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Collegamenti

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NomeAgataGraziella Copani
AreaAssociati
QualificaAssociato
SedeCatania
Indirizzoc/o Dipartimento di Scienze Chimiche Viale Andrea Doria 6, 95125 Catania - Italy
E-mailacopanikatamail.com
Nessuna area di ricerca
Nessuna attivitá
Posizione accademica: Professore di Farmacologia, Dipartimento di
Scienze del Farmaco, Università di Catania. Formazione: 1984 - Maturità
Scientifica (60/60); 1990 - Laurea in Medicina e Chirurgia (110/110 e
Lode); 1991/92-"Postdoctoral researcher" presso il Dipartimento di
Psicobiologia, Università di Irvine, California; 1994 - Specializzazione
in Neurologia (50/50 e Lode); 1999 - Dottorato di Ricerca in
Neurobiologia; 2002 - Specializzazione in Biochimica e Chimica Clinica
(70/70 e Lode). Attività Scientifica: Ricerca in ambito
neurofarmacologico e neurobiologico, con particolare riguardo ai
meccanismi di degenerazione cellulare nella demenza d'Alzheimer.
Co-autrice di 116 articoli recensiti su Pubmed. Scholar H-index = 51.
2004 – ad oggi: Membro associato all’Istituto di Bioimmagini e
Biostrutture del CNR. Comitati Editoriali: Current Medicinal Chemistry,
Frontiers in Experimental Pharmacology and Drug discovery. Società
scientifiche: Società Italiana di Farmacologia e Società Americana di
Neuroscienze.

Contiene: [X]      Estesa     Autori: [X]  Tipo di lavoro: [X]   Data iniziale: Data finale: [X]      Sede: Affiliazione IBB     
    
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Bibliografia

Ordina per:   data    titolo    rivista    autori    impact factor

* Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (125 visite)
Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2004 Jun 30; 24(26): 6021-6027.
Impact Factor: 2.384
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (107 visite)
Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
Impact Factor: 1.995
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (140 visite)
Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2006; 26(43): 10949-10957.
Impact Factor: 2.117
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to β-amyloid (93 visite)
Calafiore M, Battaglia G, Zappal A, Trovato-Salinaro E, Caraci F, Caruso M, Vancheri C, Sortino MA, Nicoletti F, Copani A
Neurobiol Aging (ISSN: 0197-4580, 1558-1497electronic), 2006; 27(4): 606-613.
Impact Factor: 5.599
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Acetyl-l-carnitine in neuropathic pain (80 visite)
Chiechio S, Copani A, Gereau R, Nicoletti F
Cns Drugs (ISSN: 1172-7047), 2007; 21: 38-38.
Impact Factor: 4.514
Dettagli    Esporta in BibTeX    Esporta in EndNote

* The CDC2 I-G-T haplotype associated with the APOE ε4 allele increases the risk of sporadic Alzheimer's disease in Sicily (120 visite)
Bosco P, Caraci F, Copani A, Spada R, Sortino M, Salluzzo R, Salemi M, Nicoletti F, Ferri R
Neurosci Lett (ISSN: 0304-3940), 2007; 419(3): 195-198.
Impact Factor: 2.085
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Abeta(25-35) And Its C- And/Or N-Blocked Derivatives: Copper Driven Structural Features And Neurotoxicity (156 visite)
Giuffrida ML, Grasso G, Ruvo M, Pedone C, Saporito A, Marasco D, Pignataro B, Cascio C, Copani A, Rizzarelli E
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Feb 15; 85(3): 623-633.
Impact Factor: 3.268
Dettagli    Esporta in BibTeX    Esporta in EndNote

* The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (124 visite)
Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
Biochim Biophys Acta (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
Impact Factor: 3.078
Dettagli    Esporta in BibTeX    Esporta in EndNote

* The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (128 visite)
Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
Impact Factor: 4.823
Dettagli    Esporta in BibTeX    Esporta in EndNote

* TGF-β1 protects against Aβ-neurotoxicity via the phosphatidylinositol-3-kinase pathway (110 visite)
Caraci F, Battaglia G, Busceti C, Biagioni F, Mastroiacovo F, Bosco P, Drago F, Nicoletti F, Sortino MA, Copani A
Neurobiology Of Disease (ISSN: 0969-9961), 2008 May; 30(2): 234-242.
Impact Factor: 4.852
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Designing trehalose-conjugated peptides for the inhibition of Alzheimer's A beta oligornerization and neurotoxicity (140 visite)
De Bona P, Giuffrida ML, Attanasio F, Copani A, Pignataro B, Cataldo S, Rizzarelli E, Pappalardo G
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
Impact Factor: 1.654
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Group I metabotropic glutamate receptors control proliferation, survival and differentiation of cultured neural progenitor cells isolated from the subventricular zone of adult mice (97 visite)
Castiglione M, Calafiore M, Costa L, Sortino MA, Nicoletti F, Copani A
Neuropharm (ISSN: 0028-3908, 1873-7064electronic, 0028-3908linking), 2008 Sep; 55(4): 560-567.
Impact Factor: 3.383
Dettagli    Esporta in BibTeX    Esporta in EndNote

* The Wnt antagonist, Dickkopf-1, as a target for the treatment of neurodegenerative disorders (91 visite)
Caraci F, Busceti C, Biagioni F, Aronica E, Mastroiacovo F, Cappuccio I, Battaglia G, Bruno V, Caricasole A, Copani A, Nicoletti
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2008 Dec; 33(12): 2401-2406.
Impact Factor: 2.26
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Epigenetic modulation of mGlu2 receptors by histone deacetylase inhibitors in the treatment of inflammatory pain (109 visite)
Chiechio S, Zammataro M, Morales ME, Busceti CL, Drago F, Th Gereau RW, Copani A, Nicoletti F
Mol Pharmacol (ISSN: 0026-895x), 2009; 75(5): 1014-1020.
Impact Factor: 4.531
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Monomers of beta-amyloid protein are endowed with neuroprotective activity (113 visite)
Giuffrida M, Caraci F, Molinaro G, Cataldo S, Pignataro B, Bruno V, De Bona P, Pappalardo G, Messina A, Palmigiano A, Garozzo D, Nicoletti F, Rizzarelli E, Copani AG
Society For Neuroscience Abstract Viewer And Itinerary Planner, 2009; 39: N/D-N/D.
Impact Factor: 0
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Design And Synthesis Of New Trehalose-Conjugated Pentapeptides As Inhibitors Of Abeta (1-42) Fibrillogenesis And Toxicity (182 visite)
De Bona P, Giuffrida ML, Caraci F, Copani A, Pignataro B, Attanasio F, Cataldo S, Pappalardo G, Rizzarelli E
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 220-228.
Impact Factor: 1.807
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Beta-Amyloid Monomers Are Neuroprotective (169 visite)
Giuffrida ML, Caraci F, Pignataro B, Cataldo S, De Bona P, Bruno V, Molinaro G, Pappalardo G, Messina A, Palmigiano A, Garozzo D, Nicoletti F, Rizzarelli E, Copani A
J Neurosci (ISSN: 1529-2401, 0270-6474), 2009 Sep 26; 29(34): 10582-10587.
Impact Factor: 3.669
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Basic understanding of the activities of beta-amyloid (A beta) monomers (115 visite)
Giuffrida M, Tomasello F, Caraci F, Pappalardo G, Rizzarelli E, Nicoletti F, Copani AG
Society For Neuroscience Abstract Viewer And Itinerary Planner, 2010; 40: N/D-N/D.
Impact Factor: 0
Dettagli    Esporta in BibTeX    Esporta in EndNote

* The monomer state of beta-amyloid: where the Alzheimer's disease protein meets physiology (143 visite)
Giuffrida ML, Caraci F, De Bona P, Pappalardo G, Nicoletti F, Rizzarelli E, Copani A
Rev Neurosci (ISSN: 0334-1763), 2010; 21(2): 83-93.
Impact Factor: 2.047
Dettagli    Esporta in BibTeX    Esporta in EndNote

* A new function for beta-amyloid monomers (120 visite)
Giuffrida M-, Tomasello F, Caraci F, Pandini G, Chiechio S, Battaglia G, De Bona P, Pappalardo G, Vigneri R, Nicoletti F, Rizzarelli E, Copani AG
Society For Neuroscience Abstract Viewer And Itinerary Planner, 2011; 41: N/D-N/D.
Impact Factor: 0
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (267 visite)
Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
Impact Factor: 4.883
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Monomeric beta-amyloid activities relay on specific receptor engagement (106 visite)
Giuffrida M, Tomasello F, Caraci F, Pandini G, Chiechio S, Pappalardo G, Vigneri R, Rizzarelli E, Nicoletti F, Copani AG
Society For Neuroscience Abstract Viewer And Itinerary Planner, 2012; 42: N/D-N/D.
Impact Factor: 0
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (234 visite)
Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
Impact Factor: 3.677
Dettagli    Esporta in BibTeX    Esporta in EndNote

* DNA polymerase-β mediates the neurogenic effect of β-amyloid protein in cultured subventricular zone neurospheres (154 visite)
Calafiore M, Copani A, Deng W
Journal Of Neuroscience Research (ISSN: 0360-4012), 2012 Mar; 90(3): 559-567.
Impact Factor: 2.974
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Metabotropic glutamate receptors in neurodegeneration/neuroprotection: Still a hot topic? (153 visite)
Caraci F, Battaglia G, Sortino MA, Spampinato S, Molinaro G, Copani A, Nicoletti F, Bruno V
Neurochem Int (ISSN: 0197-0186), 2012 Sep; 61(4): 559-565.
Impact Factor: 2.659
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Beta-Amyloid monomer and insulin/IGF-1 signaling in Alzheimer's disease (151 visite)
Giuffrida ML, Tomasello F, Caraci F, Chiechio S, Nicoletti F, Copani A
Mol Neurobiol (ISSN: 0893-7648), 2012 Dec; 46(3): 605-613.
Impact Factor: 5.471
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Shared and distinct features of beta-amyloid peptides (126 visite)
Giuffrida M, Caraci F, Tomasello F, Pappalardo G, Rizzarelli E, Nicoletti F, Copani AG
Society For Neuroscience Abstract Viewer And Itinerary Planner, 2013; 43: N/D-N/D.
Impact Factor: 0
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Insulin has multiple antiamyloidogenic effects on human neuronal cells (164 visite)
Pandini G, Pace V, Copani A, Squatrito S, Milardi D, Vigneri R
Endocrinology (ISSN: 0013-7227, 1945-7170), 2013 Jan; 154(1): 375-387.
Impact Factor: 4.644
Dettagli    Esporta in BibTeX    Esporta in EndNote

* A ratiometric naphthalimide sensor for live cell imaging of copper(i) (116 visite)
Satriano C, Sfrazzetto GT, Amato ME, Ballistreri FP, Copani A, Giuffrida ML, Grasso G, Pappalardo A, Rizzarelli E, Tomaselli GA, Toscano RM
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2013 Jun 21; 49(49): 5565-5567.
Impact Factor: 6.718
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity (3 visite)
Merlo S, Basile L, Giuffrida ML, Sortino MA, Guccione S, Copani A
J Nat Prod (ISSN: 0163-3864), 2015; 78(11): 2704-2711.
Impact Factor:
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Neuroprotective effects of the monoamine oxidase inhibitor Tranylcypromine and its amide derivatives against Abeta(1-42)-induced toxicity (176 visite)
Caraci F, Pappalardo G, Basile L, Giuffrida A, Copani A, Tosto R, Sinopoli A, Giuffrida ML, Pirrone E, Drago F, Pignatello R, Guccione S
Eur J Pharmacol (ISSN: 1879-0712electronic, 0014-2999linking), 2015 Jul 7; 764: 256-263.
Impact Factor: 2.73
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Monomeric ss-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons (176 visite)
Giuffrida ML, Tomasello MF, Pandini G, Caraci F, Battaglia G, Busceti C, Di Pietro P, Pappalardo G, Attanasio F, Chiechio S, Bagnoli S, Nacmias B, Sorbi S, Vigneri R, Rizzarelli E, Nicoletti F, Copani A
Front Cell Neurosci (ISSN: 1662-5102electronic, 1662-5102linking), 2015 Aug 7; 9(AUGUST): 297-297.
Impact Factor: 4.609
Dettagli    Esporta in BibTeX    Esporta in EndNote

* The antineoplastic drug flavopiridol reverses memory impairment induced by Amyloid-ss1-42 oligomers in mice (112 visite)
Leggio GM, Catania MV, Puzzo D, Spatuzza M, Pellitteri R, Gulisano W, Torrisi SA, Giurdanella G, Piazza C, Impellizzeri AR, Gozzo L, Navarria A, Bucolo C, Nicoletti F, Palmeri A, Salomone S, Copani A, Caraci F, Drago F
Pharmacol Res (ISSN: 1096-1186electronic, 1043-6618linking), 2016 Apr; 106: 10-20.
Impact Factor: 4.48
Dettagli    Esporta in BibTeX    Esporta in EndNote

* The impact of metabotropic glutamate receptors into active neurodegenerative processes: A "dark side" in the development of new symptomatic treatments for neurologic and psychiatric disorders (76 visite)
Caraci F, Bruno V, Copani A, Matrisciano F, Nicoletti F, Battaglia G
Neuropharm (ISSN: 1873-7064electronic, 0028-3908linking), 2016 Apr 30; N/D: N/D-N/D.
Impact Factor: 5.012
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Ac-LPFFD-Th: A Trehalose-Conjugated Peptidomimetic as a Strong Suppressor of Amyloid-beta Oligomer Formation and Cytotoxicity (115 visite)
Sinopoli A, Giuffrida A, Tomasello MF, Giuffrida ML, Leone M, Attanasio F, Caraci F, De Bona P, Naletova I, Saviano M, Copani A, Pappalardo G, Rizzarelli E
Chembiochem (ISSN: 1439-7633electronic, 1439-4227linking), 2016 Aug 17; 17(16): 1541-1549.
Impact Factor: 2.847
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Fluoxetine Prevents Ab1-42-Induced Toxicity via a Paracrine Signaling Mediated by Transforming-Growth- Factor-b1 (77 visite) (PDF 110 visite)
Caraci F, Tascedda F, Merlo F, Benatti C, Spampinato S, Munafò A, Leggio GM, Nicoletti F, Brunello N, Drago F, Sortino MA, Copani A
Frontiers In Pharmacology, 2016 Oct; 7: 1-11.
Impact Factor: 4.418
Dettagli    Esporta in BibTeX    Esporta in EndNote

* The underexplored question of beta-amyloid monomers (61 visite)
Copani A
Eur J Pharmacol (ISSN: 1879-0712electronic, 0014-2999linking), 2017 May 31; N/D: N/D-N/D.
Impact Factor: 2.896
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Amyloid Beta monomers regulate cyclic adenosine monophosphate response element binding protein functions by activating type-1 insulin-like growth factor receptors in neuronal cells (382 visite) (PDF 100 visite)
Zimbone S, Monaco I, Giani F, Pandini G, Copani AG, Giuffrida ML, Rizzarelli E
Aging Cell (ISSN: 1474-9726electronic, 1474-9718linking), 2017 Nov 01; N/D: N/D-N/D.
Impact Factor: 6.714
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Metabotropic glutamate receptors: the potential for therapeutic applications in Alzheimer's disease (68 visite)
Caraci F, Nicoletti F, Copani A
Curr Opin Pharmacol (ISSN: 1471-4973electronic, 1471-4892linking), 2017 Dec 23; 38: 1-7.
Impact Factor: 0
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system (75 visite)
Di Menna L, Joffe ME, Iacovelli L, Orlando R, Lindsley CW, Mairesse J, Gressèns P, Cannella M, Caraci F, Copani A, Bruno V, Battaglia G, Conn PJ, Nicoletti F
Neuropharm (ISSN: 0028-3908linking, 1873-7064electronic), 2018 Jan; 128: 301-313.
Impact Factor: 3.383
Dettagli    Esporta in BibTeX    Esporta in EndNote

* A promising connection between BDNF and Alzheimer's disease (13 visite)
Giuffrida ML, Copani A, Rizzarelli E
Aging (ISSN: 1945-4589linking), 2018 Aug 6; 10(8): 1791-1792.
Impact Factor: 0
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Metabotropic Glutamate Receptors in Glial Cells: A New Potential Target for Neuroprotection? (13 visite)
Spampinato SF, Copani A, Nicoletti F, Sortino MA, Caraci F
Frontiers In Molecular Neuroscience (ISSN: 1662-5099, 1662-5099linking), 2018 Nov 13; 11: 414-414.
Impact Factor: 3.902
Dettagli    Esporta in BibTeX    Esporta in EndNote



42 Records (35 escludendo Abstract e Conferenze).
Impact factor totale: 126.083 (119.915 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 120.008 (113.916 escludendo Abstract e Conferenze).








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