Plant polypeptides as natural enhancers of biostimulation Polipeptidi vegetali come potenziatori naturali della biostimolazione
Contact person Contatto: Simona Maria Monti, marmonti
unina.it
Actors Attori: Martina Buonanno, martina.buonannocnr.it, Emma Langella, emma.langellacnr.it, Simona Maria Monti, marmontiunina.it,
Research areas Aree di ricerca: Small molecules and peptides/modified peptides for diagnostic, therapeutic and biotechnological applications Piccole molecole e peptidi/peptidi modificati per applicazioni diagnostiche, terapeutiche e biotecnologiche, Macromolecules for biomedical and biotechnological applications Macromolecole per applicazioni biomediche e biotecnologiche,
Keywords Parole chiave: Prosystemin, Biotic And Abiotic Stress, Plant Defence, Food And Health, Intrinsically Disordered Protein
Contact person Contatto: Simona Maria Monti, marmonti
unina.itActors Attori: Martina Buonanno, martina.buonanno
cnr.it, Emma Langella, emma.langellacnr.it, Simona Maria Monti, marmontiunina.it, Description Descrizione:
Plants cannot escape adverse environmental changes and have developed very efficient defense responses against stress agents. The molecular mechanisms underlying defense responses against insect attack are activated locally, at the damaged site, and promote a long-distance signaling largely modulated by jasmonic acid. Wound damage results both in local and systemic expression of proteinase inhibitors(PIs), disrupting the digestion of feeding insects. In tomato, these events are triggered by a peptide hormone named Systemin. The signaling molecule is an octadeca peptide intensely investigated over the years which, upon wounding, is released from the C-terminal region of a larger pro-hormone of 200 amino acids called Prosystemin (Prosys). Prosys gene is transcribed at low level in physiological conditions, while its expression is enhanced by mechanical wounding or feeding by herbivore insects. The observation that Prosys elicits multiple defense pathways to protect tomato plants against a wide range of stress agent suggested that it could play a role in plant defense broader than expected. Bymeans of biochemical and in silico studies we performed a structural and biochemical characterization of Prosys which provedthat it is a member of the Intrinsically Disordered Proteins (IDPs) family.IDPs are a class of proteins completely or only partially unstructured but still functionally active. These results, which contribute to increase theunderstanding of the multiple roles of Prosys in the defense mechanisms, pavethe way for innovative crop protection for sustainable agriculture with beneficial effects on human health.
Plants cannot escape adverse environmental changes and have developed very efficient defense responses against stress agents. The molecular mechanisms underlying defense responses against insect attack are activated locally, at the damaged site, and promote a long-distance signaling largely modulated by jasmonic acid. Wound damage results both in local and systemic expression of proteinase inhibitors(PIs), disrupting the digestion of feeding insects. In tomato, these events are triggered by a peptide hormone named Systemin. The signaling molecule is an octadeca peptide intensely investigated over the years which, upon wounding, is released from the C-terminal region of a larger pro-hormone of 200 amino acids called Prosystemin (Prosys). Prosys gene is transcribed at low level in physiological conditions, while its expression is enhanced by mechanical wounding or feeding by herbivore insects. The observation that Prosys elicits multiple defense pathways to protect tomato plants against a wide range of stress agent suggested that it could play a role in plant defense broader than expected. Bymeans of biochemical and in silico studies we performed a structural and biochemical characterization of Prosys which provedthat it is a member of the Intrinsically Disordered Proteins (IDPs) family.IDPs are a class of proteins completely or only partially unstructured but still functionally active. These results, which contribute to increase theunderstanding of the multiple roles of Prosys in the defense mechanisms, pavethe way for innovative crop protection for sustainable agriculture with beneficial effects on human health.
Selected papers Lavori selezionati:
Prosystemin, a prohormone that modulates plant defensebarriers, is an intrinsically disordered protein.
Protein Sci. 2018Mar;27(3):620-632.
Plant polypeptides as natural enhancers of biostimulation Polipeptidi vegetali come potenziatori naturali della biostimolazione
Plant polypeptides as natural enhancers of biostimulation Polipeptidi vegetali come potenziatori naturali della biostimolazione
Search related bibliography on PubMed Cerca bibliografia collegata su PubMed
Langella E, Buonanno M, De Simone G, Monti SM
* Intrinsically disordered features of carbonic anhydrase IX proteoglycan-like domain (14 visite)
Cell Mol Life Sci (ISSN: 1420-682xlinking), 2021 Mar; 78(5): 2059-2067.
Impact Factor: 9.261
Dettagli Esporta in BibTeX Esporta in EndNote
Monti SM, De Simone G, Langella E
* The Amazing World of IDPs in Human Diseases (12 visite)
Biomolecules (ISSN: 2218-273xlinking), 2021 Feb 23; 11(2): N/D-N/D.
Impact Factor: 4.879
Dettagli Esporta in BibTeX Esporta in EndNote
La Rosa C, Condorelli M, Compagnini G, Lolicato F, Milardi D, Do TN, Karttunen M, Pannuzzo M, Ramamoorthy A, Fraternali F, Collu F, Rezaei H, Strodel B, Raudino A
* Symmetry-breaking transitions in the early steps of protein self-assembly (63 visite)
Eur Biophys J (ISSN: 0175-7571linking), 2020 Mar; 49(2): 175-191.
Impact Factor: 2.094
Dettagli Esporta in BibTeX Esporta in EndNote
Vincenzi M, Mercurio FA, Leone M
* About TFE: Old and New Findings (84 visite)
Curr Protein Pept Sci (ISSN: 1389-2037linking), 2019; 20 (5 ): 425-451.
Impact Factor:
Dettagli Esporta in BibTeX Esporta in EndNote
Scollo F, Tempra C, Lolicato F, Sciacca MFM, Raudino A, Milardi D, La Rosa C
* Phospholipids Critical Micellar Concentrations Trigger Different Mechanisms of Intrinsically Disordered Proteins Interaction with Model Membranes (272 visite) (PDF 111 visite)
J Phys Chem Lett (ISSN: 1948-7185electronic, 1948-7185linking), 2018 Sep 6; 9(17): 5125-5129.
Impact Factor: 6.687
Dettagli Esporta in BibTeX Esporta in EndNote
Langella E, Buonanno M, Vullo D, Dathan N, Leone M, Supuran C, De Simone G, Monti SM
* Biochemical, biophysical and molecular dynamics studies on the proteoglycan-like domain of carbonic anhydrase IX (295 visite)
Cell Mol Life Sci (ISSN: 1420-682xlinking), 2018 Sep; 75(17): 3283-3296.
Impact Factor: 6.721
Dettagli Esporta in BibTeX Esporta in EndNote
Buonanno M, Coppola M, Di Lelio I, Molisso D, Leone M, Pennacchio F, Langella E, Rao R, Monti SM
* Prosystemin, a prohormone that modulates plant defense barriers, is an intrinsically disordered protein (328 visite)
Protein Sci (ISSN: 1469-896xelectronic, 0961-8368linking), 2018 Mar; 27(3): 620-632.
Impact Factor: 2.937
Dettagli Esporta in BibTeX Esporta in EndNote
Pirone L, Ripoll-rozada J, Leone M, Ronca R, Lombardo F, Fiorentino G, Andersen JF, Pereira PJB, Arcà B, Pedone E
* Functional analyses yield detailedinsight into the mechanism of thrombin inhibition by the antihemostatic salivary protein cE5 from Anopheles gambiae (327 visite) (PDF 180 visite)
Jbc Papers (ISSN: 0021-9258linking, 1083-351x), 2017 Jul 28; 292(30): 12632-12642.
Impact Factor: 4.125
Dettagli Esporta in BibTeX Esporta in EndNote
Vincenzi M, Costantini S, Scala S, Tesauro D, Accardo A, Leone M, Colonna G, Guillon J, Portella L, Trotta AM, Ronga L, Rossi F
* Conformational ensembles explored dynamically from disordered peptides targeting chemokine receptor CXCR4 (503 visite)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2015; 16(6): 12159-12173.
Impact Factor: 3.257
Dettagli Esporta in BibTeX Esporta in EndNote
Diana D, Smaldone G, De Antonellis P, Pirone L, Carotenuto M, Alonzi A, Di Gaetano S, Zollo M, Pedone E, Fattorusso R
* Mapping Functional Interaction Sites of Human Prune C-Terminal Domain by NMR Spectroscopy in Human Cell Lysates (322 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2013 Sep 9; 19(37): 12217-12220.
Impact Factor: 5.696
Dettagli Esporta in BibTeX Esporta in EndNote
Smaldone G, Falanga A, Capasso D, Guarnieri D, Correale S, Galdiero M, Netti PA, Zollo M, Galdiero S, Di Gaetano S, Pedone E
* gH625 is a viral derived peptide for effective delivery of intrinsically disordered proteins (407 visite)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1178-2013electronic), 2013; 8: 2555-2565.
Impact Factor: 4.195
Dettagli Esporta in BibTeX Esporta in EndNote
Accardo A, Leone M, Tesauro D, Aufiero R, Bénarouche A, Cavalier JF, Longhi S, Carriere F, Rossi F
* Solution conformational features and interfacial properties of an intrinsically disordered peptide coupled to alkyl chains: A new class of peptide amphiphiles (389 visite)
Mol Biosyst (ISSN: 1742-206x), 2013; 9(6): 1401-1410.
Impact Factor: 3.183
Dettagli Esporta in BibTeX Esporta in EndNote
Di Maro A, Berisio R, Ruggiero A, Tamburino R, Severino V, Zacchia E, Parente A
* Structural and enzymatic properties of an in vivo proteolytic form of PD-S2, type 1 ribosome-inactivating protein from seeds of Phytolacca dioica (332 visite)
Biochem Biophys Res Commun (ISSN: 0006-291x), 2012 May 11; 421(3): 514-520.
Impact Factor: 2.406
Dettagli Esporta in BibTeX Esporta in EndNote
Ruggiero A, Chambery A, Di Maro A, Parente A, Berisio R
* Atomic Resolution (1. 1 Angstrom) Structure Of The Ribosome-Inactivating Protein Pd-L4 From Phytolacca Dioica L. Leaves (350 visite)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2008 Apr; 71(1): 8-15.
Impact Factor: 3.419
Dettagli Esporta in BibTeX Esporta in EndNote
14 Records (14 escludendo Abstract e Conferenze).
Impact factor totale: 58.86 (58.86 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 50.669 (50.669 escludendo Abstract e Conferenze).
Search related bibliography on PubMed Cerca bibliografia collegata su PubMed
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Langella E, Buonanno M, De Simone G, Monti SM
* Intrinsically disordered features of carbonic anhydrase IX proteoglycan-like domain (14 visite)
Cell Mol Life Sci (ISSN: 1420-682xlinking), 2021 Mar; 78(5): 2059-2067.
Impact Factor: 9.261
Dettagli Esporta in BibTeX Esporta in EndNote
Monti SM, De Simone G, Langella E
* The Amazing World of IDPs in Human Diseases (12 visite)
Biomolecules (ISSN: 2218-273xlinking), 2021 Feb 23; 11(2): N/D-N/D.
Impact Factor: 4.879
Dettagli Esporta in BibTeX Esporta in EndNote
La Rosa C, Condorelli M, Compagnini G, Lolicato F, Milardi D, Do TN, Karttunen M, Pannuzzo M, Ramamoorthy A, Fraternali F, Collu F, Rezaei H, Strodel B, Raudino A
* Symmetry-breaking transitions in the early steps of protein self-assembly (63 visite)
Eur Biophys J (ISSN: 0175-7571linking), 2020 Mar; 49(2): 175-191.
Impact Factor: 2.094
Dettagli Esporta in BibTeX Esporta in EndNote
Vincenzi M, Mercurio FA, Leone M
* About TFE: Old and New Findings (84 visite)
Curr Protein Pept Sci (ISSN: 1389-2037linking), 2019; 20 (5 ): 425-451.
Impact Factor:
Dettagli Esporta in BibTeX Esporta in EndNote
Scollo F, Tempra C, Lolicato F, Sciacca MFM, Raudino A, Milardi D, La Rosa C
* Phospholipids Critical Micellar Concentrations Trigger Different Mechanisms of Intrinsically Disordered Proteins Interaction with Model Membranes (272 visite) (PDF 111 visite)
J Phys Chem Lett (ISSN: 1948-7185electronic, 1948-7185linking), 2018 Sep 6; 9(17): 5125-5129.
Impact Factor: 6.687
Dettagli Esporta in BibTeX Esporta in EndNote
Langella E, Buonanno M, Vullo D, Dathan N, Leone M, Supuran C, De Simone G, Monti SM
* Biochemical, biophysical and molecular dynamics studies on the proteoglycan-like domain of carbonic anhydrase IX (295 visite)
Cell Mol Life Sci (ISSN: 1420-682xlinking), 2018 Sep; 75(17): 3283-3296.
Impact Factor: 6.721
Dettagli Esporta in BibTeX Esporta in EndNote
Buonanno M, Coppola M, Di Lelio I, Molisso D, Leone M, Pennacchio F, Langella E, Rao R, Monti SM
* Prosystemin, a prohormone that modulates plant defense barriers, is an intrinsically disordered protein (328 visite)
Protein Sci (ISSN: 1469-896xelectronic, 0961-8368linking), 2018 Mar; 27(3): 620-632.
Impact Factor: 2.937
Dettagli Esporta in BibTeX Esporta in EndNote
Pirone L, Ripoll-rozada J, Leone M, Ronca R, Lombardo F, Fiorentino G, Andersen JF, Pereira PJB, Arcà B, Pedone E
* Functional analyses yield detailedinsight into the mechanism of thrombin inhibition by the antihemostatic salivary protein cE5 from Anopheles gambiae (327 visite) (PDF 180 visite)
Jbc Papers (ISSN: 0021-9258linking, 1083-351x), 2017 Jul 28; 292(30): 12632-12642.
Impact Factor: 4.125
Dettagli Esporta in BibTeX Esporta in EndNote
Vincenzi M, Costantini S, Scala S, Tesauro D, Accardo A, Leone M, Colonna G, Guillon J, Portella L, Trotta AM, Ronga L, Rossi F
* Conformational ensembles explored dynamically from disordered peptides targeting chemokine receptor CXCR4 (503 visite)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2015; 16(6): 12159-12173.
Impact Factor: 3.257
Dettagli Esporta in BibTeX Esporta in EndNote
Diana D, Smaldone G, De Antonellis P, Pirone L, Carotenuto M, Alonzi A, Di Gaetano S, Zollo M, Pedone E, Fattorusso R
* Mapping Functional Interaction Sites of Human Prune C-Terminal Domain by NMR Spectroscopy in Human Cell Lysates (322 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2013 Sep 9; 19(37): 12217-12220.
Impact Factor: 5.696
Dettagli Esporta in BibTeX Esporta in EndNote
Smaldone G, Falanga A, Capasso D, Guarnieri D, Correale S, Galdiero M, Netti PA, Zollo M, Galdiero S, Di Gaetano S, Pedone E
* gH625 is a viral derived peptide for effective delivery of intrinsically disordered proteins (407 visite)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1178-2013electronic), 2013; 8: 2555-2565.
Impact Factor: 4.195
Dettagli Esporta in BibTeX Esporta in EndNote
Accardo A, Leone M, Tesauro D, Aufiero R, Bénarouche A, Cavalier JF, Longhi S, Carriere F, Rossi F
* Solution conformational features and interfacial properties of an intrinsically disordered peptide coupled to alkyl chains: A new class of peptide amphiphiles (389 visite)
Mol Biosyst (ISSN: 1742-206x), 2013; 9(6): 1401-1410.
Impact Factor: 3.183
Dettagli Esporta in BibTeX Esporta in EndNote
Di Maro A, Berisio R, Ruggiero A, Tamburino R, Severino V, Zacchia E, Parente A
* Structural and enzymatic properties of an in vivo proteolytic form of PD-S2, type 1 ribosome-inactivating protein from seeds of Phytolacca dioica (332 visite)
Biochem Biophys Res Commun (ISSN: 0006-291x), 2012 May 11; 421(3): 514-520.
Impact Factor: 2.406
Dettagli Esporta in BibTeX Esporta in EndNote
Ruggiero A, Chambery A, Di Maro A, Parente A, Berisio R
* Atomic Resolution (1. 1 Angstrom) Structure Of The Ribosome-Inactivating Protein Pd-L4 From Phytolacca Dioica L. Leaves (350 visite)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2008 Apr; 71(1): 8-15.
Impact Factor: 3.419
Dettagli Esporta in BibTeX Esporta in EndNote
14 Records (14 escludendo Abstract e Conferenze).
Impact factor totale: 58.86 (58.86 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 50.669 (50.669 escludendo Abstract e Conferenze).
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