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Metals role in angiogenesis
Responsabile: Antonio Magrì, antonio.magricnr.it

The determination of the exact role (s) of copper ion in angiogenesis processes, can be an essential result to design new potential therapeutic agents for different severe pathologies. This requires the understanding of the metal interaction with different angiogenic factors, and its involvement in different pathways. The research activity is focused on the synthesis and the study of some peptide fragments related to Angiogenin, VEGF, HPRG proteins and fibronectin and metal/peptide complexes study. Angiogenin is a soluble protein present in normal blood plasma, able to bind till 2. 4 copper ions per molecule, and overexpressed in patients affected by different types of cancers. We have studied the copper (II) interaction with angiogenin (entire protein) and in order to gain a better understanding the metal coordination environment in the protein, different peptide fragments have been synthesized and their copper (II) complexes characterized. VEGF165 fragments, some of which including VEGF protein? 5-? 6 loop aminoacid region and containing the overlapping VEGF binding sites to VEGFR-2, has been opportunely chosen and synthesized. These sequences include some His and VEGF-VEGFR interaction sites. VEGF165, its fragments and their metals complexes are investigated by means of molecular study and biological assay. The most striking feature of Histidine-rich glycoprotein (HRG) is its unusually high content of histidine and proline residues which are concentrated in a specific domain containing multiple conserved tandem repeats of the pentapeptide GHHPH. In this context we have synthesized and characterized these complexes with different tandem-repeat fragments. A series of single-point-mutation peptides of PHSRN sequence, which is a fibronectin recognition site of integrins, are immobilized at support surfaces for attachment cell studies. Endothelial cells attachment and interaction with the extracellular matrix (ECM) transmits signal cascades that mediate major angiogenic responses. The goal of this part of the research is to develop strategies to produce bioactive and biodegradable scaffolds. The angiogenic potential of copper ions, both alone and in combination with these peptide sequences, is going to be investigated as biomaterial support

Antonio Magrì, antonio.magricnr.it,
Anna Maria Santoro, annamaria.santorocnr.it,
Giulia Grasso, giulia.grassoibb.cnr.it,

Parole chiave: Metals, angiogenic factors

Non disponibili.
J. Colloid Interface Sci. (2010) 341, 232-239-Dalton Trans., (2010) 10678-10684-Dalton Trans., (2010) 10678-10684
Nessun risultato.
[Cerca bibliografia correlata su PubMed]

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* Heme accumulation in endothelial cells impairs angiogenesis by triggering paraptosis (34 visite)
Petrillo S, Chiabrando D, Genova T, Fiorito V, Ingoglia G, Vinchi F, Mussano F, Carossa S, Silengo L, Altruda F, Merlo GR, Munaron L, Tolosano E
Cell Death Differ (ISSN: 1476-5403electronic, 1350-9047linking), 2017 Dec 11; N/D: N/D-N/D.
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* Nano-sized and other improved reporters for magnetic resonance imaging of angiogenesis (38 visite)
Crich SG, Terreno E, Aime S
Adv Drug Deliv Rev (ISSN: 1872-8294electronic, 0169-409xlinking), 2017 Sep 15; 119: 61-72.
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* Human IgG1 antibodies suppress angiogenesis in a target-independent manner (246 visite)
Bogdanovich S, Kim Y, Mizutani T, Yasuma R, Tudisco L, Cicatiello V, Bastos-carvalho A, Kerur N, Hirano Y, Baffi JZ, Tarallo V, Li S, Yasuma T, Arpitha P, Fowler BJ, Wright CB, Apicella I, Greco A, Brunetti A, Ruvo M, Sandomenico A, Nozaki M, Ijima R, Kaneko H, Ogura Y, Terasaki H, Ambati BK, Leusen JH, Langdon WY, Clark MR, Armour KL, Bruhns P, Verbeek JS, Gelfand BD, De Falco S, Ambati J
Signal Transduct Target Ther (ISSN: 2059-3635print), 2016; 1: N/D-N/D.
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* Peptides Interacting with Growth Factor Receptors Regulating Angiogenesis (51 visite)
Di Stasi R, De Rosa L, Romanelli A, D'Andrea LD
Frontiers In Medicinal Chemistry, 2016; 9: 130-160.
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* UPARANT: a urokinase receptor-derived peptide inhibitor of VEGF-driven angiogenesis with enhanced stability and in vitro and in vivo potency (119 visite)
Carriero MV, Bifulco K, Minopoli M, Lista L, Maglio O, Mele L, Di Carluccio G, De Rosa M, Pavone V
Mol Cancer Ther Molecular Cancer Therapeutics (ISSN: 1538-8514electronic, 1535-7163linking), 2014 May; 13(5): 1092-1104.
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* IL-32 Promotes Angiogenesis (185 visite)
Nold-Petry CA, Rudloff I, Baumer Y, Ruvo M, Marasco D, Botti P, Farkas L, Cho SX, Zepp JA, Azam T, Dinkel H, Palmer BE, Boisvert WA, Cool CD, Taraseviciene-Stewart L, Heinhuis B, Joosten LA, Dinarello CA, Voelkel NF, Nold MF
Journal Of Immunology (ISSN: 0022-1767), 2014 Jan 15; 192(2): 589-602.
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* Imaging of thyroid tumor angiogenesis with microbubbles targeted to vascular endothelial growth factor receptor type 2 in mice (214 visite)
Mancini M, Greco A, Salvatore G, Liuzzi R, Di Maro G, Vergara E, Chiappetta G, Pasquinelli R, Brunetti A, Salvatore M
Bmc Medical Imaging (ISSN: 1471-2342), 2013 Sep 12; 13: 31-31.
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* β2-adrenergic receptor stimulation improves endothelial progenitor cell-mediated ischemic neoangiogenesis (88 visite)
Galasso G, De Rosa R, Ciccarelli M, Sorriento D, Del Giudice C, Strisciuglio T, De Biase C, Luciano R, Piccolo R, Pierri A, Di Gioia G, Prevete N, Trimarco B, Piscione F, Iaccarino G
Circ Res (ISSN: 0009-7330, 1524-4571electronic, 0009-7330linking), 2013; 112(7): 1026-1034.
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* Functional and pharmacological characterization of a VEGF mimetic peptide on reparative angiogenesis (146 visite)
Finetti F, Basile A, Capasso D, Di Gaetano S, Di Stasi R, Pascale M, Turco CM, Ziche M, Morbidelli L, D'Andrea LD
Biochem Pharmacol Biochemical Pharmacology (ISSN: 0006-2952, 1873-2968), 2012 Sep 1; 84(3): 303-311.
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* Impaired neoangiogenesis in β2-adrenoceptor gene-deficient mice: Restoration by intravascular human β2-adrenoceptor gene transfer and role of NFkB and CREB transcription factors (97 visite)
Ciccarelli M, Sorriento D, Cipolletta E, Santulli G, Fusco A, Zhou R-H, Eckhart AD, Peppel K, Koch WJ, Trimarco B, Iaccarino G
Br J Pharmacol British Journal Of Pharmacology (ISSN: 0007-1188), 2011; 162(3): 712-721.
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* Bioinorganic aspects of angiogenesis (105 visite)
D'Andrea LD, Romanelli A, Di Stasi R, Pedone C
Dalton Trans (ISSN: 1477-9234, 1477-9226, 1477-9234electronic), 2010 Sep 7; 39(33): 7625-7636.
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* Peptides targeting angiogenesis related growth factor receptors (13849 visite)
D'Andrea LD, Del Gatto A, De Rosa L, Romanelli A, Pedone C
Curr Pharm Des Current Pharmaceutical Design (ISSN: 1873-4286, 1381-6128), 2009 Jul; 15(21): 2414-2429.
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* Modulation of Angiogenesis by a Tetrameric Tripeptide That Antagonizes Vascular Endothelial Growth Factor Receptor (99 visite)
Ponticelli S, Marasco D, Tarallo V, Albuquerque RJC, Mitola S, Takeda A, Stassen J, Presta M, Ambati J, Ruvo M, De Falco S
J Biol Chem Journal Of Biological Chemistry (ISSN: 0021-9258, 1083-351x), 2008 Dec 5; 283(49): 34250-34259.
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* Angiogenesis modulation: identification of tetrameric tripeptide as inhibitor of VEGFR-1 by the screening of peptide combinatiorial libraries (86 visite)
Ponticelli S, Takeda A, Mitola S, Stassen J, Presta M, Ambati J, Ruvo M, De Falco S, Marasco D
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
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* Vascular Endothelial Growth Factor (VEGF) and its receptors: key regulators of angiogenesis (78 visite)
Di Stasi R, Capasso D, Diana D, Fattorusso R, Pedone C, D'Andrea LD
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
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* Peptide-based molecules in angiogenesis (126 visite)
D'Andrea LD, Del Gatto A, Pedone C, Benedetti E
Chem Biol Drug Des Chemical Biology And Drug Design (ISSN: 1747-0277, 1747-0285), 2006 Feb; 67(2): 115-126.
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* Engineering Peptides In Angiogenesis (92 visite)
Del Gatto A, D'Andrea LD, Zaccaro L, Saviano M, Pedone C, Benedetti E
Biopolymers, 2006; 0: 215-216.
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* Targeting angiogenesis: Structural characterization and biological properties of a de novo engineered VEGF mimicking peptide (120 visite)
D'Andrea LD, Iaccarino G, Fattorusso R, Sorriento D, Carannante C, Capasso D, Trimarco B, Pedone C
Proc Natl Acad Sci U S A (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2005 Oct 4; 102(40): 14215-14220.
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* Ischemic neoangiogenesis enhanced by β2-adrenergic receptor overexpression: A novel role for the endothelial adrenergic system (97 visite)
Iaccarino G, Ciccarelli M, Sorriento D, Galasso G, Campanile A, Santulli G, Cipolletta E, Cerullo V, Cimini V, Altobelli GG, Piscione F, Priante O, Pastore L, Chiariello M, Salvatore F, Koch WJ, Trimarco B
Circ Res (ISSN: 0009-7330, 1524-4571electronic), 2005; 97(11): 1182-1189.
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19 Records (17 escludendo Abstract e Conferenze).
Impact factor totale: 82.035 (78.727 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 84.798 (81.234 escludendo Abstract e Conferenze).

Interrogazione bibliografica effettuata: ([btitle] "angiogenic factors" OR [btitle] "angiogenesis")

Ultima modifica di Marco Comerci in data Wednesday 26 March 2014, 9:29:57
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