View contact record, Full name: Sonia Di Gaetano
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NomeSonia Di Gaetano
AreaRicerca e Sviluppo
QualificaRicercatore
SedeNapoli-Mezzocannone
IndirizzoVia Mezzocannone 16, 80134 Napoli - Italia
E-maildigaetanunina.it
Telefono ufficio+39 081 2532042
▼    Malattie Neoplastiche
▼    Gadd45 beta and its implication in chronic inflammation
▼    Structural characterization of proteins and enzymes isolated from organisms living under unusual conditions
▼    Characterization of the KCTD protein family: key factors in several biological processes
▼    Characterization of neurotoxic and neuroprotective factors by using computational methodologies
▼    Monoclonal Antibodies for therapeutic and diagnostic applications
▼    Targeted Drug Delivery by integrin avb3 antagonist
▼    Protein aggregation and cytotoxicity: molecular, in vitro and in vivo biological studies
Nessun risultato.
▼    Metals role in angiogenesis
Nessun risultato.
▼    Drug Delivery
Nessun risultato.
▼    Bioactive peptide-membrane assemblies
Nessun risultato.
▼    Metals and small molecules in the regulation of the Ubiquitin Proteasome Pathway
Nessun risultato.
▼    Protein semi-synthesis for biophysical and chemical biology applications
▼    Peptide modulators of the VEGF-dependent angiogenesis
▼    Peptides promoting reverse cholesterol transport
▼    CA IX as target for the development of new anti-tumour drugs
▼    Carbonic Anhydrase family as target for rational drug design
▼    Clinical Oncology
▼    Translational Molecular Imaging in Cancer
▼    Molecular imaging for personalized therapy in oncology
▼    Modeling radiation induced normal tissue effects
▼    Test e validazione di nuove sonde molecolari mediante imaging preclinico.
▼    Synthesis of small molecules, modified peptides and nucleobase-decorated peptides. Nucleic acid and protein binding studies
▼    Segmentazione cerebrale per applicazioni in radiologia oncologica
▼    Altre Malattie
▼    Production and characterization of recombinant enzymes for biochemical and biotechnological applications
▼    Structural characterization of proteins and enzymes isolated from organisms living under unusual conditions
▼    Characterization of neurotoxic and neuroprotective factors by using computational methodologies
▼    Protein aggregation and cytotoxicity: molecular, in vitro and in vivo biological studies
Nessun risultato.
▼    Metals role in angiogenesis
Nessun risultato.
▼    Drug Delivery
Nessun risultato.
▼    Bioactive peptide-membrane assemblies
Nessun risultato.
▼    Protein semi-synthesis for biophysical and chemical biology applications
▼    Peptide modulators of the VEGF-dependent angiogenesis
▼    Peptides promoting reverse cholesterol transport
▼    Comparison of noninvasive cardiac imaging modalities in patients with myocardial infarction
▼    Structural and functional studies of virulence factors in Mycobacterium tuberculosis infection
▼    Assessment of the cardiac risk and its temporal variation
▼    Carbonic Anhydrase family as target for rational drug design
▼    Test e validazione di nuove sonde molecolari mediante imaging preclinico.
▼    Synthesis of small molecules, modified peptides and nucleobase-decorated peptides. Nucleic acid and protein binding studies
▼    Fenotipizzazione di modelli murini mediante imaging preclinico.
▼    Characterization of the KCTD protein family: key factors in several biological processes
▼    Peptide modulators of the VEGF-dependent angiogenesis

Born in Rome on 4th September 1968. 1994, February: Degree in Biological Sciences at the University of Rome "La Sapienza". 1994-95: Post-lauream training at the University of Rome "La Sapienza", Dept. of Cellular Biology and Development. 1995, July: On a fellowship at the University of Rome "La Sapienza", Dept. of Cellular Biology and Development. 1995-99: On a fellowship for a PhD in Biochemistry and Molecular Biology, at University of Naples "Federico II". 2000: Contract at the National Council of Research (Center of Biocrystallography), Naples. 2001: Researcher at the C. N. R., Biostructure and Bioimaging Institute, Naples. The research activities of Dr. Di Gaetano have been focused in the fields of molecular biology, cellular biology and biological chemistry. More recently she was interested in the design and functional characterization of oligonucleotide analogs. She was the project leader of a project funded by regional institutions entitled In vitro and in vivo production of the recombinant amyloidogenic protein ApoA-1 (1-93) by adenoviral expression vectors; analysis of fibrils formation mechanism. She participates (or has participated) in several MIUR projects.


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Bibliografia
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* Molecular insights into the role of the polyalanine region in mediating PHOX2B aggregation (0 visite)
Pirone L, Caldinelli L, Di Lascio S, Di Girolamo R, Di Gaetano S, Fornasari D, Pollegioni L, Benfante R, Pedone E
Febs J (ISSN: 1742-464xlinking), 2019 Apr 7; N/D: N/D-N/D.
Impact Factor:
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* Focusing on the functional characterization of the anserinase from Oreochromis niloticus (3 visite)
Pirone L, Di Gaetano S, Rizzarelli E, Bellia F, Pedone E
Int J Biol Macromol (ISSN: 0141-8130linking, 1879-0003electronic), 2019 Feb 22; 130: 158-165.
Impact Factor: 1.427
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* The essential player in adipogenesis GRP78 is a novel KCTD15 interactor (11 visite)
Smaldone G, Pirone L, Capolupo A, Vitagliano L, Monti MC, Di Gaetano S, Pedone E
Int J Biol Macromol (ISSN: 1879-0003electronic, 0141-8130linking), 2018 Aug; 115: 469-475.
Impact Factor: 1.427
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* VEGFR Recognition Interface of a Proangiogenic VEGF-Mimetic Peptide Determined In Vitro and in the Presence of Endothelial Cells by NMR Spectroscopy (10 visite)
Di Stasi R, Diana D, Capasso D, Di Gaetano S, De Rosa L, Celentano V, Isernia C, Fattorusso R, D'Andrea LD
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2018; 24(44): 11461-11466.
Impact Factor: 5.16
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* Chemical Modification for Proteolytic Stabilization of the Selective alphavbeta3 Integrin RGDechi Peptide: in Vitro and in Vivo Activities on Malignant Melanoma Cells (337 visite) (PDF 82 visite)
Comegna D, Zannetti A, Del Gatto A, De Paola I, Russo L, Di Gaetano S, Liguoro A, Capasso D, Saviano M, Zaccaro L
J MED CHEM (ISSN: 0022-2623), 2017 Dec 14; 60(23): 9874-9884.
Impact Factor: 6.253
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* Unveiling a VEGF-mimetic peptide sequence in the IQGAP1 protein (68 visite)
Capasso D, Di Gaetano S, Celentano V, Diana D, Festa L, Di Stasi R, De Rosa L, Fattorusso R, D'Andrea LD
MOL BIOSYST (ISSN: 1742-206X), 2017 Jul 25; 13(8): 1619-1629.
Impact Factor: 2.759
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* A new cryptic host defense peptide identified in human 11-hydroxysteroid dehydrogenase-1 beta-like: from in silico identification to experimental evidence (109 visite)
Bosso A, Pirone L, Gaglione R, Pane K, Del Gatto A, Zaccaro L, Di Gaetano S, Diana D, Fattorusso R, Pedone E, Cafaro V, Haagsman HP, Van Dijk A, Scheenstra MR, Zanfardino A, Crescenzi O, Arciello A, Varcamonti M, Veldhuizen EJA, Di Donato A, Notomista E, Pizzo E
BBA-BIOENERGETICS (ISSN: 0005-2728), 2017 Apr 25; N/D: N/D-N/D.
Impact Factor: 4.28
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* Benzodifuran derivatives as potential antiproliferative agents: possible correlation between the bioactivity and their aggregation properties (145 visite)
Musumeci D, Roviello GN, Rigione G, Capasso D, Di Gaetano S, Riccardi C, Roviello V, Montesarchio D
Chempluschem, 2017; 82: 251-260.
Impact Factor: 2.8
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* Proteins involved in sleep homeostasis: Biophysical characterization of INC and its partners (104 visite) (PDF 98 visite)
Pirone L, Smaldone G, Esposito C, Balasco N, Petoukhov MV, Spilotros A, Svergun DI, Di Gaetano S, Vitagliano L, Pedone E
BIOCHIMIE (ISSN: 0300-9084), 2016 Sep 24; N/D: N/D-N/D.
Impact Factor: 3.112
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* Regulating levels of the neuromodulator d-serine in human brain: structural insight into pLG72 and d-amino acid oxidase interaction (76 visite) (PDF 113 visite)
Birolo L, Sacchi S, Smaldone G, Molla G, Leo G, Caldinelli L, Pirone L, Eliometri P, Di Gaetano S, Orefice I, Pedone E, Pucci P, Pollegioni L
FEBS J (ISSN: 1742-464X), 2016 Sep; 283(18): 3353-3370.
Impact Factor: 3.902
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* A Combined NMR and Computational Approach to Determine the RGDechi-hCit-alphav beta3 Integrin Recognition Mode in Isolated Cell Membranes (100 visite)
Farina B, De Paola I, Russo L, Capasso D, Liguoro A, Gatto AD, Saviano M, Pedone PV, Di Gaetano S, Malgieri G, Zaccaro L, Fattorusso R
CHEM-EUR J (ISSN: 0947-6539), 2016 Jan 11; 22(2): 681-693.
Impact Factor: 5.317
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* A new cryptic cationic antimicrobial peptide from human apolipoprotein E with antibacterial activity and immunomodulatory effects on human cells (135 visite)
Pane K, Sgambati V, Zanfardino A, Smaldone G, Cafaro V, Angrisano T, Pedone E, Di Gaetano S, Capasso D, Haney EF, Izzo V, Varcamonti M, Notomista E, Hancock RE, Di Donato A, Pizzo E
FEBS J (ISSN: 1742-464X), 2016; N/D: N/D-N/D.
Impact Factor: 3.902
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* Solid phase synthesis and RNA-binding activity of an arginine-containing nucleopeptide (121 visite)
Roviello GN, Vicidomini C, Di Gaetano S, Capasso D, Musumeci D, Roviello V
RSC ADV (ISSN: 2046-2069), 2016; 6(17): 14140-14148.
Impact Factor: 3.108
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* Cullin 3 recognition is not a universal property among KCTD proteins (143 visite)
Smaldone G, Pirone L, Balasco N, Di Gaetano S, Pedone E, Vitagliano L
PLOS ONE (ISSN: 1932-6203), 2015 May 14; 10(5): e0126808-e0126808.
Impact Factor: 3.057
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* Cullin3 - BTB interface: A novel target for stapled peptides (193 visite)
De Paola I, Pirone L, Palmieri M, Balasco N, Esposito L, Russo L, Mazza D, Di Marcotullio L, Di Gaetano S, Malgieri G, Vitagliano L, Pedone E, Zaccaro L
PLOS ONE (ISSN: 1932-6203), 2015 Apr 7; 10(4): e0121149-e0121149.
Impact Factor: 3.057
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* Insight into conformational modification of alpha-synuclein in the presence of neuronal whole cells and of their isolated membranes (135 visite)
Smaldone G, Diana D, Pollegioni L, Di Gaetano S, Fattorusso R, Pedone E
FEBS LETT (ISSN: 0014-5793), 2015 Feb 18; 589(7): 798-804.
Impact Factor: 3.519
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* Functional Binding Surface Of A Beta-Hairpin Vegf Receptor Targeting Peptide Determined By Nmr Spectroscopy In Living Cells (147 visite)
Diana D, Russomanno A, De Rosa L, Di Stasi R, Capasso D, Di Gaetano S, Romanelli A, Russo L, D'Andrea LD, Fattorusso R
CHEM-EUR J (ISSN: 0947-6539), 2015 Jan 2; 21(1): 91-95.
Impact Factor: 5.771
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* Rgdechi-Hcit: Alpha V Beta 3 Selective Pro-Apoptotic Peptide As Potential Carrier For Drug Delivery Into Melanoma Metastatic Cells (132 visite)
Capasso D, De Paola I, Liguoro A, Del Gatto A, Di Gaetano S, Guarnieri D, Saviano M, Zaccaro L
PLOS ONE (ISSN: 1932-6203), 2014 Sep 23; 9(9): e106441-e106441.
Impact Factor: 3.234
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* Molecular recognition of Cullin3 by KCTDs: Insights from experimental and computational investigations (120 visite)
Balasco N, Pirone L, Smaldone G, Di Gaetano S, Esposito L, Pedone E, Vitagliano L
BBA-MOL BASIS DIS (ISSN: 0925-4439), 2014 Jul; 1844(7): 1289-1298.
Impact Factor: 4.882
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* Synthesis and supramolecular assembly of 1, 3-bis(1 '-uracilyl)-2-propanone (133 visite)
Roviello GN, Roviello GN, Musumeci D, Capasso D, Di Gaetano S, Costanzo M, Pedone C
RSC ADV (ISSN: 2046-2069), 2014; 4(54): 28691-28698.
Impact Factor: 3.84
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* A biophysical characterization of the folded domains of KCTD12: insights into interaction with the GABA(B2) receptor (115 visite)
Correale S, Esposito C, Pirone L, Vitagliano L, Di Gaetano S, Pedone E
Journal Of Molecular Recognition (ISSN: 0952-3499, 0952-2349), 2013 Oct; 26(10): 488-495.
Impact Factor: 2.337
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* Mapping Functional Interaction Sites of Human Prune C-Terminal Domain by NMR Spectroscopy in Human Cell Lysates (138 visite)
Diana D, Smaldone G, De Antonellis P, Pirone L, Carotenuto M, Alonzi A, Di Gaetano S, Zollo M, Pedone E, Fattorusso R
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2013 Sep 9; 19(37): 12217-12220.
Impact Factor: 5.696
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* gH625 is a viral derived peptide for effective delivery of intrinsically disordered proteins (148 visite)
Smaldone G, Falanga A, Capasso D, Guarnieri D, Correale S, Galdiero M, Netti PA, Zollo M, Galdiero S, Di Gaetano S, Pedone E
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1178-2013electronic), 2013; 8: 2555-2565.
Impact Factor: 4.195
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* Thermal and chemical stability of two homologous POZ/BTB domains of KCTD proteins characterized by a different oligomeric organization (136 visite)
Pirone L, Esposito C, Correale S, Graziano G, Di Gaetano S, Vitagliano L, Pedone E
Biomed Res Int (ISSN: 2314-6133, 2314-6141, 2314-6141electronic), 2013; 2013: 162674-162674.
Impact Factor: 1.579
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* Functional and pharmacological characterization of a VEGF mimetic peptide on reparative angiogenesis (169 visite)
Finetti F, Basile A, Capasso D, Di Gaetano S, Di Stasi R, Pascale M, Turco CM, Ziche M, Morbidelli L, D'Andrea LD
Biochem Pharmacol Biochemical Pharmacology (ISSN: 0006-2952, 1873-2968), 2012 Sep 1; 84(3): 303-311.
Impact Factor: 4.576
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* Gamma Sulphate Pna (pna S): Highly Selective Dna Binding Molecule Showing Promising Antigene Activity (127 visite)
Avitabile C, Moggio L, Malgieri G, Capasso D, Di Gaetano S, Saviano M, Pedone C, Romanelli A
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2012 May 7; 7(5): e35774-e35774.
Impact Factor: 3.73
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* Apolipoprotein A-I amyloidogenic variant L174S, expressed and isolated from stably transfected mammalian cells, is associated with fatty acids (93 visite)
Monti DM(1), Di Gaetano S, Del Giudice R, Giangrande C, Amoresano A, Monti M, Arciello A, Piccoli R
Amyloid (ISSN: 1350-6129), 2012 Mar; 19(1): 21-27.
Impact Factor: 4.436
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* A straightforward synthetic access to symmetrical glycosyl disulfides and biological evaluation thereof (112 visite)
Adinolfi M, Capasso D, Di Gaetano S, Iadonisi A, Leone L, Pastore A
Org Biomol Chem (ISSN: 1477-0520, 1477-0539, 1477-0539electronic), 2011 Sep 21; 9(18): 6278-6283.
Impact Factor: 3.696
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* Design, synthesis and characterization of a peptide able to bind proteins of the KCTD family: implications for KCTD - cullin 3 recognition (121 visite)
Pirone L, Correale S, De Paola I, Zaccaro L, De Simone G, Vitagliano L, Pedone E, Di Gaetano S
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 May; 17(5): 373-376.
Impact Factor: 1.799
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* RNA-binding and viral reverse transcriptase inhibitory activity of a novel cationic diamino acid-based peptide (118 visite)
Roviello GN, Di Gaetano S, Capasso D, Franco S, Crescenzo C, Bucci EM, Pedone C
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2011 Apr 14; 54(7): 2095-2101.
Impact Factor: 5.248
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* Effects of the Known Pathogenic Mutations on the Aggregation Pathway of the Amyloidogenic Peptide of Apolipoprotein A-I (139 visite)
Raimondi S, Guglielmi F, Giorgetti S, Di Gaetano S, Arciello A, Monti DM, Relini A, Nichino D, Doglia SM, Natalello A, Pucci P, Mangione P, Obici L, Merlini G, Stoppini M, Robustelli P, Tartaglia GG, Vendruscolo M, Dobson CM, Piccoli R, Bellotti V
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2011 Apr 1; 407(3): 465-476.
Impact Factor: 4.001
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* Molecular organization of the cullin E3 ligase adaptor KCTD11 (145 visite)
Correale S, Pirone L, Di Marcotullio L, De Smaele E, Greco A, Mazzà D, Moretti M, Alterio V, Vitagliano L, Di Gaetano S, Gulino A, Pedone E
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2011 Apr; 93(4): 715-724.
Impact Factor: 3.022
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* Synthesis of a novel Fmoc-protected nucleoaminoacid for the solid phase assembly of 4-piperidyl glycine/L-arginine-containing nucleopeptides and preliminary RNA interaction studies (134 visite)
Roviello GN, Crescenzo C, Capasso D, Di Gaetano S, Franco S, Bucci EM, Pedone C
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 Sep; 39(3): 795-800.
Impact Factor: 4.106
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* Synthesis, spectroscopic studies and biological activity of a novel nucleopeptide with Moloney murine leukemia virus reverse transcriptase inhibitory activity (131 visite)
Roviello GN, Di Gaetano S, Capasso D, Cesarani A, Bucci EM, Pedone C
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 May; 38(5): 1489-1496.
Impact Factor: 4.106
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* Alternate dab-aegPNAs: synthesis, nucleic acid binding studies and biological activity (150 visite)
Roviello GN, Musumeci D, De Cristofaro A, Capasso D, Di Gaetano S, Bucci EM, Pedone C
Mol Biosyst (ISSN: 1742-2051, 1742-206x, 1742-2051electronic), 2010 Jan; 6(1): 199-205.
Impact Factor: 3.825
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* Structural features for the mechanism of antitumor action of a dimeric human pancreatic ribonuclease variant (92 visite)
Merlino A, Avella G, Di Gaetano S, Arciello A, Piccoli R, Mazzarella L, Sica F
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic, 0961-8368linking), 2009 Jan; 18(1): 50-57.
Impact Factor: 2.937
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* Recombinant amyloidogenic domain of ApoA-I: analysis of its fibrillogenic potential (122 visite)
Di Gaetano S, Guglielmi F, Arciello A, Mangione P, Monti M, Pagnozzi D, Raimondi S, Giorgetti S, Orru S, Canale C, Pucci P, Dobson CM, Bellotti V, Piccoli R
Biochemical And Biophysical Research Communications (ISSN: 0006-291x, 0006-291xprint), 2006 Dec 8; 351(1): 223-228.
Impact Factor: 2.855
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* Antineoplastic ribonucleases selectively kill thyroid carcinoma cells via caspase-mediated induction of apoptosis (121 visite)
Spalletti-cernia D, Sorrentino R, Di Gaetano S, Arciello A, Garbi C, Piccoli R, D'Alessio G, Vecchio G, Laccetti P, Santoro M
Journal Of Clinical Endocrinology & Metabolism (ISSN: 0021-972x), 2003 Jun; 88(6): 2900-2907.
Impact Factor: 5.873
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38 Records (36 escludendo Abstract e Conferenze).
Impact factor totale: 138.824 (131.86 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 136.041 (128.095 escludendo Abstract e Conferenze).