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 | | Name | Daniela Marasco | | Area | Research and Development | | Position | Associated Scientist | | Work site | Naples - Mezzocannone | | Address | Via Mezzocannone 16, 80134 Naples - Italy | | E-mail | daniela.marasco unina.it | | Office phone | +39 081-2534512 |
| Curriculum ▼
Daniela Marasco graduated
in chemistry in 1998, at the University of Naples Federico II in Bioinorganic
Chemistry and in 2002 she attained Doctorate in Chemical Sciences. From 2002
to 2009 she worked at the Insitute of Biostructures and Bioimaging (IBB) of the
Italian Research National Council as post-doc. From 2009 she is Reseacher of General
Chemistry. She is teacher of “General
Chemistry” and Techniques of Structural Biology” at University of Naples
"Federico II".
The research activities of
Daniela Marasco are focused on the relationships between structure and activities
of biological macromolecules. Primarily the chemical synthesis of proteins,
peptides and peptidomimetics, single and as libraries. The identifications of
peptide-based molecules as modulators of protein-protein interactions. These research
topics are carried out by combining chemical synthetic routes,
mass-spectrometry, spectroscopic techniques (circular dicroism, Fluorescence)
and biochemical binding assays as ELISA, SPR, ITC, FRET.
Dr. Marasco is co-author of
about 65 publications on international journals (among which JACS, PNAS, NAR, Stem Cells), book chapters,
and four patents.
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Bibliography ▼
<=2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 ALL YEARS
Sort by: date ▼▲ title ▲ ▼ journal ▲ ▼ authors ▲ ▼ impact factor ▲ ▼* Structural investigation of a C-terminal EphA2 receptor mutant: Does mutation affect the structure and interaction properties of the Sam domain? (1 views)Mercurio FA, Costantini S, Di Natale C, Pirone L, Guariniello S, Scognamiglio PL, Marasco D, Pedone EM, Leone M Biochim Biophys Acta (ISSN: 0006-3002print, 0006-3002linking), 2017 Jun 06; 1865(9): 1095-1104.
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* Characterization of linear mimetic peptides of Interleukin-22 from dissection of protein interfaces (5 views)La Manna S, Scognamiglio PL, Di Natale C, Leone M, Mercurio FA, Malfitano AM, Cianfarani F, Madonna S, Caravella S, Albanesi C, Novellino E, Marasco D Biochimie (ISSN: 1638-6183electronic, 0300-9084linking), 2017 May 04; N/D: N/D-N/D.
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* Unique Footprint in the scl1. 3 Locus Affects Adhesion and Biofilm Formation of the Invasive M3-Type Group A Streptococcus (21 views)Bachert BA, Choi SJ, Lasala PR, Harper TI, Mcnitt DH, Boehm DT, Caswell CC, Ciborowski P, Keene DR, Flores AR, Musser JM, Squeglia F, Marasco D, Berisio R, Lukomski S Front Cell Infect Microbiol (ISSN: 2235-2988electronic, 2235-2988linking), 2016 Aug 31; 6: 90-90.
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* Destabilisation, aggregation, toxicity and cytosolic mislocalisation of nucleophosmin regions associated with acute myeloid leukemia (18 views)Scognamiglio PL, Di Natale C, Leone M, Cascella R, Cecchi C, Lirussi L, Antoniali G, Riccardi D, Morelli G, Tell G, Chiti F, Marasco D Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2016 Aug 1; N/D: N/D-N/D.
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* Diolein based nanostructures as targeted theranostics (49 views)Accardo A, Arena F, Gianolio E, Marasco D, Ringhieri P, Boffa C, Bardini P, Aime S, Morelli G Journal Of Biomedical Nanotechnology (ISSN: 1550-7033), 2016; 12(5): 1076-1088.
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* Nucleophosmin contains amyloidogenic regions that are able to form toxic aggregates under physiological conditions (47 views)Di Natale C, Scognamiglio PL, Cascella R, Cecchi C, Russo A, Leone M, Penco A, Relini A, Federici L, Di Matteo A, Chiti F, Vitagliano L, Marasco D The Faseb Journal (ISSN: 1530-6860, 1530-6860electronic), 2015 Sep; 29(9): 3689-3701.
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* Osteogenic properties of a short BMP-2 chimera peptide (45 views)Falcigno L, D'Auria G, Calvanese L, Marasco D, Iacobelli R, Scognamiglio PL, Brun P, Danesin R, Pasqualin M, Castagliuolo I, Dettin M J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2015; 21(9): 700-709.
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* Peptide Fragments of Odin-Sam1: Conformational Analysis and Interaction Studies with EphA2-Sam (60 views)Mercurio FA, Di Natale C, Pirone L, Scognamiglio PL, Marasco D, Pedone EM, Saviano M, Leone M Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2015; 16(11): 1629-1636.
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* Cd And Nmr Conformational Studies Of A Peptide Encompassing The Mid Loop Interface Of Ship2-Sam (46 views)Mercurio FA, Scognamiglio PL, Di Natale C, Marasco D, Pellecchia M, Leone M Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2014 Nov; 101(11): 1088-1098.
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* Lead Optimization of P5U and Urantide: Discovery of Novel Potent Ligands at the Urotensin-II Receptor (86 views)Carotenuto A, Auriemma L, Merlino F, Yousif AM, Marasco D, Limatola A, Campiglia P, Gomez-Monterrey I, Santicioli P, Meini S, Maggi CA, Novellino E, Grieco P J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2014 Jul 24; 57(14): 5965-5974.
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* Structural and binding properties of the PASTA domain of PonA2, a key penicillin binding protein from Mycobacterium tuberculosis (62 views)Calvanese L, Falcigno L, Maglione C, Marasco D, Ruggiero A, Squeglia F, Berisio R, D'Auria G Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2014 Jul; 101(7): 712-719.
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* G-quadruplex DNA recognition by nucleophosmin: new insights from protein dissection (66 views)Scognamiglio PL, Di Natale C, Leone M, Poletto M, Vitagliano L, Tell G, Marasco D Biochim Biophys Acta (ISSN: 0006-3002print, 0006-3002linking, 0005-2728), 2014 Jun; 1840(6): 2050-2059.
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* SIRT1 gene expression upon genotoxic damage is regulated by APE1 through nCaRE-promoter elements (89 views)Antoniali G, Lirussi L, D'Ambrosio C, Dal Piaz F, Vascotto C, Casarano E, Marasco D, Scaloni A, Fogolari F, Tell G Molecular Biology Of The Cell (ISSN: 1059-1524), 2014 Feb 15; 25(4): 532-547.
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* IL-32 Promotes Angiogenesis (136 views)Nold-Petry CA, Rudloff I, Baumer Y, Ruvo M, Marasco D, Botti P, Farkas L, Cho SX, Zepp JA, Azam T, Dinkel H, Palmer BE, Boisvert WA, Cool CD, Taraseviciene-Stewart L, Heinhuis B, Joosten LA, Dinarello CA, Voelkel NF, Nold MF Journal Of Immunology (ISSN: 0022-1767), 2014 Jan 15; 192(2): 589-602.
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* Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells (49 views)Lirussi L, Antoniali G, Vascotto C, D'Ambrosio C, Poletto M, Romanello M, Marasco D, Leone M, Quadrifoglio F, Bhakat KK, Scaloni A, Tell G Molecular Biology Of The Cell (ISSN: 1059-1524), 2012 Oct 15; 23(20): 4079-4096.
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* HIV p24 as Scaffold for Presenting Conformational HIV Env Antigens (83 views)Tagliamonte M, Marasco D, Ruggiero A, de Stradis A, Tornesello ML, Totrov M, Buonaguro FM, Buonaguro L Plos One (ISSN: 1932-6203, 1932-6203electronic), 2012 Sep 17; 7(8): N/D-N/D.
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* Acetylation on critical lysine residues of Apurinic/apyrimidinic endonuclease 1 (APE1) in triple negative breast cancers (57 views)Poletto M, Di Loreto C, Marasco D, Poletto E, Puglisi F, Damante G, Tell G Biochemical And Biophysical Research Communications (ISSN: 0006-291x), 2012 Jul 20; 424(1): 34-39.
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* Solution Structure of the First Sam Domain of Odin and Binding Studies with the EphA2 Receptor (44 views)Mercurio FA, Marasco D, Pirone L, Pedone E, Pellecchia M, Leone M Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2012 Mar 13; 51(10): 2136-2145.
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* Chemical basis of peptidoglycan discrimination by PrkC, a key kinase involved in bacterial resuscitation from dormancy (39 views)Squeglia F, Marchetti R, Ruggiero A, Lanzetta R, Marasco D, Dworkin J, Petoukhov M, Molinaro A, Berisio R, Silipo A J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2011 Dec 28; 133(51): 20676-20679.
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* GSM48878: CD8 IL2-D2 (40 views)Viparelli F, Doti N, Sandomenico A, Marasco D, Dathan NA, Miele C, Beguinot F, Monti SM, Ruvo M Gene Expression Omnibus, 2011 Dec 2; 59(2): 302-308.
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* Structural and functional insights into IkappaB-alpha/HIV-1 Tat interaction (56 views)Vitagliano L, Fiume G, Scognamiglio PL, Doti N, Cannavo R, Puca A, Pedone C, Scala G, Quinto I, Marasco D Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2011 Sep; 93(9): 1592-1600.
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* Critical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functions (53 views)Fantini D, Vascotto C, Marasco D, D'Ambrosio C, Romanello M, Vitagliano L, Pedone C, Poletto M, Cesaratto L, Quadrifoglio F, Scaloni A, Radicella JP, Tell G Nucleic Acids Res (ISSN: 1362-4962, 0305-1048, 1362-4962electronic), 2010 Dec; 38(22): 8239-8256.
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* Structural Investigations on the Nodal-Cripto Binding: A Theoretical and Experimental Approach (51 views)Calvanese L, Marasco D, Doti N, Saporito A, D'Auria G, Paolillo L, Ruvo M, Falcigno L Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2010 Nov; 93(11): 1011-1021.
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* Residues 762-801 of PLD1 mediate the interaction with PED/PEA15 (44 views)Doti N, Cassese A, Marasco D, Paturzo F, Sabatella M, Viparelli F, Dathan N, Monti SM, Miele C, Formisano P, Beguinot F, Ruvo M Mol Biosyst (ISSN: 1742-206x), 2010 Oct; 6(10): 2039-2048.
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* A Small Synthetic Cripto Blocking Peptide Improves Neural Induction, Dopaminergic Differentiation, and Functional Integration of Mouse Embryonic Stem Cells in a Rat Model of Parkinson's Disease (58 views)Lonardo E, Parish CL, Ponticelli S, Marasco D, Ribeiro D, Ruvo M, De Falco S, Arenas E, Minchiotti G Stem Cells (ISSN: 1066-5099), 2010 Sep; 28(8): 1326-1337.
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* Selective Disruption of Insulin-like Growth Factor-1 (IGF-1) Signaling via Phosphoinositide-dependent Kinase-1 Prevents the Protective Effect of IGF-1 on Human Cancer Cell Death (54 views)Alberobello AT, D'Esposito V, Marasco D, Doti N, Ruvo M, Bianco R, Tortora G, Esposito I, Fiory F, Miele C, Beguinot F, Formisano P J Biol Chem Journal Of Biological Chemistry (ISSN: 0021-9258, 1083-351x), 2010 Feb 26; 285(9): 6563-6572.
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* Cell recruitment and transfection in gene activated collagen matrix (56 views)Orsi S, De Capua A, Guarnieri D, Marasco D, Netti PA Biomaterials (ISSN: 0142-9612, 1878-5905electronic, 0142-9612linking), 2010 Jan; 31(3): 570-576.
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* Expression, purification, crystallization and preliminary X-ray crystallographic analysis of the resuscitation promoting factor interacting protein RipA from M. tuberculosis (41 views)Ruggiero A, Squeglia F, Esposito C, Marasco D, Pedone E, Pedone C, Berisio R Protein And Peptide Letters (ISSN: 0929-8665, 1875-5305), 2010 Jan; 17(1): 70-73.
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* The role of the glycan moiety on the structure-function relationships of PD-L1, type 1 ribosome-inactivating protein from P. dioica leaves (35 views)Severino V, Chambery A, Di Maro A, Marasco D, Ruggiero A, Berisio R, Giansanti F, Ippoliti R, Parente A Mol Biosyst (ISSN: 1742-206x), 2010; 6(3): 570-579.
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* The dimeric structure of Sulfolobus solfataricus thioredoxin A2 and the basis of its thermostability (44 views)Ruggiero A, Masullo M, Marasco D, Ruocco MR, Grimaldi P, Arcari P, Zagari A, Vitagliano L Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2009 Dec; 77(4): 1004-1008.
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* Generation And Functional Characterization Of A Bcl10-Inhibitory Peptide That Represses Nf-Kappa B Activation (50 views)Marasco D, Stilo R, Sandomenico A, Monti SM, Tizzano B, De Capua A, Varricchio E, Liguoro D, Zotti T, Formisano S, Ruvo M, Vito P Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2009 Sep 15; 422(3): 553-561.
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* Crystallization and preliminary X-ray crystallographic analysis of two dimeric hyperthermostable thioredoxins isolated from Sulfolobus solfataricus (38 views)Ruggiero A, Lanzotti MA, Ruocco MR, Grimaldi P, Marasco D, Arcari P, Masullo M, Zagari A, Vitagliano L Communicationsacta Crystallographica Section F Structural Biology And Crystallization (ISSN: 1744-3091, 1744-4309), 2009 Jun; 65: 604-607.
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* Protein-protein interactions: a simple strategy to identify binding sites and peptide antagonists (56 views)Sandomenico A, Monti SM, Sabatella M, De Capua A, Tornatore L, Doti N, Viparelli F, Dathan NA, Pedone C, Ruvo M, Marasco D Chem Biol Drug Des Chemical Biology And Drug Design (ISSN: 1747-0285, 1747-0277), 2009 May; 73(5): 483-493.
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* Structural insights into the interaction between the Cripto CFC domain and the ALK4 receptor (50 views)Calvanese L, Saporito A, Oliva R, D'Auria G, Pedone C, Paolillo L, Ruvo M, Marasco D, Falcigno L J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 175-183.
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* Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity (67 views)Ciaccio C, Tundo GR, Grasso G, Spoto G, Marasco D, Ruvo M, Gioia M, Rizzarelli E, Coletta M J Mol Biol Journal Of Molecular Biology (ISSN: 1089-8638, 0022-2836, 1089-8638electronic), 2009 Feb 6; 385(5): 1556-1567.
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* Gadd45beta dimerization does not affect MKK7 binding (41 views)Tornatore L, Montil SM, Marasco D, Dathan N, Vitale RM, Benedetti E, Pedone C, Papa S, Franzoso G, Ruvo M Adv Exp Med Biol (ISSN: 0065-2598, 0065-2598print), 2009; 611: 367-368.
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* Peptide antagonists of the PED-hPLD1 binding (38 views)Viparelli F, Doti N, Monti SM, Marasco D, Dathan N, Pedone C, Miele C, Formisano P, Beguinot F, Ruvo M Adv Exp Med Biol (ISSN: 0065-2598, 0065-2598print, 0065-2598linking), 2009; 611: 445-446.
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* Self-association regions in the CARD of Bcl-10 (35 views)Ruvo M, Sandomenico A, Marasco D, Monti SM, Tizzano B, De Capua A, Pedone C, Saporito A, Vitale RM, Formisano S, Stilo R, Liguoro D Adv Exp Med Biol (ISSN: 0065-2598, 0065-2598print), 2009; 611: 569-570.
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* Modulation of Angiogenesis by a Tetrameric Tripeptide That Antagonizes Vascular Endothelial Growth Factor Receptor (53 views)Ponticelli S, Marasco D, Tarallo V, Albuquerque RJC, Mitola S, Takeda A, Stassen J, Presta M, Ambati J, Ruvo M, De Falco S J Biol Chem Journal Of Biological Chemistry (ISSN: 0021-9258, 1083-351x), 2008 Dec 5; 283(49): 34250-34259.
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* Targeting of PED/PEA-15 molecular interaction with phospholipase D1 enhances insulin sensitivity in skeletal muscle cells (51 views)Viparelli F, Cassese A, Doti N, Paturzo F, Marasco D, Dathan NA, Monti SM, Basile G, Ungaro P, Sabatella M, Miele C, Teperino R, Consiglio E, Pedone C, Beguinot F, Formisano P, Ruvo M J Biol Chem Journal Of Biological Chemistry (ISSN: 0021-9258, 1083-351x), 2008 Sep 1; 283(31): 21769-21778.
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* An analysis of deletion mutants of the PLD1 D4 domain defines short regions within the PLD1 interacting with PED/PEA15: implications for the development of peptides-specific antagonist (42 views)Doti N, Marasco D, Sabatella M, Monti SM, Dathan N, Viparelli F, Cassese A, Miele C, Pedone C, Ruvo M J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
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* Angiogenesis modulation: identification of tetrameric tripeptide as inhibitor of VEGFR-1 by the screening of peptide combinatiorial libraries (41 views)Ponticelli S, Takeda A, Mitola S, Stassen J, Presta M, Ambati J, Ruvo M, De Falco S, Marasco D J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
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* Peptide antagonists of protein-protein interactions identified by screening protein fragments derived by enzyme degradation (32 views)Ruvo M, Marasco D, Viparelli F, Tornatore L, Sandomenico A, Doti N, Pedone C, Benedetti E, Monti SM J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
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* Abeta(25-35) And Its C- And/Or N-Blocked Derivatives: Copper Driven Structural Features And Neurotoxicity (62 views)Giuffrida ML, Grasso G, Ruvo M, Pedone C, Saporito A, Marasco D, Pignataro B, Cascio C, Copani A, Rizzarelli E Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Feb 15; 85(3): 623-633.
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* Does Tetracycline Bind Helix 2 Of Prion? An Integrated Spectroscopical And Computational Study Of The Interaction Between The Antibiotic And Alpha Helix 2 Human Prion Protein Fragments (75 views)Ronga L, Langella E, Palladino P, Marasco D, Tizzano B, Saviano M, Pedone C, Improta R, Ruvo M Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2007 Feb 15; 66(3): 707-715.
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* Solution structure of mouse Cripto CFC domain and its inactive variant Trp107Ala (45 views)Calvanese L, Saporito A, Marasco D, D'Auria G, Minchiotti G, Pedone C, Paolillo L, Falcigno L, Ruvo M J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Nov 30; 49(24): 7054-7062.
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* Chemical synthesis of mouse Cripto CFC variants (46 views)Marasco D, Saporito A, Ponticelli S, Chambery A, De Falco S, Pedone C, Minchiotti G, Ruvo M Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Sep 15; 64(3): 779-788.
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* A new ligand for immunoglobulin G subdomains by screening of a synthetic peptide library (51 views)Verdoliva A, Marasco D, De Capua A, Saporito A, Bellofiore P, Manfredi V, Fattorusso R, Pedone C, Ruvo M Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2005 Jul; 6(7): 1242-1253.
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* The Human Prion Protein Alpha2 Helix: A Thermodynamic Study Of Its Conformational Preferences (38 views)Tizzano B, Palladino P, De Capua A, Marasco D, Rossi F, Benedetti E, Pedone C, Ragone R, Ruvo M Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2005 Apr 1; 59(1): 72-79.
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* Chemical synthesis of the of Gstl protein by an NCL method on a X-Met site (44 views)Marasco D, Saporito A, Patriarca E, Fasulo R, Spasiano A, Pedone C, Benedetti E, Ruvo M Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2005; 80(4): N/D-N/D.
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* Erratum: A new ligand for immunoglobulin G subdomains by screening of a synthetic peptide library (ChemBioChem (2005) 6 (1242-1253)) (34 views)Verdoliva A, Marasco D, De Capua A, Saporito A, Bellofiore P, Manfredi V, Fattorusso R, Pedone C, Ruvo M Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2005; 20(4): 1307-1307.
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* Conformational conversion of prion proteins: Role synthetic PRP 173-195 fibrillogenic peptide (37 views)Tizzano B, Marasco D, Benedetti E, De Capua A, Palladino P, Pedone C, Perretta G, Rossi F, Ragone R, Ruvo M Peptide Revolution, 2004; N/D: N/D-N/D.
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* Design of a new mimochrome with unique topology (46 views)Lombardi A, Nastri F, Marasco D, Maglio O, De Sanctis G, Sinibaldi F, Santucci R, Coletta M, Pavone V Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2003 Nov 21; 9(22): 5643-5654.
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Miniaturized metalloproteins: Application to iron-sulfur proteins (252 views)Lombardi A, Marasco D, Maglio O, Di Costanzo L, Nasti F, Pavone V Proc Natl Acad Sci U S A (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2000 Oct 24; 97(22): 11922-11927.
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Evolutionary Screening And Adsorption Behavior Of Engineered M13 Bacteriophage And Derived Dodecapeptide For Selective Decoration Of Gold Interfaces (47 views)Causa F, Della Moglie R, Iaccino E, Mimmi S, Marasco D, Scognamiglio PL, Battista E, Palmieri C, Cosenza C, Sanguigno L, Quinto I, Scala G, Netti PA Journal Of Colloid And Interface Science (ISSN: 0021-9797, 1095-7103electronic, 0021-9797linking), N/D; 389(1): 220-229.
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Gadd45 Beta Forms A Homodimeric Complex That Binds Tightly To Mkk7 (63 views)Tornatore L, Marasco D, Dathan N, Vitale RM, Benedetti E, Papa S, Franzoso G, Ruvo M, Monti SM J Mol Biol Journal Of Molecular Biology (ISSN: 0022-2836, 0022-2283, 1089-8638), N/D; 378(1): 111-111.
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84 Records ( 74 excluding Abstracts and Conferences). Total impact factor: 304.444 ( 280.905 excluding Abstracts and Conferences). Total 5-year impact factor: 313.991 ( 289.19 excluding Abstracts and Conferences).
Your bibliography query: [author] MARASCO_D
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