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NomeKatia D'Ambrosio
AreaRicerca e Sviluppo
QualificaRicercatore
SedeNapoli-Mezzocannone
IndirizzoVia Mezzocannone 16, 80134 Napoli - Italia
E-mailkatia.dambrosiocnr.it
Telefono ufficio+39 081 253.20.44
    Malattie Neoplastiche
    Gadd45 beta and its implication in chronic inflammation
    Characterization of neurotoxic and neuroprotective factors by using computational methodologies
    Monoclonal Antibodies for therapeutic and diagnostic applications
    Targeted Drug Delivery by integrin avb3 antagonist
    Protein aggregation and cytotoxicity: molecular, in vitro and in vivo biological studies
    Metals role in angiogenesis
    Drug Delivery
    Bioactive peptide-membrane assemblies
    Metals and small molecules in the regulation of the Ubiquitin Proteasome Pathway
    Protein semi-synthesis for biophysical and chemical biology applications
    Peptide modulators of the VEGF-dependent angiogenesis
    Peptides promoting reverse cholesterol transport
    CA IX as target for the development of new anti-tumour drugs
    Carbonic Anhydrase family as target for rational drug design
    Clinical Oncology
    Translational Molecular Imaging in Cancer
    Molecular imaging for personalized therapy in oncology
    Modeling radiation induced normal tissue effects
    Synthesis of small molecules, modified peptides and nucleobase-decorated peptides. Nucleic acid and protein binding studies
    Segmentazione cerebrale per applicazioni in radiologia oncologica
    Altre Malattie
    Production and characterization of recombinant enzymes for biochemical and biotechnological applications
    Characterization of neurotoxic and neuroprotective factors by using computational methodologies
    Protein aggregation and cytotoxicity: molecular, in vitro and in vivo biological studies
    Metals role in angiogenesis
    Drug Delivery
    Bioactive peptide-membrane assemblies
    Protein semi-synthesis for biophysical and chemical biology applications
    Peptide modulators of the VEGF-dependent angiogenesis
    Peptides promoting reverse cholesterol transport
    Comparison of noninvasive cardiac imaging modalities in patients with myocardial infarction
    Structural and functional studies of virulence factors in Mycobacterium tuberculosis infection
    Assessment of the cardiac risk and its temporal variation
    Carbonic Anhydrase family as target for rational drug design
    Synthesis of small molecules, modified peptides and nucleobase-decorated peptides. Nucleic acid and protein binding studies
    Fenotipizzazione di modelli murini mediante imaging preclinico.

February 1999-June 1999: Guest Investigator at the Pharmaceutical Chemistry Department at the University of Montpellier (France) December 2000: Degree in Chemistry and Pharmaceutical technology at Chemistry of the natural substances Department, University of Naples "Federico II". September 2001-February 2003: Guest Investigator at the LCM3B, at the University Henry Poincair, Nancy (France). January 2004: International Ph. D. in Chemistry of Biological Processes at University of Naples "Federico II". November 2003-January2009: Associate researcher at Institute of Biostructures and Bioimages-CNR, Napoli with a fixed-term contract. February2009 up today: Permanent position as "researcher" at Institute of Biostructures and Bioimages-CNR. November 2006-March 2007: Professor in the formation project STRUIM, for the course Advances in crystallography basic knowledge. June 2006: Professor in the formation project for the Consortium ITALBIOTEC, for the course Structural analysis of biomolecules by X-ray diffraction techniques The scientific activity of Dr. DAmbrosio regards research topics of great interest, concerning the application of the most modern techniques of X-ray crystallography, for the detailed characterization of the three-dimensional structures of protein and protein complexes. The research activity of Dr. DAmbrosio can be summarized as it follows: -Structural characterization of proteins involved in oxidoreduction mechanisms-Structural characterization of proteins of enzymes from extremophiles-Structural characterization of proteins involved in different human pathologies-Structural characterization of protein-ligand complexes. Dr. DAmbrosio is involved in several national and international research projects, collaborating with a wide range of scientists and institutions (University of Florence, University of Nancy, France; Universit Montpellier II, France).


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Bibliografia

Ordina per:   data    titolo    rivista    autori    impact factor

* Inhibition of carbonic anhydrase IX targets primary tumors, metastases, and cancer stem cells: Three for the price of one (45 visite)
Supuran CT, Alterio V, Di Fiore A, D'Ambrosio K, Carta F, Monti SM, De Simone G
Med Res Rev (ISSN: 1098-1128electronic, 0198-6325linking), 2018 Sep; 38(6): 1799-1836.
Impact Factor: 8.29
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Are Carbonic Anhydrases Suitable Targets to Fight Protozoan Parasitic Diseases? (9 visite)
D'Ambrosio K, Supuran CT, De Simone G
Curr Med Chem (ISSN: 1875-533xelectronic, 0929-8673linking), 2018 Mar 26; N/D: N/D-N/D.
Impact Factor: 4.63
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Recent Advances in the Development of New Therapeutic Tools Against Major Parasitic Diseases (10 visite)
D'Ambrosio K, Supuran CT, De Simone G
Current Medicinal Chemistry, 2018; N/D: N/D-N/D.
Impact Factor: 3.853
Dettagli    Esporta in BibTeX    Esporta in EndNote

* L-Histidinol Dehydrogenase as a New Target for Old Diseases (120 visite)
Monti SM, De Simone G, D'Ambrosio K
Curr Top Med Chem (ISSN: 1568-0266linking, 1873-4294electronic), 2016 Apr 13; 16(21): 2369-2378.
Impact Factor: 2.864
Dettagli    Esporta in BibTeX    Esporta in EndNote

* A Combined Crystallographic and Theoretical Study Explains the Capability of Carboxylic Acids to Adopt Multiple Binding Modes in the Active Site of Carbonic Anhydrases (115 visite)
Langella E, D'Ambrosio K, D'Ascenzio M, Carradori S, Monti SM, Supuran CT, De Simone G
Chemistry (ISSN: 1521-3765electronic, 0947-6539linking), 2016 Jan 4; 22(1): 97-100.
Impact Factor: 5.317
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Editorial (Thematic Issue: Bacterial Metallo-Enzymes as Drug Targets) (63 visite)
Monti SM, D'Ambrosio K, De Simone G
Curr Top Med Chem (ISSN: 1873-4294electronic, 1568-0266linking), 2016; 16(21): 2329-2329.
Impact Factor: 2.864
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Human Carbonic Anhydrases: Catalytic Properties, Structural Features, and Tissue Distribution (95 visite)
D'Ambrosio K, De Simone G, Supuran CT
Carbonic Anhydrases As Biocatalysts, 2015 Jan 08; N/D: 17-30.
Impact Factor: 0
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Out of the active site binding pocket for carbonic anhydrase inhibitors (157 visite) (PDF 134 visite)
D'Ambrosio K, Carradori S, Monti SM, Buonanno M, Secci D, Vullo D, Supuran CT, De Simone G
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2015 Jan 7; 51(2): 302-305.
Impact Factor: 6.567
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Sulfolobus solfataricus thiol redox puzzle: characterization of an atypical protein disulfide oxidoreductase (164 visite)
Limauro D, De Simone G, Pirone L, Bartolucci S, D'Ambrosio K, Pedone E
Extremophiles (ISSN: 1431-0651, 1433-4909, 1433-4909electronic), 2014 Mar; 18(2): 219-228.
Impact Factor: 2.306
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Structural basis for the rational design of new anti-Brucella agents: The crystal structure of the C366S mutant of l-histidinol dehydrogenase from Brucella suis (149 visite)
D'Ambrosio K, Lopez M, Dathan NA, Ouahrani-bettache S, Köhler S, Ascione G, Monti SM, Winum JY, De Simone G
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2014 Feb; 97(1): 114-120.
Impact Factor: 2.963
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Multiple binding modes of inhibitors to carbonic anhydrases: How to design specific drugs targeting 15 different isoforms? (145 visite)
Alterio V, Di Fiore A, D'Ambrosio K, Supuran CT, De Simone G
Chemical Reviews (ISSN: 0009-2665), 2012 Sep; 112(8): 4421-4468.
Impact Factor: 41.298
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Development of potent carbonic anhydrase inhibitors incorporating both sulfonamide and sulfamide groups (134 visite)
D'Ambrosio K, Smaine F-Z, Carta F, De Simone G, Winum J-Y, Supuran CT
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2012; 55(15): 6776-6783.
Impact Factor: 5.614
Dettagli    Esporta in BibTeX    Esporta in EndNote

* C68 from the Sulfolobus islandicus plasmid-virus pSSVx is a novel member of the AbrB-like transcription factor family (177 visite)
Contursi P, D'Ambrosio K, Pirone L, Pedone E, Aucelli T, She Q, De Simone G, Bartolucci S
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2011 Apr 1; 435(1): 157-166.
Impact Factor: 4.897
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Multiple catalytically active thioredoxin folds: a winning strategy for many functions (176 visite)
Pedone E, Limauro D, D'Ambrosio K, De Simone G, Bartolucci S
Cell Mol Life Sci Cellular And Molecular Life Sciences (ISSN: 1420-682x), 2010 Nov; 67(22): 3797-3814.
Impact Factor: 7.047
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Exploring the catalytic mechanism of the first dimeric Bcp: Functional, structural and docking analyses of Bcp4 from Sulfolobus solfataricus (113 visite)
Limauro D, D'Ambrosio K, Langella E, De Simone G, Galdi I, Pedone C, Pedone E, Bartolucci S
Biochimie (ISSN: 1638-6183, 0300-9084, 1638-6183electronic), 2010 Oct; 92(10): 1435-1444.
Impact Factor: 3.787
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Insights into the catalytic mechanism of the Bcp family: functional and structural analysis of Bcp1 from Sulfolobus solfataricus (152 visite)
D'Ambrosio K, Limauro D, Pedone E, Galdi I, Pedone C, Bartolucci S, De Simone G
Proteins (ISSN: 1097-0134, 0887-3585, 1097-0134electronic), 2009 Sep; 76(4): 995-1006.
Impact Factor: 3.085
Dettagli    Esporta in BibTeX    Esporta in EndNote

* X-Ray Crystallography of Carbonic Anhydrase Inhibitors and Its Importance in Drug Design (124 visite)
Alterio V, Di Fiore A, D'Ambrosio K, Supuran CT, De Simone G
Drug Des Of Zinc Enzyme Inhibitors (ISSN: 9780-4702, 9780-470275009), 2009; N/D: 73-138.
Impact Factor: 1.156
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Ccarbonic Anhydrase Inhibitors: Bioreductive Nitro-Containing Sulfonamides With Selectivity For Targeting The Tumor Associated Isoforms Ix And Xii (145 visite)
D'Ambrosio K, Vitale R, Dogne J, Masereel B, Innocenti A, Scozzafava A, De Simone G, Supuran CT
J Med Chem (ISSN: 1520-4804, 0022-2623, 0022-2623print), 2008 Jun 12; 51(11): 3230-3237.
Impact Factor: 4.898
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Carbonic anhydrase inhibitors: Binding of indanesulfonamides to the human isoform II (155 visite)
D'Ambrosio K, Masereel B, Thiry A, Scozzafava A, Supuran CT, De Simone G
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2008 Mar; 3(3): 473-477.
Impact Factor: 3.15
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Invariant Thr(244) is essential for the efficient acylation step of the non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase from Streptococcus mutans (106 visite)
Pailot A, D'Ambrosio K, Corbier C, Talfournier F, Branlant G
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2006 Dec 15; 400: 521-530.
Impact Factor: 4.1
Dettagli    Esporta in BibTeX    Esporta in EndNote

* A novel member of the protein disulfide oxidoreductase family from Aeropyrum pernix K1: Structure, function and electrostatics (104 visite)
D'Ambrosio K, Pedone E, Langella E, De Simone G, Rossi M, Pedone C, Bartolucci S
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2006 Sep 29; 362(4): 743-752.
Impact Factor: 4.89
Dettagli    Esporta in BibTeX    Esporta in EndNote

* The first crystal structure of a thioacylenzyme intermediate in the ALDH family: New coenzyme conformation and relevance to catalysis (96 visite)
D'Ambrosio K, Pailot A, Talfournier F, Didierjean C, Benedetti E, Aubry A, Branlant G, Corbier C
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2006 Mar 7; 45(9): 2978-2986.
Impact Factor: 3.633
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Insights on a new PDI-like family: Structural and functional analysis of a protein disulfide oxidoreductase from the bacterium Aquifex aeolicus (160 visite)
Pedone E, D'Ambrosio K, De Simone G, Rossi M, Pedone C, Bartolucci S
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2006 Feb 10; 356(1): 155-164.
Impact Factor: 4.89
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II 'selective' inhibitor celecoxib (115 visite)
Di Fiore A, Pedone C, D'Ambrosio K, Scozzafava A, De Simone G, Supuran CT
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2006 Jan 15; 16(2): 437-442.
Impact Factor: 2.538
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Crystallization and preliminary X-ray diffraction studies of a protein disulfide oxidoreductase from Aeropyrum pernix K1 (100 visite)
D'Ambrosio K, De Simone G, Pedone E, Rossi M, Bartolucci S, Pedone C
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2005 Mar 1; 61(3): 335-336.
Impact Factor: 0.568
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Crystallization and preliminary X-ray diffraction studies of a protein disulfide oxidoreductase from Aquifex aeolicus (96 visite)
D'Ambrosio K, De Simone G, Pedone E, Rossi M, Bartolucci S, Pedone C
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2004 Nov; 60(11): 2076-2077.
Impact Factor: 1.693
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Crystallization and preliminary X-ray studies of the glutaredoxin from poplar in complex with glutathione (87 visite)
D'Ambrosio K, Kauffmann B, Rouhier N, Benedetti E, Jacquot JP, Aubry A, Corbier C
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2003 Jun; 59: 1043-1045.
Impact Factor: 2.208
Dettagli    Esporta in BibTeX    Esporta in EndNote



27 Records (27 escludendo Abstract e Conferenze).
Impact factor totale: 139.106 (139.106 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 144.831 (144.831 escludendo Abstract e Conferenze).








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