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 Foto | | Nome | Luciana Esposito | Area | Ricerca e Sviluppo | Qualifica | Ricercatore | Sede | Napoli-Mezzocannone | Indirizzo | Via Mezzocannone 16, 80134 Napoli - Italia | E-mail | luciana.esposito cnr.it | Telefono ufficio | +39 081 2536614 |
July 1995: Chemistry Degree (summa cum laude), at the University of Naples Federico II presenting a thesis which received the "G. Laonigro" award from the Italian Chemical Society. 1995-1998: Ph. D. in Protein Crystallography, Department of Chemistry, University of Naples Federico II. 1998-1999: Temporary Fellow at the CNR Biocrystallography Research Center-Naples". 2003: Short-term fellowship award from the International Human Frontier Science Program Organization. June-Oct. 2003: Visiting scientist at the University of Washington, Seattle, USA. May 2010: Visiting scientist at the University of Cambridge, UK. Since Dec. 2001: Permanent staff scientist at the CNR-IBB. My scientific interests lie in the general area of Structural Biology with an emphasis on computational techniques applied to the study of macromolecular systems. Indeed, my expertise in experimental macromolecular crystallography has been complemented by theoretical approaches such as statistical analyses on structural databases, molecular modeling, and molecular dynamics (MD) simulations. The main results of my research activities have been achieved in the following fields: (i) the study of the deamidation process and its structural effects in proteins (ii) protein crystallization in microgravity conditions (iii) ultra-high resolution protein structural studies (iv) structural studies of extremophilic dehydrogenases (v) statistical analyses of databases to unveil novel details and properties of protein structures (vi) MD study of the dynamical behaviour of proteins and/or polypeptide fragments involved in the misfolding process, eventually leading to amyloid fiber formation (vii) the study of disease-causing mutations in human proteins. |
Bibliografia Ordina per: data ▼▲ titolo ▲ ▼ rivista ▲ ▼ autori ▲ ▼ impact factor ▲ ▼* The optical properties of adenine cation in different oligonucleotides: a PCM/TD‑DFT study (8 visite) (PDF 8 visite)Martinez Fernandez L, Muñoz-losa A, Esposito L, Improta R Theor Chem Acc (ISSN: 1432-881x), 2018; 137(3): N/D-N/D.Impact Factor: 1.545Dettagli Esporta in BibTeX Esporta in EndNote* Multiple Electronic and Structural Factors Control Cyclobutane Pyrimidine Dimer and 6-4 Thymine-Thymine Photodimerization in a DNA Duplex (53 visite)Conti I, Martinez-fernandez L, Esposito L, Hofinger S, Nenov A, Garavelli M, Improta R Chemistry (ISSN: 1521-3765electronic, 0947-6539linking), 2017 Oct 26; 23(60): 15177-15188.Impact Factor: 5.476Dettagli Esporta in BibTeX Esporta in EndNote* Factors affecting the amplitude of the tau angle in proteins: a revisitation (87 visite)Balasco N, Esposito L, Vitagliano L Acta Crystallogr D Struct Biol (ISSN: 2059-7983electronic, 2059-7983linking), 2017 Jul 01; 73(Pt7): 618-625.Impact Factor: 2.114Dettagli Esporta in BibTeX Esporta in EndNote* UV-induced damage to DNA: effect of cytosine methylation on pyrimidine dimerization (47 visite)Martinez-fernandez L, Banyasz A, Esposito L, Markovitsi D, Improta R Signal Transduction And Targeted Therapy, 2017 Jun; N/D: N/D-N/D.Impact Factor: 0Dettagli Esporta in BibTeX Esporta in EndNote* Dissection of Factors Affecting the Variability of the Peptide Bond Geometry and Planarity (39 visite)Balasco N, Esposito L, Thind AS, Guarracino MR, Vitagliano L Biomed Res Int (ISSN: 2314-6141electronic, 2314-6133), 2017; 2017: 2617629-2617629.Impact Factor: 1.579Dettagli Esporta in BibTeX Esporta in EndNote* Excited State Pathways Leading to Formation of Adenine Dimers (88 visite)Banyasz A, Martinez-fernandez L, Ketola TM, Munoz-losa A, Esposito L, Markovitsi D, Improta R J Phys Chem Lett (ISSN: 1948-7185electronic, 1948-7185linking), 2016 Jun 2; 7(11): 2020-2023.Impact Factor: 9.353Dettagli Esporta in BibTeX Esporta in EndNote* Effect of C5-Methylation of Cytosine on the UV-Induced Reactivity of Duplex DNA: Conformational and Electronic Factors (92 visite)Banyasz A, Esposito L, Douki T, Perron M, Lepori C, Improta R, Markovitsi D J Phys Chem B (ISSN: 1520-5207electronic, 1520-5207linking, 1520-6106), 2016 May 12; 120(18): 4232-4242.Impact Factor: 3.177Dettagli Esporta in BibTeX Esporta in EndNote* The determinants of bond angle variability in protein/peptide backbones: A comprehensive statistical/quantum mechanics analysis (83 visite)Improta R, Vitagliano L, Esposito L Proteins (ISSN: 1097-0134electronic, 0887-3585linking), 2015 Nov; 83(11): 1973-1986.Impact Factor: 2.499Dettagli Esporta in BibTeX Esporta in EndNote* Cullin3 - BTB interface: A novel target for stapled peptides (193 visite)De Paola I, Pirone L, Palmieri M, Balasco N, Esposito L, Russo L, Mazza D, Di Marcotullio L, Di Gaetano S, Malgieri G, Vitagliano L, Pedone E, Zaccaro L Plosone (ISSN: 1932-6203, 1932-6203electronic), 2015 Apr 7; 10(4): e0121149-e0121149.Impact Factor: 3.057Dettagli Esporta in BibTeX Esporta in EndNote* Bond distances in polypeptide backbones depend on the local conformation (99 visite)Improta R, Vitagliano L, Esposito L Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2015; 71: 1272-1283.Impact Factor: 2.51Dettagli Esporta in BibTeX Esporta in EndNote* Effect of C5-methylation of cytosine on the photoreactivity of DNA: A joint experimental and computational study of TCG trinucleotides (107 visite)Esposito L, Banyasz A, Douki T, Perron M, Markovitsi D, Improta R J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2014 Sep 6; 136(31): 10838-10841.Impact Factor: 12.113Dettagli Esporta in BibTeX Esporta in EndNote* Molecular recognition of Cullin3 by KCTDs: Insights from experimental and computational investigations (119 visite)Balasco N, Pirone L, Smaldone G, Di Gaetano S, Esposito L, Pedone E, Vitagliano L Biochim Biophys Acta (ISSN: 1570-9639, 0006-3002, 0925-4439), 2014 Jul; 1844(7): 1289-1298.Impact Factor: 2.747Dettagli Esporta in BibTeX Esporta in EndNote* Correction: Peptide bond distortions from planarity: New insights from quantum mechanical calculations and peptide/protein crystal structures (PLoS ONE) (87 visite)Improta R, Vitagliano L, Esposito L Plosone (ISSN: 1932-6203, 1932-6203electronic), 2014; 9(1): N/D-N/D.Impact Factor: 3.234Dettagli Esporta in BibTeX Esporta in EndNote* Role of loops connecting secondary structure elements in the stabilization of proteins isolated from thermophilic organisms (108 visite)Balasco N, Esposito L, De Simone A, Vitagliano L Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 2013 Jul; 22(7): 1016-1023.Impact Factor: 2.861Dettagli Esporta in BibTeX Esporta in EndNote* The Intrinsic Stability Of The Human Prion Beta-Sheet Region Investigated By Molecular Dynamics (174 visite)De Simonea A, Stanzione F, Marasco D, Vitagliano L, Esposito L Journal Of Biomolecular Structure & Dynamics, 2013 May 1; 31(5): 441-452.Impact Factor: 2.983Dettagli Esporta in BibTeX Esporta in EndNote* Biochemical and structural characterization of recombinant short-chain NAD(H)-dependent dehydrogenase/reductase from Sulfolobus acidocaldarius highly enantioselective on diaryl diketone benzil (156 visite)Pennacchio A, Sannino V, Sorrentino G, Rossi M, Raia CA, Esposito L Applied Microbiology And Biotechnology (ISSN: 0175-7598), 2013 May; 97(9): 1-16.Impact Factor: 3.811Dettagli Esporta in BibTeX Esporta in EndNote* FOR the RECORD: Role of loops connecting secondary structure elements in the stabilization of proteins isolated from thermophilic organisms (138 visite)Balasco N, Esposito L, De Simone A, Vitagliano L Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 2013; 22(7): 1016-1023.Impact Factor: 2.861Dettagli Esporta in BibTeX Esporta in EndNote* Interplay between peptide bond geometrical parameters in nonglobular structural contexts (137 visite)Esposito L, Balasco N, De Simone A, Berisio R, Vitagliano L Biomed Res Int (ISSN: 2314-6133, 2314-6141, 2314-6141electronic), 2013; 2013: N/D-N/D.Impact Factor: 2.13Dettagli Esporta in BibTeX Esporta in EndNote* Dynamical Properties of Steric Zipper Polymorphs Formed by a IAPP-Derived Peptide (146 visite)Stanzione F, De Simone A, Esposito L, Vitagliano L Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2012 Sep; 19(8): 846-851.Impact Factor: 1.994Dettagli Esporta in BibTeX Esporta in EndNote* Crystallographic and spectroscopic characterizations of Sulfolobus solfataricus TrxA1 provide insights into the determinants of thioredoxin fold stability (118 visite)Esposito L, Ruggiero A, Masullo M, Ruocco MR, Lamberti A, Arcari P, Zagari A, Vitagliano L Journal Of Structural Biology (ISSN: 1047-8477), 2012 Feb; 177(2): 506-512.Impact Factor: 3.361Dettagli Esporta in BibTeX Esporta in EndNote* Peptide bond distortions from planarity: New insights from quantum mechanical calculations and peptide/protein crystal structures (144 visite)Improta R, Vitagliano L, Esposito L Plosone (ISSN: 1932-6203, 1932-6203electronic), 2011 Sep 16; 6(9): e24533-e24533.Impact Factor: 4.092Dettagli Esporta in BibTeX Esporta in EndNote* Role of the conformational versatility of the neurotrophin N-terminal regions in their recognition by Trk receptors (110 visite)Stanzione F, Esposito L, Paladino A, Pedone C, Morelli G, Vitagliano L Biophysical Journal (ISSN: 1542-0086, 0006-3495), 2010 Oct 6; 99(7): 2273-2278.Impact Factor: 4.218Dettagli Esporta in BibTeX Esporta in EndNote* Probing The Peptidylglycine Alpha-Hydroxylating Monooxygenase Active Site With Novel 4-Phenyl-3-Butenoic Acid Based Inhibitors (148 visite)Langella E, Pierre S, Ghattas W, Giorgi M, Réglier M, Saviano M, Esposito L, Hardré R Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2010 Sep 3; 5(9): 1568-1576.Impact Factor: 3.306Dettagli Esporta in BibTeX Esporta in EndNote* Functional analysis of melanocortin-4-receptor mutants identified in severely obese subjects living in Southern Italy (137 visite)Alfieri A, Pasanisi F, Salzano S, Esposito L, Martone D, Tafuri D, Daniele A, Contaldo F, Sacchetti L, Zagari A, Buono P Gene (ISSN: 0378-1119), 2010 Jun 1; 457(1-2): 35-41.Impact Factor: 2.266Dettagli Esporta in BibTeX Esporta in EndNote* Insight into the stereospecificity of short-chain Thermus thermophilus alcohol dehydrogenase showing pro-S hydride transfer and Prelog enantioselectivity (127 visite)Pennacchio A, Giordano A, Esposito L, Langella E, Rossi M, Raia CA Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2010 Apr; 17(4): 437-443.Impact Factor: 1.849Dettagli Esporta in BibTeX Esporta in EndNote* Exploring Phm Active Site: Characterization Of Novel Pba-Derived Inhibitors Using A Combined Experimental And Computational Approach (90 visite)Langella E, Pierre S, Ghattas W, Giorgi M, Rglier M, Saviano M, Esposito L, Hardr R Chemmedchem, 2010; 5: 1568-1576.Impact Factor: 3.046Dettagli Esporta in BibTeX Esporta in EndNote* Nonsynonimous mutation of catechol-O-methyl-transferase (COMT) gene in a patient with temporomandibular disorder (141 visite)D'Antò V, Michelotti A, Esposito L, Zagari A, Liguori R, Sacchetti L J Sci Med Sport (ISSN: 1440-2440), 2010; 13(6): 174-179.Impact Factor: 0Dettagli Esporta in BibTeX Esporta in EndNote* Dynamics and Stability of Amyloid-Like Steric Zipper Assemblies with Hydrophobic Dry Interfaces (148 visite)Vitagliano L, Stanzione F, De Simone A, Esposito L Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2009 Dec; 91(12): 1161-1171.Impact Factor: 2.605Dettagli Esporta in BibTeX Esporta in EndNote* Role of Tryptophan 95 in substrate specificity and structural stability of Sulfolobus solfataricus alcohol dehydrogenase (104 visite)Pennacchio A, Esposito L, Zagari A, Rossi M, Raia CA Extremophiles (ISSN: 1431-0651, 1433-4909, 1433-4909electronic), 2009 Sep; 13(5): 751-761.Impact Factor: 2Dettagli Esporta in BibTeX Esporta in EndNote* Functional and structural characterization of novel mutations and genotype-phenotype correlation in 51 phenylalanine hydroxylase deficient families from Southern Italy (106 visite)Daniele A, Scala I, Cardillo G, Pennino C, Ungaro C, Sibilio M, Parenti G, Esposito L, Zagari A, Andria G, Salvatore F Febs Journal (ISSN: 1742-464x), 2009 Apr; 276(7): 2048-2059.Impact Factor: 3.042Dettagli Esporta in BibTeX Esporta in EndNote* Stability of single sheet GNNQQNY aggregates analyzed by replica exchange molecular dynamics: antiparallel versus parallel association (172 visite)Vitagliano L, Esposito L, Pedone C, De Simone A Biochem Biophys Res Commun (ISSN: 1090-2104, 0006-291x, 1090-2104electronic), 2008 Dec 26; 377(4): 1036-1041.Impact Factor: 2.648Dettagli Esporta in BibTeX Esporta in EndNote* The crystal structure of the superoxide dismutase from Helicobacter pylori reveals a structured C-terminal extension (108 visite)Esposito L, Seydel A, Aiello R, Sorrentino G, Cendron L, Zanotti G, Zagari Biochim Biophys Acta (ISSN: 1570-9639, 0006-3002, 0925-4439), 2008 Nov; 1784(11): 1601-1606.Impact Factor: 2.233Dettagli Esporta in BibTeX Esporta in EndNote* Insights into stability and toxicity of amyloid-like oligomers by replica exchange molecular dynamics analyses (133 visite)De Simone A, Esposito L, Pedone C, Vitagliano L Biophysical Journal (ISSN: 1542-0086, 0006-3495), 2008 Sep 15; 95(4): 1965-1973.Impact Factor: 4.683Dettagli Esporta in BibTeX Esporta in EndNote* Five human phenylalanine hydroxylase proteins identified in mild hyperphenylalaninemia patients are disease-causing variants (106 visite)Daniele A, Cardillo G, Pennino C, Carbone MT, Scognamiglio D, Esposito L, Correra A, Castaldo G, Zagari A, Salvatore F Biochim Biophys Acta (ISSN: 0925-4439, 0006-3002, 1570-9639), 2008 Jun; 1782(6): 378-384.Impact Factor: 2.233Dettagli Esporta in BibTeX Esporta in EndNote* Insights into structure, stability, and toxicity of monomeric and aggregated polyglutamine models from molecular dynamics simulations (132 visite)Esposito L, Paladino A, Pedone C, Vitagliano L Biophysical Journal (ISSN: 1542-0086, 0006-3495), 2008 May 15; 94(10): 4031-4040.Impact Factor: 4.683Dettagli Esporta in BibTeX Esporta in EndNote* Molecular dynamics analyses of cross-beta-spine steric zipper models: beta-sheet twisting and aggregation (182 visite)Esposito L, Pedone C, Vitagliano L Proc Natl Acad Sci U S A (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2006 Sep 1; 103(31): 11533-11538.Impact Factor: 9.643Dettagli Esporta in BibTeX Esporta in EndNote* Polyglutamine Repeats And Beta-Helix Structure: Molecular Dynamics Study (148 visite)Merlino A, Esposito L, Vitagliano L Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Jun 1; 63(4): 918-927.Impact Factor: 3.73Dettagli Esporta in BibTeX Esporta in EndNote* Correlation Between Omega And Psi Dihedral Angles In Protein Structures (114 visite)Esposito L, De Simone A, Zagari A, Vitagliano L J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2005 Apr 1; 347(3): 483-487.Impact Factor: 5.229Dettagli Esporta in BibTeX Esporta in EndNote* Insight into ribonuclease A domain swapping by molecular dynamics unfolding simulations (130 visite)Esposito L, Daggett V Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2005 Mar 8; 44(9): 3358-3368.Impact Factor: 3.848Dettagli Esporta in BibTeX Esporta in EndNote* Crystal structure of a ternary complex of the alcohol dehydrogenase from Sulfolobus solfataricus (125 visite)Esposito L, Bruno I, Sica F, Raia CA, Giordano A, Rossi M, Mazzarella L, Zagari A Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2003 Dec 16; 42(49): 14397-14407.Impact Factor: 3.922Dettagli Esporta in BibTeX Esporta in EndNote* Structural study of a single-point mutant of Sulfolobus solfataricus alcohol dehydrogenase with enhanced activity (110 visite)Esposito L, Bruno I, Sica F, Raia CA, Giordano A, Rossi M, Mazzarella L, Zagari A Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2003 Mar 27; 539(1-3): 14-18.Impact Factor: 3.609Dettagli Esporta in BibTeX Esporta in EndNote* Crystal Structure Of The Alcohol Dehydrogenase From The Hyperthermophilic Archaeon Sulfolobus Solfataricus At 1. 85 Angstrom Resolution (121 visite)Esposito L, Sica F, Raia CA, Giordano A, Rossi M, Mazzarella L, Zagari A J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2002 Apr 26; 318(2): 463-477.Impact Factor: 5.359Dettagli Esporta in BibTeX Esporta in EndNote* Recent advances in atomic resolution protein crystallography (111 visite)Esposito L, Vitagliano L, Mazzarella L Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2002 Apr; 9(2): 95-105.Impact Factor: 0.622Dettagli Esporta in BibTeX Esporta in EndNoteEffect of deamidation on folding of ribonuclease (77 visite)Orru S, Vitagliano L, Esposito L, Mazzarella L, Marino G, Ruoppolo M Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 2000 Dec; 9(12): 2577-2582.Impact Factor: 3.869Dettagli Esporta in BibTeX Esporta in EndNoteExperimental evidence for the correlation of bond distances in peptide groups detected in ultrahigh-resolution protein structures (101 visite)Esposito L, Vitagliano L, Zagari A, Mazzarella L Protein Eng (ISSN: 0269-2139, 0269-2139print, 0269-2139linking), 2000 Dec; 13(12): 825-828.Impact Factor: 2.442Dettagli Esporta in BibTeX Esporta in EndNotePyramidalization of backbone carbonyl carbon atoms in proteins (107 visite)Esposito L, Vitagliano L, Zagari A, Mazzarella L Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 2000 Oct; 9(10): 2038-2042.Impact Factor: 3.869Dettagli Esporta in BibTeX Esporta in EndNoteThe ultrahigh resolution crystal structure of ribonuclease A containing an isoaspartyl residue: Hydration and sterochemical analysis (171 visite)Esposito L, Vitagliano L, Sica F, Sorrentino G, Zagari A, Mazzarella L J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2000 Mar 31; 297(3): 713-732.Impact Factor: 5.388Dettagli Esporta in BibTeX Esporta in EndNoteProtein Crystal Growth In The Advance Protein Crystallisation Facility On The Lms Mission: A Comparison Of Sulfolobus Solfataricus Alchool Dehydrogenase Crystals Grown On The Ground And In Microgravity (75 visite) Esposito L, Sica F, Sorrentino G, Berisio R, Carotenuto L, Giordano A, Raia C, Rossi M, Lamzin VS, Willson KS, Zagari A Acta Crystallogr D Biol Crystallogr, 1998; 54: 386-390.Impact Factor: 0Dettagli Esporta in BibTeX Esporta in EndNoteProtein crystal growth in the advanced protein crystallization facility on the LMS mission: A comparison of Sulfolobus solfataricus alcohol dehydrogenase crystals grown on the ground and in microgravity (101 visite)Esposito L, Sica F, Sorrentino G, Berisio R, Carotenuto L, Giordano A, Raia CA, Rossi M, Lamzin VS, Wilson KS, Zagari A Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 1998; 54(3): 386-390.Impact Factor: 2.244Dettagli Esporta in BibTeX Esporta in EndNoteDeamidation in proteins: The crystal structure of bovine pancreatic ribonuclease with an isoaspartyl residue at position 67 (97 visite)Capasso S, Di Donato A, Esposito L, Sica F, Sorrentino G, Vitagliano L, Zagari A, Mazzarella L J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 1996; 257(3): 492-496.Impact Factor: 5.673Dettagli Esporta in BibTeX Esporta in EndNote50 Records ( 49 escludendo Abstract e Conferenze). Impact factor totale: 171.756 ( 167.664 escludendo Abstract e Conferenze). Impact factor a 5 anni totale: 176.321 ( 171.784 escludendo Abstract e Conferenze). Ultima modifica di Luciana Esposito in data Monday 08 January 2018, 16:26:39 1110 visite. Ultima visita in data Thursday 14 February 2019, 16:09:33
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