Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (585 views)
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
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Paper type: Journal Article, Comparative Study, Research Support, Non-U. S. Gov'T,
Impact factor: 1.995, 5-year impact factor: 1.817
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-23044437134&partnerID=40&md5=c106ba137fd297901c611eaa015605eb
Keywords: β-Amyloid, σ1 Receptor Agonists, Neuronal Apoptosis, 1 Phenylcyclohexanecarboxylic Acid 2 Morpholinoethyl Ester, 2 (4 Morpholinethyl)1 Phenylcyclohexanecarboxylate, 2 [4 Methoxy 3 (2 Phenylethoxy)phenyl] N, N Dipropylethylamine, 7 Dinitro 2, 3 Quinoxalinedione, Amyloid Beta Protein[25-35], Carboxylic Acid Derivative, Dizocilpine, Methyl 2 [1 Adamantyl(methyl)amino] Methyl 1 Phenylcyclopropanecarboxylate, Mr 22, Opiate Agonist, Opiate Antagonist, Protein Bax, Sigma Receptor Ligand, Unclassified Drug, Alzheimer Disease, Animal Cell, Article, Cell Death, Controlled Study, Cytotoxicity, Drug Antagonism, Drug Synthesis, Neuroprotection, Nonhuman, Priority Journal, Amyloid Beta-Protein, Anisoles, Bcl-2-Associated X Protein, Blotting, Western, Cell Count, Cell Survival, Cultured, Cerebral Cortex, Dose-Response Relationship, Drug Interactions, Embryo, Excitatory Amino Acid Antagonists, Neuroprotective Agents, Peptide Fragments, Propylamines, Proto-Oncogene Proteins C-Bcl-2, Amyloid Beta-Peptides, Inhibitors, Pharmacology, Drug Effects, Cytology, Mammalian, Metabolism,
Affiliations:
*** IBB - CNR ***
Department of Pharmaceutical Sciences, University of Catania, Catania, Italy
I.B.B., CNR-Catania, Catania, Italy
Cellular Neurobiology Research Branch, NIDA, NIH, Baltimore, MD, United States
References:
Hardy, J., Selkoe, D.J., The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics (2002) Science, 297, pp. 353-35
Loo, D.T., Copani, A., Pike, C.J., Whittemore, E.R., Walencewicz, A.J., Cotman, C.W., Apoptosis is induced by beta-amyloid in cultured central nervous system neurons (1993) Proc Natl Acad Sci USA, 90, pp. 7951-7955
Smale, G., Nichols, N.R., Brady, D.R., Finch, C.E., Horton Jr., W.E., Evidence for apoptotic cell death in Alzheimer's disease (1995) Exp Neurol, 133, pp. 225-230
Caricasole, A., Copani, A., Caraci, F., Aronica, E., Rozemuller, A.J., Caruso, A., Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (2004) J Neurosci, 24, pp. 6021-6027
Guitart, X., Codony, X., Monroy, X., Sigma receptors: Biology and therapeutic potential (2004) Psychopharmacology, 174, pp. 301-319
Maurice, T., Beneficial effect of the sigma1 receptor agonist PRE-084 against the spatial learning deficits in aged rats (2001) Eur J Pharmacol, 431, pp. 223-227
Maurice, T., Su, T.P., Privat, A., Sigma1 (σ1) receptor agonists and neurosteroids attenuate β25-35-amyloid peptide-induced amnesia in mice through a common mechanism (1998) Neuroscience, 83, pp. 413-428
Urani, A., Romieu, P., Roman, F.J., Maurice, T., Enhanced antidepressant effect of sigma1 (σ) receptor agonists in beta(25-35)-amyloid peptide-treated mice (2002) Behav Brain Res, 134, pp. 239-247
Kume, T., Nishikawa, H., Taguchi, R., Hashino, A., Katsuki, H., Kaneko, S., Antagonism of NMDA receptors by sigma receptor ligands attenuates chemical ischemia-induced neuronal death in vitro (2002) Eur J Pharmacol, 455, pp. 91-100
Takahashi, H., Kirsch, J.R., Hashimoto, K., London, E.D., Koehler, R.C., PPBP [4-phenyl-1-(4-phenylbutyl) piperidine] decreases brain injury after transient focal ischemia in rats (1996) Stroke, 27, pp. 2120-2123
Copani, A., Condorelli, F., Caruso, A., Vancheri, C., Sala, A., Giuffrida Stella, A.M., Mitotic signaling by beta-amyloid causes neuronal death (1999) FASEB J, 13, pp. 2225-2234
Marrazzo, A., Prezzavento, O., Pappalardo, M.S., Bousquet, E., Iadanza, M., Pike, V.W., Synthesis of (+)- And(-)-cis-2-[(1-adamantylamino)-methyl]-1 phenylcyclopropane derivatives as high affinity probes for sigma1 and sigma2 binding sites (2002) Farmaco, 57, pp. 45-53
Chaki, S., Okuyama, S., Ogawa, S., Tanaka, M., Muramatsu, M., Nakazato, Solubilization and characterization of binding sites for [3H]NE-100, a novel and potent sigma 1 ligand, from guinea pig brain (1996) Life Sci, 59, pp. 1331-1340
Su, T.P., Wu, X.Z., Cone, E.J., Shukla, K., Gund, T.M., Sigma compounds derived from phencyclidine: Identification of PRE-084, a new, selective sigma ligand (1991) J Pharmacol Exp Ther, 259, pp. 543-550
Church, J., Fletcher, E.J., Blockade by sigma site ligands of high voltage-activated Ca2+ channels in rat and mouse cultured, hippocampal pyramidal neurons (1995) Br J Pharmacol, 116, pp. 2801-2810
Morin-Surun, M.P., Collin, T., Denavit-Saubié, M., Baulieu, E.-E., Monnet, F.P., Intracellular σ1 receptor modulates phospholipase C and protein kinase C activities in the brainstem (1999) Proc Natl Acad Sci USA, 96, pp. 8196-8199
Ovalle, S., Zamanillo, D., Andreu, F., Farre, A.J., Guitart, X., Fibroblast growth factor-2 is selectively modulated in the rat brain by E-5842, a preferential sigma-1 receptor ligand and putative atypical antipsychotic (2001) Eur J Neurosci, 13, pp. 909-915
Copani, A., Bruno, V., Battaglia, G., Leanza, G., Pellitteri, R., Activation of metabotropic glutamate receptors protects cultured neurons against apoptosis induced by beta-amyloid peptide (1995) Mol Pharmacol, 47, pp. 890-897
Xie, J., Guo, Q., Zhu, H., Wooten, M.W., Mattson, M.P., Protein kinase C iota protects neural cells against apoptosis induced by amyloid beta-peptide (2000) Brain Res Mol Brain Res, 82, pp. 107-113
Mattson, M.P., Tomaselli, K.J., Rydel, R.E., Calcium-destabilizing and neurodegenerative effects of aggregated beta-amyloid peptide are attenuated by basic FGF (1993) Brain Res, 621, pp. 35-49
Maurice, T., Improving Alzheimer's disease-related cognitive deficits with sigmal receptor agonists (2002) Drug News Perspect, 15, pp. 617-625
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Comparative Study, Research Support, Non-U. S. Gov'T,
Impact factor: 1.995, 5-year impact factor: 1.817
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-23044437134&partnerID=40&md5=c106ba137fd297901c611eaa015605eb
Keywords: β-Amyloid, σ1 Receptor Agonists, Neuronal Apoptosis, 1 Phenylcyclohexanecarboxylic Acid 2 Morpholinoethyl Ester, 2 (4 Morpholinethyl)1 Phenylcyclohexanecarboxylate, 2 [4 Methoxy 3 (2 Phenylethoxy)phenyl] N, N Dipropylethylamine, 7 Dinitro 2, 3 Quinoxalinedione, Amyloid Beta Protein[25-35], Carboxylic Acid Derivative, Dizocilpine, Methyl 2 [1 Adamantyl(methyl)amino] Methyl 1 Phenylcyclopropanecarboxylate, Mr 22, Opiate Agonist, Opiate Antagonist, Protein Bax, Sigma Receptor Ligand, Unclassified Drug, Alzheimer Disease, Animal Cell, Article, Cell Death, Controlled Study, Cytotoxicity, Drug Antagonism, Drug Synthesis, Neuroprotection, Nonhuman, Priority Journal, Amyloid Beta-Protein, Anisoles, Bcl-2-Associated X Protein, Blotting, Western, Cell Count, Cell Survival, Cultured, Cerebral Cortex, Dose-Response Relationship, Drug Interactions, Embryo, Excitatory Amino Acid Antagonists, Neuroprotective Agents, Peptide Fragments, Propylamines, Proto-Oncogene Proteins C-Bcl-2, Amyloid Beta-Peptides, Inhibitors, Pharmacology, Drug Effects, Cytology, Mammalian, Metabolism,
Affiliations:
*** IBB - CNR ***
Department of Pharmaceutical Sciences, University of Catania, Catania, Italy
I.B.B., CNR-Catania, Catania, Italy
Cellular Neurobiology Research Branch, NIDA, NIH, Baltimore, MD, United States
References:
Hardy, J., Selkoe, D.J., The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics (2002) Science, 297, pp. 353-35
Loo, D.T., Copani, A., Pike, C.J., Whittemore, E.R., Walencewicz, A.J., Cotman, C.W., Apoptosis is induced by beta-amyloid in cultured central nervous system neurons (1993) Proc Natl Acad Sci USA, 90, pp. 7951-7955
Smale, G., Nichols, N.R., Brady, D.R., Finch, C.E., Horton Jr., W.E., Evidence for apoptotic cell death in Alzheimer's disease (1995) Exp Neurol, 133, pp. 225-230
Caricasole, A., Copani, A., Caraci, F., Aronica, E., Rozemuller, A.J., Caruso, A., Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (2004) J Neurosci, 24, pp. 6021-6027
Guitart, X., Codony, X., Monroy, X., Sigma receptors: Biology and therapeutic potential (2004) Psychopharmacology, 174, pp. 301-319
Maurice, T., Beneficial effect of the sigma1 receptor agonist PRE-084 against the spatial learning deficits in aged rats (2001) Eur J Pharmacol, 431, pp. 223-227
Maurice, T., Su, T.P., Privat, A., Sigma1 (σ1) receptor agonists and neurosteroids attenuate β25-35-amyloid peptide-induced amnesia in mice through a common mechanism (1998) Neuroscience, 83, pp. 413-428
Urani, A., Romieu, P., Roman, F.J., Maurice, T., Enhanced antidepressant effect of sigma1 (σ) receptor agonists in beta(25-35)-amyloid peptide-treated mice (2002) Behav Brain Res, 134, pp. 239-247
Kume, T., Nishikawa, H., Taguchi, R., Hashino, A., Katsuki, H., Kaneko, S., Antagonism of NMDA receptors by sigma receptor ligands attenuates chemical ischemia-induced neuronal death in vitro (2002) Eur J Pharmacol, 455, pp. 91-100
Takahashi, H., Kirsch, J.R., Hashimoto, K., London, E.D., Koehler, R.C., PPBP [4-phenyl-1-(4-phenylbutyl) piperidine] decreases brain injury after transient focal ischemia in rats (1996) Stroke, 27, pp. 2120-2123
Copani, A., Condorelli, F., Caruso, A., Vancheri, C., Sala, A., Giuffrida Stella, A.M., Mitotic signaling by beta-amyloid causes neuronal death (1999) FASEB J, 13, pp. 2225-2234
Marrazzo, A., Prezzavento, O., Pappalardo, M.S., Bousquet, E., Iadanza, M., Pike, V.W., Synthesis of (+)- And(-)-cis-2-[(1-adamantylamino)-methyl]-1 phenylcyclopropane derivatives as high affinity probes for sigma1 and sigma2 binding sites (2002) Farmaco, 57, pp. 45-53
Chaki, S., Okuyama, S., Ogawa, S., Tanaka, M., Muramatsu, M., Nakazato, Solubilization and characterization of binding sites for [3H]NE-100, a novel and potent sigma 1 ligand, from guinea pig brain (1996) Life Sci, 59, pp. 1331-1340
Su, T.P., Wu, X.Z., Cone, E.J., Shukla, K., Gund, T.M., Sigma compounds derived from phencyclidine: Identification of PRE-084, a new, selective sigma ligand (1991) J Pharmacol Exp Ther, 259, pp. 543-550
Church, J., Fletcher, E.J., Blockade by sigma site ligands of high voltage-activated Ca2+ channels in rat and mouse cultured, hippocampal pyramidal neurons (1995) Br J Pharmacol, 116, pp. 2801-2810
Morin-Surun, M.P., Collin, T., Denavit-Saubié, M., Baulieu, E.-E., Monnet, F.P., Intracellular σ1 receptor modulates phospholipase C and protein kinase C activities in the brainstem (1999) Proc Natl Acad Sci USA, 96, pp. 8196-8199
Ovalle, S., Zamanillo, D., Andreu, F., Farre, A.J., Guitart, X., Fibroblast growth factor-2 is selectively modulated in the rat brain by E-5842, a preferential sigma-1 receptor ligand and putative atypical antipsychotic (2001) Eur J Neurosci, 13, pp. 909-915
Copani, A., Bruno, V., Battaglia, G., Leanza, G., Pellitteri, R., Activation of metabotropic glutamate receptors protects cultured neurons against apoptosis induced by beta-amyloid peptide (1995) Mol Pharmacol, 47, pp. 890-897
Xie, J., Guo, Q., Zhu, H., Wooten, M.W., Mattson, M.P., Protein kinase C iota protects neural cells against apoptosis induced by amyloid beta-peptide (2000) Brain Res Mol Brain Res, 82, pp. 107-113
Mattson, M.P., Tomaselli, K.J., Rydel, R.E., Calcium-destabilizing and neurodegenerative effects of aggregated beta-amyloid peptide are attenuated by basic FGF (1993) Brain Res, 621, pp. 35-49
Maurice, T., Improving Alzheimer's disease-related cognitive deficits with sigmal receptor agonists (2002) Drug News Perspect, 15, pp. 617-625
Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity
Prolonged exposure of cultured cortical neurons to the residue 25-35 fragment of β-amyloid protein, in the presence of dizocilpine, an antagonist of the N-methyl-D-aspartate receptor, and of 6,7-dinitroquinoxaline- 2,3-dione, an antagonist of α-amino-3-hydroxy-5-methylisoxazole-4- propionate receptors, resulted in the expression of the proapoptotic protein Bax and neuronal death. Beta-amyloid protein(25-35)-induced neuronal death was substantially attenuated by the σ1 receptor agonist 2-(4-morpholinethyl)1-phenylcyclohexanecarboxylate. The neuroprotective action of 2-(4-morpholinethyl)1-phenylcyclohexanecarboxylate was mimicked by the σ1 ligand methyl (1S,2R)-2-[1-adamantyl(methyl)amino]methyl-1- phenylcyclopropanecarboxylate and was antagonized by the σ1 receptor antagonist N,N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy)-phenyl]- ethylamine monohydrochloride. These results suggest that σ1 receptor agonists might function as neuroprotectant agents in Alzheimer's disease. © 2005 Lippincott Williams & Wilkins.
Prolonged exposure of cultured cortical neurons to the residue 25-35 fragment of β-amyloid protein, in the presence of dizocilpine, an antagonist of the N-methyl-D-aspartate receptor, and of 6,7-dinitroquinoxaline- 2,3-dione, an antagonist of α-amino-3-hydroxy-5-methylisoxazole-4- propionate receptors, resulted in the expression of the proapoptotic protein Bax and neuronal death. Beta-amyloid protein(25-35)-induced neuronal death was substantially attenuated by the σ1 receptor agonist 2-(4-morpholinethyl)1-phenylcyclohexanecarboxylate. The neuroprotective action of 2-(4-morpholinethyl)1-phenylcyclohexanecarboxylate was mimicked by the σ1 ligand methyl (1S,2R)-2-[1-adamantyl(methyl)amino]methyl-1- phenylcyclopropanecarboxylate and was antagonized by the σ1 receptor antagonist N,N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy)-phenyl]- ethylamine monohydrochloride. These results suggest that σ1 receptor agonists might function as neuroprotectant agents in Alzheimer's disease. © 2005 Lippincott Williams & Wilkins.
Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity
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Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity
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Calafiore M, Battaglia G, Zappal A, Trovato-Salinaro E, Caraci F, Caruso M, Vancheri C, Sortino MA, Nicoletti F, Copani A
* Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to β-amyloid (569 views)
Neurobiol Aging (ISSN: 0197-4580, 1558-1497electronic, 0197-4580linking), 2006; 27(4): 606-613.
Impact Factor: 5.599
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Filippo C, Mariangela C, Giuseppina F, Pier Luigi C, Angelo B, Marco C, Giuseppe B, Paolo B, Ferdinando N, Agata C, Maria Angela S
* Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against β-amyloid toxicity (808 views)
Brain Res (ISSN: 0006-8993), 2005; 1047(1): 30-37.
Impact Factor: 2.296
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Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F
* Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (552 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2004 Jun 30; 24(26): 6021-6027.
Impact Factor: 2.384
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15 Records (15 excluding Abstracts).
Total impact factor: 57.544 (57.544 excluding Abstracts).
Total 5 year impact factor: 58.227 (58.227 excluding Abstracts).
Total impact factor: 57.544 (57.544 excluding Abstracts).
Total 5 year impact factor: 58.227 (58.227 excluding Abstracts).
585 views. Last view on Sunday 28 May 2023, 23:48:25
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