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 | | Name | Danilo Milardi | | Area | Research and Development | | Position | Researcher | | Work site | Catania | | Address | c/o Dipartimento di Scienze Chimiche Viale Andrea Doria 6, 95125 Catania - Italy | | E-mail | dmilardi unict.it | | Office phone | +39 095-7338438 |
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Curriculum ▼
Danilo Milardi, was born in Catania on July 22,
1968, and graduated in Industrial Chemistry at the University of Catania on
July 16, 1992 with vote 110/110 and with honours. He obtained a PhD in Physical
Chemistry on October 30, 1996. In 1997 he obtained a fellowship granted by the
University of Catania. In 1999 he obtained a post-doc position at the
University of Catania. Since December 2001 he is research scientist at the
Italian Consiglio Nazionale delle Ricerche (CNR) Instituto di Biostrutture e
Bioimmagini. During the academic years 2001-2002, 2002-2003, 2007-2008 and
2008-2009 he was lecturer of Physical-Chemistry and General-Inorganic Chemistry
at the University of Catania. He is member of the advisory committee of the Institute
of Biostrucyure and Bioimaging. He is the scientific responsible of many
projects either from CNR (RSTL 620) or Ministery of University (public-private
Lab CNR-Wyeth Lederle n DM20919, PRIN 2015. He co-edited with E. Rizzarelli the
book entitled Neurodegeneration: Metallostasis and Proteostasis, 2011, Royal
Society of Chemistry UK. He is editor of the Special Issue - Molecular
Dynamics: New Advances in Drug Discovery", European Journal of Medicinal
Chemistry, Elsevier, 2014. Dr. Milardi is using various experimental and
theoretical methods to study protein stability, and to characterize how
environmental factors (e. g. lipid membranes and metal ions) may promote
protein misfolding/aggregation. More recently, he has focused on the role
played by environmental factors in causing the derangement of the Ubiquitin
Proteasome System. He is author of more than 70 papers published on
peer-reviewed journals.
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Bibliography ▼
<=2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 ALL YEARS
Sort by: date ▼▲ title ▲ ▼ journal ▲ ▼ authors ▲ ▼ impact factor ▲ ▼* Stabilization vs. destabilization of G-quadruplex superstructures: the role of the porphyrin derivative having spermine arms (1 views)D'Urso A, Randazzo R, Rizzo V, Gangemi CMA, Romanucci V, Zarrelli A, Tomaselli G, Milardi D, Borbone N, Purrello R, Piccialli G, Di Fabio G, Oliviero G Phys Chem Chem Phys (ISSN: 1463-9084electronic, 1463-9076linking), 2017 Jul 14; 19(26): 17404-17410.
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* New comprehensive studies of a gold(III) Dithiocarbamate complex with proven anticancer properties: Aqueous dissolution with cyclodextrins, pharmacokinetics and upstream inhibition of the ubiquitin-proteasome pathway (1 views)Tomasello MF, Nardon C, Lanza V, Di Natale G, Pettenuzzo N, Salmaso S, Milardi D, Caliceti P, Pappalardo G, Fregona D Eur J Med Chem (ISSN: 1768-3254electronic, 0223-5234linking), 2017 Jun 19; 138: 115-127.
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* Inhibition of Abeta Amyloid Growth and Toxicity by Silybins: The Crucial Role of Stereochemistry (1 views) (PDF 1 views)Sciacca MFM, Romanucci V, Zarrelli A, Monaco I, Lolicato F, Spinella N, Galati C, Grasso G, D'Urso L, Romeo M, Diomede L, Salmona M, Bongiorno C, Di Fabio G, La Rosa C, Milardi D Acs Chem Neurosci (ISSN: 1948-7193electronic, 1948-7193linking), 2017 Jun 09; N/D: N/D-N/D.
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* Multiple functions of insulin-degrading enzyme: a metabolic crosslight? (1 views)Tundo GR, Sbardella D, Ciaccio C, Grasso G, Gioia M, Coletta A, Polticelli F, Di Pierro D, Milardi D, Van Endert P, Marini S, Coletta M Crit Rev Biochem Mol Biol (ISSN: 1549-7798electronic, 1040-9238linking), 2017 Jun; N/D: 1-29.
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* The double faced role of copper in Ab homeostasis: A survey on the interrelationship between metal dyshomeostasis, UPS functioning and autophagy in neurodegeneration (4 views)Grasso G, Santoro AM, Lanza V, Sbardella D, Tundo GR, Ciaccio C, Marini S, Coletta M, Milardi D Coordination Chemistry Reviews, 2017 Jun; N/D: 1-22.
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* Extracellular truncated tau causes early presynaptic dysfunction associated with Alzheimer's disease and other tauopathies (1 views)Florenzano F, Veronica C, Ciasca G, Ciotti MT, Pittaluga A, Olivero G, Feligioni M, Iannuzzi F, Latina V, Sciacca MFM, Sinopoli A, Milardi D, Pappalardo G, De Spirito M, Papi M, Atlante A, Bobba A, Borreca A, Calissano P, Amadoro G Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2017 Apr 22; N/D: N/D-N/D.
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* Extracellular truncated tau causes early presynaptic dysfunction associated with Alzheimer's disease and other tauopathies (4 views)Florenzano F, Veronica C, Ciasca G, Ciotti MT, Pittaluga A, Olivero G, Feligioni M, Iannuzzi F, Latina V, Sciacca MFM, Sinopoli A, Milardi D, Pappalardo G, De Spirito M, Papi M, Atlante A, Bobba A, Borreca A, Calissano P, Amadoro G Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2017 Apr 22; N/D: N/D-N/D.
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* Ubiquitin Associates with the N-Terminal Domain of Nerve Growth Factor: The Role of Copper(II) Ions (7 views) (PDF 6 views)Lanza V, Travaglia A, Malgieri G, Fattorusso R, GrassoG, Di Natale G, Zito V, Arena G, Milardi D, Rizzarelli E Chemistry (ISSN: 1521-3765electronic, 0947-6539linking), 2016 Dec 05; 22(49): 17767-17775.
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* Copper(II) ions affect the gating dynamics of the 20S proteasome: a molecular and in cell study (24 views)Santoro AM, Monaco I, Attanasio F, Lanza V, Pappalardo G, Tomasello MF, Cunsolo A, Rizzarelli E, De Luigi A, Salmona M, Milardi D Sci Rep (ISSN: 2045-2322electronic, 2045-2322linking), 2016 Sep 16; 6: 33444-33444.
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* Cationic porphyrins are tunable gatekeepers of the 20S proteasome (377 views) (PDF 70 views)Santoro AM, Cunsolo A, D'Urso A, Sbardella D, Tundo GR, Ciaccio C, Coletta M, Diana D, Fattorusso R, Persico M, Di Dato A, Fattorusso C, Milardi D, Purrello R Chemical Science (ISSN: 2041-6539, 2041-6520), 2016; 7(2): 1286-1297.
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* Long range Trp-Trp interaction initiates the folding pathway of a pro-angiogenic beta-hairpin peptide (6 views)Diana D, De Rosa L, Palmieri M, Russomanno A, Russo L, La Rosa C, Milardi D, Colombo G, D'Andrea LD, Fattorusso R Sci Rep (ISSN: 2045-2322electronic, 2045-2322linking), 2015 Nov 25; 5: 16651-16651.
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* Sequential Application of Ligand and Structure Based Modeling Approaches to Index Chemicals for Their hH(4)R Antagonism (56 views)Pappalardo M, Shachaf N, Basile L, Milardi D, Zeidan M, Raiyn J, Guccione S, Rayan A Plos One (ISSN: 1932-6203, 1932-6203electronic), 2014 Oct 16; 9(10): e109340-e109340.
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* The role of copper(II) in the aggregation of human amylin (79 views)Sinopoli A, Magri A, Milardi D, Pappalardo M, Pucci P, Flagiello A, Titman JJ, Nicoletti VG, Caruso G, Pappalardo G, GrassoG Metallomics (ISSN: 1756-591xelectronic, 1756-5901linking), 2014 Oct; 6(10): 1841-1852.
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* Synthesis, biophysical characterization and anti-HIV activity of d(TG(3)AG) Quadruplexes bearing hydrophobic tails at the 5 '-end (80 views)Romanucci V, Milardi D, Campagna T, Gaglione M, Messere A, D'Urso A, Crisafi E, La Rosa C, Zarrelli A, Balzarini J, Di Fabio G Bioorg Med Chem (ISSN: 1464-3391, 0968-0896, 1464-3391electronic), 2014 Feb 1; 22(3): 960-966.
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* Deciphering the zinc coordination properties of the prokaryotic zinc finger domain: The solution structure characterization of Ros87 H42A functional mutant (56 views)Palmieri M, Russo L, Malgieri G, Esposito S, Baglivo I, Rivellino A, Farina B, de Paola I, Zaccaro L, Milardi D, Isernia C, Pedone PV, Fattorusso R J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2014 Feb; 131: 30-36.
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* Zinc To Cadmium Replacement In The Prokaryotic Zinc-Finger Domain (56 views)Malgieri G, Palmieri M, Esposito S, Maione V, Russo L, Baglivo I, De Paola I, Milardi D, Diana D, Zaccaro L, Pedone PV, Fattorusso R, Isernia C Metallomics (ISSN: 1756-591x, 1756-5901, 1756-591xelectronic), 2013 Dec 18; 6(1): 96-104.
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* Inorganic stressors of ubiquitin (43 views) (PDF 25 views)Arena G, Bellia F, Frasca G, Grasso G, Lanza V, Rizzarelli E, Tabbì G, Zito V, Milardi D Inorg Chem (ISSN: 1520-510x, 1520-510xelectronic, 0020-1669linking), 2013 Sep 19; 52(16): 9567-9573.
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* Structural Zn(II) Implies a Switch from Fully Cooperative to Partly Downhill Folding in Highly Homologous Proteins (60 views)Palmieri M, Malgieri G, Russo L, Baglivo I, Esposito S, Netti F, Del Gatto A, De Paola I, Zaccaro L, Pedone PV, Isernia C, Milardi D, Fattorusso R J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2013 Apr 2; 135(13): 5220-5228.
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* Carnosine Inhibits Abeta(42) Aggregation By Perturbing The H-Bond Network In And Around The Central Hydrophobic Cluster (71 views)Attanasio F, Convertino M, Magno A, Caflisch A, Corazza A, Haridas H, Esposito G, Cataldo S, Pignataro B, Milardi D, Rizzarelli E Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2013 Mar 18; 14(5): 583-592.
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* Cations as switches of amyloid-mediated membrane disruption mechanisms: Calcium and IAPP (49 views)Sciacca MFM, Milardi D, Messina GML, Marletta G, Brender JR, Ramamoorthy A, La Rosa C Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2013 Jan 8; 104(1): 173-184.
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* Cationic porphyrins are reversible proteasome inhibitors (86 views)Santoro AM, Lo Giudice MC, D'Urso A, Lauceri R, Purrello R, Milardi D J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2012 Jun 27; 134(25): 10451-10457.
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* Zinc(II) complexes of ubiquitin: speciation, affinity and binding features (56 views)Arena G, Fattorusso R, Grasso G, Grasso GI, Isernia C, Malgieri G, Milardi D, Rizzarelli E Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2011 Oct 4; 17(41): 11596-11603.
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* Membrane interactions and conformational preferences of human and avian prion N-terminal tandem repeats: The role of copper(II) ions, pH, and membrane mimicking environments (70 views)Di Natale G, Pappalardo G, Milardi D, Sciacca MF, Attanasio F, La Mendola D, Rizzarelli E J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2010 Nov 4; 114(43): 13830-13838.
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* Thermodynamics Of Azurin Folding: The Role Of The Copper Ion (26 views)Pappalardo M, Sciacca MFM, Milardi D, Grasso DM, La Rosa C Journal Of Thermal Analysis And Calorimetry (ISSN: 1388-6150), 2008 Sep; 93(2): 575-581.
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* The role played by the α-helix in the unfolding pathway and stability of azurin: Switching between hierarchic and nonhierarchic folding (34 views)Manetto GD, Grasso DM, Milardi D, Pappalardo M, Guzzi R, Sportelli L, Verbeet MP, Canters GW, La Rosa C Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 Nov 5; 8(16): 1941-1949.
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* Determination of the conformation of the human VDAC1 N-terminal peptide, a protein moiety essential for the functional properties of the pore (48 views)De Pinto V, Tomasello F, Messina A, Guarino F, Benz R, La Mendola D, Magrì A, Milardi D, Pappalardo G Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 7; 8(7): 744-756.
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* Environmental factors differently affect human and rat IAPP: Conformational preferences and membrane interactions of IAPP17-29 peptide derivatives (65 views)Pappalardo G, Milardi D, Magrì A, Attanasio F, Impellizzeri G, La Rosa C, Grasso D, Rizzarelli E Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2007; 13(36): 10204-10215.
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* Modelling IAPP's membrane interaction: Conformational preferences and membrane activity of IAPP17-29 peptide derivatives (43 views)Pappalardo G, Milardi D, Magna A, Attanasio F, Impellizzeri G, La Rosa C, Grasso D, Rizzarelli E Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2007; 88(4): N/D-N/D.
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* Role of electrostatics in the thermal stability of ubiquitin: A combined DSC and MM study (25 views)Sciacca MFM, Milardi D, Pappalardo M, La Rosa C, Grasso DM Journal Of Thermal Analysis And Calorimetry (ISSN: 1388-6150), 2006 Nov; 86(2): 311-314.
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* Environmental effects on a prion's helix II domain: copper(II) and membrane interactions with PrP180-193 and its analogues (39 views)Grasso D, Grasso G, Guantieri V, Impellizzeri G, La Rosa C, Milardi D, Micera G, Osz K, Pappalardo G, Rizzarelli E, Sanna D, Sovago I Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2005 Dec 23; 12(2): 537-547.
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* Phase behaviour of polymer-grafted DPPC membranes for drug delivery systems design (30 views)Pappalardo M, Milardi D, Grasso D, La Rosa C Journal Of Thermal Analysis And Calorimetry (ISSN: 1388-6150), 2005 May; 80(2): 413-418.
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* Conformational properties and functional role of the VDAC N-terminal peptide (29 views)De Pinto V, Messina A, Aiello R, Tomasello F, La Mendola D, Magri A, Milardi D, Pappalardo G Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2005; 80(4): N/D-N/D.
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* The effect of copper/zinc replacement on the folding free energy of wild type and Cys3Ala/Cys26Ala azurin (49 views)Guzzi R, Milardi D, La Rosa C, Grasso D, Verbeet MP, Canters GW, Sportelli L International Journal Of Biological Macromolecules (ISSN: 0141-8130), 2003 Jan 15; 31(4-5): 163-170.
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* Metal binding to prion protein (51 views)Bonomo RP, Grasso D, Grasso G, Guantieri V, Impellizzeri G, La Rosa C, Milardi D, Pappalardo G, Tabbì G, Rizzarelli E In Complex Environmentsmetal Ligand Interactions, 2003; 116: 21-39.
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Interactions Of Two O-Phosphorylresveratrol Derivatives With Model Membranes (30 views)Mfm S, Chillemi R, Sciuto S, Pappalardo M, La Rosa C, Grasso D, Milardi D Archives Of Biochemistry And Biophysics (ISSN: 1096-0384, 0003-3986), N/D; 521(1-2): 111-116.
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Metal Binding To Prion Protein, In Metal-Ligand Interactions In Nano-, Micro-, And Macro-Systems In Complex Environments (45 views)Bonomo RP, Grasso D, Grasso G, Guantieri V, Impellizzeri G, La Rosa C, Milardi D, Pappalardo G, Tabbì G, Rizzarelli E In Complex Environmentsmetal Ligand Interactions, N/D; 116: 21-39.
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72 Records ( 64 excluding Abstracts and Conferences). Total impact factor: 288.758 ( 268.792 excluding Abstracts and Conferences). Total 5-year impact factor: 271.279 ( 249.792 excluding Abstracts and Conferences).
Your bibliography query: [author] MILARDI_D
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