|
Projects highlights
Links
|
|< < > >|
Complementary use of preclinical imaging in minipig model studiesContact person: Sara Gargiulo, sara.gargiulo ibb.cnr.itDescription ▼Improvements
in bone-implant integration are crucial in modern dental surgery. The processes
of osseointegration involve an initial mechanical interlocking between alveolar
bone and the implant body (primary implant stability) and, later, a biological
fixation through continuous bone apposition (contact osteogenesis) and
remodeling toward the implant (secondary implant stability). The introduction
of newly developed implant materials for patients care often requires the use
of preclinical models to test biocompatibility, mechanical stability and
safety. Among other possible species, minipigs are a recommended animal model
for translational research of new dental materials before clinical trials in
humans, since their bone structure and physiology are similar to that of
humans. Based on the above considerations, minipig has been selected as a large
animal model for the pivotal preclinical testing of innovative biomaterials and
implants. This model would benefit from a non-destructive imaging modality so
that mechanical and morphological endpoints can more readily be examined in the
same specimens. Currently, microcomputed tomography (μCT) is a potential candidate tool as an adjunct for biomechanical
testing and for standard histology. μCT is fast, precise and, unlike conventional
microscopic methods, does not need long time for specimen preparation and is
not limited to assessment of a restricted number of sections. High-resolution μCT allows measurements of trabecular and cortical bone and a
three-dimensional (3D) representation of bone formation at the peri-implant
region. In this way, μCT allows less use of samples necessary for both
biomechanical and morphometric studies, in accordance with the principles of
the “refinement” and “reduction” declared by Russell and Burch in 1954. In our
pilot study we examined the utility of μCT for evaluating bone-implant integration in a
minipig model, as an adjunct to conventional histomorphometry and biomechanical
testing. The performance of an
innovative hybrid nanocomposite, as a biomimetic scaffold in improving implant
primary stability in post-surgical sites, were tested. μCT increases evaluation throughput and offers the possibility for
qualitative three-dimensional recording of the bone-implant system as well as
for non-destructive evaluation of bone architecture and mineral density, in
combination with conventional analysis methods. The proposed multimodal
approach allows to improve accuracy and reproducibility for peri-implant bone
measurements and could support future investigations.
|
Actors ▼Keywords ▼Research Areas ▼Figures ▼
High resolution computed tomography in minipig: A, High-resolution μCT 3-D volume rendering
of minipig tibias with implants. B, Representative axial μCT image of
minipig tibias with implant-bone interface visualization. C, Representative
photograph of minipig tibias with implant position visualization. D-E,
High-resolution μCT 3-D volume rendering of scaffold. F, High-resolution μCT
3-D volume rendering peri-implant bone.
|
Selected Papers ▼Papers Gramanzini M*, Gargiulo S*, Zarone F, Megna R, Apicella A,
Aversa R, Salvatore M, Mancini M, Sorrentino R, Brunetti A. Combined
microcomputed tomography, biomechanical and histomorphometric analysis of the
peri-implant bone: a pilot study in minipig model. Dental Materials 2016,
doi.org/10.1016/j.dental.2016.03.025 (In
press) * equal contribution
Abstract
Gramanzini M,
Gargiulo S, Sorrentino R, Apicella A, Zarone F, Brunetti A. Micro-CT Analysis
of Peri-implant bone in minipig model. EMIM 2014, June 4-6, 2014, Stadsschouwburg
Antwerp, Belgium. |
Related Activities ▼Related Papers ▼| 18F-FDG PET uptake in the pre-Huntington disease caudate affects the time-to-onset independently of CAG expansion size (restricted access) (77 views) | | 18F-FDG PET/CT, 99mTc-MIBI, and MRI in the prediction of outcome of patients with multiple myeloma: a comparative study (restricted access) (70 views) | | 5th Annual Meeting of the International Society for Neurovascular Disease, March 27-29th, 2015 - Naples, Italy - ABSTRACT BOOK (public domain) (71 views) | | A novel antagonist of CXCR4 prevents bone marrow-derived mesenchymal stem cell-mediated osteosarcoma and hepatocellular carcinoma cell migration and invasion (restricted access) (87 views) | | A novel CXCR4-targeted near-infrared (NIR) fluorescent probe (Peptide R-NIR750) specifically detects CXCR4 expressing tumors. (public domain) (11 views) | | A novel fully integrated handheld gamma camera (restricted access) (64 views) | | A Novel Multiparametric Approach to 3D Quantitative MRI of the Brain (public domain) (88 views) | | Advances in molecular preclinical therapy mediated by imaging (public domain) (1 views) | | An EPR and voltammetric study of simple and mixed copper(II) complexes with L- or D-glutamate and L-arginate in aqueous solution (restricted access) (12 views) | | Antimicrobial activity of Lactobacillus plantarum strains isolated from different environments: a preliminary study (public domain) (1 views) | | Aptamer-mediated impairment of EGFR-integrin αvβ3 complex inhibits vasculogenic mimicry and growth of triple-negative breast cancers (public domain) (12 views) | | Assessment of scanner performance and normalization of estimated relaxation rate values (restricted access) (57 views) | | Automatic Segmentation of the Brain and Intracranial Cerebrospinal Fluid in T1-Weighted Volume MRI Scans of the Head, and Its Application to Serial Cerebral and Intracranial Volumetry (public domain) (58 views) | | BDNF Val66Met polymorphism and brain volumes in multiple sclerosis (restricted access) (60 views) | | Brain Characterization Using Normalized Quantitative Magnetic Resonance Imaging (restricted access) (56 views) | | Brain White-Matter Volume Loss and Glucose Hypometabolism Precede the Clinical Symptoms of Huntington’s Disease (public domain) (63 views) | | Chemistry of Lipid A: At the Heart of Innate Immunity (restricted access) (110 views) | | Clinical Applications of Imaging Disease Burden in Multiple Sclerosis - MRI and Advanced Imaging Techniques (restricted access) (60 views) | | Clinical Evaluation of a New Concept: Resting Myocardial Perfusion Heterogeneity Quantified by Markovian Analysis of PET Identifies Coronary Microvascular Dysfunction and Early Atherosclerosis in 1,034 Subjects (restricted access) (48 views) | | Complication Probability Models for Radiation-Induced Heart Valvular Dysfunction: Do Heart-Lung Interactions Play a Role? (public domain) (54 views) | | Copper ion interaction with the RNase catalytic site fragment of the angiogenin protein: an experimental and theoretical investigation (public domain) (1 views) | | Delayed Contrast Enhancement and Perfusable Tissue Index in Hypertrophic Cardiomyopathy: Comparison Between Cardiac MRI and PET (restricted access) (74 views) | | Design and engineering of artificial oxygen-activating metalloenzymes (public domain) (24 views) | | Designing Covalently Linked Heterodimeric Four-Helix Bundles (public domain) (22 views) | | Diffusion volume (DV) measurement in endometrial and cervical cancer: A new MRI parameter in the evaluation of the tumor grading and the risk classification (restricted access) (66 views) | | Distinct Brain Volume Changes Correlating with Clinical Stage, Disease Progression Rate, Mutation Size, and Age at Onset Prediction as Early Biomarkers of Brain Atrophy in Huntington’s Disease (restricted access) (61 views) | | Effects of a novel Nodal-targeting monoclonal antibody in melanoma (restricted access) (52 views) | | Elucidating the role of the pLG72 R30K substitution in schizophreniasusceptibility (public domain) (1 views) | | Evaluation of cerebral hemodynamics with microbubble enhanced ultrasound imaging and magnetic resonance imaging in MS patients (public domain) (22 views) | | Evidence for a direct association between cortical atrophy and cognitive impairment in relapsing–remitting MS (restricted access) (56 views) | | Evidence for Microvascular Dysfunction in Hypertrophic Cardiomyopathy New Insights From Multiparametric Magnetic Resonance Imaging (public domain) (46 views) | | FK506 binding protein 51 positively regulates melanoma stemness and metastatic potential (public domain) (57 views) | | Fluoxetine Prevents Ab1-42-Induced Toxicity via a Paracrine Signaling Mediated by Transforming-Growth- Factor-b1 (public domain) (29 views) | | Frequency Encoding for Simultaneous Display of Multimodality Images (public domain) (34 views) | | Functional analyses yield detailedinsight into the mechanism of thrombin inhibition by the antihemostatic salivary protein cE5 from Anopheles gambiae (public domain) (1 views) | | Functional Characterization of Brain Tumors: An Overview of the Potential Clinical Value (restricted access) (65 views) | | Generalized formalism of the Extended Phase Diagram and computational applications including an MRI simulator (restricted access) (66 views) | | Grey matter loss in relapsing–remitting multiple sclerosis: A voxel-based morphometry study (restricted access) (69 views) | | Head and Neck Veins of the Mouse. A Magnetic Resonance, Micro Computed Tomography and High Frequency Color Doppler Ultrasound Study (public domain) (73 views) | | Hydroxylamine-O-sulfonamide is a versatile lead compound for the development of carbonic anhydrase inhibitors (restricted access) (71 views) | | Imaging of brain perfusion in multiple sclerosis and neurodegenerative diseases: association with endothelial factors. An interim analysis (public domain) (60 views) | | Imaging of brain TSPO expression in a mouse model of amyotrophic lateral sclerosis with 18F-DPA-714 and micro-PET/CT (restricted access) (91 views) | | In vivo imaging and characterization of [(18)F]DPA-714, a potential new TSPO ligand, in mouse brain and peripheral tissues using small-animal PET (restricted access) (68 views) | | Inhibition of Aβ Amyloid Growth and Toxicity by Silybins: The Crucial Role of Stereochemistry (public domain) (1 views) | | Inorganic Stressors of Ubiquitin (restricted access) (25 views) | | Insights into the anticancer properties of the first antimicrobialpeptide from Archaea (public domain) (1 views) | | Integrated Software for the Analysis of Brain PET/SPECT Studies with Partial-Volume-Effect Correction (public domain) (65 views) | | Internal Jugular Vein Blood Flow in Multiple Sclerosis Patients and Matched Controls (public domain) (56 views) | | Laparoscopic transposition of lower pole crossing vessels (vascular hitch) in children with pelviureteric junction obstruction (public domain) (21 views) | | Liver and Spleen Volumetry with Quantitative MR Imaging and Dual-Space Clustering Segmentation (public domain) (43 views) | | Long period fiber grating nano-optrode for cancer biomarker detection. (public domain) (52 views) | | Low power charge division circuits for wireless applications based on silicon photomultipliers (restricted access) (53 views) | | Magnetic resonance imaging in the assessment of patients with heart failure (restricted access) (89 views) | | Method of generating 2D or 3D maps of MRI T1 and T2 relaxation times (public domain) (48 views) | | Modeling Tracer Kinetics in Dynamic GdlDTPA MR Imaging (public domain) (40 views) | | Molecular Imaging of Vulnerable Atherosclerotic Plaques in Animal Models (public domain) (23 views) | | Monoclonal antibodies against pools of mono- and polyacetylated peptides selectively recognize acetylated lysines within the context of the original antigen (restricted access) (33 views) | | MRI-based volumetry of head compartments: Normative values of healthy adults (restricted access) (43 views) | | Multiparametric display of spin-echo data from MR studies of brain. (restricted access) (236 views) | | New Anti-Nodal Monoclonal Antibodies Targeting the Nodal Pre-Helix Loop Involved in Cripto-1 Binding (public domain) (69 views) | | Noninvasive molecular imaging of neuroinflammation (public domain) (7 views) | | Novel Approach for Evaluation of Bacteroides fragilis Protective Role against Bartonella henselae Liver Damage in Immunocompromised Murine Model (public domain) (1 views) | | Out of the active site binding pocket for carbonic anhydrase inhibitors (restricted access) (66 views) | | Pegylated Trastuzumab Fragments Acquire an Increased in Vivo Stability but Show a Largely Reduced Affinity for the Target Antigen (public domain) (89 views) | | Proteins involved in sleep homeostasis: Biophysical characterization of INC and its partners (public domain) (24 views) | | Quantitative multi-parameter mapping of R1, PD, MT, and R2∗ at 3T: a multi-center validation (restricted access) (67 views) | | Regional changes in type 1 cannabinoid receptor availability in Parkinson’s disease in vivo (public domain) (46 views) | | Regulating levels of the neuromodulator D-serine in human brain: structural insight into pLG72 and D-amino acid oxidase interaction (public domain) (39 views) | | Role of risk stratification by SPECT, PET and hybrid imaging in guiding management of stable patients with ischaemic heart disease: expert pane of the EANM cardiovascular committee and EACVI (restricted access) (79 views) | | SCUOLA POLITECNICA E DELLE SCIENZE DI BASE DIPARTIMENTO DI INGEGNERIA ELETTRICA E TECNOLOGIE DELL’INFORMAZIONE D.I.E.T.I TESI DI LAUREA IN INGEGNERIA BIOMEDICA (public domain) (47 views) | | Simultaneous Display of Multiple MR Parameters with "Quantitative Magnetic Color Imaging" (restricted access) (245 views) | | Small Animal PET: A Review of Commercially Available Imaging Systems (restricted access) (51 views) | | Stereotaxy-Based Regional Brain Volumetry Applied to Segmented MRI: Validation and Results in Deficit and Nondeficit Schizophrenia (public domain) (52 views) | | Thermus thermophilus as source of thermozymes for biotechnologicalapplications: homologous expression and biochemical characterization of anα-galactosidase. (public domain) (1 views) | | To evaluate the usefulness and the applicability to the study of joint knee cartilage of T2 and T2ρ maps obtained with a new sequence protocol on a dedicated open MRI system (public domain) (55 views) | | Ubiquitin Associates with the N-Terminal Domain of Nerve Growth Factor: The Role of Copper(II) Ions (restricted access) (6 views) | | Unified segmentation based correction of R1 brain maps for RF transmit field inhomogeneities (UNICORT) (restricted access) (55 views) | | Unsupervised, Automated Segmentation of the Normal Brain Using a Multispectral Relaxometric Magnetic Resonance Approach (restricted access) (250 views) | | Vascular Disease in Multiple Sclerosis: A Real Thing? (public domain) (31 views) | | Vascular Disease in Patients with Multiple Sclerosis: A Review (public domain) (33 views) | | Voxel-based comparison of rCBF SPET images in frontotemporal dementia and Alzheimer’s disease highlights the involvement of different cortical networks (restricted access) (67 views) | | Whole-brain atrophy in multiple sclerosis measured by two segmentation processes from various MRI sequences (restricted access) (59 views) |
Related bibliography▼[Search related bibliography on PubMed]
<=2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 ALL YEARS
Sort by: date ▼▲ title ▲ ▼ journal ▲ ▼ authors ▲ ▼ impact factor ▲ ▼* Combined microcomputed tomography, biomechanical and histomorphometric analysis of the peri-implant bone: a pilot study in minipig model (30 views)Gramanzini M, Gargiulo S, Zarone F, Megna R, Apicella A, Aversa R, Salvatore M, Mancini M, Sorrentino R, Brunetti A
Dent Mater (ISSN: 1879-0097electronic, 0109-5641linking), 2016 Jun; 32(6): 794-806.
View Export to BibTeX Export to EndNote Upload PDF
1 Records ( 1 excluding Abstracts and Conferences). Total impact factor: 3.769 ( 3.769 excluding Abstracts and Conferences). Total 5-year impact factor: 4.433 ( 4.433 excluding Abstracts and Conferences).
Your bibliography query: ([btitle, keywords, abstract] MICRO AND [btitle, keywords, abstract] MINIPIG AND [btitle, keywords, abstract] MODEL)
|
|
Last modified by Marco Comerci on Tuesday 19 April 2016, 12:00:15 369 views. Last viewed on Wednesday 12 July 2017, 3:44:21
|
Facilities
Available positions
Meetings
Other resources
|
INCIPIT
ISTAPCA
Euro-BioImaging
Instruct-IT
Fondazione Veronesi
Fondo Europeo Pesca
INMiND
PRIN
eHealthNet
Ponrec
MFAG Grant
Sperimentato su pazienti pediatrici un esoscheletro personalizzato progettato da ricercatori Cnr