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[Cardiac tomography with 99mTc-tetrofosmin after nitrate administration in patients with ischemic cardiopathy and left ventricular dysfunction] (89 visite)

Menna F, Acampa W, Florimonte L, Ferro A, Borrelli G, Mainolfi C, Cuocolo A

Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2000 Apr; 99(4): 258-263.

Tipo di articolo: Journal Article,

Impact factor: 1.368

Impact factor a 5 anni: 1.47


Parole chiave: Adult, Aged, Chronic Disease, Heart, Drug Effects, Radionuclide Imaging, Hemodynamics, Humans, Middle Aged, Myocardial Ischemia, Physiopathology, Nitroglycerin, Diagnostic Use, Organophosphorus Compounds, Organotechnetium Compounds, Radiopharmaceuticals, Time Factors, Tomography, Emission-Computed, Single-Photon, Instrumentation, Methods, Statistics, Numerical Data, Vasodilator Agents, Ventricular Dysfunction,

Url: Non disponibile.

PURPOSE: To investigate the role of technetium-99m (99mTc) tetrofosmin single-photon emission Computed Tomography (SPECT) associated with nitrate administration in the detection of hypoperfused but still viable myocardium in patients with chronic coronary artery disease and left ventricular (LV) dysfunction. MATERIAL AND METHODS: Twenty-two patients (mean age 54 +/- 11 years) with coronary artery disease, previous myocardial infarction and LV dysfunction (LV ejection fraction 38 +/- 13%) were examined. On different days all patients underwent 99mTc tetrofosmin (740 MBq) SPECT under control conditions at rest and after sublingual nitroglycerin administration (10 mg). Regional tetrofosmin activity was quantitatively measured in 22 myocardial segments per patient. In each segment, tracer uptake was expressed as a percentage of the region with the peak activity. RESULTS: Under control conditions, 267 myocardial segments (55%) showed normal tetrofosmin uptake (> 70% of peak activity), 107 segments (22%) showed a moderate reduction (51-70%) and 110 segments (23%) a severe reduction (< or = 50%) in tracer uptake. Among the 110 segments with a severe reduction in tetrofosmin uptake, 20 (18%) showed increased tracer uptake > or = 10% of after nitrate administration (from 44 +/- 5% to 58 +/- 3%, p < 0.0001). The remaining 90 (82%) segments with a severe reduction in tetrofosmin uptake did not show any change after nitroglycerin administration (from 38 +/- 9% to 39 +/- 8%, p = ns). CONCLUSIONS: In patients with chronic coronary artery disease and LV dysfunction, tetrofosmin cardiac SPECT associated with sublingual nitrate administration allows the detection of severely hypoperfused but still viable myocardium.
Dipartimento di Scienze Biomorfologiche e Funzionali, Universita Federico II, Napoli.,
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Evaluation of cerebral hemodynamics with microbubble enhanced ultrasound imaging and magnetic resonance imaging in MS patients (71 visite) (PDF 72 visite)
Mancini M
6th Annual Meeting Of The International Society For Neurovascular Disease, 2016 Apr; N/D: N/D-N/D.
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* Long-term clinical results and MRI changes after autologous chondrocyte implantation in the knee of young and active middle aged patients (164 visite)
Rosa D, Balato G, Ciaramella G, Soscia E, Improta G, Triassi M
J Orthop Traumatol (ISSN: 1590-9999electronic, 1590-9921linking), 2015 Oct 24; 17(1): 55-62.
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* Cardiac Radionuclide Imaging After Coronary Artery Revascularization (60 visite)
Petretta M, Cuocolo R, Acampa W, Cuocolo A
Curr Cardiovasc Imaging Rep (ISSN: 1941-9066), 2014; 7(3): 1-9.
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* Italian multicenter study on venous hemodynamics in multiple sclerosis: Advanced Sonological Protocol (91 visite)
Malferrari G, Del Sette M, Zedde M, Sanguigni S, Carraro C, Baracchini C, Mancini M, Stolz E
Perspect Med (ISSN: 2211-968x), 2012; 1-12: 399-403.
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* EANM/ESC guidelines for radionuclide imaging of cardiac function (185 visite)
Hesse B, Lindhardt TB, Acampa W, Anagnostopoulos C, Ballinger J, Bax JJ, Edenbrandt L, Flotats A, Germano G, Stopar TG, Franken P, Kelion A, Kjaer A, Le Guludec D, Ljungberg M, Maenhout AF, Marcassa C, Marving J, Mckiddie F, Schaefer WM, Stegger L, Underw
Eur J Nucl Med Mol Imaging (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Apr; 35(4): 851-885.
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* Triphasic helical CT in Budd-Chiari syndrome: Patterns of enhancement in acute, subacute and chronic disease (109 visite)
Camera L, Mainenti PP, Di Giacomo A, Romano M, Rispo A, Alfinito F, Imbriaco M, Soscia E, Salvatore M
Clin Radiol (ISSN: 0009-9260), 2006 Apr; 61(4): 331-337.
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* Radionuclide Imaging in Patients with Ischemic Heart Failure (66 visite)
Acampa W, Petretta M, Evangelista L, Petretta A, Cuocolo A
Current Medical Imaging Reviews (ISSN: 1573-4056), 2005 Jan; 1(1): N/D-N/D.
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* Radionuclide Imaging In Patients With Ischemic Heart Disease (64 visite)
Acampa W, Petretta M, Evangelista L, Petretta A, Cuocolo A
Current Medical Research And Opinion, 2005; 1: 17-23.
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* Preliminary Tests of a Prototype System for Optical and Radionuclide Imaging in Small Animals (78 visite)
Celentano L, Laccetti P, Liuzzi R, Mettivier G, Montesi MC, Autiero M, Riccio P, Roberti G, Russo P, Salvatore M
Ieee Transactions On Nuclear Science (ISSN: 0018-9499), 2003 Oct; 50(5II): 1693-1701.
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* Preliminary tests of a prototype system for optical and radionuclide imaging in small animals (95 visite)
Celentano L, Laccetti P, Liuzzi R, Mettivier G, Montesi MC, Autiero M, Riccio P, Roberti G, Russo P, Salvatore M
Ieee Nuclear Science Symposium And Medical Imaging Conference, 2002; 3: 1746-1750.
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* Myocardial viability assessment in regions of left ventricular dysfunction. Part I: Radionuclide imaging and clinical implications (72 visite)
Petretta M, Acampa W, Cuocolo A
Nuclear Medicine Communications (ISSN: 0143-3636, 1473-5628), 2001 Jun; 22(6): 607-611.
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* The diagnostic role of radionuclide imaging in evaluation of patients with nonhypersecreting adrenal masses (77 visite) (PDF 110 visite)
Maurea S, Klain M, Mainolfi C, Ziviello M, Salvatore M
Journal Of Nuclear Medicine (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2001 Jun; 42(6): 884-892.
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Noninvasive evaluation of cardiac hemodynamics during exercise in patients with chronic heart failure: Effects of short-term Coenzyme Q10 treatment (78 visite)
Morisco C, Nappi A, Argenziano L, Sarno D, Fonatana D, Imbriaco M, Nicolai E,  Romano M, Rosiello G, Cuocolo A
Molecular Aspects Of Medicine (ISSN: 0098-2997, 1872-9452), 1994; 15(SUPPL.1): s155-s155.
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Regional Hemodynamics During Ketanserin Treatment In Hypertensive Patients (64 visite)
Ferrara LA, Mancini M, Soricelli A, Postiglione A, Iannuzzi A, Iannuzzi R
Fifth European Meeting On Hypertension European Society Of Hypertension Milan, 1991 Oct; N/D: 209-209.
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14 Records (9 escludendo Abstract e Conferenze).
Impact factor totale: 19.613 (16.554 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 30.074 (18.673 escludendo Abstract e Conferenze).

Interrogazione bibliografica effettuata: (([btitle] "Chronic Disease" OR [btitle] "Drug Effects" OR [btitle] "Radionuclide Imaging" OR [btitle] "Hemodynamics" OR [btitle] "Middle Aged") AND NOT [id] = 9966)







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