Descrizione: My scientific interests include the organic synthesis of various compounds. These are benzodifurans, 2,2'-disubstituted 2-propanones, artificial amino acids, nucleoamino acids, fructosyl-amino acids.... Nevertheless, I am continuing my solid phase synthesis activity for the realization of various peptide-like molecules. Oligo-epsilon-lysines or more in general oligo-diamino acids, nucleobase-bearing peptides are only some examples of the products of my synthetic research in this context.
For all these classes of molecules, whose computer-assisted evaluation is performed in collaboration with other researchers, I study the possibility to interact with targets of biomedical importance by CD and UV spectroscopies.
My biomolecular targets consist e.g. in nucleic acids [poly rA (3' mRNA tail), G-quadruplex forming DNAs et.c.], peptides and proteins (HIV RT, serum albumins et.c.) and still others.
I test metal-ion [Cu (II), Ni (II)..] binding of my molecules by UV, whereas I use DLS for investigating their supramolecular assembly, which often influences their activity.
The possible applications that I am studying for my compounds belong to the fields of anticancer, antiviral and anti-neurodegeneration therapies, but other new horizons are opened.....
Vitiello M, Finamore E, Falanga A, Raieta K, Cantisani M, Galdiero F, Pedone C, Galdiero M, Galdiero S * Fusion in Coq(107 visite) Lecture Notes In Computer Science (ISSN: 0302-9743, 0302-974335404636319783540463634, 0302-974335402975459783540297543), 2001; 2178LNCS: 583-596. Impact Factor:0.415 DettagliEsporta in BibTeXEsporta in EndNote
377 Records (358 escludendo Abstract e Conferenze). Impact factor totale: 1240.344 (1193.262 escludendo Abstract e Conferenze). Impact factor a 5 anni totale: 1263.805 (1215.001 escludendo Abstract e Conferenze).
ibb.cnr.it
