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NomeAnna Maria Santoro
AreaRicerca e Sviluppo
QualificaRicercatore
SedeCatania
Indirizzoc/o Dipartimento di Scienze Chimiche Viale Andrea Doria 6, 95125 Catania - Italy
E-mailannamaria.santorocnr.it
Telefono ufficio+39 095-7385096
    Malattie Neoplastiche
    Gadd45 beta and its implication in chronic inflammation
    Characterization of neurotoxic and neuroprotective factors by using computational methodologies
    Monoclonal Antibodies for therapeutic and diagnostic applications
    Targeted Drug Delivery by integrin avb3 antagonist
    Protein aggregation and cytotoxicity: molecular, in vitro and in vivo biological studies
    Metals role in angiogenesis
    Drug Delivery
    Bioactive peptide-membrane assemblies
    Metals and small molecules in the regulation of the Ubiquitin Proteasome Pathway
    Protein semi-synthesis for biophysical and chemical biology applications
    Peptide modulators of the VEGF-dependent angiogenesis
    Peptides promoting reverse cholesterol transport
    CA IX as target for the development of new anti-tumour drugs
    Carbonic Anhydrase family as target for rational drug design
    Clinical Oncology
    Translational Molecular Imaging in Cancer
    Molecular imaging for personalized therapy in oncology
    Modeling radiation induced normal tissue effects
    Synthesis of small molecules, modified peptides and nucleobase-decorated peptides. Nucleic acid and protein binding studies
    Segmentazione cerebrale per applicazioni in radiologia oncologica
    Altre Malattie
    Production and characterization of recombinant enzymes for biochemical and biotechnological applications
    Characterization of neurotoxic and neuroprotective factors by using computational methodologies
    Protein aggregation and cytotoxicity: molecular, in vitro and in vivo biological studies
    Metals role in angiogenesis
    Drug Delivery
    Bioactive peptide-membrane assemblies
    Protein semi-synthesis for biophysical and chemical biology applications
    Peptide modulators of the VEGF-dependent angiogenesis
    Peptides promoting reverse cholesterol transport
    Comparison of noninvasive cardiac imaging modalities in patients with myocardial infarction
    Structural and functional studies of virulence factors in Mycobacterium tuberculosis infection
    Assessment of the cardiac risk and its temporal variation
    Carbonic Anhydrase family as target for rational drug design
    Synthesis of small molecules, modified peptides and nucleobase-decorated peptides. Nucleic acid and protein binding studies
    Fenotipizzazione di modelli murini mediante imaging preclinico.
    Metals role in angiogenesis

Born in Catania on 11th November 1965. July 1989: Degree in Biological Sciences cum laude. 1989-1990: Apprenticeship at Genetics Laboratories of Biology Department, University of Catania. 1990-1994: Research fellowship sponsored by the Consorzio Catania Ricerche, and Consiglio Nazionale delle Ricerche (CNR), in Bioinorganic laboratories at Chemistry Department of Catania University. 1995-1998: Ph. D. in Biochemistry and Molecular Biology, University of Catania. 1998-2000: Reseacher fellowship in Bioinorganic laboratories at Chemistry Department of Catania University. January 2001-CNR researcher in Catanias Institute section of IBB (Catania). Her experience has been enriched by some stages in european laboratories: Department of Radiation Genetics and Chemical Mutagenesis (Prof. A. T. Natarajan), University of Leiden, Nederland, Department of Biochemistry of Genoa University (Prof. A. De Flora). Centre de Biologie et Physiologie Vegetales, (Prof. A. M. Boudet) Universit Paul Sabatier Toulouse, France, Department of Biochemistry of Naples University (Prof. G. Sannia). Her main scientific interests are in the fields of biological chemistry and bioinorganic chemistry. In particular she has been involved in: biological activity of metal complexes (antitumor, antidiabetes, antiflammatory), studies of metalloenzymes in biotechnology (laccases), nitric oxide biological chemistry, misfolding diseases (prion diseases) and recently in role of metal ions in angiogenic processes and in studies on proteasome inhibitors.


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Bibliografia

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* The insulin-degrading enzyme is an allosteric modulator of the 20S proteasome and a potential competitor of the 19S (12 visite) (PDF 6 visite)
Sbardella D, Tundo GR, Coletta A, Marcoux J, Koufogeorgou EI, Ciaccio C, Santoro AM, Milardi D, Grasso G, Cozza P, Bousquet-dubouch MP, Marini S, Coletta M
Cellular And Molecular Life Sciences (ISSN: 1420-9071electronic, 1420-682xlinking), 2018 Sep; 75(18): 3441-3456.
Impact Factor: 7.047
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Electrostatic Map Of Proteasome alpha-Rings Encodes The Design of Allosteric Porphyrin-Based Inhibitors Able To Affect 20S Conformation By Cooperative Binding (65 visite)
Dato AD, Cunsolo A, Persico M, Santoro AM, D'Urso A, Milardi D, Purrello R, Stefanelli M, Paolesse R, Tundo GR, Sbardella D, Fattorusso C, Coletta M
Sci Rep (ISSN: 2045-2322electronic, 2045-2322linking), 2017 Dec 6; 7(1): 17098-17098.
Impact Factor: 5.078
Dettagli    Esporta in BibTeX    Esporta in EndNote

* The double faced role of copper in Ab homeostasis: A survey on the interrelationship between metal dyshomeostasis, UPS functioning and autophagy in neurodegeneration (92 visite)
Grasso G, Santoro AM, Lanza V, Sbardella D, Tundo GR, Ciaccio C, Marini S, Coletta M, Milardi D
Coordination Chemistry Reviews, 2017 Jun; N/D: 1-22.
Impact Factor: 13.324
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Copper(II) ions affect the gating dynamics of the 20S proteasome: a molecular and in cell study (113 visite)
Santoro AM, Monaco I, Attanasio F, Lanza V, Pappalardo G, Tomasello MF, Cunsolo A, Rizzarelli E, De Luigi A, Salmona M, Milardi D
Sci Rep (ISSN: 2045-2322electronic, 2045-2322linking), 2016 Sep 16; 6: 33444-33444.
Impact Factor: 4.259
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Cationic porphyrins are tunable gatekeepers of the 20S proteasome (473 visite) (PDF 145 visite)
Santoro AM, Cunsolo A, D'Urso A, Sbardella D, Tundo GR, Ciaccio C, Coletta M, Diana D, Fattorusso R, Persico M, Di Dato A, Fattorusso C, Milardi D, Purrello R
Chem Sci (ISSN: 2041-6539, 2041-6520, 2041-6520linking), 2016; 7(2): 1286-1297.
Impact Factor: 8.668
Dettagli    Esporta in BibTeX    Esporta in EndNote

* The Inorganic Perspective of VEGF: Interactions of Cu2 + with Peptides Encompassing a Recognition Domain of the VEGF Receptor (143 visite)
Grasso G, Santoro AM, Magrì A, La Mendola D, Tomasello MF, Zimbone S, Rizzarelli E
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2016; 159: 149-158.
Impact Factor: 3.348
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Cationic porphyrins are reversible proteasome inhibitors (154 visite)
Santoro AM, Lo Giudice MC, D'Urso A, Lauceri R, Purrello R, Milardi D
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2012 Jun 27; 134(25): 10451-10457.
Impact Factor: 10.677
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Copper(II) interaction with peptide fragments of histidine-proline-rich glycoprotein: Speciation, stability and binding details (119 visite)
La Mendola D, Magrì A, Santoro AM, Nicoletti VG, Rizzarelli E
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2012 Jun; 111: 59-69.
Impact Factor: 3.197
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Surface adsorption of fibronectin-derived peptide fragments: The influence of electrostatics and hydrophobicity for endothelial cells adhesion (106 visite)
Satriano C, Fragalà ME, Forte G, Santoro AM, La Mendola D, Kasemo B
Soft Matter (ISSN: 1744-683x), 2012; 8(1): 53-56.
Impact Factor: 3.909
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Carnosine interaction with nitric oxide and astroglial cell protection (251 visite)
Nicoletti VG, Santoro AM, Grasso G, Vagliasindi LI, Giuffrida ML, Cuppari C, Purrello VS, Stella AMG, Rizzarelli E
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Sep 1; 85(10): 2239-2245.
Impact Factor: 3.268
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Nitrogen oxide interaction with copper complexes formed by small peptides belonging to the prion protein octa-repeat region (145 visite)
Bonomo RP, Pappalardo G, Rizzarelli E, Santoro AM, Tabbì G, Vagliasindi LI
Dalton Trans (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2007 Apr 14; (14): 1400-1408.
Impact Factor: 3.212
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Protective effect of carnosine during nitrosative stress in astroglial cell cultures (108 visite)
Calabrese V, Colombrita C, Guagliano E, Sapienza M, Ravagna A, Cardile V, Scapagnini G, Santoro AM, Mangiameli A, Butterfield DA, Giuffrida Stella AM, Rizzarelli E
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2005 Jun; 30(6-7): 797-807.
Impact Factor: 2.187
Dettagli    Esporta in BibTeX    Esporta in EndNote

* A re-investigation of copper coordination in the octa-repeats region of the prion protein (118 visite)
Bonomo RP, Cucinotta V, Giuffrida A, Impellizzeri G, Magrì A, Pappalardo G, Rizzarelli E, Santoro AM, Tabbì G, Vagliasindi LI
Dalton Trans (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2005 Jan 7; (1): 150-158.
Impact Factor: 3.003
Dettagli    Esporta in BibTeX    Esporta in EndNote

* A Spectroscopic Investigation Of The Interaction Between Nitrogen Monoxide And Copper Sites Of The Fungal Laccase From Rigidoporus Lignosus (75 visite)
Bonomo RP, Castronovo BM, Santoro AM
Dalton Trans, 2004 Jan 7; N/D: 104-112.
Impact Factor: 4.097
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Structural and kinetic characterization of native laccases from Pleurotas ostreatus, Rigidoporus lignosus, and Trametes trogii (111 visite)
Garzillo AM, Colao MC, Buonocore V, Oliva R, Falcigno L, Saviano M, Santoro AM, Zappala R, Bonomo RP, Bianco C, Giardina P, Palmieri G, Sannia G
Journal Of Protein Chemistry (ISSN: 0277-8033), 2001 Apr; 20(3): 191-201.
Impact Factor: 1.021
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Comparison Of Three Fungal Laccases From Rigidoporus Lignosus And Pleurotus Ostreatus: Correlation Between Conformation Changes And Catalytic Activity (98 visite)
Bonomo RP, Cennamo G, Purrello R, Santoro AM, Zappala R
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2001 Jan 1; 83(1): 67-75.
Impact Factor: 1.729
Dettagli    Esporta in BibTeX    Esporta in EndNote

A comparative study of two isoforms of laccase secreted by the 'white- rot' fungus Rigidoporus lignosus, exhibiting significant structural and functional differences (115 visite)
Bonomo RP, Boudet AM, Cozzolino R, Rizzarelli E, Santoro AM, Sterjiades R, Zappalà R
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1998 Sep; 71(3-4): 205-211.
Impact Factor: 1.162
Dettagli    Esporta in BibTeX    Esporta in EndNote

Ph Modulation Of Porphyrins Self-Assembly Onto Polylisine (78 visite)
Purrello R, Bellacchio E, Gurrieri S, Lauceri R, Raudino A, Monsù Scolaro L, Santoro AM
Journal Of Physical Chemistry B, 1998; N/D: 8852-8857.
Impact Factor: 0
Dettagli    Esporta in BibTeX    Esporta in EndNote

Synthesis, spectroscopic characterisation, and metal ion interaction of a new α-helical peptide (123 visite)
Impellizzeri G, Pappalardo G, Purrello R, Rizzarelli E, Santoro AM
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 1998; 4(9): 1791-1798.
Impact Factor: 5.153
Dettagli    Esporta in BibTeX    Esporta in EndNote

Copper(II) complexes encapsulated in human red blood cells (120 visite)
Bonomo RP, De Flora A, Rizzarelli E, Santoro AM, Tabbì G, Tonetti M
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1995 Sep; 59(4): 773-784.
Impact Factor: 1.342
Dettagli    Esporta in BibTeX    Esporta in EndNote

Copper Addition Prevents The Inhibitory Effects Of Interleukin 1-Beta On Rat Pancreatic Islets (103 visite)
Vinci C, Caltabiano V, Santoro AM, Rabuazzo AM, Buscema M, Purrello R, Rizzarelli E, Vigneri R, Purrello F
Diabetologia, 1995 Jan; 38(1): 39-45.
Impact Factor: 0
Dettagli    Esporta in BibTeX    Esporta in EndNote

O2 - scavenger properties of copper(II) complexes with diamino-diamide-type ligands (113 visite)
Bonomo RP, Conte E, Marchelli R, Santoro AM, Tabbì G
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1994 Feb 1; 53(2): 127-138.
Impact Factor: 1.342
Dettagli    Esporta in BibTeX    Esporta in EndNote

New platinum(II) complexes of β-cyclodextrin diamine derivatives and their antitumor activity (100 visite)
Cucinotta V, Mangano A, Nobile G, Santoro AM, Vecchio G
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1993 Nov 15; 52(3): 183-190.
Impact Factor: 1.342
Dettagli    Esporta in BibTeX    Esporta in EndNote



23 Records (23 escludendo Abstract e Conferenze).
Impact factor totale: 88.365 (88.365 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 99.448 (99.448 escludendo Abstract e Conferenze).








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