Appropriate use criteria for amyloid PET imaging cannot replace guidelines: on behalf of the European Association of Nuclear Medicine (258 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2013 Jul; 40(7): 1122-1125.
Tipo di articolo: Journal Article, Comment, Editorial,
Impact factor: 5.217, Impact factor a 5 anni: 4.728
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84879502551&partnerID=40&md5=fee8ebd5cdb69a2ac9a7a0782b3b93f1
Parole chiave: Amyloid Beta-Peptides Metabolism, Brain Metabolism Radionuclide Imaging, Humans, Positron-Emission Tomography Methods, Amyloid Beta Protein, Florbetaben, Florbetapir F 18, Flutemetamol F 18, Pittsburgh Compound B, Alzheimer Disease, Brain Perfusion, Cerebrospinal Fluid Analysis, Clinical Practice, Cost Effectiveness Analysis, Dementia, Diffuse Lewy Body Disease, Disease Course, Disease Severity, Dopaminergic System, Early Diagnosis, Food And Drug Administration, Health Care Personnel, Medical Society, Mild Cognitive Impairment, Molecular Imaging, Pathogenesis, Positron Emission Tomography, Practice Guideline, Review, Risk Benefit Analysis, Risk Factor,
Affiliazioni:
*** IBB - CNR ***
Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
Nuclear Medicine Department, Clinica Universidad de Navarra, University of Navarra, Pamplona, Spain
Clinical Neurophysiology, Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Genoa, Italy
INSERM, Toulouse, France
Institute of Biostructure and Bioimaging, CNR, Naples, Italy
Department of Mental Health Sciences Unit, University College London, London, United Kingdom
Institute of Cognitive Sciences and Technologies, CNR, Rome, Italy
Riferimenti:
Johnson, K.A., Minoshima, S., Bohnen, N.I., Donohoe, K.J., Foster, N.L., Herscovitch, P., Appropriate use criteria for amyloid PET: A report of the Amyloid Imaging Task Force, the Society of Nuclear Medicine and Molecular Imaging, and the Alzheimer's Association (2013) J Nucl Med, 54, pp. 476-490. , 23359661 10.2967/jnumed.113.120618 1:CAS:528:DC%2BC3sXltV2ks7g%3
Klunk, W.E., Engler, H., Nordberg, A., Wang, Y., Blomqvist, G., Holt, D.P., Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B (2004) Ann Neurol, 55, pp. 306-319. , 14991808 10.1002/ana.20009 1:CAS:528:DC%2BD2cXisFKntb8%3D
Kemppainen, N.M., Aalto, S., Wilson, I.A., Någren, K., Helin, S., Brück, A., Voxel-based analysis of PET amyloid ligand [11C]PIB uptake in Alzheimer disease (2006) Neurology, 67, pp. 1575-1580. , 16971697 10.1212/01.wnl.0000240117.55680.0a 1:STN:280: DC%2BD28nmslagsQ%3D%3D
Edison, P., Archer, H.A., Hinz, R., Hammers, A., Pavese, N., Tai, Y.F., Amyloid, hypometabolism, and cognition in Alzheimer disease: An [11C]PIB and [18F]FDG PET study (2007) Neurology, 68, pp. 501-508. , 17065593 10.1212/01.wnl.0000244749.20056.d4 1:STN:280: DC%2BD2s%2FpsFymsA%3D%3D
Edison, P., Rowe, C.C., Rinne, J.O., Ng, S., Ahmed, I., Kemppainen, N., Amyloid load in Parkinson's disease dementia and Lewy body dementia measured with [11C]PIB positron emission tomography (2008) J Neurol Neurosurg Psychiatry, 79, pp. 1331-1338. , 18653550 10.1136/jnnp.2007.127878 1:STN:280:DC%2BD1cjktFSgsg%3D%3D
Gomperts, S.N., Rentz, D.M., Moran, E., Becker, J.A., Locascio, J.J., Klunk, W.E., Imaging amyloid deposition in Lewy body diseases (2008) Neurology, 71, pp. 903-910. , 18794492 10.1212/01.wnl.0000326146.60732.d6 1:STN:280: DC%2BD1cngs1amtw%3D%3D
Chételat, G., Villemagne, V.L., Bourgeat, P., Pike, K.E., Jones, G., Ames, D., Relationship between atrophy and beta-amyloid deposition in Alzheimer disease (2010) Ann Neurol, 67, pp. 317-324. , 20373343
Santillo, A.F., Gambini, J.P., Lannfelt, L., Långström, B., Ulla-Marja, L., Kilander, L., In vivo imaging of astrocytosis in Alzheimer's disease: An 11C-L-deuteriodeprenyl and PIB PET study (2011) Eur J Nucl Med Mol Imaging, 38, pp. 2202-2208. , 21853308 10.1007/s00259-011-1895-9
Nordberg, A., Carter, S.F., Rinne, J., Drzezga, A., Brooks, D.J., Vandenberghe, R., A European multicentre PET study of fibrillar amyloid in Alzheimer's disease (2013) Eur J Nucl Med Mol Imaging, 40, pp. 104-114. , 22961445 10.1007/s00259-012-2237-2 1:CAS:528:DC%2BC38XhslyjtrvP
Tolboom, N., Yaqub, M., Boellaard, R., Luurtsema, G., Windhorst, A.D., Scheltens, P., Test-retest variability of quantitative [11C]PIB studies in Alzheimer's disease (2009) Eur J Nucl Med Mol Imaging, 36, pp. 1629-1638. , 19384547 10.1007/s00259-009-1129-6
Engler, H., Santillo, A.F., Wang, S.X., Lindau, M., Savitcheva, I., Nordberg, A., In vivo amyloid imaging with PET in frontotemporal dementia (2008) Eur J Nucl Med Mol Imaging, 35, pp. 100-106. , 17846768 10.1007/s00259-007-0523-1
Bacskai, B.J., Frosch, M.P., Freeman, S.H., Raymond, S.B., Augustinack, J.C., Johnson, K.A., Molecular imaging with Pittsburgh Compound B confirmed at autopsy: A case report (2007) Arch Neurol, 64, pp. 431-434. , 17353389 10.1001/archneur.64.3.431
Ikonomovic, M.D., Klunk, W.E., Abrahamson, E.E., Mathis, C.A., Price, J.C., Tsopelas, N.D., Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease (2008) Brain, 131, pp. 1630-1645. , 18339640 10.1093/brain/awn016
Ikonomovic, M.D., Abrahamson, E.E., Price, J.C., Hamilton, R.L., Mathis, C.A., Paljug, W.R., Early AD pathology in a [C-11]PiB-negative case: A PiB-amyloid imaging, biochemical, and immunohistochemical study (2012) Acta Neuropathol., 123, pp. 433-447. , 22271153 10.1007/s00401-012-0943-2 1:CAS:528:DC%2BC38Xisl2ktbk%3D
Rowe, C.C., Ackerman, U., Browne, W., Mulligan, R., Pike, K.L., O'Keefe, G., Imaging of amyloid ß in Alzheimer's disease with 18F-BAY94-9172, a novel PET tracer: Proof of mechanism (2008) Lancet Neurol, 7, pp. 129-135. , 18191617 10.1016/S1474-4422(08)70001-2 1:CAS:528:DC%2BD1cXis1WmsLw%3D
Koole, M., Lewis, D.M., Buckley, C., Nelissen, N., Vandenbulcke, M., Brooks, D.J., Whole-body biodistribution and radiation dosimetry of 18F-GE067: A radioligand for in vivo brain amyloid imaging (2009) J Nucl Med, 50, pp. 818-822. , 19372469 10.2967/jnumed.108.060756 1:CAS:528:DC%2BD1MXmtV2hsrk%3D
Wong, D.F., Rosenberg, P.B., Zhou, Y., Kumar, A., Raymont, V., Ravert, H.T., In vivo imaging of amyloid deposition in Alzheimer disease using the radioligand 18F-AV-45 (florbetapir F 18) (2010) J Nucl Med, 51, pp. 913-920. , 20501908 10.2967/jnumed.109.069088 1:CAS:528:DC%2BC3cXosl2ksb4%3D
Clark, C.M., Schneider, J.A., Bedell, B.J., Beach, T.G., Bilker, W.B., Mintun, M.A., Use of florbetapir-PET for imaging beta-amyloid pathology (2011) JAMA, 305, pp. 275-283. , 21245183 10.1001/jama.2010.2008 1:CAS:528:DC%2BC3MXhtVGrurw%3D
Barthel, H., Gertz, H.J., Dresel, S., Peters, O., Bartenstein, P., Buerger, K., Cerebral amyloid-ß PET with florbetaben (18F) in patients with Alzheimer's disease and healthy controls: A multicentre phase 2 diagnostic study (2011) Lancet Neurol, 10, pp. 424-435. , 21481640 10.1016/S1474-4422(11)70077-1 1:CAS:528:DC%2BC3MXlt1Sls7c%3D
Cselényi, Z., Jönhagen, M.E., Forsberg, A., Halldin, C., Julin, P., Schou, M., Clinical validation of 18F-AZD4694, an amyloid-ß-specific PET radioligand (2012) J Nucl Med, 53, pp. 415-424. , 22323782 10.2967/jnumed.111.094029
Clark, C.M., Pontecorvo, M.J., Beach, T.G., Bedell, B.J., Coleman, R.E., Doraiswamy, P.M., Cerebral PET with florbetapir compared with neuropathology at autopsy for detection of neuritic amyloid-ß plaques: A prospective cohort study (2012) Lancet Neurol, 11, pp. 669-678. , 22749065 10.1016/S1474-4422(12)70142-4 1:CAS:528:DC%2BC38XhtV2gtb3E
Rinne, J.O., Wong, D.F., Wolk, D.A., Leinonen, V., Arnold, S.E., Buckley, C., [18F]Flutemetamol PET imaging and cortical biopsy histopathology for fibrillar amyloid ß detection in living subjects with normal pressure hydrocephalus: Pooled analysis of four studies (2012) Acta Neuropathol, 124, pp. 833-845. , 23053137 10.1007/s00401-012-1051-z 1:CAS:528:DC%2BC38XhslKls7zI
Okello, A., Koivunen, J., Edison, P., Archer, H.A., Turkheimer, F.E., Någren, K., Conversion of amyloid positive and negative MCI to AD over 3 years: An 11C-PIB PET study (2009) Neurology, 73, pp. 754-760. , 19587325 10.1212/WNL.0b013e3181b23564 1:CAS:528:DC%2BD1MXhtVKrsbvF
Koivunen, J., Scheinin, N., Virta, J.R., Aalto, S., Vahlberg, T., Någren, K., Amyloid PET imaging in patients with mild cognitive impairment: A 2-year follow-up study (2011) Neurology, 76, pp. 1085-1090. , 21325653 10.1212/WNL.0b013e318212015e 1:STN:280:DC%2BC3M3ot1Klsg%3D%3D
Morris, J.C., Price, J.L., Pathologic correlates of nondemented aging, mild cognitive impairment, and early-stage Alzheimer's disease (2001) J Mol Neurosci, 17, pp. 101-118. , 11816784 10.1385/JMN:17:2:101 1:CAS:528:DC%2BD3MXosVKitrg%3D
Varrone, A., Asenbaum, S., Vander Borght, T., Booij, J., Nobili, F., Någren, K., EANM procedure guidelines for PET brain imaging using [18F]FDG, version 2 (2009) Eur J Nucl Med Mol Imaging, 36, pp. 2103-2110. , 19838705 10.1007/s00259-009-1264-0
Kapucu, O.L., Nobili, F., Varrone, A., Booij, J., Vander Borght, T., Någren, K., EANM procedure guideline for brain perfusion SPECT using 99mTc-labelled radiopharmaceuticals, version 2 (2009) Eur J Nucl Med Mol Imaging, 36, pp. 2093-2102. , 19838703 10.1007/s00259-009-1266-y 1:CAS:528:DC%2BD1MXhsVCisb3L
Van Laere, K., Varrone, A., Booij, J., Vander Borght, T., Nobili, F., Kapucu, O.L., EANM procedure guidelines for brain neurotransmission SPECT/PET using dopamine D2 receptor ligands, version 2 (2010) Eur J Nucl Med Mol Imaging, 37, pp. 434-442. , 19838704 10.1007/s00259-009-1265-z 1:CAS:528:DC%2BC3cXhsVyisL0%3D
Darcourt, J., Booij, J., Tatsch, K., Varrone, A., Vander Borght, T., Kapucu, O.L., EANM procedure guidelines for brain neurotransmission SPECT using 123I-labelled dopamine transporter ligands, version 2 (2010) Eur J Nucl Med Mol Imaging, 37, pp. 443-450. , 19838702 10.1007/s00259-009-1267-x 1:CAS:528:DC%2BC3cXhsVyitr0%3D
Patel, M.R., Spertus, J.A., Brindis, R.G., Hendel, R.C., Douglas, P.S., Peterson, E.D., ACCF proposed method for evaluating the appropriateness of cardiovascular imaging (2005) J Am Coll Cardiol, 46, pp. 1606-1613. , 16226195 10.1016/j.jacc.2005.08.030
Delbeke, D., Chiti, A., Christian, P., Darcourt, J., Donohoe, K., Flotats, A., SNMMI/EANM guideline for guideline development 6.0 (2012) J Nucl Med Technol, 40, pp. 283-289. , 22743147 10.2967/jnmt.112.108787
Dubois, B., Feldman, H.H., Jacova, C., Cummings, J.L., Dekosky, S.T., Barberger-Gateau, P., Revising the definition of Alzheimer's disease: A new lexicon (2010) Lancet Neurol, 9, pp. 1118-1127. , 20934914 10.1016/S1474-4422(10)70223-4
Advisory Committee Briefing Document. New Drug Application 202-008: Amyvid (Florbetapir F 18 Injection), , http://www.fda.gov/downloads/AdvisoryCommittees/ CommitteesMeetingMaterials/Drugs/ PeripheralandCentralNervousSystemDrugsAdvisoryCommittee/UCM240265.pdf, Food and Drug Administration
Fleisher, A.S., Chen, K., Quiroz, Y.T., Jakimovich, L.J., Gomez, M.G., Langois, C.M., Florbetapir PET analysis of amyloid-ß deposition in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: A cross-sectional study (2012) Lancet Neurol, 11, pp. 1057-1065. , 23137949 10.1016/S1474-4422(12)70227-2 1:CAS:528:DC%2BC38Xhs12gt7%2FO
Villemagne, V.L., Pike, K.E., Chételat, G., Ellis, K.A., Mulligan, R.S., Bourgeat, P., Longitudinal assessment of Aß and cognition in aging and Alzheimer disease (2011) Ann Neurol, 69, pp. 181-192. , 21280088 10.1002/ana.22248 1:CAS:528:DC%2BC3MXisVCisLs%3D
Ossenkoppele, R., Prins, N.D., Pijnenburg, Y.A., Lemstra, A.W., Van Der Flier, W.M., Adriaanse, S.F., Impact of molecular imaging on the diagnostic process in a memory clinic (2012) Alzheimers Dement, , 10.1016/j.jalz.2012.07.003 23164552
Grundman, M., Pontecorvo, M.J., Salloway, S.P., Doraiswamy, P.M., Fleisher, A.S., Sadowsky, C.H., Potential impact of amyloid imaging on diagnosis and intended management in patients with progressive cognitive decline (2013) Alzheimer Dis Assoc Disord, 27, pp. 4-15. , 23203162 10.1097/WAD.0b013e318279d02a 1:CAS:528:DC%2BC3sXis12rsLk%3D
Chételat, G., Alzheimer disease: Aß-independent processes-rethinking preclinical AD (2013) Nat Rev Neurol, , 10.1038/nrneurol.2013.21
Johnson, K. A., Minoshima, S., Bohnen, N. I., Donohoe, K. J., Foster, N. L., Herscovitch, P., Appropriate use criteria for amyloid PET: A report of the Amyloid Imaging Task Force, the Society of Nuclear Medicine and Molecular Imaging, and the Alzheimer's Association (2013) J Nucl Med, 54, pp. 476-490. , 23359661 10. 2967/jnumed. 113. 120618 1: CAS: 528: DC%2BC3sXltV2ks7g%3
Klunk, W. E., Engler, H., Nordberg, A., Wang, Y., Blomqvist, G., Holt, D. P., Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B (2004) Ann Neurol, 55, pp. 306-319. , 14991808 10. 1002/ana. 20009 1: CAS: 528: DC%2BD2cXisFKntb8%3D
Kemppainen, N. M., Aalto, S., Wilson, I. A., N gren, K., Helin, S., Br ck, A., Voxel-based analysis of PET amyloid ligand [11C] PIB uptake in Alzheimer disease (2006) Neurology, 67, pp. 1575-1580. , 16971697 10. 1212/01. wnl. 0000240117. 55680. 0a 1: STN: 280: DC%2BD28nmslagsQ%3D%3D
Gomperts, S. N., Rentz, D. M., Moran, E., Becker, J. A., Locascio, J. J., Klunk, W. E., Imaging amyloid deposition in Lewy body diseases (2008) Neurology, 71, pp. 903-910. , 18794492 10. 1212/01. wnl. 0000326146. 60732. d6 1: STN: 280: DC%2BD1cngs1amtw%3D%3D
Ch telat, G., Villemagne, V. L., Bourgeat, P., Pike, K. E., Jones, G., Ames, D., Relationship between atrophy and beta-amyloid deposition in Alzheimer disease (2010) Ann Neurol, 67, pp. 317-324. , 20373343
Santillo, A. F., Gambini, J. P., Lannfelt, L., L ngstr m, B., Ulla-Marja, L., Kilander, L., In vivo imaging of astrocytosis in Alzheimer's disease: An 11C-L-deuteriodeprenyl and PIB PET study (2011) Eur J Nucl Med Mol Imaging, 38, pp. 2202-2208. , 21853308 10. 1007/s00259-011-1895-9
Bacskai, B. J., Frosch, M. P., Freeman, S. H., Raymond, S. B., Augustinack, J. C., Johnson, K. A., Molecular imaging with Pittsburgh Compound B confirmed at autopsy: A case report (2007) Arch Neurol, 64, pp. 431-434. , 17353389 10. 1001/archneur. 64. 3. 431
Ikonomovic, M. D., Klunk, W. E., Abrahamson, E. E., Mathis, C. A., Price, J. C., Tsopelas, N. D., Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease (2008) Brain, 131, pp. 1630-1645. , 18339640 10. 1093/brain/awn016
Ikonomovic, M. D., Abrahamson, E. E., Price, J. C., Hamilton, R. L., Mathis, C. A., Paljug, W. R., Early AD pathology in a [C-11] PiB-negative case: A PiB-amyloid imaging, biochemical, and immunohistochemical study (2012) Acta Neuropathol., 123, pp. 433-447. , 22271153 10. 1007/s00401-012-0943-2 1: CAS: 528: DC%2BC38Xisl2ktbk%3D
Rowe, C. C., Ackerman, U., Browne, W., Mulligan, R., Pike, K. L., O'Keefe, G., Imaging of amyloid in Alzheimer's disease with 18F-BAY94-9172, a novel PET tracer: Proof of mechanism (2008) Lancet Neurol, 7, pp. 129-135. , 18191617 10. 1016/S1474-4422 (08) 70001-2 1: CAS: 528: DC%2BD1cXis1WmsLw%3D
Wong, D. F., Rosenberg, P. B., Zhou, Y., Kumar, A., Raymont, V., Ravert, H. T., In vivo imaging of amyloid deposition in Alzheimer disease using the radioligand 18F-AV-45 (florbetapir F 18) (2010) J Nucl Med, 51, pp. 913-920. , 20501908 10. 2967/jnumed. 109. 069088 1: CAS: 528: DC%2BC3cXosl2ksb4%3D
Clark, C. M., Schneider, J. A., Bedell, B. J., Beach, T. G., Bilker, W. B., Mintun, M. A., Use of florbetapir-PET for imaging beta-amyloid pathology (2011) JAMA, 305, pp. 275-283. , 21245183 10. 1001/jama. 2010. 2008 1: CAS: 528: DC%2BC3MXhtVGrurw%3D
Csel nyi, Z., J nhagen, M. E., Forsberg, A., Halldin, C., Julin, P., Schou, M., Clinical validation of 18F-AZD4694, an amyloid- -specific PET radioligand (2012) J Nucl Med, 53, pp. 415-424. , 22323782 10. 2967/jnumed. 111. 094029
Clark, C. M., Pontecorvo, M. J., Beach, T. G., Bedell, B. J., Coleman, R. E., Doraiswamy, P. M., Cerebral PET with florbetapir compared with neuropathology at autopsy for detection of neuritic amyloid- plaques: A prospective cohort study (2012) Lancet Neurol, 11, pp. 669-678. , 22749065 10. 1016/S1474-4422 (12) 70142-4 1: CAS: 528: DC%2BC38XhtV2gtb3E
Rinne, J. O., Wong, D. F., Wolk, D. A., Leinonen, V., Arnold, S. E., Buckley, C., [18F] Flutemetamol PET imaging and cortical biopsy histopathology for fibrillar amyloid detection in living subjects with normal pressure hydrocephalus: Pooled analysis of four studies (2012) Acta Neuropathol, 124, pp. 833-845. , 23053137 10. 1007/s00401-012-1051-z 1: CAS: 528: DC%2BC38XhslKls7zI
Morris, J. C., Price, J. L., Pathologic correlates of nondemented aging, mild cognitive impairment, and early-stage Alzheimer's disease (2001) J Mol Neurosci, 17, pp. 101-118. , 11816784 10. 1385/JMN: 17: 2: 101 1: CAS: 528: DC%2BD3MXosVKitrg%3D
Kapucu, O. L., Nobili, F., Varrone, A., Booij, J., Vander Borght, T., N gren, K., EANM procedure guideline for brain perfusion SPECT using 99mTc-labelled radiopharmaceuticals, version 2 (2009) Eur J Nucl Med Mol Imaging, 36, pp. 2093-2102. , 19838703 10. 1007/s00259-009-1266-y 1: CAS: 528: DC%2BD1MXhsVCisb3L
Patel, M. R., Spertus, J. A., Brindis, R. G., Hendel, R. C., Douglas, P. S., Peterson, E. D., ACCF proposed method for evaluating the appropriateness of cardiovascular imaging (2005) J Am Coll Cardiol, 46, pp. 1606-1613. , 16226195 10. 1016/j. jacc. 2005. 08. 030
Fleisher, A. S., Chen, K., Quiroz, Y. T., Jakimovich, L. J., Gomez, M. G., Langois, C. M., Florbetapir PET analysis of amyloid- deposition in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: A cross-sectional study (2012) Lancet Neurol, 11, pp. 1057-1065. , 23137949 10. 1016/S1474-4422 (12) 70227-2 1: CAS: 528: DC%2BC38Xhs12gt7%2FO
Villemagne, V. L., Pike, K. E., Ch telat, G., Ellis, K. A., Mulligan, R. S., Bourgeat, P., Longitudinal assessment of A and cognition in aging and Alzheimer disease (2011) Ann Neurol, 69, pp. 181-192. , 21280088 10. 1002/ana. 22248 1: CAS: 528: DC%2BC3MXisVCisLs%3D
Ch telat, G., Alzheimer disease: A -independent processes-rethinking preclinical AD (2013) Nat Rev Neurol, , 10. 1038/nrneurol. 2013. 21
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2013 Jul; 40(7): 1122-1125.
Tipo di articolo: Journal Article, Comment, Editorial,
Impact factor: 5.217, Impact factor a 5 anni: 4.728
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84879502551&partnerID=40&md5=fee8ebd5cdb69a2ac9a7a0782b3b93f1
Parole chiave: Amyloid Beta-Peptides Metabolism, Brain Metabolism Radionuclide Imaging, Humans, Positron-Emission Tomography Methods, Amyloid Beta Protein, Florbetaben, Florbetapir F 18, Flutemetamol F 18, Pittsburgh Compound B, Alzheimer Disease, Brain Perfusion, Cerebrospinal Fluid Analysis, Clinical Practice, Cost Effectiveness Analysis, Dementia, Diffuse Lewy Body Disease, Disease Course, Disease Severity, Dopaminergic System, Early Diagnosis, Food And Drug Administration, Health Care Personnel, Medical Society, Mild Cognitive Impairment, Molecular Imaging, Pathogenesis, Positron Emission Tomography, Practice Guideline, Review, Risk Benefit Analysis, Risk Factor,
Affiliazioni:
*** IBB - CNR ***
Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
Nuclear Medicine Department, Clinica Universidad de Navarra, University of Navarra, Pamplona, Spain
Clinical Neurophysiology, Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Genoa, Italy
INSERM, Toulouse, France
Institute of Biostructure and Bioimaging, CNR, Naples, Italy
Department of Mental Health Sciences Unit, University College London, London, United Kingdom
Institute of Cognitive Sciences and Technologies, CNR, Rome, Italy
Riferimenti:
Johnson, K.A., Minoshima, S., Bohnen, N.I., Donohoe, K.J., Foster, N.L., Herscovitch, P., Appropriate use criteria for amyloid PET: A report of the Amyloid Imaging Task Force, the Society of Nuclear Medicine and Molecular Imaging, and the Alzheimer's Association (2013) J Nucl Med, 54, pp. 476-490. , 23359661 10.2967/jnumed.113.120618 1:CAS:528:DC%2BC3sXltV2ks7g%3
Klunk, W.E., Engler, H., Nordberg, A., Wang, Y., Blomqvist, G., Holt, D.P., Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B (2004) Ann Neurol, 55, pp. 306-319. , 14991808 10.1002/ana.20009 1:CAS:528:DC%2BD2cXisFKntb8%3D
Kemppainen, N.M., Aalto, S., Wilson, I.A., Någren, K., Helin, S., Brück, A., Voxel-based analysis of PET amyloid ligand [11C]PIB uptake in Alzheimer disease (2006) Neurology, 67, pp. 1575-1580. , 16971697 10.1212/01.wnl.0000240117.55680.0a 1:STN:280: DC%2BD28nmslagsQ%3D%3D
Edison, P., Archer, H.A., Hinz, R., Hammers, A., Pavese, N., Tai, Y.F., Amyloid, hypometabolism, and cognition in Alzheimer disease: An [11C]PIB and [18F]FDG PET study (2007) Neurology, 68, pp. 501-508. , 17065593 10.1212/01.wnl.0000244749.20056.d4 1:STN:280: DC%2BD2s%2FpsFymsA%3D%3D
Edison, P., Rowe, C.C., Rinne, J.O., Ng, S., Ahmed, I., Kemppainen, N., Amyloid load in Parkinson's disease dementia and Lewy body dementia measured with [11C]PIB positron emission tomography (2008) J Neurol Neurosurg Psychiatry, 79, pp. 1331-1338. , 18653550 10.1136/jnnp.2007.127878 1:STN:280:DC%2BD1cjktFSgsg%3D%3D
Gomperts, S.N., Rentz, D.M., Moran, E., Becker, J.A., Locascio, J.J., Klunk, W.E., Imaging amyloid deposition in Lewy body diseases (2008) Neurology, 71, pp. 903-910. , 18794492 10.1212/01.wnl.0000326146.60732.d6 1:STN:280: DC%2BD1cngs1amtw%3D%3D
Chételat, G., Villemagne, V.L., Bourgeat, P., Pike, K.E., Jones, G., Ames, D., Relationship between atrophy and beta-amyloid deposition in Alzheimer disease (2010) Ann Neurol, 67, pp. 317-324. , 20373343
Santillo, A.F., Gambini, J.P., Lannfelt, L., Långström, B., Ulla-Marja, L., Kilander, L., In vivo imaging of astrocytosis in Alzheimer's disease: An 11C-L-deuteriodeprenyl and PIB PET study (2011) Eur J Nucl Med Mol Imaging, 38, pp. 2202-2208. , 21853308 10.1007/s00259-011-1895-9
Nordberg, A., Carter, S.F., Rinne, J., Drzezga, A., Brooks, D.J., Vandenberghe, R., A European multicentre PET study of fibrillar amyloid in Alzheimer's disease (2013) Eur J Nucl Med Mol Imaging, 40, pp. 104-114. , 22961445 10.1007/s00259-012-2237-2 1:CAS:528:DC%2BC38XhslyjtrvP
Tolboom, N., Yaqub, M., Boellaard, R., Luurtsema, G., Windhorst, A.D., Scheltens, P., Test-retest variability of quantitative [11C]PIB studies in Alzheimer's disease (2009) Eur J Nucl Med Mol Imaging, 36, pp. 1629-1638. , 19384547 10.1007/s00259-009-1129-6
Engler, H., Santillo, A.F., Wang, S.X., Lindau, M., Savitcheva, I., Nordberg, A., In vivo amyloid imaging with PET in frontotemporal dementia (2008) Eur J Nucl Med Mol Imaging, 35, pp. 100-106. , 17846768 10.1007/s00259-007-0523-1
Bacskai, B.J., Frosch, M.P., Freeman, S.H., Raymond, S.B., Augustinack, J.C., Johnson, K.A., Molecular imaging with Pittsburgh Compound B confirmed at autopsy: A case report (2007) Arch Neurol, 64, pp. 431-434. , 17353389 10.1001/archneur.64.3.431
Ikonomovic, M.D., Klunk, W.E., Abrahamson, E.E., Mathis, C.A., Price, J.C., Tsopelas, N.D., Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease (2008) Brain, 131, pp. 1630-1645. , 18339640 10.1093/brain/awn016
Ikonomovic, M.D., Abrahamson, E.E., Price, J.C., Hamilton, R.L., Mathis, C.A., Paljug, W.R., Early AD pathology in a [C-11]PiB-negative case: A PiB-amyloid imaging, biochemical, and immunohistochemical study (2012) Acta Neuropathol., 123, pp. 433-447. , 22271153 10.1007/s00401-012-0943-2 1:CAS:528:DC%2BC38Xisl2ktbk%3D
Rowe, C.C., Ackerman, U., Browne, W., Mulligan, R., Pike, K.L., O'Keefe, G., Imaging of amyloid ß in Alzheimer's disease with 18F-BAY94-9172, a novel PET tracer: Proof of mechanism (2008) Lancet Neurol, 7, pp. 129-135. , 18191617 10.1016/S1474-4422(08)70001-2 1:CAS:528:DC%2BD1cXis1WmsLw%3D
Koole, M., Lewis, D.M., Buckley, C., Nelissen, N., Vandenbulcke, M., Brooks, D.J., Whole-body biodistribution and radiation dosimetry of 18F-GE067: A radioligand for in vivo brain amyloid imaging (2009) J Nucl Med, 50, pp. 818-822. , 19372469 10.2967/jnumed.108.060756 1:CAS:528:DC%2BD1MXmtV2hsrk%3D
Wong, D.F., Rosenberg, P.B., Zhou, Y., Kumar, A., Raymont, V., Ravert, H.T., In vivo imaging of amyloid deposition in Alzheimer disease using the radioligand 18F-AV-45 (florbetapir F 18) (2010) J Nucl Med, 51, pp. 913-920. , 20501908 10.2967/jnumed.109.069088 1:CAS:528:DC%2BC3cXosl2ksb4%3D
Clark, C.M., Schneider, J.A., Bedell, B.J., Beach, T.G., Bilker, W.B., Mintun, M.A., Use of florbetapir-PET for imaging beta-amyloid pathology (2011) JAMA, 305, pp. 275-283. , 21245183 10.1001/jama.2010.2008 1:CAS:528:DC%2BC3MXhtVGrurw%3D
Barthel, H., Gertz, H.J., Dresel, S., Peters, O., Bartenstein, P., Buerger, K., Cerebral amyloid-ß PET with florbetaben (18F) in patients with Alzheimer's disease and healthy controls: A multicentre phase 2 diagnostic study (2011) Lancet Neurol, 10, pp. 424-435. , 21481640 10.1016/S1474-4422(11)70077-1 1:CAS:528:DC%2BC3MXlt1Sls7c%3D
Cselényi, Z., Jönhagen, M.E., Forsberg, A., Halldin, C., Julin, P., Schou, M., Clinical validation of 18F-AZD4694, an amyloid-ß-specific PET radioligand (2012) J Nucl Med, 53, pp. 415-424. , 22323782 10.2967/jnumed.111.094029
Clark, C.M., Pontecorvo, M.J., Beach, T.G., Bedell, B.J., Coleman, R.E., Doraiswamy, P.M., Cerebral PET with florbetapir compared with neuropathology at autopsy for detection of neuritic amyloid-ß plaques: A prospective cohort study (2012) Lancet Neurol, 11, pp. 669-678. , 22749065 10.1016/S1474-4422(12)70142-4 1:CAS:528:DC%2BC38XhtV2gtb3E
Rinne, J.O., Wong, D.F., Wolk, D.A., Leinonen, V., Arnold, S.E., Buckley, C., [18F]Flutemetamol PET imaging and cortical biopsy histopathology for fibrillar amyloid ß detection in living subjects with normal pressure hydrocephalus: Pooled analysis of four studies (2012) Acta Neuropathol, 124, pp. 833-845. , 23053137 10.1007/s00401-012-1051-z 1:CAS:528:DC%2BC38XhslKls7zI
Okello, A., Koivunen, J., Edison, P., Archer, H.A., Turkheimer, F.E., Någren, K., Conversion of amyloid positive and negative MCI to AD over 3 years: An 11C-PIB PET study (2009) Neurology, 73, pp. 754-760. , 19587325 10.1212/WNL.0b013e3181b23564 1:CAS:528:DC%2BD1MXhtVKrsbvF
Koivunen, J., Scheinin, N., Virta, J.R., Aalto, S., Vahlberg, T., Någren, K., Amyloid PET imaging in patients with mild cognitive impairment: A 2-year follow-up study (2011) Neurology, 76, pp. 1085-1090. , 21325653 10.1212/WNL.0b013e318212015e 1:STN:280:DC%2BC3M3ot1Klsg%3D%3D
Morris, J.C., Price, J.L., Pathologic correlates of nondemented aging, mild cognitive impairment, and early-stage Alzheimer's disease (2001) J Mol Neurosci, 17, pp. 101-118. , 11816784 10.1385/JMN:17:2:101 1:CAS:528:DC%2BD3MXosVKitrg%3D
Varrone, A., Asenbaum, S., Vander Borght, T., Booij, J., Nobili, F., Någren, K., EANM procedure guidelines for PET brain imaging using [18F]FDG, version 2 (2009) Eur J Nucl Med Mol Imaging, 36, pp. 2103-2110. , 19838705 10.1007/s00259-009-1264-0
Kapucu, O.L., Nobili, F., Varrone, A., Booij, J., Vander Borght, T., Någren, K., EANM procedure guideline for brain perfusion SPECT using 99mTc-labelled radiopharmaceuticals, version 2 (2009) Eur J Nucl Med Mol Imaging, 36, pp. 2093-2102. , 19838703 10.1007/s00259-009-1266-y 1:CAS:528:DC%2BD1MXhsVCisb3L
Van Laere, K., Varrone, A., Booij, J., Vander Borght, T., Nobili, F., Kapucu, O.L., EANM procedure guidelines for brain neurotransmission SPECT/PET using dopamine D2 receptor ligands, version 2 (2010) Eur J Nucl Med Mol Imaging, 37, pp. 434-442. , 19838704 10.1007/s00259-009-1265-z 1:CAS:528:DC%2BC3cXhsVyisL0%3D
Darcourt, J., Booij, J., Tatsch, K., Varrone, A., Vander Borght, T., Kapucu, O.L., EANM procedure guidelines for brain neurotransmission SPECT using 123I-labelled dopamine transporter ligands, version 2 (2010) Eur J Nucl Med Mol Imaging, 37, pp. 443-450. , 19838702 10.1007/s00259-009-1267-x 1:CAS:528:DC%2BC3cXhsVyitr0%3D
Patel, M.R., Spertus, J.A., Brindis, R.G., Hendel, R.C., Douglas, P.S., Peterson, E.D., ACCF proposed method for evaluating the appropriateness of cardiovascular imaging (2005) J Am Coll Cardiol, 46, pp. 1606-1613. , 16226195 10.1016/j.jacc.2005.08.030
Delbeke, D., Chiti, A., Christian, P., Darcourt, J., Donohoe, K., Flotats, A., SNMMI/EANM guideline for guideline development 6.0 (2012) J Nucl Med Technol, 40, pp. 283-289. , 22743147 10.2967/jnmt.112.108787
Dubois, B., Feldman, H.H., Jacova, C., Cummings, J.L., Dekosky, S.T., Barberger-Gateau, P., Revising the definition of Alzheimer's disease: A new lexicon (2010) Lancet Neurol, 9, pp. 1118-1127. , 20934914 10.1016/S1474-4422(10)70223-4
Advisory Committee Briefing Document. New Drug Application 202-008: Amyvid (Florbetapir F 18 Injection), , http://www.fda.gov/downloads/AdvisoryCommittees/ CommitteesMeetingMaterials/Drugs/ PeripheralandCentralNervousSystemDrugsAdvisoryCommittee/UCM240265.pdf, Food and Drug Administration
Fleisher, A.S., Chen, K., Quiroz, Y.T., Jakimovich, L.J., Gomez, M.G., Langois, C.M., Florbetapir PET analysis of amyloid-ß deposition in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: A cross-sectional study (2012) Lancet Neurol, 11, pp. 1057-1065. , 23137949 10.1016/S1474-4422(12)70227-2 1:CAS:528:DC%2BC38Xhs12gt7%2FO
Villemagne, V.L., Pike, K.E., Chételat, G., Ellis, K.A., Mulligan, R.S., Bourgeat, P., Longitudinal assessment of Aß and cognition in aging and Alzheimer disease (2011) Ann Neurol, 69, pp. 181-192. , 21280088 10.1002/ana.22248 1:CAS:528:DC%2BC3MXisVCisLs%3D
Ossenkoppele, R., Prins, N.D., Pijnenburg, Y.A., Lemstra, A.W., Van Der Flier, W.M., Adriaanse, S.F., Impact of molecular imaging on the diagnostic process in a memory clinic (2012) Alzheimers Dement, , 10.1016/j.jalz.2012.07.003 23164552
Grundman, M., Pontecorvo, M.J., Salloway, S.P., Doraiswamy, P.M., Fleisher, A.S., Sadowsky, C.H., Potential impact of amyloid imaging on diagnosis and intended management in patients with progressive cognitive decline (2013) Alzheimer Dis Assoc Disord, 27, pp. 4-15. , 23203162 10.1097/WAD.0b013e318279d02a 1:CAS:528:DC%2BC3sXis12rsLk%3D
Chételat, G., Alzheimer disease: Aß-independent processes-rethinking preclinical AD (2013) Nat Rev Neurol, , 10.1038/nrneurol.2013.21
Johnson, K. A., Minoshima, S., Bohnen, N. I., Donohoe, K. J., Foster, N. L., Herscovitch, P., Appropriate use criteria for amyloid PET: A report of the Amyloid Imaging Task Force, the Society of Nuclear Medicine and Molecular Imaging, and the Alzheimer's Association (2013) J Nucl Med, 54, pp. 476-490. , 23359661 10. 2967/jnumed. 113. 120618 1: CAS: 528: DC%2BC3sXltV2ks7g%3
Klunk, W. E., Engler, H., Nordberg, A., Wang, Y., Blomqvist, G., Holt, D. P., Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B (2004) Ann Neurol, 55, pp. 306-319. , 14991808 10. 1002/ana. 20009 1: CAS: 528: DC%2BD2cXisFKntb8%3D
Kemppainen, N. M., Aalto, S., Wilson, I. A., N gren, K., Helin, S., Br ck, A., Voxel-based analysis of PET amyloid ligand [11C] PIB uptake in Alzheimer disease (2006) Neurology, 67, pp. 1575-1580. , 16971697 10. 1212/01. wnl. 0000240117. 55680. 0a 1: STN: 280: DC%2BD28nmslagsQ%3D%3D
Gomperts, S. N., Rentz, D. M., Moran, E., Becker, J. A., Locascio, J. J., Klunk, W. E., Imaging amyloid deposition in Lewy body diseases (2008) Neurology, 71, pp. 903-910. , 18794492 10. 1212/01. wnl. 0000326146. 60732. d6 1: STN: 280: DC%2BD1cngs1amtw%3D%3D
Ch telat, G., Villemagne, V. L., Bourgeat, P., Pike, K. E., Jones, G., Ames, D., Relationship between atrophy and beta-amyloid deposition in Alzheimer disease (2010) Ann Neurol, 67, pp. 317-324. , 20373343
Santillo, A. F., Gambini, J. P., Lannfelt, L., L ngstr m, B., Ulla-Marja, L., Kilander, L., In vivo imaging of astrocytosis in Alzheimer's disease: An 11C-L-deuteriodeprenyl and PIB PET study (2011) Eur J Nucl Med Mol Imaging, 38, pp. 2202-2208. , 21853308 10. 1007/s00259-011-1895-9
Bacskai, B. J., Frosch, M. P., Freeman, S. H., Raymond, S. B., Augustinack, J. C., Johnson, K. A., Molecular imaging with Pittsburgh Compound B confirmed at autopsy: A case report (2007) Arch Neurol, 64, pp. 431-434. , 17353389 10. 1001/archneur. 64. 3. 431
Ikonomovic, M. D., Klunk, W. E., Abrahamson, E. E., Mathis, C. A., Price, J. C., Tsopelas, N. D., Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease (2008) Brain, 131, pp. 1630-1645. , 18339640 10. 1093/brain/awn016
Ikonomovic, M. D., Abrahamson, E. E., Price, J. C., Hamilton, R. L., Mathis, C. A., Paljug, W. R., Early AD pathology in a [C-11] PiB-negative case: A PiB-amyloid imaging, biochemical, and immunohistochemical study (2012) Acta Neuropathol., 123, pp. 433-447. , 22271153 10. 1007/s00401-012-0943-2 1: CAS: 528: DC%2BC38Xisl2ktbk%3D
Rowe, C. C., Ackerman, U., Browne, W., Mulligan, R., Pike, K. L., O'Keefe, G., Imaging of amyloid in Alzheimer's disease with 18F-BAY94-9172, a novel PET tracer: Proof of mechanism (2008) Lancet Neurol, 7, pp. 129-135. , 18191617 10. 1016/S1474-4422 (08) 70001-2 1: CAS: 528: DC%2BD1cXis1WmsLw%3D
Wong, D. F., Rosenberg, P. B., Zhou, Y., Kumar, A., Raymont, V., Ravert, H. T., In vivo imaging of amyloid deposition in Alzheimer disease using the radioligand 18F-AV-45 (florbetapir F 18) (2010) J Nucl Med, 51, pp. 913-920. , 20501908 10. 2967/jnumed. 109. 069088 1: CAS: 528: DC%2BC3cXosl2ksb4%3D
Clark, C. M., Schneider, J. A., Bedell, B. J., Beach, T. G., Bilker, W. B., Mintun, M. A., Use of florbetapir-PET for imaging beta-amyloid pathology (2011) JAMA, 305, pp. 275-283. , 21245183 10. 1001/jama. 2010. 2008 1: CAS: 528: DC%2BC3MXhtVGrurw%3D
Csel nyi, Z., J nhagen, M. E., Forsberg, A., Halldin, C., Julin, P., Schou, M., Clinical validation of 18F-AZD4694, an amyloid- -specific PET radioligand (2012) J Nucl Med, 53, pp. 415-424. , 22323782 10. 2967/jnumed. 111. 094029
Clark, C. M., Pontecorvo, M. J., Beach, T. G., Bedell, B. J., Coleman, R. E., Doraiswamy, P. M., Cerebral PET with florbetapir compared with neuropathology at autopsy for detection of neuritic amyloid- plaques: A prospective cohort study (2012) Lancet Neurol, 11, pp. 669-678. , 22749065 10. 1016/S1474-4422 (12) 70142-4 1: CAS: 528: DC%2BC38XhtV2gtb3E
Rinne, J. O., Wong, D. F., Wolk, D. A., Leinonen, V., Arnold, S. E., Buckley, C., [18F] Flutemetamol PET imaging and cortical biopsy histopathology for fibrillar amyloid detection in living subjects with normal pressure hydrocephalus: Pooled analysis of four studies (2012) Acta Neuropathol, 124, pp. 833-845. , 23053137 10. 1007/s00401-012-1051-z 1: CAS: 528: DC%2BC38XhslKls7zI
Morris, J. C., Price, J. L., Pathologic correlates of nondemented aging, mild cognitive impairment, and early-stage Alzheimer's disease (2001) J Mol Neurosci, 17, pp. 101-118. , 11816784 10. 1385/JMN: 17: 2: 101 1: CAS: 528: DC%2BD3MXosVKitrg%3D
Kapucu, O. L., Nobili, F., Varrone, A., Booij, J., Vander Borght, T., N gren, K., EANM procedure guideline for brain perfusion SPECT using 99mTc-labelled radiopharmaceuticals, version 2 (2009) Eur J Nucl Med Mol Imaging, 36, pp. 2093-2102. , 19838703 10. 1007/s00259-009-1266-y 1: CAS: 528: DC%2BD1MXhsVCisb3L
Patel, M. R., Spertus, J. A., Brindis, R. G., Hendel, R. C., Douglas, P. S., Peterson, E. D., ACCF proposed method for evaluating the appropriateness of cardiovascular imaging (2005) J Am Coll Cardiol, 46, pp. 1606-1613. , 16226195 10. 1016/j. jacc. 2005. 08. 030
Fleisher, A. S., Chen, K., Quiroz, Y. T., Jakimovich, L. J., Gomez, M. G., Langois, C. M., Florbetapir PET analysis of amyloid- deposition in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: A cross-sectional study (2012) Lancet Neurol, 11, pp. 1057-1065. , 23137949 10. 1016/S1474-4422 (12) 70227-2 1: CAS: 528: DC%2BC38Xhs12gt7%2FO
Villemagne, V. L., Pike, K. E., Ch telat, G., Ellis, K. A., Mulligan, R. S., Bourgeat, P., Longitudinal assessment of A and cognition in aging and Alzheimer disease (2011) Ann Neurol, 69, pp. 181-192. , 21280088 10. 1002/ana. 22248 1: CAS: 528: DC%2BC3MXisVCisLs%3D
Ch telat, G., Alzheimer disease: A -independent processes-rethinking preclinical AD (2013) Nat Rev Neurol, , 10. 1038/nrneurol. 2013. 21
Non disponibile.
Nessun risultato. |
Nessun risultato. |
Vai a fine pagina Versione per copia e incolla facile Esporta tutto in BibTeX Esporta tutto in EndNote
Sciacca MFM, Monaco I, La Rosa C, Milardi D
* The active role of Ca(2+) ions in Abeta-mediated membrane damage (57 visite)
Chem Commun (ISSN: 1364-548xelectronic, 1359-7345linking), 2018 Apr 5; 54(29): 3629-3631.
Impact Factor: 6.169
Dettagli Esporta in BibTeX Esporta in EndNote
Oliveri V, Zimbone S, Giuffrida ML, Bellia F, Tomasello MF, Vecchio G
* Porphyrin Cyclodextrin Conjugates Modulate Amyloid Beta Peptide Aggregation and Cytotoxicity (80 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2018; 24(24): 6349-6353.
Impact Factor: 5.476
Dettagli Esporta in BibTeX Esporta in EndNote
Caraci F, Nicoletti F, Copani A
* Metabotropic glutamate receptors: the potential for therapeutic applications in Alzheimer's disease (168 visite)
Curr Opin Pharmacol (ISSN: 1471-4892), 2017 Dec 23; 38: 1-7.
Impact Factor: 6.313
Dettagli Esporta in BibTeX Esporta in EndNote
Oliveri V, Bellia F, Vecchio G
* Cyclodextrin Nanoparticles Bearing 8-Hydroxyquinoline Ligands as Multifunctional Biomaterials (170 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2017; 23(18): 4442-4449.
Impact Factor: 5.16
Dettagli Esporta in BibTeX Esporta in EndNote
Nicastro MC, Spigolon D, Librizzi F, Moran O, Ortore MG, Bulone D, Biagio PLS, Carrotta R
* Amyloid β-peptide insertion in liposomes containing GM1-cholesterol domains (83 visite)
Biophys Chem (ISSN: 0301-4622, 0301-4622linking), 2016; 208: 9-16.
Impact Factor: 2.402
Dettagli Esporta in BibTeX Esporta in EndNote
Giuffrida ML, Tomasello MF, Pandini G, Caraci F, Battaglia G, Busceti C, Di Pietro P, Pappalardo G, Attanasio F, Chiechio S, Bagnoli S, Nacmias B, Sorbi S, Vigneri R, Rizzarelli E, Nicoletti F, Copani A
* Monomeric ss-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons (241 visite)
Front Cell Neurosci (ISSN: 1662-5102), 2015 Aug 7; 9(AUGUST): 297-297.
Impact Factor: 4.609
Dettagli Esporta in BibTeX Esporta in EndNote
Caraci F, Pappalardo G, Basile L, Giuffrida A, Copani A, Tosto R, Sinopoli A, Giuffrida ML, Pirrone E, Drago F, Pignatello R, Guccione S
* Neuroprotective effects of the monoamine oxidase inhibitor Tranylcypromine and its amide derivatives against Abeta(1-42)-induced toxicity (301 visite)
Eur J Pharmacol (ISSN: 0014-2999), 2015 Jul 7; 764: 256-263.
Impact Factor: 2.73
Dettagli Esporta in BibTeX Esporta in EndNote
Merlo S, Basile L, Giuffrida ML, Sortino MA, Guccione S, Copani A
* Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity (45 visite)
J Nat Prod (ISSN: 0163-3864), 2015; 78(11): 2704-2711.
Impact Factor: 3.662
Dettagli Esporta in BibTeX Esporta in EndNote
Altieri F, Di Stadio CS, Severino V, Sandomenico A, Minopoli G, Miselli G, Di Maro A, Ruvo M, Chambery A, Quagliariello V, Masullo M, Rippa E, Arcari P
* Anti-amyloidogenic property of human gastrokine (249 visite)
Biochimie (ISSN: 0300-9084, 1638-6183, 0300-9084linking), 2014 Nov; 106C: 91-100.
Impact Factor: 2.963
Dettagli Esporta in BibTeX Esporta in EndNote
Iommelli F, De Rosa V, Gargiulo S, Panico M, Monti M, Greco A, Gramanzini M, Ortosecco G, Fonti R, Brunetti A, Del Vecchio S
* Monitoring Reversal of MET-Mediated Resistance to EGFR Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer Using 3 '-Deoxy-3 '-[F-18]-Fluorothymidine Positron Emission Tomography (256 visite)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2014 Sep 15; 20(18): 4806-4815.
Impact Factor: 8.722
Dettagli Esporta in BibTeX Esporta in EndNote
Grasso GI, Arena G, Bellia F, Rizzarelli E, Vecchio G
* Copper(II)-chelating homocarnosine glycoconjugate as a new multifunctional compound (179 visite)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2014 Feb; 131: 56-63.
Impact Factor: 3.444
Dettagli Esporta in BibTeX Esporta in EndNote
Autiero I, Saviano M, Langella E
* In silico investigation and targeting of amyloid beta oligomers of different size (183 visite)
Mol Biosyst (ISSN: 1742-206x, 1742-2051electronic), 2013 Aug; 9(8): 2118-2124.
Impact Factor: 3.18
Dettagli Esporta in BibTeX Esporta in EndNote
Marotta V, Ramundo V, Camera L, Del Prete M, Fonti R, Esposito R, Palmieri G, Salvatore M, Vitale M, Colao A, Faggiano A
* Sorafenib in advanced iodine-refractory differentiated thyroid cancer: Efficacy, safety and exploratory analysis of role of serum thyroglobulin and FDG-PET (215 visite)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 2013 May; 78(5): 760-767.
Impact Factor: 3.353
Dettagli Esporta in BibTeX Esporta in EndNote
Attanasio F, Convertino M, Magno A, Caflisch A, Corazza A, Haridas H, Esposito G, Cataldo S, Pignataro B, Milardi D, Rizzarelli E
* Carnosine Inhibits Abeta(42) Aggregation By Perturbing The H-Bond Network In And Around The Central Hydrophobic Cluster (262 visite)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2013 Mar 18; 14(5): 583-592.
Impact Factor: 3.06
Dettagli Esporta in BibTeX Esporta in EndNote
Pandini G, Pace V, Copani A, Squatrito S, Milardi D, Vigneri R
* Insulin has multiple antiamyloidogenic effects on human neuronal cells (238 visite)
Endocrinology (ISSN: 0013-7227, 1945-7170), 2013 Jan; 154(1): 375-387.
Impact Factor: 4.644
Dettagli Esporta in BibTeX Esporta in EndNote
Pannuzzo M, Milardi D, Raudino A, Karttunen M, La Rosa C
* Analytical model and multiscale simulations of Aβ peptide aggregation in lipid membranes: Towards a unifying description of conformational transitions, oligomerization and membrane damage (248 visite)
Phys Chem Chem Phys (ISSN: 1463-9076, 1463-3907, 1463-9084electronic), 2013; 15(23): 8940-8951.
Impact Factor: 4.198
Dettagli Esporta in BibTeX Esporta in EndNote
Attanasio F, De Bona P, Cataldo S, Sciacca MFM, Milardi D, Pignataro B, Pappalardo G
* Copper(II) and zinc(II) dependent effects on A beta 42 aggregation: a CD, Th-T and SFM study (227 visite)
New J Chem (ISSN: 1144-0546), 2013; 37(4): 1206-1215.
Impact Factor: 3.159
Dettagli Esporta in BibTeX Esporta in EndNote
Autiero I, Langella E, Saviano M
* Insights Into The Mechanism Of Interaction Between Trehalose-Conjugated Beta-Sheet Breaker Peptides And Aβ(1-42) Fibrils By Molecular Dynamics Simulations (236 visite)
Molecular Biosystems (ISSN: 1742-206x, 1742-2206), 2013; 9(11): 2835-2841.
Impact Factor: 3.18
Dettagli Esporta in BibTeX Esporta in EndNote
Giuffrida ML, Tomasello F, Caraci F, Chiechio S, Nicoletti F, Copani A
* Beta-Amyloid monomer and insulin/IGF-1 signaling in Alzheimer's disease (206 visite)
Mol Neurobiol (ISSN: 0893-7648), 2012 Dec; 46(3): 605-613.
Impact Factor: 5.471
Dettagli Esporta in BibTeX Esporta in EndNote
Grasso G, Giuffrida ML, Rizzarelli E
* Metallostasis And Amyloid Beta-Degrading Enzymes (312 visite)
Metallomics (ISSN: 1756-5901, 1756-591x, 1756-591xelectronic), 2012 Sep; 4(9): 937-949.
Impact Factor: 4.099
Dettagli Esporta in BibTeX Esporta in EndNote
Calafiore M, Copani A, Deng W
* DNA polymerase-β mediates the neurogenic effect of β-amyloid protein in cultured subventricular zone neurospheres (269 visite)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2012 Mar; 90(3): 559-567.
Impact Factor: 2.974
Dettagli Esporta in BibTeX Esporta in EndNote
Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (303 visite)
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
Impact Factor: 3.677
Dettagli Esporta in BibTeX Esporta in EndNote
Damante CA, Ösz K, Nagy Z, Grasso G, Pappalardo G, Rizzarelli E, Sóvágó I
* Zn2+'s ability to alter the distribution of Cu2+ among the available binding sites of A beta(1-16)-polyethylenglycol-ylated peptide: Implications in Alzheimer's disease (183 visite)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2011 Jun 20; 50(12): 5342-5350.
Impact Factor: 4.601
Dettagli Esporta in BibTeX Esporta in EndNote
Corona C, Frazzini V, Silvestri E, Lattanzio R, La Sorda R, Piantelli M, Canzoniero LM, Ciavardelli D, Rizzarelli E, Sensi SL
* Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice (227 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2011 Mar 15; 6(3): e17971-e17971.
Impact Factor: 4.092
Dettagli Esporta in BibTeX Esporta in EndNote
Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (364 visite)
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
Impact Factor: 4.883
Dettagli Esporta in BibTeX Esporta in EndNote
Grasso G, Pietropaolo A, Spoto G, Pappalardo G, Tundo GR, Ciaccio C, Coletta M, Rizzarelli E
* Copper(I) and Copper(II) Inhibit A beta Peptides Proteolysis by Insulin-Degrading Enzyme Differently: Implications for Metallostasis Alteration in Alzheimer's Disease (238 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Feb 25; 17(9): 2752-2762.
Impact Factor: 5.925
Dettagli Esporta in BibTeX Esporta in EndNote
Storto G, Di Giorgio E, De Renzo A, Pizzuti LM, Cerciello G, Nardelli A, Capacchione D, Castaldi E, Ortosecco G, Pace L
* Assessment of metabolic activity by PET-CT with F-18-FDG in patients with T-cell lymphoma (108 visite)
Br J Haematol (ISSN: 0007-1048, 0007-1048linking, 1365-2141electronic), 2010 Oct; 151(2): 195-197.
Impact Factor: 4.942
Dettagli Esporta in BibTeX Esporta in EndNote
Józsa E, Osz K, Kállay C, de Bona P, Damante CA, Pappalardo G, Rizzarelli E, Sóvágó I
* Nickel(ii) and mixed metal complexes of amyloid-β N-terminus (208 visite)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2010 Sep 14; 39(30): 7046-7053.
Impact Factor: 3.647
Dettagli Esporta in BibTeX Esporta in EndNote
Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Pizzuti LM, Lettieri A, Salvatore M
* PET/CT in cancer research: From preclinical to clinical applications (342 visite)
Contrast Media Mol Imaging (ISSN: 1555-4309, 1555-4309linking), 2010 Jul; 5(4): 190-200.
Impact Factor: 4.02
Dettagli Esporta in BibTeX Esporta in EndNote
Storto G, De Renzo A, Pellegrino T, Perna F, De Falco T, Erra P, Nardelli A, Speranza A, Klain M, Rotoli B, Pace L
* Assessment of Metabolic Response to Radioimmunotherapy with (90)Y-Ibritumomab Tiuxetan in Patients with Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma (143 visite)
Radiology (ISSN: 0033-8419, 1527-1315, 0033-8419linking), 2010 Jan; 254(1): 245-252.
Impact Factor: 6.069
Dettagli Esporta in BibTeX Esporta in EndNote
Jozsa E, Hosz K, Kallay C, De Bona P, Damante CA, Pappalardo G, Rizzarelli E, Sovago I
* Nickel (ii) And Mixed Metal Complexes Of Amyloid-B N-Terminus. Results Of Potentiometric And Spectroscopic Studies On The Binary Nickel (ii) And Mixed Metal Nickel (ii)-Copper (ii) And Nickel (ii)-Copper (ii)-Zinc (ii) Complexes Of Peptide Fragments (204 visite)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2010; 39(30): 7046-7053.
Impact Factor: 3.647
Dettagli Esporta in BibTeX Esporta in EndNote
Giuffrida ML, Caraci F, De Bona P, Pappalardo G, Nicoletti F, Rizzarelli E, Copani A
* The monomer state of beta-amyloid: where the Alzheimer's disease protein meets physiology (202 visite)
Rev Neurosci (ISSN: 0334-1763), 2010; 21(2): 83-93.
Impact Factor: 2.047
Dettagli Esporta in BibTeX Esporta in EndNote
Damante CA, Osz K, Nagy Z, Pappalardo G, Grasso G, Impellizzeri G, Rizzarelli E, Sóvágó I
* Metal Loading Capacity Of Abeta N-Terminus: A Combined Potentiometric And Spectroscopic Study Of Zinc (ii) Complexes With Abeta (1-16), Its Short Or Mutated Peptide Fragments And Its Polyethylene Glycol-Ylated Analogue (203 visite)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2009 Nov 2; 48(21): 10405-10415.
Impact Factor: 4.657
Dettagli Esporta in BibTeX Esporta in EndNote
Giuffrida ML, Caraci F, Pignataro B, Cataldo S, De Bona P, Bruno V, Molinaro G, Pappalardo G, Messina A, Palmigiano A, Garozzo D, Nicoletti F, Rizzarelli E, Copani A
* Beta-Amyloid Monomers Are Neuroprotective (242 visite)
J Neurosci (ISSN: 1529-2401, 0270-6474), 2009 Sep 26; 29(34): 10582-10587.
Impact Factor: 3.669
Dettagli Esporta in BibTeX Esporta in EndNote
Zannetti A, Del Vecchio S, Iommelli F, Del Gatto A, De Luca S, Zaccaro L, Papaccioli A, Sommella J, Panico M, Speranza A, Grieco P, Novellino E, Saviano M, Pedone C, Salvatore M
* Imaging of alpha(v)beta(3) expression by a bifunctional chimeric RGD peptide not cross-reacting with alpha(v)beta(5) (228 visite)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2009 Sep 15; 15(16): 5224-5233.
Impact Factor: 6.747
Dettagli Esporta in BibTeX Esporta in EndNote
Zannetti A, Del Vecchio S, Iommelli F, Del Gatto A, De Luca S, Zaccaro L, Papaccioli A, Sommella J, Panico M, Speranza A, Grieco P, Novellino E, Saviano M, Pedone C, Salvatore M
* Imaging of αvβ3 expression by a bifunctional chimeric RGD peptide not cross-reacting with α vβ5 (260 visite)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2009 Sep 15; 15(16): 5224-5233.
Impact Factor: 6.747
Dettagli Esporta in BibTeX Esporta in EndNote
De Bona P, Giuffrida ML, Caraci F, Copani A, Pignataro B, Attanasio F, Cataldo S, Pappalardo G, Rizzarelli E
* Design And Synthesis Of New Trehalose-Conjugated Pentapeptides As Inhibitors Of Abeta (1-42) Fibrillogenesis And Toxicity (309 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 220-228.
Impact Factor: 1.807
Dettagli Esporta in BibTeX Esporta in EndNote
D'Auria G, Vacatello M, Falcigno L, Paduano L, Mangiapia G, Calvanese L, Gambaretto R, Dettin M, Paolillo L
* Self-assembling properties of ionic-complementary peptides (219 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 210-219.
Impact Factor: 1.807
Dettagli Esporta in BibTeX Esporta in EndNote
Ciaccio C, Tundo GR, Grasso G, Spoto G, Marasco D, Ruvo M, Gioia M, Rizzarelli E, Coletta M
* Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity (206 visite)
J Mol Biol (ISSN: 1089-8638, 0022-2836, 1089-8638electronic), 2009 Feb 6; 385(5): 1556-1567.
Impact Factor: 3.871
Dettagli Esporta in BibTeX Esporta in EndNote
Caraci F, Busceti C, Biagioni F, Aronica E, Mastroiacovo F, Cappuccio I, Battaglia G, Bruno V, Caricasole A, Copani A, Nicoletti
* The Wnt antagonist, Dickkopf-1, as a target for the treatment of neurodegenerative disorders (161 visite)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2008 Dec; 33(12): 2401-2406.
Impact Factor: 2.26
Dettagli Esporta in BibTeX Esporta in EndNote
Damante CA, Ösz K, Nagy Z, Pappalardo G, Grasso G, Impellizzeri G, Rizzarelli E, Sóvágó I
* The Metal Loading Ability Of Beta-Amyloid N-Terminus: A Combined Potentiometric And Spectroscopic Study Of Copper (ii) Complexes With Beta-Amyloid (1-16), Its Short Or Mutated Peptide Fragments, And Its Polyethylene Glycol (peg)-Ylated Analogue (173 visite)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2008 Oct 20; 47(20): 9669-9683.
Impact Factor: 4.147
Dettagli Esporta in BibTeX Esporta in EndNote
Caraci F, Battaglia G, Busceti C, Biagioni F, Mastroiacovo F, Bosco P, Drago F, Nicoletti F, Sortino MA, Copani A
* TGF-β1 protects against Aβ-neurotoxicity via the phosphatidylinositol-3-kinase pathway (140 visite)
Neurobiology Of Disease (ISSN: 0969-9961), 2008 May; 30(2): 234-242.
Impact Factor: 4.852
Dettagli Esporta in BibTeX Esporta in EndNote
Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA
* The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (160 visite)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
Impact Factor: 4.823
Dettagli Esporta in BibTeX Esporta in EndNote
Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
* The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (159 visite)
Bba-Mol Basis Dis (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
Impact Factor: 3.078
Dettagli Esporta in BibTeX Esporta in EndNote
Giuffrida ML, Grasso G, Ruvo M, Pedone C, Saporito A, Marasco D, Pignataro B, Cascio C, Copani A, Rizzarelli E
* Abeta(25-35) And Its C- And/Or N-Blocked Derivatives: Copper Driven Structural Features And Neurotoxicity (236 visite)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Feb 15; 85(3): 623-633.
Impact Factor: 3.268
Dettagli Esporta in BibTeX Esporta in EndNote
Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
* Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (163 visite)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2006; 26(43): 10949-10957.
Impact Factor: 2.117
Dettagli Esporta in BibTeX Esporta in EndNote
Calafiore M, Battaglia G, Zappal A, Trovato-Salinaro E, Caraci F, Caruso M, Vancheri C, Sortino MA, Nicoletti F, Copani A
* Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to β-amyloid (133 visite)
Neurobiol Aging (ISSN: 0197-4580, 1558-1497electronic), 2006; 27(4): 606-613.
Impact Factor: 5.599
Dettagli Esporta in BibTeX Esporta in EndNote
Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G
* Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (199 visite)
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
Impact Factor: 1.995
Dettagli Esporta in BibTeX Esporta in EndNote
Filippo C, Mariangela C, Giuseppina F, Pier Luigi C, Angelo B, Marco C, Giuseppe B, Paolo B, Ferdinando N, Agata C, Maria Angela S
* Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against β-amyloid toxicity (386 visite)
Brain Res (ISSN: 0006-8993), 2005; 1047(1): 30-37.
Impact Factor: 2.296
Dettagli Esporta in BibTeX Esporta in EndNote
Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F
* Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (235 visite)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2004 Jun 30; 24(26): 6021-6027.
Impact Factor: 2.384
Dettagli Esporta in BibTeX Esporta in EndNote
Wiesehan K, Buder K, Linke RP, Patt S, Stoldt M, Unger E, Schmitt B, Bucci E, Willbold D
* Selection of D-amino-acid peptides that bind to Alzheimer's disease amyloid peptide Aβ1-42 by mirror image phage display (232 visite)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003; 4(8): 748-753.
Impact Factor: 3.992
Dettagli Esporta in BibTeX Esporta in EndNote
Aime S, Dastrù W, Gobetto R, Viale A
An NMR study of H(μ-H)Os3(CO)11 (155 visite)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2000; 39(11): 2422-2425.
Impact Factor: 2.712
Dettagli Esporta in BibTeX Esporta in EndNote
52 Records (51 escludendo Abstract e Conferenze).
Impact factor totale: 209.346 (205.254 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 214.94 (210.403 escludendo Abstract e Conferenze).
Impact factor totale: 209.346 (205.254 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 214.94 (210.403 escludendo Abstract e Conferenze).
Esporta in BibTeX Esporta in EndNote
Ultima modifica di Marco Comerci in data Thursday 19 March 2015, 13:32:14
258 visite. Ultima visita in data Sunday 10 November 2019, 18:10:31
ibb.cnr.it