BDNF Val66Met polymorphism and brain volumes in multiple sclerosis

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BDNF Val66Met polymorphism and brain volumes in multiple sclerosis (91 views) (PDF restricted 60 views)

Dinacci D, Tessitore A, Russo AA, De Bonis ML, Lavorgna L, Picconi O, Sacco R, Bonavita S, Gallo A, Servillo G, Marcuccio L, Comerci M, Galletti P, Alfano B, Tedeschi G

Neurol Sci (ISSN: 1590-1874, 1590-3478, 1590-1874linking), 2011 Feb; 32(1): 117-123.

Abstract
Brain derived neurotrophic factor (BDNF) regulates several CNS physiological and pathological processes. To investigate in multiple sclerosis (MS) patients, the relationship between the Val66Met polymorphism of BDNF and clinical markers of disease activity and MRI markers of focal and diffuse brain pathologies. 45 MS patients and 34 healthy controls (HCs) were genotyped and subjected to clinical-MRI examination. Global white matter fraction (gWM-f), gray matter-f (GM-f), cerebrospinal fluid-f (CSF-f), and abnormal WM-f were measured. We studied 26 Val/Val and 19 Val/Met patients and 23 Val/Val and 11 Val/Met HCs. We found that Val/Val patients had lower GM-f and higher CSF-f than Val/Val HCs; such differences were not statistically significant comparing Val/Met patients to HCs. The regression analysis showed that both Val/Met genotype and relapse number were associated with lower CSF-f. Our data suggest that Met allele might be a protective factor against MS as it is associated to a lower brain atrophy. © 2010 Springer-Verlag.

Affiliations ▼

*** IBB - CNR Affiliation

Department of Neurological Science, Second University of Naples, Piazza Miraglia 2, Naples 80131, Italy

Oncology Reference Center of Basilicata, IRCCS-CROB, Rionero in Vulture (PZ), Italy

Opera CRO Scientific Advisor Board, Genoa, Italy

Institute of Biostructure and Bioimaging, National Research Council, Naples, Italy

Department of Biochemistry and Biophysics F.Cedrangolo, Second University of Naples, Naples, Italy

Institute Hermitage Capodimonte, Naples, Italy

Details ▼

Impact factor: 1.495, 5-year impact factor: 1.406

Paper type: Journal Article,

Keywords: Bdnf Polymorphism, Brain Atrophy, Multiple Sclerosis, Brain Derived Neurotrophic Factor, Methionine, Valine, Adult, Article, Brain Size, Cerebrospinal Fluid Examination, Clinical Article, Controlled Study, Demyelination, Disease Activity, Female, Genetic Polymorphism, Genotype, Gray Matter, Human, Neuroimaging, Nuclear Magnetic Resonance Imaging, Spectral Sensitivity, White Matter, Adolescent, Analysis Of Variance, Brain-Derived Neurotrophic Factor, Case-Control Studies, Disability Evaluation, Dna Mutational Analysis, Gene Frequency, Image Processing, Computer-Assisted, Middle Aged, Single Nucleotide, Regression Analysis, Young Adult, Brain Pathology, Brain-Derived Neurotrophic Factor Genetics, Methionine Genetics, Multiple Sclerosis Genetics Pathology, Single Nucleotide Genetics, Valine Genetics,

Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-79551599360&partnerID=40&md5=59658e7d325c8274d56303128354fb36

References ▼

Trapp, B.D., Peterson, J.W., Ransohoff, R.M., Rudick, R., Mork, S., Bo, L., Axonal transection in the lesions of multiple sclerosis (1998) N Engl J Med, 338, pp. 278-285. , 1:STN:280:DyaK1c%2Fpt1SksA%3D%3D 10.1056/NEJM199801293380502 944540

Peterson, J.W., Bo, L., Mork, S., Chang, A., Trapp, B.D., Transected neuritis, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions (2001) Ann Neurol, 50, pp. 389-400. , 1:STN:280:DC%2BD3MrhtFCnug%3D%3D 10.1002/ana.1123 11558796

Kidd, D., Barkof, F., McConnell, R., Algra, P.R., Allen, I.V., Revesz, T., Cortical lesions in multiple sclerosis (1999) Brain, 122, pp. 17-26. , 10.1093/brain/122.1.17 10050891

Frohman, E.M., Racke, M.K., Raine, C.S., Multiple sclerosis-the plaque and its pathogenesis (2006) N Engl J Med, 354 (9), pp. 942-955. , 1:CAS:528:DC%2BD28XitVertLc%3D 10.1056/NEJMra052130 16510748

Kutzelnigg, A., Lucchinetti, C.F., Stadelmann, C., Bruck, W., Rauschka, H., Bergmann, M., Cortical demyelination and diffuse white matter injury in multiple sclerosis (2005) Brain, 128 (PART 11), pp. 2705-2712. , 10.1093/brain/awh641 16230320

Bjartmar, C., Kinkel, R.P., Kidd, G., Rudick, R.A., Trapp, B.D., Axonal loss in normal-appearing white matter in a patient with acute MS (2001) Neurology, 57 (7), pp. 1248-1252. , 1:STN:280:DC%2BD3MrksVyhtw%3D%3D 11591844

Dutta, R., McDonough, J., Yin, X., Peterson, J., Chang, A., Torres, T., Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients (2006) Ann Neurol, 59 (3), pp. 478-489. , 1:CAS:528:DC%2BD28XjtV2ltr4%3D 10.1002/ana.20736 16392116

Lucchinetti, C.F., Bruck, W., Lassmann, H., Evidence for pathogenic heterogeneity in multiple sclerosis (2004) Ann Neurol, 56 (2), p. 308. , 10.1002/ana.20182 15293289

Tedeschi, G., Lavorgna, L., Russo, P., Prinster, A., Dinacci, D., Savettieri, G., Brain atrophy and lesion load in a large population of patients with multiple sclerosis (2005) Neurology, 65 (2), pp. 280-285. , 1:STN:280:DC%2BD2MzosFyrsw%3D%3D 10.1212/01.wnl.0000168837.87351.1f 16043800

De Stefano, N., Iannucci, G., Sormani, M.P., Guidi, L., Bartolozzi, M.L., Comi, G., MR correlates of cerebral atrophy in patients with multiple sclerosis (2002) J Neurol, 249 (8), pp. 1072-1077. , 10.1007/s00415-002-0790-5 12195457

De Stefano, N., Matthews, P.M., Filippi, M., Agosta, F., De Luca, M., Bartolozzi, M.L., Evidence of early cortical atrophy in MS: Relevance to white matter changes and disability (2003) Neurology, 60 (7), pp. 1157-1162. , 12682324

Pittock, S.J., Lucchinetti, C.F., The pathology of MS: New insights and potential clinical applications (2007) Neurologist, 13 (2), pp. 45-56. , 10.1097/01.nrl.0000253065.31662.37 17351524 (Review)

Ge, Y., Grossman, R.I., Udupa, J.K., Babb, J.S., Nyul, L.G., Kolson, D.L., Brain atrophy in relapsing-remitting multiple sclerosis: Fractional volumetric analysis of gray matter and white matter (2001) Radiology, 220 (3), pp. 606-610. , 1:STN:280:DC%2BD3MvotlaitQ%3D%3D 10.1148/radiol.2203001776 11526256

Bermel, R.A., Bakshi, R., The measurement and clinical relevance of brain atrophy in multiple sclerosis (2006) Lancet Neurol, 5 (2), pp. 158-170. , 10.1016/S1474-4422(06)70349-0 16426992 (Review)

Tedeschi, G., Dinacci, D., Comerci, M., Lavorgna, L., Savettieri, G., Quattrone, A., Brain atrophy evolution and lesion load accrual in multiple sclerosis: A 2-year follow-up study (2008) Mult Scler, 79 (11), pp. 1236-1244

Ramagopalan, S.V., Ebers, G.C., Genes for multiple sclerosis (2008) Lancet, 371 (9609), pp. 283-285. , 10.1016/S0140-6736(08)60145-2 18294983

Ebers, G.C., Environmental factors and multiple sclerosis (2008) Lancet Neurol, 7 (3), pp. 268-277. , 10.1016/S1474-4422(08)70042-5 18275928

Martínez, A., Alvarez-Lafuente, R., Mas, A., Bartolomé, M., García-Montojo, M., De Las Heras, V., Environment-gene interaction in multiple sclerosis: Human herpesvirus 6 and MHC2TA (2007) Hum Immunol, 68 (8), pp. 685-689. , 10.1016/j.humimm.2007.05.005 17678724

Poo, M.M., Neurotrophins as synaptic modulators (2001) Nat Rev Neurosci, 2 (1), pp. 24-32. , 1:CAS:528:DC%2BD3MXisl2ru7s%3D 10.1038/35049004 11253356

Ockel, M., Lewin, G.R., Barde, Y.A., In vivo effects of neurotrophin-3 during sensory neurogenesis (1996) Development, 122 (1), pp. 301-307. , 1:CAS:528:DyaK28XnvVWrtA%3D%3D 8565842

Hofer, M., Pagliusi, S.R., Hohn, A., Leibrock, J., Barde, Y.A., Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain (1990) EMBO J, 9 (8), pp. 2459-2464. , 1:CAS:528:DyaK3cXlvVGgsro%3D 2369898

Tyler, W.J., Alonso, M., Bramham, C.R., Pozzo-Miller, L.D., From acquisition to consolidation: On the role of brain-derived neurotrophic factor signaling in hippocampal-dependent learning (2002) Learn Mem, 9 (5), pp. 224-237. , 10.1101/lm.51202 12359832

Pruunsild, P., Kazantseva, A., Aid, T., Palm, K., Timmusk, T., Dissecting the human BDNF locus: Bidirectional transcription, complex splicing, and multiple promoters (2007) Genomics, 90 (3), pp. 397-406. , 1:CAS:528:DC%2BD2sXosFegsrc%3D 10.1016/j.ygeno.2007.05.004 17629449

Bramham, C.R., Messaoudi, E., BDNF function in adult synaptic plasticity: The synaptic consolidation hypothesis (2005) Prog Neurobiol, 76 (2), pp. 99-125. , 1:CAS:528:DC%2BD2MXpvFemu7s%3D 10.1016/j.pneurobio.2005.06.003 16099088

Zhou, X.F., Song, X.Y., Zhong, J.H., Barati, S., Zhou, F.H., Johnson, S.M., Distribution and localization of probrain-derived neurotrophic factor-like immunoreactivity in the peripheral and central nervous system of the adult rat (2004) J Neurochem, 91 (3), pp. 704-715. , 1:CAS:528:DC%2BD2cXpsFelt7o%3D 10.1111/j.1471-4159.2004.02775.x 15485500

Kojima, M., Takei, N., Numakawa, T., Ishikawa, Y., Suzuki, S., Matsumoto, T., Biological characterization and optical imaging of brain-derived neurotrophic factor-green fluorescent protein suggest an activity-dependent local release of brain-derived neurotrophic factor in neurites of cultured hippocampal neurons (2001) J Neurosci Res, 64 (1), pp. 1-10. , 1:CAS:528:DC%2BD3MXisFWltbs%3D 10.1002/jnr.1080 11276045

Kerschensteiner, M., Gallmeier, E., Behrens, L., Leal, V.V., Misgeld, T., Klinkert, W.E., Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: A neuroprotective role of inflammation? (1999) J Exp Med, 189 (5), pp. 865-870. , 1:CAS:528:DyaK1MXhsF2ju7k%3D 10.1084/jem.189.5.865 10049950

Besser, M., Wank, R., Cutting edge: Clonally restricted production of the neurotrophins brain-derived neurotrophic factor and neurotrophin-3 mRNA by human immune cells and Th1/Th2-polarized expression of their receptors (1999) J Immunol, 62 (11), pp. 6303-6306

Braun, A., Lommatzsch, M., Mannsfeldt, A., Neuhaus-Steinmetz, U., Fischer, A., Schnoy, N., Cellular sources of enhanced brain-derived neurotrophic factor production in a mouse model of allergic inflammation (1999) Am J Respir Cell Mol Biol, 21 (4), pp. 537-546. , 1:CAS:528:DyaK1MXmvFeltLk%3D 10502564

Stadelmann, C., Kerschensteiner, M., Misgeld, T., Brück, W., Hohlfeld, R., Lassmann, H., BDNF and gp145trkB in multiple sclerosis brain lesions: Neuroprotective interactions between immune and neuronal cells? (2002) Brain, 125 (PART 1), pp. 75-85. , 10.1093/brain/awf015 11834594

Chen, Z.Y., Patel, P.D., Sant, G., Meng, C.X., Teng, K.K., Hempstead, B.L., Lee, F.S., Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons (2004) J Neurosci, 24 (18), pp. 4401-4411. , 1:CAS:528:DC%2BD2cXktFCjtLg%3D 10.1523/JNEUROSCI.0348-04.2004 15128854

Egan, M.F., Kojima, M., Callicott, J.H., Goldberg, T.E., Kolachana, B.S., Bertolino, A., The BDNF Val66Met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function (2003) Cell, 112 (2), pp. 257-269. , 1:CAS:528:DC%2BD3sXpvVemug%3D%3D 10.1016/S0092-8674(03)00035-7 12553913

Stern, A.J., Savostyanova, A.A., Goldman, A., Barnett, A.S., Van Der Veen, J.W., Callicott, J.H., Impact of the brain-derived neurotrophic factor Val66Met polymorphism on levels of hippocampal N-acetylaspartate assessed by magnetic resonance spectroscopic imaging at 3 Tesla (2008) Biol Psychiatr, 64 (10), pp. 856-862. , 1:CAS:528:DC%2BD1cXht12gu7jI 10.1016/j.biopsych.2008.07.009

Pezawas, L., Verchinski, B.A., Mattay, V.S., Callicott, J.H., Kolachana, B.S., Straub, R.E., The brainderived neurotrophic factor Val66Met polymorphism and variation in human cortical morphology (2004) J Neurosci, 24 (45), pp. 10099-10102. , 1:CAS:528:DC%2BD2cXhtVeqtLfK 10.1523/JNEUROSCI.2680-04.2004 15537879

Bueller, J.A., Aftab, M., Sen, S., Gomez-Hassan, D., Burmeister, M., Zubieta, J.K., BDNF Val66Met allele is associated with reduced hippocampal volume in healthy subjects (2006) Biol Psychiatr, 59 (9), pp. 812-815. , 1:CAS:528:DC%2BD28XjsFOnt78%3D 10.1016/j.biopsych.2005.09.022

Nemoto, K., Ohnishi, T., Mori, T., Moriguchi, Y., Hashimoto, R., Asada, T., The Val66Met polymorphism of the brain-derived neurotrophic factor gene affects age-related brain morphology (2006) Neurosci Lett, 397 (12), pp. 25-29. , 1:CAS:528:DC%2BD28Xit1Ois7c%3D 10.1016/j.neulet.2005.11.067 16388901

Takahashi, T., Suzuki, M., Tsunoda, M., Kawamura, Y., Takahashi, N., Tsuneki, H., Association between the brain-derived neurotrophic factor Val66Met polymorphism and brain morphology in a Japanese sample of schizophrenia and healthy comparisons (2008) Neurosci Lett, 435 (1), pp. 34-39. , 1:CAS:528:DC%2BD1cXktVCksbs%3D 10.1016/j.neulet.2008.02.004 18325670

Sublette, M.E., Baca-Garcia, E., Parsey, R.V., Oquendo, M.A., Rodrigues, S.M., Galfalvy, H., Effect of BDNF Val66Met polymorphism on age-related amygdala volume changes in healthy subjects (2008) Prog Neuropsychopharmacol Biol Psychiatr, 32 (7), pp. 1652-1655. , 1:CAS:528:DC%2BD1cXhtFartLjF 10.1016/j.pnpbp.2008.06.009

Hariri, A.R., Goldberg, T.E., Mattay, V.S., Kolachana, B.S., Callicott, J.H., Egan, M.F., Weinberger, D.R., Brainderived neurotrophic factor Val66Met polymorphism affects human memory-related hippocampal activity and predicts memory performance (2003) J Neurosci, 23 (17), pp. 6690-6694. , 1:CAS:528:DC%2BD3sXmtFensbg%3D 12890761

Miyajima, F., Ollier, W., Mayes, A., Jackson, A., Thacker, N., Rabbitt, P., Pendleton, N., Payton, A., Brain-derived neurotrophic factor polymorphism Val66Met influences cognitive abilities in the elderly (2008) Genes Brain Behav, 7 (4), pp. 411-417. , 1:CAS:528:DC%2BD1cXnvVOitro%3D 10.1111/j.1601-183X.2007.00363.x 17973920 (Epub 2007 Oct)

Frodl, T., Schüle, C., Schmitt, G., Born, C., Baghai, T., Zill, P., Bottlender, R., Meisenzahl, E.M., Association of the brain-derived neurotrophic factor Val66Met polymorphism with reduced hippocampal volumes in major depression (2007) Arch Gen Psychiatr, 64 (4), pp. 410-416. , 1:CAS:528:DC%2BD2sXltlWisrs%3D 10.1001/archpsyc.64.4.410 17404118

Mirakhur, A., Moorhead, T.W., Stanfield, A.C., McKirdy, J., Sussmann, J.E., Hall, J., Lawrie, S.M., McIntosh, A.M., Changes in gyrification over 4 years in bipolar disorder and their association with the brain-derived neurotrophic factor valine(66) methionine variant (2009) Biol Psychiatr, 66, pp. 293-297. , 1:CAS:528:DC%2BD1MXotF2nsro%3D 10.1016/j.biopsych.2008.12.006

Ho, B.C., Milev, P., O'Leary, D.S., Librant, A., Andreasen, N.C., Wassink, T.H., Cognitive and magnetic resonance imaging brain morphometric correlates of brain-derived neurotrophic factor Val66Met gene polymorphism in patients with schizophrenia and healthy volunteers (2006) Arch Gen Psychiatr, 63 (7), pp. 731-740. , 1:CAS:528:DC%2BD28XnsFGls74%3D 10.1001/archpsyc.63.7.731 16818862

Ho, B.C., Andreasen, N.C., Dawson, J.D., Wassink, T.H., Association between brain-derived neurotrophic factor Val66Met gene polymorphism and progressive brain volume changes in schizophrenia (2007) Am J Psychiatr, 164 (12), pp. 1890-1899. , 10.1176/appi.ajp.2007.05111903 18056245

Weinstock-Guttman, B., Zivadinov, R., Tamaño-Blanco, M., Abdelrahman, N., Badgett, D., Durfee, J., Hussein, S., Immune cell BDNF secretion is associated with white matter volume in multiple sclerosis (2007) J Neuroimmunol, 188 (12), pp. 167-174. , 1:CAS:528:DC%2BD2sXotlWqtbw%3D 10.1016/j.jneuroim.2007.06.003 17602759 (Epub 2007 Jun 28)

Liguori, M., Fera, F., Patitucci, A., Manna, I., Condino, F., Valentino, P., A longitudinal observation of brain-derived neurotrophic factor mRNA levels in patients with relapsing-remitting multiple sclerosis (2008) Brain Res, 1256, pp. 123-128. , 10.1016/j.brainres.2008.11.047 19071096

Zivadinov, R., Weinstock-Guttman, B., Benedict, R., Tamaño-Blanco, M., Hussein, S., Abdelrahman, N., Preservation of gray matter volume in multiple sclerosis patients with the Met allele of the rs6265 (Val66Met) SNP of brain-derived neurotrophic factor (2007) Hum Mol Genet, 16 (22), pp. 2659-2668. , 1:CAS:528:DC%2BD2sXht1aksbjI 10.1093/hmg/ddm189 17656372 (Epub 2007 Jul 26)

Blanco, Y., Gómez-Choco, M., Arostegui, J.L., Casanova, B., Martínez-Rodríguez, J.E., Boscá, I., Munteis, E., Saiz, A., No association of the Val66Met polymorphism of brain-derived neurotrophic factor BDNF) to multiple sclerosis (2006) Neurosci Lett, 396 (3), pp. 217-219. , 1:CAS:528:DC%2BD28XitVCqtr8%3D 10.1016/j.neulet.2005.11.032 16356643 (Epub 2005 Dec 13)

Lindquist, S., Schott, B.H., Ban, M., Compston, D.A., Sawcer, S., Sailer, M., The BDNF-Val66Met polymorphism: Implications for susceptibility to multiple sclerosis and severity of disease (2005) J Neuroimmunol, 167 (12), pp. 183-185. , 1:CAS:528:DC%2BD2MXpvFarsrY%3D 10.1016/j.jneuroim.2005.06.008 16046000

Alfano, B., Brunetti, A., Larobina, M., Quarantelli, M., Tedeschi, E., Ciarmiello, A., Automated segmentation and measurement of global white matter lesion volume in patients with multiple sclerosis (2000) J Magn Reson Imaging, 12, pp. 799-807. , 1:STN:280:DC%2BD3M7htVaktA%3D%3D 10.1002/1522-2586(200012)12:6<799:: AID-JMRI2>3.0.CO

Lanzillo, R., Prinster, A., Scarano, V., Liuzzi, R., Coppola, G., Florio, C., Neuropsychological assessment, quantitative MRI and ApoE gene polymorphisms in a series of MS patients treated with IFN β-1b (2006) J Neurol Sci, 245 (12), pp. 141-145. , 1:CAS:528:DC%2BD28Xlt1CltL4%3D 10.1016/j.jns.2005.08.023 16626758 (Epub 2006 Apr 19)

Quarantelli, M., Ciarmiello, A., Morra, V.B., Orefice, G., Larobina, M., Lanzillo, R., Brain tissue volume changes in relapsing-remitting multiple sclerosis: Correlation with lesion load (2003) Neuroimage, 18 (2), pp. 360-366. , 10.1016/S1053-8119(02)00018-6 12595189

Alfano, B., Quarantelli, M., Brunetti, A., Larobina, M., Covelli, E.M., Tedeschi, E., Reproducibility of intracranial volume measurement by unsupervised multispectral brain segmentation (1998) Magn Reson Med, 39 (3), pp. 497-499. , 1:STN:280:DyaK1c7lvVeksA%3D%3D 10.1002/mrm.1910390321 9498607

Kurtzke, J.F., Rating neurological impairment in multiple sclerosis: An expanded disability status scale (EDSS) (1983) Neurology, 33, pp. 1444-1452. , 1:STN:280:DyaL2c%2FktValsQ%3D%3D 6685237

Pelletier, D., Garrison, K., Henry, R., Measurement of whole-brain atrophy in multiple sclerosis (2004) J Neuroimaging, 14 (3 SUPPL.), pp. 11S-19S. , 10.1111/j.1552-6569.2004.tb00274.x 15228755 (Review)

Cheng, C.Y., Hong, C.J., Yu, Y.W., Chen, T.J., Wu, H.C., Tsai, S.J., Brain-derived neurotrophic factor (Val66Met) genetic polymorphism is associated with substance abuse in males (2005) Brain Res Mol Brain Res, 140 (12), pp. 86-90. , 1:CAS:528:DC%2BD2MXhtFSitr7N 10.1016/j.molbrainres.2005.07.008 16109452 (Epub 2005 Aug 18)

Trapp, B. D., Peterson, J. W., Ransohoff, R. M., Rudick, R., Mork, S., Bo, L., Axonal transection in the lesions of multiple sclerosis (1998) N Engl J Med, 338, pp. 278-285. , 1: STN: 280: DyaK1c%2Fpt1SksA%3D%3D 10. 1056/NEJM199801293380502 944540

Peterson, J. W., Bo, L., Mork, S., Chang, A., Trapp, B. D., Transected neuritis, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions (2001) Ann Neurol, 50, pp. 389-400. , 1: STN: 280: DC%2BD3MrhtFCnug%3D%3D 10. 1002/ana. 1123 11558796

Frohman, E. M., Racke, M. K., Raine, C. S., Multiple sclerosis-the plaque and its pathogenesis (2006) N Engl J Med, 354 (9), pp. 942-955. , 1: CAS: 528: DC%2BD28XitVertLc%3D 10. 1056/NEJMra052130 16510748

Pittock, S. J., Lucchinetti, C. F., The pathology of MS: New insights and potential clinical applications (2007) Neurologist, 13 (2), pp. 45-56. , 10. 1097/01. nrl. 0000253065. 31662. 37 17351524 (Review)

Bermel, R. A., Bakshi, R., The measurement and clinical relevance of brain atrophy in multiple sclerosis (2006) Lancet Neurol, 5 (2), pp. 158-170. , 10. 1016/S1474-4422 (06) 70349-0 16426992 (Review)

Ramagopalan, S. V., Ebers, G. C., Genes for multiple sclerosis (2008) Lancet, 371 (9609), pp. 283-285. , 10. 1016/S0140-6736 (08) 60145-2 18294983

Ebers, G. C., Environmental factors and multiple sclerosis (2008) Lancet Neurol, 7 (3), pp. 268-277. , 10. 1016/S1474-4422 (08) 70042-5 18275928

Mart nez, A., Alvarez-Lafuente, R., Mas, A., Bartolom, M., Garc a-Montojo, M., De Las Heras, V., Environment-gene interaction in multiple sclerosis: Human herpesvirus 6 and MHC2TA (2007) Hum Immunol, 68 (8), pp. 685-689. , 10. 1016/j. humimm. 2007. 05. 005 17678724

Poo, M. M., Neurotrophins as synaptic modulators (2001) Nat Rev Neurosci, 2 (1), pp. 24-32. , 1: CAS: 528: DC%2BD3MXisl2ru7s%3D 10. 1038/35049004 11253356

Tyler, W. J., Alonso, M., Bramham, C. R., Pozzo-Miller, L. D., From acquisition to consolidation: On the role of brain-derived neurotrophic factor signaling in hippocampal-dependent learning (2002) Learn Mem, 9 (5), pp. 224-237. , 10. 1101/lm. 51202 12359832

Bramham, C. R., Messaoudi, E., BDNF function in adult synaptic plasticity: The synaptic consolidation hypothesis (2005) Prog Neurobiol, 76 (2), pp. 99-125. , 1: CAS: 528: DC%2BD2MXpvFemu7s%3D 10. 1016/j. pneurobio. 2005. 06. 003 16099088

Zhou, X. F., Song, X. Y., Zhong, J. H., Barati, S., Zhou, F. H., Johnson, S. M., Distribution and localization of probrain-derived neurotrophic factor-like immunoreactivity in the peripheral and central nervous system of the adult rat (2004) J Neurochem, 91 (3), pp. 704-715. , 1: CAS: 528: DC%2BD2cXpsFelt7o%3D 10. 1111/j. 1471-4159. 2004. 02775. x 15485500

Chen, Z. Y., Patel, P. D., Sant, G., Meng, C. X., Teng, K. K., Hempstead, B. L., Lee, F. S., Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons (2004) J Neurosci, 24 (18), pp. 4401-4411. , 1: CAS: 528: DC%2BD2cXktFCjtLg%3D 10. 1523/JNEUROSCI. 0348-04. 2004 15128854

Egan, M. F., Kojima, M., Callicott, J. H., Goldberg, T. E., Kolachana, B. S., Bertolino, A., The BDNF Val66Met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function (2003) Cell, 112 (2), pp. 257-269. , 1: CAS: 528: DC%2BD3sXpvVemug%3D%3D 10. 1016/S0092-8674 (03) 00035-7 12553913

Stern, A. J., Savostyanova, A. A., Goldman, A., Barnett, A. S., Van Der Veen, J. W., Callicott, J. H., Impact of the brain-derived neurotrophic factor Val66Met polymorphism on levels of hippocampal N-acetylaspartate assessed by magnetic resonance spectroscopic imaging at 3 Tesla (2008) Biol Psychiatr, 64 (10), pp. 856-862. , 1: CAS: 528: DC%2BD1cXht12gu7jI 10. 1016/j. biopsych. 2008. 07. 009

Bueller, J. A., Aftab, M., Sen, S., Gomez-Hassan, D., Burmeister, M., Zubieta, J. K., BDNF Val66Met allele is associated with reduced hippocampal volume in healthy subjects (2006) Biol Psychiatr, 59 (9), pp. 812-815. , 1: CAS: 528: DC%2BD28XjsFOnt78%3D 10. 1016/j. biopsych. 2005. 09. 022

Sublette, M. E., Baca-Garcia, E., Parsey, R. V., Oquendo, M. A., Rodrigues, S. M., Galfalvy, H., Effect of BDNF Val66Met polymorphism on age-related amygdala volume changes in healthy subjects (2008) Prog Neuropsychopharmacol Biol Psychiatr, 32 (7), pp. 1652-1655. , 1: CAS: 528: DC%2BD1cXhtFartLjF 10. 1016/j. pnpbp. 2008. 06. 009

Hariri, A. R., Goldberg, T. E., Mattay, V. S., Kolachana, B. S., Callicott, J. H., Egan, M. F., Weinberger, D. R., Brainderived neurotrophic factor Val66Met polymorphism affects human memory-related hippocampal activity and predicts memory performance (2003) J Neurosci, 23 (17), pp. 6690-6694. , 1: CAS: 528: DC%2BD3sXmtFensbg%3D 12890761

Frodl, T., Sch le, C., Schmitt, G., Born, C., Baghai, T., Zill, P., Bottlender, R., Meisenzahl, E. M., Association of the brain-derived neurotrophic factor Val66Met polymorphism with reduced hippocampal volumes in major depression (2007) Arch Gen Psychiatr, 64 (4), pp. 410-416. , 1: CAS: 528: DC%2BD2sXltlWisrs%3D 10. 1001/archpsyc. 64. 4. 410 17404118

Ho, B. C., Milev, P., O'Leary, D. S., Librant, A., Andreasen, N. C., Wassink, T. H., Cognitive and magnetic resonance imaging brain morphometric correlates of brain-derived neurotrophic factor Val66Met gene polymorphism in patients with schizophrenia and healthy volunteers (2006) Arch Gen Psychiatr, 63 (7), pp. 731-740. , 1: CAS: 528: DC%2BD28XnsFGls74%3D 10. 1001/archpsyc. 63. 7. 731 16818862

Ho, B. C., Andreasen, N. C., Dawson, J. D., Wassink, T. H., Association between brain-derived neurotrophic factor Val66Met gene polymorphism and progressive brain volume changes in schizophrenia (2007) Am J Psychiatr, 164 (12), pp. 1890-1899. , 10. 1176/appi. ajp. 2007. 05111903 18056245

Blanco, Y., G mez-Choco, M., Arostegui, J. L., Casanova, B., Mart nez-Rodr guez, J. E., Bosc, I., Munteis, E., Saiz, A., No association of the Val66Met polymorphism of brain-derived neurotrophic factor BDNF) to multiple sclerosis (2006) Neurosci Lett, 396 (3), pp. 217-219. , 1: CAS: 528: DC%2BD28XitVCqtr8%3D 10. 1016/j. neulet. 2005. 11. 032 16356643 (Epub 2005 Dec 13)

Kurtzke, J. F., Rating neurological impairment in multiple sclerosis: An expanded disability status scale (EDSS) (1983) Neurology, 33, pp. 1444-1452. , 1: STN: 280: DyaL2c%2FktValsQ%3D%3D 6685237

Cheng, C. Y., Hong, C. J., Yu, Y. W., Chen, T. J., Wu, H. C., Tsai, S. J., Brain-derived neurotrophic factor (Val66Met) genetic polymorphism is associated with substance abuse in males (2005) Brain Res Mol Brain Res, 140 (12), pp. 86-90. , 1: CAS: 528: DC%2BD2MXhtFSitr7N 10. 1016/j. molbrainres. 2005. 07. 008 16109452 (Epub 2005 Aug 18)

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