Home Ricerca Sedi Chi siamo Organigramma Personale Contatti Didattica Login Documenti EN
Progetti in evidenza
INCIPIT
(Link esterno)

ISTAPCA
(1209 visite)

Fondo Europeo Pesca
(622 visite)

Euro-BioImaging
(Link esterno)

Fondazione Veronesi
(Link esterno)

LightDyNAmics
(1094 visite)

 INMiND
(1186 visite)

Instruct-IT
(Link esterno)

 PRIN
(1329 visite)

 eHealthNet
(1090 visite)

Ponrec
(1028 visite)

MFAG Grant
(1134 visite)

MERIT
(Link esterno)


Collegamenti

Contiene: [X]      Estesa     Autori: [X]  Tipo di lavoro: [X]   Data iniziale: Data finale: [X]      Sede: Affiliazione IBB     
    
[Pulisci modulo]


Cationic porphyrins are reversible proteasome inhibitors (154 visite)

Santoro AM, Lo Giudice MC, D'Urso A, Lauceri R, Purrello R, Milardi D

J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2012 Jun 27; 134(25): 10451-10457.



Tipo di articolo: Journal Article, Research Support, Non-U. S. Gov'T,

Impact factor: 10.677, Impact factor a 5 anni: 10.237

Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84863490720&partnerID=40&md5=504f1817a8bdc96bcee859fd239e8b72

Parole chiave: Anticancer Properties, Axial Coordination, Cationic Porphyrin, Central Metals, Inhibition Activity, Inhibition Assays, Inhibitory Effect, Macrocycles, Metalloporphyrins, Micromolar Range, Molecular Levels, Peptidase Activity, Protease Activities, Proteasome Inhibitors, Spectroscopic Characterization, Uv-Vis Spectra, Water-Soluble Porphyrin, Dyes, Metal Ions, Scaffolds, Anion, Antineoplastic Agent, Cationic Porphyrin Derivative, Macrocyclic Compound, Proteinase, Unclassified Drug, Amino Terminal Sequence, Article, Canonical Analysis, Cell Assay, Controlled Study, Drug Activity, Drug Effect, Drug Efficacy, Drug Protein Binding, Drug Structure, Drug Targeting, Enzyme Activity, Human, Human Cell, Molecular Docking, Protein Structure, Protein Subunit, Static Electricity, Ultraviolet Radiation, Enzyme Activation, Enzyme Inhibitors, Hela Cells, Models, Proteasome Endopeptidase Complex, Cations Pharmacology, Enzyme Activation Drug Effects, Enzyme Inhibitors Pharmacology, Porphyrins Pharmacology,

Affiliazioni:

*** IBB - CNR ***
IBB-CNR, Istituto di Biostrutture e Bioimmagini, UOS di Catania C/o Dipartimento di Scienze Chimiche, Viale A. Doria 6, 95125 Catania, Italy
ISE-CNR, Istituto per Lo Studio Degli Ecosistemi, Largo Tonolli, 50, 28922 Verbania Pallanza (VB), Italy
Department of Periodontology and Biomaterials, Radboud University Nijmegen Medical Center, Philips van Leydenlaan 25, 6525 EX Nijmegen, Netherlands



Riferimenti:

Maiti, N.C., Mazumdar, S., Periasamy, N., (1998) J. Phys. Chem. B, 102, pp. 1528-153

Lauceri, R., Raudino, A., Monsù Scolaro, L., Micali, N., Purrello, R., (2002) J. Am. Chem. Soc., 124, pp. 894-895

Segawa, H., Takehara, C., Honda, K., Shimidzu, T., Asahi, T., Mataga, N., (1992) J. Phys. Chem., 2, pp. 503-506

Pasternack, R.F., Francesconi, L., Raff, D., Spiro, E., (1973) Inorg. Chem., 11, pp. 2606-2611

Pasternack, R.F., Gibbs, E.J., Villafranca, J.J., (1983) Biochemistry, 22, pp. 2406-2414

D'Urso, A., Holmes, A.E., Berova, N., Balaz, M., Purrello, R., (2011) Chem. Asian J., 6, pp. 3104-3109

Shohei, S., Atsuhiro, O., (2011) Angew Chem. Int., 50, pp. 4342-4373

Dougherty, T.J., Gomer, C.J., Henderson, B.W., Jori, G., (1998) J. Natl. Cancer. Inst., 90, pp. 889-905

Pandey, R.K., Zheng, G., (2000) The Porphyrin Handbook, 6, pp. 157-230. , In

Kadish, K. M. Smith, K. M. Guilard, R. Academic Press, Boston

Celli, J.P., Spring, B.Q., Rizvi, I., Evans, C.L., Samkoe, K.S., Verma, S., Pogue, B.W., Hasan, T., (2010) Chem. Rev., 110, pp. 2795-2838

Barth, R.F., Coderre, J.A., Vicente, M.G., Blue, T.E., (2005) Clin. Cancer Res., 11, pp. 3987-4002

Soloway, A.H., Tjarks, W., Barnum, B.A., Rong, F.G., Barth, R.F., Codogni, I.M., Wilson, J.G., (1998) Chem. Rev., 98, pp. 1515-1562

Dixon, I.M., Lopez, F., Estève, J.P., Tejera, A.M., Blasco, M.A., Pratviel, G., Meunier, B., (2005) Chembiochem., 6, pp. 123-132

Harley, C.B., Futcher, A.B., Greider, C.W., (1990) Nature, 345, pp. 458-460

Mergny, J.L., Riou, J.F., Mailliet, P., (2002) Nucleic Acids Res., 30, pp. 839-865

Szokalska, A., Makowski, M., Nowis, D., Wilczynski, G.M., Kujawa, M., Wójcik, C., Młynarczuk-Biały, I., Golab, J., (2009) Cancer Res., 69, pp. 4235-4243

Gallastegui, N., Groll, M., (2010) Trends Biochem. Sci., 35, pp. 634-642

Hershko, A., Ciechanover, A., (1998) Annu. Rev. Biochem., 67, pp. 425-479

Pickart, C.M., Cohen, R.E., (2004) Nat. Rev. Mol. Cell Biol., 5, pp. 177-187

Coux, O., Tanaka, K., Goldberg, A.L., (1996) Annu. Rev. Biochem., 65, pp. 810-847

Kisselev, A.F., Callard, A., Goldberg, A.L., (2006) J. Biol. Chem., 281, pp. 8582-8590

Matsuo, Y., Sawai, H., Ochi, N., Yasuda, A., Sakamoto, M., Takahashi, H., Funahashi, H., Guha, S., (2010) Dig. Dis. Sci., 55, pp. 1167-1176

Adams, J., (2004) Cancer Cell., 5, pp. 417-421

Crawford, L.J., Walker, B., Ovaa, H., Chauhan, D., Anderson, K.C., Morris, T.C., Irvine, A.E., (2006) Cancer Res., 66, pp. 6379-6386

Milardi, D., Arnesano, F., Grasso, G., Magrì, A., Tabbì, G., Scintilla, S., Natile, G., Rizzarelli, E., (2007) Angew. Chem Int. Ed., 46, pp. 7993-7995

Arena, G., Fattorusso, R., Grasso, G., Grasso, G.I., Isernia, C., Malgieri, G., Milardi, D., Rizzarelli, E., (2011) Chem.-Eur. J., 17, pp. 11596-11603

Demo, S.D., Kirk, C.J., Aujay, M.A., Buchholz, T.J., Dajee, M., Ho, M.N., Jiang, J., Bennett, M.K., (2007) Cancer Res., 67, pp. 6383-6391

Herrmansn, O., Ehdi, H.U., Orsin, A., (1978) Can. J. Chem., 56, pp. 1084-1087

Rodgers, K.J., Dean, R.T., (2003) Int. J. Biochem. Cell. Biol., 35, pp. 716-727

Copeland, R.A., (2005) Evaluation of Enzyme Inhibitors in Drug Discovery

Methods of Biochemical Analysis, p. 46. , In

Wiley Press: Hoboken, NJ

Trott, O., Olson, A.J., (2010) J. Comput. Chem., 31, pp. 455-461

Huey, R., Morris, G.M., Olson, A.J., Goodsell, D.S., (2007) J. Comput. Chem., 28, pp. 1145-1152

Dewar, M.J.S., Zoebisch, E.G., Healy, E.F., Stewart, J.J.P., (1985) J. Am. Chem. Soc., 107, pp. 3902-3909

De Bettignies, G., Coux, O., (2010) Biochimie, 92, pp. 1530-1545

Portero-Otín, M., Pamplona, R., Ruiz, M.C., Cabiscol, E., Prat, J., Bellmunt, M., (1999) J. Diabetes, 48, pp. 2215-2220

McNaught, K.S., Olanow, C.W., Halliwell, B., Isacson, O., Jenner, P., (2001) Nat. Rev. Neur., 2, pp. 589-594

Gaczynska, M., Rock, K.L., Spies, T., Goldberg, A.L., (1994) Proc. Natl. Acad. Sci. U.S.A., 91, pp. 9213-9217

Kisselev, A.F., Garcia-Calvo, M., Overkleeft, H.S., Peterson, E., Pennington, M.W., Ploegh, H.L., Thornberry, N.A., Goldberg, A.L., (2003) J. Biol. Chem., 278, pp. 35869-35877

Fenteany, G., Standaert, R.F., Lane, W.S., Choi, S., Corey, E.J., Schreiber, S.L., (1995) Science, 268, pp. 726-731

Stauch, B., Simon, B., Basile, T., Schneider, G., Malek, N.P., Kalesse, M., Carlomagno, T., (2010) Angew. Chem., 122, pp. 4026-4030

Parkinson, G.N., Ghosh, R., Neidle, S., (2007) Biochemistry, 46, pp. 2390-2397

Giordano, S., Petrelli, A., (2008) Curr. Med. Chem., 15, pp. 422-432

McMillin, D.R., Shelton, A.H., Bejune, S.A., Fanwick, P.E., Wall, R.K., (2005) Coord. Chem. Rev., 249, pp. 1451-1459

Mita, H., Ohyama, T., Tanaka, Y., Yamamoto, Y., (2006) Biochemistry, 45, pp. 6765-6772

Wang, K., Zhang, Z., Wu, L., Li, Z.-Y., (2007) Chem. Biodiv, pp. 514-522

Jia, G., Feng, Z., Wei, C., Zhou, J., Wang, X., Li, C., (2009) J. Phys. Chem.B, 113, pp. 16237-16245

Kornguth, S.E., Kalinke, T., Robins, H.I., Cohen, J.D., Turski, P., (1989) Cancer Res., 49, pp. 6390-6395

Dick, L.R., Fleming, P.E., (2010) Drug Discov. Today, 15, pp. 243-249

Blackburn, C., Gigstad, K.M., Hales, P., Garcia, K., Jones, M., Bruzzese, F.J., Barrett, C., Blank, J.L., (2010) Biochem. J., 430, pp. 461-476

Maiti, N. C., Mazumdar, S., Periasamy, N., (1998) J. Phys. Chem. B, 102, pp. 1528-153

Pasternack, R. F., Francesconi, L., Raff, D., Spiro, E., (1973) Inorg. Chem., 11, pp. 2606-2611

Pasternack, R. F., Gibbs, E. J., Villafranca, J. J., (1983) Biochemistry, 22, pp. 2406-2414

Dougherty, T. J., Gomer, C. J., Henderson, B. W., Jori, G., (1998) J. Natl. Cancer. Inst., 90, pp. 889-905

Pandey, R. K., Zheng, G., (2000) The Porphyrin Handbook, 6, pp. 157-230. , In

Celli, J. P., Spring, B. Q., Rizvi, I., Evans, C. L., Samkoe, K. S., Verma, S., Pogue, B. W., Hasan, T., (2010) Chem. Rev., 110, pp. 2795-2838

Barth, R. F., Coderre, J. A., Vicente, M. G., Blue, T. E., (2005) Clin. Cancer Res., 11, pp. 3987-4002

Soloway, A. H., Tjarks, W., Barnum, B. A., Rong, F. G., Barth, R. F., Codogni, I. M., Wilson, J. G., (1998) Chem. Rev., 98, pp. 1515-1562

Dixon, I. M., Lopez, F., Est ve, J. P., Tejera, A. M., Blasco, M. A., Pratviel, G., Meunier, B., (2005) Chembiochem., 6, pp. 123-132

Harley, C. B., Futcher, A. B., Greider, C. W., (1990) Nature, 345, pp. 458-460

Mergny, J. L., Riou, J. F., Mailliet, P., (2002) Nucleic Acids Res., 30, pp. 839-865

Pickart, C. M., Cohen, R. E., (2004) Nat. Rev. Mol. Cell Biol., 5, pp. 177-187

Kisselev, A. F., Callard, A., Goldberg, A. L., (2006) J. Biol. Chem., 281, pp. 8582-8590

Crawford, L. J., Walker, B., Ovaa, H., Chauhan, D., Anderson, K. C., Morris, T. C., Irvine, A. E., (2006) Cancer Res., 66, pp. 6379-6386

Demo, S. D., Kirk, C. J., Aujay, M. A., Buchholz, T. J., Dajee, M., Ho, M. N., Jiang, J., Bennett, M. K., (2007) Cancer Res., 67, pp. 6383-6391

Rodgers, K. J., Dean, R. T., (2003) Int. J. Biochem. Cell. Biol., 35, pp. 716-727

Copeland, R. A., (2005) Evaluation of Enzyme Inhibitors in Drug Discovery

Dewar, M. J. S., Zoebisch, E. G., Healy, E. F., Stewart, J. J. P., (1985) J. Am. Chem. Soc., 107, pp. 3902-3909

Portero-Ot n, M., Pamplona, R., Ruiz, M. C., Cabiscol, E., Prat, J., Bellmunt, M., (1999) J. Diabetes, 48, pp. 2215-2220

McNaught, K. S., Olanow, C. W., Halliwell, B., Isacson, O., Jenner, P., (2001) Nat. Rev. Neur., 2, pp. 589-594

Kisselev, A. F., Garcia-Calvo, M., Overkleeft, H. S., Peterson, E., Pennington, M. W., Ploegh, H. L., Thornberry, N. A., Goldberg, A. L., (2003) J. Biol. Chem., 278, pp. 35869-35877

Parkinson, G. N., Ghosh, R., Neidle, S., (2007) Biochemistry, 46, pp. 2390-2397

McMillin, D. R., Shelton, A. H., Bejune, S. A., Fanwick, P. E., Wall, R. K., (2005) Coord. Chem. Rev., 249, pp. 1451-1459

Kornguth, S. E., Kalinke, T., Robins, H. I., Cohen, J. D., Turski, P., (1989) Cancer Res., 49, pp. 6390-6395

Dick, L. R., Fleming, P. E., (2010) Drug Discov. Today, 15, pp. 243-249



The aim of this study is to verify if water-soluble porphyrins can be used as proteasome inhibitors. We have found that cationic porphyrins inhibit proteasome peptidase activities much more effectively than the corresponding anionic derivatives. The relevance of electrostatics in driving porphyin-proteasome interactions has been confirmed by the observation that the inhibitory efficiency of the cationic macrocycles decreases with the number of positive substituents. We have also investigated various metalloporphyrins, which differ due to the different propension of the central metal ion toward axial coordination. Our experimental results indicate that the naked cationic porphyrins are the most active in reversibly inhibiting the three main protease activities of the proteasome in the micromolar range. A spectroscopic characterization of porphyrin-proteasome interactions by UV-vis spectra parallels the results of inhibition assays: the higher the inhibitory effect the stronger the spectroscopic variations are. To interpret the action of porphyrins at a molecular level, we have performed calculations evidencing that cationic porphyrins may hinder the access to the canonical proteolytic site on the proteasome β5 subunit. In particular, an inspection of the top-scoring docking modes shows that the tetracationic porphyrin blocks the catalytic pocket, close to the N termini of the β5 proteasome subunit, more efficiently than its anionic counterpart. Proteasome inhibition activity of porphyrins unites their known anticancer properties making them suitable as a scaffold for the design of novel multitargeted molecules. © 2012 American Chemical Society.
Nessun risultato.

Contiene: [X]      Estesa     Autori: [X]  Tipo di lavoro: [X]   Data iniziale: Data finale: [X]      Sede: Affiliazione IBB     
    
[Pulisci modulo]


Chino M, Zhang SQ, Pirro F, Leone L, Maglio O, Lombardi A, Degrado WF
* Spectroscopic and metal binding properties of a de novo metalloprotein binding a tetrazinc cluster (36 visite)
Biopolymers (ISSN: 1097-0282electronic, 0006-3525linking, 0006-3525print), 2018 Sep 11; 109(10): e23339-e23339.
Impact Factor: 2.572
Dettagli    Esporta in BibTeX    Esporta in EndNote

Oliveri V, Lanza V, Milardi D, Viale M, Maric I, Sgarlata C, Vecchio G
* Amino- and chloro-8-hydroxyquinolines and their copper complexes as proteasome inhibitors and antiproliferative agents (56 visite)
Metallomics (ISSN: 1756-591xelectronic, 1756-5901linking), 2017 Oct 18; 9(10): 1439-1446.
Impact Factor: 4.099
Dettagli    Esporta in BibTeX    Esporta in EndNote

Tomasello MF, Nardon C, Lanza V, Di Natale G, Pettenuzzo N, Salmaso S, Milardi D, Caliceti P, Pappalardo G, Fregona D
* New comprehensive studies of a gold(III) Dithiocarbamate complex with proven anticancer properties: Aqueous dissolution with cyclodextrins, pharmacokinetics and upstream inhibition of the ubiquitin-proteasome pathway (103 visite)
Eur J Med Chem (ISSN: 1768-3254electronic, 0223-5234linking), 2017 Jun 19; 138: 115-127.
Impact Factor: 4.519
Dettagli    Esporta in BibTeX    Esporta in EndNote

Gaglione R, Pirone L, Farina B, Fusco S, Smaldone G, Aulitto M, Dell'Olmo E, Roscetto E, Del Gatto A, Fattorusso R, Notomista E, Zaccaro L, Arciello A, Pedone E, Contursi P
* Insights into the anticancer properties of the first antimicrobial peptide from Archaea (80 visite)
Biochim Biophys Acta (ISSN: 0006-3002print, 0006-3002linking, 0005-2728), 2017 Jun 15; 1861(9): 2155-2164.
Impact Factor: 4.932
Dettagli    Esporta in BibTeX    Esporta in EndNote

Santoro AM, Cunsolo A, D'Urso A, Sbardella D, Tundo GR, Ciaccio C, Coletta M, Diana D, Fattorusso R, Persico M, Di Dato A, Fattorusso C, Milardi D, Purrello R
* Cationic porphyrins are tunable gatekeepers of the 20S proteasome (473 visite) (PDF 145 visite)
Chem Sci (ISSN: 2041-6539, 2041-6520, 2041-6520linking), 2016; 7(2): 1286-1297.
Impact Factor: 8.668
Dettagli    Esporta in BibTeX    Esporta in EndNote

Mollica A, Locatelli M, Macedonio G, Carradori S, Sobolev AP, De Salvador RF, Monti SM, Buonanno M, Zengin G, Angeli A, Supuran CT
* Microwave-assisted extraction, HPLC analysis, and inhibitory effects on carbonic anhydrase I, II, VA, and VII isoforms of 14 blueberry Italian cultivars (101 visite)
J Enzyme Inhib Med Chem, 2016; 31(sup4): N/D-N/D.
Impact Factor: 3.428
Dettagli    Esporta in BibTeX    Esporta in EndNote

Palladino P, Aura AM, Spoto G
* Surface plasmon resonance for the label-free detection of Alzheimer's β-amyloid peptide aggregation (161 visite)
Analytical And Bioanalytical Chemistry (ISSN: 1618-2642), 2016; 408(3): 849-854.
Impact Factor: 3.431
Dettagli    Esporta in BibTeX    Esporta in EndNote

Sandomenico A, Celentano V, D'Andrea LD, Palmieri G, Ruvo M
* Screening of beta-hairpin peptide-engrafted 1, 2, 3-triazoles to identify APEH enzyme inhibitors (104 visite)
Rsc Adv (ISSN: 2046-2069), 2015; 5(13): 9965-9972.
Impact Factor: 3.289
Dettagli    Esporta in BibTeX    Esporta in EndNote

Engelen M, Lombardi A, Vitale R, Lista L, Maglio O, Pavone V, Nastri F
* Branched porphyrins as functional scaffolds for multisite bioconjugation (92 visite)
Biotechnol Appl Biochem (ISSN: 1470-8744electronic, 0885-4513linking), 2014 Sep 21; N/D: N/D-N/D.
Impact Factor: 1.362
Dettagli    Esporta in BibTeX    Esporta in EndNote

Mercurio FA, Marasco D, Pirone L, Pedone E, Pellecchia M,  Leone M
* Solution Structure of the First Sam Domain of Odin and Binding Studies with the EphA2 Receptor (118 visite)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2012 Mar 13; 51(10): 2136-2145.
Impact Factor: 3.377
Dettagli    Esporta in BibTeX    Esporta in EndNote

Esposito L, Ruggiero A, Masullo M, Ruocco MR, Lamberti A, Arcari P, Zagari A, Vitagliano L
* Crystallographic and spectroscopic characterizations of Sulfolobus solfataricus TrxA1 provide insights into the determinants of thioredoxin fold stability (118 visite)
Journal Of Structural Biology (ISSN: 1047-8477), 2012 Feb; 177(2): 506-512.
Impact Factor: 3.361
Dettagli    Esporta in BibTeX    Esporta in EndNote

Diana D, Basile A, De Rosa L, Di Stasi R, Auriemma S, Arra C, Pedone C, Turco MC, Fattorusso R, D'Andrea LD
* Beta-Hairpin Peptide That Targets Vascular Endothelial Growth Factor (vegf) Receptors: Design, Nmr Characterization, And Biological Activity (161 visite)
J Biol Chem Journal Of Biological Chemistry (ISSN: 1083-351x, 0021-9258), 2011 Dec 2; 286(48): 41680-41691.
Impact Factor: 4.773
Dettagli    Esporta in BibTeX    Esporta in EndNote

Tabbì G, Di Mauro G, Purrello R, Bonomo RP
* Electrochemical characterization of ordered arrays of metallo-porphyrins in aqueous solution (123 visite)
Dalton Trans (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2011 Apr 28; 40(16): 4223-4229.
Impact Factor: 3.838
Dettagli    Esporta in BibTeX    Esporta in EndNote

Grasso G, Pietropaolo A, Spoto G, Pappalardo G, Tundo GR, Ciaccio C, Coletta M, Rizzarelli E
* Copper(I) and Copper(II) Inhibit A beta Peptides Proteolysis by Insulin-Degrading Enzyme Differently: Implications for Metallostasis Alteration in Alzheimer's Disease (168 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Feb 25; 17(9): 2752-2762.
Impact Factor: 5.925
Dettagli    Esporta in BibTeX    Esporta in EndNote

Cucinotta V, Giuffrida A, Grasso G, MacCarrone G, Mazzaglia A, Messina M, Vecchio G
* Diaminotrehalose-capped β-cyclodextrin, a new member of hemispherodextrins: Synthesis, thermodynamic and spectroscopic characterization and its exploitation in chiral electrokinetic chromatography (110 visite)
J Sep Sci (ISSN: 1615-9306), 2011 Jan; 34(1): 70-76.
Impact Factor: 2.733
Dettagli    Esporta in BibTeX    Esporta in EndNote

Vergara A, Vitagliano L, Merlino A, Sica F, Marino K, Verde C, di Prisco G, Mazzarella L
* An Order-Disorder Transition Plays a Role in Switching Off the Root Effect in Fish Hemoglobins (109 visite)
J Biol Chem Journal Of Biological Chemistry (ISSN: 0021-9258, 1083-351x), 2010 Oct 15; 285(42): 32568-32575.
Impact Factor: 5.328
Dettagli    Esporta in BibTeX    Esporta in EndNote

Torres Martin De Rosales R, Faiella M, Farquhar E, Que L, J , Andreozzi C, Pavone V, Maglio O, Nastri F, Lombardi A
* Spectroscopic and metal-binding properties of DF3: an artificial protein able to accommodate different metal ions (91 visite)
J Biol Inorg Chem (ISSN: 1432-1327electronic, 0949-8257linking, 0949-8257print), 2010 Jun; 15(5): 717-728.
Impact Factor: 3.287
Dettagli    Esporta in BibTeX    Esporta in EndNote

Puglisi A, Rizzarelli E, Vecchio G, Iacovino R, Benedetti E, Pedone C, Saviano M
* Crystal And Molecular Structure Of Beta-Cyclodextrins Functionalized With The Anti-Inflammatory Drug Etodolac (143 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2009 Dec; 91(12): 1227-1235.
Impact Factor: 2.605
Dettagli    Esporta in BibTeX    Esporta in EndNote

Attanasio F, Cataldo S, Fisichella S, Nicoletti S, Nicoletti VG, Pignataro B, Savarino A, Rizzarelli E
* Protective effects of L- and D-carnosine on alpha-crystallin amyloid fibril formation: implications for cataract disease (120 visite)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2009 Jul 14; 48(27): 6522-6531.
Impact Factor: 3.226
Dettagli    Esporta in BibTeX    Esporta in EndNote

Vitagliano L, Vergara A, Bonomi G, Merlino A, Verde C, Di Prisco G, Howes BD, Smulevich G, Mazzarella L
* Spectroscopic and crystallographic characterization of a tetrameric hemoglobin oxidation reveals structural features of the functional intermediate relaxed/tense state (118 visite)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2008 Sep 13; 130(32): 10527-10535.
Impact Factor: 8.091
Dettagli    Esporta in BibTeX    Esporta in EndNote

Impellizzeri G, La Mendola D, Magrì A, Maccarrone G, Pappalardo G, Rizzarelli E
* Spectroscopic characterization of PEG-amylin derivatives (105 visite)
Understanding Biology Using Peptides, 2006; N/D: N/D-N/D.
Impact Factor: 2.614
Dettagli    Esporta in BibTeX    Esporta in EndNote

La Mendola D, Magrì A, Pappalardo G, Impellizzeri G, Maccarrone G, Rizzarelli E
* Spectroscopic characterization of PEG amylin derivatives (107 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2005; 80(4): N/D-N/D.
Impact Factor: 2.545
Dettagli    Esporta in BibTeX    Esporta in EndNote

Lauceri R, Raudino A, Scolaro LM, Micali N, Purrello R
* From achiral porphyrins to template-imprinted chiral aggregates and further. Self-replication of chiral memory from scratch (121 visite)
J Am Chem Soc (ISSN: 0002-7863print, 0002-7863linking, 1520-5126electronic), 2002 Feb 13; 120(47): 894-895.
Impact Factor: 9.023
Dettagli    Esporta in BibTeX    Esporta in EndNote

Vinci C, Caltabiano V, Santoro AM, Rabuazzo AM, Buscema M, Purrello R, Rizzarelli E, Vigneri R, Purrello F
Copper Addition Prevents The Inhibitory Effects Of Interleukin 1-Beta On Rat Pancreatic Islets (103 visite)
Diabetologia, 1995 Jan; 38(1): 39-45.
Impact Factor: 0
Dettagli    Esporta in BibTeX    Esporta in EndNote

Bonomo RP, Bonsignore F, Conte E, Impellizzeri G, Pappalardo G, Purrello R, Rizzarelli E
Thermodynamic and Spectroscopic Characterization, and in vitro O2- Scavenger Activity of Copper(II) Complexes with Glycyl-L-histidyl-glycyl-L-histidine (103 visite)
J Chem Soc (ISSN: 1364-5447), 1993; 8: 1295-1300.
Impact Factor: 0
Dettagli    Esporta in BibTeX    Esporta in EndNote



25 Records (23 escludendo Abstract e Conferenze).
Impact factor totale: 97.026 (91.867 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 98.412 (93.185 escludendo Abstract e Conferenze).







    Esporta in BibTeX    Esporta in EndNote

Ultima modifica di Marco Comerci in data Thursday 19 March 2015, 12:58:02
154 visite. Ultima visita in data Friday 01 February 2019, 2:44:13

Webmaster and developer: Marco Comerci
Per problemi e suggerimenti: adminibb.cnr.it
Ultimo aggiornamento: Monday 18 February 2019, 17:23:40