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Query: Extended Site:
Phenotyping of murine models by preclinical imaging.
Contact person: Sara Gargiulo, sara.gargiuloibb.cnr.it


Description ▼
Several techniques for structural and functional tomographic imaging are utilized in the molecular imaging research field to characterize animal models. Preclinical imaging has emerged as an important non-invasive tool to facilitate anatomical and functional phenotyping in small rodents for studying normal pattern and models of human disease. Modern biomedical research is rapidly evolving to include sophisticated imaging analysis like high resolution X-ray based techniques, nuclear imaging technologies, ultrasound biomicroscopy or magnetic resonance. Over the last years these modalities have been improved to address the needs of researchers to analyse living animals in longitudinal studies. Moreover, the phenotyping strategies of murine models through imaging aim to promote multidisciplinary translational research by assisting in the characterization of genetically modified animal models of human diseases. We showed that morpho-functional imaging methods have strengthened the options of in vivo visualization of cancer-related processes over time, evaluation of metabolism, body composition and bone mineral density, cardiovascular phenotyping and neurological studies in mouse models.

Actors ▼
Matteo Gramanzini, matteo.gramanziniibb.cnr.it
Sara Gargiulo, sara.gargiuloibb.cnr.it
Marcello Mancini, marcello.mancini58gmail.com
Giuseppe Palma, giuseppe.palmaibb.cnr.it
Adelaide Greco, adegrecounina.it
Arturo Brunetti, adegrecounina.it

Keywords ▼
Phenotyping, murine models, preclinical imaging, morpho functional imaging,

Research Areas ▼
Preclinical Imaging, Other Diseases, 

Figures ▼


DEXA in mice: body composition in CbX7 knockout mouse.


Ultrasound Biomicroscopy in mice: 3D volume rendering of mouse thyroid.

High resolution computed tomography in mice: 3D maximum intensity projection of mouse skeleton.


High resolution computed tomography in mice: 3D volume rendering of mouse  lungs with melanoma metastasis.




Selected Papers ▼

Papers

Mancini M, Greco A, Tedeschi E, Palma G, Ragucci M, Bruzzone MG, Coda AR, Torino E, Scotti A, Zucca I, Salvatore M. Head and Neck Veins of the Mouse. A Magnetic Resonance, Micro Computed Tomography and High Frequency Color Doppler Ultrasound Study. PLoS One. 2015;10(6):e0129912.

Greco A, Coda AR, Albanese S, Ragucci M, Liuzzi R, Auletta L, Gargiulo S, Lamagna F, Salvatore M, Mancini M. High-Frequency Ultrasound for the Study of Early Mouse Embryonic Cardiovascular System. Reprod Sci. 2015; 22(12):1649-55.

S. Gargiulo*, M. Gramanzini*, R. Megna, A. Greco, S. Albanese, C. Manfredi, A. Brunetti, “Evaluation of growth patterns and body composition in C57BL/6J mice using Dual Energy X-Ray Absorptiometry”, Biomed Research International 2014 10 July; http://dx.doi.org/10.1155/2014/253067, * equal contribution

Forzati F, Federico A, Pallante P, Colamaio M, Esposito F, Sepe R, Gargiulo S, Luciano A, Arra C, Palma G, Bon G, Bucher S, Falcioni R, Brunetti A, Battista S, Fedele M, Fusco A. CBX7 gene expression plays a negative role in adipocyte cell growth and differentiation. Biol Open. 2014 Sep 4;3(9):871-9. doi: 10.1242/bio.20147872.


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* Primary Peritoneal Clear Cell Carcinoma Versus Ovarian Carcinoma Versus Malignant Transformation of Endometriosis: A Vexing Issue (50 views)
Insabato L, Natella V, Somma A, Persico M, Camera L, Losito NS, Masone S
Int J Surg Pathol International Journal Of Surgical Pathology (ISSN: 1066-8969), 2015; 23(3): 211-216.

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1 Records (1 excluding Abstracts and Conferences).
Total impact factor: 0.961 (0.961 excluding Abstracts and Conferences).
Total 5-year impact factor: 0.98 (0.98 excluding Abstracts and Conferences).



Your bibliography query: ([btitle, keywords, abstract] PHENOTYPING)



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