Biochemical and structural insights on Chromatin Assembly Factor 1 in physio/pathological events Studi biochimici e molecolari sul Fattore di Assemblaggio della Cromatina 1 coinvolta in eventi fisiopatologici
Contact person Contatto: Simona Maria Monti, marmonti
unina.it
Actors Attori: Giuseppina De Simone, gdesimonunina.it, Vincenzo Alterio, vincenzo.alterio@ibb.cnr.it, Anna Di Fiore, anna.difiorecnr.it, Katia D'Ambrosio, katia.dambrosiocnr.it, Martina Buonanno, martina.buonannocnr.it, Emma Langella, emma.langellacnr.it, Simona Maria Monti, marmontiunina.it,
Research areas Aree di ricerca: Structure and function of proteins involved in physio-pathologic processes Struttura e funzione di proteine coinvolte in processi fisiopatologici, Macromolecules for biomedical and biotechnological applications Macromolecole per applicazioni biomediche e biotecnologiche,
Keywords Parole chiave: Caf 1, Dna Replication, Dna Repair, Nucleosome Assembly, P150, Chromatin Assembly Factor 1
Contact person Contatto: Simona Maria Monti, marmonti
unina.itActors Attori: Giuseppina De Simone, gdesimon
unina.it, Vincenzo Alterio, vincenzo.alterio@ibb.cnr.it, Anna Di Fiore, anna.difiorecnr.it, Katia D'Ambrosio, katia.dambrosiocnr.it, Martina Buonanno, martina.buonannocnr.it, Emma Langella, emma.langellacnr.it, Simona Maria Monti, marmontiunina.it, Description Descrizione:
The Chromatin Assembly Factor 1 is a heterotrimeric complex responsible for the nucleosome assembly during DNA replication and DNA repair. It consists of three subunits named according to their molecular weight: P150, P60, and P48. There is great interest towards these components, with particular regards to P150 which was recently considered as a tumor-associated protein due to its overexpression in many malignancies and P60 which is a marker for poor prognosis in many human malignancies. Despite their importance, structural and functional studies targeting P150 and P60 are still limited and only scarce information about these subunits are available. Insights into the biochemical, structural and functional features of this subunit are currently underway by means of different tools. Results can help to better understand the molecular mechanism of the nucleosome assembly and to correlate its features to human cancer. Il Fattore di Assemblaggio della Cromatina 1 (CAF1) è un complesso eterotrimeri coresponsabile dell'assemblaggio del nucleosoma durante la replicazione e la riparazione del DNA. Esso consiste di tre subunità denominate in base al loro peso molecolare: P150, P60 e P48. Attualmente vi è un forte interesse verso queste componenti con particolare riguardo a P150, che è stata recentemente considerata come una proteina associata ai tumori a causa della sua sovraespressione in molti tumori maligni, e a P60 che è un marker di prognosi sfavorevole in molte neoplasie umane. Malgrado ciò, attualmente sono ancora scarse le informazioni strutturali e funzionali su entrambe le subunità che sono oggetto di studio nel nostro Istituto. Attraverso l’impiego di diversi approcci quali studi in silico, biochimici e strutturali a raggi X sono stati ottenuti importanti risultati sulle caratteristiche biochimiche, strutturali e funzionali di P150 e P60 che possono aiutare a comprendere meglio il meccanismo molecolare dell'assemblaggio dei nucleosomi e a correlare le loro funzioni ad alcune patologie tumorali umane.
The Chromatin Assembly Factor 1 is a heterotrimeric complex responsible for the nucleosome assembly during DNA replication and DNA repair. It consists of three subunits named according to their molecular weight: P150, P60, and P48. There is great interest towards these components, with particular regards to P150 which was recently considered as a tumor-associated protein due to its overexpression in many malignancies and P60 which is a marker for poor prognosis in many human malignancies. Despite their importance, structural and functional studies targeting P150 and P60 are still limited and only scarce information about these subunits are available. Insights into the biochemical, structural and functional features of this subunit are currently underway by means of different tools. Results can help to better understand the molecular mechanism of the nucleosome assembly and to correlate its features to human cancer. Il Fattore di Assemblaggio della Cromatina 1 (CAF1) è un complesso eterotrimeri coresponsabile dell'assemblaggio del nucleosoma durante la replicazione e la riparazione del DNA. Esso consiste di tre subunità denominate in base al loro peso molecolare: P150, P60 e P48. Attualmente vi è un forte interesse verso queste componenti con particolare riguardo a P150, che è stata recentemente considerata come una proteina associata ai tumori a causa della sua sovraespressione in molti tumori maligni, e a P60 che è un marker di prognosi sfavorevole in molte neoplasie umane. Malgrado ciò, attualmente sono ancora scarse le informazioni strutturali e funzionali su entrambe le subunità che sono oggetto di studio nel nostro Istituto. Attraverso l’impiego di diversi approcci quali studi in silico, biochimici e strutturali a raggi X sono stati ottenuti importanti risultati sulle caratteristiche biochimiche, strutturali e funzionali di P150 e P60 che possono aiutare a comprendere meglio il meccanismo molecolare dell'assemblaggio dei nucleosomi e a correlare le loro funzioni ad alcune patologie tumorali umane.
Biochemical and structural insights on Chromatin Assembly Factor 1 in physio/pathological events Studi biochimici e molecolari sul Fattore di Assemblaggio della Cromatina 1 coinvolta in eventi fisiopatologici
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Biochemical and structural insights on Chromatin Assembly Factor 1 in physio/pathological events Studi biochimici e molecolari sul Fattore di Assemblaggio della Cromatina 1 coinvolta in eventi fisiopatologici
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Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA
* The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (429 visite)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
Impact Factor: 4.823
Dettagli Esporta in BibTeX Esporta in EndNote
Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
* The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (433 visite)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
Impact Factor: 3.078
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Messere A, Fabbri E, Borgatti M, Gambari R, Di Blasio B, Pedone C, Romanelli A
* Antiproliferative activity of Pt(II) and Pd(II) phosphine complexes with thymine and thymidine (281 visite)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2007 Feb; 101(2): 254-260.
Impact Factor: 3.663
Dettagli Esporta in BibTeX Esporta in EndNote
Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
* Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (446 visite)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2006; 26(43): 10949-10957.
Impact Factor: 2.117
Dettagli Esporta in BibTeX Esporta in EndNote
Herscher LL, Cook JA, Pacelli R, Pass HI, Russo A, Mitchell JB
Principles of chemoradiation: Theoretical and practical considerations (379 visite)
Oncology (ISSN: 0890-9091), 1999 Oct; 13(10SUPPL.5): 11-22.
Impact Factor: 0.933
Dettagli Esporta in BibTeX Esporta in EndNote
Cook JA, Krishna MC, Pacelli R, DeGraff W, Liebmann J, Mitchell JB, Russo A, Wink DA
Nitric oxide enhancement of melphalan-induced cytotoxicity (449 visite)
Br J Cancer (ISSN: 0007-0920, 0007-0920print, 0007-0920linking), 1997 Sep; 76(3): 325-334.
Impact Factor: 2.938
Dettagli Esporta in BibTeX Esporta in EndNote
27 Records (26 escludendo Abstract e Conferenze).
Impact factor totale: 101.828 (98.098 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 101.965 (97.721 escludendo Abstract e Conferenze).
Last modified by Ultima modifica di Marco Comerci on in data Monday 07 December 2020, 11:55:37
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