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Segmentazione RM cerebrale basata sulla rilassometria
Responsabile: Marco Comerci, marco.comerciibb.cnr.it

Descrizione:
Sviluppo, messa a punto e sperimentazione di uno strumento software che calcola i rates (velocità) di rilassamento RM e densità protonica voxel per voxel (immagini QMCI), e segmenta la maggior parte dei tessuti del cervello, tra cui lesioni di sclerosi multipla.
La versione attuale, validata a 1 e 1. 5 Tesla, segmenta studi del cervello nei seguenti 18 compartimenti: Materia Grigia (GM); Sostanza bianca (WM); Demielinizzata / Bianca Anormale (AWM); Liquido Cerebrospinale (CSF); Globo Pallido; Putamen; Talamo; Nucleo Caudato; Sostanza Nigra; Nucleo Rosso; Nucleo Dentato; Muscolo, Grasso; Umor Vitreo; Tessuti Connettivi intra-cranici ed extra-cranici; Fluidi extra-cranici; e tessuti a bassa densità protonica. Il software produce informazioni volumetriche e rilassmetriche di ogni comparto.
Questa segmentazione basata su modello, utilizza velocità di rilassamento, densità protonica e informazioni anatomiche.
Il software è configurabile e può essere ottimizzato per varie situazioni ambientali, come diverse caratteristiche dello scanner e diverse regioni anatomiche (vedi anche Segmentazione RM arto basata sulla rilassometria).
Un modulo per la valutazione automatica di follow-up è stato inoltre sviluppato: allinea studi basali e di follow-up con coregistrazione rigida (basata sulla mutual information normalizzata del software SPM), taglia fuori i tessuti non comuni a tutti gli studi ed esegue l'analisi di Pearson su volumi e rates.
Applicazione per la ricerca neurologica: invecchiamento; Malattia di Alzheimer; Schizofrenia; malattie degenerative; correzione dell'effetto volume parziale per la PET e SPECT.
I miglioramenti attualmente in fase di test includono: segmentazione di studi cervello a 3T; correzione disomogeneità RM in ricezione e trasmissione (critico per studi 3T); Stima automatica del reale angolo di flip; registrazione di semi-serie disallineate. Registrazione affine di basale e dl follow-up per tener conto della deriva del gradiente MR; Miglioramento del modello anatomico e di segnale per gli studi del cervello.
I miglioramenti pianificati futuri sono: supporto fast spin Echo; supporto 3D FFE simil- T1w; Altre sequenze veloci 3D per le mappe rilassamento; Modello anatomico e di segnale ulteriormente migliorati per gli studi del cervello; segmentazione iterativa.

Aree di ricerca: Imaging Quantitativo

Attori:
Arturo Brunetti,
Mario Quarantelli, quaranteunina.it,
Anna Prinster, anna.prinsteribb.cnr.it,
Bruno Alfano,
Marco Comerci, marco.comerciibb.cnr.it,


Immagine QMCI e corrispondente immagine segmentata

Non disponibili.
A multiparametric and multiscale approach to automated segmentation of brain veins (accesso riservato) (135 views)
An MRI digital brain phantom for validation of segmentation methods (accesso riservato) (457 views)
An Ontology-Based Technique for Validation of MRI Brain Segmentation Methods (accesso riservato) (121 views)
Assessment of an automated vein segmentation algorithm for MRI brain acquisitions at different field strengths (dominio pubblico) (87 views)
Automated Segmentation and Measurement of Global White Matter Lesion Volume in Patients With Multiple Sclerosis (accesso riservato) (448 views)
Automated segmentation of multispectral brain MR images (accesso riservato) (104 views)
Automatic Segmentation of the Brain and Intracranial Cerebrospinal Fluid in T1-Weighted Volume MRI Scans of the Head, and Its Application to Serial Cerebral and Intracranial Volumetry (dominio pubblico) (105 views)
Fully automatic segmentation of white matter hyperintensities in MR images of the elderly (accesso riservato) (98 views)
Histogram-Based Characterization of Healthy and Ischemic Brain Tissues Using Multiparametric MR Imaging Including Apparent Diffusion Coefficient Maps and Relaxometry (dominio pubblico) (110 views)
Liver and Spleen Volumetry with Quantitative MR Imaging and Dual-Space Clustering Segmentation (dominio pubblico) (98 views)
Measurement of Global Brain Atrophy in Alzheimer’s Disease With Unsupervised Segmentation of Spin-Echo MRI Studies (accesso riservato) (148 views)
Multi-parametric algorithm for the automated segmentation of brain vein (dominio pubblico) (92 views)
Novel whole brain segmentation and volume estimation using quantitative MRI (accesso riservato) (117 views)
Probabilistic segmentation of brain tissue in MR imaging (accesso riservato) (98 views)
Probabilistic segmentation of white matter lesions in MR imaging (accesso riservato) (97 views)
Reproducibility of Intracranial Volume Measurement by Unsupervised Multispectral Brain Segmentation (accesso riservato) (425 views)
Segmentation of magnetic resonance brain images through discriminant analysis (accesso riservato) (120 views)
Semiautomatic Regional Segmentation to Measure Orbital Fat Volumes in Thyroid-Associated Ophthalmopathy A Validation Study (accesso riservato) (138 views)
Unified segmentation based correction of R1 brain maps for RF transmit field inhomogeneities (UNICORT) (accesso riservato) (109 views)
Unsupervised, Automated Segmentation of the Normal Brain Using a Multispectral Relaxometric Magnetic Resonance Approach (accesso riservato) (451 views)
White matter lesion extension to automatic brain tissue segmentation on MRI (accesso riservato) (113 views)
Whole-brain atrophy in multiple sclerosis measured by two segmentation processes from various MRI sequences (accesso riservato) (104 views)
[Cerca bibliografia correlata su PubMed]



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* . Early diagnosis of breast cancer by using Fast field cycling relaxometry (FFC-NMRD): investigations of ex-vivo murine breast tissue (25 visite)
Di Gregorio E, Ferrauto G, Lanzardo S, Gianolio E, Aime S
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Evidence for the Role of Intracellular Water Lifetime as a Tumour Biomarker Obtained by In Vivo Field-Cycling Relaxometry (22 visite)
Ruggiero MR, Baroni S, Pezzana S, Ferrante G, Geninatti Crich S, Aime S
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* Brain Susceptibility Changes in a Patient with Natalizumab-Related Progressive Multifocal Leukoencephalopathy: A Longitudinal Quantitative Susceptibility Mapping and Relaxometry Study (49 visite)
Pontillo G, Cocozza S, Lanzillo R, Borrelli P, De Rosa A, Brescia Morra V, Tedeschi E, Palma G
Front Neurol (ISSN: 1664-2295print, 1664-2295linking), 2017 Jun 19; 8: 294-294.
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* Assessment of an automated vein segmentation algorithm for MRI brain acquisitions at different field strengths (120 visite) (PDF 87 visite)
Monti S, Borrelli P, Cocozza S, Straub S, Ladd ME, Salvatore M, Mancini M, Tedeschi E, Palma G
6th Annual Meeting Of The International Society For Neurovascular Disease, 2016 Apr; N/D: N/D-N/D.
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Multi-parametric algorithm for the automated segmentation of brain vein (123 visite) (PDF 92 visite)
Monti S, Borrelli P, Cocozza S, Salvatore M, Mancini M, Tedeschi E, Palma G
6th Annual Meeting Of The International Society For Neurovascular Disease, 2016 Apr; N/D: N/D-N/D.
Dettagli    Esporta in BibTeX    Esporta in EndNote

* In vivo dentate nucleus MRI relaxometry correlates with previous administration of Gadolinium-based contrast agents (87 visite)
Tedeschi E, Palma G, Canna A, Cocozza S, Russo C, Borrelli P, Lanzillo R, Angelini V, Postiglione E, Morra VB, Salvatore M, Brunetti A, Quarantelli M
Eur Radiol (ISSN: 1432-1084electronic, 0938-7994linking), 2016 Feb 23; N/D: 1-8.
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* A multiparametric and multiscale approach to automated segmentation of brain veins (132 visite) (PDF 135 visite)
Monti S, Palma G, Borrelli P, Tedeschi E, Cocozza S, Salvatore M, Mancini M
Proceedings Of Engineering In Medicine And Biology Society, 2015; N/D: 3041-3044.
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* Does Gadolinium Change the Relaxometry of the Dentate Nuclei? A Quantitative Multi-parametric MRI Study (94 visite)
Tedeschi E, Russo C, Cocozza S, Palma G, Canna A, Borrelli P, Lanzillo R, Angelini V, Postiglione E, Brescia Morra V, Brunetti A, Salvatore M
Rsna 101st Scientific Assembly And Annual Meeting, 2015; N/D: N/D-N/D.
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* MULTIPARAMETRIC AUTOMATED SEGMENTATION OF BRAIN VEINS (160 visite)
Monti S, Palma G, Tedeschi E, Borrelli P, Cocozza S, Salvatore M, Mancini M
Veins And Lymphatics (ISSN: 2279-7483), 2015; 4(s1): 13-13.
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* Self-Trained Supervised Segmentation of Subcortical Brain Structures Using Multispectral Magnetic Resonance Images (160 visite)
Larobina M, Murino L, Cervo A, Alfano B
Biomed Research International, 2015; 2015: N/D-9.
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* Semiautomatic regional segmentation to measure orbital fat volumes in thyroid-associated ophthalmopathy. A validation study (186 visite) (PDF 138 visite)
Comerci M, Elefante A, Strianese D, Senese R, Bonavolonta P, Alfano B, Bonavolonta B, Brunetti A
Neuroradiol J (ISSN: 1971-4009, 1971-4009print, 1971-4009linking), 2013 Aug; 26(4): 373-379.
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* An MRI digital brain phantom for validation of segmentation methods (173 visite) (PDF 457 visite)
Alfano B, Comerci M, Larobina M, Prinster A, Hornak JP, Selvan SE, Amato U, Quarantelli M, Tedeschi G, Brunetti A, Salvatore M
Med Image Anal (ISSN: 1361-8415, 1361-8423, 1361-8415linking), 2011 Jun; 15(3): 329-339.
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* An ontology-based technique for validation of MRI brain segmentation methods (161 visite) (PDF 121 visite)
Alfano B, Comerci M, De Pietro G, Esposito A
Lecture Notes In Computer Science (ISSN: 0302-9743, 0302-974335404636319783540463634, 0302-974335402975459783540297543), 2007; 4805LNCS(PART1): 566-575.
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* Automated brain MR segmentation in a large MS population (148 visite)
Tedeschi G, Dinacci D, Lavorgna L, Bonavita V, Livrea P, Quattrone A, Messina C, Savettieri G, Paciello M, Reggio A, Brunetti A, Russo P, Alfano B
Neurology (ISSN: 0028-3878, 1526-632x), 2004 Apr 13; 62(7): N/D-N/D.
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* Segmentation of magnetic resonance brain images through discriminant analysis (215 visite) (PDF 120 visite)
Amato U, Larobina M, Antoniadis A, Alfano B
J Neurosci Methods (ISSN: 0165-0270), 2003 Dec 30; 131(1-2): 65-74.
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Automated segmentation and measurement of global white matter lesion volume in patients with multiple sclerosis (181 visite) (PDF 448 visite)
Alfano B, Brunetti A, Larobina M, Quarantelli M, Tedeschi E, Ciarmiello A, Covelli EM, Salvatore M
Journal Of Magnetic Resonance Imaging (ISSN: 1053-1807), 2000 Dec; 12(6): 799-807.
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Measurement of global brain atrophy in Alzheimer's disease with unsupervised segmentation of spin-echo MRI studies (170 visite) (PDF 148 visite)
Brunetti A, Postiglione A, Tedeschi E, Ciarmiello A, Quarantelli M, Covelli EM, Milan G, Larobina M, Soricelli A, Sodano A, Alfano B
Journal Of Magnetic Resonance Imaging (ISSN: 1053-1807), 2000 Mar; 11(3): 260-266.
Dettagli    Esporta in BibTeX    Esporta in EndNote

Measurement of global drain atrophy in Alzheimer's disease with unsupervised segmentation of spin-echo MRI studies (153 visite)
Brunetti A, Postiglione A, Tedeschi E, Ciarmiello A, Quarantelli M, Covelli E, Milan G, Larobina M, Soricelli A, Sodano A, Alfano B
Journal Of Magnetic Resonance Imaging (ISSN: 1053-1807), 2000 Mar; 11(3): N/D-N/D.
Dettagli    Esporta in BibTeX    Esporta in EndNote

Validation of an automated regional brain segmentation method using a stereotactic Talairach approach (137 visite)
Larobina M, Quarantelli M, Tedeschi E, Brunetti A, Alfano B, Salvatore M
Surgeryinternational Congress Series Car 97 Computer Assisted Radiology And (ISSN: 0531-5131), 1999; 1191: N/D-N/D.
Dettagli    Esporta in BibTeX    Esporta in EndNote

Reproducibility of intracranial volume measurement by unsupervised multispectral brain segmentation (171 visite) (PDF 425 visite)
Alfano B, Quarantelli M, Brunetti A, Larobina M, Covelli EM, Tedeschi E, Salvatore M
Magn Reson Med (ISSN: 0740-3194, 1522-2594electronic), 1998 Mar; 39(3): 497-499.
Dettagli    Esporta in BibTeX    Esporta in EndNote

Unsupervised, automated segmentation of the normal brain using a multispectral relaxometric magnetic resonance approach (198 visite) (PDF 451 visite)
Alfano B, Brunetti A, Covelli EM, Quarantelli M, Panico M, Ciarmiello A, Salvatore M
Magn Reson Med (ISSN: 0740-3194, 1522-2594electronic, 0740-3194linking), 1997 Jan; 37(1): 84-93.
Dettagli    Esporta in BibTeX    Esporta in EndNote

Fully-automated multispectral MR brain segmentation for detection and volumetric measurement of white matter lesions (141 visite)
Alfano B, Brunetti A, Quarantelli M, Larobina M, Covelli EM, Tedeschi E, Ciarmiello A, Salvatore M
Surgeryinternational Congress Series Car 97 Computer Assisted Radiology And (ISSN: 0531-5131), 1997; 1134: N/D-N/D.
Dettagli    Esporta in BibTeX    Esporta in EndNote

Unsupervised multifeature MR segmentation for assessment of intracranial liquoral spaces: Comparison with conventional linear measures (142 visite)
Brunetti A, Covelli E, Tedeschi E, Quarantelli M, Soricelli A, Salvatore M, Alfano B
Surgeryinternational Congress Series Car 97 Computer Assisted Radiology And (ISSN: 0531-5131), 1996; 1124: N/D-N/D.
Dettagli    Esporta in BibTeX    Esporta in EndNote

Automatic segmentation and evaluation of the volume of gray matter, white matter and cerebrospinal fluid by MRI (143 visite)
ALFANO B, ARPAIA M, BRUNETTI A, COVELLI E, CASTELLI L, CARACO C, SORICELLI A, TEDESCHI E, SALVATORE M
Neuroradiology 1994, 1994; N/D: N/D-N/D.
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24 Records (14 escludendo Abstract e Conferenze).
Impact factor totale: 51.625 (39.734 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 45.814 (27.412 escludendo Abstract e Conferenze).

Interrogazione bibliografica effettuata: ([btitle] "segmentation" OR [btitle] "relaxometry" OR [btitle] "followup" OR [btitle] "Relaxometry" OR [btitle] "segmentation")






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