Appropriate use criteria for amyloid PET imaging cannot replace guidelines: on behalf of the European Association of Nuclear Medicine
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Appropriate use criteria for amyloid PET imaging cannot replace guidelines: on behalf of the European Association of Nuclear Medicine (174 visite)

Booij J, Arbizu J, Darcourt J, Hesse S, Nobili F, Payoux P, Pappata S, Tatsch K, Walker Z, Pagani M

Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2013 Jul; 40(7): 1122-1125.



Tipo di articolo: Journal Article, Comment, Editorial,

Impact factor: 5.217, Impact factor a 5 anni: 4.728

Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84879502551&partnerID=40&md5=fee8ebd5cdb69a2ac9a7a0782b3b93f1

Parole chiave: Amyloid Beta-Peptides Metabolism, Brain Metabolism Radionuclide Imaging, Humans, Positron-Emission Tomography Methods, Amyloid Beta Protein, Florbetaben, Florbetapir F 18, Flutemetamol F 18, Pittsburgh Compound B, Alzheimer Disease, Brain Perfusion, Cerebrospinal Fluid Analysis, Clinical Practice, Cost Effectiveness Analysis, Dementia, Diffuse Lewy Body Disease, Disease Course, Disease Severity, Dopaminergic System, Early Diagnosis, Food And Drug Administration, Health Care Personnel, Medical Society, Mild Cognitive Impairment, Molecular Imaging, Pathogenesis, Positron Emission Tomography, Practice Guideline, Review, Risk Benefit Analysis, Risk Factor,

Affiliazioni:

*** IBB - CNR ***
Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
Nuclear Medicine Department, Clinica Universidad de Navarra, University of Navarra, Pamplona, Spain
Clinical Neurophysiology, Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Genoa, Italy
INSERM, Toulouse, France
Institute of Biostructure and Bioimaging, CNR, Naples, Italy
Department of Mental Health Sciences Unit, University College London, London, United Kingdom
Institute of Cognitive Sciences and Technologies, CNR, Rome, Italy


Riferimenti:

Johnson, K.A., Minoshima, S., Bohnen, N.I., Donohoe, K.J., Foster, N.L., Herscovitch, P., Appropriate use criteria for amyloid PET: A report of the Amyloid Imaging Task Force, the Society of Nuclear Medicine and Molecular Imaging, and the Alzheimer's Association (2013) J Nucl Med, 54, pp. 476-490. , 23359661 10.2967/jnumed.113.120618 1:CAS:528:DC%2BC3sXltV2ks7g%3

Klunk, W.E., Engler, H., Nordberg, A., Wang, Y., Blomqvist, G., Holt, D.P., Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B (2004) Ann Neurol, 55, pp. 306-319. , 14991808 10.1002/ana.20009 1:CAS:528:DC%2BD2cXisFKntb8%3D

Kemppainen, N.M., Aalto, S., Wilson, I.A., Någren, K., Helin, S., Brück, A., Voxel-based analysis of PET amyloid ligand [11C]PIB uptake in Alzheimer disease (2006) Neurology, 67, pp. 1575-1580. , 16971697 10.1212/01.wnl.0000240117.55680.0a 1:STN:280: DC%2BD28nmslagsQ%3D%3D

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Edison, P., Rowe, C.C., Rinne, J.O., Ng, S., Ahmed, I., Kemppainen, N., Amyloid load in Parkinson's disease dementia and Lewy body dementia measured with [11C]PIB positron emission tomography (2008) J Neurol Neurosurg Psychiatry, 79, pp. 1331-1338. , 18653550 10.1136/jnnp.2007.127878 1:STN:280:DC%2BD1cjktFSgsg%3D%3D

Gomperts, S.N., Rentz, D.M., Moran, E., Becker, J.A., Locascio, J.J., Klunk, W.E., Imaging amyloid deposition in Lewy body diseases (2008) Neurology, 71, pp. 903-910. , 18794492 10.1212/01.wnl.0000326146.60732.d6 1:STN:280: DC%2BD1cngs1amtw%3D%3D

Chételat, G., Villemagne, V.L., Bourgeat, P., Pike, K.E., Jones, G., Ames, D., Relationship between atrophy and beta-amyloid deposition in Alzheimer disease (2010) Ann Neurol, 67, pp. 317-324. , 20373343

Santillo, A.F., Gambini, J.P., Lannfelt, L., Långström, B., Ulla-Marja, L., Kilander, L., In vivo imaging of astrocytosis in Alzheimer's disease: An 11C-L-deuteriodeprenyl and PIB PET study (2011) Eur J Nucl Med Mol Imaging, 38, pp. 2202-2208. , 21853308 10.1007/s00259-011-1895-9

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Tolboom, N., Yaqub, M., Boellaard, R., Luurtsema, G., Windhorst, A.D., Scheltens, P., Test-retest variability of quantitative [11C]PIB studies in Alzheimer's disease (2009) Eur J Nucl Med Mol Imaging, 36, pp. 1629-1638. , 19384547 10.1007/s00259-009-1129-6

Engler, H., Santillo, A.F., Wang, S.X., Lindau, M., Savitcheva, I., Nordberg, A., In vivo amyloid imaging with PET in frontotemporal dementia (2008) Eur J Nucl Med Mol Imaging, 35, pp. 100-106. , 17846768 10.1007/s00259-007-0523-1

Bacskai, B.J., Frosch, M.P., Freeman, S.H., Raymond, S.B., Augustinack, J.C., Johnson, K.A., Molecular imaging with Pittsburgh Compound B confirmed at autopsy: A case report (2007) Arch Neurol, 64, pp. 431-434. , 17353389 10.1001/archneur.64.3.431

Ikonomovic, M.D., Klunk, W.E., Abrahamson, E.E., Mathis, C.A., Price, J.C., Tsopelas, N.D., Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease (2008) Brain, 131, pp. 1630-1645. , 18339640 10.1093/brain/awn016

Ikonomovic, M.D., Abrahamson, E.E., Price, J.C., Hamilton, R.L., Mathis, C.A., Paljug, W.R., Early AD pathology in a [C-11]PiB-negative case: A PiB-amyloid imaging, biochemical, and immunohistochemical study (2012) Acta Neuropathol., 123, pp. 433-447. , 22271153 10.1007/s00401-012-0943-2 1:CAS:528:DC%2BC38Xisl2ktbk%3D

Rowe, C.C., Ackerman, U., Browne, W., Mulligan, R., Pike, K.L., O'Keefe, G., Imaging of amyloid ß in Alzheimer's disease with 18F-BAY94-9172, a novel PET tracer: Proof of mechanism (2008) Lancet Neurol, 7, pp. 129-135. , 18191617 10.1016/S1474-4422(08)70001-2 1:CAS:528:DC%2BD1cXis1WmsLw%3D

Koole, M., Lewis, D.M., Buckley, C., Nelissen, N., Vandenbulcke, M., Brooks, D.J., Whole-body biodistribution and radiation dosimetry of 18F-GE067: A radioligand for in vivo brain amyloid imaging (2009) J Nucl Med, 50, pp. 818-822. , 19372469 10.2967/jnumed.108.060756 1:CAS:528:DC%2BD1MXmtV2hsrk%3D

Wong, D.F., Rosenberg, P.B., Zhou, Y., Kumar, A., Raymont, V., Ravert, H.T., In vivo imaging of amyloid deposition in Alzheimer disease using the radioligand 18F-AV-45 (florbetapir F 18) (2010) J Nucl Med, 51, pp. 913-920. , 20501908 10.2967/jnumed.109.069088 1:CAS:528:DC%2BC3cXosl2ksb4%3D

Clark, C.M., Schneider, J.A., Bedell, B.J., Beach, T.G., Bilker, W.B., Mintun, M.A., Use of florbetapir-PET for imaging beta-amyloid pathology (2011) JAMA, 305, pp. 275-283. , 21245183 10.1001/jama.2010.2008 1:CAS:528:DC%2BC3MXhtVGrurw%3D

Barthel, H., Gertz, H.J., Dresel, S., Peters, O., Bartenstein, P., Buerger, K., Cerebral amyloid-ß PET with florbetaben (18F) in patients with Alzheimer's disease and healthy controls: A multicentre phase 2 diagnostic study (2011) Lancet Neurol, 10, pp. 424-435. , 21481640 10.1016/S1474-4422(11)70077-1 1:CAS:528:DC%2BC3MXlt1Sls7c%3D

Cselényi, Z., Jönhagen, M.E., Forsberg, A., Halldin, C., Julin, P., Schou, M., Clinical validation of 18F-AZD4694, an amyloid-ß-specific PET radioligand (2012) J Nucl Med, 53, pp. 415-424. , 22323782 10.2967/jnumed.111.094029

Clark, C.M., Pontecorvo, M.J., Beach, T.G., Bedell, B.J., Coleman, R.E., Doraiswamy, P.M., Cerebral PET with florbetapir compared with neuropathology at autopsy for detection of neuritic amyloid-ß plaques: A prospective cohort study (2012) Lancet Neurol, 11, pp. 669-678. , 22749065 10.1016/S1474-4422(12)70142-4 1:CAS:528:DC%2BC38XhtV2gtb3E

Rinne, J.O., Wong, D.F., Wolk, D.A., Leinonen, V., Arnold, S.E., Buckley, C., [18F]Flutemetamol PET imaging and cortical biopsy histopathology for fibrillar amyloid ß detection in living subjects with normal pressure hydrocephalus: Pooled analysis of four studies (2012) Acta Neuropathol, 124, pp. 833-845. , 23053137 10.1007/s00401-012-1051-z 1:CAS:528:DC%2BC38XhslKls7zI

Okello, A., Koivunen, J., Edison, P., Archer, H.A., Turkheimer, F.E., Någren, K., Conversion of amyloid positive and negative MCI to AD over 3 years: An 11C-PIB PET study (2009) Neurology, 73, pp. 754-760. , 19587325 10.1212/WNL.0b013e3181b23564 1:CAS:528:DC%2BD1MXhtVKrsbvF

Koivunen, J., Scheinin, N., Virta, J.R., Aalto, S., Vahlberg, T., Någren, K., Amyloid PET imaging in patients with mild cognitive impairment: A 2-year follow-up study (2011) Neurology, 76, pp. 1085-1090. , 21325653 10.1212/WNL.0b013e318212015e 1:STN:280:DC%2BC3M3ot1Klsg%3D%3D

Morris, J.C., Price, J.L., Pathologic correlates of nondemented aging, mild cognitive impairment, and early-stage Alzheimer's disease (2001) J Mol Neurosci, 17, pp. 101-118. , 11816784 10.1385/JMN:17:2:101 1:CAS:528:DC%2BD3MXosVKitrg%3D

Varrone, A., Asenbaum, S., Vander Borght, T., Booij, J., Nobili, F., Någren, K., EANM procedure guidelines for PET brain imaging using [18F]FDG, version 2 (2009) Eur J Nucl Med Mol Imaging, 36, pp. 2103-2110. , 19838705 10.1007/s00259-009-1264-0

Kapucu, O.L., Nobili, F., Varrone, A., Booij, J., Vander Borght, T., Någren, K., EANM procedure guideline for brain perfusion SPECT using 99mTc-labelled radiopharmaceuticals, version 2 (2009) Eur J Nucl Med Mol Imaging, 36, pp. 2093-2102. , 19838703 10.1007/s00259-009-1266-y 1:CAS:528:DC%2BD1MXhsVCisb3L

Van Laere, K., Varrone, A., Booij, J., Vander Borght, T., Nobili, F., Kapucu, O.L., EANM procedure guidelines for brain neurotransmission SPECT/PET using dopamine D2 receptor ligands, version 2 (2010) Eur J Nucl Med Mol Imaging, 37, pp. 434-442. , 19838704 10.1007/s00259-009-1265-z 1:CAS:528:DC%2BC3cXhsVyisL0%3D

Darcourt, J., Booij, J., Tatsch, K., Varrone, A., Vander Borght, T., Kapucu, O.L., EANM procedure guidelines for brain neurotransmission SPECT using 123I-labelled dopamine transporter ligands, version 2 (2010) Eur J Nucl Med Mol Imaging, 37, pp. 443-450. , 19838702 10.1007/s00259-009-1267-x 1:CAS:528:DC%2BC3cXhsVyitr0%3D

Patel, M.R., Spertus, J.A., Brindis, R.G., Hendel, R.C., Douglas, P.S., Peterson, E.D., ACCF proposed method for evaluating the appropriateness of cardiovascular imaging (2005) J Am Coll Cardiol, 46, pp. 1606-1613. , 16226195 10.1016/j.jacc.2005.08.030

Delbeke, D., Chiti, A., Christian, P., Darcourt, J., Donohoe, K., Flotats, A., SNMMI/EANM guideline for guideline development 6.0 (2012) J Nucl Med Technol, 40, pp. 283-289. , 22743147 10.2967/jnmt.112.108787

Dubois, B., Feldman, H.H., Jacova, C., Cummings, J.L., Dekosky, S.T., Barberger-Gateau, P., Revising the definition of Alzheimer's disease: A new lexicon (2010) Lancet Neurol, 9, pp. 1118-1127. , 20934914 10.1016/S1474-4422(10)70223-4

Advisory Committee Briefing Document. New Drug Application 202-008: Amyvid (Florbetapir F 18 Injection), , http://www.fda.gov/downloads/AdvisoryCommittees/ CommitteesMeetingMaterials/Drugs/ PeripheralandCentralNervousSystemDrugsAdvisoryCommittee/UCM240265.pdf, Food and Drug Administration

Fleisher, A.S., Chen, K., Quiroz, Y.T., Jakimovich, L.J., Gomez, M.G., Langois, C.M., Florbetapir PET analysis of amyloid-ß deposition in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: A cross-sectional study (2012) Lancet Neurol, 11, pp. 1057-1065. , 23137949 10.1016/S1474-4422(12)70227-2 1:CAS:528:DC%2BC38Xhs12gt7%2FO

Villemagne, V.L., Pike, K.E., Chételat, G., Ellis, K.A., Mulligan, R.S., Bourgeat, P., Longitudinal assessment of Aß and cognition in aging and Alzheimer disease (2011) Ann Neurol, 69, pp. 181-192. , 21280088 10.1002/ana.22248 1:CAS:528:DC%2BC3MXisVCisLs%3D

Ossenkoppele, R., Prins, N.D., Pijnenburg, Y.A., Lemstra, A.W., Van Der Flier, W.M., Adriaanse, S.F., Impact of molecular imaging on the diagnostic process in a memory clinic (2012) Alzheimers Dement, , 10.1016/j.jalz.2012.07.003 23164552

Grundman, M., Pontecorvo, M.J., Salloway, S.P., Doraiswamy, P.M., Fleisher, A.S., Sadowsky, C.H., Potential impact of amyloid imaging on diagnosis and intended management in patients with progressive cognitive decline (2013) Alzheimer Dis Assoc Disord, 27, pp. 4-15. , 23203162 10.1097/WAD.0b013e318279d02a 1:CAS:528:DC%2BC3sXis12rsLk%3D

Chételat, G., Alzheimer disease: Aß-independent processes-rethinking preclinical AD (2013) Nat Rev Neurol, , 10.1038/nrneurol.2013.21

Johnson, K. A., Minoshima, S., Bohnen, N. I., Donohoe, K. J., Foster, N. L., Herscovitch, P., Appropriate use criteria for amyloid PET: A report of the Amyloid Imaging Task Force, the Society of Nuclear Medicine and Molecular Imaging, and the Alzheimer's Association (2013) J Nucl Med, 54, pp. 476-490. , 23359661 10. 2967/jnumed. 113. 120618 1: CAS: 528: DC%2BC3sXltV2ks7g%3

Klunk, W. E., Engler, H., Nordberg, A., Wang, Y., Blomqvist, G., Holt, D. P., Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B (2004) Ann Neurol, 55, pp. 306-319. , 14991808 10. 1002/ana. 20009 1: CAS: 528: DC%2BD2cXisFKntb8%3D

Kemppainen, N. M., Aalto, S., Wilson, I. A., N gren, K., Helin, S., Br ck, A., Voxel-based analysis of PET amyloid ligand [11C] PIB uptake in Alzheimer disease (2006) Neurology, 67, pp. 1575-1580. , 16971697 10. 1212/01. wnl. 0000240117. 55680. 0a 1: STN: 280: DC%2BD28nmslagsQ%3D%3D

Gomperts, S. N., Rentz, D. M., Moran, E., Becker, J. A., Locascio, J. J., Klunk, W. E., Imaging amyloid deposition in Lewy body diseases (2008) Neurology, 71, pp. 903-910. , 18794492 10. 1212/01. wnl. 0000326146. 60732. d6 1: STN: 280: DC%2BD1cngs1amtw%3D%3D

Ch telat, G., Villemagne, V. L., Bourgeat, P., Pike, K. E., Jones, G., Ames, D., Relationship between atrophy and beta-amyloid deposition in Alzheimer disease (2010) Ann Neurol, 67, pp. 317-324. , 20373343

Santillo, A. F., Gambini, J. P., Lannfelt, L., L ngstr m, B., Ulla-Marja, L., Kilander, L., In vivo imaging of astrocytosis in Alzheimer's disease: An 11C-L-deuteriodeprenyl and PIB PET study (2011) Eur J Nucl Med Mol Imaging, 38, pp. 2202-2208. , 21853308 10. 1007/s00259-011-1895-9

Bacskai, B. J., Frosch, M. P., Freeman, S. H., Raymond, S. B., Augustinack, J. C., Johnson, K. A., Molecular imaging with Pittsburgh Compound B confirmed at autopsy: A case report (2007) Arch Neurol, 64, pp. 431-434. , 17353389 10. 1001/archneur. 64. 3. 431

Ikonomovic, M. D., Klunk, W. E., Abrahamson, E. E., Mathis, C. A., Price, J. C., Tsopelas, N. D., Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease (2008) Brain, 131, pp. 1630-1645. , 18339640 10. 1093/brain/awn016

Ikonomovic, M. D., Abrahamson, E. E., Price, J. C., Hamilton, R. L., Mathis, C. A., Paljug, W. R., Early AD pathology in a [C-11] PiB-negative case: A PiB-amyloid imaging, biochemical, and immunohistochemical study (2012) Acta Neuropathol., 123, pp. 433-447. , 22271153 10. 1007/s00401-012-0943-2 1: CAS: 528: DC%2BC38Xisl2ktbk%3D

Rowe, C. C., Ackerman, U., Browne, W., Mulligan, R., Pike, K. L., O'Keefe, G., Imaging of amyloid in Alzheimer's disease with 18F-BAY94-9172, a novel PET tracer: Proof of mechanism (2008) Lancet Neurol, 7, pp. 129-135. , 18191617 10. 1016/S1474-4422 (08) 70001-2 1: CAS: 528: DC%2BD1cXis1WmsLw%3D

Wong, D. F., Rosenberg, P. B., Zhou, Y., Kumar, A., Raymont, V., Ravert, H. T., In vivo imaging of amyloid deposition in Alzheimer disease using the radioligand 18F-AV-45 (florbetapir F 18) (2010) J Nucl Med, 51, pp. 913-920. , 20501908 10. 2967/jnumed. 109. 069088 1: CAS: 528: DC%2BC3cXosl2ksb4%3D

Clark, C. M., Schneider, J. A., Bedell, B. J., Beach, T. G., Bilker, W. B., Mintun, M. A., Use of florbetapir-PET for imaging beta-amyloid pathology (2011) JAMA, 305, pp. 275-283. , 21245183 10. 1001/jama. 2010. 2008 1: CAS: 528: DC%2BC3MXhtVGrurw%3D

Csel nyi, Z., J nhagen, M. E., Forsberg, A., Halldin, C., Julin, P., Schou, M., Clinical validation of 18F-AZD4694, an amyloid- -specific PET radioligand (2012) J Nucl Med, 53, pp. 415-424. , 22323782 10. 2967/jnumed. 111. 094029

Clark, C. M., Pontecorvo, M. J., Beach, T. G., Bedell, B. J., Coleman, R. E., Doraiswamy, P. M., Cerebral PET with florbetapir compared with neuropathology at autopsy for detection of neuritic amyloid- plaques: A prospective cohort study (2012) Lancet Neurol, 11, pp. 669-678. , 22749065 10. 1016/S1474-4422 (12) 70142-4 1: CAS: 528: DC%2BC38XhtV2gtb3E

Rinne, J. O., Wong, D. F., Wolk, D. A., Leinonen, V., Arnold, S. E., Buckley, C., [18F] Flutemetamol PET imaging and cortical biopsy histopathology for fibrillar amyloid detection in living subjects with normal pressure hydrocephalus: Pooled analysis of four studies (2012) Acta Neuropathol, 124, pp. 833-845. , 23053137 10. 1007/s00401-012-1051-z 1: CAS: 528: DC%2BC38XhslKls7zI

Morris, J. C., Price, J. L., Pathologic correlates of nondemented aging, mild cognitive impairment, and early-stage Alzheimer's disease (2001) J Mol Neurosci, 17, pp. 101-118. , 11816784 10. 1385/JMN: 17: 2: 101 1: CAS: 528: DC%2BD3MXosVKitrg%3D

Kapucu, O. L., Nobili, F., Varrone, A., Booij, J., Vander Borght, T., N gren, K., EANM procedure guideline for brain perfusion SPECT using 99mTc-labelled radiopharmaceuticals, version 2 (2009) Eur J Nucl Med Mol Imaging, 36, pp. 2093-2102. , 19838703 10. 1007/s00259-009-1266-y 1: CAS: 528: DC%2BD1MXhsVCisb3L

Patel, M. R., Spertus, J. A., Brindis, R. G., Hendel, R. C., Douglas, P. S., Peterson, E. D., ACCF proposed method for evaluating the appropriateness of cardiovascular imaging (2005) J Am Coll Cardiol, 46, pp. 1606-1613. , 16226195 10. 1016/j. jacc. 2005. 08. 030

Fleisher, A. S., Chen, K., Quiroz, Y. T., Jakimovich, L. J., Gomez, M. G., Langois, C. M., Florbetapir PET analysis of amyloid- deposition in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: A cross-sectional study (2012) Lancet Neurol, 11, pp. 1057-1065. , 23137949 10. 1016/S1474-4422 (12) 70227-2 1: CAS: 528: DC%2BC38Xhs12gt7%2FO

Villemagne, V. L., Pike, K. E., Ch telat, G., Ellis, K. A., Mulligan, R. S., Bourgeat, P., Longitudinal assessment of A and cognition in aging and Alzheimer disease (2011) Ann Neurol, 69, pp. 181-192. , 21280088 10. 1002/ana. 22248 1: CAS: 528: DC%2BC3MXisVCisLs%3D

Ch telat, G., Alzheimer disease: A -independent processes-rethinking preclinical AD (2013) Nat Rev Neurol, , 10. 1038/nrneurol. 2013. 21



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* Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity (3 visite)
J NAT PROD (ISSN: 0163-3864), 2015; 78(11): 2704-2711.
Impact Factor: 3.662
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Altieri F, Di Stadio CS, Severino V, Sandomenico A, Minopoli G, Miselli G, Di Maro A, Ruvo M, Chambery A, Quagliariello V, Masullo M, Rippa E, Arcari P
* Anti-amyloidogenic property of human gastrokine (182 visite)
BIOCHIMIE (ISSN: 0300-9084), 2014 Nov; 106C: 91-100.
Impact Factor: 2.963
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Iommelli F, De Rosa V, Gargiulo S, Panico M, Monti M, Greco A, Gramanzini M, Ortosecco G, Fonti R, Brunetti A, Del Vecchio S
* Monitoring Reversal of MET-Mediated Resistance to EGFR Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer Using 3 '-Deoxy-3 '-[F-18]-Fluorothymidine Positron Emission Tomography (185 visite)
CLIN CANCER RES (ISSN: 1078-0432), 2014 Sep 15; 20(18): 4806-4815.
Impact Factor: 8.722
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Grasso GI, Arena G, Bellia F, Rizzarelli E, Vecchio G
* Copper(II)-chelating homocarnosine glycoconjugate as a new multifunctional compound (110 visite)
J INORG BIOCHEM (ISSN: 0162-0134), 2014 Feb; 131: 56-63.
Impact Factor: 3.444
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Autiero I, Saviano M, Langella E
* In silico investigation and targeting of amyloid beta oligomers of different size (120 visite)
Mol Biosyst (ISSN: 1742-206x, 1742-2051electronic), 2013 Aug; 9(8): 2118-2124.
Impact Factor: 3.18
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Marotta V, Ramundo V, Camera L, Del Prete M, Fonti R, Esposito R, Palmieri G, Salvatore M, Vitale M, Colao A, Faggiano A
* Sorafenib in advanced iodine-refractory differentiated thyroid cancer: Efficacy, safety and exploratory analysis of role of serum thyroglobulin and FDG-PET (195 visite)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 2013 May; 78(5): 760-767.
Impact Factor: 3.353
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Attanasio F, Convertino M, Magno A, Caflisch A, Corazza A, Haridas H, Esposito G, Cataldo S, Pignataro B, Milardi D, Rizzarelli E
* Carnosine Inhibits Abeta(42) Aggregation By Perturbing The H-Bond Network In And Around The Central Hydrophobic Cluster (194 visite)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2013 Mar 18; 14(5): 583-592.
Impact Factor: 3.06
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Pandini G, Pace V, Copani A, Squatrito S, Milardi D, Vigneri R
* Insulin has multiple antiamyloidogenic effects on human neuronal cells (164 visite)
Endocrinology (ISSN: 0013-7227, 1945-7170), 2013 Jan; 154(1): 375-387.
Impact Factor: 4.644
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Pannuzzo M, Milardi D, Raudino A, Karttunen M, La Rosa C
* Analytical model and multiscale simulations of Aβ peptide aggregation in lipid membranes: Towards a unifying description of conformational transitions, oligomerization and membrane damage (179 visite)
Phys Chem Chem Phys (ISSN: 1463-9076, 1463-3907, 1463-9084electronic), 2013; 15(23): 8940-8951.
Impact Factor: 4.198
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Attanasio F, De Bona P, Cataldo S, Sciacca MFM, Milardi D, Pignataro B, Pappalardo G
* Copper(II) and zinc(II) dependent effects on A beta 42 aggregation: a CD, Th-T and SFM study (160 visite)
New J Chem (ISSN: 1144-0546), 2013; 37(4): 1206-1215.
Impact Factor: 3.159
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Autiero I, Langella E, Saviano M
* Insights Into The Mechanism Of Interaction Between Trehalose-Conjugated Beta-Sheet Breaker Peptides And Aβ(1-42) Fibrils By Molecular Dynamics Simulations (172 visite)
Molecular Biosystems (ISSN: 1742-206x, 1742-2206), 2013; 9(11): 2835-2841.
Impact Factor: 3.18
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Giuffrida ML, Tomasello F, Caraci F, Chiechio S, Nicoletti F, Copani A
* Beta-Amyloid monomer and insulin/IGF-1 signaling in Alzheimer's disease (151 visite)
Mol Neurobiol (ISSN: 0893-7648), 2012 Dec; 46(3): 605-613.
Impact Factor: 5.471
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Grasso G, Giuffrida ML, Rizzarelli E
* Metallostasis And Amyloid Beta-Degrading Enzymes (197 visite)
Metallomics (ISSN: 1756-5901, 1756-591x, 1756-591xelectronic), 2012 Sep; 4(9): 937-949.
Impact Factor: 4.099
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Calafiore M, Copani A, Deng W
* DNA polymerase-β mediates the neurogenic effect of β-amyloid protein in cultured subventricular zone neurospheres (172 visite)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2012 Mar; 90(3): 559-567.
Impact Factor: 2.974
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Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (237 visite)
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
Impact Factor: 3.677
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Damante CA, Ösz K, Nagy Z, Grasso G, Pappalardo G, Rizzarelli E, Sóvágó I
* Zn2+'s ability to alter the distribution of Cu2+ among the available binding sites of A beta(1-16)-polyethylenglycol-ylated peptide: Implications in Alzheimer's disease (117 visite)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2011 Jun 20; 50(12): 5342-5350.
Impact Factor: 4.601
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Corona C, Frazzini V, Silvestri E, Lattanzio R, La Sorda R, Piantelli M, Canzoniero LM, Ciavardelli D, Rizzarelli E, Sensi SL
* Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice (126 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2011 Mar 15; 6(3): e17971-e17971.
Impact Factor: 4.092
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Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (270 visite)
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
Impact Factor: 4.883
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Grasso G, Pietropaolo A, Spoto G, Pappalardo G, Tundo GR, Ciaccio C, Coletta M, Rizzarelli E
* Copper(I) and Copper(II) Inhibit A beta Peptides Proteolysis by Insulin-Degrading Enzyme Differently: Implications for Metallostasis Alteration in Alzheimer's Disease (168 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Feb 25; 17(9): 2752-2762.
Impact Factor: 5.925
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Storto G, Di Giorgio E, De Renzo A, Pizzuti LM, Cerciello G, Nardelli A, Capacchione D, Castaldi E, Ortosecco G, Pace L
* Assessment of metabolic activity by PET-CT with F-18-FDG in patients with T-cell lymphoma (89 visite)
Br J Haematol (ISSN: 0007-1048, 0007-1048linking, 1365-2141electronic), 2010 Oct; 151(2): 195-197.
Impact Factor: 4.942
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Józsa E, Osz K, Kállay C, de Bona P, Damante CA, Pappalardo G, Rizzarelli E, Sóvágó I
* Nickel(ii) and mixed metal complexes of amyloid-β N-terminus (148 visite)
Dalton Trans (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2010 Sep 14; 39(30): 7046-7053.
Impact Factor: 3.647
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Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Pizzuti LM, Lettieri A, Salvatore M
* PET/CT in cancer research: From preclinical to clinical applications (173 visite)
Contrast Media Mol Imaging (ISSN: 1555-4309, 1555-4309linking), 2010 Jul; 5(4): 190-200.
Impact Factor: 4.02
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Storto G, De Renzo A, Pellegrino T, Perna F, De Falco T, Erra P, Nardelli A, Speranza A, Klain M, Rotoli B, Pace L
* Assessment of Metabolic Response to Radioimmunotherapy with (90)Y-Ibritumomab Tiuxetan in Patients with Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma (112 visite)
Radiology (ISSN: 0033-8419, 1527-1315, 0033-8419linking), 2010 Jan; 254(1): 245-252.
Impact Factor: 6.069
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Jozsa E, Hosz K, Kallay C, De Bona P, Damante CA, Pappalardo G, Rizzarelli E, Sovago I
* Nickel (ii) And Mixed Metal Complexes Of Amyloid-B N-Terminus. Results Of Potentiometric And Spectroscopic Studies On The Binary Nickel (ii) And Mixed Metal Nickel (ii)-Copper (ii) And Nickel (ii)-Copper (ii)-Zinc (ii) Complexes Of Peptide Fragments (174 visite)
Dalton Trans (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2010; 39(30): 7046-7053.
Impact Factor: 3.647
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Giuffrida ML, Caraci F, De Bona P, Pappalardo G, Nicoletti F, Rizzarelli E, Copani A
* The monomer state of beta-amyloid: where the Alzheimer's disease protein meets physiology (144 visite)
Rev Neurosci (ISSN: 0334-1763), 2010; 21(2): 83-93.
Impact Factor: 2.047
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Damante CA, Osz K, Nagy Z, Pappalardo G, Grasso G, Impellizzeri G, Rizzarelli E, Sóvágó I
* Metal Loading Capacity Of Abeta N-Terminus: A Combined Potentiometric And Spectroscopic Study Of Zinc (ii) Complexes With Abeta (1-16), Its Short Or Mutated Peptide Fragments And Its Polyethylene Glycol-Ylated Analogue (139 visite)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2009 Nov 2; 48(21): 10405-10415.
Impact Factor: 4.657
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Giuffrida ML, Caraci F, Pignataro B, Cataldo S, De Bona P, Bruno V, Molinaro G, Pappalardo G, Messina A, Palmigiano A, Garozzo D, Nicoletti F, Rizzarelli E, Copani A
* Beta-Amyloid Monomers Are Neuroprotective (204 visite)
J Neurosci (ISSN: 1529-2401, 0270-6474), 2009 Sep 26; 29(34): 10582-10587.
Impact Factor: 3.669
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Zannetti A, Del Vecchio S, Iommelli F, Del Gatto A,  De Luca S, Zaccaro L, Papaccioli A, Sommella J, Panico M, Speranza A, Grieco P, Novellino E, Saviano M, Pedone C, Salvatore M
* Imaging of alpha(v)beta(3) expression by a bifunctional chimeric RGD peptide not cross-reacting with alpha(v)beta(5) (116 visite)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2009 Sep 15; 15(16): 5224-5233.
Impact Factor: 6.747
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Zannetti A, Del Vecchio S, Iommelli F, Del Gatto A, De Luca S, Zaccaro L, Papaccioli A, Sommella J, Panico M, Speranza A, Grieco P, Novellino E, Saviano M, Pedone C, Salvatore M
* Imaging of αvβ3 expression by a bifunctional chimeric RGD peptide not cross-reacting with α vβ5 (147 visite)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2009 Sep 15; 15(16): 5224-5233.
Impact Factor: 6.747
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De Bona P, Giuffrida ML, Caraci F, Copani A, Pignataro B, Attanasio F, Cataldo S, Pappalardo G, Rizzarelli E
* Design And Synthesis Of New Trehalose-Conjugated Pentapeptides As Inhibitors Of Abeta (1-42) Fibrillogenesis And Toxicity (183 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 220-228.
Impact Factor: 1.807
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D'Auria G, Vacatello M, Falcigno L, Paduano L, Mangiapia G, Calvanese L, Gambaretto R, Dettin M, Paolillo L
* Self-assembling properties of ionic-complementary peptides (153 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 210-219.
Impact Factor: 1.807
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Ciaccio C, Tundo GR, Grasso G, Spoto G, Marasco D, Ruvo M, Gioia M, Rizzarelli E, Coletta M
* Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity (135 visite)
J Mol Biol (ISSN: 1089-8638, 0022-2836, 1089-8638electronic), 2009 Feb 6; 385(5): 1556-1567.
Impact Factor: 3.871
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Caraci F, Busceti C, Biagioni F, Aronica E, Mastroiacovo F, Cappuccio I, Battaglia G, Bruno V, Caricasole A, Copani A, Nicoletti
* The Wnt antagonist, Dickkopf-1, as a target for the treatment of neurodegenerative disorders (91 visite)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2008 Dec; 33(12): 2401-2406.
Impact Factor: 2.26
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Damante CA, Ösz K, Nagy Z, Pappalardo G, Grasso G, Impellizzeri G, Rizzarelli E, Sóvágó I
* The Metal Loading Ability Of Beta-Amyloid N-Terminus: A Combined Potentiometric And Spectroscopic Study Of Copper (ii) Complexes With Beta-Amyloid (1-16), Its Short Or Mutated Peptide Fragments, And Its Polyethylene Glycol (peg)-Ylated Analogue (130 visite)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2008 Oct 20; 47(20): 9669-9683.
Impact Factor: 4.147
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Caraci F, Battaglia G, Busceti C, Biagioni F, Mastroiacovo F, Bosco P, Drago F, Nicoletti F, Sortino MA, Copani A
* TGF-β1 protects against Aβ-neurotoxicity via the phosphatidylinositol-3-kinase pathway (111 visite)
Neurobiology Of Disease (ISSN: 0969-9961), 2008 May; 30(2): 234-242.
Impact Factor: 4.852
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Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA
* The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (128 visite)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
Impact Factor: 4.823
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Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
* The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (125 visite)
Biochim Biophys Acta (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
Impact Factor: 3.078
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Giuffrida ML, Grasso G, Ruvo M, Pedone C, Saporito A, Marasco D, Pignataro B, Cascio C, Copani A, Rizzarelli E
* Abeta(25-35) And Its C- And/Or N-Blocked Derivatives: Copper Driven Structural Features And Neurotoxicity (157 visite)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Feb 15; 85(3): 623-633.
Impact Factor: 3.268
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Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
* Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (140 visite)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2006; 26(43): 10949-10957.
Impact Factor: 2.117
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Calafiore M, Battaglia G, Zappal A, Trovato-Salinaro E, Caraci F, Caruso M, Vancheri C, Sortino MA, Nicoletti F, Copani A
* Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to β-amyloid (93 visite)
Neurobiol Aging (ISSN: 0197-4580, 1558-1497electronic), 2006; 27(4): 606-613.
Impact Factor: 5.599
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Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G
* Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (107 visite)
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
Impact Factor: 1.995
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Filippo C, Mariangela C, Giuseppina F, Pier Luigi C, Angelo B, Marco C, Giuseppe B, Paolo B, Ferdinando N, Agata C, Maria Angela S
* Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against β-amyloid toxicity (250 visite)
Brain Res (ISSN: 0006-8993), 2005; 1047(1): 30-37.
Impact Factor: 2.296
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Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F
* Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (130 visite)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2004 Jun 30; 24(26): 6021-6027.
Impact Factor: 2.384
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Wiesehan K, Buder K, Linke RP, Patt S, Stoldt M, Unger E, Schmitt B, Bucci E, Willbold D
* Selection of D-amino-acid peptides that bind to Alzheimer's disease amyloid peptide Aβ1-42 by mirror image phage display (165 visite)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003; 4(8): 748-753.
Impact Factor: 3.992
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Aime S, Dastrù W, Gobetto R, Viale A
An NMR study of H(μ-H)Os3(CO)11 (122 visite)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2000; 39(11): 2422-2425.
Impact Factor: 2.712
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52 Records (51 escludendo Abstract e Conferenze).
Impact factor totale: 209.346 (205.254 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 214.94 (210.403 escludendo Abstract e Conferenze).







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