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 | | Name | Laura Zaccaro | | Area | Research and Development | | Position | Researcher | | Work site | Naples - Mezzocannone | | Address | Via Mezzocannone 16, 80134 Naples - Italy | | E-mail | lzaccaro unina.it | | Office phone | +39 081 2534566 |
| Research Areas ▼
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Curriculum ▼
Born in Naples on 4th May 1968. 1991: Degree in Pharmacy summa cum laude at University of Naples Federico II (Italy). 1994: Postgraduate specialisation summa cum laude in Pharmaceutical Chemistry at University of Naples Federico II. 1992-1995 CNR Fellowships at the Centre of Biocrystallography, Naples. 1995-1996: Fellowship at Department of Chemistry at University of Naples Federico II. 1996-2000: Research assistent at Biotechnology Faculty of University of Naples Federico II. From 2001 to present day: Researcher at Biostructure and Bioimaging Institute-CNR, Naples. 2001-2002: External Scientist at Department of Organic Chemistry, University of Barcelona-Spain. 2004-2005: contract Professor of General Chemistry at Science Faculty of MM. FF. NN-University of Naples Federico II. 2006-2008: Contract Professor of General Chemistry at Biotechnology Faculty of University of Naples Federico II. The scientific interests of Dr. Zaccaro concern both the development of new molecules with specific activities or able to interact with specific molecular targets, and the structure-activity relationship studies of bioactive systems to understand the molecular device for the biological activity. Dr. Zaccaro has experience in the field of rational design of peptide and peptido-mimetic systems, synthesis in solution and on solid phase, purification by chromatography techniques, structural characterisation by mass spectrometry and spectroscopic techniques and interaction studies by surface plasmon resonance. |
Bibliography ▼
<=2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 ALL YEARS
Sort by: date ▼▲ title ▲ ▼ journal ▲ ▼ authors ▲ ▼ impact factor ▲ ▼* Insights into the anticancer properties of the first antimicrobial peptide from Archaea (1 views)Gaglione R, Pirone L, Farina B, Fusco S, Smaldone G, Aulitto M, Dell'Olmo E, Roscetto E, Del Gatto A, Fattorusso R, Notomista E, Zaccaro L, Arciello A, Pedone E, Contursi P Biochim Biophys Acta (ISSN: 0006-3002print, 0006-3002linking), 2017 Jun 15; 1861(9): 2155-2164.
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* A new cryptic host defense peptide identified in human 11-hydroxysteroid dehydrogenase-1 beta-like: from in silico identification to experimental evidence (14 views)Bosso A, Pirone L, Gaglione R, Pane K, Del Gatto A, Zaccaro L, Di Gaetano S, Diana D, Fattorusso R, Pedone E, Cafaro V, Haagsman HP, Van Dijk A, Scheenstra MR, Zanfardino A, Crescenzi O, Arciello A, Varcamonti M, Veldhuizen EJA, Di Donato A, Notomista E, Pizzo E Biochim Biophys Acta (ISSN: 0006-3002print, 0006-3002linking, 0005-2728), 2017 Apr 25; N/D: N/D-N/D.
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* The (unusual) aspartic acid in the metal coordination sphere of the prokaryotic zinc finger domain (18 views)D'Abrosca G, Russo L, Palmieri M, Baglivo I, Netti F, De Paola I, Zaccaro L, Farina B, Iacovino R, Pedone PV, Isernia C, Fattorusso R, Malgieri G J Chem Res (ISSN: 1873-3344electronic, 0162-0134linking, 0162-0134print), 2016 Aug; 161: 91-98.
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* A Combined NMR and Computational Approach to Determine the RGDechi-hCit-alphav beta3 Integrin Recognition Mode in Isolated Cell Membranes (34 views)Farina B, De Paola I, Russo L, Capasso D, Liguoro A, Gatto AD, Saviano M, Pedone PV, Di Gaetano S, Malgieri G, Zaccaro L, Fattorusso R Chemistry (ISSN: 1521-3765electronic, 0947-6539linking), 2016 Jan 11; 22(2): 681-693.
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* Integrin-targeting with peptide-bioconjugated semiconductor-magnetic nanocrystalline heterostructures (54 views)Valente G, Depalo N, De Paola I, Iacobazzi RM, Denora N, Laquintana V, Comparelli R, Altamura E, Latronico T, Altomare M, Fanizza E, Striccoli M, Agostiano A, Saviano M, Del Gatto A, Zaccaro L, Curri ML Nano Research (ISSN: 1998-0124), 2016; 9(3): 644-662.
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* Cullin3 - BTB interface: A novel target for stapled peptides (74 views)De Paola I, Pirone L, Palmieri M, Balasco N, Esposito L, Russo L, Mazza D, Di Marcotullio L, Di Gaetano S, Malgieri G, Vitagliano L, Pedone E, Zaccaro L Plos One (ISSN: 1932-6203, 1932-6203electronic), 2015 Apr 7; 10(4): e0121149-e0121149.
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* Structural Model of the hUbA1-UbcH10 Quaternary Complex: In Silico and Experimental Analysis of the Protein-Protein Interactions between E1, E2 and Ubiquitin (58 views)Correale S, de Paola I, Morgillo CM, Federico A, Zaccaro L, Pallante P, Galeone A, Fusco A, Pedone E, Luque FJ, Catalanotti B Plos One (ISSN: 1932-6203, 1932-6203electronic), 2014 Nov 6; 9(11): e112082-e112082.
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* Conformational features of human melanin-concentrating hormone: an NMR and computational analysis (43 views)Vitale RM, Zaccaro L, Di Blasio B, Fattorusso R, Isernia C, Amodeo P, Pedone C, Saviano M Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2014 Sep 17; 4(1): 73-81.
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* Deciphering the zinc coordination properties of the prokaryotic zinc finger domain: The solution structure characterization of Ros87 H42A functional mutant (56 views)Palmieri M, Russo L, Malgieri G, Esposito S, Baglivo I, Rivellino A, Farina B, de Paola I, Zaccaro L, Milardi D, Isernia C, Pedone PV, Fattorusso R J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2014 Feb; 131: 30-36.
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* Zinc To Cadmium Replacement In The Prokaryotic Zinc-Finger Domain (56 views)Malgieri G, Palmieri M, Esposito S, Maione V, Russo L, Baglivo I, De Paola I, Milardi D, Diana D, Zaccaro L, Pedone PV, Fattorusso R, Isernia C Metallomics (ISSN: 1756-591x, 1756-5901, 1756-591xelectronic), 2013 Dec 18; 6(1): 96-104.
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* Structural Zn(II) Implies a Switch from Fully Cooperative to Partly Downhill Folding in Highly Homologous Proteins (60 views)Palmieri M, Malgieri G, Russo L, Baglivo I, Esposito S, Netti F, Del Gatto A, De Paola I, Zaccaro L, Pedone PV, Isernia C, Milardi D, Fattorusso R J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2013 Apr 2; 135(13): 5220-5228.
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* Gold nanoparticles capped by a GC-containing peptide functionalized with an RGD motif for integrin targeting (91 views)Scarí G, Porta F, Fascio U, Avvakumova S, Dal Santo V, De Simone M, Saviano M, Leone M, Del Gatto A, Pedone C, Zaccaro L Bioconjugate Chemistry (ISSN: 1520-4812, 1043-1802), 2012 Mar 21; 23(3): 340-349.
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* Zinc to Cadmium Replacement in the A. thaliana SUPERMAN Cys(2)His(2) Zinc Finger Induces Structural Rearrangements of Typical DNA Base Determinant Positions (52 views)Malgieri G, Zaccaro L, Leone M, Bucci E, Esposito S, Baglivo I, Del Gatto A, Russo L, Scandurra R, Pedone PV, Fattorusso R, Isernia C Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2011 Nov; 95(11): 801-810.
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* Design, synthesis and characterization of a peptide able to bind proteins of the KCTD family: implications for KCTD - cullin 3 recognition (50 views)Pirone L, Correale S, De Paola I, Zaccaro L, De Simone G, Vitagliano L, Pedone E, Di Gaetano S J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 May; 17(5): 373-376.
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* Investigation of the Best Conditions to Obtain c(RGDfK) Peptide on Solid Phase (58 views)Saviano M, Del Gatto A, De Simone M, De Paola I, Saviano M, Zaccaro L International Journal Of Peptide Research And Therapeutics (ISSN: 1573-3149, 0929-5666), 2011 Mar; 17(1): 39-45.
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* Reactive astrocytosis-induced perturbation of synaptic homeostasis is restored by nerve growth factor (65 views)Cirillo G, Bianco MR, Colangelo AM, Cavaliere C, Daniele DL, Zaccaro L, Alberghina L, Papa M Neurobiology Of Disease (ISSN: 0969-9961), 2011 Mar; 41(3): 630-639.
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* Evaluation of the anti-angiogenic properties of the new selective alphaVbeta3 integrin antagonist RGDechiHCit (51 views)Santulli G, Basilicata MF, De Simone M, Del Giudice C, Anastasio A, Sorriento D, Saviano M, Del Gatto A, Trimarco B, Pedone C, Zaccaro L, Iaccarino G J Transl Med Journal Of Translational Medicine (ISSN: 1479-5876electronic), 2011 Jan 13; 9: 7-7.
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* AKAP121 downregulation impairs protective cAMP signals, promotes mitochondrial dysfunction, and increases oxidative stress (43 views)Perrino C, Feliciello A, Schiattarella GG, Esposito G, Guerriero R, Zaccaro L, Del Gatto A, Saviano M, Garbi C, Carangi R, Di Lorenzo E, Donato G, Indolfi C, Avvedimento VE, Chiariello M Cardiovascular Research (ISSN: 0008-6363), 2010 Oct; 88(1): 101-110.
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* Solid-phase synthesis of new Trp(Nps)-containing dipeptide derivatives as TRPV1 channel blockers (27 views)Pérez de Vega MJ, García-López MT, Zaccaro L, Royo M, Albericio F, Fernández-Carvajal A, Ferrer-Montiel A, González-Muñiz R Molecules (ISSN: 1420-3049), 2010 Jul 15; 15(7): 4924-4933.
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* Imaging of alpha(v)beta(3) expression by a bifunctional chimeric RGD peptide not cross-reacting with alpha(v)beta(5) (54 views)Zannetti A, Del Vecchio S, Iommelli F, Del Gatto A, De Luca S, Zaccaro L, Papaccioli A, Sommella J, Panico M, Speranza A, Grieco P, Novellino E, Saviano M, Pedone C, Salvatore M Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking), 2009 Sep 15; 15(16): 5224-5233.
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* Imaging of αvβ3 expression by a bifunctional chimeric RGD peptide not cross-reacting with α vβ5 (54 views)Zannetti A, Del Vecchio S, Iommelli F, Del Gatto A, De Luca S, Zaccaro L, Papaccioli A, Sommella J, Panico M, Speranza A, Grieco P, Novellino E, Saviano M, Pedone C, Salvatore M Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking), 2009 Sep 15; 15(16): 5224-5233.
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* MicroPET/CT of mice bearing alpha(v)beta(3)-expressing tumors by a 18F-labeled bifunctional chimeric RGD peptide (64 views)Zannetti A, Iommelli F, Panico M, Del Gatto A, Zaccaro L, Saviano M, Pedone C, Salvatore M, Del Vecchio S Eur J Nucl Med Mol Imaging (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Sep; 36: N/D-N/D.
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* New high yield HPLC purification with ethanol of 18F-RGDEchi and directly injection in mice (45 views)Panico MM, Lang L, Greco A, Greco A, Gargiulo S, Larobina M, Del Vecchio S, Zannetti A, Zaccaro L, Zaccaro L, Del Gatto A, Saviano M, Alfano B, Salvatore M Eur J Nucl Med Mol Imaging (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Sep; 36: N/D-N/D.
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* A new and selective radiolabeled alpha(V)beta(3) peptide antagonist as tracer in tumor diagnosis (46 views)De Luca S, Del Gatto A, Ruvo M, Panico M, Zannetti A, Del Vecchio S, Salvatore M, Pedone C, Saviano M, Zaccaro L Adv Exp Med Biol (ISSN: 0065-2598, 0065-2598print), 2009; 611: 439-440.
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* An Improved Radiolabeling Synthesis of RGDECHI with 18F-Fluoride (46 views)Panico M, Lang L, Del Vecchio S, Nardelli A, Castaldi E, Zaccaro L, Del Gatto A, Saviano M, Zannetti A, Larobina M, Gargiulo S, Pedone C, Salvatore M Eur J Nucl Med Mol Imaging (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Oct; 35: N/D-N/D.
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* Development of new molecules that compete with p53 for Binding to TFIIH (44 views)Zaccaro L, Del Gatto A, Saviano M, Langella E, Langlois C, Di Lello P, Baffreau J, Mas C, Legault P, Omichinski JG, Pedone C J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
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* A New Nerve Growth Factor (ngf)-Mimetic Peptide Active On Neuropathic Pain In Rats (56 views)Colangelo AM, Bianco MR, Vitagliano L, Cavaliere C, Cirillo G, De Gioia L, Diana D, Colombo D, Redaelli C, Zaccaro L, Morelli G, Papa M, Sarmientos P, Alberghina L, Martegani E Journal Of Neuroscience (ISSN: 0270-6474, 0270-0647), 2008 Mar 12; 28(11): 2698-2709.
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* The Prokaryotic Cys2his2 Zinc Finger Domain Adopts A Novel Fold As Revealed By The Solution Structure Of Agrobacterium Tumefaciens Ros Dna Binding Domain (41 views)Malgieri G, Russo L, Esposito S, Baglivo I, Zaccaro L, Pedone EM, Di Blasio B, Isernia C, Pedone PV, Fattorusso R Proc Natl Acad Sci U S A (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2007 Oct 30; 104(44): 17341-17346.
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* In vivo imaging of alpha(v) beta(3) integrin expression with a radiolabeled chimeric RGD peptide (48 views)Del Vecchio S, Zannetti A, Panico M, Speranza A, Iommelli F, Papaccioli A, Sommella J, Lettieri A, Saviano M, Zaccaro L, Del Gatto A, Lang L, Pedone C, Salvatore M Eur J Nucl Med Mol Imaging (ISSN: 1619-7070, 1619-7089, 0340-6997), 2007 Oct; 34: N/D-N/D.
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* A new and selective radiolabeled alpha(v)beta 3 peptide antagonist as tracer in tumor diagnosis (41 views)Zaccaro L, Del Gatto A, De Luca S, Ruvo M, Zannetti A, Del Vecchio S, Salvatore M, Pedone C, Saviano M Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2007; 88(4): N/D-N/D.
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* A novel type of zinc finger DNA binding domain in the Agrobacterium tumefaciens transcriptional regulator Ros (40 views)Esposito S, Baglivo I, Malgieri G, Russo L, Zaccaro L, D'Andrea LD, Mammucari M, Di Blasio B, Isernia C, Fattorusso R, Pedone PV Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2006 Sep 29; 45(34): 10394-10405.
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* Novel And Selective Alpha (v) Beta3 Receptor Peptide Antagonist: Design, Synthesis, And Biological Behavior (96 views)Del Gatto A, Zaccaro L, Grieco P, Novellino E, Zannetti A, Del Vecchio S, Iommelli F, Salvatore M, Pedone C, Saviano M J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Jun 1; 49(11): 3416-3420.
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* Antisense PNA and PNA-peptide conjugates for the modulation of beta-globin gene splicing (39 views)Romanelli A, Pensato S, Di Niola E, Feriotto G, Salvatori F, Breveglieri G, Zaccaro L, Saviano M, Gambari R, Pedonel C, Benedetti E Understanding Biology Using Peptides, 2006; N/D: N/D-N/D.
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* Novel and selective alpha v beta 3 receptor peptide antagonist: Design, synthesis and biological behaviour (46 views)Del Gatto A, Zaccaro L, Zannetti A, Del Vecchio S, Benedetti E, Salvatore M, Pedone C, Saviano M J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006; 12: N/D-N/D.
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* Characterization of a novel RGD-containing peptide with improved selectivity for imaging alpha v beta 3 integrin expression (53 views)Del Vecchio S, Zannetti A, Del Gatto A, Grieco P, Iommelli F, Zaccaro L, Panico M, Saviano M, Blystone SD, Pedone C, Salvatore M Eur J Nucl Med Mol Imaging (ISSN: 1619-7070, 1619-7089, 0340-6997), 2005 Sep; 32: N/D-N/D.
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* Erratum: A new class of foldamers based on cis-γ-amino-L-proline (Journal of the American Chemical Society (2004) 126 (6048-6057)) (29 views)Farrera-Sinfreu J, Zaccaro L, Vidal D, Salvatella X, Giralt E, Pons M, Albericio F, Royo M J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2005; 127(1): 474-474.
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* A New Class of Foldamers Based on cis-γ-Amino-L-proline (74 views)Farrera-Sinfreu J, Zaccaro L, Vidal D, Salvatella X, Giralt E, Pons M, Albericio F, Royo M J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2004 May 19; 126(19): 6048-6057.
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* A synthetic peptide reproducing the mitochondrial targeting motif of AKAP121: A conformational study (60 views)De Capua A, Del Gatto A, Zaccaro L, Saviano G, Carlucci A, Livigni A, Gedressi C, Tancredi T, Pedone C, Saviano M Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 459-466.
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* Synthetic Peptides Able To Modulate The Interaction Of Akap121 With Mitochondria (35 views)Del Gatto A, De Capua A, Saviano M, Zaccaro L, Benedetti E, Pedone C, Tancredi T, Feliciello A, Affaitati A, Avvedimento EV N/D, 2004; 76: 459-466.
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* NMR structure of the single QALGGH zinc finger domain from the Arabidopsis thaliana SUPERMAN protein (60 views)Isernia C, Bucci E, Leone M, Zaccaro L, Di Lello P, Digilio G, Esposito S, Saviano M, Di Blasio B, Pedone C, Pedone PV, Fattorusso R Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003 Mar 3; 4(2-3): 171-180.
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* Synthetic peptides mimicking the interleukin-6/gp130 interaction: a two-helix bundle system. Design and conformational studies (46 views)Zaccaro L, Bucci E, Vitale RM, Perretta G, Fattorusso R, Benedetti E, Saviano M, Pedone C J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2003 Feb; 9(2): 105-105.
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* Synthetic peptides mimicking the interleukin-6/gp130 interaction: A two-helix bundle system. Design and confirmational studies (44 views)Zaccaro L, Bucci E, Vitale RM, Perretta G, Fattorusso R, Benedetti E, Saviano M, Pedone C J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2003; 9(2): 90-105.
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* The Arabidopsis SUPERMAN protein is able to specifically bind DNA through its single Cys(2)-His(2) zinc finger motif (37 views)Dathan N, Zaccaro L, Esposito S, Isernia C, Omichinski JG, Riccio A, Pedone C, Di Blasio B, Fattorusso R, Pedone PV Nucleic Acids Res (ISSN: 0305-1048, 1362-4962, 1362-4962electronic), 2002 Nov 15; 30(22): 4945-4951.
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Conformational Behaviour Of C (alpha, Alpha)-Diphenylglycine: Folded Vs. Extended Structures In Dphig-Containing Tripeptides (50 views)Pavone V, Lombardi A, Saviano M, Nastri F, Zaccaro L, Maglio O, Pedone C, Omote Y, Yamanaka Y, Yamada T J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 1998 Feb; 4(1): 21-32.
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Conformational Behaviour Of C-Alpha-Alpha-Diphenylglicine. Folded Versus Extended Structures In Dfg-Containing Tripeptides (30 views)Pavone V, Lombardi A, Saviano M, Nastri F, Zaccaro L, Maglio O, Pedone C, Omote Y, Yamanaka Y, Yamada T N/D, 1998; 4: 21-32.
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Experimental evidence at atomic resolution for intramolecular N- H···π (phenyl) interactions in a family of amino acid derivatives (40 views)Crisma M, Formaggio F, Valle G, Toniolo C, Saviano M, Iacovino R, Zaccaro L, Benedetti E Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1997; 42(1): 1-6.
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Mixed conformation in C(α, α)-disubstituted tripeptides: X-ray crystal structures of Z-Aib-Dph-Gly-OMe and Bz-Dph-Dph-Gly-OMe (34 views)Pavone V, Lombardi A, Saviano M, Di Blasio B, Nastri F, Fattorusso R, Zaccaro L, Maglio O, Yamada T, Omote Y Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1994 Dec; 34(12): 1595-1604.
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beta-Cyclodextrins as potent bioactive delivery system (37 views)Rossi F, Zaccaro L, Di Blasio B, Pavone V, Maglio O, Saviano M, Pedone C, Cucinotta V, Impellizzeri G, Rizzarelli E, Vecchio G Peptides, 1992; N/D: 577-578.
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In Vitro Activity Of The Alpha(v)beta(3) Integrin Antagonist Rgdechi-Hcit On Malignant Melanoma Cells (43 views)Pisano M, De Paola I, Nieddu V, Sassu I, Cossu S, Galleri G, Del Gatto A, Budroni M, Cossu A, Saviano M, Palmieri G, Zaccaro L, Rozzo C Anticancer Research (ISSN: 0250-7005, 0250-0700), N/D; 33(3): 871-880.
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Structure-Based Design Of A Potent Artificial Transactivation Domain Based On P53 Atas (63 views)Langlois C, Del Gatto A, Arseneault G, Lafrance-Vanasse J, De Simone M, Morse T, de Paola I, Lussier-Price M, Legault P, Pedone C, Zaccaro L, Omichinski JG J Am Chem Soc (ISSN: 1520-5126, 0002-2786, 0002-7863), N/D; 134(3): 1715-1723.
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63 Records ( 46 excluding Abstracts and Conferences). Total impact factor: 263.731 ( 201.373 excluding Abstracts and Conferences). Total 5-year impact factor: 277.438 ( 216.36 excluding Abstracts and Conferences).
Your bibliography query: [author] ZACCARO_L
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