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Software development of digital MRI brain phantom
Contact person: Marco Comerci, marco.comerciibb.cnr.it


Description ▼
This activity comprises the development and tuning of a software tool that can produce digital MRI brain phantoms, which simulate relaxation rate distributions of real target studies.
Digital brain phantoms are needed to assess the performance of segmentation methods, providing a gold standard, against which compare the segmentation produced by the softwares.
The phantom is composed of 17 tissue compartment and an optional abnormal white matter compartment, simulating MS lesions.
The software has four head models, two normal volunteers and two MS models. Currently the software allow to manually specify the mean signal intensities of the compartments, orientation, position, noise and other parameters or derive them from a target study, segmented automatically by our segmentation software, optionally warping the phantom to the target study.
Four sample phantoms, one for each model, and the custom phantoms are available for download at this link.

Actors ▼
Marco Comerci, marco.comerciibb.cnr.it
Bruno Alfano,
Anna Prinster, anna.prinsteribb.cnr.it

Keywords ▼
Mri, segmentation, relaxometry, phantom, quantitative magnetic color imaging, multiparametric,

Research Areas ▼
Quantitative Imaging

Figures ▼

Physical model: R1 and compartments


Selected Papers ▼
QMCI:Alfano BBrunetti A, Arpaia M, Ciarmiello A, Covelli EM, Salvatore M, J Magn Reson Imaging, 1995 Mar-Apr;5 (2):217-225Alfano BBrunetti A, Ciarmiello A, Salvatore M, J Comput Assist Tomogr, 1992 Jul-Aug;16 (4):634-640

Segmentation:
Alfano BBrunetti ALarobina MQuarantelli MTedeschi E, Ciarmiello A, Covelli EM, Salvatore M, J Magn Reson Imaging, 2000 Dec;12 (6):799-807Alfano BQuarantelli MBrunetti ALarobina M, Covelli EM, Tedeschi ESalvatore M, Magn Reson Med, 1998 Mar;39 (3):497-499Alfano BBrunetti A, Covelli EM, Quarantelli MPanico M, Ciarmiello A, Salvatore M, Magn Reson Med, 1997 Jan;37 (1):84-93

Phantom:
Alfano BComerci MLarobina MPrinster A, Hornak JP, Selvan SE, Amato U, Quarantelli M, Tedeschi G, Brunetti ASalvatore M, Med Image Anal, 2011 Jun;15 (3):329-339

Related Activities ▼
Relaxometry based MRI brain segmentation (3470 views)
Relaxometry based MRI limb segmentation (1894 views)

Related Papers ▼
Assessment of scanner performance and normalization of estimated relaxation rate values (restricted access) (88 views)
Novel whole brain segmentation and volume estimation using quantitative MRI (restricted access) (88 views)

Related bibliography▼
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* Highly efficient DNA-free gene disruption in the agricultural pest Ceratitis capitata by CRISPR-Cas9 ribonucleoprotein complexes (25 views)
Meccariello A, Monti SM, Romanelli A, Colonna R, Primo P, Inghilterra MG, Del Corsano G, Ramaglia A, Iazzetti G, Chiarore A, Patti F, Heinze SD, Salvemini M, Lindsay H, Chiavacci E, Burger A, Robinson MD, Mosimann C, Bopp D, Saccone G
Sci Rep (ISSN: 2045-2322electronic, 2045-2322linking), 2017 Aug 30; 7(1): 10061-10061.

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* Grey: white matter ratio at diagnosis and the risk of 10-year multiple sclerosis progression (59 views)
Moccia M, Quarantelli M, Lanzillo R, Cocozza S, Carotenuto A, Carotenuto B, Alfano B, Prinster A, Triassi M, Nardone A, Palladino R, Brunetti A, Brescia Morra V
Eur J Neurol (ISSN: 1468-1331electronic, 1351-5101linking), 2017 Jan; 24(1): 195-204.

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* Assessment of an automated vein segmentation algorithm for MRI brain acquisitions at different field strengths (85 views) (PDF 58 views)
Monti S, Borrelli P, Cocozza S, Straub S, Ladd ME, Salvatore M, Mancini M, Tedeschi E, Palma G
6th Annual Meeting Of The International Society For Neurovascular Disease, 2016 Apr; N/D: N/D-N/D.

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* Multi-parametric algorithm for the automated segmentation of brain vein (86 views) (PDF 66 views)
Monti S, Borrelli P, Cocozza S, Salvatore M, Mancini M, Tedeschi E, Palma G
6th Annual Meeting Of The International Society For Neurovascular Disease, 2016 Apr; N/D: N/D-N/D.

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* Cerebral Involvement in Stargardt's Disease: A VBM and TBSS Study (93 views)
Gaia O, Melillo P, Sirio C, D'Alterio FM, Prinster A, Testa F, Brunetti A, Simonelli F, Quarantelli M
Invest Ophthalmol Vis Sci (ISSN: 1552-5783electronic, 0146-0404linking), 2015 Nov; 56(12): 7388-7397.

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* A multiparametric and multiscale approach to automated segmentation of brain veins (102 views) (PDF 102 views)
Monti S, Palma G, Borrelli P, Tedeschi E, Cocozza S, Salvatore M, Mancini M
Proceedings Of Engineering In Medicine And Biology Society, 2015; N/D: 3041-3044.

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* MULTIPARAMETRIC AUTOMATED SEGMENTATION OF BRAIN VEINS (126 views)
Monti S, Palma G, Tedeschi E, Borrelli P, Cocozza S, Salvatore M, Mancini M
Veins And Lymphatics (ISSN: 2279-7483), 2015; 4(s1): 13-13.

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* Evaluation of supervised methods for the classification of major tissues and subcortical structures in multispectral brain magnetic resonance images (155 views) (PDF 97 views)
Murino L, Granata D, Carfora MF, Selvan SE, Alfano B, Amato U, Larobina M
Comput Med Imaging Graph Elsevier Ltd (ISSN: 0895-6111, 1879-0771), 2014 Jul; 38(5): 337-347.

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* Clinical And Magnetic Resonance Imaging Predictors Of Disease Progression In Multiple Sclerosis: A Nine-Year Follow-Up Study (136 views) (PDF 99 views)
Lavorgna L, Bonavita S, Ippolito D, Lanzillo R, Salemi G, Patti F, Valentino P, Coniglio G, Buccafusca M, Paolicelli D, D'Ambrosio A, Bresciamorra V, Savettieri G, Zappia M, Alfano B, Gallo A, Simone I, Tedeschi G
Mult Scler (ISSN: 1352-4585, 1352-2458, 1477-0970), 2014 Feb; 20(2): 220-226.

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* Semiautomatic regional segmentation to measure orbital fat volumes in thyroid-associated ophthalmopathy. A validation study (137 views) (PDF 113 views)
Comerci M, Elefante A, Strianese D, Senese R, Bonavolonta P, Alfano B, Bonavolonta B, Brunetti A
Neuroradiol J (ISSN: 1971-4009, 1971-4009print, 1971-4009linking), 2013 Aug; 26(4): 373-379.

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* An MRI digital brain phantom for validation of segmentation methods (135 views) (PDF 350 views)
Alfano B, Comerci M, Larobina M, Prinster A, Hornak JP, Selvan SE, Amato U, Quarantelli M, Tedeschi G, Brunetti A, Salvatore M
Med Image Anal (ISSN: 1361-8415, 1361-8423, 1361-8415linking), 2011 Jun; 15(3): 329-339.

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* A Computer Vision Approach to Micro-Nucleus automatic detection and surface measurements (131 views)
Ceccarelli M, Speranza A, Grimaldi D, Lamonaca F
Vols 1 3i2mtc, 2010 Sep 10; 59(9): 2383-2390.

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* Correlation between fatigue and brain atrophy and lesion load in multiple sclerosis patients independent of disability (122 views) (PDF 90 views)
Tedeschi G, Dinacci D, Lavorgna L, Prinster A, Savettieri G, Quattrone A, Livrea P, Messina C, Reggio A, Servillo G, Bresciamorra V, Orefice G, Paciello M, Brunetti A, Paolillo A, Coniglio G, Bonavita S, Di Costanzo A, Bellacosa A, Valentino P, Quarantelli M, Patti F, Salemi G, Cammarata E, Simone I, Salvatore M, Bonavita V, Alfano B
J Neurol Sci (ISSN: 0022-510x), 2007 Dec 15; 263(1-2): 15-19.

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* An ontology approach for classification of abnormal white matter in patients with Multiple Sclerosis (126 views) (PDF 113 views)
Alfano B, Brunetti A, De Pietro G, Esposito A
Lecture Notes In Computer Science (ISSN: 0302-9743, 0302-974335404636319783540463634, 0302-974335402975459783540297543), 2007; 4799LNCS: 389-402.

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* An ontology-based technique for validation of MRI brain segmentation methods (128 views) (PDF 95 views)
Alfano B, Comerci M, De Pietro G, Esposito A
Lecture Notes In Computer Science (ISSN: 0302-9743, 0302-974335404636319783540463634, 0302-974335402975459783540297543), 2007; 4805LNCS(PART1): 566-575.

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* Modifications of brain tissue volumes in facioscapulohumeral dystrophy (153 views)
Quarantelli M, Lanzillo R, Del Vecchio W, Mollica C, Prinster A, Iadicicco L, Iodice V, Santoro L, Salvatore M
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2006 Sep; 32(3): 1237-1242.

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* Mapping The Relative Contribution Of Gray Matter Activity Versus Volume In Brain Pet. A New Approach (118 views) (PDF 93 views)
Berkouk K, Quarantelli M, Prinster A, Landeau B, Alfano B, Baron JC
J Neuroimaging (ISSN: 1051-2284), 2006 Jul; 16(3): 224-235.

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* Brain atrophy and lesion load in a large population of patients with multiple sclerosis (125 views) (PDF 114 views)
Tedeschi G, Lavorgna L, Russo P, Prinster A, Dinacci D, Savettieri G, Quattrone A, Livrea P, Messina C, Reggio A, Bresciamorra V, Orefice G, Paciello M, Brunetti A, Coniglio G, Bonavita S, Di Costanzo A, Bellacosa A, Valentino P, Quarantelli M, Patti F, Salemi G, Cammarata E, Simone IL, Salvatore M, Bonavita V, Alfano B
Neurology (ISSN: 0028-3878, 1526-632x), 2005 Jul 26; 65(2): 280-285.

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* Automated brain MR segmentation in a large MS population (117 views)
Tedeschi G, Dinacci D, Lavorgna L, Bonavita V, Livrea P, Quattrone A, Messina C, Savettieri G, Paciello M, Reggio A, Brunetti A, Russo P, Alfano B
Neurology (ISSN: 0028-3878, 1526-632x), 2004 Apr 13; 62(7): N/D-N/D.

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* Integrated software for the analysis of brain PET/SPECT studies with partial-volume-effect correction (120 views) (PDF 92 views)
Quarantelli M, Berkouk K, Prinster A, Landeau B, Svarer C, Balkay L, Alfano B, Brunetti A, Baron JC, Salvatore M
Journal Of Nuclear Medicine (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2004 Feb; 45(2): 192-201.

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* Segmentation of magnetic resonance brain images through discriminant analysis (173 views) (PDF 89 views)
Amato U, Larobina M, Antoniadis A, Alfano B
J Neurosci Methods (ISSN: 0165-0270), 2003 Dec 30; 131(1-2): 65-74.

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* Brain tissue volume changes in relapsing-remitting multiple sclerosis: Correlation with lesion load (135 views) (PDF 87 views)
Quarantelli M, Ciarmiello A, Morra VB, Orefice G, Larobina M, Lanzillo R, Schiavone V, Salvatore E, Alfano B, Brunetti A
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2003 Feb; 18(2): 360-366.

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* Ex vivo assessment of trabecular bone structure from three-dimensional projection reconstruction MR micro-images (126 views)
Accardo A, Candido G, Jellù V, Toffanin R, Vittur F
Ieee Trans Biomed Eng (ISSN: 0018-9294), 2003; 50(8): 967-977.

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Measurement of global brain atrophy in Alzheimer's disease with unsupervised segmentation of spin-echo MRI studies (129 views) (PDF 122 views)
Brunetti A, Postiglione A, Tedeschi E, Ciarmiello A, Quarantelli M, Covelli EM, Milan G, Larobina M, Soricelli A, Sodano A, Alfano B
Journal Of Magnetic Resonance Imaging (ISSN: 1053-1807), 2000 Mar; 11(3): 260-266.

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Measurement of global drain atrophy in Alzheimer's disease with unsupervised segmentation of spin-echo MRI studies (109 views)
Brunetti A, Postiglione A, Tedeschi E, Ciarmiello A, Quarantelli M, Covelli E, Milan G, Larobina M, Soricelli A, Sodano A, Alfano B
Journal Of Magnetic Resonance Imaging (ISSN: 1053-1807), 2000 Mar; 11(3): N/D-N/D.

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Validation of an automated regional brain segmentation method using a stereotactic Talairach approach (106 views)
Larobina M, Quarantelli M, Tedeschi E, Brunetti A, Alfano B, Salvatore M
Surgeryinternational Congress Series Car 97 Computer Assisted Radiology And (ISSN: 0531-5131), 1999; 1191: N/D-N/D.

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Unsupervised, automated segmentation of the normal brain using a multispectral relaxometric magnetic resonance approach (159 views) (PDF 347 views)
Alfano B, Brunetti A, Covelli EM, Quarantelli M, Panico M, Ciarmiello A, Salvatore M
Magn Reson Med (ISSN: 0740-3194, 1522-2594electronic, 0740-3194linking), 1997 Jan; 37(1): 84-93.

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Fully-automated multispectral MR brain segmentation for detection and volumetric measurement of white matter lesions (107 views)
Alfano B, Brunetti A, Quarantelli M, Larobina M, Covelli EM, Tedeschi E, Ciarmiello A, Salvatore M
Surgeryinternational Congress Series Car 97 Computer Assisted Radiology And (ISSN: 0531-5131), 1997; 1134: N/D-N/D.

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Unsupervised multifeature MR segmentation for assessment of intracranial liquoral spaces: Comparison with conventional linear measures (107 views)
Brunetti A, Covelli E, Tedeschi E, Quarantelli M, Soricelli A, Salvatore M, Alfano B
Surgeryinternational Congress Series Car 97 Computer Assisted Radiology And (ISSN: 0531-5131), 1996; 1124: N/D-N/D.

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Automatic segmentation and evaluation of the volume of gray matter, white matter and cerebrospinal fluid by MRI (110 views)
ALFANO B, ARPAIA M, BRUNETTI A, COVELLI E, CASTELLI L, CARACO C, SORICELLI A, TEDESCHI E, SALVATORE M
Neuroradiology 1994, 1994; N/D: N/D-N/D.

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36 Records (26 excluding Abstracts and Conferences).
Total impact factor: 82.43 (70.539 excluding Abstracts and Conferences).
Total 5-year impact factor: 101.392 (82.99 excluding Abstracts and Conferences).



Your bibliography query: ([btitle, keywords, abstract] SEGMENTATION)



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