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NomeLuciana Esposito
AreaRicerca e Sviluppo
QualificaRicercatore
SedeNapoli - Mezzocannone
IndirizzoVia Mezzocannone 16, 80134 Napoli - Italia
E-mailluciana.espositocnr.it
Telefono ufficio+39 081 2536614

July 1995: Chemistry Degree (summa cum laude), at the University of Naples Federico II presenting a thesis which received the "G. Laonigro" award from the Italian Chemical Society. 1995-1998: Ph. D. in Protein Crystallography, Department of Chemistry, University of Naples Federico II. 1998-1999: Temporary Fellow at the CNR Biocrystallography Research Center-Naples". 2003: Short-term fellowship award from the International Human Frontier Science Program Organization. June-Oct. 2003: Visiting scientist at the University of Washington, Seattle, USA. May 2010: Visiting scientist at the University of Cambridge, UK. Since Dec. 2001: Permanent staff scientist at the CNR-IBB. My scientific interests lie in the general area of Structural Biology with an emphasis on computational techniques applied to the study of macromolecular systems. Indeed, my expertise in experimental macromolecular crystallography has been complemented by theoretical approaches such as statistical analyses on structural databases, molecular modeling, and molecular dynamics (MD) simulations. The main results of my research activities have been achieved in the following fields: (i) the study of the deamidation process and its structural effects in proteins (ii) protein crystallization in microgravity conditions (iii) ultra-high resolution protein structural studies (iv) structural studies of extremophilic dehydrogenases (v) statistical analyses of databases to unveil novel details and properties of protein structures (vi) MD study of the dynamical behaviour of proteins and/or polypeptide fragments involved in the misfolding process, eventually leading to amyloid fiber formation (vii) the study of disease-causing mutations in human proteins.



Contiene: [X]      Estesa  

Autori: [X]   E Tipo di lavoro: [X]

E Data iniziale: Data finale: [X]   E Sede:  E    Affiliazione IBB   [Pulisci modulo]

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* Multiple Electronic and Structural Factors Control Cyclobutane Pyrimidine Dimer and 6-4 Thymine-Thymine Photodimerization in a DNA Duplex (23 visite)
Conti I, Martinez-fernandez L, Esposito L, Hofinger S, Nenov A, Garavelli M, Improta R
Chemistry (ISSN: 1521-3765electronic, 0947-6539linking), 2017 Oct 26; 23(60): 15177-15188.
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* Factors affecting the amplitude of the tau angle in proteins: a revisitation (33 visite)
Balasco N, Esposito L, Vitagliano L
Acta Crystallogr D Struct Biol (ISSN: 2059-7983electronic, 2059-7983linking), 2017 Jul 01; 73(Pt7): 618-625.
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* UV-induced damage to DNA: effect of cytosine methylation on pyrimidine dimerization (25 visite)
Martinez-fernandez L, Banyasz A, Esposito L, Markovitsi D, Improta R
Signal Transduction And Targeted Therapy, 2017 Jun; N/D: N/D-N/D.
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* Dissection of Factors Affecting the Variability of the Peptide Bond Geometry and Planarity (15 visite)
Balasco N, Esposito L, Thind AS, Guarracino MR, Vitagliano L
Biomed Res Int (ISSN: 2314-6141electronic), 2017; 2017: 2617629-2617629.
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* Excited State Pathways Leading to Formation of Adenine Dimers (48 visite)
Banyasz A, Martinez-fernandez L, Ketola TM, Munoz-losa A, Esposito L, Markovitsi D, Improta R
J Phys Chem Lett (ISSN: 1948-7185electronic, 1948-7185linking), 2016 Jun 2; 7(11): 2020-2023.
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* Effect of C5-Methylation of Cytosine on the UV-Induced Reactivity of Duplex DNA: Conformational and Electronic Factors (59 visite)
Banyasz A, Esposito L, Douki T, Perron M, Lepori C, Improta R, Markovitsi D
J Phys Chem B (ISSN: 1520-5207electronic, 1520-5207linking, 1520-6106), 2016 May 12; 120(18): 4232-4242.
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* The determinants of bond angle variability in protein/peptide backbones: A comprehensive statistical/quantum mechanics analysis (32 visite)
Improta R, Vitagliano L, Esposito L
Proteins (ISSN: 1097-0134electronic, 0887-3585linking), 2015 Nov; 83(11): 1973-1986.
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* Cullin3 - BTB interface: A novel target for stapled peptides (137 visite)
De Paola I, Pirone L, Palmieri M, Balasco N, Esposito L, Russo L, Mazza D, Di Marcotullio L, Di Gaetano S, Malgieri G, Vitagliano L, Pedone E, Zaccaro L
Plos One (ISSN: 1932-6203, 1932-6203electronic), 2015 Apr 7; 10(4): e0121149-e0121149.
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* Bond distances in polypeptide backbones depend on the local conformation (71 visite)
Improta R, Vitagliano L, Esposito L
Acta Crystallogr Sect D Biol Crystallogr Acta Crystallographica Section D Biological Crystallography (ISSN: 0907-4449), 2015; 71: 1272-1283.
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* Effect of C5-methylation of cytosine on the photoreactivity of DNA: A joint experimental and computational study of TCG trinucleotides (81 visite)
Esposito L, Banyasz A, Douki T, Perron M, Markovitsi D, Improta R
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2014 Sep 6; 136(31): 10838-10841.
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* Molecular recognition of Cullin3 by KCTDs: Insights from experimental and computational investigations (90 visite)
Balasco N, Pirone L, Smaldone G, Di Gaetano S, Esposito L, Pedone E, Vitagliano L
Biochim Biophys Acta (ISSN: 1570-9639, 0006-3002, 0925-4439), 2014 Jul; 1844(7): 1289-1298.
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* Role of loops connecting secondary structure elements in the stabilization of proteins isolated from thermophilic organisms (74 visite)
Balasco N, Esposito L, De Simone A, Vitagliano L
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 2013 Jul; 22(7): 1016-1023.
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* The Intrinsic Stability Of The Human Prion Beta-Sheet Region Investigated By Molecular Dynamics (125 visite)
De Simonea A, Stanzione F, Marasco D, Vitagliano L, Esposito L
Journal Of Biomolecular Structure & Dynamics, 2013 May 1; 31(5): 441-452.
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* FOR the RECORD: Role of loops connecting secondary structure elements in the stabilization of proteins isolated from thermophilic organisms (84 visite)
Balasco N, Esposito L, De Simone A, Vitagliano L
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 2013; 22(7): 1016-1023.
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* Interplay between peptide bond geometrical parameters in nonglobular structural contexts (85 visite)
Esposito L, Balasco N, De Simone A, Berisio R, Vitagliano L
Biomed Res Int (ISSN: 2314-6133, 2314-6141, 2314-6141electronic), 2013; 2013: N/D-N/D.
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* Crystallographic and spectroscopic characterizations of Sulfolobus solfataricus TrxA1 provide insights into the determinants of thioredoxin fold stability (85 visite)
Esposito L, Ruggiero A, Masullo M, Ruocco MR, Lamberti A, Arcari P, Zagari A, Vitagliano L
Journal Of Structural Biology (ISSN: 1047-8477), 2012 Feb; 177(2): 506-512.
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* Peptide bond distortions from planarity: New insights from quantum mechanical calculations and peptide/protein crystal structures (96 visite)
Improta R, Vitagliano L, Esposito L
Plos One (ISSN: 1932-6203, 1932-6203electronic), 2011 Sep 16; 6(9): e24533-e24533.
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* Role of the conformational versatility of the neurotrophin N-terminal regions in their recognition by Trk receptors (80 visite)
Stanzione F, Esposito L, Paladino A, Pedone C, Morelli G, Vitagliano L
Biophysical Journal (ISSN: 1542-0086, 0006-3495), 2010 Oct 6; 99(7): 2273-2278.
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* Probing The Peptidylglycine Alpha-Hydroxylating Monooxygenase Active Site With Novel 4-Phenyl-3-Butenoic Acid Based Inhibitors (123 visite)
Langella E, Pierre S, Ghattas W, Giorgi M, Réglier M, Saviano M, Esposito L, Hardré R
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2010 Sep 3; 5(9): 1568-1576.
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* Functional analysis of melanocortin-4-receptor mutants identified in severely obese subjects living in Southern Italy (83 visite)
Alfieri A, Pasanisi F, Salzano S, Esposito L, Martone D, Tafuri D, Daniele A, Contaldo F, Sacchetti L, Zagari A, Buono P
Gene (ISSN: 0378-1119), 2010 Jun 1; 457(1-2): 35-41.
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* Insight into the stereospecificity of short-chain Thermus thermophilus alcohol dehydrogenase showing pro-S hydride transfer and Prelog enantioselectivity (102 visite)
Pennacchio A, Giordano A, Esposito L, Langella E, Rossi M, Raia CA
Protein And Peptide Letters (ISSN: 0929-8665, 1875-5305), 2010 Apr; 17(4): 437-443.
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* Nonsynonimous mutation of catechol-O-methyl-transferase (COMT) gene in a patient with temporomandibular disorder (101 visite)
D'Antò V, Michelotti A, Esposito L, Zagari A, Liguori R, Sacchetti L
Progress In Orthodontics, 2010; 11: 174-179.
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* Dynamics and Stability of Amyloid-Like Steric Zipper Assemblies with Hydrophobic Dry Interfaces (87 visite)
Vitagliano L, Stanzione F, De Simone A, Esposito L
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2009 Dec; 91(12): 1161-1171.
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* Role of Tryptophan 95 in substrate specificity and structural stability of Sulfolobus solfataricus alcohol dehydrogenase (78 visite)
Pennacchio A, Esposito L, Zagari A, Rossi M, Raia CA
Extremophilesextremophiles (ISSN: 1431-0651, 1433-4909), 2009 Sep; 13(5): 751-761.
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* Functional and structural characterization of novel mutations and genotype-phenotype correlation in 51 phenylalanine hydroxylase deficient families from Southern Italy (75 visite)
Daniele A, Scala I, Cardillo G, Pennino C, Ungaro C, Sibilio M, Parenti G, Esposito L, Zagari A, Andria G, Salvatore F
Febs Journal (ISSN: 1742-464x), 2009 Apr; 276(7): 2048-2059.
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* Stability of single sheet GNNQQNY aggregates analyzed by replica exchange molecular dynamics: antiparallel versus parallel association (103 visite)
Vitagliano L, Esposito L, Pedone C, De Simone A
Biochem Biophys Res Commun (ISSN: 1090-2104, 0006-291x, 1090-2104electronic), 2008 Dec 26; 377(4): 1036-1041.
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* The crystal structure of the superoxide dismutase from Helicobacter pylori reveals a structured C-terminal extension (76 visite)
Esposito L, Seydel A, Aiello R, Sorrentino G, Cendron L, Zanotti G, Zagari
Biochim Biophys Acta (ISSN: 1570-9639, 0006-3002, 0925-4439), 2008 Nov; 1784(11): 1601-1606.
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* Insights into stability and toxicity of amyloid-like oligomers by replica exchange molecular dynamics analyses (84 visite)
De Simone A, Esposito L, Pedone C, Vitagliano L
Biophysical Journal (ISSN: 1542-0086, 0006-3495), 2008 Sep 15; 95(4): 1965-1973.
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* Five human phenylalanine hydroxylase proteins identified in mild hyperphenylalaninemia patients are disease-causing variants (73 visite)
Daniele A, Cardillo G, Pennino C, Carbone MT, Scognamiglio D, Esposito L, Correra A, Castaldo G, Zagari A, Salvatore F
Biochim Biophys Acta (ISSN: 0925-4439, 0006-3002, 1570-9639), 2008 Jun; 1782(6): 378-384.
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* Insights into structure, stability, and toxicity of monomeric and aggregated polyglutamine models from molecular dynamics simulations (78 visite)
Esposito L, Paladino A, Pedone C, Vitagliano L
Biophysical Journal (ISSN: 1542-0086, 0006-3495), 2008 May 15; 94(10): 4031-4040.
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* Molecular dynamics analyses of cross-beta-spine steric zipper models: beta-sheet twisting and aggregation (109 visite)
Esposito L, Pedone C, Vitagliano L
Proc Natl Acad Sci U S A (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2006 Sep 1; 103(31): 11533-11538.
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* Polyglutamine Repeats And Beta-Helix Structure: Molecular Dynamics Study (95 visite)
Merlino A, Esposito L, Vitagliano L
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Jun 1; 63(4): 918-927.
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* Correlation Between Omega And Psi Dihedral Angles In Protein Structures (66 visite)
Esposito L, De Simone A, Zagari A, Vitagliano L
J Mol Biol Journal Of Molecular Biology (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2005 Apr 1; 347(3): 483-487.
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* Insight into ribonuclease A domain swapping by molecular dynamics unfolding simulations (72 visite)
Esposito L, Daggett V
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2005 Mar 8; 44(9): 3358-3368.
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* Crystal structure of a ternary complex of the alcohol dehydrogenase from Sulfolobus solfataricus (90 visite)
Esposito L, Bruno I, Sica F, Raia CA, Giordano A, Rossi M, Mazzarella L, Zagari A
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2003 Dec 16; 42(49): 14397-14407.
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* Structural study of a single-point mutant of Sulfolobus solfataricus alcohol dehydrogenase with enhanced activity (76 visite)
Esposito L, Bruno I, Sica F, Raia CA, Giordano A, Rossi M, Mazzarella L, Zagari A
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2003 Mar 27; 539(1-3): 14-18.
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* Crystal Structure Of The Alcohol Dehydrogenase From The Hyperthermophilic Archaeon Sulfolobus Solfataricus At 1. 85 Angstrom Resolution (85 visite)
Esposito L, Sica F, Raia CA, Giordano A, Rossi M, Mazzarella L, Zagari A
J Mol Biol Journal Of Molecular Biology (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2002 Apr 26; 318(2): 463-477.
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* Recent advances in atomic resolution protein crystallography (70 visite)
Esposito L, Vitagliano L, Mazzarella L
Protein And Peptide Letters (ISSN: 0929-8665, 1875-5305), 2002 Apr; 9(2): 95-105.
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Effect of deamidation on folding of ribonuclease (53 visite)
Orru S, Vitagliano L, Esposito L, Mazzarella L, Marino G, Ruoppolo M
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 2000 Dec; 9(12): 2577-2582.
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Experimental evidence for the correlation of bond distances in peptide groups detected in ultrahigh-resolution protein structures (70 visite)
Esposito L, Vitagliano L, Zagari A, Mazzarella L
Protein Eng (ISSN: 0269-2139, 0269-2139print, 0269-2139linking), 2000 Dec; 13(12): 825-828.
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Pyramidalization of backbone carbonyl carbon atoms in proteins (76 visite)
Esposito L, Vitagliano L, Zagari A, Mazzarella L
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 2000 Oct; 9(10): 2038-2042.
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The ultrahigh resolution crystal structure of ribonuclease A containing an isoaspartyl residue: Hydration and sterochemical analysis (121 visite)
Esposito L, Vitagliano L, Sica F, Sorrentino G, Zagari A, Mazzarella L
J Mol Biol Journal Of Molecular Biology (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2000 Mar 31; 297(3): 713-732.
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Protein crystal growth in the advanced protein crystallization facility on the LMS mission: A comparison of Sulfolobus solfataricus alcohol dehydrogenase crystals grown on the ground and in microgravity (74 visite)
Esposito L, Sica F, Sorrentino G, Berisio R, Carotenuto L, Giordano A, Raia CA, Rossi M, Lamzin VS, Wilson KS, Zagari A
Acta Crystallogr Sect D Biol Crystallogr Acta Crystallographica Section D Biological Crystallography (ISSN: 0907-4449), 1998; 54(3): 386-390.
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Deamidation in proteins: The crystal structure of bovine pancreatic ribonuclease with an isoaspartyl residue at position 67 (69 visite)
Capasso S, Di Donato A, Esposito L, Sica F, Sorrentino G, Vitagliano L, Zagari A, Mazzarella L
J Mol Biol Journal Of Molecular Biology (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 1996; 257(3): 492-496.
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44 Records (43 escludendo Abstract e Conferenze).
Impact factor totale: 158.126 (154.034 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 161.116 (156.579 escludendo Abstract e Conferenze).

Interrogazione bibliografica effettuata: ([author] ESPOSITO_L)








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