In vivo detection of malignant thymic masses by indium-111-DTPA-D- Phe1-octreotide scintigraphy(113 visite) Lastoria S, Vergara E, Palmieri G, Acampa W, Varrella P, Caracò C, Bianco RA, Muto P, Salvatore M
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Greaves, M. F., Target cells, differentiation and clonal evolution in chronic granulocytic leukemia: A model for understanding the biology of malignancy (1982) Chronic Granulocytic Leukemia, pp. 15-47. , Shaw MT, ed. New York: Praeger
Pierce, G. B., Nakane, P. K., Martinez-Hernandez, A., Ward, J. M., Ultrastructural comparison of differentiation of stem cells of murine adenocarcinomas of colon and breast with their normal counterparts (1977) J Natl Cancer Inst, 58, pp. 1329-1345
Larsson, L. I., Regulatory peptides and amines during ontogeny and in nonendocrine cancers: Occurrence and possible functional significance (1988) Prog Histochem Cytochem, 17, pp. 89-111
Reubi, J. C., Waser, B., Horisberger, U., In vitro autoradiographic and in vivo scintigraphic localization of somatostatin receptors in human lymphatic tissue (1993) Blood, 82, pp. 2143-2151
Lamberts, S. W. J., Krenning, E. P., Reubi, J. C., The role of somatostatin and its analogues in the diagnosis and treatment of tumors (1991) Endocrinol Rev, 12, pp. 450-482
Reubi, J. C., Laissue, J., Krenning, E. P., Lamberts, S. W. J., Somatostatin receptors in human cancer: Incidence, characteristics, functional correlates and clinical implications (1992) J Steroid Biochem Mol Biol, 43, pp. 27-35
Krenning, E. P., Kwekkeboom, D. J., Bakker, W. H., Somatostatin receptor scintigraphy with [111In-DTPA-D-Phe1] - and [l23I-Tyr3] -octreotide: The Rotterdam experience with over 1000 patients (1993) Eur J Nucl Med, 20, pp. 716-731
Krenning, E. P., Bakker, W. H., Breeman, W. A. P., Localization of endocrine-related tumors with radioiodinated analogue of somatostatin (1989) Lancet, 1, pp. 242-244
Kwekkeboom, D. J., Kho, G. S., Lamberts, S. W. J., The value of octreotide scintigraphy in patients with lung cancer (1994) Eur J Nucl Med, 21, pp. 1106-1113
Vanhagen, P. M., Krenning, E. P., Reubi, J. C., Somatostatin analogue scintigraphy of malignant lymphoma (1993) Br J Haematol, 83, pp. 75-79
Van Eijck, C. H., Krenning, E. P., Bootsma, A., Somatostatin receptor scintigraphy in primary breast cancer (1994) Lancet, 343, pp. 640-643
Lee, J. D., Kim, D. I., Lee, J. T., Chang, J. W., Park, C. Y., Indium-111-pentetreotide imaging in intra-axial brain tumors: Comparison with thallium-201 SPECT and MRI (1995) J Nucl Med, 36, pp. 537-541
Reubi, J. C., Landolt, A. M., The growth hormone responses to octreotide in acromegaly correlate with adenoma somatostatin receptor status (1991) J Clin Endocrinol Metab, 68, pp. 844-850
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Moina, P. L., Siergel, M. J., Glazer, H. S., Thymic mass on MR imaging (1990) Am J Roentgenol, 155, pp. 495-500
Lin, R. S., Yen, S. H., Huang, M. H., Use of fluorine-18 fluorodeoxyglucose positron emission tomography in the detection of thymoma: A preliminary report (1995) Eur J Nucl Med, 22, pp. 1402-1407
Pearse, A. G. E., The cytochemistry and ultrastructure of polypeptide hormone producing cells of the APUD series and the embryologic, physiologic and pathologic implication of the concept (1969) J Histochem Cytochem, 17, pp. 303-312
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Many tumors with neuroendocrine characteristics express high amounts of somatostatin receptors that enable in vivo imaging with [111In-DTPA-D- Phe1]-octreotide. In this study, we have analyzed the feasibility in detecting and characterizing thymic masses by somatostatin receptor scintigraphy (SRS). Methods: Eighteen patients (13 women, 5 men, ages 18-78 yr; mean ± s.d. = 42.1 ± 17.6 yr) were enrolled in this study. Eleven patients were studied during diagnosis and seven during routine follow-up. In seven patients, myasthenia gravis was the presenting symptom. SRS was performed within 4 wk after CT and/or MRI. Planar and tomographic images were acquired within 24 hr after the injection of approximately 111 MBq of [111In-DTPA-D-Phe1]-octreotide. The scintigraphic results were categorized according to the histologic findings. Results: Histology diagnosed 10 mixed epithelial/lymphoid thymomas (8 with prevalent epithelial component), 2 thymic carcinomas, 1 thymic carcinoid, 1 lymphangioma and 4 thymic hyperplasias. Two thymoma were Stage I, 3 were Stage II, 2 were Stage III and 5 were Stage IV, as was the thymic carcinoid. Indium-111-DTPA-D- Phe1-octreotide concentrated in primary and/or metastatic sites of thymic tumors, thereby enabling successful external gamma imaging of sites greater than 1.5 cm in size. Tumor-to-lung (T/L) ratios were as high as 7.6-fold (range 1.7-7.6). Untreated thymomas showed higher T/L (4.34 ± 1.57) than treated ones (2.68 ± 1.18). No uptake was detectable in the four patients with benign thymic hyperplasia and the patient with the lymphangioma. Conclusion: Indium-111-DTPA-D-Phe1-octreotide is avidly concentrated within thymic tumors, but it is not concentrated by thymic hyperplasia, which allows differential diagnosis. Thus, in patients with myasthenia gravis, SRS may have a role in characterizing thymic masses, thereby overcoming the limits of cross-sectional imaging modalities.
Aloj L, Aurilio M, Rinaldi V, D'Ambrosio L, Tesauro D, Peitl PK, Maina T, Mansi R, Von Guggenberg E, Joosten L, Sosabowski JK, Breeman WA, De Blois E, Koelewijn S, Melis M, Waser B, Beetschen K, Reubi JC, De Jong M * The EEE project(130 visite) Proc Int Cosm Ray Conf Icrc Universidad Nacional Autonoma De Mexico, 2007; 5(HEPART2): 977-980. Impact Factor:0 DettagliEsporta in BibTeXEsporta in EndNote
335 Records (321 escludendo Abstract e Conferenze). Impact factor totale: 1009.222 (965.345 escludendo Abstract e Conferenze). Impact factor a 5 anni totale: 1154.997 (1098.372 escludendo Abstract e Conferenze).
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