MRI Tracking of Macrophages Labeled with Glucan Particles Entrapping perfluorocarbons based nanoparticles
Contact person Contatto: Valeria Menchise, valeria.menchise
unito.it
Actors Attori: Valeria Menchise, valeria.menchiseunito.it,
Research areas Aree di ricerca: Preclinical Imaging Imaging Preclinico,
Contact person Contatto: Valeria Menchise, valeria.menchise
unito.itActors Attori: Valeria Menchise, valeria.menchise
unito.it, Description Descrizione:
The most used
class of MRI probes for cellular imaging is represented by iron oxide
nanoparticles (IONPs). Even if they succeeded at both preclinical and clinical
levels in many cases, the negative constrast they produce as T2 or T2*
contrast agents may be a drawback, making an unambiguous detection of the
labelled cells very challenging especially in organs with an intrinsically low
MRI signal (e.g. lung, bones) or in the presence of haemorrhages. In addition,
the contrast generated by IONP-labelled cells is linearly correlated to the
cells number only at low iron concentrations.
A new emerging
approach for cellular MRI is based on agents containing fluorine (19F,
100% natural abundance). 19F-based MRI has gained huge attention in
the last 20 years, owing to the possibility to obtain quantitative information
in a diagnostic MR protocol because of the absence of background signal allows
specific and selective detection of the administrated 19F-containing
probes in vivo. Moreover, the
chemical shift of 19F is spread out over a wide range, thus allowing
the selective observation of different agents present in the same anatomical
district. The 19F-containing contrast agents studied so far are
mostly nanosized.
Because of their
high payload of 19F atoms, perfluorocarbons (PFCs), under the form of
nanoemulsions, are the most frequently used 19F-MRI contrast agents for
biological applications. Recent studies have demonstrated the potential of PFCs
to label and image cells (mostly phagocytic) either in vitro or in vivo
and have demonstratedthe the potential
of cellular 19F-MRI, especially for quantifying the number of labelled cells.
This research project is focused on the
development of a labelling procedure based on Glucan Particles (GPs), a high
potential biocompatible microcarriers in the molecular imaging field, loaded
with perfluoro-crown-ether. Our data showed that the use of loaded GPs improved
substantially the labelling efficiency of macrophages in 19F-MRI
cellular imaging experiments in vitro. Further studies are in due course with
the main goal to demonstrate the performance of PFCs-loaded GPs for the visualization
and the tracking of the macrophage recruitment in an animal model.
Figures Figure:
Selected papers Lavori selezionati:
Menchise,
V., Digilio, G., Gianolio,
E., Catanzaro, V., Carrera, C.,
Aime, S. In Vivo Labeling of B16 Melanoma Tumor Xenograft with a Thiol-Reactive
Gadolinium Based MRI Contrast Agent Molecular Pharmaceutics (2011)
1750-1756 DOI: 10.1021/mp2001044.
Catanzaro, C., Gringeri, C. V.,
Menchise, V., Padovan, S., Boffa, C., Dastrù, W., Chaabane, L., Digilio, G.,
Aime, S. A R2p/R1p ratiometric procedure to assess Matrix Metalloproteinase-2 activity
by Magnetic Resonance Imaging. Angew. Chem. Int. (2013), 52, 3926–3930. (DOI:
10.1002/anie.201209286).
Figueiredo, S., Cutrin, J.C., Rizzitelli, S., De
Luca, E., Moreira, J.N., Geraldes, C.F., Aime, S., Terreno, E. MRI tracking of macrophages labeled with glucan particles entrapping a
water insoluble paramagnetic Gd-based agent. Mol Imaging Biol. 2013;15:307-15.
Rizzitelli, S., Giustetto, P.,
Cutrin, J.C., Delli Castelli, D., Boffa, C., Ruzza, M., Menchise, V., Molinari,
F., Aime, S., Terreno, E. Sonosensitive theranostic liposomes for preclinical
in vivo MRI-guided visualization of doxorubicin release stimulated by pulsed
low intensity non-focused ultrasound J Control Release 2015 Jan; 202C: 21-30 |
PMID: 25626083.
Chirizzi C., Menchise, V., Delli Castelli, D., Dastrù, W., Aime. S. and
Terreno, E. Glucan Particles Loaded with Fluorinated Emulsions: a Sensitivity
Improvement for the Visualization of Phagocytic Cells by 19F-MRI 2015 submitted
to Current Molecular Imaging.
MRI Tracking of Macrophages Labeled with Glucan Particles Entrapping perfluorocarbons based nanoparticles 
| ▼ Imaging Tumor Acidosis |
MRI Tracking of Macrophages Labeled with Glucan Particles Entrapping perfluorocarbons based nanoparticles
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Dettagli Esporta in BibTeX Esporta in EndNote
Longo DL, Michelotti F, Consolino L, Bardini P, Digilio G, Xiao G, Sun PZ, Aime S
* In Vitro and In Vivo Assessment of Nonionic Iodinated Radiographic Molecules as Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Tumor Perfusion Agents (242 visite)
Invest Radiol (ISSN: 0020-9996, 1536-0210, 1536-0210electronic), 2015 Oct 12; 51(3): 155-162.
Impact Factor: 4.887
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Verberne HJ, Acampa W, Anagnostopoulos C, Ballinger J, Bengel F, De Bondt P, Buechel RR, Cuocolo A, van Eck-Smit BL, Flotats A, Hacker M, Hindorf C, Kaufmann PA, Lindner O, Ljungberg M, Lonsdale M, Manrique A, Minarik D, Scholte AJ, Slart RH, Tragardh E, de Wit TC, Hesse B
* EANM procedural guidelines for radionuclide myocardial perfusion imaging with SPECT and SPECT/CT: 2015 revision (327 visite) (PDF 206 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 1619-7070print), 2015 Aug 21; 42(12): 1929-1940.
Impact Factor: 5.537
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Longo DL, Sun PZ, Consolino L, Michelotti FC, Uggeri F, Aime S
* A general MRI-CEST ratiometric approach for pH imaging: demonstration of in vivo pH mapping with iobitridol (301 visite)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 0002-7863print), 2014 Oct 15; 136(41): 14333-14336.
Impact Factor: 12.113
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Nande R, Greco A, Gossman MS, Lopez JP, Claudio L, Salvatore M, Brunetti A, Denvir J, Howard CM, Claudio PP
* Microbubble-assisted p53, RB, and p130 gene transfer in combination with radiation therapy in prostate cancer (402 visite)
Current Gene Therapy (ISSN: 1875-5631, 1566-5232), 2013 Jun 1; 13(3): 163-174.
Impact Factor: 4.906
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Accardo A, Gianolio E, Arena F, Barnert S, Schubert R, Tesauro D, Morelli G
* Nanostructures based on monoolein or diolein and amphiphilic gadolinium complexes as MRI contrast agents (360 visite)
J Mater Chem B (ISSN: 2050-7518, 2050-750x), 2013; 1(5): 617-628.
Impact Factor: 8.535
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Gringeri CV, Menchise V, Rizzitelli S, Cittadino E, Catanzaro V, Dati G, Chaabane L, Digilio G, Aime S
* Novel Gd(III)-based probes for MR molecular imaging of matrix metalloproteinases (426 visite)
Contrast Media Mol Imaging (ISSN: 1555-4309, 1555-4309linking), 2012 Mar; 7(2): 175-184.
Impact Factor: 2.872
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Menchise V, Digilio G, Gianolio E, Cittadino E, Catanzaro V, Carrera C, Aime S
* MR Contrast Agents (296 visite)
Mol Pharm (ISSN: 1543-8384), 2011 Sep; 8(5): 1750-1756.
Impact Factor: 4.782
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Malvindi MA, Greco A, Conversano F, Figuerola A, Corti M, Bonora M, Lascialfari A, Doumari HA, Moscardini M, Cingolani R, Gigli G, Casciaro S, Pellegrino T, Ragusa A
* MR Contrast Agents (248 visite)
Small Animal Imaging, 2011 Jul 8; 21(13): 2548-2555.
Impact Factor: 1.784
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Terreno E, Boffa C, Menchise V, Fedeli F, Carrera C, Castelli DD, Digilio G, Aime S
* Gadolinium-doped LipoCEST agents: A potential novel class of dual 1H-MRI probes (309 visite)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2011 Apr 28; 47(16): 4667-4669.
Impact Factor: 6.169
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Accardo A, Morisco A, Tesauro D, Pedone C, Morelli G
* Naposomes: A new class of peptide-derivatized, target-selective multimodal nanoparticles for imaging and therapeutic applications (376 visite)
Ther Deliv (ISSN: 2041-5990), 2011 Feb; 2(2): 235-257.
Impact Factor: 0
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Casciaro S, Conversano F, Ragusa A, Malvindi MA, Franchini R, Greco A, Pellegrino T, Gigli G
* Optimal enhancement configuration of silica nanoparticles for ultrasound imaging and automatic detection at conventional diagnostic frequencies (330 visite)
Invest Radiol (ISSN: 0020-9996, 1536-0210, 1536-0210electronic), 2010 Nov; 45(11): 715-724.
Impact Factor: 4.67
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Mainenti PP, Mancini M, Mainolfi C, Camera L, Maurea S, Manchia A, Tanga M, Persico F, Addeo P, D'Antonio D, Speranza A, Bucci L, Persico G, Pace L, Salvatore M
* Detection of colo-rectal liver metastases: Prospective comparison of contrast enhanced US, multidetector CT, PET/CT, and 1. 5 Tesla MR with extracellular and reticulo-endothelial cell specific contrast agents (307 visite)
Abdom Imaging (ISSN: 0942-8925, 1432-0509), 2010 Oct; 35(5): 511-521.
Impact Factor: 1.95
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Greco A, Di Benedetto A, Howard CM, Kelly S, Nande R, Dementieva Y, Miranda M, Brunetti A, Salvatore M, Claudio L, Sarkar D, Dent P, Curiel DT, Fisher PB, Claudio PP
* Eradication of therapy-resistant human prostate tumors using an ultrasound-guided site-specific cancer terminator virus delivery approach (340 visite)
Mol Ther (ISSN: 1525-0024e, 1525-0016linking), 2010 Feb 18; 18(2): 295-306.
Impact Factor: 7.149
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Accardo A, Tesauro D, Aloj L, Pedone C, Morelli G
* Supramolecular aggregates containing lipophilic Gd(III) complexes as contrast agents in MRI (484 visite)
Coord Chem Rev (ISSN: 0010-8545), 2009 Sep; 253(17-18): 2193-2213.
Impact Factor: 11.225
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Mancini M, Greco A, Speranza A, Salvatore M
* Ultrasound molecular imaging by targeted microbubble contrast agents (351 visite)
Minerva Biotecnol (ISSN: 1120-4826), 2009 Jun; 21(2): 97-110.
Impact Factor: 0.268
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Morisco A, Accardo A, Gianolio E, Tesauro D, Benedetti E, Morelli G
* Micelles derivatized with octreotide as potential target-selective contrast agents in MRI (312 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 242-250.
Impact Factor: 1.807
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Digilio G, Catanzaro V, Fedeli F, Gianolio E, Menchise V, Napolitano R, Gringeri C, Aime S
* Targeting exofacial protein thiols with Gd-III complexes. An efficient procedure for MRI cell labelling (309 visite)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2009 Feb 28; (8): 893-895.
Impact Factor: 5.504
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Vaccaro M, Mangiapia G, Radulescu A, Schillen K, D'Errico G, Morelli G, Paduano L
* Colloidal particles composed of amphiphilic molecules binding gadolinium complexes and peptides as tumor-specific contrast agents in MRI: physico-chemical characterization (471 visite)
Soft Matter (ISSN: 1744-683x), 2009; 5(13): 2504-2512.
Impact Factor: 4.869
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Mancini M, Speranza A, Greco A, Salvatore M
* Effects Of High Frequency Ultrasound On Echogenicity Of Ultrasound Contrast Agents Solutions (213 visite)
Endocrinology, 2009; 35(8S): 221-221.
Impact Factor: 4.503
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Vaccaro M, Mangiapia G, Paduano L, Gianolio E, Accardo A, Tesauro D, Morelli G
* Structural and relaxometric characterization of peptide aggregates containing gadolinium complexes as potential selective contrast agents in MRI (487 visite)
Chemphyschem (ISSN: 1439-4235, 1439-7641, 1439-7641electronic), 2007 Dec 3; 8(17): 2526-2538.
Impact Factor: 3.502
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Vaccaro M, Accardo A, D'Errico G, Schillen K, Radulescu A, Tesauro D, Morelli G, Paduano L
* Peptides and gd complexes containing colloidal assemblies as tumor-specific contrast agents in MRI: Physicochemical characterization (360 visite)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2007 Sep; 93(5): 1736-1746.
Impact Factor: 4.627
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Tesauro D, Accardo A, Gianolio E, Paduano L, Teixeira J, Schillén K, Aime S, Morelli G
* Peptide derivatized lamellar aggregates as target-specific MRI contrast agents (408 visite)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 25; 8(8): 950-955.
Impact Factor: 3.446
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Accardo A, Tesauro D, Morelli G, Gianolio E, Aime S, Vaccaro M, Mangiapia G, Paduano L, Schillén K
* High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI (365 visite)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2007 Feb; 12(2): 267-276.
Impact Factor: 3.325
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Morelli G, Accardo A, Tesauro D, Pedone C, Mangiapia G, Paduano L, Gianolio E
* Multicomponent aggregates containing the CCK8 bioactive peptide and Gd complexes as target-specific MRI contrast agents (219 visite)
Peptides 2004 Proceedings, 2005; N/D: N/D-N/D.
Impact Factor: 0
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Accardo A, Tesauro D, Roscigno P, Gianolio E, Paduano L, D'Errico G, Pedone C, Morelli G
* Physicochemical Properties of Mixed Micellar Aggregates Containing CCK Peptides and Gd Complexes Designed as Tumor Specific Contrast Agents in MRI (401 visite)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2004 Mar 17; 126(10): 3097-3107.
Impact Factor: 6.903
Dettagli Esporta in BibTeX Esporta in EndNote
Mangiapia G, Accardo A, Celso FL, Tesauro D, Morelli G, Radulescu A, Paduano L
* Mixed micelles composed of peptides and gadolinium complexes as tumor-specific contrast agents in MRI: A sans study (539 visite)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2004; 108(45): 17611-17617.
Impact Factor: 3.834
Dettagli Esporta in BibTeX Esporta in EndNote
38 Records (35 escludendo Abstract e Conferenze).
Impact factor totale: 187.366 (179.88 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 193.351 (185.357 escludendo Abstract e Conferenze).
Impact factor totale: 187.366 (179.88 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 193.351 (185.357 escludendo Abstract e Conferenze).
Last modified by Ultima modifica di Marco Comerci on in data Thursday 11 June 2015, 15:19:54
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