Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (1289 views)
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
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Paper type: Journal Article, Review,
Impact factor: 3.677, 5-year impact factor: 3.047
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84859444926&partnerID=40&md5=bea942bb43325987edc933b9b4c67c5a
Keywords: β-Amyloid, Alzheimer, S Disease, Apoptosis, Cell Cycle Activation, Neuroprotection, Transforming Growth Factor-β1, 4 Amino 2 Oxabicyclo[3 1 0]hexane 4, 6 Dicarboxylic Acid, 4 Amino 2 Thiabicyclo[3 1 0]hexane 4, 2 Dioxide, Amyloid Beta Protein, Estrogen, Fluoxetine, Glatiramer, Lithium, Metabotropic Receptor Agonist, Paroxetine, Smad2 Protein, Smad3 Protein, Transforming Growth Factor Beta1, Venlafaxine, Alzheimer Disease, Amyloid Plaque, Cell Activation, Cognitive Defect, Cytokine Release, Depression, Drug Mechanism, Drug Tolerability, Gene Expression Regulation, Genetic Risk, Histopathology, Human, Immunoreactivity, Intracellular Signaling, Memory Disorder, Multiple Sclerosis, Nerve Cell Differentiation, Nerve Cell Plasticity, Nerve Degeneration, Neurofibrillary Tangle, Neuropathology, Neurotoxicity, Nonhuman, Priority Journal, Protein Aggregation, Protein Defect, Protein Function, Protein Protein Interaction, Psychosis, Review, Schizophrenia, Transforming Growth Factor Beta1 Gene, Animals, Neuroprotective Agents, Signal Transduction, Smad Proteins, Alzheimer Disease Drug Therapy Pathology Physiopathology, Neuroprotective Agents Metabolism Therapeutic Use, Signal Transduction Physiology, Smad Proteins Metabolism, Transforming Growth Factor Beta1 Metabolism, 4 Amino 2 Oxabicyclo [3 1 0] Hexane 4, 4 Amino 2 Thiabicyclo [3 1 0] Hexane 4,
Affiliations:
*** IBB - CNR ***
Department of Drug Sciences, University of Catania, Viale Andrea Doria 6, 95125 Catania, Italy
Department of Clinical and Molecular Biomedicine, Section of Pharmacology and Biochemistry, University of Catania, 95125 Catania, Italy
IRCCS Associazione Oasi Maria S.S., Institute for Research on Mental Retardation and Brain Aging, 94018 Troina, Italy
I.N.M. Neuromed, Località Camerelle, 86077 Pozzilli, Italy
Department of Human Physiology and Pharmacology, University of Rome Sapienza, 00185 Rome, Italy
I.B.B., CNR-Catania, 95125 Catania, Italy
PhD Program in Neuropharmacology, University of Catania, Catania, Italy
I. N. M. Neuromed, Localit Camerelle, 86077 Pozzilli, Italy
I. B. B., CNR-Catania, 95125 Catania, Italy
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Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
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Paper type: Journal Article, Review,
Impact factor: 3.677, 5-year impact factor: 3.047
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84859444926&partnerID=40&md5=bea942bb43325987edc933b9b4c67c5a
Keywords: β-Amyloid, Alzheimer, S Disease, Apoptosis, Cell Cycle Activation, Neuroprotection, Transforming Growth Factor-β1, 4 Amino 2 Oxabicyclo[3 1 0]hexane 4, 6 Dicarboxylic Acid, 4 Amino 2 Thiabicyclo[3 1 0]hexane 4, 2 Dioxide, Amyloid Beta Protein, Estrogen, Fluoxetine, Glatiramer, Lithium, Metabotropic Receptor Agonist, Paroxetine, Smad2 Protein, Smad3 Protein, Transforming Growth Factor Beta1, Venlafaxine, Alzheimer Disease, Amyloid Plaque, Cell Activation, Cognitive Defect, Cytokine Release, Depression, Drug Mechanism, Drug Tolerability, Gene Expression Regulation, Genetic Risk, Histopathology, Human, Immunoreactivity, Intracellular Signaling, Memory Disorder, Multiple Sclerosis, Nerve Cell Differentiation, Nerve Cell Plasticity, Nerve Degeneration, Neurofibrillary Tangle, Neuropathology, Neurotoxicity, Nonhuman, Priority Journal, Protein Aggregation, Protein Defect, Protein Function, Protein Protein Interaction, Psychosis, Review, Schizophrenia, Transforming Growth Factor Beta1 Gene, Animals, Neuroprotective Agents, Signal Transduction, Smad Proteins, Alzheimer Disease Drug Therapy Pathology Physiopathology, Neuroprotective Agents Metabolism Therapeutic Use, Signal Transduction Physiology, Smad Proteins Metabolism, Transforming Growth Factor Beta1 Metabolism, 4 Amino 2 Oxabicyclo [3 1 0] Hexane 4, 4 Amino 2 Thiabicyclo [3 1 0] Hexane 4,
Affiliations:
*** IBB - CNR ***
Department of Drug Sciences, University of Catania, Viale Andrea Doria 6, 95125 Catania, Italy
Department of Clinical and Molecular Biomedicine, Section of Pharmacology and Biochemistry, University of Catania, 95125 Catania, Italy
IRCCS Associazione Oasi Maria S.S., Institute for Research on Mental Retardation and Brain Aging, 94018 Troina, Italy
I.N.M. Neuromed, Località Camerelle, 86077 Pozzilli, Italy
Department of Human Physiology and Pharmacology, University of Rome Sapienza, 00185 Rome, Italy
I.B.B., CNR-Catania, 95125 Catania, Italy
PhD Program in Neuropharmacology, University of Catania, Catania, Italy
I. N. M. Neuromed, Localit Camerelle, 86077 Pozzilli, Italy
I. B. B., CNR-Catania, 95125 Catania, Italy
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Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection
Alzheimer's disease (AD) is a neurodegenerative disorder that affects about 35 million people worldwide. Current drugs for AD only treat the symptoms and do not interfere with the underlying pathogenic mechanisms of the disease. AD is characterized by the presence of β-amyloid (Aβ) plaques, neurofibrillary tangles, and neuronal loss. Identification of the molecular determinants underlying Aβ-induced neurodegeneration is an essential step for the development of disease-modifying drugs. Recently, an impairment of the transforming growth factor-β1 (TGF-β1) signaling pathway has been demonstrated to be specific to the AD brain and, particularly, to the early phase of the disease. TGF-β1 is a neurotrophic factor responsible for the initiation and maintenance of neuronal differentiation and synaptic plasticity. The deficiency of TGF-β1 signaling is associated with Aβ pathology and neurofibrillary tangle formation in AD animal models. Reduced TGF-β1 signaling seems to contribute both to microglial activation and to ectopic cell-cycle re-activation in neurons, two events that contribute to neurodegeneration in the AD brain. The neuroprotective features of TGF-β1 indicate the advantage of rescuing TGF-β1 signaling as a means to slow down the neurodegenerative process in AD. © Springer-Verlag 2011.
Alzheimer's disease (AD) is a neurodegenerative disorder that affects about 35 million people worldwide. Current drugs for AD only treat the symptoms and do not interfere with the underlying pathogenic mechanisms of the disease. AD is characterized by the presence of β-amyloid (Aβ) plaques, neurofibrillary tangles, and neuronal loss. Identification of the molecular determinants underlying Aβ-induced neurodegeneration is an essential step for the development of disease-modifying drugs. Recently, an impairment of the transforming growth factor-β1 (TGF-β1) signaling pathway has been demonstrated to be specific to the AD brain and, particularly, to the early phase of the disease. TGF-β1 is a neurotrophic factor responsible for the initiation and maintenance of neuronal differentiation and synaptic plasticity. The deficiency of TGF-β1 signaling is associated with Aβ pathology and neurofibrillary tangle formation in AD animal models. Reduced TGF-β1 signaling seems to contribute both to microglial activation and to ectopic cell-cycle re-activation in neurons, two events that contribute to neurodegeneration in the AD brain. The neuroprotective features of TGF-β1 indicate the advantage of rescuing TGF-β1 signaling as a means to slow down the neurodegenerative process in AD. © Springer-Verlag 2011.
Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection
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Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection
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* Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity (886 views)
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 279-304.
Impact Factor: 9.97
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Bellia F, Vecchio G, Cuzzocrea S, Calabrese V, Rizzarelli E
* Neuroprotective features of carnosine in oxidative driven diseases (490 views)
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 258-266.
Impact Factor: 9.97
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Cirillo G, Bianco MR, Colangelo AM, Cavaliere C, Daniele DL, Zaccaro L, Alberghina L, Papa M
* Reactive astrocytosis-induced perturbation of synaptic homeostasis is restored by nerve growth factor (460 views)
Neurobiology Of Disease (ISSN: 0969-9961), 2011 Mar; 41(3): 630-639.
Impact Factor: 5.403
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Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (765 views)
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
Impact Factor: 4.883
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Spina-Purrello V, Giliberto S, Barresi V, Nicoletti VG, Giuffrida Stella AM, Rizzarelli E
* Modulation of PARP-1 and PARP-2 expression by L-carnosine and trehalose after LPS and INFγ-induced oxidative stress (450 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2010 Dec; 35(12): 2144-2153.
Impact Factor: 2.608
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Giuffrida ML, Caraci F, De Bona P, Pappalardo G, Nicoletti F, Rizzarelli E, Copani A
* The monomer state of beta-amyloid: where the Alzheimer's disease protein meets physiology (681 views)
Rev Neurosci (ISSN: 0334-1763), 2010; 21(2): 83-93.
Impact Factor: 2.047
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Calabrese V, Cornelius C, Rizzarelli E, Owen JB, Dinkova-Kostova AT, Butterfield DA
* Nitric oxide in cell survival: a janus molecule (1076 views)
Antioxid Redox Signal (ISSN: 1557-7716, 1523-0864, 1523-0864linking), 2009 Nov; 11(11): 2717-2739.
Impact Factor: 7.581
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Ciaccio C, Tundo GR, Grasso G, Spoto G, Marasco D, Ruvo M, Gioia M, Rizzarelli E, Coletta M
* Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity (455 views)
J Mol Biol (ISSN: 1089-8638, 0022-2836, 1089-8638electronic), 2009 Feb 6; 385(5): 1556-1567.
Impact Factor: 3.871
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Calabrese V, Cornelius C, Mancuso C, Barone E, Calafato S, Bates T, Rizzarelli E, Kostova AT
* Vitagenes, dietary antioxidants and neuroprotection in neurodegenerative diseases (1389 views)
Frontiers In Bioscience (ISSN: 1093-4715, 1093-9946), 2009 Jan 1; 14: 376-397.
Impact Factor: 3.736
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Chiechio S, Zammataro M, Morales ME, Busceti CL, Drago F, Th Gereau RW, Copani A, Nicoletti F
* Epigenetic modulation of mGlu2 receptors by histone deacetylase inhibitors in the treatment of inflammatory pain (572 views)
Mol Pharmacol (ISSN: 0026-895x), 2009; 75(5): 1014-1020.
Impact Factor: 4.531
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Calabrese V, Cornelius C, Mancuso C, Pennisi G, Calafato S, Bellia F, Bates TE, Giuffrida Stella AM, Schapira T, Dinkova Kostova AT, Rizzarelli E
* Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity (1387 views)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2008 Dec; 33(12): 2444-2471.
Impact Factor: 2.26
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Gustavsson T, Banyasz A, Sarkar N, Markovitsi D, Improta R
* Statin: New life for an old drug (365 views)
Pharmacol Res Academic Press, 2008 Jun 23; 350(1-3): 1-2.
Impact Factor: 3.976
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Caraci F, Battaglia G, Busceti C, Biagioni F, Mastroiacovo F, Bosco P, Drago F, Nicoletti F, Sortino MA, Copani A
* TGF-β1 protects against Aβ-neurotoxicity via the phosphatidylinositol-3-kinase pathway (440 views)
Neurobiology Of Disease (ISSN: 0969-9961), 2008 May; 30(2): 234-242.
Impact Factor: 4.852
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Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA
* The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (454 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
Impact Factor: 4.823
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Calabrese V, Mancuso C, Calvani M, Rizzarelli E, Butterfield DA, Stella AM
* Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity (991 views)
Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775.
Impact Factor: 24.52
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Nicoletti VG, Santoro AM, Grasso G, Vagliasindi LI, Giuffrida ML, Cuppari C, Purrello VS, Stella AMG, Rizzarelli E
* Carnosine interaction with nitric oxide and astroglial cell protection (668 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Sep 1; 85(10): 2239-2245.
Impact Factor: 3.268
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Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
* The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (517 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
Impact Factor: 3.078
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Giuffrida ML, Grasso G, Ruvo M, Pedone C, Saporito A, Marasco D, Pignataro B, Cascio C, Copani A, Rizzarelli E
* Abeta(25-35) And Its C- And/Or N-Blocked Derivatives: Copper Driven Structural Features And Neurotoxicity (629 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Feb 15; 85(3): 623-633.
Impact Factor: 3.268
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Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
* Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (504 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2006; 26(43): 10949-10957.
Impact Factor: 2.117
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Calafiore M, Battaglia G, Zappal A, Trovato-Salinaro E, Caraci F, Caruso M, Vancheri C, Sortino MA, Nicoletti F, Copani A
* Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to β-amyloid (555 views)
Neurobiol Aging (ISSN: 0197-4580, 1558-1497electronic, 0197-4580linking), 2006; 27(4): 606-613.
Impact Factor: 5.599
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Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G
* Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (585 views)
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
Impact Factor: 1.995
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Calabrese V, Colombrita C, Guagliano E, Sapienza M, Ravagna A, Cardile V, Scapagnini G, Santoro AM, Mangiameli A, Butterfield DA, Giuffrida Stella AM, Rizzarelli E
* Protective effect of carnosine during nitrosative stress in astroglial cell cultures (441 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2005 Jun; 30(6-7): 797-807.
Impact Factor: 2.187
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Filippo C, Mariangela C, Giuseppina F, Pier Luigi C, Angelo B, Marco C, Giuseppe B, Paolo B, Ferdinando N, Agata C, Maria Angela S
* Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against β-amyloid toxicity (808 views)
Brain Res (ISSN: 0006-8993), 2005; 1047(1): 30-37.
Impact Factor: 2.296
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Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F
* Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (552 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2004 Jun 30; 24(26): 6021-6027.
Impact Factor: 2.384
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* Plant isoquinoline alkaloids as potential neurodrugs: A comparative study of the effects of benzo[c]phenanthridine and berberine based compounds on β-amyloid aggregation (145 views)
Chem Biol Interact (ISSN: 0009-2797linking), 2021 Jan 25; 334: 109300-109301.
Impact Factor: 5.192
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Pepe G, Calce E, Verdoliva V, Saviano M, Maglione V, Di Pardo A, De Luca S
* Curcumin-Loaded Nanoparticles Based on Amphiphilic Hyaluronan-Conjugate Explored as Targeting Delivery System for Neurodegenerative Disorders (60 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2020 Nov 23; 21(22): N/D-N/D.
Impact Factor: 4.556
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Spampinato SF, Copani A, Nicoletti F, Sortino MA, Caraci F
* Metabotropic Glutamate Receptors in Glial Cells: A New Potential Target for Neuroprotection? (291 views)
Front Mol Neurosci (ISSN: 1662-5099, 1662-5099linking, 1662-5099electronic), 2018 Nov 13; 11: 414-414.
Impact Factor: 3.902
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Lanza V, Milardi D, Di Natale G, Pappalardo G
* Repurposing of Copper(II)-chelating Drugs for the Treatment of Neurodegenerative Diseases (834 views)
Curr Med Chem (ISSN: 1875-533xelectronic, 0929-8673linking), 2018 Feb 12; 25(4): 525-539.
Impact Factor: 3.249
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Di Menna L, Joffe ME, Iacovelli L, Orlando R, Lindsley CW, Mairesse J, Gressèns P, Cannella M, Caraci F, Copani A, Bruno V, Battaglia G, Conn PJ, Nicoletti F
* Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system (399 views)
Neuropharm (ISSN: 0028-3908linking, 1873-7064electronic), 2018 Jan; 128: 301-313.
Impact Factor: 3.383
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Caraci F, Nicoletti F, Copani A
* Metabotropic glutamate receptors: the potential for therapeutic applications in Alzheimer's disease (544 views)
Curr Opin Pharmacol (ISSN: 1471-4892), 2017 Dec 23; 38: 1-7.
Impact Factor: 6.313
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Sciacca MFM, Romanucci V, Zarrelli A, Monaco I, Lolicato F, Spinella N, Galati C, Grasso G, D'Urso L, Romeo M, Diomede L, Salmona M, Bongiorno C, Di Fabio G, La Rosa C, Milardi D
* Inhibition of Abeta Amyloid Growth and Toxicity by Silybins: The Crucial Role of Stereochemistry (401 views) (PDF 194 views)
Acs Chem Neurosci (ISSN: 1948-7193, 1948-7193electronic), 2017 Jun 09; N/D: N/D-N/D.
Impact Factor: 4.211
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Copani A
* The underexplored question of beta-amyloid monomers (299 views)
Eur J Pharmacol (ISSN: 0014-2999), 2017 May 31; N/D: N/D-N/D.
Impact Factor: 3.04
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D'Andrea LD, Rosa LD, Vigliotti C, Cataldi M
* VEGF mimic peptides: Potential applications in central nervous system therapeutics (688 views)
New Horizons Transl Med (ISSN: 2307-5023), 2017; 3(5): 233-251.
Impact Factor: 0
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Caraci F, Tascedda F, Merlo F, Benatti C, Spampinato S, Munafò A, Leggio GM, Nicoletti F, Brunello N, Drago F, Sortino MA, Copani A
* Fluoxetine Prevents Ab1-42-Induced Toxicity via a Paracrine Signaling Mediated by Transforming-Growth- Factor-b1 (291 views) (PDF 202 views)
Frontiers In Pharmacology, 2016 Oct; 7: 1-11.
Impact Factor: 4.418
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Leggio GM, Catania MV, Puzzo D, Spatuzza M, Pellitteri R, Gulisano W, Torrisi SA, Giurdanella G, Piazza C, Impellizzeri AR, Gozzo L, Navarria A, Bucolo C, Nicoletti F, Palmeri A, Salomone S, Copani A, Caraci F, Drago F
* The antineoplastic drug flavopiridol reverses memory impairment induced by Amyloid-ss1-42 oligomers in mice (642 views)
Pharmacol Res (ISSN: 1043-6618, 1096-1186electronic), 2016 Apr; 106: 10-20.
Impact Factor: 4.48
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Palladino P, Aura AM, Spoto G
* Surface plasmon resonance for the label-free detection of Alzheimer's β-amyloid peptide aggregation (528 views)
Anal Bioanal Chem (ISSN: 1618-2642), 2016; 408(3): 849-854.
Impact Factor: 3.431
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Pignataro G, Ziaco B, Tortiglione A, Gala R, Cuomo O, Vinciguerra A, Lapi D, Mastantuono T, Anzilotti S, D'Andrea LD, Pedone C, Di Renzo G, Annunziato L, Cataldi M
* Neuroprotective Effect of VEGF-Mimetic Peptide QK in Experimental Brain Ischemia Induced in Rat by Middle Cerebral Artery Occlusion (286 views)
Acs Chem Neurosci (ISSN: 1948-7193, 1948-7193electronic), 2015 Sep 16; 6(9): 1517-1525.
Impact Factor: 4.348
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Caraci F, Pappalardo G, Basile L, Giuffrida A, Copani A, Tosto R, Sinopoli A, Giuffrida ML, Pirrone E, Drago F, Pignatello R, Guccione S
* Neuroprotective effects of the monoamine oxidase inhibitor Tranylcypromine and its amide derivatives against Abeta(1-42)-induced toxicity (805 views)
Eur J Pharmacol (ISSN: 0014-2999), 2015 Jul 7; 764: 256-263.
Impact Factor: 2.73
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Travaglia A, Pietropaolo A, Di Martino R, Nicoletti VG, La Mendola D, Calissano P, Rizzarelli E
* A Small Linear Peptide Encompassing the NGF N-Terminus Partly Mimics the Biological Activities of the Entire Neurotrophin in PC12 Cells (337 views)
Acs Chem Neurosci (ISSN: 1948-7193, 1948-7193electronic, 1948-7193linking), 2015; 6(8): 1379-1392.
Impact Factor: 4.348
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Doti N, Reuther C, Scognamiglio PL, Dolga AM, Plesnila N, Ruvo M, Culmsee C
* Inhibition of the AIF/CypA complex protects against intrinsic death pathways induced by oxidative stress (565 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2014 Jan 16; 5(1): e993-e993.
Impact Factor: 5.014
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Giuffrida ML, Tomasello F, Caraci F, Chiechio S, Nicoletti F, Copani A
* Beta-Amyloid monomer and insulin/IGF-1 signaling in Alzheimer's disease (1532 views)
Mol Neurobiol (ISSN: 0893-7648), 2012 Dec; 46(3): 605-613.
Impact Factor: 5.471
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Caraci F, Battaglia G, Sortino MA, Spampinato S, Molinaro G, Copani A, Nicoletti F, Bruno V
* Metabotropic glutamate receptors in neurodegeneration/neuroprotection: Still a hot topic? (646 views)
Neurochem Int (ISSN: 0197-0186), 2012 Sep; 61(4): 559-565.
Impact Factor: 2.659
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Calabrese V, Cornelius C, Dinkova-Kostova AT, Iavicoli I, Di Paola R, Koverech A, Cuzzocrea S, Rizzarelli E, Calabrese EJ
* Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity (4338 views)
Bba-Gen Subjects (ISSN: 0006-3002, 0925-4439, 1570-9639), 2012 May; 1822(5): 753-783.
Impact Factor: 3.733
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Calafiore M, Copani A, Deng W
* DNA polymerase-β mediates the neurogenic effect of β-amyloid protein in cultured subventricular zone neurospheres (597 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2012 Mar; 90(3): 559-567.
Impact Factor: 2.974
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Cirillo G, Colangelo AM, Bianco MR, Cavaliere C, Zaccaro L, Sarmientos P, Alberghina L, Papa M
* BB14, a Nerve Growth Factor (NGF)-like peptide shown to be effective in reducing reactive astrogliosis and restoring synaptic homeostasis in a rat model of peripheral nerve injury (402 views)
Biotechnology Advances (ISSN: 0734-9750), 2012 Jan; 30(1): 223-232.
Impact Factor: 9.599
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Calabrese V, Cornelius C, Cuzzocrea S, Iavicoli I, Rizzarelli E, Calabrese EJ
* Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity (886 views)
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 279-304.
Impact Factor: 9.97
View Export to BibTeX Export to EndNote
Bellia F, Vecchio G, Cuzzocrea S, Calabrese V, Rizzarelli E
* Neuroprotective features of carnosine in oxidative driven diseases (490 views)
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 258-266.
Impact Factor: 9.97
View Export to BibTeX Export to EndNote
Cirillo G, Bianco MR, Colangelo AM, Cavaliere C, Daniele DL, Zaccaro L, Alberghina L, Papa M
* Reactive astrocytosis-induced perturbation of synaptic homeostasis is restored by nerve growth factor (460 views)
Neurobiology Of Disease (ISSN: 0969-9961), 2011 Mar; 41(3): 630-639.
Impact Factor: 5.403
View Export to BibTeX Export to EndNote
Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (765 views)
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
Impact Factor: 4.883
View Export to BibTeX Export to EndNote
Spina-Purrello V, Giliberto S, Barresi V, Nicoletti VG, Giuffrida Stella AM, Rizzarelli E
* Modulation of PARP-1 and PARP-2 expression by L-carnosine and trehalose after LPS and INFγ-induced oxidative stress (450 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2010 Dec; 35(12): 2144-2153.
Impact Factor: 2.608
View Export to BibTeX Export to EndNote
Giuffrida ML, Caraci F, De Bona P, Pappalardo G, Nicoletti F, Rizzarelli E, Copani A
* The monomer state of beta-amyloid: where the Alzheimer's disease protein meets physiology (681 views)
Rev Neurosci (ISSN: 0334-1763), 2010; 21(2): 83-93.
Impact Factor: 2.047
View Export to BibTeX Export to EndNote
Calabrese V, Cornelius C, Rizzarelli E, Owen JB, Dinkova-Kostova AT, Butterfield DA
* Nitric oxide in cell survival: a janus molecule (1076 views)
Antioxid Redox Signal (ISSN: 1557-7716, 1523-0864, 1523-0864linking), 2009 Nov; 11(11): 2717-2739.
Impact Factor: 7.581
View Export to BibTeX Export to EndNote
Ciaccio C, Tundo GR, Grasso G, Spoto G, Marasco D, Ruvo M, Gioia M, Rizzarelli E, Coletta M
* Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity (455 views)
J Mol Biol (ISSN: 1089-8638, 0022-2836, 1089-8638electronic), 2009 Feb 6; 385(5): 1556-1567.
Impact Factor: 3.871
View Export to BibTeX Export to EndNote
Calabrese V, Cornelius C, Mancuso C, Barone E, Calafato S, Bates T, Rizzarelli E, Kostova AT
* Vitagenes, dietary antioxidants and neuroprotection in neurodegenerative diseases (1389 views)
Frontiers In Bioscience (ISSN: 1093-4715, 1093-9946), 2009 Jan 1; 14: 376-397.
Impact Factor: 3.736
View Export to BibTeX Export to EndNote
Chiechio S, Zammataro M, Morales ME, Busceti CL, Drago F, Th Gereau RW, Copani A, Nicoletti F
* Epigenetic modulation of mGlu2 receptors by histone deacetylase inhibitors in the treatment of inflammatory pain (572 views)
Mol Pharmacol (ISSN: 0026-895x), 2009; 75(5): 1014-1020.
Impact Factor: 4.531
View Export to BibTeX Export to EndNote
Calabrese V, Cornelius C, Mancuso C, Pennisi G, Calafato S, Bellia F, Bates TE, Giuffrida Stella AM, Schapira T, Dinkova Kostova AT, Rizzarelli E
* Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity (1387 views)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2008 Dec; 33(12): 2444-2471.
Impact Factor: 2.26
View Export to BibTeX Export to EndNote
Gustavsson T, Banyasz A, Sarkar N, Markovitsi D, Improta R
* Statin: New life for an old drug (365 views)
Pharmacol Res Academic Press, 2008 Jun 23; 350(1-3): 1-2.
Impact Factor: 3.976
View Export to BibTeX Export to EndNote
Caraci F, Battaglia G, Busceti C, Biagioni F, Mastroiacovo F, Bosco P, Drago F, Nicoletti F, Sortino MA, Copani A
* TGF-β1 protects against Aβ-neurotoxicity via the phosphatidylinositol-3-kinase pathway (440 views)
Neurobiology Of Disease (ISSN: 0969-9961), 2008 May; 30(2): 234-242.
Impact Factor: 4.852
View Export to BibTeX Export to EndNote
Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA
* The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (454 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
Impact Factor: 4.823
View Export to BibTeX Export to EndNote
Calabrese V, Mancuso C, Calvani M, Rizzarelli E, Butterfield DA, Stella AM
* Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity (991 views)
Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775.
Impact Factor: 24.52
View Export to BibTeX Export to EndNote
Nicoletti VG, Santoro AM, Grasso G, Vagliasindi LI, Giuffrida ML, Cuppari C, Purrello VS, Stella AMG, Rizzarelli E
* Carnosine interaction with nitric oxide and astroglial cell protection (668 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Sep 1; 85(10): 2239-2245.
Impact Factor: 3.268
View Export to BibTeX Export to EndNote
Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
* The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (517 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
Impact Factor: 3.078
View Export to BibTeX Export to EndNote
Giuffrida ML, Grasso G, Ruvo M, Pedone C, Saporito A, Marasco D, Pignataro B, Cascio C, Copani A, Rizzarelli E
* Abeta(25-35) And Its C- And/Or N-Blocked Derivatives: Copper Driven Structural Features And Neurotoxicity (629 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Feb 15; 85(3): 623-633.
Impact Factor: 3.268
View Export to BibTeX Export to EndNote
Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
* Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (504 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2006; 26(43): 10949-10957.
Impact Factor: 2.117
View Export to BibTeX Export to EndNote
Calafiore M, Battaglia G, Zappal A, Trovato-Salinaro E, Caraci F, Caruso M, Vancheri C, Sortino MA, Nicoletti F, Copani A
* Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to β-amyloid (555 views)
Neurobiol Aging (ISSN: 0197-4580, 1558-1497electronic, 0197-4580linking), 2006; 27(4): 606-613.
Impact Factor: 5.599
View Export to BibTeX Export to EndNote
Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G
* Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (585 views)
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
Impact Factor: 1.995
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Calabrese V, Colombrita C, Guagliano E, Sapienza M, Ravagna A, Cardile V, Scapagnini G, Santoro AM, Mangiameli A, Butterfield DA, Giuffrida Stella AM, Rizzarelli E
* Protective effect of carnosine during nitrosative stress in astroglial cell cultures (441 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2005 Jun; 30(6-7): 797-807.
Impact Factor: 2.187
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Filippo C, Mariangela C, Giuseppina F, Pier Luigi C, Angelo B, Marco C, Giuseppe B, Paolo B, Ferdinando N, Agata C, Maria Angela S
* Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against β-amyloid toxicity (808 views)
Brain Res (ISSN: 0006-8993), 2005; 1047(1): 30-37.
Impact Factor: 2.296
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Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F
* Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (552 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2004 Jun 30; 24(26): 6021-6027.
Impact Factor: 2.384
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45 Records (44 excluding Abstracts).
Total impact factor: 208.274 (203.26 excluding Abstracts).
Total 5 year impact factor: 204.658 (199.367 excluding Abstracts).
Total impact factor: 208.274 (203.26 excluding Abstracts).
Total 5 year impact factor: 204.658 (199.367 excluding Abstracts).
1289 views. Last view on Sunday 14 May 2023, 21:13:26
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