MFAG grant financed by AIRC (Associazione Italiana per la Ricerca sul Cancro)
Starting Date: January 2nd 2015
Project Title: Structure-based design of anti-cancer therapeutics targeting the Sam domain of Ephrin A2 receptor
PI: Marilisa Leone (Researcher)
Fellow: Flavia Anna Mercurio
The overall goal of the project is to design molecule antagonists of heterotypic Sam (Sterile Alpha Motif)-Sam domain interactions involving the EphA2 receptor, and evaluate their ability to modulate receptor endocytosis and consequent degradation. EphA2 is over-expressed in many tumors and exhibits several pro-cancer activities; the process of receptor endocytosis is under investigation as a potential route to reduce tumor malignancy.
The project relies on a multidisciplinary approach based on extensive use of solution NMR (Nuclear Magnetic Resonance) techniques, molecular modeling, CD (Circular Dichroism), ITC (Isothermal Titration Calorimetry), SPR (Surface Plasmon Resonance) and in vitro cell-based assays.
Link to the Airc website: http://www.airc.it/finanziamenti/ricerca/under-40/