Description: Monoclonal Antibodies (MAbs) represent a class of molecules with high specificity and affinity for the target. MAbs can be raised against virtually any antigen, provided they are sufficiently immunogenic and sufficiently large to be recognized by the immune system. We are developing MAbs against several protein antigens which are recognized as biomarkers for several cancer as well as other important diseases. Among the others we have developed MAbs against Cripto and Nodal, two main players of the activin receptor complex signaling. They are largely overexpressed in several types of cancers and their detection in tissues and in biological fluids is of utmost importance for diagnostic and prognostic purposes. Furthermore, the screening of clones using specific mutated antigens, has allowed the selection of MAbs having neutralizing activity for their respective receptors
Monoclonal Antibodies for therapeutic and diagnostic applications
Testino G, Leone S, Fagoonee S, Del Bas JM, Rodriguez B, Puiggros F, Marine S, Rodriguez MA, Morina D, Armengol L, Caimari A, Arola L, Cimini FA, Barchetta I, Carotti S, Bertoccini L, Baroni MG, Vespasiani-gentilucci U, Cavallo MG, Morini S, Nelson JE, Roth CL, Wilson LA, Yates KP, Aouizerat B, Morgan-stevenson V, Whalen E, Hoofnagle A, Mason M, Gersuk V, Yeh MM, Kowdley KV, Lee SM, Jun DW, Cho YK, Jang KS, Kucukazman M, Ata N, Dal K, Yeniova AO, Kefeli A, Basyigit S, Aktas B, Akin KO, Agladioglu K, Ure OS, Topal F, Nazligul Y, Beyan E, Ertugrul DT, Catena C, Cosma C, Camozzi V, Plebani M, Ermani M, Sechi LA, Fallo F, Goto Y, Ray MB, Mendenhall CL, French SW, Gartside PS Serum vitamin A deficiency and increased intrahepatic expression of cytokeratin antigen in alcoholic liver disease(579 views) Hepatology (ISSN: 1827-1669electronic, 0026-4806linking), 1988 Sep; 83120693611123109(5): 1019-1026. Impact Factor:0.913 ViewExport to BibTeXExport to EndNote
52 Records (50 excluding Abstracts). Total impact factor: 175.759 (165.985 excluding Abstracts). Total 5 year impact factor: 158.435 (148.147 excluding Abstracts).