Figures Figure:

Figure 1. The crystal structure of the Sulfolobus solfataricus Thioredoxin reductase B3

Figure 2. The crystal structure of the transcription factor BldR from Sulfolobus solfataricus

Selected papers Lavori selezionati:
Contursi P, D'Ambrosio K, Pirone L, Pedone E, Aucelli T, She Q, De Simone G, Bartolucci S. Biochem J. 2011; 435: 157-66Vergara A, Vitagliano L, Merlino A, Sica F, Marino K, Verde C, di Prisco G, Mazzarella L. An order-disorder transition plays a role in switching off the root effect in fish hemoglobins. J Biol Chem. 2010, 285: 32568-75. Pedone E, Limauro D, D'Ambrosio K, De Simone G, Bartolucci S. Multiple catalytically active thioredoxin folds: a winning strategy for many functions. Cell Mol Life Sci. 2010 Nov; 67 (22): 3797-814. Limauro D, D'Ambrosio K, Langella E, De Simone G, Galdi I, Pedone C, Pedone E, Bartolucci S. Exploring the catalytic mechanism of the first dimeric Bcp: Functional, structural and docking analyses of Bcp4 from Sulfolobus solfataricus. Biochimie. 2010 Oct; 92 (10): 1435-44. Ruggiero A, Masullo M, Marasco D, Ruocco MR, Grimaldi P, Arcari P, Zagari A, Vitagliano L. The dimeric structure of Sulfolobus solfataricus thioredoxin A2 and the basis of its thermostability. Proteins. 2009. 77: 1004-8. Merlino A, Vitagliano L, Howes BD, Verde C, di Prisco G, Smulevich G, Sica F, Vergara A. Combined crystallographic and spectroscopic analysis of Trematomus bernacchii hemoglobin highlights analogies and differences in the peculiar oxidation pathway of Antarctic fish hemoglobins. Biopolymers. 2009 91: 1117-1125. Ruggiero A, Masullo M, Ruocco MR, Grimaldi P, Lanzotti MA, Arcari P, Zagari A, Vitagliano L. Structure and stability of a thioredoxin reductase from Sulfolobus solfataricus: A thermostable protein with two functions. Biochim Biophys Acta. 2009 1794: 554-62. Di Fiore A, Fiorentino G, Vitale RM, Ronca R, Amodeo P, Pedone C, Bartolucci S, De Simone G. J Mol Biol. 2009; 388: 559-69. Pennacchio A, Esposito L, Zagari A, Rossi M, Raia CA. Role of tryptophan 95 in substrate specificity and structural stability of Sulfolobus solfataricus alcohol dehydrogenase. Extremophiles. 2009 13: 751-61. Vitagliano L, Vergara A, Bonomi G, Merlino A, Verde C, di Prisco G, Howes BD, Smulevich G, Mazzarella L. Spectroscopic and crystallographic characterizationof a tetrameric hemoglobin oxidation pathway reveals structural features of a functional intermediate R/T state. J Am Chem Soc. 2008 130: 10527-35. Pedone E, D'Ambrosio K, De Simone G, Rossi M, Pedone C, Bartolucci S. Insights on a New PDI-like Family: Structural and Functional Analysis of a Protein Disulfide Oxidoreductase from the Bacterium Aquifex aeolicus. J Mol Biol. 356 (1): 155-64, 2006. De Simone G, Mandrich L, Menchise V, Giordano V, Febbraio F, Rossi M, Pedone C, Manco G. J Biol Chem. 2004; 279: 6815-23. Esposito L, Bruno I, Sica F, Raia CA, Giordano A, Rossi M, Mazzarella L, Zagari A. Crystal structure of a ternary complex of the alcohol dehydrogenase from Sulfolobus solfataricus. Biochemistry. 2003 42: 14397-407.