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Name NomeMarilisa Leone
AreaResearch&Development Ricerca e Sviluppo
Position QualificaResearcher Ricercatore
Work site SedeNaples-Mezzocannone Napoli-Mezzocannone
Address IndirizzoVia Mezzocannone 16, 80134 Naples - Italy Napoli - Italia
E-mailmarilisa.leonecnr.it
Office phone Telefono ufficio+39 0812534512
▼    Structure and function of proteins involved in physio-pathologic processes Struttura e funzione di proteine coinvolte in processi fisiopatologici
▼    Carbonic Anhydrase IX as target for the development of new anti-tumour drugs L’Anidrasi Carbonica IX come target per lo sviluppo di nuovi farmaci antitumorali
▼    Biomolecole in grado di modulare l’angiogenesi VEGF-dipendente Biomolecules able to modulate the VEGF-dependent angiogenesis
▼    A multi-targeting approach to fight COVID-19 Un approccio multi-targeting per combattere COVID-19
▼    Galectins: Structure, function and therapeutic potential inhibitors Galectine: struttura, funzione e potenziali inibitori terapeutici
▼    Caratterizzazione della famiglia proteica delle KCTD: fattori chiave in diversi processi biologici Characterization of the KCTD protein family: key factors in several biological processes
▼    Sintesi chimica e modificazione di proteine per applicazioni in campo biomedico Chemical protein synthesis and modification for biomedical applications
▼    Protein-Protein-Interaction network–disease relationship, pathogenicity and therapeutic perspectives Relazione tra malattia e alterate interazioni proteina-proteina: patogenicità e prospettive terapeutiche
▼    Biomolecular NMR: structural studies of proteins and peptides and drug discovery applications Risonanza magnetica nucleare biomolecolare: studi strutturali di proteine e peptidi e applicazioni per il “drug discovery”
▼    Structural characterization of the porphyrins/proteasome interaction Caratterizzazione strutturale dell’interazione porfirine/proteosoma
▼    Axl and Gas6 targeting for therapeutic and diagnostic applications Molecole che bersagliano Axl e Gas6 per applicazioni a scopo terapeutico e diagnostico
▼    Drug discovery by mirror-image phage display Drug discovery attraverso l’impiego della tecnologia del mirror-image phage display
▼    Analysis of Sam domain druggability through computational and experimental studies I domini Sam come bersagli farmacologici: studi computazionali e sperimentali
▼    Targeting Sam-Sam interactions mediated by EphA2 receptor: design and evaluation of peptide inhibitors Progettazione e validazione di peptidi inibitori delle interazioni Sam-Sam mediate dal recettore EphA2
▼    Synthesis of small molecules, modified peptides and nucleobase-decorated peptides. Spectroscopic and computational investigation on the potential of natural product in biomedicine. Nucleic acid and protein binding studies Sintesi di small molecules, peptidi modificati e peptidi decorati con nucleobasi. Valutazione spettroscopica e computazionale del potenziale di prodotti naturali in biomedicina. Studi di interazione molecolare con acidi nucleici e proteine
▼    Biochemical and functional characterization of intrinsically disordered proteins (IDPs) in human diseases Caratterizzazione biochimica e funzionale di proteine intrinsecamente disordinate e loro ruolo nelle malattie umane
▼    Biochemical and functional characterization of Protein-Protein and DNA-protein Interaction networks in physio/pathological events Caratterizzazione biochimica e funzionale di interazioni proteina-proteina e DNA-proteina in eventi fisio/patologici
▼    Biochemical and structural insights on Chromatin Assembly Factor 1 in physio/pathological events Studi biochimici e molecolari sul Fattore di Assemblaggio della Cromatina 1 coinvolta in eventi fisiopatologici
▼    Targeting Of Protein-Protein Interactions For Therapeutic Purposes Targeting delle interazioni proteina-proteina per scopi terapeutici
▼    Small molecules and peptides/modified peptides for diagnostic, therapeutic and biotechnological applications Piccole molecole e peptidi/peptidi modificati per applicazioni diagnostiche, terapeutiche e biotecnologiche
▼    Biomolecole in grado di modulare l’angiogenesi VEGF-dipendente Biomolecules able to modulate the VEGF-dependent angiogenesis
▼    New peptide–based molecules as NGF mimetics in the therapy of neurological dysfunctions Nuove molecole di natura peptidica che mimano l’NGF per la terapia di malattie neurologiche
▼    Peptide-based molecules for αvβ3 integrin modulation in Th17 cells-dependent demyelinating diseases Molecole di natura peptidica per modulare l’attività dell’integrina αvβ3 nelle malattie demielinizzanti Th17 dipendenti
▼    Development of integrin subtypes selective ligands: from a first rationally designed peptide to a wide range of molecules Sviluppo di ligandi selettivi per i sottotipi di integrine: dal primo peptide progettato su base razionale verso un ampio spettro di molecole
▼    Design of New FSHR-Specific Peptides for therapeutic and diagnostic applications Progettazione di nuovi peptidi specifici per il recettore dell’FSH per applicazioni diagnostiche e terapeutiche
▼    New synthetic molecules for active targeting of multifunctional theranostic nanosystems Nuove molecole sintetiche per il trasporto attivo di nanosistemi multifunzionali teranostici
▼    Biomolecular NMR: structural studies of proteins and peptides and drug discovery applications Risonanza magnetica nucleare biomolecolare: studi strutturali di proteine e peptidi e applicazioni per il “drug discovery”
▼    Galectins: Structure, function and therapeutic potential inhibitors Galectine: struttura, funzione e potenziali inibitori terapeutici
▼    Protein-Protein-Interaction network–disease relationship, pathogenicity and therapeutic perspectives Relazione tra malattia e alterate interazioni proteina-proteina: patogenicità e prospettive terapeutiche
▼    A multi-targeting approach to fight COVID-19 Un approccio multi-targeting per combattere COVID-19
▼    Axl and Gas6 targeting for therapeutic and diagnostic applications Molecole che bersagliano Axl e Gas6 per applicazioni a scopo terapeutico e diagnostico
▼    Drug discovery by mirror-image phage display Drug discovery attraverso l’impiego della tecnologia del mirror-image phage display
▼    Peptides of therapeutic interest with antimicrobial and/ or antitumoral activity Peptidi di interesse terapeutico con attività antimicrobica e/o antitumorale
▼    Analysis of Sam domain druggability through computational and experimental studies I domini Sam come bersagli farmacologici: studi computazionali e sperimentali
▼    Targeting Sam-Sam interactions mediated by EphA2 receptor: design and evaluation of peptide inhibitors Progettazione e validazione di peptidi inibitori delle interazioni Sam-Sam mediate dal recettore EphA2
▼    Synthesis of small molecules, modified peptides and nucleobase-decorated peptides. Spectroscopic and computational investigation on the potential of natural product in biomedicine. Nucleic acid and protein binding studies Sintesi di small molecules, peptidi modificati e peptidi decorati con nucleobasi. Valutazione spettroscopica e computazionale del potenziale di prodotti naturali in biomedicina. Studi di interazione molecolare con acidi nucleici e proteine
▼    Plant polypeptides as natural enhancers of biostimulation Polipeptidi vegetali come potenziatori naturali della biostimolazione
▼    Chemical modification of natural molecules, such as peptides and polysaccharides, to be employed as therapeutic agents as well as sensor diagnostic tools Modifiche chimiche eseguite su molecole naturali, quali peptide e polisaccaridi, e loro impiego come agenti terapeutici e sonde diagnostiche
▼    Design and screening of molecular repertoires as a source for new bioactive compounds Progettazione e screening di repertori molecolari come fonte di nuovi composti bioattivi
▼    Targeting Of Protein-Protein Interactions For Therapeutic Purposes Targeting delle interazioni proteina-proteina per scopi terapeutici
▼    Macromolecules for biomedical and biotechnological applications Macromolecole per applicazioni biomediche e biotecnologiche
▼    Protein-Protein-Interaction network–disease relationship, pathogenicity and therapeutic perspectives Relazione tra malattia e alterate interazioni proteina-proteina: patogenicità e prospettive terapeutiche
▼    A multi-targeting approach to fight COVID-19 Un approccio multi-targeting per combattere COVID-19
▼    Galectins: Structure, function and therapeutic potential inhibitors Galectine: struttura, funzione e potenziali inibitori terapeutici
▼    Caratterizzazione della famiglia proteica delle KCTD: fattori chiave in diversi processi biologici Characterization of the KCTD protein family: key factors in several biological processes
▼    Sintesi chimica e modificazione di proteine per applicazioni in campo biomedico Chemical protein synthesis and modification for biomedical applications
▼    Biomolecole in grado di modulare l’angiogenesi VEGF-dipendente Biomolecules able to modulate the VEGF-dependent angiogenesis
▼    Biomolecular NMR: structural studies of proteins and peptides and drug discovery applications Risonanza magnetica nucleare biomolecolare: studi strutturali di proteine e peptidi e applicazioni per il “drug discovery”
▼    Axl and Gas6 targeting for therapeutic and diagnostic applications Molecole che bersagliano Axl e Gas6 per applicazioni a scopo terapeutico e diagnostico
▼    Generation of innovative scaffolds by manipulating hyperstable proteins Design di scaffold innovativi mediante l’ingegnerizzazione di proteine termostabili
▼    The fine structure of proteins as a new tool for protein structure validation, quality assessment, and prediction La strutture fine delle proteine: un nuovo strumento per la validazione e la predizione della loro struttura tridimensionale
▼    Carbonic Anhydrase IX as target for the development of new anti-tumour drugs L’Anidrasi Carbonica IX come target per lo sviluppo di nuovi farmaci antitumorali
▼    Biochemical and functional characterization of intrinsically disordered proteins (IDPs) in human diseases Caratterizzazione biochimica e funzionale di proteine intrinsecamente disordinate e loro ruolo nelle malattie umane
▼    Biochemical and functional characterization of Protein-Protein and DNA-protein Interaction networks in physio/pathological events Caratterizzazione biochimica e funzionale di interazioni proteina-proteina e DNA-proteina in eventi fisio/patologici
▼    Biochemical and structural insights on Chromatin Assembly Factor 1 in physio/pathological events Studi biochimici e molecolari sul Fattore di Assemblaggio della Cromatina 1 coinvolta in eventi fisiopatologici
▼    Plant polypeptides as natural enhancers of biostimulation Polipeptidi vegetali come potenziatori naturali della biostimolazione
▼    Chemical modification of natural molecules, such as peptides and polysaccharides, to be employed as therapeutic agents as well as sensor diagnostic tools Modifiche chimiche eseguite su molecole naturali, quali peptide e polisaccaridi, e loro impiego come agenti terapeutici e sonde diagnostiche
▼    Protein-based biotherapeutics Bioterapeutici a base di proteine
▼    Understanding SARS-CoV-2 interaction with its host of for therapeutic applications Studi di interazioni patogeno-ospite in SARS-CoV-2

La Dott.ssa Marilisa Leone è nata il 28 aprile 1975. Ha conseguito la Laurea in Chimica (110/110 e lode) nel 1999 e il Dottorato di Ricerca in Scienze Chimiche (Materia: NMR di proteine) nel 2003 presso l'Università “Federico II” di Napoli. Ha acquisito grande esperienza sulle tecniche NMR per lo studio della struttura e interazioni di proteine e nel campo del “drug discovery” presso il “Burnham Institute for Medical Research” di San Diego (USA) (2002-2003 e 2005-2009). Nel 2009 è stata assunta come ricercatrice a tempo indeterminato dal Consiglio Nazionale delle Ricerche (CNR-IBB). Attualmente è coautrice di oltre 70 articoli su riviste internazionali “peer-reviewed” e membro del comitato editoriale della rivista NPG "Scientific Reports" e della rivista MDPI "Molecules".

CAPACITÀ E COMPETENZE TECNICHE: Espressione e purificazione di proteine, acquisizione e analisi di dati NMR, progettazione di librerie di peptidi / piccole molecole per approcci di screening basati su NMR, tecniche NMR in “drug discovery”, calcoli di struttura di proteine e peptidi mediante dati NMR, docking molecolare e progettazione di farmaci.

PREMI: (gennaio 2015-gennaio 2018) My First Airc Grant (MFAG15831 - AIRC: Associazione Italiana per la Ricerca sul Cancro); (Settembre 2006) Vincitrice del Premio per giovani ricercatori della Società Chimica Italiana – Divisione di Chimica dei sistemi biologici "Gastone De Santis-ITALFARMACO-2006".

Dr. Marilisa Leone was born on April 28th 1975. She gained a Master Degree in Chemistry (110/110 cum laude) in 1999 and a PhD in Chemical Sciences (Subject: protein NMR) in 2003 from the University “Federico II” of Naples. She was largely trained in the field of NMR-based drug discovery at the Burnham Institute for Medical Research in San Diego (USA) (2002-2003 and 2005-2009). In 2009 she was recruited as a permanent Researcher by the National Research Council of Italy (CNR-IBB). She is to-date co-author of more than 70 articles on international peer-reviewed journals and editorial board member of the NPG journal “Scientific Reports” and MDPI journal “Molecules”.

TECHNICAL SKILLS AND COMPETENCES: Protein expression and purification, NMR data acquisition and analysis, design of peptide/small molecule libraries for NMR-based screening approaches, NMR screening techniques, protein and peptide structure calculations by NMR data, molecular docking techniques & structure-based drug design.

AWARDS: (January 2015-January 2018) My First Airc Grant (MFAG15831 from AIRC: Italian Association for Cancer Research); (September 2006) Winner of the Italian Award "Premio Gastone De Santis-ITALFARMACO-2006” for young researchers.

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Publications Pubblicazioni
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* The fight against human viruses: how NMR can help (39 views visite)
Vincenzi M, Leone M
Curr Med Chem (ISSN: 0929-8673linking), 2020 Dec 28; N/D: N/D-N/D.
Impact Factor: 4.184
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* Structural Insights on Tiny Peptide Nucleic Acid (PNA) Analogues of miRNA-34a: An in silico and Experimental Integrated Approach (43 views visite)
Moccia M, Mercurio FA, Langella E, Piacenti V, Leone M, Adamo MFA, Saviano M
Front Chem (ISSN: 2296-2646linking), 2020 Nov 23; 8: 568575-568575.
Impact Factor: 3.693
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* NMR spectroscopy in the conformational analysis of peptides: an overview (43 views visite)
Vincenzi M, Mercurio FA, Leone M
Curr Med Chem (ISSN: 0929-8673linking), 2020 Jul 2; N/D: N/D-N/D.
Impact Factor: 4.184
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* Chimeric Peptidomimetics of SOCS 3 Able to Interact with JAK2 as Anti-inflammatory Compounds (32 views visite)
La Manna S, Lopez-sanz L, Mercurio FA, Fortuna S, Leone M, Gomez-guerrero C, Marasco D
Acs Med Chem Lett (ISSN: 1948-5875linking), 2020 May 14; 11(5): 615-623.
Impact Factor: 3.975
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* Exploring the ability of cyclic peptides to target SAM domains: a computational and experimental study (222 views visite)
Mercurio FA, Di Natale C, Pirone L, Vincenzi M, Marasco D, De Luca S, Pedone EM, Leone M
Chembiochem (ISSN: 1439-4227linking, 1439-7633), 2020 Mar 2; 21(5): 702-711.
Impact Factor: 2.641
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* Protein Interaction Domains: structural features and drug discovery applications (part 2) (44 views visite)
Vincenzi M, Mercurio FA, Leone M
Curr Med Chem (ISSN: 0929-8673linking), 2020 Jan 13; N/D: N/D-N/D.
Impact Factor: 4.184
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* Protein Interaction Domains and Post-Translational Modifications: Structural Features and Drug Discovery Applications (45 views visite)
Vincenzi M, Mercurio FA, Leone M
Curr Med Chem (ISSN: 0929-8673linking), 2020; 27(37): 6306-6355.
Impact Factor: 4.184
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* Sam Domains in Multiple Diseases (200 views visite)
Vincenzi M, Mercurio FA, Leone M
Curr Med Chem (ISSN: 0929-8673linking, 1875-533xelectronic), 2020; 27(3): 450-476.
Impact Factor: 3.469
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* Monoacylglycerides from the Diatom Skeletonema marinoi Induce Selective Cell Death in Cancer Cells (114 views visite)
Miceli M, Cutignano A, Conte M, Ummarino R, Romanelli A, Ruvo M, Leone M, Mercurio FA, Doti N, Manzo E, Romano G, Altucci L, Ianora A
Mar Drugs (ISSN: 1660-3397linking), 2019 Nov 1; 17 (11 ): N/D-N/D.
Impact Factor: 3.345
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* Design and analysis of EphA2-SAM peptide ligands: A multi-disciplinary screening approach (188 views visite)
Mercurio FA, Di Natale C, Pirone L, Marasco D, Calce E, Vincenzi M, Pedone EM, De Luca S, Leone M
Bioorg Chem (ISSN: 0045-2068linking, 1090-2120electronic), 2019 Mar; 84: 434-443.
Impact Factor: 3.929
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* The Growth Differentiation Factor 11 is Involved in Skin Fibroblast Ageing and is Induced by a Preparation of Peptides and Sugars Derived from Plant Cell Cultures (265 views visite)
Tito A, Barbulova A, Zappelli C, Leone M, Ruvo M, Mercurio FA, Chambery A, Russo R, Colucci MG, Apone F
Mol Biotechnol (ISSN: 1073-6085linking, 1559-0305electronic), 2019 Mar; 61 (3 ): 209-220.
Impact Factor: 2.275
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* About TFE: Old and New Findings (68 views visite)
Vincenzi M, Mercurio FA, Leone M
Curr Protein Pept Sci (ISSN: 1389-2037linking), 2019; 20 (5 ): 425-451.
Impact Factor:
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* Sam domain-based stapled peptides: Structural analysis and interaction studies with the Sam domains from the EphA2 receptor and the lipid phosphatase Ship2 (289 views visite)
Mercurio FA, Pirone L, Di Natale C, Marasco D, Pedone EM, Leone M
Bioorg Chem (ISSN: 0045-2068linking, 1090-2120electronic), 2018 Oct; 80: 602-610.
Impact Factor: 3.9
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* The antimicrobial peptides casocidins I and II: Solution structural studies in water and different membrane-mimetic environments (244 views visite)
Mercurio FA, Scaloni A, Caira S, Leone M
Peptides (ISSN: 0196-9781linking, 1873-5169electronic), 2018 Sep 19; 114: 50-58.
Impact Factor: 2.851
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* Biochemical, biophysical and molecular dynamics studies on the proteoglycan-like domain of carbonic anhydrase IX (277 views visite)
Langella E, Buonanno M, Vullo D, Dathan N, Leone M, Supuran C, De Simone G, Monti SM
Cell Mol Life Sci (ISSN: 1420-682xlinking), 2018 Sep; 75(17): 3283-3296.
Impact Factor: 6.721
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* Metabolomic and oxidative effects of quantum dots-indolicidin on three generations of Daphnia magna (63 views visite)
Falanga A, Mercurio FA, Siciliano A, Lombardi L, Galdiero S, Guida M, Libralato G, Leone M, Galdiero E
Aquat Toxicol (ISSN: 0166-445xlinking), 2018 May; 198: 158-164.
Impact Factor:
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* Self-Assembling of Fmoc-GC Peptide Nucleic Acid Dimers into Highly Fluorescent Aggregates (327 views visite)
Avitabile C, Diaferia C, Della Ventura B, Mercurio FA, Leone M, Roviello V, Saviano M, Velotta R, Morelli G, Accardo A, Romanelli A
Chemistry (ISSN: 1521-3765electronic, 0947-6539linking), 2018 Mar 26; 24(18): 4729-4735.
Impact Factor: 5.476
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* Prosystemin, a prohormone that modulates plant defense barriers, is an intrinsically disordered protein (308 views visite)
Buonanno M, Coppola M, Di Lelio I, Molisso D, Leone M, Pennacchio F, Langella E, Rao R, Monti SM
Protein Sci (ISSN: 1469-896xelectronic, 0961-8368linking), 2018 Mar; 27(3): 620-632.
Impact Factor: 2.937
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* The Sam-Sam interaction between Ship2 and the EphA2 receptor: design and analysis of peptide inhibitors (231 views visite)
Mercurio FA, Di Natale C, Pirone L, Iannitti R, Marasco D, Pedone EM, Palumbo R, Leone M
Sci Rep (ISSN: 2045-2322, 2045-2322electronic, 2045-2322linking), 2017 Dec 12; 7(1): 17474-17474.
Impact Factor: 4.122
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* Structure-activity studies of peptidomimetics based on kinase-inhibitory region of suppressors of cytokine signaling (369 views visite)
La Manna S, Lopez-sanz L, Leone M, Brandi P, Scognamiglio PL, Morelli G, Novellino E, Gomez-guerrero C, Marasco D
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2017 Nov 20; N/D: N/D-N/D.
Impact Factor: 1.99
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* Functional analyses yield detailedinsight into the mechanism of thrombin inhibition by the antihemostatic salivary protein cE5 from Anopheles gambiae (310 views visite) (PDF 175 views visite)
Pirone L, Ripoll-rozada J, Leone M, Ronca R, Lombardo F, Fiorentino G, Andersen JF, Pereira PJB, Arcà B, Pedone E
Jbc Papers (ISSN: 0021-9258linking, 1083-351x), 2017 Jul 28; 292(30): 12632-12642.
Impact Factor: 4.125
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* Structural investigation of a C-terminal EphA2 receptor mutant: Does mutation affect the structure and interaction properties of the Sam domain? (281 views visite)
Mercurio FA, Costantini S, Di Natale C, Pirone L, Guariniello S, Scognamiglio PL, Marasco D, Pedone EM, Leone M
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 1570-9639linking), 2017 Jun 06; 1865(9): 1095-1104.
Impact Factor: 4.28
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* Characterization of linear mimetic peptides of Interleukin-22 from dissection of protein interfaces (360 views visite)
La Manna S, Scognamiglio PL, Di Natale C, Leone M, Mercurio FA, Malfitano AM, Cianfarani F, Madonna S, Caravella S, Albanesi C, Novellino E, Marasco D
Biochimie (ISSN: 0300-9084, 1638-6183, 0300-9084linking), 2017 May 04; 138: 106-115.
Impact Factor: 3.188
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* Cross-beta nanostructures based on dinaphthylalanine Gd-conjugates loaded with doxorubicin (381 views visite)
Diaferia C, Gianolio E, Sibillano T, Mercurio FA, Leone M, Giannini C, Balasco N, Vitagliano L, Morelli G, Accardo A
Sci Rep (ISSN: 2045-2322, 2045-2322electronic, 2045-2322linking), 2017 Mar 22; 7(1): 307-307.
Impact Factor: 4.122
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* Targeting EphA2-Sam and Its Interactome: Design and Evaluation of Helical Peptides Enriched in Charged Residues (370 views visite)
Mercurio FA, Marasco D, Di Natale C, Pirone L, Costantini S, Pedone EM, Leone M
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-4227linking), 2016 Nov 17; 17(22): 2179-2188.
Impact Factor: 2.847
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* The Sam Domain of EphA2 receptor and its relevance to cancer: a novel challenge for drug discovery? (258 views visite)
Mercurio F, Leone M
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2016 Nov 01; 23(42): 4718-4734.
Impact Factor: 3.249
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* Destabilisation, aggregation, toxicity and cytosolic mislocalisation of nucleophosmin regions associated with acute myeloid leukemia (370 views visite)
Scognamiglio PL, Di Natale C, Leone M, Cascella R, Cecchi C, Lirussi L, Antoniali G, Riccardi D, Morelli G, Tell G, Chiti F, Marasco D
Oncotarget (ISSN: 1949-2553, 1949-2553electronic, 1949-2553linking), 2016 Sep 13; 7(37): 59129-59143.
Impact Factor: 5.168
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* Ac-LPFFD-Th: A Trehalose-Conjugated Peptidomimetic as a Strong Suppressor of Amyloid-beta Oligomer Formation and Cytotoxicity (407 views visite)
Sinopoli A, Giuffrida A, Tomasello MF, Giuffrida ML, Leone M, Attanasio F, Caraci F, De Bona P, Naletova I, Saviano M, Copani A, Pappalardo G, Rizzarelli E
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-4227linking), 2016 Aug 17; 17(16): 1541-1549.
Impact Factor: 2.847
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* Self-assembly of PEGylated tetra-phenylalanine derivatives: structural insights from solution and solid state studies (244 views visite)
Diaferia C, Mercurio FA, Giannini C, Sibillano T, Morelli G, Leone M, Accardo A
Sci Rep (ISSN: 2045-2322, 2045-2322electronic, 2045-2322linking), 2016 May 25; 6: 26638-26638.
Impact Factor: 4.259
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* Eco-friendly microwave-assisted protocol to prepare hyaluronan-fatty acid conjugates and to induce their self-assembly process (315 views visite)
Calce E, Mercurio F, Leone M, Saviano M, De Luca S
Carbohyd Polym (ISSN: 0144-8617), 2016 Feb; 143: 84-89.
Impact Factor: 4.811
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* Solid-Phase S-Alkylation Promoted by Molecular Sieves (228 views visite)
Calce E, Leone M, Mercurio FA, Monfregola L, De Luca S
Org Lett (ISSN: 1523-7060, 1523-7052, 1523-7052electronic), 2015 Nov 20; 17(22): 5646-5649.
Impact Factor: 6.732
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* Design and activity of a cyclic mini-beta-defensin analog: a novel antimicrobial tool (264 views visite)
Scudiero O, Nigro E, Cantisani M, Colavita I, Leone M, Mercurio FA, Galdiero M, Pessi A, Daniele A, Salvatore F, Galdiero S
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1176-9114linking), 2015 Oct 15; 10: 6523-6539.
Impact Factor: 4.32
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* Intrinsically disordered amphiphilic peptides as potential targets in drug delivery vehicles (363 views visite)
Vincenzi M, Accardo A, Costantini S, Scala S, Portella L, Trotta A, Ronga L, Guillon J, Leone M, Colonna G, Rossi F, Tesauro D
Mol Biosyst (ISSN: 1742-206x), 2015 Oct 13; 11(11): 2925-2932.
Impact Factor: 2.829
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* Nucleophosmin contains amyloidogenic regions that are able to form toxic aggregates under physiological conditions (292 views visite)
Di Natale C, Scognamiglio PL, Cascella R, Cecchi C, Russo A, Leone M, Penco A, Relini A, Federici L, Di Matteo A, Chiti F, Vitagliano L, Marasco D
The Faseb Journal (ISSN: 1530-6860, 1530-6860electronic), 2015 Sep; 29(9): 3689-3701.
Impact Factor: 5.043
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* A biocompatible process to prepare hyaluronan-based material able to self-assemble into stable nano-particles (329 views visite)
Calce E, Ringhieri P, Mercurio FA, Leone M, Bugatti V, Saviano M, Vittoria V, De Luca S
Rsc Adv (ISSN: 2046-2069), 2015; 5(37): 29573-29576.
Impact Factor: 3.289
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* Conformational ensembles explored dynamically from disordered peptides targeting chemokine receptor CXCR4 (486 views visite)
Vincenzi M, Costantini S, Scala S, Tesauro D, Accardo A, Leone M, Colonna G, Guillon J, Portella L, Trotta AM, Ronga L, Rossi F
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2015; 16(6): 12159-12173.
Impact Factor: 3.257
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* Peptide Fragments of Odin-Sam1: Conformational Analysis and Interaction Studies with EphA2-Sam (414 views visite)
Mercurio FA, Di Natale C, Pirone L, Scognamiglio PL, Marasco D, Pedone EM, Saviano M, Leone M
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-4227linking), 2015; 16(11): 1629-1636.
Impact Factor: 2.85
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* Cd And Nmr Conformational Studies Of A Peptide Encompassing The Mid Loop Interface Of Ship2-Sam (298 views visite)
Mercurio FA, Scognamiglio PL, Di Natale C, Marasco D, Pellecchia M, Leone M
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2014 Nov; 101(11): 1088-1098.
Impact Factor: 2.385
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* Structural insights into and activity analysis of the antimicrobial peptide myxinidin (591 views visite)
Cantisani M, Finamore E, Mignogna E, Falanga A, Nicoletti GF, Pedone C, Morelli G, Leone M, Galdiero M, Galdiero S
Antimicrob Agents Ch (ISSN: 0066-4804, 1098-6596), 2014 Sep; 58(9): 5280-5290.
Impact Factor: 4.476
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* G-quadruplex DNA recognition by nucleophosmin: new insights from protein dissection (361 views visite)
Scognamiglio PL, Di Natale C, Leone M, Poletto M, Vitagliano L, Tell G, Marasco D
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 1570-9639print), 2014 Jun; 1840(6): 2050-2059.
Impact Factor: 5.353
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* Conformational Disorder In Phosphopeptides: Solution Studies By Cd And Nmr Techniques (341 views visite)
Leone M, Mercurio FA, Vincenzi M, Accardo A, Ringhieri P, Tesauro D, Carrière F, Rossi F
Peptidomics, 2014; 1: 14-21.
Impact Factor: 0
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* Lipidated Peptides Via Post-Synthetic Thioalkylation Promoted By Molecular Sieves (429 views visite)
Calce E, Leone M, Monfregola L, De Luca S
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2014; 46(8): 1899-1905.
Impact Factor: 3.293
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* Structure-Activity Relations of Myxinidin, an Antibacterial Peptide Derived from the Epidermal Mucus of Hagfish (504 views visite)
Cantisani M, Leone M, Mignogna E, Kampanaraki K, Falanga A, Morelli G, Galdiero M, Galdiero S
Antimicrob Agents Ch (ISSN: 0066-4804, 1098-6596), 2013 Nov; 57(11): 5665-5673.
Impact Factor: 4.451
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* Heterotypic Sam-Sam Association Between Odin-Sam1 And Arap3-Sam: Binding Affinity And Structural Insights (299 views visite)
Mercurio FA, Marasco D, Pirone L, Scognamiglio PL, Pedone E, Pellecchia M, Leone M
Chembiochem (ISSN: 1439-4227, 1439-9422, 1439-7633), 2013 Jan 2; 14(1): 100-106.
Impact Factor: 2.92
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* Chemical Modifications Of Peptide Sequences Via S-Alkylation Reaction (299 views visite)
Calce E, Leone M, Monfregola L, De Luca S
Org Lett (ISSN: 1523-7060, 1523-7052, 1523-7052electronic), 2013; 15(20): 5354-5357.
Impact Factor: 6.324
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* Solution conformational features and interfacial properties of an intrinsically disordered peptide coupled to alkyl chains: A new class of peptide amphiphiles (375 views visite)
Accardo A, Leone M, Tesauro D, Aufiero R, Bénarouche A, Cavalier JF, Longhi S, Carriere F, Rossi F
Mol Biosyst (ISSN: 1742-206x), 2013; 9(6): 1401-1410.
Impact Factor: 3.183
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* Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells (419 views visite)
Lirussi L, Antoniali G, Vascotto C, D'Ambrosio C, Poletto M, Romanello M, Marasco D, Leone M, Quadrifoglio F, Bhakat KK, Scaloni A, Tell G
Mol Biol Cell (ISSN: 1059-1524), 2012 Oct 15; 23(20): 4079-4096.
Impact Factor: 4.803
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* Postsynthetic modification of peptides via chemoselective N-alkylation of their side chains (402 views visite)
Monfregola L, Leone M, Calce E,  de Luca S
Org Lett (ISSN: 1523-7060, 1523-7052, 1523-7052electronic), 2012 Apr 6; 14(7): 1664-1667.
Impact Factor: 6.142
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* Gold nanoparticles capped by a GC-containing peptide functionalized with an RGD motif for integrin targeting (472 views visite)
Scarí G, Porta F, Fascio U, Avvakumova S, Dal Santo V, De Simone M, Saviano M, Leone M, Del Gatto A, Pedone C, Zaccaro L
Bioconjug Chem (ISSN: 1520-4812, 1043-1802, 1520-4812electronic), 2012 Mar 21; 23(3): 340-349.
Impact Factor: 4.58
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* Solution Structure of the First Sam Domain of Odin and Binding Studies with the EphA2 Receptor (398 views visite)
Mercurio FA, Marasco D, Pirone L, Pedone E, Pellecchia M,  Leone M
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2012 Mar 13; 51(10): 2136-2145.
Impact Factor: 3.377
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* Zinc to Cadmium Replacement in the A. thaliana SUPERMAN Cys(2)His(2) Zinc Finger Induces Structural Rearrangements of Typical DNA Base Determinant Positions (354 views visite)
Malgieri G, Zaccaro L, Leone M, Bucci E, Esposito S, Baglivo I, Del Gatto A, Russo L, Scandurra R, Pedone PV, Fattorusso R, Isernia C
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2011 Nov; 95(11): 801-810.
Impact Factor: 2.87
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* Design and NMR Studies of Cyclic Peptides Targeting the N-Terminal Domain of the Protein Tyrosine Phosphatase YopH (2143 views visite)
Barile E, Leone M, Barile E, Dahl R, Pellecchia M
Chem Biol Drug Des Chemical Biology And Drug Design (ISSN: 1747-0277, 1747-0285), 2011 Jan; 77(1): 12-19.
Impact Factor: 2.282
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* Chemical modification of pectin: Environmental friendly process for new potential material development (247 views visite)
Monfregola L, Leone M, Vittoria V, Amodeo P, De Luca S
Polym Chem (ISSN: 1759-9954), 2011; 2(4): 800-804.
Impact Factor: 5.321
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* NMR-based design and evaluation of novel bidentate inhibitors of the protein tyrosine phosphatase YopH (406 views visite)
Leone M, Barile E, Vazquez J, Mei A, Guiney D, Dahl R, Pellecchia M
Chem Biol Drug Des Chemical Biology And Drug Design (ISSN: 1747-0277, 1747-0285), 2010 Jul; 76(1): 10-16.
Impact Factor: 2.527
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* Structural analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex (332 views visite)
Santelli E, Leone M, Li C, Fukushima T, Preece NE, Olson AJ, Ely KR, Reed JC, Pellecchia M, Liddington RC, Matsuzawa S-I
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2005 Oct 7; 280(40): 34278-34287.
Impact Factor: 5.854
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* Solution structure and backbone dynamics of the K18G/R82E Alicyclobacillus acidocaldarius thioredoxin mutant: A molecular analysis of its reduced thermal stability (323 views visite)
Leone M, Di Lello P, Ohlenschläger O, Pedone E, Bartolucci S, Rossi M, Di Blasio B, Pedone C, Saviano M, Isernia C, Fattorusso R
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2004 May 25; 43(20): 6043-6058.
Impact Factor: 4.008
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* NMR structure of the single QALGGH zinc finger domain from the Arabidopsis thaliana SUPERMAN protein (352 views visite)
Isernia C, Bucci E, Leone M, Zaccaro L, Di Lello P, Digilio G, Esposito S, Saviano M, Di Blasio B, Pedone C, Pedone PV, Fattorusso R
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003 Mar 3; 4(2-3): 171-180.
Impact Factor: 3.992
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* Structural investigation of the HIV-1 envelope glycoprotein gp160 cleavage site (349 views visite)
Oliva R, Leone M, Falcigno L, D'Auria G, Dettin M, Scarinci C, Di Bello C, Paolillo L
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2002 Mar 15; 8(6): 1467-1473.
Impact Factor: 4.238
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58 Records (58 excluding Abstracts and Conferences escludendo Abstract e Conferenze).
Total impact factor Impact factor totale: 217.655 (217.655 excluding Abstracts and Conferences escludendo Abstract e Conferenze).
Total 5 year impact factor Impact factor a 5 anni totale: 215.893 (215.893 excluding Abstracts and Conferences escludendo Abstract e Conferenze).


Last modified by Ultima modifica di Marco Comerci on in data Monday 07 December 2020, 11:11:12
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