Plant polypeptides as natural enhancers of biostimulation
Contact person: Simona Maria Monti, marmonti
unina.it
Actors: Martina Buonanno, martina.buonannocnr.it, Emma Langella, emma.langellacnr.it, Simona Maria Monti, marmontiunina.it,
Research areas: Small molecules and peptides/modified peptides for diagnostic, therapeutic and biotechnological applications, Macromolecules for biomedical and biotechnological applications,
Keywords: Prosystemin, Biotic And Abiotic Stress, Plant Defence, Food And Health, Intrinsically Disordered Protein
Contact person: Simona Maria Monti, marmonti
unina.itActors: Martina Buonanno, martina.buonanno
cnr.it, Emma Langella, emma.langellacnr.it, Simona Maria Monti, marmontiunina.it, Description:
Plants cannot escape adverse environmental changes and have developed very efficient defense responses against stress agents. The molecular mechanisms underlying defense responses against insect attack are activated locally, at the damaged site, and promote a long-distance signaling largely modulated by jasmonic acid. Wound damage results both in local and systemic expression of proteinase inhibitors(PIs), disrupting the digestion of feeding insects. In tomato, these events are triggered by a peptide hormone named Systemin. The signaling molecule is an octadeca peptide intensely investigated over the years which, upon wounding, is released from the C-terminal region of a larger pro-hormone of 200 amino acids called Prosystemin (Prosys). Prosys gene is transcribed at low level in physiological conditions, while its expression is enhanced by mechanical wounding or feeding by herbivore insects. The observation that Prosys elicits multiple defense pathways to protect tomato plants against a wide range of stress agent suggested that it could play a role in plant defense broader than expected. Bymeans of biochemical and in silico studies we performed a structural and biochemical characterization of Prosys which provedthat it is a member of the Intrinsically Disordered Proteins (IDPs) family.IDPs are a class of proteins completely or only partially unstructured but still functionally active. These results, which contribute to increase theunderstanding of the multiple roles of Prosys in the defense mechanisms, pavethe way for innovative crop protection for sustainable agriculture with beneficial effects on human health.
Plants cannot escape adverse environmental changes and have developed very efficient defense responses against stress agents. The molecular mechanisms underlying defense responses against insect attack are activated locally, at the damaged site, and promote a long-distance signaling largely modulated by jasmonic acid. Wound damage results both in local and systemic expression of proteinase inhibitors(PIs), disrupting the digestion of feeding insects. In tomato, these events are triggered by a peptide hormone named Systemin. The signaling molecule is an octadeca peptide intensely investigated over the years which, upon wounding, is released from the C-terminal region of a larger pro-hormone of 200 amino acids called Prosystemin (Prosys). Prosys gene is transcribed at low level in physiological conditions, while its expression is enhanced by mechanical wounding or feeding by herbivore insects. The observation that Prosys elicits multiple defense pathways to protect tomato plants against a wide range of stress agent suggested that it could play a role in plant defense broader than expected. Bymeans of biochemical and in silico studies we performed a structural and biochemical characterization of Prosys which provedthat it is a member of the Intrinsically Disordered Proteins (IDPs) family.IDPs are a class of proteins completely or only partially unstructured but still functionally active. These results, which contribute to increase theunderstanding of the multiple roles of Prosys in the defense mechanisms, pavethe way for innovative crop protection for sustainable agriculture with beneficial effects on human health.
Selected papers:
Prosystemin, a prohormone that modulates plant defensebarriers, is an intrinsically disordered protein.
Protein Sci. 2018Mar;27(3):620-632.
Plant polypeptides as natural enhancers of biostimulation
Plant polypeptides as natural enhancers of biostimulation
Search related bibliography on PubMed
Search related bibliography on PubMed
Monti SM, De Simone G, Langella E
* The Amazing World of IDPs in Human Diseases II (5 views)
Biomolecules, 2022 Feb 25; 1211(2): 369-369.
Impact Factor: 6.064
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Langella E, Buonanno M, De Simone G, Monti SM
* Intrinsically disordered features of carbonic anhydrase IX proteoglycan-like domain (24 views)
Cell Mol Life Sci (ISSN: 1420-682xlinking), 2021 Mar; 78(5): 2059-2067.
Impact Factor: 9.261
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Monti SM, De Simone G, Langella E
* The Amazing World of IDPs in Human Diseases (26 views)
Biomolecules (ISSN: 2218-273xlinking), 2021 Feb 23; 11(2): 333-333.
Impact Factor: 4.879
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La Rosa C, Condorelli M, Compagnini G, Lolicato F, Milardi D, Do TN, Karttunen M, Pannuzzo M, Ramamoorthy A, Fraternali F, Collu F, Rezaei H, Strodel B, Raudino A
* Symmetry-breaking transitions in the early steps of protein self-assembly (69 views)
Eur Biophys J (ISSN: 0175-7571linking, 1432-1017), 2020 Mar; 49(2): 175-191.
Impact Factor: 2.094
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Vincenzi M, Mercurio FA, Leone M
* About TFE: Old and New Findings (86 views)
Curr Protein Pept Sci (ISSN: 1389-2037linking), 2019; 20 (5 ): 425-451.
Impact Factor: 3.011
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Scollo F, Tempra C, Lolicato F, Sciacca MFM, Raudino A, Milardi D, La Rosa C
* Phospholipids Critical Micellar Concentrations Trigger Different Mechanisms of Intrinsically Disordered Proteins Interaction with Model Membranes (362 views) (PDF 115 views)
J Phys Chem Lett (ISSN: 1948-7185electronic, 1948-7185linking), 2018 Sep 6; 9(17): 5125-5129.
Impact Factor: 6.687
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Langella E, Buonanno M, Vullo D, Dathan N, Leone M, Supuran C, De Simone G, Monti SM
* Biochemical, biophysical and molecular dynamics studies on the proteoglycan-like domain of carbonic anhydrase IX (299 views)
Cell Mol Life Sci (ISSN: 1420-682xlinking), 2018 Sep; 75(17): 3283-3296.
Impact Factor: 6.721
View Export to BibTeX Export to EndNote
Buonanno M, Coppola M, Di Lelio I, Molisso D, Leone M, Pennacchio F, Langella E, Rao R, Monti SM
* Prosystemin, a prohormone that modulates plant defense barriers, is an intrinsically disordered protein (331 views)
Protein Sci (ISSN: 1469-896xelectronic, 0961-8368linking), 2018 Mar; 27(3): 620-632.
Impact Factor: 2.937
View Export to BibTeX Export to EndNote
Pirone L, Ripoll-rozada J, Leone M, Ronca R, Lombardo F, Fiorentino G, Andersen JF, Pereira PJB, Arcà B, Pedone E
* Functional analyses yield detailedinsight into the mechanism of thrombin inhibition by the antihemostatic salivary protein cE5 from Anopheles gambiae (344 views) (PDF 188 views)
Jbc Papers (ISSN: 0021-9258linking, 1083-351x), 2017 Jul 28; 292(30): 12632-12642.
Impact Factor: 4.125
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Vincenzi M, Costantini S, Scala S, Tesauro D, Accardo A, Leone M, Colonna G, Guillon J, Portella L, Trotta AM, Ronga L, Rossi F
* Conformational ensembles explored dynamically from disordered peptides targeting chemokine receptor CXCR4 (508 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2015; 16(6): 12159-12173.
Impact Factor: 3.257
View Export to BibTeX Export to EndNote
Diana D, Smaldone G, De Antonellis P, Pirone L, Carotenuto M, Alonzi A, Di Gaetano S, Zollo M, Pedone E, Fattorusso R
* Mapping Functional Interaction Sites of Human Prune C-Terminal Domain by NMR Spectroscopy in Human Cell Lysates (339 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2013 Sep 9; 19(37): 12217-12220.
Impact Factor: 5.696
View Export to BibTeX Export to EndNote
Smaldone G, Falanga A, Capasso D, Guarnieri D, Correale S, Galdiero M, Netti PA, Zollo M, Galdiero S, Di Gaetano S, Pedone E
* gH625 is a viral derived peptide for effective delivery of intrinsically disordered proteins (414 views)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1178-2013electronic), 2013; 8: 2555-2565.
Impact Factor: 4.195
View Export to BibTeX Export to EndNote
Accardo A, Leone M, Tesauro D, Aufiero R, Bénarouche A, Cavalier JF, Longhi S, Carriere F, Rossi F
* Solution conformational features and interfacial properties of an intrinsically disordered peptide coupled to alkyl chains: A new class of peptide amphiphiles (395 views)
Mol Biosyst (ISSN: 1742-206x), 2013; 9(6): 1401-1410.
Impact Factor: 3.183
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Di Maro A, Berisio R, Ruggiero A, Tamburino R, Severino V, Zacchia E, Parente A
* Structural and enzymatic properties of an in vivo proteolytic form of PD-S2, type 1 ribosome-inactivating protein from seeds of Phytolacca dioica (343 views)
Biochem Biophys Res Commun (ISSN: 0006-291x), 2012 May 11; 421(3): 514-520.
Impact Factor: 2.406
View Export to BibTeX Export to EndNote
Ruggiero A, Chambery A, Di Maro A, Parente A, Berisio R
* Atomic Resolution (1. 1 Angstrom) Structure Of The Ribosome-Inactivating Protein Pd-L4 From Phytolacca Dioica L. Leaves (364 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2008 Apr; 71(1): 8-15.
Impact Factor: 3.419
View Export to BibTeX Export to EndNote
* The Amazing World of IDPs in Human Diseases II (5 views)
Biomolecules, 2022 Feb 25; 1211(2): 369-369.
Impact Factor: 6.064
View Export to BibTeX Export to EndNote
Langella E, Buonanno M, De Simone G, Monti SM
* Intrinsically disordered features of carbonic anhydrase IX proteoglycan-like domain (24 views)
Cell Mol Life Sci (ISSN: 1420-682xlinking), 2021 Mar; 78(5): 2059-2067.
Impact Factor: 9.261
View Export to BibTeX Export to EndNote
Monti SM, De Simone G, Langella E
* The Amazing World of IDPs in Human Diseases (26 views)
Biomolecules (ISSN: 2218-273xlinking), 2021 Feb 23; 11(2): 333-333.
Impact Factor: 4.879
View Export to BibTeX Export to EndNote
La Rosa C, Condorelli M, Compagnini G, Lolicato F, Milardi D, Do TN, Karttunen M, Pannuzzo M, Ramamoorthy A, Fraternali F, Collu F, Rezaei H, Strodel B, Raudino A
* Symmetry-breaking transitions in the early steps of protein self-assembly (69 views)
Eur Biophys J (ISSN: 0175-7571linking, 1432-1017), 2020 Mar; 49(2): 175-191.
Impact Factor: 2.094
View Export to BibTeX Export to EndNote
Vincenzi M, Mercurio FA, Leone M
* About TFE: Old and New Findings (86 views)
Curr Protein Pept Sci (ISSN: 1389-2037linking), 2019; 20 (5 ): 425-451.
Impact Factor: 3.011
View Export to BibTeX Export to EndNote
Scollo F, Tempra C, Lolicato F, Sciacca MFM, Raudino A, Milardi D, La Rosa C
* Phospholipids Critical Micellar Concentrations Trigger Different Mechanisms of Intrinsically Disordered Proteins Interaction with Model Membranes (362 views) (PDF 115 views)
J Phys Chem Lett (ISSN: 1948-7185electronic, 1948-7185linking), 2018 Sep 6; 9(17): 5125-5129.
Impact Factor: 6.687
View Export to BibTeX Export to EndNote
Langella E, Buonanno M, Vullo D, Dathan N, Leone M, Supuran C, De Simone G, Monti SM
* Biochemical, biophysical and molecular dynamics studies on the proteoglycan-like domain of carbonic anhydrase IX (299 views)
Cell Mol Life Sci (ISSN: 1420-682xlinking), 2018 Sep; 75(17): 3283-3296.
Impact Factor: 6.721
View Export to BibTeX Export to EndNote
Buonanno M, Coppola M, Di Lelio I, Molisso D, Leone M, Pennacchio F, Langella E, Rao R, Monti SM
* Prosystemin, a prohormone that modulates plant defense barriers, is an intrinsically disordered protein (331 views)
Protein Sci (ISSN: 1469-896xelectronic, 0961-8368linking), 2018 Mar; 27(3): 620-632.
Impact Factor: 2.937
View Export to BibTeX Export to EndNote
Pirone L, Ripoll-rozada J, Leone M, Ronca R, Lombardo F, Fiorentino G, Andersen JF, Pereira PJB, Arcà B, Pedone E
* Functional analyses yield detailedinsight into the mechanism of thrombin inhibition by the antihemostatic salivary protein cE5 from Anopheles gambiae (344 views) (PDF 188 views)
Jbc Papers (ISSN: 0021-9258linking, 1083-351x), 2017 Jul 28; 292(30): 12632-12642.
Impact Factor: 4.125
View Export to BibTeX Export to EndNote
Vincenzi M, Costantini S, Scala S, Tesauro D, Accardo A, Leone M, Colonna G, Guillon J, Portella L, Trotta AM, Ronga L, Rossi F
* Conformational ensembles explored dynamically from disordered peptides targeting chemokine receptor CXCR4 (508 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2015; 16(6): 12159-12173.
Impact Factor: 3.257
View Export to BibTeX Export to EndNote
Diana D, Smaldone G, De Antonellis P, Pirone L, Carotenuto M, Alonzi A, Di Gaetano S, Zollo M, Pedone E, Fattorusso R
* Mapping Functional Interaction Sites of Human Prune C-Terminal Domain by NMR Spectroscopy in Human Cell Lysates (339 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2013 Sep 9; 19(37): 12217-12220.
Impact Factor: 5.696
View Export to BibTeX Export to EndNote
Smaldone G, Falanga A, Capasso D, Guarnieri D, Correale S, Galdiero M, Netti PA, Zollo M, Galdiero S, Di Gaetano S, Pedone E
* gH625 is a viral derived peptide for effective delivery of intrinsically disordered proteins (414 views)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1178-2013electronic), 2013; 8: 2555-2565.
Impact Factor: 4.195
View Export to BibTeX Export to EndNote
Accardo A, Leone M, Tesauro D, Aufiero R, Bénarouche A, Cavalier JF, Longhi S, Carriere F, Rossi F
* Solution conformational features and interfacial properties of an intrinsically disordered peptide coupled to alkyl chains: A new class of peptide amphiphiles (395 views)
Mol Biosyst (ISSN: 1742-206x), 2013; 9(6): 1401-1410.
Impact Factor: 3.183
View Export to BibTeX Export to EndNote
Di Maro A, Berisio R, Ruggiero A, Tamburino R, Severino V, Zacchia E, Parente A
* Structural and enzymatic properties of an in vivo proteolytic form of PD-S2, type 1 ribosome-inactivating protein from seeds of Phytolacca dioica (343 views)
Biochem Biophys Res Commun (ISSN: 0006-291x), 2012 May 11; 421(3): 514-520.
Impact Factor: 2.406
View Export to BibTeX Export to EndNote
Ruggiero A, Chambery A, Di Maro A, Parente A, Berisio R
* Atomic Resolution (1. 1 Angstrom) Structure Of The Ribosome-Inactivating Protein Pd-L4 From Phytolacca Dioica L. Leaves (364 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2008 Apr; 71(1): 8-15.
Impact Factor: 3.419
View Export to BibTeX Export to EndNote
15 Records (15 excluding Abstracts).
Total impact factor: 67.935 (67.935 excluding Abstracts).
Total 5 year impact factor: 60.827 (60.827 excluding Abstracts).
Total impact factor: 67.935 (67.935 excluding Abstracts).
Total 5 year impact factor: 60.827 (60.827 excluding Abstracts).
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