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NomeAgataGraziella Copani
AreaAssociati
QualificaAssociato
SedeCatania
Indirizzoc/o Dipartimento di Scienze Chimiche Viale Andrea Doria 6, 95125 Catania - Italy
E-mailacopanikatamail.com
Nessuna area di ricerca
Nessuna attivitá
Posizione accademica: Professore di Farmacologia, Dipartimento di
Scienze del Farmaco, Università di Catania. Formazione: 1984 - Maturità
Scientifica (60/60); 1990 - Laurea in Medicina e Chirurgia (110/110 e
Lode); 1991/92-"Postdoctoral researcher" presso il Dipartimento di
Psicobiologia, Università di Irvine, California; 1994 - Specializzazione
in Neurologia (50/50 e Lode); 1999 - Dottorato di Ricerca in
Neurobiologia; 2002 - Specializzazione in Biochimica e Chimica Clinica
(70/70 e Lode). Attività Scientifica: Ricerca in ambito
neurofarmacologico e neurobiologico, con particolare riguardo ai
meccanismi di degenerazione cellulare nella demenza d'Alzheimer.
Co-autrice di 116 articoli recensiti su Pubmed. Scholar H-index = 51.
2004 – ad oggi: Membro associato all’Istituto di Bioimmagini e
Biostrutture del CNR. Comitati Editoriali: Current Medicinal Chemistry,
Frontiers in Experimental Pharmacology and Drug discovery. Società
scientifiche: Società Italiana di Farmacologia e Società Americana di
Neuroscienze.

Contiene: [X]      Estesa         Autori: [X]      Tipo di lavoro: [X]
Data iniziale: Data finale: [X]      Sede: Affiliazione IBB     
    
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Ordina per:   data    titolo    impact factor

* Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system (69 visite)
Di Menna L, Joffe ME, Iacovelli L, Orlando R, Lindsley CW, Mairesse J, Gressèns P, Cannella M, Caraci F, Copani A, Bruno V, Battaglia G, Conn PJ, Nicoletti F
Neuropharm (ISSN: 0028-3908linking, 1873-7064electronic), 2018 Jan; 128: 301-313.
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Metabotropic glutamate receptors: the potential for therapeutic applications in Alzheimer's disease (60 visite)
Caraci F, Nicoletti F, Copani A
Curr Opin Pharmacol (ISSN: 1471-4973electronic, 1471-4892linking), 2017 Dec 23; 38: 1-7.
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Amyloid Beta monomers regulate cyclic adenosine monophosphate response element binding protein functions by activating type-1 insulin-like growth factor receptors in neuronal cells (284 visite) (PDF 92 visite)
Zimbone S, Monaco I, Giani F, Pandini G, Copani AG, Giuffrida ML, Rizzarelli E
Aging Cell (ISSN: 1474-9726electronic, 1474-9718linking), 2017 Nov 01; N/D: N/D-N/D.
Dettagli    Esporta in BibTeX    Esporta in EndNote

* The underexplored question of beta-amyloid monomers (54 visite)
Copani A
Eur J Pharmacol (ISSN: 1879-0712electronic, 0014-2999linking), 2017 May 31; N/D: N/D-N/D.
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Fluoxetine Prevents Ab1-42-Induced Toxicity via a Paracrine Signaling Mediated by Transforming-Growth- Factor-b1 (69 visite) (PDF 104 visite)
Caraci F, Tascedda F, Merlo F, Benatti C, Spampinato S, Munafò A, Leggio GM, Nicoletti F, Brunello N, Drago F, Sortino MA, Copani A
Frontiers In Pharmacology, 2016 Oct; 7: 1-11.
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Ac-LPFFD-Th: A Trehalose-Conjugated Peptidomimetic as a Strong Suppressor of Amyloid-beta Oligomer Formation and Cytotoxicity (107 visite)
Sinopoli A, Giuffrida A, Tomasello MF, Giuffrida ML, Leone M, Attanasio F, Caraci F, De Bona P, Naletova I, Saviano M, Copani A, Pappalardo G, Rizzarelli E
Chembiochem (ISSN: 1439-7633electronic, 1439-4227linking), 2016 Aug 17; 17(16): 1541-1549.
Dettagli    Esporta in BibTeX    Esporta in EndNote

* The impact of metabotropic glutamate receptors into active neurodegenerative processes: A "dark side" in the development of new symptomatic treatments for neurologic and psychiatric disorders (68 visite)
Caraci F, Bruno V, Copani A, Matrisciano F, Nicoletti F, Battaglia G
Neuropharm (ISSN: 1873-7064electronic, 0028-3908linking), 2016 Apr 30; N/D: N/D-N/D.
Dettagli    Esporta in BibTeX    Esporta in EndNote

* The antineoplastic drug flavopiridol reverses memory impairment induced by Amyloid-ss1-42 oligomers in mice (106 visite)
Leggio GM, Catania MV, Puzzo D, Spatuzza M, Pellitteri R, Gulisano W, Torrisi SA, Giurdanella G, Piazza C, Impellizzeri AR, Gozzo L, Navarria A, Bucolo C, Nicoletti F, Palmeri A, Salomone S, Copani A, Caraci F, Drago F
Pharmacol Res (ISSN: 1096-1186electronic, 1043-6618linking), 2016 Apr; 106: 10-20.
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Monomeric ss-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons (169 visite)
Giuffrida ML, Tomasello MF, Pandini G, Caraci F, Battaglia G, Busceti C, Di Pietro P, Pappalardo G, Attanasio F, Chiechio S, Bagnoli S, Nacmias B, Sorbi S, Vigneri R, Rizzarelli E, Nicoletti F, Copani A
Frontiers In Cellular Neuroscience (ISSN: 1662-5102electronic, 1662-5102linking), 2015 Aug 7; 9(AUGUST): 297-297.
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Neuroprotective effects of the monoamine oxidase inhibitor Tranylcypromine and its amide derivatives against Abeta(1-42)-induced toxicity (163 visite)
Caraci F, Pappalardo G, Basile L, Giuffrida A, Copani A, Tosto R, Sinopoli A, Giuffrida ML, Pirrone E, Drago F, Pignatello R, Guccione S
Eur J Pharmacol (ISSN: 1879-0712electronic, 0014-2999linking), 2015 Jul 7; 764: 256-263.
Dettagli    Esporta in BibTeX    Esporta in EndNote

* A ratiometric naphthalimide sensor for live cell imaging of copper(i) (107 visite)
Satriano C, Sfrazzetto GT, Amato ME, Ballistreri FP, Copani A, Giuffrida ML, Grasso G, Pappalardo A, Rizzarelli E, Tomaselli GA, Toscano RM
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2013 Jun 21; 49(49): 5565-5567.
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Insulin has multiple antiamyloidogenic effects on human neuronal cells (121 visite)
Pandini G, Pace V, Copani A, Squatrito S, Milardi D, Vigneri R
Endocrinology (ISSN: 0013-7227, 1945-7170), 2013 Jan; 154(1): 375-387.
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Shared and distinct features of beta-amyloid peptides (114 visite)
Giuffrida M, Caraci F, Tomasello F, Pappalardo G, Rizzarelli E, Nicoletti F, Copani AG
Society For Neuroscience Abstract Viewer And Itinerary Planner, 2013; 43: N/D-N/D.
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Beta-Amyloid monomer and insulin/IGF-1 signaling in Alzheimer's disease (139 visite)
Giuffrida ML, Tomasello F, Caraci F, Chiechio S, Nicoletti F, Copani A
Mol Neurobiol (ISSN: 0893-7648), 2012 Dec; 46(3): 605-613.
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Metabotropic glutamate receptors in neurodegeneration/neuroprotection: Still a hot topic? (147 visite)
Caraci F, Battaglia G, Sortino MA, Spampinato S, Molinaro G, Copani A, Nicoletti F, Bruno V
Neurochem Int (ISSN: 0197-0186), 2012 Sep; 61(4): 559-565.
Dettagli    Esporta in BibTeX    Esporta in EndNote

* DNA polymerase-β mediates the neurogenic effect of β-amyloid protein in cultured subventricular zone neurospheres (108 visite)
Calafiore M, Copani A, Deng W
Journal Of Neuroscience Research (ISSN: 0360-4012), 2012 Mar; 90(3): 559-567.
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (204 visite)
Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Monomeric beta-amyloid activities relay on specific receptor engagement (100 visite)
Giuffrida M, Tomasello F, Caraci F, Pandini G, Chiechio S, Pappalardo G, Vigneri R, Rizzarelli E, Nicoletti F, Copani AG
Society For Neuroscience Abstract Viewer And Itinerary Planner, 2012; 42: N/D-N/D.
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (258 visite)
Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
Dettagli    Esporta in BibTeX    Esporta in EndNote

* A new function for beta-amyloid monomers (114 visite)
Giuffrida M-, Tomasello F, Caraci F, Pandini G, Chiechio S, Battaglia G, De Bona P, Pappalardo G, Vigneri R, Nicoletti F, Rizzarelli E, Copani AG
Society For Neuroscience Abstract Viewer And Itinerary Planner, 2011; 41: N/D-N/D.
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Basic understanding of the activities of beta-amyloid (A beta) monomers (109 visite)
Giuffrida M, Tomasello F, Caraci F, Pappalardo G, Rizzarelli E, Nicoletti F, Copani AG
Society For Neuroscience Abstract Viewer And Itinerary Planner, 2010; 40: N/D-N/D.
Dettagli    Esporta in BibTeX    Esporta in EndNote

* The monomer state of beta-amyloid: where the Alzheimer's disease protein meets physiology (132 visite)
Giuffrida ML, Caraci F, De Bona P, Pappalardo G, Nicoletti F, Rizzarelli E, Copani A
Rev Neurosci (ISSN: 0334-1763), 2010; 21(2): 83-93.
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Beta-Amyloid Monomers Are Neuroprotective (159 visite)
Giuffrida ML, Caraci F, Pignataro B, Cataldo S, De Bona P, Bruno V, Molinaro G, Pappalardo G, Messina A, Palmigiano A, Garozzo D, Nicoletti F, Rizzarelli E, Copani A
The Journal Of Neuroscience (ISSN: 1529-2401), 2009 Sep 26; 29(34): 10582-10587.
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Design And Synthesis Of New Trehalose-Conjugated Pentapeptides As Inhibitors Of Abeta (1-42) Fibrillogenesis And Toxicity (170 visite)
De Bona P, Giuffrida ML, Caraci F, Copani A, Pignataro B, Attanasio F, Cataldo S, Pappalardo G, Rizzarelli E
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 220-228.
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Epigenetic modulation of mGlu2 receptors by histone deacetylase inhibitors in the treatment of inflammatory pain (100 visite)
Chiechio S, Zammataro M, Morales ME, Busceti CL, Drago F, Th Gereau RW, Copani A, Nicoletti F
Mol Pharmacol (ISSN: 0026-895x), 2009; 75(5): 1014-1020.
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Monomers of beta-amyloid protein are endowed with neuroprotective activity (104 visite)
Giuffrida M, Caraci F, Molinaro G, Cataldo S, Pignataro B, Bruno V, De Bona P, Pappalardo G, Messina A, Palmigiano A, Garozzo D, Nicoletti F, Rizzarelli E, Copani AG
Society For Neuroscience Abstract Viewer And Itinerary Planner, 2009; 39: N/D-N/D.
Dettagli    Esporta in BibTeX    Esporta in EndNote

* The Wnt antagonist, Dickkopf-1, as a target for the treatment of neurodegenerative disorders (85 visite)
Caraci F, Busceti C, Biagioni F, Aronica E, Mastroiacovo F, Cappuccio I, Battaglia G, Bruno V, Caricasole A, Copani A, Nicoletti
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2008 Dec; 33(12): 2401-2406.
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Designing trehalose-conjugated peptides for the inhibition of Alzheimer's A beta oligornerization and neurotoxicity (128 visite)
De Bona P, Giuffrida ML, Attanasio F, Copani A, Pignataro B, Cataldo S, Rizzarelli E, Pappalardo G
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Group I metabotropic glutamate receptors control proliferation, survival and differentiation of cultured neural progenitor cells isolated from the subventricular zone of adult mice (90 visite)
Castiglione M, Calafiore M, Costa L, Sortino MA, Nicoletti F, Copani A
Neuropharm (ISSN: 0028-3908, 1873-7064electronic, 0028-3908linking), 2008 Sep; 55(4): 560-567.
Dettagli    Esporta in BibTeX    Esporta in EndNote

* TGF-β1 protects against Aβ-neurotoxicity via the phosphatidylinositol-3-kinase pathway (102 visite)
Caraci F, Battaglia G, Busceti C, Biagioni F, Mastroiacovo F, Bosco P, Drago F, Nicoletti F, Sortino MA, Copani A
Neurobiology Of Disease (ISSN: 0969-9961), 2008 May; 30(2): 234-242.
Dettagli    Esporta in BibTeX    Esporta in EndNote

* The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (108 visite)
Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
Dettagli    Esporta in BibTeX    Esporta in EndNote

* The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (118 visite)
Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
Biochim Biophys Acta (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Abeta(25-35) And Its C- And/Or N-Blocked Derivatives: Copper Driven Structural Features And Neurotoxicity (149 visite)
Giuffrida ML, Grasso G, Ruvo M, Pedone C, Saporito A, Marasco D, Pignataro B, Cascio C, Copani A, Rizzarelli E
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Feb 15; 85(3): 623-633.
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Acetyl-l-carnitine in neuropathic pain (74 visite)
Chiechio S, Copani A, Gereau R, Nicoletti F
Cns Drugs (ISSN: 1172-7047), 2007; 21: 38-38.
Dettagli    Esporta in BibTeX    Esporta in EndNote

* The CDC2 I-G-T haplotype associated with the APOE ε4 allele increases the risk of sporadic Alzheimer's disease in Sicily (113 visite)
Bosco P, Caraci F, Copani A, Spada R, Sortino M, Salluzzo R, Salemi M, Nicoletti F, Ferri R
Neurosci Lett (ISSN: 0304-3940), 2007; 419(3): 195-198.
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* Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (131 visite)
Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
Journal Of Neuroscience (ISSN: 0270-6474, 0361-803x), 2006; 26(43): 10949-10957.
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to β-amyloid (87 visite)
Calafiore M, Battaglia G, Zappal A, Trovato-Salinaro E, Caraci F, Caruso M, Vancheri C, Sortino MA, Nicoletti F, Copani A
Neurobiol Aging (ISSN: 0197-4580, 1558-1497electronic), 2006; 27(4): 606-613.
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (99 visite)
Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
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* Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (116 visite)
Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F
Journal Of Neuroscience (ISSN: 0270-6474, 0361-803x), 2004 Jun 30; 24(26): 6021-6027.
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39 Records (32 escludendo Abstract e Conferenze).
Impact factor totale: 122.181 (116.013 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 120.008 (113.916 escludendo Abstract e Conferenze).








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