Export to BibTeX Export to EndNoteBrain atrophy evolution and lesion load accrual in multiple sclerosis: A 2-year follow-up study (104 views) (PDF restricted 84 views)
Tedeschi G, Dinacci D, Comerci M, Lavorgna L, Savettieri G, Quattrone A, Livrea P, Patti F, Morra VB, Servillo G, Orefice G, Paciello M, Prinster A, Coniglio G, Bonavita S, Di Costanzo A, Bellacosa A, Valentino P, Quarantelli M, Brunetti A, Salemi G, D'Amelio M, Simone I, Salvatore M, Bonavita V, Alfano B
Mult Scler (ISSN: 1352-4585, 1477-0970, 1352-4585linking), 2009 Feb; 15(2): 204-211.
Abstract
Background To investigate in a large cohort of patients with multiple sclerosis (MS), lesion load and atrophy evolution, and the relationship between clinical and magnetic resonance imaging (MRI) correlates of disease progression. Methods Two hundred and sixty-seven patients with MS were studied at baseline and two years later using the same MRI protocol. Abnormal white matter fraction, normal appearing white matter fraction, global white matter fraction, gray matter fraction and whole brain fraction, T2-hyperintense, and T1-hypointense lesions were measured at both time points. Results The majority of patients were clinically stable, whereas MRI-derived brain tissue fractions were significantly different after 2 years. The correlation between MRI data at baseline and their variation during the follow-up showed that lower basal gray matter atrophy was significantly related with higher progression of gray matter atrophy during follow-up. The correlation between MRI parameters and disease duration showed that gray matter atrophy rate decreased with increasing disease duration, whereas the rate of white matter atrophy had a constant pattern. Lower basal gray matter atrophy was associated with increased probability of developing gray matter atrophy at follow-up, whereas gray matter atrophy progression over 2 years and new T2 lesion load were risk factors for whole brain atrophy progression. Conclusions In MS, brain atrophy occurs even after a relatively short period of time and in patients with limited progression of disability. Short-term brain atrophy progression rates differ across tissue compartments, as gray matter atrophy results more pronounced than white matter atrophy and appears to be a early phenomenon in the MS-related disease progression. Multiple Sclerosis 2009; 15: 204-211. http://msj.sagepub.com
Affiliations ▼
*** IBB - CNR Affiliation
Department of Neurological Sciences, Second University of Naples, Piazza Miraglia 2, 80138 Naples, Italy
Institute Hermitage Capodimonte, Naples, Italy
Institute of Biostructure and Bioimaging, National Research Council, Naples, Italy
istituto di biostrutture e bioimmagini
Univ Naples 2, Dept Neurol Sci, I-80138 Naples, Ita |
Details ▼
Impact factor: 4.863, 5-year impact factor: 4.276
Paper type: Journal Article,
Keywords: Atrophy, Mri, Multiple Sclerosis, T2 Lesions, Adolescent, Adult, Aged, Article, Brain Atrophy, Clinical Feature, Cohort Analysis, Controlled Study, Disability, Disease Duration, Disease Exacerbation, Female, Follow Up, Gray Matter, Human, Image Analysis, Major Clinical Study, Nuclear Magnetic Resonance Imaging, Risk Factor, White Matter, Cross-Sectional Studies, Disease Progression, Follow-Up Studies, Logistic Models, Middle Aged, Chronic Progressive, Relapsing-Remitting, Multivariate Analysis, Severity Of Illness Index, Young Adult, Brain Pathology, Chronic Progressive Epidemiology Pathology, Relapsing-Remitting Epidemiology Pathology,
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-59349101209&partnerID=40&md5=4aa6ede6e9b707444a5298922398bbe1 |
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Rudick, R. A., Lee, J. C., Simon, J., Fisher, E., Significance of T2 lesions in multiple sclerosis: A 13-year longitudinal study (2006) Ann Neurol, 60, pp. 236-242
Chard, D. T., Griffin, C. M., Rashid, W., Progressive grey matter atrophy in clinically early relapsing-remitting multiple sclerosis (2004) Mult Scler, 10, pp. 387-391
Richert, N. D., Howard, T., Frank, J. A., Relationship between inflammatory lesions and cerebral atrophy in multiple sclerosis (2006) Neurology, 66, pp. 551-556
Dalton, C. M., Chard, D. T., Davies, G. R., Early development of multiple sclerosis is associated with progressive grey matter atrophy in patients presenting with clinically isolated syndromes (2004) Brain, 127, pp. 1101-1107
Fisniku, L. K., Chard, D. T., Jackson, J. S., Gray matter atrophy is related to long-term disability in multiple sclerosis (2008) Ann Neurol, 64, pp. 247-254
McDonald, W. I., Compston, A., Edan, G., Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the diagnosis of multiple sclerosis (2001) Ann Neurol, 50, pp. 121-127
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Cutter, G. R., Baier, M. L., Rudick, R. A., Development of a multiple sclerosis functional composite as a clinical trial outcome measure (1999) Brain, 122, pp. 871-882
Pittock, S. J., Mayr, W. T., McClelland, R. L., Change in MS-related disability in a population-based cohort: A 10-year follow-up study (2004) Neurol, 62, pp. 51-59
Rocca, M. A., Filippi, M., Functional MRI in multiple sclerosis (2007) J Neuroimaging, (17 SUPPL.), pp. 36S-41S
Rocca, M. A., Pagani, E., Ghezzi, A., Functional cortical changes in patients with multiple sclerosis and non-specific findings on conventional magnetic resonance imaging scans of the brain (2003) Neuroimage, 19, pp. 826-836
Mezzapesa, D. M., Rocca, M. A., Rodegher, M., Comi, G., Filippi, M., Functional cortical changes of the sensorimotor network are associated with clinical recovery in multiple sclerosis (2008) Hum Brain Mapp, 29, pp. 562-567
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