MRI Tracking of Macrophages Labeled with Glucan Particles Entrapping perfluorocarbons based nanoparticles
Contact person: Valeria Menchise, valeria.menchise
unito.it
Actors: Valeria Menchise, valeria.menchiseunito.it,
Research areas: Preclinical Imaging,
Contact person: Valeria Menchise, valeria.menchise
unito.itActors: Valeria Menchise, valeria.menchise
unito.it, Description:
The most used class of MRI probes for cellular imaging is represented by iron oxide nanoparticles (IONPs). Even if they succeeded at both preclinical and clinical levels in many cases, the negative constrast they produce as T2 or T2* contrast agents may be a drawback, making an unambiguous detection of the labelled cells very challenging especially in organs with an intrinsically low MRI signal (e.g. lung, bones) or in the presence of haemorrhages. In addition, the contrast generated by IONP-labelled cells is linearly correlated to the cells number only at low iron concentrations.
A new emerging approach for cellular MRI is based on agents containing fluorine ( 19 F, 100% natural abundance). 19 F-based MRI has gained huge attention in the last 20 years, owing to the possibility to obtain quantitative information in a diagnostic MR protocol because of the absence of background signal allows specific and selective detection of the administrated 19 F-containing probes in vivo. Moreover, the chemical shift of 19 F is spread out over a wide range, thus allowing the selective observation of different agents present in the same anatomical district. The 19 F-containing contrast agents studied so far are mostly nanosized.
Because of their high payload of 19 F atoms, perfluorocarbons (PFCs), under the form of nanoemulsions, are the most frequently used 19 F-MRI contrast agents for biological applications. Recent studies have demonstrated the potential of PFCs to label and image cells (mostly phagocytic) either in vitro or in vivo and have demonstratedthe the potential of cellular 19 F-MRI, especially for quantifying the number of labelled cells.
This research project is focused on the development of a labelling procedure based on Glucan Particles (GPs), a high potential biocompatible microcarriers in the molecular imaging field, loaded with perfluoro-crown-ether. Our data showed that the use of loaded GPs improved substantially the labelling efficiency of macrophages in 19 F-MRI cellular imaging experiments in vitro. Further studies are in due course with the main goal to demonstrate the performance of PFCs-loaded GPs for the visualization and the tracking of the macrophage recruitment in an animal model.
The most used class of MRI probes for cellular imaging is represented by iron oxide nanoparticles (IONPs). Even if they succeeded at both preclinical and clinical levels in many cases, the negative constrast they produce as T2 or T2* contrast agents may be a drawback, making an unambiguous detection of the labelled cells very challenging especially in organs with an intrinsically low MRI signal (e.g. lung, bones) or in the presence of haemorrhages. In addition, the contrast generated by IONP-labelled cells is linearly correlated to the cells number only at low iron concentrations.
A new emerging approach for cellular MRI is based on agents containing fluorine ( 19 F, 100% natural abundance). 19 F-based MRI has gained huge attention in the last 20 years, owing to the possibility to obtain quantitative information in a diagnostic MR protocol because of the absence of background signal allows specific and selective detection of the administrated 19 F-containing probes in vivo. Moreover, the chemical shift of 19 F is spread out over a wide range, thus allowing the selective observation of different agents present in the same anatomical district. The 19 F-containing contrast agents studied so far are mostly nanosized.
Because of their high payload of 19 F atoms, perfluorocarbons (PFCs), under the form of nanoemulsions, are the most frequently used 19 F-MRI contrast agents for biological applications. Recent studies have demonstrated the potential of PFCs to label and image cells (mostly phagocytic) either in vitro or in vivo and have demonstratedthe the potential of cellular 19 F-MRI, especially for quantifying the number of labelled cells.
This research project is focused on the development of a labelling procedure based on Glucan Particles (GPs), a high potential biocompatible microcarriers in the molecular imaging field, loaded with perfluoro-crown-ether. Our data showed that the use of loaded GPs improved substantially the labelling efficiency of macrophages in 19 F-MRI cellular imaging experiments in vitro. Further studies are in due course with the main goal to demonstrate the performance of PFCs-loaded GPs for the visualization and the tracking of the macrophage recruitment in an animal model.
Figures:
Selected papers:
Menchise, V., Digilio, G., Gianolio, E., Catanzaro, V., Carrera, C., Aime, S. In Vivo Labeling of B16 Melanoma Tumor Xenograft with a Thiol-Reactive Gadolinium Based MRI Contrast Agent Molecular Pharmaceutics (2011) 1750-1756 DOI: 10.1021/mp2001044.
Catanzaro, C., Gringeri, C. V., Menchise, V., Padovan, S., Boffa, C., Dastrù, W., Chaabane, L., Digilio, G., Aime, S. A R2p/R1p ratiometric procedure to assess Matrix Metalloproteinase-2 activity by Magnetic Resonance Imaging. Angew. Chem. Int. (2013), 52, 3926–3930. (DOI: 10.1002/anie.201209286).
Figueiredo, S., Cutrin, J.C., Rizzitelli, S., De Luca, E., Moreira, J.N., Geraldes, C.F., Aime, S., Terreno, E. MRI tracking of macrophages labeled with glucan particles entrapping a water insoluble paramagnetic Gd-based agent. Mol Imaging Biol. 2013;15:307-15.
Rizzitelli, S., Giustetto, P., Cutrin, J.C., Delli Castelli, D., Boffa, C., Ruzza, M., Menchise, V., Molinari, F., Aime, S., Terreno, E. Sonosensitive theranostic liposomes for preclinical in vivo MRI-guided visualization of doxorubicin release stimulated by pulsed low intensity non-focused ultrasound J Control Release 2015 Jan; 202C: 21-30 | PMID: 25626083.
Chirizzi C., Menchise, V., Delli Castelli, D., Dastrù, W., Aime. S. and Terreno, E. Glucan Particles Loaded with Fluorinated Emulsions: a Sensitivity Improvement for the Visualization of Phagocytic Cells by 19F-MRI 2015 submitted to Current Molecular Imaging.
Menchise, V., Digilio, G., Gianolio, E., Catanzaro, V., Carrera, C., Aime, S. In Vivo Labeling of B16 Melanoma Tumor Xenograft with a Thiol-Reactive Gadolinium Based MRI Contrast Agent Molecular Pharmaceutics (2011) 1750-1756 DOI: 10.1021/mp2001044.
Catanzaro, C., Gringeri, C. V., Menchise, V., Padovan, S., Boffa, C., Dastrù, W., Chaabane, L., Digilio, G., Aime, S. A R2p/R1p ratiometric procedure to assess Matrix Metalloproteinase-2 activity by Magnetic Resonance Imaging. Angew. Chem. Int. (2013), 52, 3926–3930. (DOI: 10.1002/anie.201209286).
Figueiredo, S., Cutrin, J.C., Rizzitelli, S., De Luca, E., Moreira, J.N., Geraldes, C.F., Aime, S., Terreno, E. MRI tracking of macrophages labeled with glucan particles entrapping a water insoluble paramagnetic Gd-based agent. Mol Imaging Biol. 2013;15:307-15.
Rizzitelli, S., Giustetto, P., Cutrin, J.C., Delli Castelli, D., Boffa, C., Ruzza, M., Menchise, V., Molinari, F., Aime, S., Terreno, E. Sonosensitive theranostic liposomes for preclinical in vivo MRI-guided visualization of doxorubicin release stimulated by pulsed low intensity non-focused ultrasound J Control Release 2015 Jan; 202C: 21-30 | PMID: 25626083.
Chirizzi C., Menchise, V., Delli Castelli, D., Dastrù, W., Aime. S. and Terreno, E. Glucan Particles Loaded with Fluorinated Emulsions: a Sensitivity Improvement for the Visualization of Phagocytic Cells by 19F-MRI 2015 submitted to Current Molecular Imaging.
MRI Tracking of Macrophages Labeled with Glucan Particles Entrapping perfluorocarbons based nanoparticles 
| ▼ Imaging Tumor Acidosis |
MRI Tracking of Macrophages Labeled with Glucan Particles Entrapping perfluorocarbons based nanoparticles
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Vaccaro M, Accardo A, D'Errico G, Schillen K, Radulescu A, Tesauro D, Morelli G, Paduano L
* Peptides and gd complexes containing colloidal assemblies as tumor-specific contrast agents in MRI: Physicochemical characterization (379 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2007 Sep; 93(5): 1736-1746.
Impact Factor: 4.627
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Tesauro D, Accardo A, Gianolio E, Paduano L, Teixeira J, Schillén K, Aime S, Morelli G
* Peptide derivatized lamellar aggregates as target-specific MRI contrast agents (556 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 25; 8(8): 950-955.
Impact Factor: 3.446
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Accardo A, Tesauro D, Morelli G, Gianolio E, Aime S, Vaccaro M, Mangiapia G, Paduano L, Schillén K
* High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI (391 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2007 Feb; 12(2): 267-276.
Impact Factor: 3.325
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Vaccaro M, Accardo A, Tesauro D, Mangiapia G, Loef D, Schillen K, Soederman O, Morelli G, Paduan L
* Supramolecular aggregates of amphiphilic gadolinium complexes as blood pool MRI/MRA contrast agents: Physicochemical characterization (381 views)
Langmuir (ISSN: 0743-7463), 2006 Jul 18; 22(15): 6635-6643.
Impact Factor: 3.902
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Cuocolo A, Acampa W, Imbriaco M, De Luca N, Iovino GL, Salvatore M
* The many ways to myocardial perfusion imaging (449 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2005 Mar; 49(1): 4-18.
Impact Factor: 1.724
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Morelli G, Accardo A, Tesauro D, Pedone C, Mangiapia G, Paduano L, Gianolio E
* Multicomponent aggregates containing the CCK8 bioactive peptide and Gd complexes as target-specific MRI contrast agents (235 views)
Peptides 2004 Proceedings, 2005; N/D: N/D-N/D.
Impact Factor: 0
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Accardo A, Tesauro D, Roscigno P, Gianolio E, Paduano L, D'Errico G, Pedone C, Morelli G
* Physicochemical Properties of Mixed Micellar Aggregates Containing CCK Peptides and Gd Complexes Designed as Tumor Specific Contrast Agents in MRI (431 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2004 Mar 17; 126(10): 3097-3107.
Impact Factor: 6.903
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Mangiapia G, Accardo A, Celso FL, Tesauro D, Morelli G, Radulescu A, Paduano L
* Mixed micelles composed of peptides and gadolinium complexes as tumor-specific contrast agents in MRI: A sans study (563 views)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2004; 108(45): 17611-17617.
Impact Factor: 3.834
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* A snapshot of the vast array of diamagnetic CEST MRI contrast agents (4 views)
Nmr Biomed (ISSN: 0952-3480linking), 2022 Feb 20; N/D: e4715-N/D.
Impact Factor: 4.044
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Consolino L, Irrera P, Romdhane F, Anemone A, Longo DL
* Investigating plasma volume expanders as novel macromolecular MRI-CEST contrast agents for tumor contrast-enhanced imaging (18 views)
Magn Reson Med (ISSN: 0740-3194linking, 1522-2594electronic), 2021 Aug; 86(2): 995-1007.
Impact Factor: 3.635
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Garello F, Boido M, Miglietti M, Bitonto V, Zenzola M, Filippi M, Arena F, Consolino L, Ghibaudi M, Terreno E
* Imaging of Inflammation in Spinal Cord Injury: Novel Insights on the Usage of PFC-Based Contrast Agents (15 views)
Biomedicines (ISSN: 2227-9059linking), 2021 Apr 3; 9(4): N/D-N/D.
Impact Factor: 4.757
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Baroni S, Stefania R, Broche LM, Senn N, Lurie DJ, Ross PJ, Aime S, Geninatti Crich S
* A Novel Class of (1) H-MRI Contrast Agents Based on the Relaxation Enhancement Induced on Water Protons by (14) N-Containing Imidazole Moieties (67 views)
Angew Chem Int Ed (ISSN: 1433-7851linking, 1521-3773electronic), 2021 Feb 19; 60(8): 4208-4214.
Impact Factor: 12.959
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Kim H, Wu Y, Villano D, Longo DL, Mcmahon MT, Sun PZ
* Analysis Protocol for the Quantification of Renal pH Using Chemical Exchange Saturation Transfer (CEST) MRI (21 views)
Methods Mol Biol (ISSN: 1064-3745linking, 1940-6029electronic), 2021; 2216: 667-688.
Impact Factor: 1.17
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Pedersen M, Irrera P, Dastrù W, Zöllner FG, Bennett KM, Beeman SC, Bretthorst GL, Garbow JR, Longo DL
* Dynamic Contrast Enhancement (DCE) MRI-Derived Renal Perfusion and Filtration: Basic Concepts (16 views)
Methods Mol Biol (ISSN: 1064-3745linking, 1940-6029electronic), 2021; 2216: 205-227.
Impact Factor: 1.17
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Siciliano G, Corricelli M, Iacobazzi RM, Canepa F, Comegna D, Fanizza E, Del Gatto A, Saviano M, Laquintana V, Comparelli R, Mascolo G, Murgolo S, Striccoli M, Agostiano A, Denora N, Zaccaro L, Curri ML, Depalo N
* Gold-Speckled SPION@SiO(2) Nanoparticles Decorated with Thiocarbohydrates for ASGPR1 Targeting: Towards HCC Dual Mode Imaging Potential Applications (84 views)
Chemistry (ISSN: 0947-6539linking, 1521-3765electronic), 2020 Aug 26; 26(48): 11048-11059.
Impact Factor: 4.857
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Tear LR, Carrera C, Gianolio E, Aime S
* Towards an Improved Design of MRI Contrast Agents: Synthesis and Relaxometric Characterisation of Gd-HPDO3A Analogues (60 views)
Chemistry (ISSN: 0947-6539linking, 1521-3765electronic), 2020 May 12; 26(27): 6056-6063.
Impact Factor: 4.857
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Baroni S, Ruggiero MR, Bitonto V, Broche LM, Lurie DJ, Aime S, Geninatti Crich S
* In vivo assessment of tumour associated macrophages in murine melanoma obtained by low-field relaxometry in the presence of iron oxide particles (173 views)
Biomaterials (ISSN: 0142-9612linking, 1878-5905electronic), 2020 Jan 27; 236: 119805-119805.
Impact Factor: 7.883
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Granato L, Longo D, Boutry S, Vander Elst L, Henoumont C, Aime S, Muller RN, Laurent S
* Synthesis and Relaxometric Characterization of New Poly[N, N-bis(3-aminopropyl)glycine] (PAPGly) Dendrons Gd-Based Contrast Agents and Their in Vivo Study by Using the Dynamic Contrast-Enhanced MRI Technique at Low Field (1 T) (123 views)
Chem Biodivers (ISSN: 1612-1872linking), 2019 Nov; 16(11): e1900322-e1900322.
Impact Factor: 1.449
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Gargiulo S, Albanese S, Mancini M
* State-of-the-Art Preclinical Photoacoustic Imaging in Oncology: Recent Advances in Cancer Theranostics (197 views)
Contrast Media Mol Imaging (ISSN: 1555-4309linking, 1555-4317electronic), 2019 Apr 30; 2019: 5080267-5080267.
Impact Factor: 1.984
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Cocozza S, Pontillo G, Lanzillo R, Russo C, Petracca M, Di Stasi M, Paolella C, Vola EA, Criscuolo C, Moccia M, Lamberti A, Monti S, Brescia Morra V, Elefante A, Palma G, Tedeschi E, Brunetti A
* MRI features suggestive of gadolinium retention do not correlate with Expanded Disability Status Scale worsening in Multiple Sclerosis (271 views)
Neuroradiology (ISSN: 0028-3940linking, 1432-1920electronic), 2019 Feb; 61(2): 155-162.
Impact Factor: 1.287
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Baroni S, Ruggiero MR, Aime S, Geninatti Crich S
* Exploring the tumour extracellular matrix by in vivo Fast Field Cycling relaxometry after the administration of a Gadolinium-based MRI contrast agent (232 views)
Magn Reson Chem (ISSN: 0749-1581linking), 2019 Jan 24; N/D: N/D-N/D.
Impact Factor: 1.601
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Gargiulo S, Albanese S, Mancini M
* State of the art preclinical photoacoustic imaging: recent advances in cancer theranostics (170 views)
Contrast Media & Molecular Imaging, 2019; 2019: Article-Article.
Impact Factor: 2.934
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Dastru W, Menchise V, Ferrauto G, Fabretto S, Carrera C, Terreno E, Aime S, Delli Castelli D
* Modulation of the Prototropic Exchange Rate in pH-Responsive Yb-HPDO3A Derivatives as ParaCEST Agents (198 views)
Chemistryselect (ISSN: 2365-6549), 2018 Jun; 3(22): 6035-6041.
Impact Factor: 1.505
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Di Gregorio E, Ferrauto G, Furlan C, Lanzardo S, Nuzzi R, Gianolio E, Aime S
* The Issue of Gadolinium Retained in Tissues: Insights on the Role of Metal Complex Stability by Comparing Metal Uptake in Murine Tissues Upon the Concomitant Administration of Lanthanum- and Gadolinium-Diethylentriamminopentaacetate (187 views)
Invest Radiol (ISSN: 1536-0210electronic, 0020-9996linking), 2018 Mar; 53(3): 167-172.
Impact Factor: 4.85
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Gianolio E, Bardini P, Arena F, Stefania R, Di Gregorio E, Iani R, Aime S
* Gadolinium Retention in the Rat Brain: Assessment of the Amounts of Insoluble Gadolinium-containing Species and Intact Gadolinium Complexes after Repeated Administration of Gadolinium-based Contrast Agents (305 views)
Radiology (ISSN: 0033-8419, 1527-1315), 2017 Dec; 285(3): 839-849.
Impact Factor: 7.469
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Torino E, Auletta L, Vecchione D, Orlandella FM, Salvatore G, Iaccino E, Fiorenza D, Grimaldi AM, Sandomenico A, Albanese S, Sarnataro D, Gramanzini M, Palmieri C, Scala G, Quinto I, Netti PA, Salvatore M, Greco A
* Multimodal imaging for a theranostic approach in a murine model of B-cell lymphoma with engineered nanoparticles (275 views) (PDF 160 views)
Nanomedicine (ISSN: 1549-9634, 1549-9642), 2017 Nov 22; 14(2): 483-491.
Impact Factor: 6.5
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Albanese S, Greco A, Auletta L, Mancini M
* Mouse models of neurodegenerative disease: preclinical imaging and neurovascular component (303 views)
Brain Imaging Behav (ISSN: 1931-7557), 2017 Oct 26; N/D: N/D-N/D.
Impact Factor: 3.719
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Longo DL, Stefania R, Aime S, Oraevsky A
* Melanin-Based Contrast Agents for Biomedical Optoacoustic Imaging and Theranostic Applications (276 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2017 Aug 7; 18(8): N/D-N/D.
Impact Factor: 3.687
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Filippi M, Catanzaro V, Patrucco D, Botta M, Tei L, Terreno E
* First in vivo MRI study on theranostic dendrimersomes (264 views)
J Control Release (ISSN: 0168-3659), 2017 Feb 28; 248: 45-52.
Impact Factor: 7.877
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Longo DL, Moustaghfir FZ, Zerbo A, Consolino L, Anemone A, Bracesco M, Aime S
* EXCI-CEST: Exploiting pharmaceutical excipients as MRI-CEST contrast agents for tumor imaging (375 views)
Int J Pharm (ISSN: 0378-5173, 1873-3476), 2017; 525(1): 275-281.
Impact Factor: 3.862
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Filippi M, Boido M, Pasquino C, Garello F, Boffa C, Terreno E
* Successful in vivo MRI tracking of MSCs labeled with Gadoteridol in a Spinal Cord Injury experimental model (261 views)
Exp Neurol (ISSN: 0014-4886), 2016 Aug; 282: 66-77.
Impact Factor: 4.706
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Tedeschi E, Palma G, Canna A, Cocozza S, Russo C, Borrelli P, Lanzillo R, Angelini V, Postiglione E, Morra VB, Salvatore M, Brunetti A, Quarantelli M
* In vivo dentate nucleus MRI relaxometry correlates with previous administration of Gadolinium-based contrast agents (421 views)
Eur Radiol (ISSN: 0938-7994, 1432-1084electronic, 0938-7994linking), 2016 Feb 23; 26(12): 4577-4584.
Impact Factor: 3.967
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Accardo A, Arena F, Gianolio E, Marasco D, Ringhieri P, Boffa C, Bardini P, Aime S, Morelli G
* Diolein based nanostructures as targeted theranostics (416 views)
J Biomed Nanotechnol (ISSN: 1550-7033), 2016; 12(5): 1076-1088.
Impact Factor: 4.521
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Consolino L, Longo DL, Dastrù W, Cutrin JC, Dettori D, Lanzardo S, Oliviero S, Cavallo F, Aime S
* Functional imaging of the angiogenic switch in a transgenic mouse model of human breast cancer by dynamic contrast enhanced magnetic resonance imaging (274 views)
Int J Cancer (ISSN: 0020-7136), 2016; N/D: N/D-N/D.
Impact Factor: 6.513
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Delli Castelli D, Ferrauto G, Di Gregorio E, Terreno E, Aime S
* Sensitive MRI detection of internalized T contrast agents using magnetization transfer contrast (221 views)
Nmr Biomed (ISSN: 0952-3480, 1099-1492electronic, 0952-3480linking), 2015 Oct 16; N/D: N/D-N/D.
Impact Factor: 2.983
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Longo DL, Michelotti F, Consolino L, Bardini P, Digilio G, Xiao G, Sun PZ, Aime S
* In Vitro and In Vivo Assessment of Nonionic Iodinated Radiographic Molecules as Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Tumor Perfusion Agents (263 views)
Invest Radiol (ISSN: 0020-9996, 1536-0210, 1536-0210electronic), 2015 Oct 12; 51(3): 155-162.
Impact Factor: 4.887
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Verberne HJ, Acampa W, Anagnostopoulos C, Ballinger J, Bengel F, De Bondt P, Buechel RR, Cuocolo A, van Eck-Smit BL, Flotats A, Hacker M, Hindorf C, Kaufmann PA, Lindner O, Ljungberg M, Lonsdale M, Manrique A, Minarik D, Scholte AJ, Slart RH, Tragardh E, de Wit TC, Hesse B
* EANM procedural guidelines for radionuclide myocardial perfusion imaging with SPECT and SPECT/CT: 2015 revision (344 views) (PDF 212 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 1619-7070print), 2015 Aug 21; 42(12): 1929-1940.
Impact Factor: 5.537
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Longo DL, Sun PZ, Consolino L, Michelotti FC, Uggeri F, Aime S
* A general MRI-CEST ratiometric approach for pH imaging: demonstration of in vivo pH mapping with iobitridol (320 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 0002-7863print), 2014 Oct 15; 136(41): 14333-14336.
Impact Factor: 12.113
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Accardo A, Ringhieri P, Szekely N, Pipich V, Luchini A, Paduano L, Tesauro D
* Structural insights on nanoparticles containing gadolinium complexes as potential theranostic (410 views)
Colloid Polym Sci (ISSN: 0303-402x), 2014 May; 292(5): 1121-1127.
Impact Factor: 1.865
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Nande R, Greco A, Gossman MS, Lopez JP, Claudio L, Salvatore M, Brunetti A, Denvir J, Howard CM, Claudio PP
* Microbubble-assisted p53, RB, and p130 gene transfer in combination with radiation therapy in prostate cancer (430 views)
Current Gene Therapy (ISSN: 1875-5631, 1566-5232), 2013 Jun 1; 13(3): 163-174.
Impact Factor: 4.906
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Accardo A, Gianolio E, Arena F, Barnert S, Schubert R, Tesauro D, Morelli G
* Nanostructures based on monoolein or diolein and amphiphilic gadolinium complexes as MRI contrast agents (382 views)
J Mater Chem B (ISSN: 2050-7518, 2050-750x), 2013; 1(5): 617-628.
Impact Factor: 8.535
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Gringeri CV, Menchise V, Rizzitelli S, Cittadino E, Catanzaro V, Dati G, Chaabane L, Digilio G, Aime S
* Novel Gd(III)-based probes for MR molecular imaging of matrix metalloproteinases (453 views)
Contrast Media Mol Imaging (ISSN: 1555-4309, 1555-4309linking), 2012 Mar; 7(2): 175-184.
Impact Factor: 2.872
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Menchise V, Digilio G, Gianolio E, Cittadino E, Catanzaro V, Carrera C, Aime S
* MR Contrast Agents (318 views)
Mol Pharm (ISSN: 1543-8384), 2011 Sep; 8(5): 1750-1756.
Impact Factor: 4.782
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Malvindi MA, Greco A, Conversano F, Figuerola A, Corti M, Bonora M, Lascialfari A, Doumari HA, Moscardini M, Cingolani R, Gigli G, Casciaro S, Pellegrino T, Ragusa A
* MR Contrast Agents (266 views)
Small Animal Imaging, 2011 Jul 8; 21(13): 2548-2555.
Impact Factor: 1.784
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Terreno E, Boffa C, Menchise V, Fedeli F, Carrera C, Castelli DD, Digilio G, Aime S
* Gadolinium-doped LipoCEST agents: A potential novel class of dual 1H-MRI probes (332 views)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2011 Apr 28; 47(16): 4667-4669.
Impact Factor: 6.169
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Accardo A, Morisco A, Gianolio E, Tesauro D, Mangiapia G, Radulescu A, Brandt A, Morelli G
* Nanoparticles containing octreotide peptides and gadolinium complexes for MRI applications (484 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 Feb; 17(2): 154-162.
Impact Factor: 1.799
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Accardo A, Morisco A, Tesauro D, Pedone C, Morelli G
* Naposomes: A new class of peptide-derivatized, target-selective multimodal nanoparticles for imaging and therapeutic applications (400 views)
Ther Deliv (ISSN: 2041-5990), 2011 Feb; 2(2): 235-257.
Impact Factor: 0
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Casciaro S, Conversano F, Ragusa A, Malvindi MA, Franchini R, Greco A, Pellegrino T, Gigli G
* Optimal enhancement configuration of silica nanoparticles for ultrasound imaging and automatic detection at conventional diagnostic frequencies (355 views)
Invest Radiol (ISSN: 0020-9996, 1536-0210, 1536-0210electronic), 2010 Nov; 45(11): 715-724.
Impact Factor: 4.67
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Mainenti PP, Mancini M, Mainolfi C, Camera L, Maurea S, Manchia A, Tanga M, Persico F, Addeo P, D'Antonio D, Speranza A, Bucci L, Persico G, Pace L, Salvatore M
* Detection of colo-rectal liver metastases: Prospective comparison of contrast enhanced US, multidetector CT, PET/CT, and 1. 5 Tesla MR with extracellular and reticulo-endothelial cell specific contrast agents (394 views)
Abdom Imaging (ISSN: 0942-8925, 1432-0509), 2010 Oct; 35(5): 511-521.
Impact Factor: 1.95
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Greco A, Di Benedetto A, Howard CM, Kelly S, Nande R, Dementieva Y, Miranda M, Brunetti A, Salvatore M, Claudio L, Sarkar D, Dent P, Curiel DT, Fisher PB, Claudio PP
* Eradication of therapy-resistant human prostate tumors using an ultrasound-guided site-specific cancer terminator virus delivery approach (378 views)
Mol Ther (ISSN: 1525-0024e, 1525-0016linking), 2010 Feb 18; 18(2): 295-306.
Impact Factor: 7.149
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Accardo A, Tesauro D, Aloj L, Pedone C, Morelli G
* Supramolecular aggregates containing lipophilic Gd(III) complexes as contrast agents in MRI (578 views)
Coord Chem Rev (ISSN: 0010-8545), 2009 Sep; 253(17-18): 2193-2213.
Impact Factor: 11.225
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Mancini M, Greco A, Speranza A, Salvatore M
* Ultrasound molecular imaging by targeted microbubble contrast agents (392 views)
Minerva Biotecnol (ISSN: 1120-4826), 2009 Jun; 21(2): 97-110.
Impact Factor: 0.268
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Morisco A, Accardo A, Gianolio E, Tesauro D, Benedetti E, Morelli G
* Micelles derivatized with octreotide as potential target-selective contrast agents in MRI (347 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 242-250.
Impact Factor: 1.807
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Digilio G, Catanzaro V, Fedeli F, Gianolio E, Menchise V, Napolitano R, Gringeri C, Aime S
* Targeting exofacial protein thiols with Gd-III complexes. An efficient procedure for MRI cell labelling (323 views)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2009 Feb 28; (8): 893-895.
Impact Factor: 5.504
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Vaccaro M, Mangiapia G, Radulescu A, Schillen K, D'Errico G, Morelli G, Paduano L
* Colloidal particles composed of amphiphilic molecules binding gadolinium complexes and peptides as tumor-specific contrast agents in MRI: physico-chemical characterization (500 views)
Soft Matter (ISSN: 1744-683x), 2009; 5(13): 2504-2512.
Impact Factor: 4.869
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Mancini M, Speranza A, Greco A, Salvatore M
* Effects Of High Frequency Ultrasound On Echogenicity Of Ultrasound Contrast Agents Solutions (225 views)
Endocrinology, 2009; 35(8S): 221-221.
Impact Factor: 4.503
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Vaccaro M, Mangiapia G, Paduano L, Gianolio E, Accardo A, Tesauro D, Morelli G
* Structural and relaxometric characterization of peptide aggregates containing gadolinium complexes as potential selective contrast agents in MRI (545 views)
Chemphyschem (ISSN: 1439-4235, 1439-7641, 1439-7641electronic), 2007 Dec 3; 8(17): 2526-2538.
Impact Factor: 3.502
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Vaccaro M, Accardo A, D'Errico G, Schillen K, Radulescu A, Tesauro D, Morelli G, Paduano L
* Peptides and gd complexes containing colloidal assemblies as tumor-specific contrast agents in MRI: Physicochemical characterization (379 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2007 Sep; 93(5): 1736-1746.
Impact Factor: 4.627
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Tesauro D, Accardo A, Gianolio E, Paduano L, Teixeira J, Schillén K, Aime S, Morelli G
* Peptide derivatized lamellar aggregates as target-specific MRI contrast agents (556 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 25; 8(8): 950-955.
Impact Factor: 3.446
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Accardo A, Tesauro D, Morelli G, Gianolio E, Aime S, Vaccaro M, Mangiapia G, Paduano L, Schillén K
* High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI (391 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2007 Feb; 12(2): 267-276.
Impact Factor: 3.325
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Vaccaro M, Accardo A, Tesauro D, Mangiapia G, Loef D, Schillen K, Soederman O, Morelli G, Paduan L
* Supramolecular aggregates of amphiphilic gadolinium complexes as blood pool MRI/MRA contrast agents: Physicochemical characterization (381 views)
Langmuir (ISSN: 0743-7463), 2006 Jul 18; 22(15): 6635-6643.
Impact Factor: 3.902
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Cuocolo A, Acampa W, Imbriaco M, De Luca N, Iovino GL, Salvatore M
* The many ways to myocardial perfusion imaging (449 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2005 Mar; 49(1): 4-18.
Impact Factor: 1.724
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Morelli G, Accardo A, Tesauro D, Pedone C, Mangiapia G, Paduano L, Gianolio E
* Multicomponent aggregates containing the CCK8 bioactive peptide and Gd complexes as target-specific MRI contrast agents (235 views)
Peptides 2004 Proceedings, 2005; N/D: N/D-N/D.
Impact Factor: 0
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Accardo A, Tesauro D, Roscigno P, Gianolio E, Paduano L, D'Errico G, Pedone C, Morelli G
* Physicochemical Properties of Mixed Micellar Aggregates Containing CCK Peptides and Gd Complexes Designed as Tumor Specific Contrast Agents in MRI (431 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2004 Mar 17; 126(10): 3097-3107.
Impact Factor: 6.903
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Mangiapia G, Accardo A, Celso FL, Tesauro D, Morelli G, Radulescu A, Paduano L
* Mixed micelles composed of peptides and gadolinium complexes as tumor-specific contrast agents in MRI: A sans study (563 views)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2004; 108(45): 17611-17617.
Impact Factor: 3.834
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57 Records (54 excluding Abstracts).
Total impact factor: 245.203 (237.717 excluding Abstracts).
Total 5 year impact factor: 250.192 (242.198 excluding Abstracts).
Total impact factor: 245.203 (237.717 excluding Abstracts).
Total 5 year impact factor: 250.192 (242.198 excluding Abstracts).
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