Characterization of nigrostriatal dysfunction in spinocerebellar ataxia 17 (379 views)
Mov Disord (ISSN: 0885-3185, 1531-8257, 0885-3185linking), 2006 Jun; 21(6): 872-875.
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Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 3.323, 5-year impact factor: 5.251
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-33745838247&partnerID=40&md5=620916ce46aa8eaae352bd039dd8092f
Keywords: [123i]-Fp-Cit Spect, Nigrostriatal Dopaminergic Pathway, Sca17, Spinocerebellar Ataxia, Adenine, Cytosine, Dopamine Transporter, Guanine, Levodopa, Nortropane Derivative, Tata Binding Protein, Adult, Article, Caudate Nucleus, Clinical Article, Controlled Study, Correlation Analysis, Disease Severity, Dopaminergic System, Family, Female, Heterozygote, Human, Neuroimaging, Nigroneostriatal System, Parkinsonism, Phenotype, Priority Journal, Putamen, Single Photon Emission Computer Tomography, Spinocerebellar Degeneration, Trinucleotide Repeat, Corpus Striatum, Substantia Nigra, Tata-Box Binding Protein, Emission-Computed, Single-Photon, Trinucleotide Repeat Expansion,
Affiliations:
*** IBB - CNR ***
Department of Neurological Sciences, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy
Biostructure and Bioimaging Institute, CNR, Naples, Italy
Department of Biomorphological and Functional Sciences, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy
IRCCS Fondazione S. Maugeri, Telese, Italy
Regional Neurogenetic Center AS6, Lamezia Terme, Italy
References:
Not available.
Mov Disord (ISSN: 0885-3185, 1531-8257, 0885-3185linking), 2006 Jun; 21(6): 872-875.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 3.323, 5-year impact factor: 5.251
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-33745838247&partnerID=40&md5=620916ce46aa8eaae352bd039dd8092f
Keywords: [123i]-Fp-Cit Spect, Nigrostriatal Dopaminergic Pathway, Sca17, Spinocerebellar Ataxia, Adenine, Cytosine, Dopamine Transporter, Guanine, Levodopa, Nortropane Derivative, Tata Binding Protein, Adult, Article, Caudate Nucleus, Clinical Article, Controlled Study, Correlation Analysis, Disease Severity, Dopaminergic System, Family, Female, Heterozygote, Human, Neuroimaging, Nigroneostriatal System, Parkinsonism, Phenotype, Priority Journal, Putamen, Single Photon Emission Computer Tomography, Spinocerebellar Degeneration, Trinucleotide Repeat, Corpus Striatum, Substantia Nigra, Tata-Box Binding Protein, Emission-Computed, Single-Photon, Trinucleotide Repeat Expansion,
Affiliations:
*** IBB - CNR ***
Department of Neurological Sciences, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy
Biostructure and Bioimaging Institute, CNR, Naples, Italy
Department of Biomorphological and Functional Sciences, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy
IRCCS Fondazione S. Maugeri, Telese, Italy
Regional Neurogenetic Center AS6, Lamezia Terme, Italy
References:
Not available.
Characterization of nigrostriatal dysfunction in spinocerebellar ataxia 17
Extrapyramidal signs are a main feature of spinocerebellar ataxia 17 (SCA17). However, the extent of dopaminergic: dysfunction and its correlation with parkinsonian signs are not fully understood. In order to define this, we investigated five subjects from three different families with a pathological CAG/CAA expansion in the TATA-binding protein gene (SCA17), ranging from asymptomatic carrier to patient with advanced disease, by FP-CIT SPECT. Nigrostriatal dysfunction was present in patients manifesting a fully developed phenotype but not in preclinical and early stages. Dopamine transporter reduction was symmetrical and uniform in caudate and putamen and it correlated with the clinical severity of ataxia. © 2006 Movement Disorder Society.
Extrapyramidal signs are a main feature of spinocerebellar ataxia 17 (SCA17). However, the extent of dopaminergic: dysfunction and its correlation with parkinsonian signs are not fully understood. In order to define this, we investigated five subjects from three different families with a pathological CAG/CAA expansion in the TATA-binding protein gene (SCA17), ranging from asymptomatic carrier to patient with advanced disease, by FP-CIT SPECT. Nigrostriatal dysfunction was present in patients manifesting a fully developed phenotype but not in preclinical and early stages. Dopamine transporter reduction was symmetrical and uniform in caudate and putamen and it correlated with the clinical severity of ataxia. © 2006 Movement Disorder Society.
Characterization of nigrostriatal dysfunction in spinocerebellar ataxia 17
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Characterization of nigrostriatal dysfunction in spinocerebellar ataxia 17
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* Supratentorial and infratentorial damage in spinocerebellar ataxia 2: a diffusion-weighted MRI study (462 views)
Mov Disord (ISSN: 0885-3185, 1531-8257, 0885-3185linking), 2014 May; 29(6): 780-786.
Impact Factor: 5.68
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Testi S, Peluso S, Fabrizi GM, Antenora A, Russo CV, Pappata S, Padovani A, Ferrarini M, Filla A
* A novel PSEN1 mutation in a patient with sporadic early-onset Alzheimer's disease and prominent cerebellar ataxia (343 views)
J Alzheimers Dis (ISSN: 1387-2877, 1387-2877linking), 2014; 41(3): 709-714.
Impact Factor: 4.151
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De Rosa A, Pappata S, Pellegrino T, De Leva MF, Maddaluno G, Fiumara G, Carotenuto R, Petretta M, Filla A, De Michele G, Cuocolo A
* Reduced Cardiac 123i-Metaiodobenzylguanidine Uptake In Patients With Spinocerebellar Ataxia Type 2: A Comparative Study With Parkinson'S Disease (732 views)
Eur J Nucl Med (ISSN: 1619-7089, 1619-7070, 0340-6997), 2013 Dec; 40(12): 1914-1921.
Impact Factor: 2.692
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Greco A, Zannetti A, Coda ARD, Albanese S, Nardelli A, Roca A, Pappata S, Brunetti A, Cuocolo A
* Effects of Thyroid Blockade on Brain Imaging of Dopamine Transporter in Normal Mice (409 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2013 Oct; 40: N/D-N/D.
Impact Factor: 5.217
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Saccà F, Marsili A, Pane C, Brunetti A, De Michele G, Puorro G, Quarantelli M, Russo CV, Salvatore E, Filla A
* A Pilot, Randomized, Placebo-Controlled, Trial of Lithium in Spinocerebellar Ataxia Type (336 views)
Neurology (ISSN: 0028-3878, 1526-632x, 1526-632xelectronic), 2013 Feb 12; 80: 5-5.
Impact Factor: 8.303
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Erro R, Pappata S, Amboni M, Vicidomini C, Longo K, Santangelo G, Picillo M, Vitale C, Moccia M, Giordano F, Brunetti A, Pellecchia MT, Salvatore M, Barone P
* Anxiety is associated with striatal dopamine transporter availability in newly diagnosed untreated Parkinson's disease patients (733 views)
Parkinsonism Relat D (ISSN: 1873-5126, 1353-8020, 1873-5126electronic), 2012 Nov; 18(9): 1034-1038.
Impact Factor: 3.274
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Pellegrino T, Pappata S, De Rosa A, De Leva M, Tuccillo M, Boemio A, Filla A, De Michele G, Cuocolo A
* Cardiac Metaiodobenzylguanidine Scintigraphy in Patients With Spinocerebellar Ataxia Type (273 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2012 Oct; 39: N/D-N/D.
Impact Factor: 5.114
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Sasaki T, Ito H, Kimura Y, Arakawa R, Takano H, Seki C, Kodaka F, Fujie S, Takahata K, Nogami T, Suzuki M, Fujiwara H, Takahashi H, Nakao R, Fukumura T, Varrone A, Halldin C, Nishikawa T, Suhara T
* Quantification of dopamine transporter in human brain using PET with 18F-FE-PE2I (706 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2012 Jul; 53(7): 1065-1073.
Impact Factor: 5.774
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Antonini A, Vitale C, Barone P, Cilia R, Righini A, Bonuccelli U, Abbruzzese G, Ramat S, Petrone A, Quatrale R, Marconi R, Ceravolo R, Stefani A, Lopiano L, Zappia M, Capus L, Morgante L, Tamma F, Tinazzi M, Colosimo C, Guerra UP, Valzania F, Fagioli G, Distefano A, Bagnato A, Feggi L, Anna S, Maria Teresa Rosaria De Cr, Nobili F, Mazzuca N, Baldari S, Eleopra R, Bestetti A, Benti R, Varrone A, Volterrani D, Massa R, Stocchi F, Schillaci O, Dore F, Zibetti M, Castellano G, Battista SG, Giorgetti G
* The relationship between cerebral vascular disease and parkinsonism: The VADO study (607 views)
Parkinsonism Relat D (ISSN: 1353-8020, 1873-5126, 1873-5126electronic), 2012; 18(6): 775-780.
Impact Factor: 3.274
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Varrone A, Stepanov V, Nakao R, Toth M, Gulyas B, Emond P, Deloye JB, Vercouillie J, Stabin MG, Jonsson C, Guilloteau D, Halldin C
* Imaging of the striatal and extrastriatal dopamine transporter with 18F-LBT-999: Quantification, biodistribution, and radiation dosimetry in nonhuman primates (623 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2011 Sep 1; 52(8): 1313-1321.
Impact Factor: 6.381
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Varrone A, Halldin C
Molecular imaging of the dopamine transporter (647 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2010 Sep 1; 51(9): 1331-1334.
Impact Factor: 7.022
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Darcourt J, Booij J, Tatsch K, Varrone A, Borght TV, Kapucu OL, Nagren K, Nobili F, Walker Z, Van Laere K
* EANM procedure guidelines for brain neurotransmission SPECT using 123I-labelled dopamine transporter ligands, version (1192 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2010 Feb; 37(2): 443-450.
Impact Factor: 5.036
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Varrone A, Sjoholm N, Eriksson L, Gulyas B, Halldin C, Farde L
* Advancement in PET quantification using 3D-OP-OSEM point spread function reconstruction with the HRRT (1281 views) (PDF 287 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Oct; 36(10): 1639-1650.
Impact Factor: 4.531
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Varrone A, Steiger C, Schou M, Takano A, Finnema SJ, Guilloteau D, Gulyas B, Halldin C
* In vitro autoradiography and in vivo evaluation in cynomolgus monkey of [18F]FE-PE2I, a new dopamine transporter PET radioligand (1073 views)
Synapse (ISSN: 0887-4476), 2009 Oct; 63(10): 871-880.
Impact Factor: 2.557
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Varrone A, Sansone V, Pellecchia MT, Amboni M, Salvatore E, De Michele G, Filla A, Barone P, Pappata S, Salvatore M
* Comparison between a dual-head and a brain-dedicated SPECT system in the measurement of the loss of dopamine transporters with [123I]FP-CIT (444 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Jul; 35(7): 1343-1349.
Impact Factor: 4.532
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Salvatore E, Mollica C, Ianniciello M, Varrone A, Sansone V, Salvatore M, De Michele G, Filla A, Pappata S
* Spinocerebellar ataxia 2: A brain diffusion weighted MRI study (319 views)
Neurology (ISSN: 0028-3878, 1526-632x, 1526-632xelectronic), 2007 Mar 20; 68(12): N/D-N/D.
Impact Factor: 6.014
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Pellecchia MT, Varrone A, Annesi G, Amboni M, Cicarelli G, Sansone V, Annesi F, Rocca FE, Vitale C, Pappata S, Quattrone A, Barone P
* Parkinsonism and essential tremor in a family with pseudo-dominant inheritance of PARK2: An FP-CIT SPECT study (524 views)
Mov Disord (ISSN: 0885-3185, 1531-8257, 0885-3185linking), 2007 Mar 15; 22(4): 559-563.
Impact Factor: 3.207
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Varrone A, Sansone V, Pellecchia MT, Amboni M, Vitale C, Salvatore E, De Michele G, Garavaglia B, Annesi G, Brice A, Pappata S, Barone P, Salvatore M
* Longitudinal changes of dopamine transporter density in early-onset parkin disease measured with [I-123]FP-CIT SPECT (281 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Sep; 33: N/D-N/D.
Impact Factor: 4.041
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Sansone V, Varrone A, Pellecchia MT, Amboni M, Salvatore E, De Michele G, Filla A, Barone P, Pappata S, Salvatore M
* Comparison Of A Dual-Headed And A Brain-Dedicated SPECT Camera In The Ability To Measure The Loss Of Dopamine Transporters With [123I]FP-CIT (360 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2005 Sep; 32: N/D-N/D.
Impact Factor: 3.883
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Varrone A, Salvatore E, Sansone V, De Michele G, Filla A, Pappata S, Salvatore M
* [123I]FP-CIT SPECT Study Of The Striatal Dopamine Transporter Density In Patients With Idiopathic Late Onset Cerebellar Ataxia And MSA-C (292 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2005 Sep; 32: N/D-N/D.
Impact Factor: 3.883
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Varrone A, Pellecchia MT, Amboni M, Sansone V, Salvatore E, Ghezzi D, Garavaglia B, Brice A, Brunetti A, Bonavita V, De Michele G, Salvatore M, Pappata S, Barone P
* Imaging of dopaminergic dysfunction with [123I]FP-CIT SPECT in early-onset parkin disease (4279 views)
Neurology (ISSN: 0028-3878, 1526-632x, 1526-632xelectronic), 2004 Dec 14; 63(11): 2097-2103.
Impact Factor: 5.973
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Varrone A, Salvatore E, De Michele G, Barone P, Sansone V, Pellecchia MT, Castaldo I, Coppola G, Brunetti A, Salvatore M, Pappata S, Filla A
* Reduced Striatal [123I]FP-CIT Binding in SCA2 Patients without Parkinsonism (571 views)
Annals Of Neurology, 2004 Mar; 55(3): 426-430.
Impact Factor: 11.91
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34 Records (26 excluding Abstracts).
Total impact factor: 153.105 (114.091 excluding Abstracts).
Total 5 year impact factor: 151.819 (111.133 excluding Abstracts).
Total impact factor: 153.105 (114.091 excluding Abstracts).
Total 5 year impact factor: 151.819 (111.133 excluding Abstracts).
379 views. Last view on Saturday 12 October 2024, 16:47:57
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