDF 119 visite)
Acs Appl Mater Inter (ISSN: 1944-8244), 2017 Dec 13; 9(49): 43113-43126.
Impact Factor: 8.097
Dettagli    Esporta in BibTeX    Esporta in EndNote

Lanzillo R, Di Somma C, Quarantelli M, Carotenuto A, Pivonello C, Moccia M, Cianflone A, Marsili A, Puorro G, Sacca F, Russo CV, De Luca Picione C, Ausiello F, Colao A, Brescia Morra V
* Growth hormone/IGF-1 axis longitudinal evaluation in clinically isolated syndrome patients on interferon beta-1b therapy: stimulation tests and correlations with clinical and radiological conversion to multiple sclerosis (161 visite)
Eur J Neurol (ISSN: 1351-5101, 1468-1331electronic), 2017 Feb; 24(2): 446-449.
Impact Factor: 4.621
Dettagli    Esporta in BibTeX    Esporta in EndNote

D'Andrea LD, Rosa LD, Vigliotti C, Cataldi M
* VEGF mimic peptides: Potential applications in central nervous system therapeutics (167 visite)
New Horizons Transl Med (ISSN: 2307-5023), 2017; 3(5): 233-251.
Impact Factor: 0
Dettagli    Esporta in BibTeX    Esporta in EndNote

Troise AD, Buonanno M, Fiore A, Monti SM, Fogliano V
* Evolution of protein bound Maillard reaction end-products and free Amadori compounds in low lactose milk in presence of fructosamine oxidase (170 visite)
Food Chem (ISSN: 0308-8146, 0308-8146print), 2016 Dec 1; 212: 722-729.
Impact Factor: 4.529
Dettagli    Esporta in BibTeX    Esporta in EndNote

Smaldone G, Vigorita M, Ruggiero A, Balasco N, Dattelbaum JD, D'Auria S, Del Vecchio P, Graziano G, Vitagliano L
* Proline 235 plays a key role in the regulation of the oligomeric states of Thermotoga maritima Arginine Binding Protein (170 visite)
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 1570-9639print), 2016 Jul; 1864(7): 814-824.
Impact Factor: 4.932
Dettagli    Esporta in BibTeX    Esporta in EndNote

Gargiulo S, Gramanzini M, Coda ARD, Megna R, Panico M, Mancini M, Pappata S
* Animal Care in a Mouse Model of Amyotrophic Lateral Sclerosis Studied with [18F]DPA-714 Micro-PET/CT (151 visite)
Comparative Medicine, 2016 Feb; 66(1): 76-76.
Impact Factor: 0
Dettagli    Esporta in BibTeX    Esporta in EndNote

Gargiulo S, Anzilotti S, Coda AR, Gramanzini M, Greco A, Panico M, Vinciguerra A, Zannetti A, Vicidomini C, Dolle F, Pignataro G, Quarantelli M, Annunziato L, Brunetti A, Salvatore M, Pappata S
* Imaging of brain TSPO expression in a mouse model of amyotrophic lateral sclerosis with (18)F-DPA-714 and micro-PET/CT (630 visite) (PDF 247 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 1619-7070print), 2016 Jan 27; 43(7): 1348-1359.
Impact Factor: 7.277
Dettagli    Esporta in BibTeX    Esporta in EndNote

Roviello GN, Vicidomini C, Di Gaetano S, Capasso D, Musumeci D, Roviello V
* Solid phase synthesis and RNA-binding activity of an arginine-containing nucleopeptide (234 visite)
Rsc Adv (ISSN: 2046-2069), 2016; 6(17): 14140-14148.
Impact Factor: 3.108
Dettagli    Esporta in BibTeX    Esporta in EndNote

Troise AD, Fiore A, Roviello GN, Monti SM, Fogliano V
* Simultaneous quantification of amino acids and Amadori products in foods through ion-pairing liquid chromatography-high-resolution mass spectrometry (284 visite)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2015 Jan; 47(1): 111-124.
Impact Factor: 3.196
Dettagli    Esporta in BibTeX    Esporta in EndNote

Cervo A, Cocozza S, Saccà F, Giorgio SM, Morra VB, Tedeschi E, Marsili A, Vacca G, Palma V, Brunetti A, Quarantelli M
* The combined use of conventional MRI and MR spectroscopic imaging increases the diagnostic accuracy in amyotrophic lateral sclerosis (245 visite)
Eur J Radiol (ISSN: 0720-048x), 2015 Jan; 84(1): 151-157.
Impact Factor: 2.593
Dettagli    Esporta in BibTeX    Esporta in EndNote

Ruggiero L, Fiorillo C, Tessa A, Manganelli F, Iodice R, Dubbioso R, Vitale F, Storti E, Soscia E, Santorelli F, Santoro L
* Muscle fiber type disproportion (FTD) in a family with mutations in the LMNA gene (161 visite)
Muscle Nerve (ISSN: 0148-639x), 2015; 51(4): 604-608.
Impact Factor: 2.713
Dettagli    Esporta in BibTeX    Esporta in EndNote

Cantisani M, Finamore E, Mignogna E, Falanga A, Nicoletti GF, Pedone C, Morelli G, Leone M, Galdiero M, Galdiero S
* Structural insights into and activity analysis of the antimicrobial peptide myxinidin (320 visite)
Antimicrob Agents Ch (ISSN: 0066-4804, 1098-6596), 2014 Sep; 58(9): 5280-5290.
Impact Factor: 4.476
Dettagli    Esporta in BibTeX    Esporta in EndNote

Ruggiero A, Dattelbaum JD, Staiano M, Berisio R, D'Auria S, Vitagliano L
* A loose domain swapping organization confers a remarkable stability to the dimeric structure of the arginine binding protein from Thermotoga maritima (235 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2014 May 15; 9(5): e96560-e96560.
Impact Factor: 3.234
Dettagli    Esporta in BibTeX    Esporta in EndNote

Accardo A, Aloj L, Aurilio M, Morelli G, Tesauro D
* Receptor binding peptides for target-selective delivery of nanoparticles encapsulated drugs (336 visite)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1176-9114linking), 2014 Mar 27; 9(1): 1537-1557.
Impact Factor: 4.383
Dettagli    Esporta in BibTeX    Esporta in EndNote

Merlino A, Russo Krauss I, Castellano I, Ruocco MR, Capasso A, De Vendittis E, Rossi B, Sica F
* Structural and denaturation studies of two mutants of a cold adapted superoxide dismutase point to the importance of electrostatic interactions in protein stability (274 visite)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2014 Mar; 1844(3): 632-640.
Impact Factor: 4.882
Dettagli    Esporta in BibTeX    Esporta in EndNote

Dynkevich Y, Rother KI, Whitford I, Qureshi S, Galiveeti S, Szulc AL, Danoff A, Breen TL, Kaviani N, Shanik MH, LeRoith D, Vigneri R, Koch CA, Roth J
* Tumors, IGF-2, and Hypoglycemia: Insights From the Clinic, the Laboratory, and the Historical Archive (875 visite)
Endocrine Reviews (ISSN: 0163-769x), 2013 Dec; 34(6): 798-826.
Impact Factor: 19.358
Dettagli    Esporta in BibTeX    Esporta in EndNote

Cantisani M, Leone M, Mignogna E, Kampanaraki K, Falanga A, Morelli G, Galdiero M, Galdiero S
* Structure-Activity Relations of Myxinidin, an Antibacterial Peptide Derived from the Epidermal Mucus of Hagfish (338 visite)
Antimicrob Agents Ch (ISSN: 0066-4804, 1098-6596), 2013 Nov; 57(11): 5665-5673.
Impact Factor: 4.451
Dettagli    Esporta in BibTeX    Esporta in EndNote

Scalia M, Satriano C, Greca R, Stella AM, Rizzarelli E, Spina-Purrello V
* PARP-1 inhibitors DPQ and PJ-34 negatively modulate proinflammatory commitment of human glioblastoma cells (260 visite)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2013 Jan; 38(1): 50-58.
Impact Factor: 2.551
Dettagli    Esporta in BibTeX    Esporta in EndNote

Caraci F, Battaglia G, Sortino MA, Spampinato S, Molinaro G, Copani A, Nicoletti F, Bruno V
* Metabotropic glutamate receptors in neurodegeneration/neuroprotection: Still a hot topic? (255 visite)
Neurochem Int (ISSN: 0197-0186), 2012 Sep; 61(4): 559-565.
Impact Factor: 2.659
Dettagli    Esporta in BibTeX    Esporta in EndNote

Galdiero S, Vitiello M, Falanga A, Cantisani M, Incoronato N, Galdiero M
* Intracellular Delivery: Exploiting Viral Membranotropic Peptides (324 visite)
Current Drug Metabolism (ISSN: 1389-2002), 2012 Jan; 13(1): 93-104.
Impact Factor: 4.405
Dettagli    Esporta in BibTeX    Esporta in EndNote

Squeglia F, Marchetti R, Ruggiero A, Lanzetta R, Marasco D, Dworkin J, Petoukhov M, Molinaro A, Berisio R, Silipo A
* Chemical basis of peptidoglycan discrimination by PrkC, a key kinase involved in bacterial resuscitation from dormancy (223 visite)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2011 Dec 28; 133(51): 20676-20679.
Impact Factor: 9.907
Dettagli    Esporta in BibTeX    Esporta in EndNote

Ruggiero A, Dattelbaum JD, Pennacchio A, Iozzino L, Staiano M, Luchansky MS, Der BS, Berisio R, D'Auria S, Vitagliano L
* Crystallization and preliminary X-ray crystallographic analysis of ligand-free and arginine-bound forms of Thermotoga maritima arginine-binding protein (246 visite)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2011 Nov 1; 67(11): 1462-1465.
Impact Factor: 0.506
Dettagli    Esporta in BibTeX    Esporta in EndNote

Lanzillo R, Di Somma C, Quarantelli M, Ventrella G, Vacca G, Liuzzi R, Amato L, Orefice G, Colao A, Brescia Morra V
* Growth Hormone Axis In Early Multiple Sclerosis Patients Before And After 2 Years Treatment With Interferon Beta-1b - An Interim Analysis (166 visite)
Proceedings Of The Xlii Meeting Of The Italian Society Of Neurology, 2011; nd: 360-360.
Impact Factor: 0
Dettagli    Esporta in BibTeX    Esporta in EndNote

Roviello GN, Crescenzo C, Capasso D, Di Gaetano S, Franco S, Bucci EM, Pedone C
* Synthesis of a novel Fmoc-protected nucleoaminoacid for the solid phase assembly of 4-piperidyl glycine/L-arginine-containing nucleopeptides and preliminary RNA interaction studies (252 visite)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 Sep; 39(3): 795-800.
Impact Factor: 4.106
Dettagli    Esporta in BibTeX    Esporta in EndNote

Lanzillo R, Orefice G, Quarantelli M, Rinaldi C, Prinster A, Ventrella G, Spitaleri D, Lus G, Vacca G, Carotenuto B, Salvatore E, Brunetti A, Tedeschi G, Brescia Morra V
* Atorvastatin combined to interferon to verify the efficacy (ACTIVE) in relapsing-remitting active multiple sclerosis patients: A longitudinal controlled trial of combination therapy (269 visite)
Mult Scler (ISSN: 1352-4585, 1477-0970, 1352-4585linking), 2010 Apr; 16(4): 450-454.
Impact Factor: 4.23
Dettagli    Esporta in BibTeX    Esporta in EndNote

De Leva MF, Filla A, Criscuolo C, Tessa A, Pappata S, Quarantelli M, Bilo L, Peluso S, Antenora A, Longo DL, Santorelli FM, De Michele G
* Complex phenotype in an Italian family with a novel mutation in SPG3A (224 visite)
J Neurol (ISSN: 0340-5354, 1432-1459, 1432-1459electronic), 2010 Mar; 257(3): 328-331.
Impact Factor: 3.853
Dettagli    Esporta in BibTeX    Esporta in EndNote

Luchansky MS, Der BS, D'Auria S, Pocsfalvi G, Iozzino L, Marasco D, Dattelbaum JD
* Amino acid transport in thermophiles: characterization of an arginine-binding protein in Thermotoga maritima (213 visite)
Molecular Biosystems (ISSN: 1742-206x), 2010; 6(1): 142-151.
Impact Factor: 3.825
Dettagli    Esporta in BibTeX    Esporta in EndNote

D'Antò V, Michelotti A, Esposito L, Zagari A, Liguori R, Sacchetti L
* Nonsynonimous mutation of catechol-O-methyl-transferase (COMT) gene in a patient with temporomandibular disorder (194 visite)
J Sci Med Sport (ISSN: 1440-2440), 2010; 13(6): 174-179.
Impact Factor: 3.194
Dettagli    Esporta in BibTeX    Esporta in EndNote

Milardi D, Pappalardo M, Grasso DM, La Rosa C
* Unveiling the unfolding pathway of FALS associated G37R SOD1 mutant: A computational study (177 visite)
Mol Biosyst (ISSN: 1742-206x), 2010; 6(6): 1032-1039.
Impact Factor: 3.825
Dettagli    Esporta in BibTeX    Esporta in EndNote

Cittadini A, Saldamarco L, Marra AM, Arcopinto M, Carlomagno G, Imbriaco M, Del Forno D, Vigorito C, Merola B, Oliviero U, Fazio S, Sacca L
* Growth Hormone Deficiency in Patients with Chronic Heart Failure and Beneficial Effects of Its Correction (223 visite)
Journal Of Clinical Endocrinology & Metabolism (ISSN: 0021-972x), 2009 Sep; 94(9): 3329-3336.
Impact Factor: 6.202
Dettagli    Esporta in BibTeX    Esporta in EndNote

D'Ambrosio K, Limauro D, Pedone E, Galdi I, Pedone C, Bartolucci S, De Simone G
* Insights into the catalytic mechanism of the Bcp family: functional and structural analysis of Bcp1 from Sulfolobus solfataricus (239 visite)
Proteins (ISSN: 1097-0134, 0887-3585, 1097-0134electronic), 2009 Sep; 76(4): 995-1006.
Impact Factor: 3.085
Dettagli    Esporta in BibTeX    Esporta in EndNote

Carriero MV, Longanesi-cattani I, Bifulco K, Maglio O, Lista L, Barbieri A, Votta G, Masucci MT, Arra C, Franco R, De Rosa M, Stoppelli MP, Pavone V
* Structure-based design of an urokinase-type plasminogen activator receptor-derived peptide inhibiting cell migration and lung metastasis (267 visite)
Mol Cancer Ther (ISSN: 1535-7163, 1538-8514electronic, 1535-7163linking), 2009 Sep; 8(9): 2708-2717.
Impact Factor: 4.953
Dettagli    Esporta in BibTeX    Esporta in EndNote

Sacca F, Quarantelli M, Rinaldi C, Tucci T, Piro R, Carotenuto B, Marsili A, Palma V, Bresciamorra V, Brunetti A, De Michele G, Filla A, Salvatore M
* A Double-Blind, Placebo-Controlled, Randomized Trial of Growth Hormone as Add-On Therapy to Riluzole in Patients with Amyotrophic Lateral Sclerosis: Preliminary MRS, Hormonal, and Population Analysis (285 visite)
Neurology (ISSN: 0028-3878, 1526-632x, 1526-632xelectronic), 2009 Mar 17; 72(11): N/D-N/D.
Impact Factor: 8.172
Dettagli    Esporta in BibTeX    Esporta in EndNote

Sacca F, Quarantelli M, Rinaldi C, Tucci T, Piro R, Carotenuto B, Marsili A, Palma V, Bresciamorra V, Brunetti A, De Michele G, Filla A, Salvatore M
* A Randomized Trial of Growth Hormone as Add. On Therapy to Riluzole in Patients with Amyotrophic Lateral Sclerosis (213 visite)
Neurology (ISSN: 0028-3878, 1526-632x, 1526-632xelectronic), 2009 Mar 17; 76(9): N/D-N/D.
Impact Factor: 8.172
Dettagli    Esporta in BibTeX    Esporta in EndNote

Cittadini A, Monti MG, Castiello MC, D'Arco E, Galasso G, Sorriento D, Saldamarco L, De Paulis A, Napoli R, Iaccarino G, Saccà L
* Insulin-like growth factor-1 protects from vascular stenosis and accelerates re-endothelialization in a rat model of carotid artery injury (226 visite)
J Thromb Haemost Journal Of Thrombosis And Haemostasis (ISSN: 1538-7933), 2009; 7(11): 1920-1928.
Impact Factor: 6.069
Dettagli    Esporta in BibTeX    Esporta in EndNote

Dudar GK, D'Andrea LD, Di Stasi R, Pedone C, Wallace JL
* A vascular endothelial growth factor mimetic accelerates gastric ulcer healing in an iNOS-dependent manner (211 visite)
Am J Physiol Gastrointest Liver Physiol American Journal Of Physiology Gastrointestinal And Liver Physiology (ISSN: 0193-1857), 2008 Sep; 295(2): G374-G374.
Impact Factor: 3.587
Dettagli    Esporta in BibTeX    Esporta in EndNote

De Simone A, Vitagliano L, Berisio R
* Role of hydration in collagen triple helix stabilization (219 visite)
Biochem Biophys Res Commun (ISSN: 0006-291x), 2008 Jul 18; 372(1): 121-125.
Impact Factor: 2.648
Dettagli    Esporta in BibTeX    Esporta in EndNote

Gallotta G, Palmieri V, Piedimonte V, Rendina D, De Bonis S, Russo V, Celentano A, Di Minno M, Postiglione A, Di Minno G
* Increased troponin I predicts in-hospital occurrence of hemodynamic instability in patients with sub-massive or non-massive pulmonary embolism independent to clinical, echocardiographic and laboratory information (172 visite)
Int J Cardiol (ISSN: 0167-5273, 1874-1754electronic, 0167-5273linking), 2008 Mar 14; 124(3): 351-357.
Impact Factor: 3.121
Dettagli    Esporta in BibTeX    Esporta in EndNote

Calabrese V, Mancuso C, Calvani M, Rizzarelli E, Butterfield DA, Stella AM
* Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity (302 visite)
Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775.
Impact Factor: 24.52
Dettagli    Esporta in BibTeX    Esporta in EndNote

Ragno R, Simeoni S, Castellano S, Vicidomini C, Mai A, Caroli A, Tramontano A, Bonaccini C, Trojer P, Bauer I, Brosch G, Sbardella G
* Small molecule inhibitors of histone arginine methyltransferases: Homology modeling, molecular docking, binding mode analysis, and biological evaluations (264 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2007 Mar 22; 50(6): 1241-1253.
Impact Factor: 4.895
Dettagli    Esporta in BibTeX    Esporta in EndNote

D'Auria S, Varriale A, Gonnelli M, Saviano M, Staiano M, Rossi M, Strambini GB
* Tryptophan phosphorescence studies of the D-galactose/ D-glucose-binding protein from Escherichia coli provide a molecular portrait with structural and dynamics features of the protein (445 visite)
J Proteome Res (ISSN: 1535-3893), 2007; 6(4): 1306-1312.
Impact Factor: 5.675
Dettagli    Esporta in BibTeX    Esporta in EndNote

D'Andrea LD, Del Gatto A, Pedone C, Benedetti E
* Peptide-based molecules in angiogenesis (312 visite)
Chem Biol Drug Des Chemical Biology And Drug Design (ISSN: 1747-0277, 1747-0285), 2006 Feb; 67(2): 115-126.
Impact Factor: 2.507
Dettagli    Esporta in BibTeX    Esporta in EndNote

Cittadini A, Monti MG, Iaccarino G, Di Rella F, Tsichlis PN, Di Gianni A, Strömer H, Sorriento D, Peschle C, Trimarco B, Saccà L, Condorelli G
* Adenoviral gene transfer of Akt enhances myocardial contractility and intracellular calcium handling (184 visite)
Gene Ther (ISSN: 0969-7128, 0969-7128linking), 2006; 13(1): 8-19.
Impact Factor: 4.782
Dettagli    Esporta in BibTeX    Esporta in EndNote

Colao A, Di Somma C, Cuocolo A, Spinelli L, Acampa W, Spiezia S, Rota F, Savanelli MC, Lombardi G
* Does a gender-related effect of growth hormone (GH) replacement exist on cardiovascular risk factors, cardiac morphology, and performance and atherosclerosis? Results of a two-year open, prospective study in young adult men and women with severe GH deficiency (231 visite)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2005 Sep; 90(9): 5146-5155.
Impact Factor: 6.02
Dettagli    Esporta in BibTeX    Esporta in EndNote

Di Costanzo L, Geremia S, Randaccio L, Nastri F, Maglio O, Lombardi A, Pavone V
* Miniaturized heme proteins: crystal structure of Co(III)-mimochrome IV (197 visite)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2004 Dec; 9(8): 1017-1027.
Impact Factor: 3.3
Dettagli    Esporta in BibTeX    Esporta in EndNote

Colao A, Di Somma C, Cuocolo A, Filippella M, Rota F, Acampa W, Savastano S, Salvatore M, Lombardi G
* The severity of growth hormone deficiency correlates with the severity of cardiac impairment in 100 adult patients with hypopituitarism: An observational, case-control study (167 visite)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2004 Dec; 89(12): 5998-6004.
Impact Factor: 5.778
Dettagli    Esporta in BibTeX    Esporta in EndNote

Galdiero S, Gouaux E
* High Resolution Crystallographic Studies Of Alpha-Hemolysin-Phospholipid Complexes Define Heptamer-Lipid Head Group Interactions: Implication For Understanding Protein-Lipid Interactions (198 visite)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 2004 Jun; 13(6): 1503-1511.
Impact Factor: 4.116
Dettagli    Esporta in BibTeX    Esporta in EndNote

Iaccarino G, Ciccarelli M, Sorriento D, Cipolletta E, Cerullo V, Iovino GL, Paudice A, Elia A, Santulli G, Campanile A, Arcucci O, Pastore L, Salvatore F, Condorelli G, Trimarco B
* AKT participates in endothelial dysfunction in hypertension (188 visite)
Circulationcirculation (ISSN: 0009-7322), 2004; 109(21): 2587-2593.
Impact Factor: 12.563
Dettagli    Esporta in BibTeX    Esporta in EndNote

Vitagliano L, Ruggiero A, Masullo M, Cantiello P, Arcari P, Zagari A
* The Crystal Structure Of Sulfolobus Solfataricus Elongation Factor 1 Alpha In Complex With Magnesium And Gdp (289 visite)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2004; 43(21): 6630-6636.
Impact Factor: 4.008
Dettagli    Esporta in BibTeX    Esporta in EndNote

Spinelli L, Petretta M, Verderame G, Carbone G, Venetucci AA, Petretta A, Acampa W, Bonaduce D, Colao A, Cuocolo A
* Left ventricular diastolic function and cardiac performance during exercise in patients with acromegaly (242 visite)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2003 Sep; 88(9): 4105-4109.
Impact Factor: 5.873
Dettagli    Esporta in BibTeX    Esporta in EndNote

De Luca S, Ulhaq S, Dixon M J, EssexJ, Bradley M
* Solid-phase synthesis of a focused library of trypanothione reductase inhibitors (212 visite)
Tetrahedron Lett (ISSN: 0040-4039), 2003 Apr 7; 44(15): 3195-3197.
Impact Factor: 2.326
Dettagli    Esporta in BibTeX    Esporta in EndNote

Colao A, Marzullo P, Cuocolo A, Spinelli L, Pivonello R, Bonaduce D, Salvatore M, Lombardi G
* Reversal of acromegalic cardiomyopathy in young but not in middle-aged patients after 12 months of treatment with the depot long-acting somatostatin analogue octreotide (231 visite)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 2003 Feb; 58(2): 169-176.
Impact Factor: 2.767
Dettagli    Esporta in BibTeX    Esporta in EndNote

Leosco D, Iaccarino G, Cipolletta E, De Santis D, Pisani E, Trimarco V, Ferrara N, Abete P, Sorriento D, Rengo F, Trimarco B
* Exercise restores β-adrenergic vasorelaxation in aged rat carotid arteries (177 visite)
Am J Physiol Heart Circ Physiol American Journal Of Physiology Heart And Circulatory Physiology (ISSN: 0363-6135), 2003; 285(154-1): H369-H369.
Impact Factor: 3.658
Dettagli    Esporta in BibTeX    Esporta in EndNote

Esposito G, Ligresti A, Izzo AA, Bisogno T, Ruvo M, Di Rosa M, Di Marzo V, Iuvone T
* The endocannabinoid system protects rat glioma cells against HIV-1 Tat protein-induced cytotoxicity: Mechanism and regulation (264 visite)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2002 Dec 27; 277(52): 50348-50354.
Impact Factor: 6.696
Dettagli    Esporta in BibTeX    Esporta in EndNote

Esposito G, Vitagliano L, Santamaria R, Viola A, Zagari A, Salvatore F
* Structural and functional analysis of aldolase B mutants related to hereditary fructose intolerance (198 visite)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2002 Nov 6; 531(2): 152-156.
Impact Factor: 3.912
Dettagli    Esporta in BibTeX    Esporta in EndNote

Colao A, Spinelli L, Cuocolo A, Spiezia S, Pivonello R, Di Somma C, Bonaduce D, Salvatore M, Lombardi G
* Cardiovascular consequences of early-onset growth hormone excess (216 visite)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2002 Jul; 87(7): 3097-3104.
Impact Factor: 5.199
Dettagli    Esporta in BibTeX    Esporta in EndNote

Colao A, Di Somma C, Pivonello R, Cuocolo A, Spinelli L, Bonaduce D, Salvatore M, Lombardi G
* The cardiovascular risk of adult GH deficiency (GHD) improved after GH replacement and worsened in untreated GHD: A 12-month prospective study (193 visite)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2002 Mar; 87(3): 1088-1093.
Impact Factor: 5.199
Dettagli    Esporta in BibTeX    Esporta in EndNote

Colao A, Di Somma C, Cuocolo A, Spinelli L, Tedesco N, Pivonello R, Bonaduce D, Salvatore M, Lombardi G
* Improved cardiovascular risk factors and cardiac performance after 12 months of growth hormone (GH) replacement in young adult patients, with GH deficiency (189 visite)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2001 May; 86(5): 1874-1881.
Impact Factor: 5.16
Dettagli    Esporta in BibTeX    Esporta in EndNote

Colao A, Cuocolo A, Marzullo P, Nicolai E, Ferone D, Morte A, Pivonello R, Salvatore M, Lombardi G
* Is the acromegalic cardiomyopathy reversible? Effect of 5-year normalization of growth hormone and insulin-like growth factor I levels on cardiac performance (159 visite)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2001 Apr; 86(4): 1551-1557.
Impact Factor: 5.16
Dettagli    Esporta in BibTeX    Esporta in EndNote

Colao A, Marzullo P, Ferone D, Spinelli L, Cuocolo A, Bonaduce D, Salvatore M, Boerlin V, Lancranjan I, Lombardi G
Cardiovascular effects of depot long-acting somatostatin analog sandostatin LAR in acromegaly (195 visite)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2000 Sep; 85(9): 3132-3140.
Impact Factor: 5.447
Dettagli    Esporta in BibTeX    Esporta in EndNote

Marzullo P, Cuocolo A, Ferone D, Pivonello R, Salvatore M, Lombardi G, Colao A
Cardiac effect of thyrotoxicosis in acromegaly (182 visite)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2000 Apr; 85(4): 1426-1432.
Impact Factor: 5.447
Dettagli    Esporta in BibTeX    Esporta in EndNote

Colao A, Cuocolo A, Di Somma C, Cerbone G, Della Morte A, Pivonello R, Nicolai E, Salvatore M, Lombardi G
Does the age of onset of growth hormone deficiency affect cardiac performance? A radionuclide angiography study (156 visite)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 2000 Apr; 52(4): 447-455.
Impact Factor: 2.922
Dettagli    Esporta in BibTeX    Esporta in EndNote

Colao A, Cuocolo A, Di Somma C, Cerbone G, Della Morte A, Nicolai E, Lucci R, Salvatore M, Lombardi G
Impaired cardiac performance in elderly patients with growth hormone deficiency (161 visite)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1999 Nov; 84(11): 3950-3955.
Impact Factor: 5.805
Dettagli    Esporta in BibTeX    Esporta in EndNote

Colao A, Cuocolo A, Marzullo P, Nicolai E, Ferone D, Della Morte A, Petretta M, Salvatore M, Lombardi G
Impact of patient's age and disease duration on cardiac performance in acromegaly: A radionuclide angiography study (159 visite)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1999 May; 84(5): 1518-1523.
Impact Factor: 5.805
Dettagli    Esporta in BibTeX    Esporta in EndNote

Colao A, Lastoria S, Ferone D, Varrella P, Marzullo P, Pivonello R, Cerbone G, Acampa W, Salvatore M, Lombardi G
The pituitary uptake of In-111-DTPA-D-Phe(1)-octreotide in the normal pituitary and in pituitary adenomas (218 visite)
J Endocrinol Invest (ISSN: 0391-4097, 1720-8386electronic), 1999 Mar; 22(3): 176-183.
Impact Factor: 0.957
Dettagli    Esporta in BibTeX    Esporta in EndNote

Colao A, Cuocolo A, Marzullo P, Nicolai E, Ferone D, Florimonte L, Salvatore M, Lombardi G
Effects of 1-year treatment with octreotide on cardiac performance in patients with acromegaly (179 visite)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1999 Jan; 84(1): 17-23.
Impact Factor: 5.805
Dettagli    Esporta in BibTeX    Esporta in EndNote

Lombardi A, De Simone G, Nastri F, Galdiero S, Della Morte R, Staiano N, Pedone C, Bolognesi M, Pavone V
The Crystal Structure Of Alpha-Thrombin-Hirunorm Iv Complex Reveals A Novel Specificity Site Recognition Mode (256 visite)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 1999 Jan; 8(1): 91-95.
Impact Factor: 4.457
Dettagli    Esporta in BibTeX    Esporta in EndNote

Longobardi S, Cuocolo A, Merola B, Di Rella F, Colao A, Nicolai E, Cardei S, Salvatore M, Lombardi G
Left ventricular function in young adults with childhood and adulthood onset growth hormone deficiency (168 visite)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 1998 Feb; 48(2): 137-143.
Impact Factor: 3.101
Dettagli    Esporta in BibTeX    Esporta in EndNote

Ferone D, Lastoria S, Colao A, Varrella P, Cerbone G, Acampa W, Merola B, Salvatore M, Lombardi G
Correlation of scintigraphic results using 123I-methoxybenzamide with hormone levels and tumor size response to quinagolide in patients with pituitary adenomas (171 visite)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1998 Jan; 83(1): 248-252.
Impact Factor: 5.641
Dettagli    Esporta in BibTeX    Esporta in EndNote

Lombardi G, Colao A, Cuocolo A, Longobardi S, Di Somma C, Orio F, Merola B, Nicolai E, Salvatore M
Cardiological aspects of growth hormone and insulin-like growth factor- (200 visite)
J Pediatr Endocrinol Metab (ISSN: 0334-018x), 1997 Nov; 10(6): 553-560.
Impact Factor: 0.481
Dettagli    Esporta in BibTeX    Esporta in EndNote

Sijens PE, Knopp MV, Brunetti A, Wicklow K, Alfano B, Bachert P, Sanders JA, Stillman AE, Kett H, Sauter R
1H MR spectroscopy in patients with metastatic brain tumors: A multicenter study (194 visite)
Magn Reson Med (ISSN: 0740-3194, 1522-2594electronic), 1995 Jun; 33(6): 818-826.
Impact Factor: 3.012
Dettagli    Esporta in BibTeX    Esporta in EndNote



75 Records (71 escludendo Abstract e Conferenze).
Impact factor totale: 358.546 (342.202 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 328.99 (314.592 escludendo Abstract e Conferenze).







    Esporta in BibTeX    Esporta in EndNote

Ultima modifica di Marco Comerci in data Thursday 19 March 2015, 12:24:54
262 visite. Ultima visita in data Monday 30 March 2020, 14:01:26